PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,671,170 | cardiac sarcoidosi diagnosi treatment sarcoidosi system granulomat diseas unknown caus clinic present heterogen virtual organ system affect common lung manifest cardiac sarcoidosi cs heterogen depend extent locat diseas rang asymptomat form life threaten arrhythmia well progress heart failur cardiac involv associ wors prognosi diagnosi cs often challeng requir multimod approach base current intern recommend pharmacolog treatment cs base administr anti inflammatori therapi main corticosteroid often combin heart failur medic andor antiarrhythm nonpharmacolog therapeut approach cs cover pacemak defibril implant cathet ablat heart transplant review aim summar current understand cs includ epidemiolog etiopathogenesi clinic present diagnost approach therapeut possibl | D009202;D006333;D009205;D010138;D012507 | T074;T047;T046 |
34,671,168 | evid european presenc america ad transatlant explor took place centuri cross columbus physic evid earli european presenc america found newfoundland canada howev thus far possibl determin activ took place provid evid vike present newfoundland ad overcom imprecis previous age estim make use cosmic ray induc upsurg atmospher radiocarbon concentr ad ref new date lay marker european cognis america repres first known point human encircl globe also provid definit tie point futur research initi consequ transatlant activ transfer knowledg potenti exchang genet inform biota patholog | D054242 | T098 |
34,671,165 | eccdna apoptot product high innat immunostimulatori activ extrachromosom circular dna element eccdna describ literatur sever decad known broad exist across differ speci howev biogenesi function larg unknown develop new circular dna enrich method purifi sequenc full length eccdna nanopor sequenc found eccdna map across entir genom close random manner suggest biogenesi mechan random ligat genom dna fragment consist idea found apoptosi induc increas eccdna generat depend apoptot dna fragment follow ligat dna ligas import demonstr eccdna function potent innat immunostimul manner independ eccdna sequenc depend eccdna circular cytosol dna sensor sting collect studi reveal origin biogenesi immunostimul function eccdna also uncov sens pathway potenti clinic implic immun respons | D017209;D053938;D007113 | T049;T044;T116;T123;T043;T032 |
34,671,164 | shigella evad pyroptosi arginin adp riboxan caspas mous caspas human caspas caspas recogn cytosol lipopolysaccharid lps induc pyroptosi cleav pore form protein gsdmd non canon inflammasom defend gram negat bacteria shigella flexneri caus bacillari dysenteri live freeli within host cytosol caspas resid howev role caspas mediat pyroptosi flexneri infect unknown show caspas protect mice flexneri infect contrast infect anoth cytosol bacterium burkholderia thailandensi flexneri evad pyroptosi mediat caspas caspas hereaft refer caspas use type iii secret system tss effector ospc ospc paralogu ospc coval modifi caspas although use nad donor modif adp ribosyl biochem dissect uncov adp riboxan modif arg arg caspas caspas respect enzymat activ share ospc whose ankyrin repeat domain unlik ospc could recogn caspas adp riboxan arginin block autoprocess caspas well recognit cleavag gsdmd adp riboxan caspas paralys pyroptosi mediat defenc shigella infect mice mutat ospc stimul caspas gsdmd depend anti shigella humor immun generat vaccin like protect effect studi establish adp riboxan arginin bacteri virul mechan prevent lps induc pyroptosi | D057131;D000069292 | T040;T043 |
34,671,163 | low glycaem diet alter lipid metabol influenc tumour growth dietari intervent chang metabolit level tumour microenviron might affect cancer cell metabol alter tumour growth although calor restrict cr ketogen diet kd often thought limit tumour progress lower blood glucos insulin level found cr inhibit growth select tumour allograft mice suggest mechan contribut tumour growth inhibit chang nutrient avail observ cr kd lower lipid level plasma tumour upregul stearoyl coa desaturas scd synthesis monounsatur fatti acid requir cancer cell prolifer lipid deplet environ cr also impair tumour scd activ caus imbal unsatur satur fatti acid slow tumour growth enforc cancer cell scd express rais circul lipid level higher fat cr diet confer resist effect cr contrast although kd also impair tumour scd activ kd driven increas lipid avail maintain unsatur satur fatti acid ratio tumour chang kd fat composit increas tumour satur fatti acid level cooper decreas tumour scd activ slow tumour growth data suggest diet induc mismatch tumour fatti acid desatur activ avail specif fatti acid speci determin whether low glycaem diet impair tumour growth | D050528;D050356 | T044;T061 |
34,671,162 | origin spread domest hors western eurasian stepp domest hors fundament transform long rang mobil warfar howev modern domest breed descend earliest domest hors lineag associ archaeolog evid bridl milk corral botai central asia around bc longstand candid region hors domest iberia anatolia also recent challeng thus genet geograph tempor origin modern domest hors remain unknown pinpoint western eurasian stepp especi lower volga region homeland modern domest hors furthermor map popul chang accompani domest ancient hors genom reveal modern domest hors ultim replac almost local popul expand rapid across eurasia bc synchron equestrian materi cultur includ sintashta spoke wheel chariot find equestrian involv strong select critic locomotor behaviour adapt gsdmc zfpm gene result reject common held associ horseback ride massiv expans yamnaya stepp pastoralist europ around bc drive spread indo european languag contrast scenario asia indo iranian languag chariot hors spread togeth follow earli second millennium bc sintashta cultur | D000071278;D005828;D006736 | T015;T090;T078 |
34,671,161 | late quaternari dynam arctic biota ancient environment genom last glacial interglaci cycl arctic biota experienc substanti climat chang yet natur extent rate respons fulli understood report larg scale environment dna metagenom studi ancient plant mammal communiti analys permafrost lake sediment sampl across arctic span past year furthermor present contemporari plant genom assembl generat refer sequenc studi provid sever insight long term dynam arctic biota circumpolar region scale key find includ relat homogen stepp tundra flora domin arctic last glacial maximum follow region diverg veget holocen epoch certain graze anim consist co occur space time human appear minor factor drive anim distribut higher effect precipit well increas proport wetland plant show negat effect anim divers persist stepp tundra veget northern siberia enabl late surviv sever extinct megafauna speci includ woolli mammoth thousand year ago ka woolli rhinocero ka phylogenet analysi mammoth environment dna reveal previous unsampl mitochondri lineag find highlight power ancient environment metagenom analys advanc understand popul histori long term ecolog dynam | D058448;D056186 | T091;T070;T080 |
34,671,160 | ethic dna research human remain five global applic guidelin group archaeologist anthropologist curat geneticist repres divers global communiti countri us met virtual workshop dedic ethic ancient dna research held novemb widespread agreement global applic ethic guidelin need recent recommend ground discuss research human remain north america alway generaliz worldwid propos follow global applic guidelin take consider divers context hold research must ensur regul follow place work human remain deriv research must prepar detail plan prior begin studi research must minim damag human remain research must ensur data made avail follow public allow critic examin scientif find research must engag stakehold begin studi ensur respect sensit stakehold perspect commit adher guidelin expect promot high ethic standard dna research human remain go forward | D002102;D017408;D038622 | T064;T170;T017;T067;T078 |
