PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,671,851 | second degre av block type mobitz wenckebach year old man dilat cardiomyopathi year old man dilat cardiomyopathi left ventricular eject fraction unremark left ventricular biopsi develop atrioventricular conduct abnorm av block ii type wenckebach exercis test | D054537;D002311 | T047 |
34,671,850 | posterior fossa decompress children chiari malform hydrocephalus chiari malform cmi hydrocephalus often coexist clear understand caus effect relationship absenc associ etiolog tradit teach treat hydrocephalus first part minim risk cerebrospin fluid csf leak cmi decompress set elev icp describ seri consecut pediatr patient cmi hydrocephalus major manag posterior fossa decompress | D001139;D006849 | T033;T047;T019 |
34,671,849 | efficaci outpati infus therapi pediatr patient postconcuss headach determin relat efficaci intraven therapi postconcuss headach pediatr popul compar oral therapi | D018718 | T061 |
34,671,848 | diffusion kurtosi imag possibl prognost marker cervic incomplet spinal cord injuri outcom prospect pilot studi spinal cord injuri sci associ substanti chronic morbid mortal routin imag techniqu weight magnet reson imag mri effect predict neurolog defici grade outcom diffusion kurtosi imag dki mr imag techniqu provid microstructur inform biolog tissu longitudin prospect studi assess dki metric acut traumat sci therefor purpos studi establish dki protocol acut sci correl dki metric function neurolog outcom patient | D056324;D013119 | T037;T060 |
34,671,846 | enhanc landfil character use altern analyt model diffus test landfil extens use wast deposit big citi world therefor consider larg urban area contamin threat engin solut appli prevent contain soil water contamin often involv applic liner low permeabl barrier made materi compact clay geomembran mani liner applic reduc rate seepag expect diffus prove relev domin process contamin transport normal diffus paramet assess singl reservoir pure diffus test contamin solut place satur soil sampl solut concentr monitor time tempor variat concentr measur process back calcul diffus paramet standard paper analyt model diffus transport contamin revisit consid initi boundari condit pure diffus test model contamin solut reservoir includ analysi domain equival contamin soil layer analyt solut reli seri evalu may drawback everyday engin situat therefor build high accuraci exponenti approxim solut expedit evalu procedur propos provid reason estim fit paramet also order illustr applic new solut test dataset soil around jockey club landfil jcl site one major landfil latin america model discuss possibl issu consid linear isotherm model sorption characterist soil indic convex isotherm linear model may lead overestim valu diffus paramet | D012037 | T057 |
34,671,845 | iccm root cari lesion stage under depth toward pulp vitro studi histolog evalu examin relationship iccm intern cari classif manag system featur root cari lesion under depth lesion toward pulp order control bias studi follow tailor document risk bias assess rob tool recent publish pilot studi show outlin pulp much clearer horizont compar vertic section lesion p histolog stereomicroscop sm assess lesion depth toward pulp influenc cut direct p | D003731;D017213 | T033;T047 |
34,671,843 | detect frame mutat famili insert sequenc phospholipid phosphatidylglycerol synthas gene pgsa high level daptomycin resist corynebacterium striatum emerg high level daptomycin dap resist hldr corynebacterium striatum report result loss function point mutat prematur stop codon mutat respons gene pgsa herein describ novel detect hldr c striatum clinic isol insert corrobor caus destruct pgsa gene isol hldr c striatum critic ill patient under mycosi fungoid treat dap day sequenc investig insert discov split pgsa hldr c striatum strain may caus disrupt phospholipid phosphatidylglycerol pg product futur studi survey preval mediat gene inactiv among hldr c striatum clinic isol | D009154 | T045 |
34,671,841 | long term impact low cost paediatr intussuscept air enema reduct simul base educ programm low middl incom countri intussuscept one commonest caus bowel obstruct infant infant low middl incom countri lmic undergo invas oper intervent support simul base educ sbe air enema ae non oper techniqu introduc myanmar studi assess long term outcom | D007443;D019651 | T047;T061 |
34,671,837 | genet evolut situ follicular neoplasia posit aggress b cell lymphoma situ follicular neoplasia isfn q q precursor lesion follicular lymphoma fl turn transform diffus larg bcell lymphoma dlbcl dlbcl aris de novo precursor lesion known given high frequenc transloc de novo dlbcl well investig whether also aris isfn without fl intermedi step | D008224;D016403 | T191 |
34,671,833 | identif intratumor fluid contain area magnet reson imag predict prognosi patient pancreat ductal adenocarcinoma curat resect compar prognosi pancreat ductal adenocarcinoma pdac curat resect accord type intratumor fluid contain area identifi mri | D021441;D010190 | T191 |
34,671,832 | radiom model base shear wave elastographi assess axillari lymph node status earli stage breast cancer develop valid ultrasound elastographi radiom nomogram preoper evalu axillari lymph node aln burden earli stage breast cancer | D001943;D054459 | T191;T060 |
34,671,831 | gender differ examin behavior th grade medic student result observ studi ecg e learn comput assist teach becom increas import acquir new knowledg skill medic curricula consequ gender characterist person trait academ perform elearn examin difficult forecast studi investig gender relat differ examin behavior among undergradu medic student take web base quiz | D003194;D004504;D013337 | T097;T065 |
34,671,830 | psychocardiolog assess acut phase takotsubo syndrom somat depress disord resili ill percept analyz psychocardiolog profil clinic characterist acut phase takotsubo syndrom tts | D003866;D054549 | T048;T047 |
34,671,829 | direct cardiovascular complic indirect collater damag covid pandem review coronavirus diseas covid pandem caus sever acut respiratori syndrom coronavirus sar cov put heavi strain healthcar system around globe high number infect patient pre exist cardiovascular diseas major risk factor sever clinic cours covid associ advers outcom covid may direct exacerb under heart diseas frequent aggrav cardiovascular complic includ arteri venous thromboembol event malign arrhythmia myocardi injuri addit direct cardiac manifest covid patient cardiovascular diseas face indirect consequ pandem respect resourc healthcar system need redirect cope high number infect patient consecut substanti decreas cardiac procedur report pandem lower number coronari angiographi devic implant worldwid consequ increas number hospit cardiac arrest late comer subacut myocardi infarct patient present cardiogen shock preshock observ mainten high qualiti cardiac care avoid reduct cardiac servic utmost import especi time pandem | D000086382;D002318;D009203 | T047;T067 |
34,671,828 | score apprais paleolith diet risk cardiovascular diseas mediterranean prospect cohort assess associ score apprais adher paleodiet risk cardiovascular diseas cvd mediterranean cohort | D002318;D038441 | T047;T061 |
34,671,824 | biofilm format staphylococcus epidermidi imag use atmospher scan electron microscopi staphylococcus epidermidi gram posit bacteria form biofilm around implant devic develop infect chronic state recent reveal microvesicl import role biofilm format intercellular communic among bacteria howev biofilm format staphylococcus epidermidi relat microvesicl secret poor understood difficulti requir preserv delic water rich morpholog biofilm high resolut observ success imag microvesicl secret staphylococcus epidermidi subsequ process integr biofilm use liquid phase imag use atmospher scan electron microscopi asem biofilm cell connect nanotub like structur attach microvesicl surround extracellular polymer substanc cell cultur asem specimen holder aldehyd fix stain use posit charg nanogold label andor use nation center microscopi imag research method sampl immers aqueous radic scaveng glucos buffer imag invert sem asem inform regard morpholog microvesicl nanotub like fibril biofilm form staphylococcus epidermidi expect use elucid biolog mechan biofilm format develop medicin biofilm associ infect | D018441 | T007 |
34,671,823 | health relat qualiti life patient recent fractur attend fractur liaison servic year follow studi studi explor cours health state util valu year patient recent fractur attend fractur liaison servic suggest overal chang health relat qualiti life signific although signific improv observ month compar baselin | D050723;D011788 | T037;T078 |
34,671,822 | sleev gastrectomi transit bipartit seri patient mild obes earli effect safeti outcom least metabolicbariatr procedur propos global formal endors newer procedur sleev gastrectomi transit bipartit sg tb appear mark reduc weight improv metabol syndrom relat simpl technic protect long term nutrit stabil aim investig sg tb effect safeti | D003924;D015390;D006973;D010535;D009767 | T047;T060;T061 |
34,671,821 | gender trend authorship pediatr radiolog public impact covid pandem coronavirus diseas covid pandem heighten exist gender differ academ product medicin discrep repercuss women academ due pandem includ fewer public potenti impact academ advanc | D000086382;D011871 | T091;T047;T067 |
34,671,820 | eanm guidelin radiosynoviorthesi radiosynoviorthesi rso use intraarticular applic beta particl emit radiocolloid decad use local treatment inflammatori joint diseas inject radiopharmaceut phagocyt superfici macrophag synovi membran result sclerosi fibrosi former inflam tissu final lead reduc joint effus allevi joint pain | D009683 | T091 |
34,671,818 | dynam hmbg high mobil group box radiochemotherapi correl outcom hnscc patient high mobil group box hmgb protein describ consensus marker immunogen cell death icd cancer person treatment need biomark adapt dose prescript concomit chemotherapi follow radiat oncolog thus investig level hmgb plasma patient head neck squamous cell carcinoma hnscc cours radiochemotherapi follow correl oncolog outcom clinic confound | D024243;D006258 | T116;T191;T123 |
