PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,676,372 | electrolyt chang contemporari hemodialysi secondari analysi monitor dialysi mid studi pauciti contemporari data examin electrolyt chang immedi hemodialysi hd relationship dialys prescript present studi examin relationship | D015314;D006435 | T121;T061 |
34,676,267 | salivari serum interleukin c reactiv protein mean platelet volum crpmpv ratio diagnosi late onset neonat sepsi full term neonat salivari marker could serv potenti noninvas marker diagnosi neonat infect aim investig diagnost role salivari serum interleukin il c reactiv protein crp mean platelet volum mpv crpmpv ratio diagnosi late onset neonat sepsi full term neonat seventi full term neonat enrol prospect case control studi late onset neonat sepsi control salivari il serum il crp concentr measur enzym link immunosorb assay elisa complet blood cbc count measur autom blood cell counter salivari il serum il crp mpv crpmpv ratio level much higher neonat late onset sepsi control vs pgml p vs pgml p vs mgl p vs fl vs p salivari serum il show posit correl crp crpmpv ratio septic neonat current studi show first time salivari il crpmpv show statist signific differ neonat late onset sepsi control accord salivari il could serv potenti noninvas biomark diagnosi late onset sepsi full term neonat | D063847 | T059 |
34,676,263 | extend epidemiolog model weak econom region case studi spread covid south asian subcontinent countri ascend coronavirus becom widespread around world prevent viral transmiss pattern diseas explor epidemiolog model vital compon research model assist studi various aspect infecti diseas death recoveri infect rate coronavirus trend across sever countri may analyz suffici use sir seir siqr model across studi propos two modifi version seird method evalu transmiss infecti diseas south asian countri precis south asian subcontin seird model updat fuse new factor name isol suspect peopl recoveri death peopl coverag healthcar scheme reluct receiv treatment various catastroph investig influenc ingredi public health relat issu final predict display infect scenario relev element conclud remark statist analysi | D008962 | T062;T170 |
34,676,261 | master slave binari grey wolf optim optim featur select biomed data classif new master slave binari grey wolf optim msbgwo introduc master slave learn scheme introduc grey wolf optim gwo improv abil explor get better solut search space five high dimension biomed dataset use test abil msbgwo featur select experiment result msbgwo superior term classif accuraci precis recal f measur number featur select compar binari grey wolf optim version bgwo binari genet algorithm bga binari particl swarm optim bpso differenti evolut de algorithm sine cosin algorithm sca | D000465;D000069550 | T170;T066 |
34,676,259 | covid diagnosi use capsul network fuzzi c mean mayfli optim algorithm covid epidem spread day day earli diagnosi diseas essenti provid effect prevent therapeut measur process use comput aid methodolog improv accuraci studi new optim method util diagnosi covid method base fuzzi c order mean fcom along improv version enhanc capsul network ecn propos purpos propos ecn method improv base mayfli optim mfo algorithm suggest techniqu implement chest x ray covid imag public avail dataset simul result assess consid comparison state art method includ fompa mid dt result show propos method accuraci precis provid highest accuraci reliabl compar studi method moreov result show propos method sensit rate highest ratio final propos method f score rate give uppermost valu compar other | D000465 | T170 |
34,676,196 | review emerg medic servic vulner high consequ infecti diseas unit state purpos emerg medic servic em respond group medic skill profession perform wide rang essenti medic servic within communiti includ emerg respons patient transport mobil integr healthcar proper function em system paramount well medic system public health intent paper review current em standard practic determin danger high consequ infecti diseas hcid may pose healthcar worker communiti area address review em practic sever area identifi vulner em network vulner consist lack standard licens practic inconsist medic direct inabl proper implement use person protect equip ppe compound vulner allow hcid pose serious threat em personnel possibl devast crippl em infrastructur within us discuss vulner identifi must address protect em provid enhanc resili us healthcar system way address identifi vulner focus improv em curriculum increas minimum level educ first respond target minimum educ train standard could effect method reduc danger hcid em system | D003141;D004632 | T058;T047;T093;T061 |
34,676,194 | emerg emerg vector born infecti diseas challeng control review vector born emerg emerg diseas pose consider public health problem worldwid diseas emerg andor emerg increas rate appear new region past two decad studi emphas interact among pathogen host environ play key role emerg emerg diseas furthermor social demograph factor human popul growth urban global trade exchang travel close interact livestock signific link emerg andor emerg vector born diseas studi emphas ongo evolut pathogen prolifer reservoir popul antimicrobi drug use princip exacerb forc emerg emerg vector born infecti diseas still studi equivoc claim climat chang associ appear resurg vector born infecti diseas despit fact mani import emerg emerg vector born infecti diseas becom better control success stop mani new appear resurg vector born infecti diseas may happen futur seem uncertain henc paper review synthes exist literatur explor global pattern emerg emerg vector born infect challeng control also attempt give insight epidemiolog profil major vector born diseas includ zika fever dengu west nile fever crimean congo hemorrhag fever chikungunya yellow fever rift valley fever | D065632;D021821;D000079426;D015004;D000071244;D000071243 | T047;T005 |
34,676,193 | expect demand elder care servic anticip live arrang among oldest old china base andersen model object first aim studi explor expect demand oldest old determin differ type elder care servic second aim investig prefer choic live arrang among oldest old influenc factor method data particip age year extract chines longitudin health longev survey carri use andersen model analysi framework multipl logist regress analysi perform analyz relationship expect elder care servic live arrang influenc factor odd ratio calcul indic relationship influenc factor depend variabl result descript analysi result found oldest old show high anticip need home visit health educ exist huge imbal suppli demand care servic age live children still import way provid oldest old regress result show expect demand elder care servic anticip live arrang among oldest old china influenc age resid hous properti right econom status loneli activ daili live adl oldest old older without hous properti right childless restrict adl frequent observ live long term care institut conclus inequ suppli expect demand elder care servic live children still prefer choic chines oldest old find indic plan promot elder care servic among oldest old import consid expect especi subgroup relat disadvantag relat polici develop offer incent famili caregiv live oldest old | D000203;D012111 | T082;T056;T083;T033;T081;T078;T080;T096 |
34,676,192 | multiethn asian perspect presum consent organ donat popul base percept studi background organ shortag still world wide problem result long wait list kidney liver heart transplant candid across mani transplant center global result move toward presum consent increas deceas organ donat rate howev remain pauciti literatur public attitud barrier regard opt system exist studi limit western nation therefor studi aim understand public sentiment differ barrier toward organ donat perspect singapor high divers multiethn asian societi method cross section communiti semi structur interview conduct public hous estat singapor pilot test undertaken particip interview face face train personnel statist evalu conduct use stata test compar subgroup base patient characterist multivari logist regress identifi predictor willing donat assent effect estim quantifi use odd ratio find individu agreeabl organ donat death will assent donat famili member organ declin p clinic scenario present demograph factor includ ethnic educ marit employ status affect willing donat assent knowledg correl signific willing donat assent particular knowledg regard brain death irrevers strongest correl aor ci conclus organ donat rate remain low albeit presum consent legisl due patient level barrier includ limit knowledg gap cultur valu religi background emot impact relat death effect boost donor rate crucial polici maker invest public educ improv transplant provis famili protocol | D019724;D009927 | T089;T073;T055;T058;T033 |
34,676,191 | effect daili case room disinfect endoscopi unit background evalu effect daili case room disinfect endoscopi unit method studi conduct endoscopi unit first affili zhejiang chines medic univers cultur sampl surfac endoscopi unit item includ oper unit air isol gown endoscopist control panel button workstat mous bed head patient sampl divid daili case room disinfect group addit group subdivid sedat nonsed gastroscopi without ventil room group result qualifi rate bed head sampl patient lower daili room disinfect group compar case group isol gown mous workstat bed head patient demonstr lowest bacteri fungal load case room disinfect group compar daili room disinfect group p subgroup analysi higher microbi load observ isol gown endoscopist use nonsed gastroscopi unventil room case room disinfect pattern p higher microbi load observ control panel button use nonsed gastroscopi case room disinfect pattern p conclus risk free low risk patient daili room disinfect provid basic health requir endoscopi procedur howev better adopt case room disinfect isol gown endoscopist bed head patient patient high risk case room disinfect suitabl everi endoscopi unit wwwclinicaltrialsgov nct | D004203;D005658 | T004;T061 |