34,671,159 | regul intestin immun tissu repair enter glia tissu mainten repair depend integr activ multipl cell type wherea contribut epitheli immun stromal cell intestin tissu integr well understood role intrins neuroglia network remain larg unknown uncov import role enter glial cell egc intestin homeostasi immun tissu repair demonstr infect mice heligmosomoid polygyrus lead enter gliosi upregul interferon gamma ifn gene signatur ifn depend gene modul also induc egc patient inflammatori bowel diseas singl cell transcriptom analysi tunica musculari show glia specif abrog ifn signal lead tissu wide activ pro inflammatori transcript program furthermor disrupt ifn egc signal axi enhanc inflammatori granulomat respons tunica musculari helminth mechanist show upregul cxcl earli immedi respons egc ifn signal provid evid chemokin downstream amplif ifn signal tunica musculari requir measur inflammatori respons helminth resolut granulomat patholog studi demonstr ifn signal enter glia central intestin homeostasi reveal critic role ifn egc cxcl axi immun respons tissu repair infecti challeng | D006706;D012038 | T042;T038 |
34,671,158 | kdmb promot immun evas recruit setdb silenc retroel tumour use various strategi evad immun surveil immunotherapi target tumour immun evas immun checkpoint blockad shown consider efficaci multipl cancer ineffect patient due primari acquir resist recent studi show epigenet regul suppress anti tumour immun suggest epigenet therapi could boost anti tumour immun respons overcom resist current immunotherapi show mous melanoma model deplet kdmb hk demethylas critic melanoma mainten drug resist induc robust adapt immun respons enhanc respons immun checkpoint blockad mechanist kdmb recruit hk methyltransferas setdb repress endogen retroel mmvl demethylas independ manner derepress retroel activ cytosol rna sens dna sens pathway subsequ type interferon respons lead tumour reject induct immun memori result demonstr kdmb suppress anti tumour immun epigenet silenc retroel therefor reveal role kdmb heterochromatin regul immun evas melanoma open new path develop kdmb target setdb target therapi enhanc tumour immunogen overcom immunotherapi resist | D020868;D018626;D019139 | T046;T114;T045;T123 |
34,671,138 | pliocen decoupl equatori pacif temperatur ph gradient ocean dynam equatori pacif drive tropic climat pattern affect marin terrestri ecosystem worldwid region respond global warm profound implic global climat econom stabil ecosystem health result numer studi investig equatori pacif dynam pliocen million year ago late miocen around million year ago analogu futur behaviour region global warm palaeoceanograph record time present appar paradox proxi evid reduc east west sea surfac temperatur gradient along equatori pacif indic reduc wind driven upwel conflict evid enhanc biolog product east pacif typic result stronger upwel reconcil observ provid new evid radic differ modern circul regim earli pliocenel miocen result older acid nutrient rich water reach equatori pacif result provid mechan enhanc product earli pliocenel miocen east pacif even presenc weaker wind driven upwel find shed new light equatori pacif dynam help constrain potenti chang undergo near futur given earth expect reach pliocen like level warm next centuri | D017753;D013696 | T070;T082;T081 |
34,671,130 | prognost role tumour infiltr lymphocyt macrophag relat msi cdx braf status popul base studi metastat colorect cancer patient tumour infiltr cd cd lymphocyt cd macrophag associ favour prognosi localis colorect cancer effect metastat colorect cancer mcrc establish | D053842 | T049 |
34,671,129 | identifi causal genet correl prioriti pathway larg scale complex exposur breast ovarian cancer genet correl causal pathway larg scale complex exposur ovarian breast cancer need systemat explor | D015984 | T169;T079;T078 |
34,671,128 | menopaus hormon therapi risk oesophag adenocarcinoma popul base cohort studi oesophag adenocarcinoma characteris strong male predomin aim test hypothesi menopaus hormon therapi decreas risk oesophag adenocarcinoma | D008593 | T039 |
34,671,127 | express function long non code rna neat isoform breast cancer neat high abund nuclear architectur long non code rna two overlap neat isoform neat neat latter essenti scaffold assembl class nuclear ribonucleoprotein bodi call paraspeckl paraspeckl format elev wide varieti cellular stressor certain development process either transcript upregul neat gene switch neat neat isoform product condit paraspeckl modul cellular process sequest protein rna molecul neat abnorm express mani cancer grow bodi evid suggest mani case high neat level associ therapi resist poor clinic outcom review current knowledg neat express function breast cancer highlight establish role postnat mammari gland develop discuss possibl isoform specif role neat neat differ breast cancer subtyp critic need consid studi neat breast cancer | D017398 | T114;T045;T123 |
34,671,122 | type interferonopathi year brutal demonstr covid pandem effect immun system essenti surviv develop evolutionari time viral nucleic acid detect central pillar defens armamentarium use combat foreign microbi invas ensur cellular homeostasi strategi necessit effici discrimin pathogen deriv dna rna host suggest upregul type interferon signal might serv defin featur novel set mendelian inborn error immun antivir sensor trigger host nucleic acid due failur self versus non self discrimin rare disord play surpris signific role inform understand innat immun relev type interferon signal human health diseas consid learn time field may develop futur | D000086382;D007370;D009696 | T116;T047;T121;T123;T129;T114;T067 |
34,671,121 | outcom adult lymphoma treat nonmyeloabl tli atg radiat boost high risk residu diseas allogen hematopoiet cell transplant evalu impact surviv antithymocyt globulin condit tli atg radiat rt boost high risk residu diseas allogen hematopoiet cell transplant allo hct adult lymphoma exclud mycosi fungoid low grade nhl sllcll evalu patient receiv rt boost within month allo hct institut time tli atg patient receiv boost vs boost lower rate cr vs p higher rate bulki diseas vs p extranod diseas vs p posit pet vs p boost group median rang largest axial lesion diamet cm median follow month rang signific differ os time recurr time graft failur vs without boost trend toward higher percent donor cd chimer seen vs without boost p worst boost relat toxic grade dermat rt boost may help success mitig risk high risk clinic evid residu diseas adult lymphoma undergo allo hct | D006086;D018380;D008223 | T191;T047;T061 |
34,671,120 | distinct clinico biolog featur aml patient low allel ratio flt itd role allogen stem cell transplant first remiss mutant burden flt itd modul prognost impact patient acut myeloid leukemia aml howev patient low allel ratio ar flt itd flt itd low ar clinic featur well genom transcriptom profil remain unclear evid support allogen hematopoiet stem cell transplant allo hsct first complet remiss cr remain controversi studi aim elucid genom featur prognosi transplant outcom flt itd iow aml patient intermedi risk cytogenet flt itd low associ negat enrich leukem stem cell signatur mark enrich ras pathway higher frequenc ras pathway mutat differ flt itd high concurr cebpa doubl mutat favor prognost factor wherea mll ptd mutat splice factor unfavor prognost factor flt itd low patient patient flt itd low shorter overal surviv os event free surviv ef flt wt allo hsct cr associ signific longer os ef compar postremiss chemotherapi patient flt itd low conclus flt itd low associ differ mutat transcriptom profil compar flt itd high presenc concomit poor risk mutat exert negat prognost impact patient flt itd low mark benefit allo hsct cr | D018380;D015470 | T191;T061 |