34,671,817 | nineteen percent meniscus repair revis failur frequent occur second postop year systemat review meta analysi minimum follow year meniscus repair gain increas interest last two decad loss meniscus tissu predispos earli onset knee arthriti although mani report meniscus repair outcom short term studi data long term outcom meniscus repair still scarc purpos meta analysi evalu overal failur rate meniscus repair minimum follow year addit possibl factor influenc meniscus repair outcom assess | D000070598;D000072600;D000070600 | T023;T037 |
34,671,816 | phytotox effect antibiot terrestri crop plant wild plant systemat review review examin state knowledg phytotox effect antibiot terrestri crop plant wild non crop plant goal evalu differ sensit import environment risk assess antibiot current consid potenti effect crop speci wild speci overal analys dataset consist antibiot plant speci endpoint combin germin mgl dataset plant growth elong biomass mgkg ec ec paramet compar use quotient approach geometr mean th percentil crop data divid wild data quotient elong growth suggest wild speci sensit crop biomass growth suggest quit contrari howev data dataset came wild speci prevent definit conclus merg crop wild data evalu differ sensit among class antibiot plant famili found use linear mix effect model post hoc test plant sensit phenicol least sensit macrolid tetracyclin work must conduct gain better understand phytotox effect antibiot terrestri wild plant subsequ assess whether current approach environment risk assess antibiot suffici protect plant biodivers | D000900;D018525 | T195;T121;T038 |
34,671,814 | mdf sa ddi predict drug drug interact event base multi sourc drug fusion multi sourc featur fusion transform self attent mechan one main problem joint use multipl drug may caus advers drug interact side effect damag bodi therefor import predict potenti drug interact howev avail predict method predict whether two drug interact wherea method predict interact event two drug accur predict interact event two drug use research studi mechan interact two drug present studi propos novel method mdf sa ddi predict drug drug interact ddi event base multi sourc drug fusion multi sourc featur fusion transform self attent mechan mdf sa ddi main compos two part multi sourc drug fusion multi sourc featur fusion first combin two drug four differ way input combin drug featur represent four differ drug fusion network siames network convolut neural network two auto encod obtain latent featur vector drug pair two auto encod structur main differ number neuron input layer two auto encod use transform block includ self attent mechan perform latent featur fusion conduct experi three differ task two dataset small dataset area precis recal curv aupr f score method task reach respect better state art method larg dataset aupr f score method task reach respect task task two dataset method also achiev better perform state art method import case studi five ddi event conduct achiev satisfactori perform sourc code data avail https githubcomshenggenglinmdf sa ddi | D064420;D016571 | T046;T170;T037 |
34,671,812 | tobacco tracker new tool support colleg smoke tobacco free polici univers communiti member critic success smoke tobacco free stf polici present studi evalu chang social enforc relat attitud behavior follow introduct new onlin tobacco tracker tool two univers set | D061845;D014028 | T033;T069;T064 |
34,671,811 | hindgut ferment starch greater puls grain cereal grain grow pig nutrit valu starch major sourc dietari energi pig vari depend suscept digest botan origin starch determin starch structur therefor digest compar digest starch fiber gross energi ge crude protein amino acid aa character undigest starch grain grow pig seven ileal cannul barrow initi bodi weight kg fed six diet contain one six test ingredi three puls grain zero tannin faba bean green field pea mix cultivar chickpea three cereal grain hull barley hard red spring wheat hybrid yellow dent corn n free diet latin squar mainten digest energi grain sampl ground hammer mill mm screen amylos content rang puls grain cereal grain appar ileal digest aid starch greater p cereal puls grain lowest p faba bean follow field pea chickpea howev appar total tract digest attd starch test grain close appar hindgut ferment ahf attd aid starch greater p puls grain cereal grain ahf total dietari fiber tend greatest p corn lowest wheat ahf ge greater p puls grain cereal grain result greater p digest energi de contribut hindgut ferment puls grain cereal grain vs mcalkg wheat greatest standard ileal digest total aa p confoc laser scan microscopi imag reveal starch granul puls grain entrap protein matrix scan electron microscopi imag starch granul larger faba bean field pea cereal grain digesta sampl reveal pin hole surfac crack starch granul corn wheat respect conclus hindgut ferment starch fiber greater puls grain cereal grain result greater de valu despit lower ileal de puls grain cereal grain defin digest ferment fraction starch may enhanc accuraci equat predict net energi valu feedstuff | D002523;D013213 | T121;T168;T109;T123 |
34,671,810 | elev c reactiv protein alzheim diseas without depress older adult find health retir studi examin associ differenti diagnos major stroke probabl alzheim diseas ad mix ad c reactiv protein crp older adult without depress secondari data analys examin associ blood base measur probabl peripher inflamm use crp collect dri blood spot health retir studi nation repres sampl individu age older valid pattern recognit algorithm util identifi cognit declin indic probabl ad mix ad major stroke negat binomi regress util model concentr serolog crp averag particip n year old femal non hispan white mix ad particip mgdl increas crp compar unimpair particip control demograph health behavior comorbid mix ad time increas odd high crp odd ratio analys stratifi depress adult mix ad without depress addit mgdl increas crp se p compar unimpair adult ad without depress mgdl increas crp se p age associ increas crp nondepress older adult depress adult major stroke mgdl decreas crp se p control hypertens alcohol drinksbeverag per week smoke status concentr model reveal particip major stroke probabl ad probabl mix ad without depress signific higher crp concentr compar unimpair older adult | D000544;D060825 | T048;T047 |
34,671,809 | improv thermost proteinas k recogn synergist effect rosetta foldx approach proteinas k prk proteolyt enzym wide use industri applic howev poor stabil sever limit use prk work use two structur guid ration design method rosetta foldx modifi prk thermost fifti two singl amino acid convers mutant construct base softwar predict residu could affect protein stabil experiment character reveal mutant exhibit enhanc thermost top four variant dv ty sq sq show improv half live c fold parent enzym respect also found select mutat predict method could increas predict accuraci either method alon share predict mutat result higher thermost addit provid promis new variant prk industri applic find also show combin program may synergist improv predict accuraci | D000596;D011506 | T116;T121;T123 |
34,671,807 | somat variant analysi suit copi number variat clonal visual onlin platform larg scale singl cell genom recent advanc singl cell copi number variat cnv analysi play essenti role address intratumor heterogen identifi tumor subgroup restor tumor evolv trajectori singl cell scale inform visual copi number analysi result boost product scientif explor valid share sever singl cell analysi figur effect visual understand singl cell genom publish articl softwar packag howev almost lack real time interact hard reproduc moreov exist tool time consum memori intens reach larg scale singl cell throughput present onlin visual platform singl cell somat variant analysi suit scsvas real time interact singl cell genom data visual scsvas specif design larg scale singl cell genom analysi provid arsenal uniqu function upload specifi input file scsvas deploy onlin interact visual automat user may conduct scientif discoveri share interact visual download high qualiti public readi figur scsvas provid versatil util manag investig share publish singl cell cnv profil envis onlin platform expedit biolog understand cancer clonal evolut singl cell resolut visual public host https scdeepomicsorg | D056915;D012984 | T073;T045;T170;T086;T090 |
34,671,806 | bilater peron nerv paralysi agricultur worker three case report peron nerv injur due direct trauma non traumat caus injuri most occur fibular head neck most unilater injuri most result prolong squat cross leg sit sit one foot tuck leg report present three agricultur worker histori prolong squat develop bilater foot drop due bilater peron nerv injuri two recov almost complet physic therapi one remain disabl agricultur worker advis avoid prolong squat h extend knee strengthen muscl around knee order prevent neuropathi | D010523;D020427 | T033;T047 |
34,671,804 | japan societi neuro oncolog guidelin diagnosi treatment central nervous system germ cell tumor primari cns germ cell tumor gcts rare neoplasm predomin observ pediatr young adult popul line hypothesi primordi germ cell cell origin histopatholog examin patholog involv divers rang compon mirror embryogen development dimens chemotherapi radiotherapi mainstay treatment surgeri limit role diagnosi debulk residu tissu treatment better manag achiev recent decad modifi radiat coverag select appropri chemotherapi standard treatment remain challeng part due low volum case encount institut incid higher east asia includ japan japan societi neuro oncolog establish multidisciplinari task forc creat evid base guidelin cns gcts guidelin provid recommend multipl dimens clinic manag cns gcts particular focus diagnost measur includ serum marker treatment algorithm includ surgeri radiotherapi chemotherapi investig import area treatment recurr case long term follow protocol long term sequela guidelin serv purpos help healthcar profession keep date current knowledg standard manag patient rare diseas daili clinic practic well drive futur translat clinic research recogn unmet need concern tumor | D016543;D009373 | T191 |