34,676,176 | long term effect nine amino acid antimicrobi peptid hepc pseudomona aeruginosa detect resist emerg multidrug resist mdr pathogen becom global public health crisi among mdr pseudomona aeruginosa main caus nosocomi infect death antimicrobi peptid amp consid competit drug candid address threat studi character two amp hepc hepc potent activ new clinic isol mdr p aeruginosa amp destroy integr cell membran induc leakag intracellular compon ultim led cell death long term compar studi bacteri resist treat hepc hepc common use antibiot show p aeruginosa quick develop resist nine antibiot test includ aztreonam ceftazidim cefepim imipenem meropenem ciprofloxacin levofloxacin gentamicin piperacillin earli day day success cultur generat initi effect concentr antibiot p aeruginosa great increas differ high level day howev hepc hepc maintain initi mic unchang day indic p aeruginosa produc signific resist amp furthermor hepc show toxic effect mammalian cell vitro mice vivo hepc therapeut effect mdr p aeruginosa infect use mous lung infect model could effect increas surviv rate mice inhibit bacteri prolifer attenu lung inflamm taken togeth short peptid hepc would promis agent clinic treatment mdr p aeruginosa infect | D011552;D011550 | T007;T047 |
34,676,175 | molecular character dengu virus type zhejiang dengu fever df mosquito born viral diseas caus dengu virus denv consid one import arbovirus world studi aim determin molecular epidemiolog phylogenet character denv indigen case import case isol nine municip zhejiang provinc analys phylogenet haplotyp amino acid substitut conduct base full envelop e gene sequenc sixti four haplotyp cluster two main clade isol wenzhou taizhou main cluster clade hangzhou ningbo case cluster clade ii six site amino acid substitut includ fl mv ts il vi observ strain isol ningbo hangzhou two site amino acid substitut includ vl vi observ strain taizhou wenzhou studi strain high homolog strain southeast asian countri thus case zhejiang probabl import southeast asian countri strain differ region zhejiang cluster branch may caus continu import case countri differ time period continu outbreak zhejiang provinc site dengu gene mutat effect need studi | D003715;D003716 | T047;T005 |
34,676,150 | apoptosi induc transloc centromer protein f correspond autoantibodi product hepatocellular carcinoma serum autoantibodi tumor associ antigen import valu earli diagnosi hepatocellular carcinoma hcc mechan autoantibodi product poor understood previous show autoantibodi centromer protein f cenpf may use earli diagnost marker hcc explor mechan cell apoptosi base cenpf autoantibodi product verifi correl cenpf autoantibodi level hcc develop demonstr cenpf overexpress aberr local throughout nuclei cytoplasm human hcc cell compar hepat cell cenpf overexpress promot product cenpf autoantibodi manner correl tumor growth mous hcc model apoptosi hcc cell cenpf protein transloc apoptot vesicl reloc cell surfac isol apoptot compon found apoptot bodi bleb lower cd cd express effect induc dc phagocytosi matur compar apoptot intact cell vitro dc respons independ cenpf express moreov inject mice apoptot bodi bleb effect induc immun respons product cenpf specif antibodi find provid first elucid mechan under cenpf autoantibodi product via cell apoptosi induc cenpf transloc demonstr direct correl cenpf autoantibodi level hcc progress suggest potenti cenpf autoantibodi hcc diagnost marker | D006528;D002868;D008113;D008840 | T191;T116;T123 |
34,676,149 | identif pyroptosi relat subtyp develop prognosi model character tumor microenviron infiltr colorect cancer pyroptosi newli discov program cell death associ tumor progress prognosi treatment respons howev potenti role pyroptosi relat gene prgs tumor microenviron tme remain unclear describ alter prgs colorect cancer crc sampl genet transcript field evalu express pattern four independ dataset identifi two distinct molecular subtyp found multi layer prg alter correl patient clinicopatholog featur prognosi tme cell infiltr characterist prgscore predict recurr free surviv rfs construct predict capabl crc patient valid consequ construct high accur nomogram improv clinic applic prgscore low prgscore character increas microsatellit instabl high msi h mutat burden immun activ indic favor odd rfs moreov prgscore signific associ cancer stem cell csc index chemotherapeut drug sensit comprehens analysi prgs crc demonstr potenti role tumor immun stromal microenviron clinicopatholog featur prognosi find may improv understand prgs crc pave new path assess prognosi develop effect immunotherapi strategi | D015179;D059016 | T070;T191 |
34,676,148 | cd lymphocyt sensit nkgahla e licens interact role surviv cancer patient nk cd cell main cytolyt effector involv innat adapt tumor immun surveil respect although educ pathway differ similar develop function suggest cd lymphocyt could sensit nk cell licens signal might influenc antitumor respons demonstr hypothesi retrospect evalu impact nk cell licens interact express cd cd lymphocyt surviv patient differ hematopoiet solid cancer n prospect analyz multiparametr flow cytometri anti cdcd induc prolifer immun receptor express purifi cd lymphocyt healthi donor n differ combin nk cell licens ligand result show methioninethreonin mt dimorph posit hla b leader peptid hla class dimorph involv educ nk cell hla cc hla bw associ greater surviv express cd cancer patient proport number methionin present genotyp cd lymphocyt healthi donor show higher prolifer rate lower express tigit vitro stimul therefor cd lymphocyt like nk cell appear sensit mt dimorph hla b leader peptid result modul cd vivo prolifer express tigit vitro stimul could relat immun surveil capac surviv cancer patient | D018414;D009369 | T025;T191 |
34,676,147 | trial watch intratumor immunotherapi chemotherapi radiotherapi remain first line approach manag unresect tumor immunotherapi emerg past two decad game chang treatment notabl clinic success immun checkpoint inhibitor immunotherapi aim activ anticanc immun respons occur two main step activ expans tumor specif cell follow cross present tumor antigen special myeloid cell prime phase immunolog clearanc malign cell antitumor lymphocyt effector phase therapeut vaccin adjuv monoclon antibodi cytokin immunogen cell death induc agent includ oncolyt virus anthracyclin base chemotherapi radiotherapi well adopt cell transfer act differ level cascad instat cancer immunosurveil intratumor deliveri immunotherapeut test clinic trial promot superior antitumor immun activ context limit system toxic | D009369;D050504 | T191;T005 |
34,676,103 | measur protein biomark concentr use antibodi tag magnet nanoparticl physiolog condit biomark concentr tend rise fall time eg inflamm ex vivo measur provid snapshot time biomark concentr use limit approach real time monitor biomark concentr use wearabl implant inject vivo sensor therefor appeal target earli step toward develop vivo biomark sensor antibodi ab tag magnet nanoparticl nps use demonstr vitro measur distinct biomark high specif sensit previous work aptam use target given biomark vitro generat magnet cluster exhibit characterist rotat signatur quit differ free nps method expand detect much wider rang biomark use polyclon ab attach surfac nps commerci ab exist wide rang target allow accur specif concentr measur signific biomark show suffici detect sensit use hous spectromet measur rotat signatur nps assess physiolog concentr hormon cytokin signal molecul detect limit biomark drawn main pain inflamm target pm mous granzym b mgzm b pm mous interferon gamma mifn pm mous interleukin mil pm rat interleukin ril pm mous vascular endotheli growth factor mvegf pm rat calcitonin gene relat peptid rcgrp much lower detect limit certain possibl use improv spectromet nanoparticl | D000906;D015374;D058185 | T116;T121;T130;T129;T075;T059 |
34,676,063 | studi effect combin prednison vitamin treatment primari nephrot syndrom children studi effect prednison combin vitamin treatment primari nephrot syndrom children | D009404 | T047 |
34,676,062 | solubl dietari fiber signific obes western china popul studi aim investig whether solubl dietari fiber sdfs could protect obes influenc weight bodi mass index bmi bodi fat rate bfr viscer fat rate vfr waistlin | D004032;D009765 | T047;T168 |
34,676,061 | interpret detect locat myocardi infarct base ventricular fusion rule featur myocardi infarct mi one common cardiovascular diseas threaten human life order accur distinguish myocardi infarct good interpret classif method combin rule featur ventricular activ featur propos paper specif accord clinic diagnosi rule patholog chang myocardi infarct electrocardiogram local inform extract q wave st segment wave comput rule featur sampl qt segment extract ventricular activ featur order reduc comput complex ventricular activ featur effect discret wavelet transform dwt princip compon analysi pca local preserv project lpp extract ventricular activ featur compar combin rule featur ventricular activ featur lead featur fuse ultim featur vector final extrem gradient boost xgboost use identifi myocardi infarct overal accuraci rate obtain physikalisch technisch bundesanstalt ptb databas method good medic diagnosi basi improv accuraci import clinic decis make | D000465;D009203 | T047;T170 |