34,671,117 | overcom tgf mediat immun evas cancer transform growth factor tgf signal control multipl cell fate decis develop tissu homeostasi henc dysregul pathway drive sever diseas includ cancer discuss influenc tgf exert composit behaviour differ cell popul present tumour immun microenviron context depend function cytokin suppress promot cancer homeostasi tgf control inflammatori respons trigger exposur outsid milieu barrier tissu lack tgf exacerb inflamm lead tissu damag cellular transform contrast tumour progress leverag tgf drive unrestrain wound heal programm cancer associ fibroblast well suppress adapt immun system innat immun system conson key role reprogram tumour microenviron emerg data demonstr tgf inhibitori therapi restor cancer immun inde approach synerg immunotherapi includ immun checkpoint blockad unleash robust antitumour immun respons preclin cancer model despit initi challeng clinic translat find spark develop multipl therapeut strategi inhibit tgf pathway mani current clinic evalu | D009369;D016212 | T191;T116;T123 |
34,671,116 | irgitacon metabol pathway crucial determin dendrit cell immun prime function contribut resolut allergen induc airway inflamm itacon produc mitochondri tca cycl enzym aconitas decarboxylas encod immun respons gene irg exert immunomodulatori function myeloid cell howev role irgitacon pathway dendrit cell dc mediat airway inflamm adapt immun inhal allergen primari antigen present cell allerg asthma remain larg unknown hous dust mite hdm challeng irg mice display increas eosinophil airway inflamm mucous cell metaplasia th cytokin product mechan involv impair mite antigen present dc adopt transfer hdm puls dc irg defici mice nave wt mice induc similar phenotyp elev type airway inflamm allerg sensit untarget metabolit analysi hdm puls dc reveal itacon one abund polar metabolit potenti suppress mitochondri oxid damag furthermor immunomodulatori effect itacon translat vivo intranas administr octyl itacon oi follow antigen prime attenu manifest hdm induc airway diseas th immun respons taken togeth data demonstr first time direct regulatori role irgitacon pathway dc develop type airway inflamm suggest possibl therapeut target modul allerg asthma | D000485;D003713;D006836;D013386 | T116;T109;T025;T129;T126 |
34,671,115 | tissu resid memori cell respiratori tract owe capac rapid spread across popul airborn pathogen repres signific risk global health inde sever past major global pandem instig respiratori pathogen greater understand immun cell task protect airway infect allow develop strategi curb spread impact airborn diseas specif subset memori cell resid upper lower respiratori tract term tissu resid memori trm shown play instrument role local immun respons wide breadth viral bacteri infect review discuss factor influenc respiratori tract trm develop longev immun surveil explor vaccin regim har cell approach repres excit new strategi may util tackl next global pandem | D007156;D000091246 | T025;T042 |
34,671,112 | nine gene pharmacogenom profil servic mayo clinic experi pharmacogenom pgx profil servic proof concept project implement pgx patient care mayo clinic | D000071185 | T059 |
34,671,110 | baicalein amelior ulcer coliti improv intestin epitheli barrier via ahril pathway ilc ulcer coliti uc chronic inflammatori diseas gastrointestin tract close relat gut barrier dysfunct emerg evid show interleukin il deriv group innat lymphoid cell ilc confer benefit intestin barrier il express control aryl hydrocarbon receptor ahr previous studi show baicalein protect colon inflammatori damag studi elucid molecular mechan under protect effect baicalein intestin barrier function coliti mice mice administ baicalein mgkg ig day mice freeli drank dextran sulfat sodium dss induc coliti show baicalein administr simultan amelior gut inflamm decreas intestin permeabl restor tight junction colon possibl via promot ahril pathway co administr ahr antagonist ch mgkg ip partial block therapeut effect baicalein coliti mice wherea ahr agonist ficz g ip amelior symptom gut barrier function coliti mice murin lymphocyt line mnk baicalein dose depend increas express ahr downstream target protein cypa enhanc il product facilit ahr nuclear transloc effect great diminish shahr mnk cell suggest baicalein induc il product ahr depend manner clarifi construct vitro system consist mnk caco cell mnk cell supernat treat baicalein could decreas fitc dextran permeabl promot express tight junction protein zo occlud caco cell conclus studi demonstr baicalein amelior coliti improv intestin epitheli barrier via ahril pathway ilc thus provid potenti therapi uc | D003092;D003093 | T047 |
34,671,108 | circadian time eat bmi among adult american time use survey experiment studi time restrict eat suggest limit daili eat window shift intak biolog morn avoid eat close biolog night may promot metabol health prevent weight gain | D015992 | T201 |
34,671,104 | indirect reduct ralstonia solanacearum via pathogen helper inhibit rhizospher microbiom form first line defens soilborn pathogen date microbiom enhanc strategi reli bioaugment antagonist microorgan direct inhibit pathogen previous studi shown root associ bacteria abl facilit pathogen growth therefor hypothes inhibit pathogen helper may help reduc pathogen densiti examin tripartit interact model pathogen ralstonia solanacearum two model helper strain collect bacteri isol recov tomato rhizospher system allow us examin import direct effect rhizobacteria pathogen growth indirect effect rhizobacteria helper growth pathway affect pathogen growth found interact rhizospher isol helper strain major determin pathogen suppress vitro vivo therefor propos control microbiom composit prevent growth pathogen helper may becom part sustain strategi pathogen control | D018551;D064307;D043368 | T007;T002;T001;T168;T032;T028 |
34,671,102 | metabol implic pancreat fat accumul fat accumul outsid subcutan adipos tissu often unfavour effect system metabol addit non alcohol fatti liver diseas receiv consider attent pancreat fat becom import area research throughout past year number diagnost approach avail quantifi pancreat fat multi echo dixon mri current develop method initi studi shown associ pancreat fat metabol syndrom impair glucos metabol type diabet mellitus pancreat fat link reduc insulin secret least specif circumst prediabet low bmi increas genet risk type diabet mellitus review summar possibl caus metabol consequ pancreat fat accumul addit potenti therapeut approach address pancreat fat accumul discuss | D003924;D007333;D065626;D011236 | T047;T046 |
34,671,100 | associ anti seizur medic outcom infant compar treatment failur infant treat phenobarbit versus levetiracetam first line treatment infant treat phenytoin versus levetiracetam second line treatment follow phenobarbit | D000927;D010634 | T121;T109 |
34,671,099 | pilot studi biochem effect repeat administr oral sucros vs oral dextros urinari marker adenosin triphosph degrad prematur neonat often receiv oral sucros dextros tissu damag procedur tdps previous work show singl dose sucros dextros increas cellular energi util atp degrad pilot studi probe effect repeat administr sucros dextros energi metabol | D000255;D013395 | T121;T114;T109;T123 |
34,671,097 | mice lack dyrk exhibit congenit malform lung hypoplasia alter foxf express gradient congenit malform caus life threaten diseas pediatr yet molecular mechan organogenesi poor understood show dyrk defici mice display congenit malform multipl organ transcriptom analysi reveal molecular patholog dyrk defici mice particular respect foxf reduct mutant pup exhibit sudden death soon birth due respiratori failur detail analys primordi lung earli development stage demonstr dyrk defici lead alter airway branch insuffici alveolar develop furthermor foxf express gradient mutant lung mesenchym disrupt reduc foxf target gene necessari proper airway alveolar develop ex vivo lung cultur system rescu express foxf target gene dyrk defici lung restor shh signal activ taken togeth demonstr dyrk essenti embryogenesi disrupt result congenit malform | D015870;D018507 | T045 |
34,671,096 | sar cov transmiss indoor profession sport event sport event spectat present risk covid pandem becom potenti superspread event result mass infect amongst particip sportspeopl spectat alik order prevent diseas transmiss mani profession sport bodi implement detail hygien regul report analyz sar cov transmiss profession sport event nd divis profession basketbal germani whilst social distanc context alway possibl rate infect signific reduc wear face mask cover mouth nose infect amongst individu continu wore medic particl filter mask categori knffp higher sport event | D008397;D000086402;D013177 | T056;T074;T005 |