34,671,803 | adenovirus prevent dsrna format promot effici splice viral rna eukaryot cell recogn intracellular pathogen pattern recognit receptor includ sensor aberr nucleic acid structur sensor doubl strand rna dsrna known detect replic intermedi rna virus long suggest anneal mrna symmetr transcript top bottom strand dna virus genom produc dsrna infect support hypothesi near dna virus encod inhibitor dsrna recognit pathway howev direct evid dna virus produc dsrna lack contrari dogma show nuclear replic dna virus adenovirus adv produc detect level dsrna infect contrast abund dsrna detect within nucleus cell infect adv mutant defect viral rna process presenc nuclear dsrna cytoplasm dsrna sensor pkr reloc activ within nucleus accumul viral dsrna occur late phase infect unsplic viral transcript form intronexon base pair top bottom strand transcript propos dna virus activ limit dsrna format promot effici splice mrna process thus avoid detect restrict host innat immun sensor pathogen nucleic acid | D000256;D012326;D012367 | T114;T005;T045 |
34,671,801 | toward machin learn discoveri dual antibacteri drug nanoparticl system artifici intelligencemachin learn aiml algorithm may speed design dadnp system form antibacteri drug ad nanoparticl np work use ifptml inform fusion perturb theori pt machin learn ml algorithm first time studi larg dataset putat dadnp system compos chembl ad assay np assay vs multipl bacteria speci train altern model linear discrimin analysi lda artifici neural network ann bayesian network bnn k nearest neighbour knn algorithm ifptml lda model simpler valu sp sn train k case valid k case seri ifptml ann knn model notabl complic even balanc sn sp auroc seri also carri simul calcul expect behavior putat dadnp differ biolog assay putat dadnp studi form differ drug multipl class np type coat addit test valid addit model dadnp complex experiment synthet biolog test report paper dadnp show valu mic g ml cutoff use better mic ad np alon synergist addit effect assay involv dadnp complex type np coat materi np size rang nm vs differ antibiot bacteria speci ifptml lda model classifi correct dadnp complex biolog activ ifpmtl addit strategi may becom use tool assist design dadnp system antibacteri therapi take consider inform ad np compon separ | D053758;D004364 | T121;T073 |
34,671,799 | conduct polyacrylamid hydrogel enabl dispers enhanc mxene chitosan assembl high stretchabl sensit wearabl skin mxene recogn ideal materi sensit wearabl strain sensor uniqu advantag conduct hydrophil mechan properti howev convent hydrogel sensor util mxene conduct materi inevit encount excess accumul mxene nanosheet process synthesi limit electron transmiss reduc conduct concurr weaken mechan capabl sensit sensor herein construct dispers enhanc mxene hydrogel demh chitosan induc self assembl strategi first time charg transfer carri flow materi collect materi microstructur thus high interconnect mxene chitosan network provid fast transport channel electron demh exhibit excel conduct sensibl simultan besid electrostat self assembl mxene chitosan supramolecular interact mxene chitosan polyacrylamid chain segment result excel mechan strength flexibl demh furthermor introduct chitosan possess high densiti posit charg group mxene semiconduct properti also endow sensor versatil self adhes properti antibacteri activ work develop simpl cut price strategi combin mxene unaggreg hydrogel sensor high conduct sensibl flexibl simpl inexpens strategi avoid self stack two dimension conduct materi propos pave way broad rang applic electron skin human motion detect intellig devic | D000076251 | T073 |
34,671,797 | dialdehyd pectin crosslink hirudin load decellular porcin pericardium improv matrix stabil enhanc anti calcif anticoagul bioprosthet heart valv conveni effect cure heart valv diseas defect combin transcathet valv technolog bioprosthet heart valv bhvs origin decellular porcin pericardium pp broad use clinic unfortun clinic avail bhvs crosslink glutaraldehyd ga challeng long term toler degen structur chang even failur owe synergist impact multitudin element cytotox calcif immun respons etc work dialdehyd pectin ap prepar oxid dihydroxi pectin sodium period hereaft ap fix pp model obtain crosslink pp ap high aldehyd content mmol g acquir excel mechan properti outstand biocompat improv hemocompat ap fix pp natur specif inhibitor thrombin hirudin introduc achiev surfac modif ap fix pp feasibl crosslink function ap fix pp potenti leaflet materi bhvs exhaust systemat evalu vitro studi found hirudin load ap fix pp ap hirudin pp synchron achiev effect fixat collagen high effect anticoagul good huvec cytocompat vivo result reveal ap hirudin pp specimen recruit minimum immun cell implant experi also present excel anti calcif effect overal ap hirudin pp endow competit collagen stabil compar ga fix pp excel hemocompat good huvec cytocompat low immunogen outstand anti calcif suggest ap hirudin pp might promis altern ga fix pp exhibit bright prospect clinic applic bhvs | D001705;D006350 | T074 |
34,671,794 | inject hydrogel mediat deliveri gene engin adipos deriv stem cell enhanc osteoarthr treatment osteoarthr oa chronic degen joint diseas remain challeng treatment due lack diseas modifi therapi promis therapeut agent adipos deriv stem cell adsc effect anti inflammatori chondroprotect paracrin effect enhanc genet modif unfortun direct cell deliveri without matrix support often result poor viabil therapeut cell herein hydrogel implant approach enabl intra articular deliveri gene engin adsc develop improv therapeut outcom surgic induc rat oa model inject extracellular matrix ecm mimick hydrogel prepar carrier cell deliveri provid favor microenviron adsc spread prolifer ecm mimick hydrogel could reduc cell death post inject addit adsc genet modifi overexpress transform growth factor tgf one paracrin factor exert anti inflammatori pro anabol effect gene engin adsc overexpress tgf adsc enhanc paracrin effect oa like chondrocyt effect decreas express tumor necrosi factor alpha increas express collagen ii aggrecan surgic induc rat oa model intra articular inject adsc load hydrogel mark reduc cartilag degener joint inflamm loss subchondr bone taken togeth studi provid potenti biomateri strategi enhanc oa treatment deliv gene engin adsc within ecm mimick hydrogel | D020100;D010003 | T047;T122 |
34,671,790 | super assembl silica nanoprob intracellular zn ii sens reperfus injuri treatment situ mof crystal product excess free zinc ion zn cell identifi import caus cell injuri apoptosi ischemia reperfus thus develop nanosystem multipl therapeut function signific elimin multipl cell injuri factor great interest super assembl nanosystem consist polyethylen glycol peg surfac modifi mesopor silica nanoparticl msn encapsul methylimidazol mi zn probe pzn fabric mi p msn nanoassembl show turn fluoresc signal nm toward zinc ion due presenc pzn besid zeolit imidazol framework zif could assembl site intracellular mi chelat free zinc ion experiment result reveal mi p msn exhibit excel biocompat non cytotox abl provid satisfactori protect ogdr treat cell base zinc ion adsorpt antioxid effect zif could effect improv surviv rate reperfus injuri cell notabl select quantit sens zn success carri cell strategi highlight potenti detect absorpt assembl excess zinc ion simultan cell therapi provid promis therapeut method ischem stroke oxid damag diseas associ zinc ion accumul | D015427;D012822 | T037;T197 |
34,671,789 | protect menhaden oil oxid picker emuls base deliveri system lactalbumin chitosan colloid nanoparticl studi lactalbumin chitosan ala chi colloid nanoparticl spontan form main electrostat interact stabil picker emuls load health benefici unstabl menhaden oil oxid stabil menhaden oil suppos signific enhanc picker emuls base deliveri system ala chi colloid particl film ala chi colloid nanoparticl higher surfac hydrophob ala ph near neutral wettabl ala chi nanoparticl observ ph stabl picker emuls menhaden oil fraction ww success fabric ww ala chi nanoparticl picker emuls exhibit superior storag heat centrifug stabil format gel like structur confirm rheolog result viscos storag modulus frequenc rang hz strain exhibit remark increas increas colloid particl concentr oil fraction increas oil fraction ww colloid particl concentr ww pronounc facilit inhibit lipid oxid confirm detect format primari secondari oxid product | D004655;D005395 | T104;T121;T109;T127 |
34,671,787 | thin fluorin polym film microcav array cell cultur label free autom featur extract increas need autom label free morphometr analysi use brightfield microscopi imag cell cultur system requir autom featur detect achiev improv imag contrast eg reduc refract index mismatch light path novel microcav platform fabric use microthermoform thin fluorin ethylen propylen fep film match refract index cell cultur medium provid homogen background signal intens describ fep chemic inert mechan stabl use substrat light sheet microscopi microcav promot format mous embryon stem cell mesc aggreg show axial elong germ layer specif similar embryon develop label free featur extract pipelin base machin learn plugin fiji use extract morphometr featur time laps imag high robust reproduc manner last pipelin util test effect drug latrunculin mesc aggreg highlight platform potenti high content screen hcs drug discoveri new microengin tool import step toward label free imag free float stem cell aggreg pave way high content drug test translat studi | D018929;D005465 | T059;T109 |
34,671,786 | one pot gram scale synthesi virucid heparin mimick polym hsv inhibitor straightforward gram scale synthesi method develop engin high sulfat hyperbranch polyglycerol bear sulfat alkyl chain compound shorter alkyl chain show multival virustat inhibit herp simplex virus type hsv similar heparin contrast compound longest alkyl chain irrevers inhibit virus | D000998;D018259 | T121;T005 |
34,671,784 | innov data process method studi nanoparticl format droplet microfluid use x ray scatter x ray scatter techniqu provid power mean character format nanoparticl solut coupl techniqu segment flow microfluid devic offer well defin environ give access situ time resolv analysi excel reproduc elimin potenti radiat damag howev analysi result dataset extrem time consum compris frame correspond droplet alon continu phase alon interfac describ robust low cost versatil droplet microfluid devic use studi format magnetit nanoparticl simultan synchrotron sax wax later outlet capillari facilit x ray analysi reaction time second minut accommod two step data process method describ exploit uniqu wax signatur droplet continu phase interfaci region identifi frame correspond droplet sort background scatter subtract use autom frame frame approach allow signal nanoparticl isol raw data model data give quantit inform evolut size structur nanoparticl agreement tem observ versatil platform readili employ studi wide rang dynam process heterogen system | D044085;D053758 | T073;T090 |