34,675,992 | bayesian analysi cancer data use compon exponenti mixtur model cancer among major public health problem well burden pakistan new patient diagnos cancer year almost patient die due fatal diseas lung breast liver cervic bloodbon marrow oral cancer common cancer pakistan perhap smoke physic inact infect exposur toxin unhealthi diet main factor respons spread cancer prefer novel four compon mixtur model bayesian estim estim averag number incid death gender differ age group purpos consid differ kind cancer diagnos recent year data regist patient pakistan year taken globocan patient divid age group also split base gender appli propos mixtur model bayesian analysi perform data use four compon exponenti mixtur model estim mixtur model paramet deriv bayesian procedur use three differ prior two loss function simul studi graphic represent estim also present note analysi real data bay estim linex loss assum jeffrey prior effici incid male femal far death concern linex loss assum jeffrey prior give better result male popul femal popul best loss function self assum jeffrey prior | D001499 | T081 |
34,675,972 | cost sensit siames network pcb defect classif product print circuit board pcb pcb manufactur need remov defect board conduct rigor test manual inspect time consum labori mani pcb factori employ automat optic inspect aoi pixel base comparison method high fals alarm rate thus requir intens human inspect determin whether alarm rais resembl true pseudo defect paper propos new cost sensit deep learn model cost sensit siames network css net base siames network transfer learn threshold move method distinguish true pseudo pcb defect cost sensit classif problem use optim algorithm nsga ii determin optim cost sensit threshold result show model improv true defect predict accuraci maintain relat high pseudo defect predict accuraci real product scenario furthermor model also outperform state art competitor model comprehens cost sensit metric averag shorter train time | D000465;D019985 | T170;T081 |
34,675,971 | earli predict sepsi base machin learn algorithm sepsi organ failur diseas caus infect result extrem high mortal machin learn algorithm xgboost lightgbm appli construct two process method mean process method featur generat method aim predict earli sepsi hour advanc featur generat method construct combin differ featur includ statist strength featur window featur medic featur miceforest multipl interpol method appli tackl larg miss data problem result show featur generat method outperform mean process method xgboost lightgbm algorithm excel predict perform auc among lightgbm boast faster run speed stronger general abil especi multidimension data auc reach featur generat method ptt wbc platelet key risk factor predict earli sepsi | D000069550;D018805 | T047;T066;T046 |
34,675,970 | robust track control euler lagrang system base barrier lyapunov function self structur neural network articl studi robust track control problem euler lagrang el system uncertainti enhanc robust control system asymmetr tan type barrier lyapunov function atblf use dynam constraint posit track error deal problem system uncertainti self structur neural network ssnn develop estim unknown dynam model avoid calcul burden robust compens design estim compens neural network nn approxim error unknown disturb addit relat threshold event trigger strategi introduc great save communic resourc propos robust control scheme track behavior implement disturb unknown dynam el system signal close loop system prove bound stabil analysi track error converg neighborhood near origin numer simul result show effect valid propos robust control scheme | D000465;D017711 | T170;T077 |
34,675,942 | immunotherapi hepatocellular carcinoma current status futur prospect hepatocellular carcinoma hcc preval primari liver cancer poor prognosi surgeri chemotherapi radiofrequ ablat three convent therapeut option help limit percentag hcc patient cancer immunotherapi achiev dramat advanc recent year provid new opportun treat hcc howev hcc various etiolog evad immun system multipl mechan rapid develop genet engin synthet biolog varieti novel immunotherapi employ treat advanc hcc includ immun checkpoint inhibitor adopt cell therapi engin cytokin therapeut cancer vaccin review summar current landscap research progress differ immunotherapi strategi treatment hcc challeng opportun research field also discuss | D007167 | T061 |
34,675,936 | multi omic data analys identifi b h novel prognost biomark predict respons immun checkpoint blockad head neck squamous cell carcinoma b homolog b h recent found superfamili b molecul therefor signific involv immunolog regul howev relationship b h express tumor microenviron tme respons immunotherapi prognosi head neck squamous cell carcinoma hnscc still unknown present analysi determin b h novel biomark predict prognosi respons immunotherapi hnscc b h express enhanc hnscc compar normal sampl stabli express hnscc cell line besid high b h express correl dismal prognosi resist immunotherapi contribut immunosuppress microenviron moreov singl cell rna sequenc scrna seq analysi show b h main express stromal well malign cell conclus studi provid insight understand prognost valu b h hnscc highlight involv promot immunosuppress microenviron present attract strategi antibodi base immunotherapi | D007167 | T061 |
34,675,934 | identif novel serolog marker seroneg rheumatoid arthriti use peptid librari approach rheumatoid arthriti ra system autoimmun diseas character chronic inflamm main affect joint lead cartilag bone destruct definit seroposit seroneg ra base presenc absenc rheumatoid factor rf anti citrullin peptid antibodi acpa autoantibodi identifi last decad antibodi direct carbamyl antigen peptidyl arginin deiminas type v raf murin sarcoma viral oncogen homologu b order identifi relev autoantigen screen random peptid librari rpl pool igg obtain patient seroneg ra patient sera use elisa test identifi frequent recogn peptid among obtain screen rpl sera age sex match healthi subject use control identifi specif peptid ra peptid recogn ra patient sera healthi subject patient immun mediat diseas major sera seroneg seroposit ra patient respect contain igg antibodi direct ra peptid interest peptid share homolog self antigen protein tyrosin kinas beta b cell scaffold protein liprin alfa cytotox lymphocyt protein affin purifi anti ra peptid antibodi abl cross react autoantigen conclus identifi peptid recogn seroposit import seroneg ra patient sera healthi subject confer epitop high degre specif peptid share also homolog autoantigen recogn autoantibodi present seroneg ra sera newli identifi autoantibodi although present also percentag seroposit ra patient may consid novel serum biomark seroneg ra lack presenc rf andor acpa | D019151 | T130;T116 |
34,675,932 | nk cell reconstitut autolog hematopoiet stem cell transplant associ nk cell matur stage outcom multipl myeloma autolog hematopoiet stem cell transplant autohsct standard care transplant elig patient multipl myeloma mm among factor influenc outcom autohsct suggest number natur killer nk cell play import role howev impact differ nk cell subset phenotyp could diseas progress autohsct less clear reason phenotyp function character nk cell immun system reconstitut autohsct mm patient short leukocyt recoveri extens redistribut nk cell subset occur patient addit nk cell undergo profound phenotyp chang character among other increas prolif capac immatur phenotyp import mm patient show lower frequenc matur high differenti nkga cd nk cell subset day autohsct experienc superior progress free surviv longer time next treatment higher frequenc result provid signific insight nk cell reconstitut autohsct suggest degre nk cell matur autohsct affect clinic outcom mm patient treat therapeut strategi | D018380 | T061 |
34,675,930 | blood transcriptom anti sar cov antibodi posit healthi individu experienc asymptomat versus clinic infect reason behind clinic variabl sar cov infect rang asymptomat infect lethal diseas still unclear perform genom wide transcript whole blood rna sequenc bioinformat analysi pcr valid test hypothesi immun respons relat gene signatur reflect baselin may differ healthi individu equal robust antibodi respons experienc entir asymptomat n versus clinic sar cov infect n past month mean week among protein code gene analys identifi six nine gene signific decreas increas express respect prior asymptomat infect relat clinic infect six gene decreas express ifit ifil rsad folr pi alox involv innat immun respons first two interferon induc protein among gene increas express six involv immun respons gzmh clecb cleca viral mrna translat gcat energi metabol cacnad oxid stress respons enc notabl differenti express gene regul interferon result suggest subtl differ baselin express innat immun relat gene may associ asymptomat diseas cours sar cov infect whether certain gene signatur predict develop effici immun respons upon exposur sar cov implic priorit vaccin warrant studi | D058345 | T047 |
34,675,926 | unsatisfi report qualiti clinic trial evalu immun checkpoint inhibitor therapi cancer immun oncolog trial conduct treat various cancer yet unclear report qualiti immun oncolog trial characterist associ higher report qualiti | D002986;D007167;D012107 | T096;T170;T169;T061;T081;T062 |
34,675,922 | strong associ myriad discret speckl nuclear pattern anti ss aro antibodi consensus experi four intern expert center morpholog pattern indirect immunofluoresc assay hep cell hep ifa reflect autoantibodi sampl intern consensus ana pattern icap classifi relev pattern ac ac ac fine speckl nuclear pattern associ anti ss aro anti ss bla sever autoantibodi anti ss aro sampl may contain antibodi ro ro variat ac herein design ac character myriad discret nuclear speckl report associ anti ss aro plain fine speckl pattern herein design ac b seldom associ anti ss aro studi report experi four expert laboratori ac ac b | D019084 | T059 |