34,671,095 | strong nutrient plant interact enhanc stabil ecosystem modular food web theori show weak energet flux result consumpt interact play major role stabil food web space time despit relianc energet flux food web theori surpris remain poor understood within ecosystem context natur focus materi flux time ecosystem theori employ modular nutrient limit ecosystem model understand limit nutrient alter structur dynam food web ecosystem theori overlook role key ecosystem interact strength eg plant nutrient r n mediat stabil nutrient limit ecosystem toward integr food web theori ecosystem theori first briefli review consum resourc interact c r highlight relationship structur c r interact stabil food web modul translat framework nutrient base system show nutrient plant interact behav coher extens current modular food web theori howev contrast rule weak c r interact tend stabil show strong nutrient plant interact potent stabil nutrient limit ecosystem model | D017753 | T070;T082 |
34,671,094 | newborn screen metabol panel reflect impact common disord pregnanc hypertens disord pregnanc matern diabet profound affect fetal newborn growth yet disturb intermedi metabol relev mediat fetal growth alter remain poor defin sought determin whether distinct newborn screen metabol pattern among newborn affect matern hypertens disord diabet utero | D016640;D046110;D011225 | T047;T046 |
34,671,093 | blood pressur organ dysfunct mortal preterm neonat late onset sepsi object studi investig associ systol diastol mean blood pressur sbp dbp mbp advers outcom preterm neonat late onset sepsi los | D003030;D018805 | T116;T047;T126;T046 |
34,671,091 | taxus yunnanensi genom offer insight gymnosperm phylogeni taxol product taxol natur product deriv taxus one effect natur anticanc drug biosynthet pathway taxol basi heterolog bio product report high qualiti genom assembl annot taxus yunnanensi base gb sequenc assembl chromosom contig n scaffold n mb mb respect phylogenom analys show yunnanensi close relat sequoiadendron giganteum among sampl taxa estim diverg time mya gymnosperm unlik angiosperm evid recent whole genom duplic yunnanensi repetit sequenc especi long termin repeat retrotransposon preval yunnanensi genom contribut larg genom size integr genom transcriptom data unveil cluster gene involv taxol synthesi locat chromosom gene famili encod hydroxylas taxol pathway exhibit signific expans studi contribut elucid gymnosperm relationship taxol biosynthet pathway | D019143;D018745;D010802 | T028;T062;T038;T078 |
34,671,089 | genom wide associ studi colorect polyp identifi high overlap polygen architectur colorect cancer genom wide associ studi gwas report colorect polyp overlap polygen background confer risk colorect cancer polyp remain unclear perform gwas subject colorect polyp use biobank japan data case control evalu genet correl colorect polyp cancer effect colorect polyp singl nucleotid polymorph snps known associ colorect cancer identifi cux known genet locus colorect cancer suscept locus colorect polyp p valu subsequ fine map analysi indic rs cux causal variant colorect polyp found known colorect cancer suscept snps also associ colorect polyp genet correl colorect cancer polyp high r p valu addit identifi signific loci colorect polyp three signific loci colorect cancer appli multi trait analysi gwas colorect cancer colorect polyp show similar germlin polygen featur give us addit insight potenti cancer polygen level patient polyp follow outpati clinic thus close observ polypectomi critic prevent colorect cancer | D003111;D015179 | T190;T191 |
34,671,088 | genet landscap cell identifi synthet lethal captur global gene network regul differenti immatur cell unbias manner larg scale forward genet screen zebrafish conduct combin genet interact analysi enu mutagenesi genet lesion associ failur cell develop identifi meiotic recombin map posit clone whole genom sequenc recess genet variant gene identifi confirm causat addit experi mutat affect cell develop perturb develop unrel cell type growth hormon express somatotroph provid import measur cell type specif genet variant structur genet network encompass identifi compon establish subsequ genet interact analysi identifi mani instanc posit allevi negat synthet genet interact sever exampl synthet lethal subsequ phenocopi use combin small molecul inhibitor drug interf normal cell develop also elicit remiss model cell acut lymphoblast leukaemia find illustr genet interact data obtain context entir organ exploit target interfer specif cell type malign deriv | D053263;D000072020 | T049;T044;T045 |
34,671,080 | discoveri character high affin potent sar cov neutral antibodi via singl b cell screen monoclon antibodi target sar cov high affin valuabl wide rang biomed applic involv novel coronavirus diseas covid diagnosi treatment prophylact intervent strategi rapid reliabl isol antibodi especi potent neutral antibodi critic toward improv covid respons inform futur respons emerg infecti diseas studi singl b cell screen use interrog antibodi repertoir immun mice isol antigen specif igg memori b cell use method high affin potent neutral antibodi identifi target receptor bind domain sar cov engin identifi molecul increas valenc result enhanc neutral activ mechanist investig reveal antibodi compet ace bind receptor bind domain sar cov antibodi may warrant develop urgent covid applic overal result highlight potenti singl b cell screen rapid reliabl identif high affin potent neutral antibodi infecti diseas applic | D000086402 | T005 |
34,671,064 | updat chieti affect action video databas older adult valid chieti affect action video caav databas replic sampl older adult age rang design experiment studi emot crucial take consider differ emot process young older adult therefor main goal present studi provid appropri dataset use caav age research reason caav administr data collect methodolog faith replic sampl older adult standard stimuli evalu emot dimens valenc arous caav valid older adult popul increas potenti use innov tool present valid support use caav databas futur experiment studi cognit function healthi patholog age | D001143;D004644 | T041 |
34,671,044 | three tier colloidosom microreactor continu flow catalysi integr colloidosom hierarch structur advanc function may serv biomimet microreactor carri catalyt reaction compartment biolog speci within semiperm membran despit recent progress colloidosom design integr biolog inorgan compon tier structur tackl remain challeng biocatalysi high demand report ration design three tier colloidosom via picker emuls process microreactor consist crosslink amphiphil silica polym hybrid nanoparticl semiperm shell enzym incorpor catalyt sub layer partial silicifi adsorpt lumen leverag confin enrich effect demonstr acceler lipas catalyz ester hydrolysi within microcompart organ inorgan hybrid colloidosom catalyt colloidosom assembl close pack column enzymat reaction continu flow format enhanc reaction rate three tier colloidosom provid reliabl platform integr function build block biomimet compartment microreactor spatial control organ high perform function | D019149 | T074 |
34,671,043 | import untest infecti individu intervent suppress covid impact extent test infecti individu suppress covid illustr earli stage outbreak germani hubei provinc china itali spain uk predict percentag untest infect individu depend specif outbreak found typic repres infect individu earli stage outbreak propos reduc under transmiss untest case crucial suppress virus achiev enhanc test combin social distanc intervent reduc transmiss wear face mask transmiss silent carrier kept control mean virus could fulli suppress fast isol contact trace test case | D008397;D000086402 | T074;T005 |