34,671,677 | cst multitask learn framework colorect cancer region mine base transform colorect cancer high death rate cancer clinic view diagnosi tumour region critic doctor data accumul task take lot time labor larg varianc differ doctor develop comput vision detect segment colorect cancer region ct mri imag seri great challeng past decad still great demand automat diagnosi paper propos novel transfer learn protocol call cst union framework colorect cancer region detect segment task base transform model effect construct cancer region detect segment joint make higher detect accuraci incorpor autoencod base imag level decis approach leverag imag level decis cancer slice also compar framework one stage two stage object detect method result show propos method achiev better result detect segment task propos framework give anoth pathway colorect cancer screen way artifici intellig | D000465;D001185 | T170;T066;T073;T090 |
34,671,589 | multi compon intervent improv pediatr servic deliveri guangzhou background access equit effici pediatr servic critic achiev optim child health studi aim evalu effect multi compon intervent pediatr health system two differ period guangzhou method base world health organ six build block model donabedian structur process outcom framework intervent packag develop increas financi human resouc invest strengthen basic health care strive better qualiti pediatr care multi compon intervent packag conduct guangzhou improv pediatr servic deliveri two stage main outcom indic chang alloc pediatrician pediatr bed pediatr servic effici impact pediatrician child mortal result found pediatrician per children pptc pediatr bed per children pbptc increas respect infant mortal rate imr mortal rate umr drop gini coeffici pptc pbptc decreas respect repres improv pediatr resourc distribut accord servic popul howev equal spatial distribut improv much averag effici pediatr servic fluctuat unit increas pptc associ reduct imr reduct umr conclus find suggest multi compon intervent strategi effect particular reduct child mortal futur rigor multi facet indic integr comprehens evalu intervent | D046688;D007226 | T081 |
34,671,588 | recurr neural network reinforc learn model covid predict detect predict novel coronavirus present new challeng medic research communiti due widespread across globe method driven artifici intellig help predict specif paramet hazard outcom pandem recent deep learn base approach proven novel opportun determin various difficulti predict work two learn algorithm name deep learn reinforc learn develop forecast covid articl construct model use recurr neural network rnn particular modifi long short term memori mlstm model forecast count newli affect individu loss cure follow day studi also suggest deep learn reinforc optim covid predict outcom base symptom real world data util analyz success suggest system find show establish approach promis prognost outcom concern current covid pandem outperform long short term memori lstm model machin learn model logist regres lr term error rate | D001185;D000086382 | T047;T066;T073;T067;T090 |
34,671,587 | famili function loneli emot regul hope secondari vocat school student moder mediat model studi explor famili function key factor loneli hope emot relat secondari vocat school student novel coronavirus pandem chines version olson famili function scale russel loneli scale snyder hope scale gross emot regul scale complet particip guardian type signific predict famili function loneli famili function signific posit correl loneli relationship famili function loneli mediat hope express suppress concurr moder relationship hope loneli studi offer meaning insight famili function chines secondari vocat school student find support moder mediat model exemplifi relationship famili function loneli express suppress hope although result show high hope mediat lower famili function loneli low express suppress led intens loneli immedi studi confirm emot strategi import associ mental health also suggest school pay attent student emot regul help rebuild hope appropri cognit reliev loneli crisi event | D000080103;D013334 | T098;T041;T081 |
34,671,586 | cardiovascular risk awar calcul year risk among femal employe taibah univers cardiovascular diseas cvd common caus death disabl worldwid saudi arabia one middl incom countri proport cvd mortal rate knowledg cvd modifi risk factor vital pre requisit chang health attitud behavior lifestyl practic individu therefor intend assess employe knowledg risk cvd symptom heart attack stroke calcul futur year cvd risk epidemiolog cross section communiti facil base studi conduct women age year employe taibah univers al madinah al munawarah recruit screen self administr questionnair distribut women exclud elig total women met inclus criteria invit next step determin cvd risk factor use step questionnair use surveil non communic diseas risk factor cvd addit anthropometr measur biochem measur done base identifi atherosclerot cardiovascular diseas ascvd risk factor laboratori test result risk calcul use framingham studi cardiovascular diseas year risk assess data analyz use graphpad prism softwar graphpad softwar ca usa result show mean age studi sampl year elev percentag obes rise abdomin circumfer among women hypertens htn consider chronic diseas among particip half sampl ie accord ascvd risk estim studi particip distribut four group low risk borderlin risk intermedi risk high risk comparison categori base cvd year risk estim indic signific variat low risk group intermedi high risk group p p respect multivari analysi detect factor relat cvd risk women intermedi high risk cvd age smoke bodi mass index bmi unhealthi diet blood pressur bp measur famili histori cvd p present studi report limit knowledg awar cvd consid low knowledg conclus present studi among univers sampl madinah report limit knowledg awar cvd risk find support need educ program enhanc awar risk factor prevent cvd | D002318 | T047 |
34,671,569 | microbi world could metagenom next generat sequenc involv acut respiratori failur use metagenom next generat sequenc mngs identifi pathogen investig aim compar power microbi identif mngs various method patient acut respiratori failur | D003924;D009169;D012131 | T007;T047;T046 |
34,671,568 | interact extracellular matrix trigger calcium signal trypanosoma cruzi prior cell invas trypanosoma cruzi etiolog agent chaga diseas human infect wide varieti vertebr trypomastigot parasit infect form invad mammalian cell still poor understood mechan adhes tissu cultur deriv trypomastigot extracellular matrix ecm prior cell invas shown relev part process chang phosphoryl nitrosyl nitrat level protein late phase interact h lead reprogram trypomastigot metabol dna bind profil modifi histon describ group involv calcium signal earli phase parasit interact ecm describ increment intracellular calcium concentr trypomastigot ecm interact depend ca uptak extracellular medium sinc inhibit egta nifedipin inhibitor l type voltag gate ca channel sphingosin depend plasma membran ca channel vanad inhibitor plasma membran ca atpas furthermor nifedipin inhibit invas host cell tissu cultur deriv trypomastigot dose depend manner reach inhibit nifedipin data indic import ca uptak medium parasit ecm interact host cell invas previous treatment ecm proteas abolish ca uptak reinforc possibl event may connect mitochondrion play relev role ca homeostasi trypomastigot interact ecm shown increment intracellular ca concentr presenc antimycin contrast calcium homeostasi disruptor cyclopiazon acid endoplasm reticulum bafilomycin acidocalcisom total phosphatas activ parasit decreas presenc nifedipin egta okada acid impli role calcium phosphoryl level protein interact ecm tissu cultur deriv trypomastigot summari describ increment ca earli phase trypomastigot interact ecm implic nifedipin sensit ca channel influx ca mitochondrion relev organell ca homeostasi data unravel complex sequenc event prior host cell invas | D014355;D014349 | T204;T047 |
34,671,567 | effect electroacupunctur gut microbiota particip knee osteoarthr close relationship knee osteoarthr koa gut microbiota recent describ herein aim investig effect electroacupunctur ea gut microbiota particip koa conduct studi particip koa match healthi control hcs sixti particip alloc either ea group n sham acupunctur sa group n five obligatori acupoint three adjunct acupoint punctur ea group eight non acupoint separ convent acupoint meridian use sa group particip group receiv session within eight week fecal microbi analys ribosom rna gene sequenc carri collect stool week four sampl chang defec habit exclud result show western ontario mcmaster univers osteoarthr index womac total score p nrs score p decreas ea group sa group moreov ea could revers koa relat bacteria includ bacteroid eubacterium halliigroup agathobact r streptococcus number signific differ genera koa patient hcs less ea treatment sa treatment meant ea modifi composit gut microbiom make closer healthi peopl signific affect microbi divers two genera includ agathobact p lachnoclostridium p statist increas baselin ea group pair wilcoxon rank sum test ea treatment bacteroid p abund streptococcus p signific reduc patient demonstr adequ respons inadequ respons wilcoxon rank sum test spearman correl test gut microb koa clinic outcom indic bacteroid agathobact negat correl nrs score womac total score womac pain stiff pain score p streptococcus posit correl p studi suggest ea contribut improv koa gut microbiota could potenti therapeut target | D015670;D015671;D000069196;D020370 | T007;T047;T001;T061 |
34,671,465 | current level coverag iron folic acid fortif insuffici meet recommend intak women reproduct age low middl incom countri food fortif effect intervent improv matern child health folic acid fortif reduc neural tube defect due folat defici iron fortif effect reduc matern anemia due iron defici paper describ method estim current coverag level iron fortif folic acid fortif estim current impact fortif low middl incom countri lmic use live save tool list | D003906;D009436 | T080;T047;T019 |
34,671,464 | zero margin drug polici reduc econom burden stroke patient china china face sever stroke challeng china fulli implement zero margin drug polici zmdp cancel drug markup public hospit base system health account sha paper explor chang econom burden stroke china implement zmdp provid accur refer policymak | D004364;D020521 | T047;T121 |