34,675,917 | gm csf nitrat new driver myeloid suppressor cell activ tumor reactiv oxygen speci includ rns contribut control multipl immun cell function within tumor microenviron tme tumor infiltr myeloid cell tim repres archetyp tolerogen cell activ contribut dismantl effect immun cancer tim inhibit cell function promot tumor progress sever mechan includ amplif oxidativenitros stress within tme tumor tim expans differenti regul granulocyt macrophag coloni stimul factor gm csf produc cancer immun cell nevertheless role gm csf tumor yet fulli elucid studi show gm csf activ signific affect rns trigger post translat modif nitrat singl tryptophan residu sequenc gm csf nourish expans high immunosuppress myeloid subset tumor bear host import tumor colorect cancer patient express higher level nitrat tryptophan compar non neoplast tissu collect data identifi novel select target exploit remodel tme foster protect immun cancer | D011499 | T044 |
34,675,916 | neutrophil dynam affect mycobacterium tuberculosi granuloma outcom dissemin neutrophil infiltr tubercul granuloma often associ higher bacteria load sever diseas basi relationship well understood better elucid connect neutrophil patholog primat system pair data experiment studi next generat comput model gransim identifi neutrophil relat factor includ neutrophil recruit lifespan intracellular bacteria number drive granuloma level outcom predict mechan under spatial organ neutrophil within granuloma identifi neutrophil contribut granuloma dissemin also perform virtual delet deplet neutrophil within granuloma found neutrophil play nuanc role determin granuloma outcom promot uncontrol bacteri growth work contain bacteri growth other present three key result show neutrophil facilit local dissemin granuloma therebi enabl spread infect suggest neutrophil influenc cfu burden innat adapt immun respons impli may target therapeut intervent later stage infect use uncertainti sensit analys predict neutrophil process drive granuloma sever structur | D003198;D018448;D020556 | T039;T170;T066 |
34,675,915 | multiplex microspher base flow cytometr assay assess strain transcend antibodi plasmodium vivax duffi bind protein ii reveal effici tool identifi bind inhibitori antibodi respond malaria remain major public health problem worldwid plasmodium vivax wide distribut malaria parasit natur acquir bind inhibitori antibodi biab region ii duffi bind protein dbpii p vivax ligand critic reticulocyt invas associ reduc risk clinic malaria owe methodolog issu evalu antibodi inhibit dbpii darc interact limit number studi investig dbpii biab p vivax expos popul base assumpt individu consist biab respons character strain transcend immun respons hypothes detect broad reactiv dbpii antibodi would indic presenc biab respons take advantag engin dbpii immunogen target conserv dbpii neutral epitop deknul standard multiplex flow cytometri base serolog assay detect broad neutral igg antibodi studi standard vitro cytoadher assay cos cell express dbpii use test dbpii biab respons long term p vivax expos amazonian individu taken togeth result demonstr dbpii base multiplex assay facilit identifi dbpii biab carrier relev abil multiplex assay identifi biab respond high accur posit antigen consid conclus standard dbpii base flow cytometr assay confirm dbpii biab activ associ breadth rather magnitud anti dbpii antibodi altogeth result suggest multiplex detect broad dbpii reactiv antibodi facilit preliminari screen biab respond | D000913;D005434 | T129;T059 |
34,675,882 | new clinic model estim pre test probabl cush syndrom cush score hypercortisol account relev morbid mortal often diagnost challeng clinician prompt diagnosi necessari treat cush syndrom earli possibl | D015233 | T170;T081 |
34,675,881 | bariatr surgeri induc differenti effect plasma aldosteron comparison dietari advic alon pathophysiolog mechan link weight loss blood pressur bp reduct complet understood object studi compar effect weight loss roux en gastric bypass rygb bp renin angiotensin aldosteron system raa urinari electrolyt excret dietari advic | D050110 | T061 |
34,675,880 | role genet earli life environment factor associ overweight obes hypertens popul base twin studi aim explor whether extent overweight obes could increas risk hypertens estim role genet earli life famili environment factor associ | D004777 | T082;T067 |
34,675,879 | associ anthropometr indic develop diabet among hypertens patient china cohort studi patient comorbid hypertens diabet associ higher morbid mortal cardiovascular diseas hypertens diabet alon present studi aim identifi anthropometr risk factor diabet among hypertens patient includ retrospect cohort studi | D015992;D065927 | T033;T201 |
34,675,782 | circuit investig social interact substanc use disord use miniscop substanc use disord sud comorbid devast health issu social withdraw isol success clinic treatment sud use social intervent neuron encod drug cue drug cue trigger relaps import studi activ circuit embed cell type encod drug cue develop sud explor share neurobiolog social interact si sud may explain human access social treatment still experi relaps howev circuitri remain poor character due technic challeng studi complic natur si sud understand neural correl si sud import identifi cell type circuit associ si sud record manipul neural activ encod drug social reward time monitor unrestrain anim behavior allow reliabl drug self administr sa si miniatur fluoresc microscop miniscop ideal suit meet requir use gradient index grin lens imag deep brain structur implic sud miniscop combin genet encod report extract cell type specif inform mini review explor miniscop leverag uncov neural compon si sud advanc potenti therapeut intervent | D000083505;D019966 | T033;T048;T054 |
34,675,781 | genet transsynapt techniqu map neural circuit drosophila neural circuit compos popul neuron interconnect synaps carri specif function activ structur framework brain function impair often caus diseas nervous system understand comput function brain circuit crucial import identifi neuron circuit connect genet transsynapt techniqu provid opportun effici answer question techniqu label synaps across synaps unbias label synapt partner allow map neural circuit high reproduc throughput well provid genet access synapt connect neuron enabl visual manipul neuron simultan review focus three recent develop drosophila genet transsynapt tool detect chemic synaps highlight advantag potenti pitfal discuss futur develop need techniqu | D004330;D013569 | T204;T030 |
34,675,780 | disorgan oscillatori activ anim model schizophrenia schizophrenia chronic debilit disord divers symptomatolog includ disorgan cognit behavior despit consider research effort limit understand under brain dysfunct articl review potenti role oscillatori circuit disord particular focus hippocampus region encod sequenti inform across time space well frontal cortex sever mechanist explan schizophrenia propos loss oscillatori synchroni within brain region may underli symptom disord describ oscil affect sever anim model schizophrenia includ model genet risk matern immun activ mia model model nmda receptor hypofunct critic discuss evid disorgan oscillatori activ model focus gamma sharp wave rippl theta activ includ role cross frequenc coupl synchron mechan final focus phase precess oscillatori phenomenon wherebi individu hippocamp place cell systemat advanc fire phase background theta oscil phase precess import allow sequenti experi compress singl ms theta cycl known theta sequenc time window appropri induct synapt plastic describ disrupt phase precess could disorgan sequenti process therebi disrupt order storag inform similar dysfunct schizophrenia may contribut cognit symptom includ deficit episod memori work memori futur plan | D061212;D012559 | T048;T041 |
34,675,779 | synapsej autom synaps identif macro imagej electron microscopi repres gold standard detect synaps number limit prevent broad applic key method detect synaps immunostain marker pre post synapt protein infer synaps base upon apposit two marker immunostain imag techniqu improv allow identif synaps tissu analysi identif apposit facil lack tool accur identifi apposit delin macro use open sourc freeli avail imagej fiji analysi multichannel z stack confoc imag use high magnif high na object outlin two method identifi puncta either spars dens label imag puncta channel use elimin non appos puncta subsequ link cognat channel method appli analysi pre synapt marker bassoon two differ post synapt marker gephyrin n methyl aspart nmda receptor subunit nr use gephyrin inhibitori post synapt scaffold protein identifi inhibitori synaps basolater amygdala central amygdala arcuat ventromedi hypothalamus systemat variat set identifi paramet critic analysi identif specif overlap puncta allow correl morphometri data channel final extend analysi examin puncta overlap cytoplasm marker specif cell type distinct advantag beyond electron microscopi bassoon puncta restrict viral transduc pedunculopontin tegment nucleus ppn axon express yellow fluoresc protein nr puncta restrict tyrosin hydroxylas label dopaminerg neuron substantia nigra par compacta snc macro identifi bassoon nr overlap throughout imag restrict ppn snc connect thus extend avail analysi tool use studi synaps situ analysi code freeli avail open sourc allow innov | D045042;D013569 | T023;T030 |