34,671,035 | popul structur biogeographi transmiss mycobacterium tuberculosi mycobacterium tuberculosi clonal pathogen propos co evolv human host millennia yet understand genom divers biogeographi remain incomplet use combin phylogenet dimension reduct reevalu popul structur tuberculosi provid depth analysi ancient indo ocean lineag modern central asian lineag expand understand lineag assess sub lineag use genom sequenc pan suscept strain find new genet distinct clade valid dataset independ isol find consist geograph restrict unrestrict pattern group includ three group lineag distribut termin branch length across tuberculosi phylogeni support hypothesi higher transmiss lineag comparison lineag global scale defin expand barcod singl nucleotid substitut allow rapid identif tuberculosi sub lineag addit intern group result paint higher resolut pictur tuberculosi phylogeni biogeographi | D010802 | T062;T078 |
34,671,026 | b h regul osteoclast differenti via type interferon depend ido induct function immun checkpoint molecul well known b famili protein also function regulatori molecul bone remodel b h receptor ligand b famili function primarili negat immun checkpoint regulatori function b h osteoblast differenti establish role osteoclast differenti remain unclear show b h high express matur osteoclast b h defici lead inhibit osteoclastogenesi human osteoclast precursor ocp high throughput transcriptom analys reveal b h inhibit upregul ifn signal well ifn induc gene includ ido pharmacolog inhibit type ifn ido knockdown lead revers b h defici mediat osteoclastogenesi suppress although synovi fluid macrophag rheumatoid arthriti patient express b h inhibit b h affect osteoclastogenesi thus find highlight b h physiolog posit regul osteoclast differenti implic type ifn ido signal downstream mechan | D002454 | T043 |
34,671,021 | erk modul il secret contribut tumor induc immun suppress tumor exhibit varieti strategi dampen antitumor immun respons aim identifi factor secret tumor cell perform unbias mass spectrometri base secretom analysi lung cancer cell interleukin il identifi promin factor secret tumor cell cancer associ fibroblast isol cancer patient incub dendrit cell dc cultur tumor cell supernat inhibit product il p dcs surfac express activ marker revers treatment il antibodi defect il p product dcs inhibit differenti th th th cell nave cd cell also demonstr classic mitogen activ protein kinas erkmapk requir il product tumor cell inhibit erk activ deplet erk prevent il product tumor cell could exploit enhanc antitumor immun respons | D007165 | T061 |
34,671,019 | ranbp promot glioblastoma progress regul fbxwc myc pathway ran bind protein ranbp ubiquit express evolutionarili conserv protein ran gtp exchang factor gef regul sever factor involv cellular progress previous studi show ranbp overexpress prostat cancer cell respons androgen receptor ar activ howev biolog function ranbp glioblastoma gbm studi found ranbp overexpress gbm high ranbp express close link poor surviv patient gbm downregul ranbp signific inhibit cell prolifer migrat invas tumor growth gbm cell addit reveal ranbp could suppress promot activ fbxw therebi increas protein stabil c myc gbm cell silenc fbxw ranbp knockdown gbm cell could part negat effect induc ranbp downregul taken togeth find establish ranbp signific promot gbm progress control fbxw c myc axi suggest ranbp may potenti target gbm | D018450;D015972;D015398 | T044;T045;T043;T046;T033 |
34,671,017 | bilobalid inhibit inflamm promot express degrad enzym astrocyt rescu neuron defici ad model pathogenesi alzheim diseas ad involv multipl cell type includ endotheli cell glia neuron suggest therapi singl target singl cell type may suffici treat ad therapi protect effect multipl cell type may effect comprehens investig effect bilobalid neuroinflamm degrad enzym ad cell model mous model find bilobalid inhibit induc stat depend express tnf il il primari astrocyt cultur bilobalid also induc robust express degrad enzym like nep ide mmp facilit astrocyt mediat clearanc moreov bilobalid treatment astrocyt rescu neuron defici co cultur appp neuron import bilobalid reduc amyloid inflamm ad mous brain taken togeth protect effect bilobalid vitro cultur fulli recapitul vivo ad mous model studi support bilobalid therapeut potenti ad treatment | D000544;D046935 | T048;T047;T109 |
34,671,015 | gak prkcd posit regul prkn independ mitophagi mechan involv program damag induc remov mitochondria mitophagi remain elus screen regul prkn independ mitophagi use sirna librari target protein contain lipid interact domain identifi cyclin g associ kinas gak protein kinas c delta prkcd regul prkn independ mitophagi dispens prkn depend mitophagi starvat induc autophagi demonstr kinas activ gak prkcd requir effici mitophagi vitro prkcd present mitochondria prkcd facilit recruit ulkatg earli autophag structur import demonstr vivo relev kinas regul basal mitophagi knockdown gak homologu gakh c elegan knockout prkcd homologu zebrafish led signific inhibit basal mitophagi highlight evolutionari relev kinas mitophagi regul | D063306 | T043 |
34,671,011 | map global preval depress among postpartum women postpartum depress ppd common psycholog condit follow childbirth may detriment effect social cognit health spous infant children aim studi complet comprehens overview current literatur global epidemiolog ppd total studi differ countri region includ final analysi postpartum depress found ci world popul meta regress analysi show studi size countri region develop countri region incom caus heterogen multivari meta regress analysi found studi size countri area develop import predictor vari preval rate note geograph region highest rate found southern africa interest signific lower rate ppd develop countri high incom countri area furthermor find show substanti differ rate ppd marit status educ level social support spous care violenc gestat age breast feed child mortal pregnanc plan financi difficulti partnership life stress smoke alcohol intak live condit consid pool estim result indic one everi five women experi ppd link incom geograph develop trigger varieti caus necessit attent commit intervent primari care provid clinician health author general popul | D003863;D019052 | T048;T184 |
34,671,009 | mrna target transport local translat eukaryot cell classic view divers new concept spatial organ protein biosynthesi eukaryot cell studi fifti year thus mani fact alreadi includ textbook accord classic view mrna transcript encod secret transmembran protein translat ribosom associ endoplasm reticulum membran solubl cytoplasm protein synthes free polysom howev last year new data emerg reveal select translat mrna mitochondria plastid proxim peroxisom endosom various granul cytoskeleton actin network vimentin intermedi filament microtubul centrosom also long stand debat possibl protein synthesi nucleus local translat determin target signal synthes protein nucleotid sequenc mrna rna bind protein mani transcript assembl specif rna condens form rnp particl may transport molecular motor site activ translat form granul provok liquid liquid phase separ cytoplasm normal condit cell stress translat mrnas occur special translat factori assemblysom transperon structur necessari correct fold protein interact function partner format oligomer complex intracellular local mrna signific impact effici translat presum determin respons cellular stress compartment mrnas translat machineri also play import role viral infect mani virus provok format specif intracellular structur virus factori product protein review current concept molecular mechan transport select local local translat cellular viral mrnas effect protein target topogenesi regul protein biosynthesi differ compart eukaryot cell special attent paid new system biolog approach provid new cue studi local translat | D005057;D012270 | T025;T026 |