34,671,463 | analysi sar cov rna surfac new york citi studi sought determin presenc sar cov virus surfac traine faculti academ eye clinic came contact daili life time covid pandem new york citi | D000086382;D012367 | T047;T114;T067 |
34,671,462 | research gap transform tuberculosi data action better health outcom systemat literatur review work end tuberculosi tb epidem lower middl incom countri nation tb program need tool measur monitor strengthen relev capabl creat continu transform data action da improv tb program result howev lack scientif evid determin specif measur dimens da continuum enabl tb program identifi barrier enabl da guid select intervent appropri context decis make capabl various tb program actor | D014376 | T047 |
34,671,450 | evalu angiogenesi patholog classif extrahepat cholangiocarcinoma dynam mr imag e healthcar stage cholangiocarcinoma determin respect mr accur noninvas method provid size tumor vascular patenc inform dynam contrast enhanc magnet reson imag dce mri noninvas inspect method evalu vascular structur function characterist tumor tissu howev limit note technolog present technolog use alon assist method convent mri examin ecc patient admit indira gandhi medic colleg hospit select research subject classifi patholog accord steiner classif system imag process region interest roi select imag measur rate constant kep extravascular space volum fraction tissu volum transfer constant ktran case high differenti carcinoma case moder differenti carcinoma case lowli differenti carcinoma non vegf express note case low express note case moder express note case high express case note relev paramet dynam mri imag quantit reflect angiogenesi patholog classif ecc suggest clinic treatment ecc ktran kep valu ecc patient associ patholog classif signific differ p besid due fact patient complet hold breath air leak reduc imag qualiti | D001650;D018281;D017216 | T058;T191 |
34,671,449 | analysi mechan breast metastasi base imag recognit ultrasound diagnosi breast cancer one cancer highest incid among women late stage cancer cell may metastas distanc caus multipl organ diseas threaten live patient detect lymph node metastasi base patholog imag key indic diagnosi stage breast cancer correct stage decis prerequisit basi target treatment present detect lymph node metastasi main reli manual screen pathologist time consum labor intens diagnosi result variabl subject automat stage method base panoram imag calcul sentinel lymph node breast propos paper provid set standard high accuraci repeat object diagnosi result howev difficult automat detect locat cancer metastasi area high complex panoram imag lymph node paper propos novel deep network train strategi base slide window train automat local model cancer metastasi area train strategi first train initi convolut network small amount data extract fals posit fals negat imag block use manual screen combin automat network screen reclassifi fals posit block improv class negat categori use mammographi ultrasound mri f fdg pet ct examin detect rate diagnost accuraci primari cancer breast patient axillari lymph node metastasi first diagnosi obtain detect rate diagnost accuraci breast mri primari cancer breast much higher x ray ultrasound f fdg pet ct p valu mammographi ultrasound pet ct examin show differ detect rate diagnost accuraci primari cancer breast patient axillari lymph node metastasi first diagnosi breast mri use routin examin patient axillari lymph node metastasi first diagnosi primari breast cancer first diagnos patient axillari lymph node metastasi often present local asymmetr compact calcif x ray often appear small focal mass lesion ductal lesion without three dimension space occupi effect ultrasound | D001943;D000072078 | T191;T060 |
34,671,448 | artifici neural network algorithm evalu postop rehabilit patient order explor applic artifici neural network rehabilit evalu kind ann stabl reliabl artifici intellig algorithm propos learn exist clinic gait data method extract gait characterist paramet patient differ age diseas type cours diseas repeat data iter final simul correspond gait paramet patient experi show train ann score human data cohen kappa strong correl ann improv ashworth score assess human rater r p stabl reliabl artifici intellig algorithm ann provid new idea method clinic rehabilit evalu | D001185;D016571 | T170;T066;T073;T090 |
34,671,447 | clinic effect virtual realiti technolog rehabilit train sport injuri order make patient recov limb function rehabilit train virtual realiti technolog emerg human comput interact technolog use comput correspond applic softwar build virtual realiti environ complet train task virtual environ attract patient conduct repeat train game task base train mode gradual realiz rehabilit train goal rehabilit popul certain exercis abil kinemat human upper limb main analyz virtual realiti system base htc vive develop feasibl work effici upper limb rehabilit train system verifi experi adult volunt healthi need rehabilit train particip experi recruit experiment data record virtual realiti upper limb rehabilit system questionnair extract motion data system applic effect analyz evalu simul diagram follow result rehabilit train show averag score healthi subject point point per question therefor feasibl perform upper limb rehabilit train use htc vive virtual realiti rehabilit system | D001265;D000071939;D000076142 | T061;T066;T037 |
34,671,419 | identif hub gene tuberculosi via bioinformat analysi tuberculosi tb serious chronic bacteri infect caus mycobacterium tuberculosi mtb one deadliest diseas world heavi burden peopl world howev hub gene involv host respons remain larg unclear | D053263 | T044 |
34,671,418 | impt fdnpl identif membran protein type function domain natur languag process approach membran protein import kind protein play essenti role sever cellular process base intramolecular arrang posit cell membran protein divid sever type report type membran protein high relat function determin membran protein type hot topic recent year plenti comput method propos far use function domain inform encod protein howev procedur still crude studi design novel featur extract scheme obtain inform featur protein function domain inform scheme term domain word protein repres domain sentenc natur languag process approach wordvector appli access featur domain refin protein featur base featur random k labelset random forest base classifi employ build multilabel classifi name impt fdnpl tenfold cross valid result indic good perform classifi furthermor classifi superior classifi base featur deriv function domain via one hot scheme deriv properti protein suggest effect protein featur generat propos scheme | D009323 | T066 |
34,671,416 | applic medic imag base deep learn treatment lumbar degen diseas osteoporosi bone cement screw explor applic valu magnet reson spectroscopi mrs gsi energi spectrum electron comput tomographi ct medic imag base deep convolut neural network cnn treatment lumbar degen diseas osteoporosi | D000077321 | T066 |
34,671,415 | emot recognit base eeg use generat adversari net convolut neural network emot recognit play import role field human comput interact hci automat emot recognit base eeg import topic brain comput interfac bci applic current deep learn wide use field eeg emot recognit achiev remark result howev due cost data collect eeg dataset small amount eeg data sampl categori unbalanc dataset problem make difficult deep learn model predict emot state paper propos new sampl generat method use generat adversari network solv problem eeg sampl shortag sampl categori imbal experi explor perform emot recognit frequenc band correl frequenc band separ comput model data augment standard eeg base emot dataset experiment result show method generat adversari network data augment effect improv perform emot recognit base deep learn model find frequenc band correl deep learn model conduc emot recognit | D016571 | T170 |
34,671,395 | sentiment classif financi text base deep learn sentiment classif financi text great import predict stock market financi crise present popular applic field natur languag process nlp adopt deep learn applic automat text classif text base sentiment classif becom extens howev field financi text base sentiment classif due lack label sampl applic limit domain adapt base financi text sentiment classif method propos paper adopt sourc domain sd text data sentiment label larg amount unlabel target domain td financi text data train sampl propos neural network propos method cross domain transfer learn base method domain classif subnetwork ad origin neural network domain classif loss function also ad origin train loss function therefor network simultan adapt target domain accomplish classif task experi propos sentiment classif transfer learn method carri open sourc dataset propos method paper use review amazon book dvds electron kitchen applianc sourc domain cross domain learn classif accuraci rate reach respect compar nontransf learn classif accuraci rate improv respect | D000465;D000077321 | T170;T066 |
34,671,394 | mathemat analysi fraction order predat prey network feedback control strategi paper examin bifurc control problem class delay fraction order predat prey model accord enhanc feedback control first bifurc point devis model precis figur via theoret deriv take time delay bifurc paramet second set compar analysi influenc bifurc control numer studi contain enhanc feedback disloc feedback elimin feedback approach seen stabil perform propos model immens heighten enhanc feedback approach end numer exampl given illustr feasibl theoret result | D011235 | T054 |
34,671,393 | multiscal cluster approach non iid nomin data multiscal bring great benefit peopl observ object problem differ perspect multiscal cluster wide studi various disciplin howev research studi numer dataset lack research cluster nomin dataset especi data nonindepend ident distribut non iid aim current research situat paper propos multiscal cluster framework base non iid nomin data first benchmark scale dataset cluster base coupl metric similar measur second propos transform cluster result benchmark scale target scale two algorithm name upscal base singl chain downscal base lanczo kernel respect final experi perform use five public dataset one real dataset hebei provinc china result show method provid us competit perform also reduc comput cost | D000465 | T170 |