34,675,516 | bombesin peptid conjug water solubl chitosan gallat new nanopharmaceut architectur rapid one pot synthesi prostat tumor target gold nanoparticl report herein bombesin peptid conjug water solubl chitosan gallat templat rapid one pot synthesi gold nanoparticl aunp capabl target receptor prostat cancer cell | D048271;D053768;D011471 | T191;T121;T073;T109 |
34,675,515 | penetr enhanc erythrocyt mimick nanoplatform via papaverin radiosensit radiotherapi rt recommend extens therapeut regimen cancer patient howev cancer radio resist result reduc oxygen level hypoxia tumor microenviron herein report therapeut strategi great enhanc treatment effect rt | D009369;D011838 | T039;T191;T121 |
34,675,514 | accur control deliveri temozolomid biocompat uio nh ultrasound enhanc antitumor efficaci attenu toxic treatment malign glioma glioma common malign primari brain tumour adult dismal prognosi temozolomid tmz clinic first line chemotherapi drug malign glioma present due poor aqueous solubl toxic effect tmz still ineffici limit clinic glioma treatment | D001932;D005909;D005910 | T191 |
34,675,513 | hollow ceo ros scaveng activ allevi coliti mice excess product reactiv oxygen speci ros induc high oxid stress one main caus coliti thus regard therapeut target coliti treatment nanomateri base therapeut strategi effect coliti howev previous elabor design materi exhibit limit applic due uncertain biocompat complic manufactur process | D003092 | T047 |
34,675,512 | recent advanc electrochem optic sensor detect tryptophan melatonin tryptophan melatonin pleiotrop molecul capabl influenc sever cellular biochem physiolog respons therefor sensit detect tryptophan melatonin pharmaceut human sampl crucial human well mass spectrometri high perform liquid chromatographi capillari electrophoresi common method tryptophan melatonin analysi howev method requir copious amount time money manpow novel electrochem optic detect tool subject intens research due abil offer better signal nois ratio high specif ultra sensit wide dynam rang recent research design sensit select electrochem optic platform use new surfac modif microfabr techniqu decor divers nanomateri uniqu properti detect tryptophan melatonin howev scarciti review articl address recent develop electrochem optic detect tryptophan melatonin provid critic object review high sensit tryptophan melatonin sensor develop past six year onward review principl perform limit sensor also address critic aspect sensit select limit rang detect fabric process time durabl biocompat final discuss challeng relat tryptophan melatonin detect present futur outlook | D015374;D008550;D049329 | T121;T109;T073;T125;T075;T059 |
34,675,511 | simpl rout complex lutein reduc graphen oxid nanocarri antioxid protect blue light excel physicochem properti graphen base materi includ graphen oxid go reduc go rgo offer signific technolog potenti multifunct nanomateri biomed field lutein type carotenoid form human macular pigment retina inhibit harm blue light contribut strengthen antioxid defens retin pigment epithelium cell | D006108 | T196;T109 |
34,675,510 | carfilzomib paclitaxel co load protein nanoparticl effect therapi pancreat adenocarcinoma therapeut efficaci pancreat adenocarcinoma pac combin therapi carfilzomib cfz paclitaxel ptx co load human serum albumin hsa nanoparticl nps examin | D000230;D053758;D010190 | T191;T073 |
34,675,509 | calcium enrich nanofibril cellulosepoloxam situ form hydrogel scaffold control deliveri system raloxifen hcl bone engin tempo oxid nanofibril cellulos tonfc origin agricultur wast sugar cane util prepar inject situ form hydrogel scaffold ih regen medicin | D020100;D020849 | T121;T122;T109 |
34,675,508 | tcpp isoliensinin nanoparticl mild temperatur phototherm therapi phototherm therapi ptt promis treatment tumor due advantag includ minim invas easi implement select local treatment howev singl ptt suffer sever limit constrain light penetr low deliveri effici typic lead heterogen heat incomplet elimin cancer cell therefor combin ptt therapi eg chemotherapi desir order achiev synergist effect cancer treatment | D006979;D053758 | T073;T061 |
34,675,507 | evalu effect silver nanoparticl experiment induc necrot enter broiler chicken clostridium perfringen associ necrot enter ne serious problem affect broiler product major global challeng reduc use antibiot poultri industri due negat impact public health one altern use nanoparticl nps overcom bacteri resist antibiot silver nanoparticl ag nps show strong antimicrobi activ | D003015;D004751;D053768;D011201 | T047;T073;T037 |
34,675,506 | glipr protect cigarett smoke induc airway inflamm via plauegfr signal chronic obstruct pulmonari diseas copd major health problem associ high mortal worldwid cigarett smoke cs exposur main caus copd glioma pathogenesi relat protein glipr play key role cell growth prolifer invas howev role glipr copd remain unclear | D036341;D008565;D029424 | T192;T116;T047;T123 |
34,675,505 | effect endobronchi coil exercis toler lung function patient sever emphysema retrospect cohort studi patient lung volum reduct endobronchi coil treatment ect patient sever emphysema shown modest improv exercis capac lung function clinic trial yet benefit procedur still unclear | D004646;D029424;D011656 | T047;T046 |
34,675,504 | quantifi econom impact delay multipl inhal tripl therapi initi patient copd retrospect cohort studi link electron medic record hospit administr data england assess earli multipl inhal tripl therapi mitt initi patient chronic obstruct pulmonari diseas copd reduc subsequ healthcar resourc util hcru direct medic cost acut exacerb copd aecopd | D057286;D029424 | T047;T170;T073 |
34,675,503 | human adipos deriv mesenchym stem cell amelior elastas induc emphysema mice mesenchym epitheli transit chronic obstruct pulmonari diseas copd worldwid problem high preval mortal howev fundament treatment amelior patholog chang copd lung recent adipos deriv mesenchym stem cell adsc attract attent field regen medicin repair damag organ moreov util treat respiratori diseas report anim model howev detail mechan adsc improv chronic respiratori diseas includ copd remain elucid examin whether human adsc hadsc amelior elastas induc emphysema whether hadsc differenti alveolar epitheli cell murin model copd | D004646;D059630;D029424;D011656 | T025;T046;T047 |
34,675,502 | predictor day copd exacerb readmiss prospect cohort studi readmiss follow copd exacerb common challeng clinic problem new approach predict readmiss requir help mitig risk develop novel intervent | D029424 | T047 |
34,675,501 | continu care assess within vertic integr care manag organ copd relat exacerb current littl research describ patient experi continu care immedi prior follow acut exacerb chronic obstruct pulmonari diseas aecopd analysi examin clinic characterist chronic obstruct pulmonari diseas copd relat medic pattern outpati visit aecopd | D029481;D019033;D029424 | T058;T047;T093 |
34,675,500 | mir p abca mir p arhgef axi involv sitosterol induc dual anti prolif effect bronchial epitheli cell chronic obstruct pulmonari diseas chronic obstruct pulmonari diseas copd progress irrevers respiratori diseas becom third lead caus death result enorm econom burden healthcar cost product loss worldwid thus urgent develop effect anti copd drug | D035683;D029424 | T047;T114;T123 |
34,675,499 | associ tight junction protein claudin lung function exacerb chronic obstruct pulmonari diseas chronic obstruct pulmonari diseas copd impos major healthcar burden tight junction protein claudin cldn may play protect role acut lung injuri role copd unclear investig relationship cldn copd evalu associ cldn clinic paramet copd includ exacerb | D057167;D029424 | T116;T047;T123 |
34,675,498 | averag systol blood pressur clinic outcom patient atrial fibril prospect data cool af registri hypertens associ incid atrial fibril af af relat complic investig associ averag systol blood pressur sbp outcom nationwid cohort asian patient non valvular atrial fibril nvaf | D001281;D020521 | T047;T046 |
34,675,497 | electron frailti index associ increas infect caus mortal among older patient primari lung cancer cohort studi assess whether electron frailti index efi independ associ caus mortal chemotherapi advers reaction among older chines patient lung cancer | D000073496;D008175 | T033;T191;T046;T184 |
34,675,496 | disabl death year follow taiwan longitudin studi age studi factor associ durat disabl death older adult moder sever disabl taiwan investig | D000203;D006233 | T080;T101;T056 |
34,675,495 | ad valu combin time go test walk speed grip strength predict recurr fall chines communiti dwell elder determin whether combin perform base model could exert better predict valu toward discrimin communiti dwell elder high risk fall recurr fall | D057187;D000072797 | T032;T056 |
34,675,489 | expand role pyridin dihydropyridin scaffold drug design pyridin base ring system one extens use heterocycl field drug design primarili due profound effect pharmacolog activ led discoveri numer broad spectrum therapeut agent us fda databas approv pharmaceut stem pyridin dihydropyridin includ isoniazid ethionamid tuberculosi delavirdin hivaid abirateron acet prostat cancer tacrin alzheim ciclopirox ringworm athlet foot crizotinib cancer nifedipin raynaud syndrom prematur birth piroxicam nsaid arthriti nilvadipin hypertens roflumilast copd pyridostigmin myasthenia gravi mani remark therapeut applic encourag research prepar larger number biolog activ compound decor pyridin dihydropyridin expand scope find cure ailment thus anticip myriad new pharmaceut contain two heterocycl avail forthcom decad review examin prospect high potent bioactiv molecul emphas advantag use pyridin dihydropyridin drug design cover recent develop date highlight ever expand role scaffold field medicin chemistri drug develop | D015195 | T090 |