34,671,008 | mitoxantron inhibit fmlp induc degen chang human neutrophil neutrophil fight invad pathogen various mechan includ degranul phagocytosi releas neutrophil extracellular trap net studi aim determin impact synthet formyl peptid fmlp human neutrophil vitro determin role mitoxantron mtx pharmacolog blocker mitochondri ca uniport mcu fmlp induc alter isol neutrophil whole blood prepar neutrophil pre treat mtx stimul fmlp field stain smear brightfield microscopi employ morpholog character quantif neutrophil releas cell free dna cfdna also measur determin neutrophil damag data demonstr degen chang neutrophil greater cfdna releas upon stimul fmlp negat associ presenc rest platelet whole blood prepar interest mtx pre treatment signific reduc fmlp trigger neutrophil damag cfdna releas metformin known inhibitor net format also decreas fmlp induc chang neutrophil addit confirm degen potenti fmlp studi reveal novel contribut mcu regul fmlp induc morpholog alter human neutrophil | D008942;D009504 | T025;T121;T109 |
34,671,007 | anxa regul prolifer human non small lung cancer cell via egfr akt mtor signal pathway annexin anxa member annexin famili report regul multipl cancer cellular process includ prolifer metastasi inflamm howev specif role anxa lung cancer cell biolog remain unknown previous transcriptom studi reveal anxa mrna downregul curcumin analog mhmd treat human non small lung cancer cell cell line continu studi anxa express cell use revers transcript quantit pcr western blot compar human normal bronchial epithelium cell b cell line overexpress anxa via transfect pegfp anxa recombin vector contribut prolifer migrat cell moreov cell cycl protein cyclin e upregul anxa transfect cell knockdown anxa use rna interfer techniqu decreas cell viabil restrain migrat vitro express level multipl cellular factor includ egfr pik akt mtor psk ebp epiderm growth factor receptor egfr signal pathway also alter anxa knockdown overexpress cell confirm activ egfraktmtor signal pathway anxa present result provid evid support investig function identif anxa lung cancer cell futur | D008175;D051057 | T191;T116;T126 |
34,671,006 | luciferas egfp report system evalu dna methyl mammalian cell dna methyl essenti epigenet modif involv numer biolog process present cell base system pltr lucp egfp evalu dna methyl mammalian cell system express report gene luciferasep lucp egfp control hiv promot long termin repeat ltr contain multipl cpg site site methyl express lucp egfp turn may visual fluoresc microscopi quantif perform luciferas activ assay proof principl pltr lucp egfp methyl vitro transfect cell reduct lucp egfp express confirm premix report dna sampl methyl level vari use quantit measur dna methyl result standard curv indic accuraci luciferas activ exceed western blot egfp bland altman analysi show data luciferas activ assay good agreement actual dna methyl level summari establish report system coupl reliabl detect techniqu capabl effici quantifi chang methyl mammalian cell system may util high throughput screen tool identifi molecul modul dna methyl | D019175;D044127 | T044;T045 |
34,671,005 | determin subclon tumor structur childhood acut myeloid leukemia acral melanoma next generat sequenc intratumor heterogen clonal variabl among central problem clinic oncolog lead resist therapi relaps metastasi high throughput sequenc tumor exom make possibl investig subclon tumor organ target panel clinic exom complet exom sequenc data compar tumor differ mutat burden acut myeloid leukemia aml children acral melanoma target sequenc aml sampl detect one potenti driver mutat signal pathway gene kit nras kras cbl flt one patient reflect complex clonal structur tumor substrat cluster mutant allel correspond differ popul leukem cell sampl isol base exom sequenc data aml patient comparison mutat profil primari aml sampl sampl obtain remiss relaps made possibl trace dynam chang clonal composit tumor subclon tumor structur investig acral melanoma case exampl mutant allel present sampl close frequenc cluster use sciclon clonevol packag result use predict intratumor clonal composit assum clonal evolut model describ chang clonal composit tumor metastasi includ appear new mutat might associ diseas progress approach use work suitabl identifi mutat caus format new tumor clone may prolif advantag particular condit antitumor therapi | D015470;D008545;D012878 | T191 |
34,671,004 | guanin quadruplex cell nucleus metabol cell metabol depend larg extent correct regul gene express one mechan regul format nucleic acid secondari structur among guanin quadruplex g quadruplex g particular import g quadruplex dynam structur whose stabil determin size ionic composit natur nucleic acid form regul various protein factor guanin quadruplex play import role regul mani process occur dna rna maintain telomer homeostasi determin ribosom land site mrna therefor structur consid promis target antitumor therapi detail studi import modern biolog review focus structur thermodynam properti g quadruplex togeth interact nuclear protein | D054856 | T086 |
34,671,003 | structur function evolutionari characterist protein repeat review summar systemat data classif taxonom distribut structur featur function protein structur repeat modern approach identif structur repeat protein consid featur special databas protein domain describ review discuss prospect use repeat contain protein scaffold drug design role protein structur repeat pathogenesi various diseas consid various modern approach understand mechan evolutionari develop protein repeat describ analyz | D019143;D011506 | T116;T038;T123 |
34,671,002 | beta amyloid tau protein neuroinflamm attempt integr differ hypothes alzheim diseas pathogenesi alzheim diseas ad neurodegen diseas inevit result dementia death current pathogenet ground method prevent treatment ad current treatment regimen symptomat unabl signific delay develop dementia accumul amyloid peptid spontan aggreg prone neurotox product process signal protein app amyloid precursor protein brain tissu primarili hippocampus frontal cortex long time consid main caus neurodegen chang ad howev attempt treat ad base decreas product aggreg bring signific clinic result argument aris favor fact overproduct case ad initi caus concomit event patholog process cours develop sporad ad concept neuroinflamm come fore suggest inflammatori respons play lead role initi develop ad brain tissu peripheri hypothesi key role neuroinflamm pathogenesi ad open new opportun search way treat prevent social signific diseas | D000544;D019636 | T048;T047 |
34,671,001 | transcript factor direct neuron reprogram ontogenesi ex vivo direct reprogram technolog allow sever specif type cell includ special neuron obtain readili avail autolog somat cell present uniqu opportun develop person medicin vitro model hereditari degen neurolog diseas novel neuroregen technolog past decad plethora protocol primari reprogram publish yet reproduc generat homogen popul neuron reprogram cell still remain challeng exist protocol howev use transcript factor involv embryon neurogenesi presum key issu obtain high effici reproduc protocol ex vivo neurogenesi analysi function featur transcript factor embryon adult neurogenesi may lead improv reprogram protocol also via cell marker analysi exact determin stage neurogenesi particular protocol reach purpos review character general factor play key role neurogenesi embryon adult period well cellular reprogram assess correspond cell form obtain result cellular reprogram ontogenet seri nervous system pluripot stem cell special neuron | D065150;D014157 | T043;T062;T116;T123 |
34,671,000 | treatment sever immun thrombocytopen purpura associ covid background covid associ mani hematolog manifest includ lymphopenia thrombosi rare occas thrombocytopenia report sole clinic present covid case report case report year old hispan femal patient covid present sever isol thrombocytopenia patient present emerg depart hemoptysi spontan bruis excess vagin bleed also report recent flu like ill examin found bilater subconjunctiv hemorrhag diffus oral ulcer epigastr abdomin tender ecchymosi chest scatter petechia palpabl purpura lower limb laboratori result signific platelet count immatur platelet fraction owe clinic suspicion patient test covid test result posit treat intraven immunoglobulin prednison rituximab vitamin c zinc upon achiev hemodynam stabil discharg follow hematologist outpati set conclus hematolog consequ covid becom preval mechan behind manifest could bone marrow failur format platelet autoantibodi consumpt coagulopathi critic manifest necessari manag especi sever form like patient steroid rituximab combin therapi proven effect regimen | D000086382;D016553;D013921 | T047;T067 |