34,671,392 | automat film label acquisit method base improv neural network optim mutat ant coloni algorithm nowaday constant chang public aesthet standard larg number new type theme film program emerg reason paper propos improv neural network optim mutat ant coloni algorithm automat acquisit film label overcom disadvantag tradit neural network difficulti determin weight slow converg speed easi fall local minimum also make shortcom face use ant coloni algorithm alon gradient inform quantum genet algorithm neural network result show user similar judgment ad process calcul user rate deviat movi neighbor choos add movi tag weight rate similar basi neighbor select target movi process predict target movi rate experi show effect algorithm | D009040;D016571 | T170;T073 |
34,671,391 | fuzzi comprehens evalu model synergi base transfer learn graph neural network rapid develop modern china influx capit number compani gradual increas howev compani oper long time due various reason therefor merger acquisit occur larg compani merg small compani extent number employe guarante market stabil howev merger acquisit also higher risk pace merger acquisit acceler case fail merger acquisit synergi effect merger acquisit import indic judg perform merger acquisit articl measur synergi obtain main enterpris perspect perform chang establish evalu model rate chang financi indic migrat learn estim neural network model conduct empir analysi transfer learn neural network studi depth research articl accur assess synergi effect obtain merger acquisit analyz whether compani profit merger acquisit provid refer subsequ merger acquisit compani | D006273 | T058 |
34,671,390 | bayesian classic infer general log logist distribut applic surviv data general log logist distribut especi use model surviv data variabl hazard rate shape extend log logist distribut ad extra paramet classic distribut result greater flexibl analyz model various data type deriv fundament mathemat statist properti propos distribut paper mani well known lifetim special submodel includ propos distribut includ weibul log logist exponenti burr xii distribut maximum likelihood method use estim unknown paramet propos distribut mont carlo simul studi run assess estim perform distribut signific model monoton nonmonoton hazard rate function quit common surviv reliabl data analysi furthermor propos distribut flexibl use demonstr real world data set compar submodel weibul log logist burr xii distribut well three paramet parametr surviv distribut exponenti weibul distribut three paramet log normal distribut three paramet shift log logist distribut three paramet gamma distribut exponenti weibul distribut propos distribut plausibl accord good fit log likelihood inform criterion valu final data set bayesian infer gibb sampl perform use comput approxim bay estim well highest posterior densiti credibl interv converg diagnost techniqu base markov chain mont carlo techniqu use | D001499 | T081 |
34,671,389 | predict geolog paramet tunnel time seri analysi situ data tunnel bore machin tbm type heavi load equip wide use underground tunnel construct geolog condit tunnel process decis factor direct affect control construct equip tbm tunnel alway take place underground acquisit geolog inform becom key issu field studi focus intern relationship sequenti natur tunnel situ data continu interact equip geolog introduc long short term memori lstm time seri neural network method process situ data method predict geolog paramet advanc base tbm real time state monitor data propos propos method appli tunnel project china r predict result five geolog paramet higher perform lstm compar artifici neural network ann predict accuraci lstm signific higher compar ann general robust lstm also better ann indic propos lstm method could extract sequenc properti situ data rule equip geolog interact reflect increas memori structur model introduct gate concept accur predict geolog paramet tunnel realiz addit influenc time window distanc predict model discuss propos method provid new approach toward obtain geolog inform tbm construct also provid certain refer effect analysi situ data sequenc properti | D005844;D016571 | T170;T090 |
34,671,388 | design research mathemat teach intellig classroom base pca nn algorithm increas import mathemat basic educ evalu analyz intellig effect mathemat teach classroom scientif method becom one indic evalu intellig classroom paper studi design applic mathemat teach intellig classroom base pca nn princip compon analysi neural network algorithm first paper briefli describ current research status mathemat teach intellig classroom design pca nn algorithm second combin key factor mathemat teach formul specif standard put forward adapt strategi intellig person intellig mathemat teach classroom final algorithm verifi experi result show student differ mathemat basic level mathemat teach intellig classroom base pca nn algorithm effect improv qualiti mathemat classroom teach research factor teach qualiti effect interact mode involv process mathemat teach classroom design intellig classroom design factor affect teach qualiti determin paper analyz studi system differ angl research result provid help current qualiti evalu classroom teach use pca nn algorithm make quantit analysi multivari verif mathemat classroom teach effect | D000465;D007360 | T170;T041 |
34,671,363 | interact chronic endometr caus endometri microbiota disord endometri immun environ chang recurr implant failur investig interact chronic endometr ce caus endometri microbiota disord endometri immun environ chang recurr implant failur rif | D059467 | T086;T081 |
34,671,359 | molecular cellular mechan modul train immun various cell type respons pathogen encount induct train immun repres emerg concept defin abil innat immun cell acquir memori phenotyp typic hallmark adapt respons key point modul establish train immun includ epigenet metabol function chang differ innat immun non immun cell regard epigenet chang describ long non code rnas lncrnas act molecular scaffold allow assembl chromatin remodel complex catalyz epigenet chang chromatin hand relev metabol chang occur process includ increas glycolyt rate accumul metabolit tricarboxyl acid tca cycl subsequ regul activ histon modifi enzym ultim drive epigenet chang function consequ establish train immun includ enhanc cytokin product increas antigen present augment antimicrobi respons articl discuss current knowledg regard abil differ cell subset acquir train immun phenotyp molecular mechan involv trigger respons knowledg help develop broad spectrum therapi infecti diseas base modul epigenet metabol cue regul develop train immun | D007111 | T040;T043 |
34,671,357 | immunom investig holocyclotoxin produc first protect anti venom vaccin australian paralysi tick ixod holocyclus venom produc anim ubiquit dissemin among vertebr invertebr fish snake scorpion spider tick tick speci worldwid confirm caus paralysi mammalian host australian paralysi tick ixod holocyclus potent paralyz tick speci known indigen three host tick speci secret potent neurotoxin known holocyclotoxin hts holocyclotoxin caus sever harm toxicosi lead rapid flaccid paralysi result death suscept host dog antivenin general polyclon antibodi treatment develop sheep hors camel administ follow bite venom creatur current method prevent treat tick paralysi reli upon chemic acaricid prevent treatment prompt remov tick attach host follow administr commerci tick antiserum tas respect howev method sever drawback poor efficaci non standard dosag advers effect expens administ recent holocyclus tick transcriptom salivari gland viscera report larg famili holocyclotoxin peptid sequenc ident pilot trial demonstr correct fold holocyclotoxin need induc protect paralysi immunogen holocyclotoxin measur use commerci tick antiserum select ht ht ht ht inclus novel cocktail vaccin hts ht ht ht ht ad cocktail vaccin ensur sequenc variat among ht protein famili encompass formul second trial compar cocktail hts placebo group demonstr complet protect tick challeng report first success anti venom vaccin protect dog tick paralysi | D018884 | T204 |
34,671,355 | defin innat immun respons sar cov human macrophag interact host innat immun respons follow sever acut respiratori syndrom coronavirus sar cov infect driver acut respiratori distress syndrom ard amongst inflammatori end organ morbid life threaten coronavirus diseas covid herald virus induc activ mononuclear phagocyt mps monocyt macrophag dendrit cell mps play substanti role aberr immun secretori activ affect profound system inflamm end organ malfunct follow presenc persist viral compon virion without evid viral replic elucid sar cov mp interact investig transcriptom proteom profil human monocyt deriv macrophag express sar cov receptor angiotensin convert enzym parallel monocyt macrophag differenti fail affect product viral infect contrast simpl macrophag viral exposur led robust pro inflammatori cytokin chemokin express attenu type interferon ifn activ parallel dysregul innat immun signal pathway specif link ifn conclud sar cov infect host mount robust innat immun respons character pro inflammatori storm herald end organ tissu damag | D007113 | T032 |
34,671,354 | identif polyval vaccin candid extracellular secretori protein vibrio alginolyticus bacteri infect caus huge loss aquacultur wide rang health issu human vaccin econom effici environ friend agent protect host bacteri infect studi aim identifi broad cross protect antigen extracellular secretori proteom marin bacterium vibrio alginolyticus predict extracellular secretori protein genom random select gene clone construct dna vaccin use immun zebrafish danio rerio innat immun respons gene also investig among dna vaccin protect v alginolyticus infect increas surviv compar control vaccin lower protect effect furthermor also exhibit cross immun protect effect pseudomona fluorescen andor aeromona hydrophila infect mechan cross protect abil explor base conserv epitop innat immun respons antibodi neutral abil result indic potenti polyval vaccin candid bacteri infect addit result suggest extracellular secretori proteom antigen pool use identif cross protect immunogen | D000087506 | T062 |