34,675,486 | promis singl oral disintegr tablet co deliveri pitavastatin calcium lornoxicam use co process excipi formul character pharmacokinet studi statin import class drug help control hyperlipidemia one statin recent use pitavastatin calcium pita nevertheless report advers effect statin myopathi therefor combin statin non steroid anti inflammatori drug nsaid lornoxicam lorno help manag statin induc myopathi | D016503 | T074 |
34,675,484 | develop character ulvan polysaccharid base hydrogel film potenti wound dress applic ulvan natur polym type sulfat polysaccharid green seawe could potenti candid wound dress materi base support biopolym characterist antioxid antimicrobi activ | D001458 | T074 |
34,675,448 | low temperatur thermal treatment gas phase fluorotelom alcohol calcium oxid given extent per polyfluoroalkyl substanc pfas use commerci industri applic need evalu treatment option reduc environment emiss human ecolog exposur pfas becom necessari one specif chemic class pfas fluorotelom alcohol ftoh vapor pressur signific fraction expect present gas phase even ambient temperatur ftoh use varieti pfas applic includ synthesi materi coat use two complementari mass spectrometr method use calcium oxid cao examin low temperatur potenti low cost thermal treatment media remov destruct four gas phase ftoh vari molecular weight accomplish assess removaldestruct effici ftoh format fluorin byproduct function treatment temperatur c presenc cao compar thermal destruct treatment process evid pfas compound produc low temperatur c primari ftoh partial degrad temperatur c thermal treatment cao prevent format remov near secondari product | D000438;D005466 | T121;T109 |
34,675,440 | orthogon metabol framework one carbon util metabol engin often entail concurr engin substrat util central metabol product synthesi pathway inevit creat interdepend nativ metabol report altern approach use synthet pathway c bioconvers generat multicarbon product direct c unit henc orthogon host metabol network engin pathway base formyl coa elong forc reaction catalys enzym hydroxyacyl coa lyas use thermodynam stoichiometr analys evalu forc pathway variant includ aldos elong reduct aldehyd elong promis variant prototyp vitro vivo use non methylotroph bacterium escherichia coli demonstr convers format formaldehyd methanol various product includ glycol ethylen glycol ethanol glycer forc pathway also potenti integr host metabol synthet methylotrophi product nativ growth substrat demonstr two strain co cultur system | D053858 | T044;T169 |
34,675,434 | deep learn improv macromolecul identif cellular cryo electron tomogram cryogen electron tomographi cryo et visual spatial distribut macromolecul nanomet resolut insid nativ cell howev autom identif macromolecul insid cellular tomogram challeng nois reconstruct artifact well presenc mani molecular speci crowd volum present deepfind comput procedur use artifici neural network simultan local multipl class macromolecul train infer stage deepfind faster templat match perform better competit deep learn method identifi macromolecul various size synthet experiment dataset cellular cryo et data deepfind local membran bound cytosol ribosom rough mda ribulos bisphosph carboxylas oxygenas rough kda solubl complex photosystem ii rough kda membran complex accuraci compar expert supervis ground truth annot deepfind therefor promis algorithm semiautom analysi wide rang molecular target cellular tomogram | D000465;D000077321;D016571 | T170;T066 |
34,675,433 | develop character new swine model invas pneumococc pneumonia streptococcus pneumonia common microbi caus communiti acquir pneumonia current avail model sever pneumococc pneumonia mechan ventil anim mimic clinic condit critic ill patient studi endogen pulmonari flora healthi pig addit pig intra bronchial instil pneumonia serotyp character resist penicillin macrolid tetracyclin pig underw ventil h pig challeng pneumonia complet h studi wherea infect pig h clinic confirm pneumonia infect pig upon necropsi sampl lung tissu microbiologicalhistolog confirm pneumococc pneumonia control pig streptococcus sui staphylococcus aureus common encount pathogen lung tissu mean sem concentr cfug infect pig pneumonia found lung pig mean sem pulmonari concentr cfug bacteremia found infect pig pneumococc pneumonia confirm infect pig h pneumonia associ thrombocytopenia increas prothrombin time cardiac output vasopressor depend index decreas system vascular resist upon necropsi microbiologicalhistolog pneumococc pneumonia confirm pig therefor develop novel model penicillin macrolid resist pneumococc pneumonia mechan ventil pig bacteremia sever hemodynam compromis model could prove valuabl apprais pathogenesi pneumococc pneumonia effect associ macrolid resist outcom relat use new diagnost strategi antibiot complementari therapi | D011018 | T047 |
34,675,424 | singl cell profil protein chromatin access use phage atac multimod measur singl cell profil prove increas use character cell state regulatori mechan present studi develop phage atac assay transposas access chromatin massiv parallel droplet base method use phage display engin camelid singl domain antibodi nanobodi simultan singl cell measur protein level chromatin access profil mitochondri dna base clonal trace use phage atac multimod analysi primari human immun cell sampl multiplex intracellular protein analysi detect sar cov spike protein human cell popul final construct synthet high complex phage librari select antigen specif nanobodi bind cell particular molecular profil open avenu protein detect cell character screen singl cell genom | D001435;D000086382 | T047;T005;T067 |
34,675,423 | co vari neighborhood analysi identifi cell popul associ phenotyp interest singl cell transcriptom singl cell dataset grow sampl size critic need character cell state vari across sampl associ sampl attribut clinic phenotyp current statist approach typic map cell cluster assess differ cluster abund present co vari neighborhood analysi cna unbias method identifi associ cell popul greater flexibl cluster base approach cna character domin axe variat across sampl identifi group small region transcript space term neighborhood co vari abund across sampl suggest share function regul cna perform statist test associ sampl level attribut abund co vari neighborhood group simul show cna enabl sensit accur identif diseas associ cell state cluster base approach appli publish dataset cna captur notch activ signatur rheumatoid arthriti identifi monocyt popul expand sepsi identifi novel cell popul associ progress activ tuberculosi | D013601;D059467 | T086;T025;T081 |
34,675,422 | littl comfort food insecur among medic student sagamu southwest nigeria food insecur issu public health import world particular wors develop countri among disadvantag group food insecur higher among univers student medic student risk studi therefor determin preval factor associ food insecur among medic student sagamu nigeria | D013337 | T097 |
34,675,420 | bright stabl luminesc probe target engag profil live cell pace progress biomed research direct depend techniqu enabl quantit interrog interact protein biopolym small molecul ligand time resolv frster reson energi transfer tr fret assay platform offer high sensit specif howev pauciti access biocompat luminesc lanthanid complex essenti reagent tr fret base approach poor cellular permeabl limit broader adapt tr fret beyond homogen extracellular assay applic report develop corafluor new class macrotricycl terbium complex synthet readili access stabl biolog media exhibit photophys physicochem properti desir biolog studi valid perform corafluor cell free system identifi cell permeabl analog demonstr util quantit domain select character keap ligand well isoform select target engag profil hdac inhibitor live cell | D031541 | T059 |
34,675,415 | proteom analysi host pathogen interfac experiment cholera microbi cell surfac site critic microb host interact often control infect outcom defin set host protein present interfac challeng use surfac biotinyl approach coupl quantit mass spectrometri identifi quantifi bacteri host protein present surfac diarrheal fluid deriv vibrio cholera infant rabbit model cholera v cholera surfac coat numer host protein whose abund driven presenc cholera toxin includ c type lectin sp mice lack sp enhanc v cholera intestin colon sp product shape host pathogen transcriptom addit host protein anxa lpo zag bound v cholera also found recogn distinct taxa murin intestin microbiota suggest host factor may play role intestin homeostasi addit host defens | D040901 | T091 |
34,675,411 | singl molecul mechan fingerprint dna nanoswitch calip decod ident biomolecul trace sampl longstand goal field biotechnolog advanc dna analysi substanti affect clinic practic basic research correspond develop protein face challeng due relat complex inabl amplifi despit progress method mass spectrometri mass cytometri singl molecul protein identif remain high challeng object toward end combin dna nanotechnolog singl molecul forc spectroscopi creat mechan reconfigur dna nanoswitch calip capabl measur multipl coordin singl biomolecul atom resolut use optic tweezer demonstr absolut distanc measur ngstrm level precis dna peptid use multiplex magnet tweezer demonstr quantif relat abund mix sampl measur distanc dna label residu perform singl molecul fingerprint synthet natur peptid show discrimin within heterogen popul differ posttransl modif dna nanoswitch calip power access tool character distanc within nanoscal complex enabl new applic field singl molecul proteom | D036103;D000072760 | T059;T090 |