34,670,999 | integr intrins radiosensit immun status predict benefit radiotherapi head neck squamous cell carcinoma background hnscc head neck squamous cell carcinoma heterogen diseas radiotherapi main treatment intrins radiosensit immun status affect initi effect stage radiat induc cancer immun cycl respect import consid select patient benefit radiotherapi materi method studi includ hnscc patient complet surviv radiotherapi inform tcga databas patient divid rs radiosensit rr radioresist immun non immun group accord rsi radiosensit index immun score calcul estim algorithm surviv analysi perform compar os overal surviv patient receiv receiv radiotherapi go kegg pathway enrich analysi perform function analysi univari cox ridg regress analysi perform construct predict gene signatur base combin stratif result patient rs immun group could benefit radiotherapi surviv analysi result remain consist perform propens score match patient receiv receiv radiotherapi differenti express gene rs immun non rs immun group main enrich pathway relat immun process gene signatur built exhibit predict valu train valid cohort treat binari continu variabl conclus combin stratif intrins radiosensit immun status superior consid intrins radiosensit immun status alon could use preclin evalu select patient decid whether radiotherapi sensit immunotherapi use time | D014408;D011836 | T032;T123 |
34,670,998 | phenotyp acut respiratori distress syndrom state art clinic implic decad research acut respiratori distress syndrom ard led intervent impact clinic outcom pandem patient ard due novel sar cov infect stress need effect therapi ard phenotyp may enabl success trial precis therapeut patient popul | D000086382;D012128 | T047;T067 |
34,670,997 | extracorpor membran oxygen coronavirus diseas relat acut respiratori distress syndrom understand potenti role extracorpor membran oxygen ecmo coronavirus diseas covid relat acut respiratori distress syndrom ard highlight evolv practic outcom | D000086382;D015199;D012128 | T047;T061;T067 |
34,670,996 | associ oral health cardiovascular outcom patient hypertens nationwid cohort studi studi associ oral hygien indic cardiovascular diseas hypertens patient lack oral hygien direct indirect associ system inflamm one essenti mechan cardiovascular diseas therefor hypothes oral hygien would relat risk cardiovascular diseas hypertens patient | D003731;D006973;D009203 | T033;T047 |
34,670,995 | serum cortisol cortison ratio deoxycortisol associ hypertens blood pressur chines rural popul cross section studi present studi aim investig associ cortisol cortison ratio fe deoxycortisol hypertens blood pressur among chines rural popul | D003348;D006973 | T047;T121;T109;T125 |
34,670,994 | effect weight pain manag program patient rheumatoid arthriti obes random control pilot investig obes associ poor outcom patient rheumatoid arthriti ra effect weight manag imper although tradit lifestyl behavior weight loss program demonstr efficaci reduc weight intervent meet pain relat weight loss challeng ra patient obes | D001172;D059408 | T047;T061 |
34,670,993 | burnout rheumatologist latin america rheumatolog consid low risk specialti studi shown preval burnout | D002055;D012219 | T091;T048 |
34,670,991 | develop covid vaccin readi kit veteran rheumatolog diseas immunomodul qualiti improv project advent multipl safe effect vaccin prevent sar cov infect repres major step resolv covid global pandem vaccin individu rheumatolog diseas immunomodul repres addit challeng data suggest certain immunomodul may impact vaccin efficaci | D001172;D000086382;D014728 | T047;T098;T067 |
34,670,989 | impact covid lockdown spinal servic nation level lesson learn area servic improv futur health care deliveri coronavirus diseas covid pandem dramat impact provis health care worldwid deliveri nation spinal servic emerg surgeri elect surgeri outpati assess incred challeng varieti innov measur undertaken facilit safe provis acut servic outlin review along number key learn point improv qualiti health care deliv come year challeng face spinal surgeri communiti regard reintroduct elect surgeri discuss potenti roadmap safe resumpt servic present | D000086382 | T047;T067 |
34,670,988 | laryngoscop screen revis anterior cervic spine surgeri vocal cord palsi relev factor decid approach direct retrospect studi | D014826 | T033;T047 |
34,670,987 | investig therapi gunshot wound spine narrat review narrat review | D013119;D014948 | T037 |
34,670,986 | time total hip arthroplasti affect lumbar spinal fusion outcom retrospect cohort studi consecut patient undergo lumbar spinal fusion lsf within pearldiv humana research databas | D019644;D013123 | T061 |
34,670,985 | ultrasound lancet aid translaminar posterior lumbar approach recesso foramin area technic note extrus sequestr nucleus pulposus involv spinal canal foraminarecess complic lumbar disc herniat transparstranslaminar anatom approach well describ advantag handl later foramin extrud disc herniat appreci recogn nevertheless approach present sever pitfal risk disconnect par interarticulari may caus segment instabl particular eventu particular anatom conform par interarticulari although alreadi part modern surgic armamentarium general orthoped cranial spinal surgeon use ultrason scalpel techniqu approach never discuss date best knowledg purpos present paper therefor introduc describ stepwis techniqu along extens discuss facilit role ultrason scalpel translaminartranspar approach manag extrud disc herniat lumbar spine | D007405 | T047 |
34,670,983 | incid new onset obstruct sleep apnea posterior flap pharyngoplasti children obstruct sleep apnea osa well recogn complic velopharyng insuffici vpi surgeri studi assess osa mean respiratori polygraphi pg scarc aim studi evalu incid new onset osa posterior flap pharyngoplasti pfp | D002972;D020181;D014681 | T047;T019 |
34,670,981 | applic modifi kite flap repair facial skin defect tumor resect kite flap wide use repair facial skin defect high surviv rate simpl oper howev flap mobil tradit kite flap limit need improv conduct survey evalu clinic efficaci modifi kite flap repair facial skin defect tumor resect | D061525;D019651;D017695 | T037;T023;T061 |
34,670,976 | takotsubo syndrom periop period case report comprehens review pertin literatur stress induc cardiomyopathi takotsubo syndrom rare nonischem heart condit resembl acut coronari syndrom distinct featur transient wall motion abnorm occur usual apic segment heart degre symptom manifest sever vari among patient although earli data support benign sequela outcom high degre advers event acut heart failur pulmonari edema anticip mortal rate approach hyperactiv sympathet nervous system adrenerg drug point possibl precipit condit surgic procedur known caus emot physic stress patient act ideal substrat present syndrom occas periop takotsubo syndrom case femal patient second stage implant base breast reconstruct review pertin literatur present acut onset sever manifest surgic unev procedur necessit multidisciplinari approach consequ report rais awar syndrom among plastic surgeon anesthesiologist prompt recogn manag effect | D054549 | T047 |
34,670,974 | potenti impact covid aesthet fellowship program covid pandem brought immens chang health care surgic specialti particular make major adjust cancel nonemerg surgeri aesthet surgeri fellowship uniqu affect high number elect case length fellowship impact covid pandem current upcom aesthet surgeri fellow studi | D000086382;D005257 | T065;T047;T078;T067 |