34,671,352 | associ singl nucleotid polymorph co stimulatori gene within non hla region prognosi leukemia patient hematopoiet stem cell transplant avoid graft reject hematopoiet stem cell match classic human leukocyt antigen hla allel primari choic clinic allogen transplant howev even fulli hla match hematopoiet stem cell use transplant patient still poor prognosi hematopoiet stem cell transplant hsct suggest hla system determin outcom hsct studi investig whether singl nucleotid polymorph snps co stimulatori gene within non hla region relat outcom hsct genom dnas patient acut leukemia receiv hsct respect donor collect analysi thirti four snps locat four co stimulatori gene includ cytotox lymphocyt associ protein ctla cd tumor necrosi factor ligand superfamili tnfsf program cell death protein pdcd select explor relationship advers outcom transplant includ mortal cytomegalovirus infect graft versus host diseas relaps result reveal nine snps ctla gene five snps pdcd gene two snps tnfsf gene four snps cd gene signific associ occurr advers outcom post hsct snps may play import role immun respons allograft post hsct target develop strategi identifi appropri donor | D018380;D020641 | T086;T061 |
34,671,351 | comput infer valid analysi utr leader sequenc allel immunoglobulin heavi chain variabl gene upstream downstream sequenc immunoglobulin gene may affect express gene howev sequenc rare studi character studi immunoglobulin repertoir infer larg rearrang immunoglobulin transcriptom data set offer opportun defin upstream region untransl region leader sequenc establish new data pre process procedur elimin artifact caus race librari generat process reanalyz previous studi data set defin human immunoglobulin heavi chain gene identifi novel upstream region well previous identifi upstream region may identifi error upstream sequenc also identifi set previous uncharacter germlin gene allel sever novel upstream region variant valid instanc segreg singl haplotyp heterozygot subject snps repres sever sequenc variant identifi popul data final base outcom analysi defin set testabl hypothes respect placement particular allel complex ighv locus haplotyp discuss evolutionari related particular heavi chain variabl gene base sequenc upstream region | D020121;D019295;D020869;D059014;D007143;D007135 | T116;T123;T129;T091;T114;T059;T063 |
34,671,349 | cgat cell graph attent network grade pancreat diseas histolog imag earli detect pancreat ductal adenocarcinoma pdac one aggress malign pancrea crucial avoid metastat spread bodi region detect pancreat cancer typic carri assess distribut arrang tumor immun cell histolog imag complic due morpholog similar chronic pancreat cp co occurr precursor lesion tissu current autom method grade pancreat cancer reli extens featur engin involv accur identif cell featur utilis singl number spatial inform indic grade purpos moreov sophist method involv black box approach neural network offer insight model abil accur identifi correct diseas grade paper develop novel cell graph base cell graph attent cgat network precis classif pancreat cancer precursor multiplex immunofluoresc histolog imag six differ type pancreat diseas issu class imbal address bootstrap multipl cgat net self attent mechan facilit visual cell cell featur like respons predict capabl model also shown model signific outperform decis tree classifi built use spatial inform metric morisita horn mh indic | D008962 | T062;T170 |
34,671,346 | integr proteotranscriptom human myometrium labor landscap reveal increas molecular associ inflamm hypoxia stress labor varieti coordin physiolog biochem event caus myometrium transit quiescent contractil state molecular mechan respons transit howev remain unclear better understand transit molecular level global transcriptom proteom human myometri sampl labor labor investig rna sequenc rna seq quantit liquid chromatographi tandem mass spectrometri lc msms via data independ acquisit dia parallel reaction monitor prm method furthermor integr proteotranscriptom analysi perform explor biolog process pathway alter labor analysi identifi differenti express mrnas upregul downregul differenti express protein upregul downregul myometrium nonlabor labor group comprehens result analys show upregul mrnas protein increas inflamm hypoxia stress myometrium labor relat protein cytokin valid prm luminex assay studi confirm biolog process inflamm hypoxia labor myometrium transcriptom proteom level provid recours discov new molecular biolog chang labor | D059467 | T086;T081 |
34,671,342 | modul complement system neoplast diseas central nervous system complement system high conserv compon innat immun involv recogn respond pathogen system serv bridg innat adapt immun modul complement system affect entir host immun respons foreign insult neoplast diseas shown engag complement system order evad immun system gain select growth advantag co opt surround environ tumor prolifer histor central nervous system consid immun privileg environ clear activ role innat adapt immun within central nervous system much research role immunolog modul neoplast diseas within central nervous system focus adapt immun even though innat immun still play critic role natur histori central nervous system neoplasm review modul complement system varieti neoplast diseas central nervous system also discuss gap current bodi knowledg comment futur direct investig | D015213 | T040;T022;T023 |
34,671,317 | associ estrogen receptor gene polymorph polycyst ovari syndrom systemat review meta analysi base observ studi controversi result exist amount studi investig authent associ estrogen receptor gene esr esr polymorph occurr progress polycyst ovari syndrom pcos inconsist might result differ loci sampl size ethnic find potenti correl esresr polymorph pcos risk conduct first systemat review meta analysi comprehens summar current studi larg combin popul | D020022;D020641 | T086;T032 |
34,671,316 | associ age diagnosi type diabet cardiovascular diseas nationwid popul base cohort studi nationwid studi focus impact earli onset type diabet obes develop cardiovascular diseas cvd limit china aim investig associ age diagnosi type diabet risk cvd examin modifi effect obes associ among chines adult | D015992 | T201 |
34,671,229 | magnet reson imag imag segment edg detect intellig algorithm diagnosi surgic wrist joint injuri wrist joint injuri refer injuri wrist joint caus excess stretch ligament joint capsul around joint caus indirect violenc tissu structur wrist joint complex clinic diagnosi effect poor | D007091;D008279 | T170;T066;T059;T060 |
34,671,228 | magnet reson imag featur deep learn algorithm evalu cerebr protect craniotomi evacu hematoma propofol anesthesia studi aim explor valu magnet reson imag mri featur base deep learn super resolut algorithm evalu valu propofol anesthesia brain protect patient undergo craniotomi evacu hematoma optim super resolut algorithm obtain multiscal network reconstruct model base tradit algorithm total patient undergo craniotomi evacu hematoma recruit roll sevofluran control group propofol experiment group evalu use diffus tensor imag dti imag base deep learn super resolut algorithm result show fraction anisotrop imag fa valu hind limb corticospin tract affect side intern capsul experiment group oper nation institut health stroke scale nihss score oxygen satur jugular venous sjvo respect cerebr oxygen uptak rate co er respect differ jugular venous oxygen da jvo mldl mldl mldl respect neuron specif enolas nse central nerv specif protein level ngml ngml respect term number postop complic patient experiment group better control group sevofluran anesthesia differ substanti p conclus mri imag base deep learn super resolut algorithm great clinic valu evalu degre brain injuri patient anesthet propofol protect effect propofol brain nerv | D008279 | T170;T059;T060 |
34,671,227 | ethnotherapeut use phytochem composit physali peruviana l overview plant deriv medicin widespread continu increas tradit modern medicin especi develop countri physali peruviana l among use plant convent medic worldwid review aim highlight ethnotherapeut use phytochem status identifi compound p peruviana | D032321 | T002;T168 |
34,671,226 | predict role neutrophil lymphocyt ratio nlr mean platelet volum lymphocyt ratio mpvlr cardiovascular event adult patient acut heart failur inflammatori respons play potenti role pathogenesi advers outcom heart failur hf aim explor predict role baselin neutrophil lymphocyt ratio nlr mean platelet volum lymphocyt ratio mpvlr cardiovascular event cves patient hospit acut hf | D008214;D063847;D009504 | T025;T059 |
34,671,220 | hippo pathway renew insight craniofaci diseas hard tissu remodel hippo pathway play import role mani pathophysiolog process includ cell prolifer differenti cell death cell migrat invas extens function hippo pathway close relat growth develop also mani diseas includ inflamm cancer studi role hippo pathway craniofaci diseas hard tissu remodel review attempt find new research direct | D000090683 | T043 |
34,671,219 | post translat modif pcna control dna synthesi dna damag toler implic carcinogenesi faith dna replic critic event cell surviv inherit howev exogen endogen sourc damag challeng accur synthesi dna caus dna lesion dna lesion obstacl replic fork progress howev prolong replic fork stall lead replic fork collaps may caus dna doubl strand break dsb order maintain genom stabil eukaryot cell evolv transles synthesi tls templat switch ts resolv replic stall prolifer cell nuclear antigen pcna trimer act slide clamp encircl dna orchestr dna synthesi dna damag toler ddt post translat modif ptms pcna regul function ensur appropri initi termin replic ddt aberr regul pcna ptms result dsb caus mutagenesi poor respons chemotherapi review role pcna ptms dna duplic ddt propos clarifi regul pcna ptms may provid insight understand develop cancer | D063646;D004249;D004261;D011499 | T049;T044;T191;T045 |
34,671,214 | imbal pgd dps pathway involv type diabet brain injuri regul autophagi prostaglandin pgd abund prostaglandin brain involv brain damag caus type diabet td report present studi found increas pgd content relat inhibit autophagi aggrav brain damag td may involv imbalanc express correspond pgd receptor dp dp demonstr dp inhibit autophagi promotedtd induc brain damag activ pikaktmtor pathway wherea dpenhanc autophagi amelioratedtd brain damag activ camppka pathway td rat model dp express decreas dp express increas therefor imbal pgd dps may involv td brain damag regul autophagi howev report whether pka direct inhibit mtor pka catalyt subunit pka c three subtyp express brain subsequ suggest pka could direct interact mtor pka c pka c result suggest imbal pgd dps relat chang autophagi level td brain damag pgd involv td brain damag promot autophagi via dp pkamtor inhibit autophagi via dp pikaktmtor | D001343 | T043 |