34,675,410 | phototherm nanofibr enabl safe engin therapeut cell nanoparticl sensit photopor upcom approach intracellular deliveri biolog combin high effici throughput excel cell viabil howev reli close contact nanoparticl cell translat toward clinic applic hamper safeti regulatori concern show light sensit iron oxid nanoparticl embed biocompat electrospun nanofibr induc membran permeabil phototherm effect without direct cellular contact nanoparticl phototherm nanofibr success use deliv effector molecul includ crispr cas ribonucleoprotein complex short interf rna adher suspens cell includ embryon stem cell hard transfect cell without affect cell prolifer phenotyp vivo experi furthermor demonstr success tumour regress mice treat chimer antibodi receptor cell express program cell death protein pd downregul nanofibr photopor short interf rna pd conclus cell membran permeabil phototherm nanofibr promis concept toward safe effici product engin cell therapeut applic includ stem cell adopt cell therapi | D016219 | T061 |
34,675,405 | make plant base diet review current concept propos standard plant base dietari intervent checklist within last decad plant base diet receiv increas interest potenti benefit human environment health concept plant base diet howev vari wide definit current definit rang exclus anim product diet includ meat fish dairi vari quantiti therefor main object review twofold investig research use term plant base diet nutrit intervent studi b type food plant base diet may includ search two databas found term plant base diet evok vari idea research clinician fifti percent retriev studi includ plant base dietari intervent complet proscrib anim product use term plant base diet interchang vegan diet contrast trial includ dairi product dietari intervent emphas semi vegetarian dietari pattern base specif exampl point usag umbrella term plant base diet may caus signific ambigu often encount incomplet descript plant base dietari intervent make comparison reproduc studi difficult consequ urg other use term plant base diet conjunct detail dietari descript facilit process provid templat standard plant base intervent report checklist final present review also highlight urgent need consensus definit term plant base diet content | D057189;D014676 | T033;T170;T061 |
34,675,403 | post exercis energi intak intens mode exercis matter systemat review meta analysi compar high intens interv moder intens continu protocol present systemat review meta analysi aim compar impact exercis intens mode high intens interv exercis hiie sprint interv exercis sie versus moder intens continu exercis mice post exercis ad libitum energi intak studi requir least two exercis condit hiie sie vs mice overal manuscript initi identifi met elig criteria random effect meta analysi reveal differ absolut energi intak pairwis comparison hiie p confid interv ci pairwis comparison sie p ci pairwis comparison versus mice neither relat energi intak p ci hiie p ci sie five one pairwis comparison respect subgroup analys method evalu ad libitum energi intak bodi mass sex volum time exercis non signific inspect studi two pairwis comparison report lower post exercis absolut energi intak hiie compar control crtl three pairwis comparison report lower absolut energi intak sie compar mice none pairwis comparison report differ protocol hiie sie versus mice relat energi intak conclus meta analysi show differ protocol absolut relat energi intak five pairwis comparison demonstr lower absolut energi intak hiie sie compar crtl mice studi need address key relev variabl exercis intens mode may impact energi intak | D000072696 | T061;T056 |
34,675,402 | pre probiot manag children autism gut issu review current evid manipul gut microbiom offer promis treatment option children autism spectrum disord asd function gastrointestin disord fgid common comorbid asd fgid link dysfunct microbiom gut brain mgb axi dysfunct bidirect network abil impact multipl host process includ gastrointestin gi function mood behaviour prebiot probiot supplement aim produc benefici shift within gut environ result favour chang microbi metabolit product gastrointestin function aim review investig gut microbiom therapeut target children asd evid util prebiot probiot synbiot ie prebiot probiot among cohort examin electron databas pubm web scienc medlin clinicaltrialsgov search use keyword phrase review literatur januari octob find suggest limit preliminari evid efficaci reliev gi distress improv asd associ behaviour alter microbiota composit reduc inflammatori potenti | D000067877;D001321;D005767;D000069196;D019936 | T048;T047;T007;T001 |
34,675,401 | effect high selenium lentil diet cardiovascular risk marker arsenic expos popul chronic arsenic exposur associ number system diseas includ cardiovascular diseas selenium shown promot arsenic excret bodi investig high selenium lentil diet effect blood pressur plasma lipid level arsenic expos popul conduct month random control dietari intervent trial particip | D001151;D002318;D027806;D012643 | T047;T121;T002;T123;T168;T131;T196 |
34,675,400 | translat advanc glycat end product age knowledg real world nutrit strategi advanc glycat end product age glycat protein lipid deriv complex metabol pathway involv pathophysiolog various diseas especi diabet diabet relat complic compound omnipres human life endogen exogen sourc despit well elucid diseas mechan littl known agesnutrit nexus circl clinic practic recommend review seek translat accumul knowledg biochemistri pathophysiolog age nutrit intervent base real world prescript | D048909;D003920 | T047 |
34,675,399 | ketoacidosi non diabet lactat woman case report literatur review report case year old woman develop non diabet ketoacidosi follow low carbohydr diet order lose weight activ breast feed newborn admit intens care unit sever metabol acidosi rapid recov refeed process lactat ketoacidosi special condit occur non diabet breastfeed women rare life threaten report highlight import nutrit educ lactat women post partum period | D000138;D007662 | T047;T046;T033 |
34,675,398 | novel evid methyl regul prognost biomark fto potenti therapeut target gastric cancer emerg evid indic n methyladenosin regul play crucial role cancer progress clinic signific gastric cancer gc thus far elucid | D019175;D015972 | T044;T045 |
34,675,395 | target transcript cycl cancer accur control gene express essenti normal develop dysregul transcript underpin cancer onset progress similar cell cycl regul rna polymeras ii driven transcript consid unidirect multistep cycl thousand uniqu transcript cycl occur concert within cell transcript cycl compris recruit initi paus elong termin recycl stage tight control coordin action transcript cyclin depend kinas cognat cyclin well oppos activ transcript phosphatas oncogen dysregul transcript entail defect control gene express either select loci global impact larg proport genom result depend core transcript machineri believ render transcript addict cancer sensit perturb transcript base find small molecul target transcript cyclin depend kinas associ protein hold promis treatment cancer util transcript cycl concept explain dysregul fine tune gene express process may drive tumorigenesi therapeut benefici respons may aris global select transcript perturb conceptu framework help explain tumour select transcript depend facilit ration design combin therapi | D009369;D014158 | T191;T045 |
34,675,394 | disentangl host microbiota complex hologenom research anim microbiota interact becom central topic biolog scienc relev basic eco evolutionari process appli question agricultur health howev anim host associ microbi communiti still seldom studi system fashion hologenom integr studi genet featur eukaryot host alongsid associ microb becom feasibl yet still underexploit approach overcom limit acknowledg biolog genet properti host microb along advantag disadvantag implement techniqu essenti design optim studi enabl major question biolog address | D064307 | T032;T001;T028 |
34,675,393 | bariatr surgeri ophthalmologist need know incid bariatr surgeri increas due obes one top public health challeng bariatr relat ophthalm chang potenti new clinic area knowledg increas publish evid post bariatr complic experienc patient identifi clinician review avail literatur summaris differ complic potenti recommend search strategi conduct pubm cochran medlin embas alli complementari medicin dh data databas look paper answer research question ophthalmolog complic patient bariatr surgeri search gave total relev paper bariatr surgeri particular subtyp caus direct bypass nutrient stomach lead nutrit defici vitamin crucial proper function bodi system specialis cell manifest ophthalmolog corneal ulcer nyctalopia conjunctiv xerosi thiamin level also deplet lead wernick encephalopathi pre exist diabet retinopathi also note worsen sub acut although evid conflict patient undergo surgeri treat idiopath intracrani hypertens would reduc iop resolv papilloedema comorbid obes like hb ac level obstruct sleep apnoea metabol syndrom also resolv post surgeri histori take remain cornerston medic practic evid suggest consider pre surgeri screen ophthalm patholog post oper monitor diseas progress real world data need continu analys creat definit manag pathway help clinician recognis ophthalm complic earli improv patient outcom | D050110;D000072163;D020181 | T097;T047;T061 |