34,671,210 | lrp genotyp affect individu suscept nonalcohol fatti liver diseas silibinin therapeut respons via wnt catenin cype signal background nonalcohol fatti liver diseas nafld serious threat human health worldwid high genet suscept rs function germlin variant lrp recent found associ nafld risk studi aim clarifi under mechan associ rs risk impact pharmacotherapi treatment nafld method venous blood sampl collect nafld non nafld patient snp genotyp use mass spectrometri lrp floxdel mous lrp generat model partial function associ human rs liver injuri therapeut effect silibinin compar lrp lrp mice receiv methionin cholin defici mcd diet normal diet effect lrp function alter wnt catenin cype signal activ evalu seri cellular molecular assay result allel lrp rs confirm associ higher risk nafld human subject carrier rs reduc level ast alt compar noncarri lrp mice exhibit less sever liver injuri induc mcd reduc respons treatment silibinin comparison lrp mice suggest lrp target silibinin wnt catenin cype signal togeth ros generat could exacerb overexpress lrp decreas respons lrp sirna silibinin treatment nafld model conclus lrp function affect individu suscept nafld therapeut effect silibinin wnt catenin cype signal pathway present work provid under mechan human individu suscept nafld associ lrp polymorph well rational effect use silibinin nafld patient | D020022 | T032 |
34,671,209 | role mismatch repair age common featur age accumul genet damag throughout life dna damag lead genom instabl mani diseas associ prematur age result increas accumul dna damag order minim damag organ evolv complex network dna repair mechan includ mismatch repair mmr review detail effect mmr genom instabl role age emphas associ mmr hallmark age serv drive amplifi mechan hallmark includ telomer attrit epigenet alter mitochondri dysfunct alter nutrient sens cell senesc close relationship mmr marker may provid prevent treatment strategi reduc incid age relat diseas promot healthi age human be | D020137 | T049 |
34,671,208 | delet smad protect c reactiv protein induc renal fibrosi inflamm obstruct nephropathi introduct aim elev plasma level c reactiv protein crp close associ progress renal injuri patient chronic kidney diseas ckd test hypothesi crp may promot renal fibrosi inflamm via tgf smad depend mechan method role mechan tgf smad crp induc renal fibrosi inflamm examin mous model unilater ureter obstruct uuo induc crp tgsmad ko mice rat tubular epitheli cell line smad gene stabli knock skd nrke result found mice overexpress human crp gene larg promot renal inflamm fibrosi evidenc increas il tnf mcp express f macrophag infiltr mark accumul smooth muscl actin sma collagen fibronectin uuo kidney blunt smad gene delet crptg smadko mechanist found protect renal inflamm fibrosi uuo kidney crptg smadko mice associ inactiv cd nf b tgf smad signal conclus conclus smad defici protect crp mediat renal inflamm fibrosi uuo kidney inactiv cd nf b tgf smad signal | D017353 | T045 |
34,671,206 | intravir protein protein interact sar cov reveal key role n protein virus like particl assembl intravir protein protein interact ppis sar cov host cell may provid use inform deep understand virolog sar cov studi interact structur accessori protein sar cov identifi biomolecular fluoresc complement bifc assay nucleocapsid n protein found interact among structur accessori protein sar cov also specif interact putat packag signal ps sar cov also demonstr ps core contain ps rna bear function ps import assembl viral rna virus like particl vlps packag sar cov rna n depend | D019065 | T038 |
34,671,205 | regul melk ef promot prolifer cervic cancer cell cervic cancer common gynecolog cancer frequent caus death studi investig role melk matern embryon leucin zipper kinas cervic cancer found hpv ee promot melk express activ ef melk knockdown block cancer cell growth furthermor use melk inhibit kinas activ melk caus gm phase arrest cancer cell treatment inhibitor hela cell form multipolar spindl eventu underw apoptosi also found melk involv protein translat fold cell divis melk interactom tempor proteom analysi inhibit melk altogeth result suggest melk may play vital role cancer cell prolifer indic potenti therapeut target cervic cancer | D049109;D015854 | T043;T044 |
34,671,202 | immunotherapi colorect cancer current achiev futur perspect follow dramat success mani type advanc solid tumor interest immunotherapi treatment colorect cancer crc increas grow given compel long term durabl remiss two program cell death pd block antibodi pembrolizumab nivolumab without ipilimumab approv treatment patient metastat colorect cancer mcrc mismatch repair defici microsatellit instabl high dmmr msi h practic chang result sever random control trial move immunotherapi first line treatment msi h metastasi cancer earlier stage report success past year besid new intrigu advanc expand efficaci immunotherapi mcrc mismatch repair profici low microsatellit instabl pmmr msi l demonstr potenti benefit vast major mcrc case great attent also paid advanc cancer vaccin adopt cell therapi act review summar progress also highlight current predict biomark respons immunotherapi broad clinic util | D007167 | T061 |
34,671,200 | comprehens landscap renin angiotensin system pan cancer potenti downstream mediat mechan sar cov background sar cov caus worldwid covid pandem util mechan bind ace crucial compon renin angiotensin system ras subsequ mediat secondari imbal ras famili lead sever injuri host howev studi conduct reveal mechan behind effect sar cov tumor method demograph data extract cancer type sampl employ determin comprehens landscap ras express distribut pretranscript posttranscript regul posttransl modif ptms well genom alter dna methyl modif analyz tissu cell line clinic phenotyp prognost valu signific ras immun infiltr identifi result low express agtr common tumor compar normal tissu low express agtr mas detect tissu cell line differenti express pattern ace ovarian serous cystadenocarcinoma ov kidney renal clear cell carcinoma kirc correl ubiquitin modif involv e ligas genom alter ras famili infrequ across tcga pan cancer program ace highest alter frequenc compar member low express agtr may result hypermethyl promot downregul ras famili link higher clinic stage wors surviv measur diseas specif surviv dss overal surviv os progress free interv pfi especi ace agtr kirc ace agtr classic axi ras famili relat immun infiltr posit correl type macrophag cancer associ fibroblast caf immun checkpoint gene cancer conclus ace ace agt agtr differenti express type cancer ptm ras famili found reli ubiquitin ace agtr might serv independ prognost factor lgg kirc sar cov might modifi tumor microenviron regul ras famili thus affect biolog process cancer | D012084 | T022 |
34,671,196 | melatonin hyperbar oxygen therapi suppress colorect carcinogenesi pleiotrop effect multifacet mechan colorect cancer crc third common cancer worldwid colorect carcinogenesi frequent induc hypoxia trigger reprogram cellular metabol gain malign phenotyp previous hyperbar oxygen hbo therapi melatonin report alter hypox microenviron result inhibit cancer cell surviv accord studi test hypothesi whether hbo melatonin effect inhibit crc carcinogenesi vitro result indic melatonin therapi signific suppress malign phenotyp includ coloni format growth invas migrat cancer stem dose depend manner crc cell line multifacet mechan similar vitro studi vivo find demonstr melatonin hbo combin treatment effect promot apoptosi cleav caspas cleav parp arrest tumor prolifer follow inhibit colorect tumorigenesi crc xenograft tumor model moreov melatonin hbo combin treatment modul multifacet mechan includ decreas hif express allevi akt activ repress glycolyt metabol hk pfkpkmldh restrain cancer stem pathway tgf p smadoctnanog reduc inflamm p nfb cox diminish immun escap pd l revers express epitheli mesenchym transit e cadherinn cadherinmmp conclus melatonin hbo therapi suppress colorect carcinogenesi pleiotrop effect multifacet mechan suggest melatonin hbo treatment could novel therapeut strategi crc treatment | D006931 | T061 |
34,671,195 | gene presenceabs variat analysi coronavirus famili display pan genom divers sar cov belong coronavirus famili compar genom featur viral genom coronavirus famili improv understand sar cov present first pan genom analysi whole genom speci genera coronavirus famili found total gene pan genom coronavirus famili among gene gene gene n gene high conserv also construct pan genom whole genom sar cov gene total sar cov pan genom gene core gene sar cov pan genom coronavirus show lower level divers pan genom rna virus contain core gene three high conserv gene coronavirus famili also core gene sar cov pan genom could potenti target develop nucleic acid diagnost reagent decreas possibl cross reaction coronavirus speci | D016679;D010802 | T062;T028;T078 |
34,671,177 | feasibl laparoscop transabdomin preperiton hernioplasti incarcer inguin hernia incarcer inguin hernia incih defin irreduc inguin hernia problem caus long term incarcer adhes incarcer organ hernial sac difficulti reduct edemat incarcer organ present studi perform evalu feasibl laparoscop transabdomin preperiton tapp hernioplasti treat chronic incih | D006552;D010535 | T190;T061;T047;T060 |
34,671,176 | firefli system organ transillumin robot gynecolog surgeri near infrar fluoresc nirf firefli system becom use widespread techniqu visual detect tumor sentinel lymphnod vascularanatom structur | D010535;D065287 | T061;T060 |
34,671,175 | evalu morbid routin cystoscopi perform intraop total laparoscop hysterectomi primari object determin rate morbid event urinari tract infect hematuria urinari retent fals posit incident find associ routin cystoscopi perform intraop total laparoscop hysterectomi tlh secondari object determin rate urinari complic tlhs center determin detect rate urinari complic use cystoscopi tlhs | D003558;D010535 | T061;T060 |
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