34,675,390 | dynam transcript reprogram lead immunotherapeut vulner myeloma extens evid genet variat basi treatment resist sourc variat result cellular plastic use multipl myeloma exampl incur lymphoid malign show cancer cell modul lineag restrict adapt enhanc usag employ cell intrins divers surviv treatment escap use singl cell transcriptom chromatin access profil show distinct transcript state co exist individu cancer cell differenti transcript regulon usag enhanc rewir underli altern transcript state demonstr exposur standard treatment promot transcript reprogram differenti enhanc recruit simultan reduc development potenti import treatment generat distinct complement action immunotherapi target cxcr exploit overcom treatment resist studi therefor delin transform cellular plastic under drug resist immuno oncolog therapeut opportun | D065150;D007167;D014158 | T043;T062;T061;T045 |
34,675,385 | bifidobacterium speci associ breastfeed produc aromat lactic acid infant gut breastfeed profound shape infant gut microbiota critic earli life immun develop gut microbiota impact host physiolog various way product metabolit howev breastmilk depend microbi metabolit mediat host microbiota interact current known demonstr breastmilk promot bifidobacterium speci convert aromat amino acid tryptophan phenylalanin tyrosin respect aromat lactic acid indolelact acid phenyllact acid hydroxyphenyllact acid via previous unrecogn aromat lactat dehydrogenas aldh abil bifidobacterium speci convert aromat amino acid lactic acid deriv confirm use monocolon mice longitudin profil faecal microbiota composit metabolom danish infant n birth month age show faecal concentr aromat lactic acid correl posit abund human milk oligosaccharid degrad bifidobacterium speci contain aldh includ bifidobacterium longum b breve b bifidum demonstr faecal concentr bifidobacterium deriv indolelact acid associ capac sampl activ vitro aryl hydrocarbon receptor ahr receptor import control intestin homoeostasi immun respons final show indolelact acid modul ex vivo immun respons human cd cell monocyt dose depend manner act agonist ahr hydroxycarboxyl acid receptor hca find reveal breastmilk promot bifidobacterium speci produc aromat lactic acid gut infant suggest microbi metabolit may impact immun function earli life | D000069196 | T007;T001 |
34,675,381 | endogen dopamin releas human brain pharmacodynam biomark evalu new gpr agonist tak c phno pet use positron emiss tomographi pet earli phase develop novel drug target central nervous system well establish evalu brain penetr target engag howev novel target involv suitabl pet ligand alway avail demonstr altern approach evalu attenu amphetamin induc synapt dopamin releas novel agonist orphan g protein coupl receptor gpr tak gpr agon novel candid mechan treatment schizophrenia disord associ social cognit dysfunct ten healthi volunt underw c phno pet baselin twice receiv oral dose amphetamin mgkg one post amphetamin scan subject preced singl oral dose tak mg five mg five particip amphetamin induc signific decreas c phno bind potenti relat non displac compon bp nd region examin consist increas synapt dopamin releas pre treatment tak signific attenu amphetamin induc reduct bp nd priori defin region putamen ventral striatum respect reduct bp nd general higher mg mg tak dose differ dose reach statist signific putamen find suggest tak enter human brain interact gpr affect endogen dopamin releas c phno pet practic method detect effect novel drug brain dopaminerg system healthi volunt earli stage drug develop | D004298;D018491 | T121;T109;T123 |
34,675,380 | region specif clinic correl cortic gaba alter posttraumat stress disord gamma aminobutyr acid gaba metabol implic posttraumat stress disord ptsd may alter prefront limbic brain region involv arous regul studi use proton magnet reson spectroscopi mrs test hypothesi ptsd trauma expos non ptsd comparison tenc adult signific differ gaba healthi comparison hc subject two brain area implic arous medial prefront cortex insula control brain area posterior tempor cortex also examin whether gaba alter correl hyperarous dissoci symptom one hundr fourteen particip ptsd tenc hc underw mrs medial prefront right insular right posterior tempor cortic gaba plus macromolecul signal gaba normal creatin cr clinician administ ptsd scale measur hyperarous symptom includ sleep disrupt dissoci experi scale assess dissoci symptom ptsd tenc particip signific lower mpfc gabacr hc particip deficit signific correl greater dissoci compar hc ptsd patient tenc signific lower insula gabacr total hyperarous symptom sleep disrupt signific associ gabacr alter either region find point lower gaba cortic area implic arous regul ptsd suggest gaba alter associ symptom trauma relat psychopatholog alway biomark diagnosi find also add evid dissoci distinct neural correl within ptsd includ high excit medial prefront cortex | D013313 | T048 |
34,675,379 | mineralocorticoid receptor antagonist diabet kidney diseas mechanist therapeut effect chronic kidney diseas ckd lead complic type diabet td current therapi limit ckd progress develop cardiovascular diseas cvd includ angiotensin convert enzym inhibitor angiotensin ii receptor blocker sodium glucos co transport sglt inhibitor despit introduct therapeut import residu risk ckd progress cardiovascular death remain patient td mineralocorticoid receptor antagonist mras promis therapeut option diabet kidney diseas dkd owe report effect mineralocorticoid receptor activ inflammatori cell podocyt fibroblast mesangi cell vascular cell preclin studi mras consist reduc albuminuria ckd progress activ fibrot inflammatori pathway dkd clinic studi similar demonstr steroid mras lead albuminuria reduct compar placebo although hyperkalaemia major secondari effect non steroid mras carri lower risk hyperkalaemia steroid mras larg fidelio dkd clinic trial show non steroid mra finerenon also slow ckd progress reduc risk advers cardiovascular outcom compar placebo patient td encourag non steroid mras anti albuminur properti dkd whether combin mras renoprotect drug sglt inhibitor might provid addit protect effect warrant investig | D003924;D003928 | T047 |
34,675,378 | structur insight evolut rag recombinas adapt immun jaw vertebr reli assembl antigen receptor gene recombin activ gene rag rag collect rag recombinas reaction known v j recombin extens biochem structur evid indic rag v j recombin evolv compon rag like ragl transpos element process known transposon molecular domest review describ recent advanc understand function structur transit occur rag evolut use structur rag ragl enzym trace evolutionari adapt yield rag recombinas exquisit regul cleavag activ multilay array mechan suppress transposit describ chang mode dna bind alter dynam protein dna complex singl amino acid mutat modular design like enabl rag famili enzym surviv spread genom eukaryot advanc highlight insight gain view evolut vertebr immun len compar genom analys coupl structur biolog biochemistri | D018398;D045522 | T116;T126;T123 |
34,675,376 | high perform thermoelectr challeng practic devic thermoelectr materi potenti employ solid state devic harvest wast heat convert electr power therebi improv effici fuel util spectacular increas effici materi achiev past decad rais expect regard use thermoelectr generat various energi save energi manag applic especi mid high temperatur c howev sever import issu prevent success thermoelectr generat commerci remain unresolv good part lack research roadmap | D004560;D006358 | T070 |
34,675,372 | associ weight advers outcom score raceethn women neonat examin associ weight advers outcom score wao raceethn among larg divers popul base cohort women neonat unit state | D044383;D005006 | T098;T102 |
34,675,371 | surviv short term respiratori outcom g infant initi intub mm vs mm endotrach tube compar surviv short term respiratori outcom infant weigh g initi intub mm versus mm endotrach tube ett | D007235;D007442 | T047;T061 |
34,675,370 | vitamin status low birth weight infant respons vitamin intak nicu stay prospect cohort studi evalu vitamin status low birth weight vlbw infant respons vitamin intak | D007363;D014808 | T047;T093;T073 |
34,675,369 | associ matern bmi gestat weight gain health outcom offspr age year secondari analys randomis control trial exercis pregnanc examin associ mid pregnanc matern bodi mass index bmi excess gestat weight gain gwg offspr health follow data avail mother child pair year pair year follow up clinic assess includ bodi composit fast blood test age year increas matern bmi mid gestat associ greater weight standard deviat score sds offspr p observ associ excess gwg age year greater matern bmi associ increas weight sds p bmi sds p total bodi fat percentag p children irrespect matern bmi children born mother excess gwg greater abdomin adipos p less favour lipid profil lower hdl c higher triglycerid year matern bmi excess gwg compound advers associ offspr adipos compar offspr mother overweightobes plus excess gwg children normal weight mother adequ excess gwg sds lighter p p respect sds leaner p p respect greater matern bmi mid pregnanc excess gwg independ associ increas adipos offspr year | D000067576;D000078064 | T058;T033;T078 |
34,675,367 | design synthesi biolog evalu molecular model studi pyrazol benzofuran hybrid new glucosidas inhibitor work new deriv biphenyl pyrazol benzofuran hybrid design synthes evalu vitro enzymat assay inhibitori effect glucosidas activ newli identifi inhibitor found four eighteen fold activ ic valu rang compar standard drug acarbos ic limit structur activ relationship establish kinet bind studi indic activ compound e act competit inhibitor glucosidas k molecular dock also perform find interact mode respons desir inhibitori activ expect pharmacophor featur use design hybrid involv interact activ site enzym addit molecular dynam simul show compound e orient vertic activ site mouth bottom stabil enzym domain interact interfac domain domain b back side activ site acarbos form non bind interact residu belong domain enzym | D015195 | T090 |
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