34,670,973 | membran like structur extensor tendon nail distal end digit anatom studi structur function util nail structur cadav investig digit hand histolog studi thick length locat sep measur digit cadav cadav move distanc sep measur macroscop distal interphalang joint flexion degre confirm function move distanc could consid indic sep strain surround retain structur improv stabil nail pinch | D005384;D013710 | T023;T030 |
34,670,972 | outcom cranioplasti strategi high risk complex cranial defect year experi although literatur contain report risk complic calvari vault reconstruct acquir defect public address specif patient popul requir reconstruct case preced prior infect radiat massiv associ soft tissu trauma defin clinic present hostil environ larg surfac area reconstruct object compar safeti efficaci autolog bone alloplast reconstruct hostil cranial defect | D019904;D019651 | T061;T122;T109 |
34,670,971 | clinic applic musculoperiost iliac flap osteonecrosi femor head osteonecrosi femor head onfh often affect young activ patient femor head preserv primari goal treatment diseas vascular iliac crest bone graft one mani vascular procedur use treat onhf case select perform procedur use musculoperiost iliac flap ascend branch later femor circumflex arteri onfh treatment | D005270;D005271 | T047;T023;T046 |
34,670,969 | nationwid resid access elect rotat survey studi studi seek assess status elect rotat offer plastic reconstruct surgeri resid program throughout countri also qualifi resid alumni experi identifi barrier offer elect | D007396;D013518 | T097;T065;T091 |
34,670,968 | accuraci soft tissu predict method doubl jaw orthognath surgeri class iii patient aim evalu accuraci valid convent manual predict method cm dimension dimension soft tissu predict method class iii bimaxillari orthognath surgeri patient | D057909;D056948 | T091;T061 |
34,670,967 | function aesthet lower lip reconstruct use yotsuyanagi flap lower lip defect major challeng reconstruct perspect lower lip anatom region form differ type tissu essenti obtain adequ function aesthet result local tissu avail donor area becom best option repair defect articl purpos present experi reconstruct partial transfix total defect lower lip musculocutan flap depressor anguli ori describ yotsuyanagi | D008048;D064827;D019651 | T191;T024;T061 |
34,670,966 | close incis negat pressur therapi decreas wound morbid open abdomin wall reconstruct concomit panniculectomi patient undergo abdomin wall reconstruct awr concomit panniculectomi cp may higher risk wound complic due need larg incis tissu undermin aim studi evalu whether use close incis negat pressur therapi cinpt decreas wound complic awr patient undergo cp | D034861;D061645;D054843;D000072836 | T037;T074;T023;T061 |
34,670,965 | reconstruct distal nasal defect larg postauricular skin fat fascia composit graft composit graft previous report achiev good outcom nasal defect repair composit graft greater metabol need simpl skin therefor tradit recommend size composit graft nasal reconstruct less cm diamet howev distal nose general well suppli blood vessel might support use larger composit graft high vascular recipi site aim articl investig whether larg skin fat fascia composit graft larger cm viabl repair partial thick nasal defect | D012225 | T061 |
34,670,964 | revisit arteri suppli anterior ear sinc arteri suppli anterior ear describ park et al various anatom studi surgic techniqu publish literatur although anatom studi vascular pattern ear previous report incomplet understand vascular anatomi ear surgic outcom report author defin detail vascular pattern arteri network main perfor anterior ear | D054644;D019651 | T023;T061 |
34,670,963 | anococcyg nerv sit pain differenti diagnosi treatment result plastic surgeon often ask reconstruct sacral area relat pilonid cyst tumor surgeri coccygectomi sit pain due pudend posterior femor cutan nerv injuri anococcyg nerv acn must consid clinic anatomi well known rather consid coccygectomi tradit nonop treatment coccydynia fail resect acn might consid | D003050;D010146 | T023;T184 |
34,670,962 | systemat stepwis method perform supermicrosurg lymphoven anastomosi lymphoven anastomosi lva becom increas common treatment patient extrem lymphedema articl present current strategi patient select preoper plan seri intraop clue may help perform supermicrosurg lva technic consider present use systemat step step method make procedur reproduc straightforward | D042601;D008209 | T047;T023;T046 |
34,670,961 | estrogen ethinyl estradiol sulfat reduc mortal swine model multipl injuri hemorrhag shock although ethinyl estradiol sulfat ee reduc mortal anim model control hemorrhag role clinic relev injuri model unknown assess impact ee swine model multipl injuri hemorrhag | D012771 | T046 |
34,670,960 | time everyth impact combin long bone fractur major arteri injuri outcom time extrem fractur fixat patient associ major vascular injuri remain controversi favor temporari fractur fixat definit vascular repair limit potenti graft complic other advoc immedi revascular minim ischem time purpos studi evalu time fractur fixat outcom patient concomit long bone fractur major arteri injuri | D001158;D005121;D005592;D007511;D009104;D014656;D057772 | T037;T023;T061;T046 |
34,670,959 | emerg general surgeri transfer lower acuiti facil role right size care emerg general surgeri region region emerg general surgeri eg primarili focus expedit care high acuiti patient interfacil transfer contrast triag low risk patient nondesign trauma facil evalu studi evalu month experi five surgeon team triag eg patient tertiari care level trauma center tc affili communiti hospit mile away | D003422;D010360;D020379;D014218 | T058;T061;T081 |
34,670,956 | decad patient experi improv tertiari care urban hospit purpos qualiti manag studi demonstr one hospit made journey averag patient experi becom region leader experi patient care nation recogn qualiti safeti metric | D061214;D017060 | T058;T080 |
34,670,955 | evalu implement best practic gestat diabet model care two australian metropolitan servic dissemin local adapt best practic model care often poor achiev knowledg translat process understand document iter cycl improv elucid barrier enabl benefit process futur adopt servic integr improv project examin process local adapt third stage translat gestat diabet dietet model care collabor two queensland australia hospit | D000086382;D016640 | T047;T067 |
34,670,954 | explor social demograph factor determin intestin inflamm low birth weight infant low birth weight vlbw infant disproportion affect inflammatori morbid includ necrot enterocol despit influenc social demograph factor infant health outcom relationship intestin inflamm unknown | D020345;D019102 | T047;T184 |
34,670,953 | nurs care infant born mother covid novel coronavirus diseas covid spread throughout world yet report neonat case thus inform relat clinic care experi scarc | D000086382;D011251 | T047;T067 |
34,670,952 | silico analysi de novo otc variant caus ornithin transcarbamylas defici ornithin transcarbamylas defici otcd common x link hereditari disord urea cycl disord caus neonat hyperammonemia otc gene sequenc variat common caus otcd current studi present month old babi girl proband phenotyp characterist otcd irrit somnol intermitt vomit high level serum ammonium whole exom sequenc reveal de novo cg p arggln variant within otc gene silico analysi reveal possibl differenti affin wild type mutant otcas arggln decreas bind abil otcas substrat disrupt urea cycl explain molecular pathogen clinic hyperammonemia light fact genotyp phenotyp correl otcd still uncertain present silico analysi outcom enhanc knowledg complic rare sever genet disord | D022124;D020163 | T047 |
34,670,951 | covid mask toward understand social mean respons covid pandem impos unpreced restrict everyday life unlik lockdown shelter place measur facemask emerg empow respons public spread virus permit degre return prepandem life school work disrupt transmiss would otherwis occur yet utilitarian tool attract consider controversi polar opinion articl use blumer adapt symbol interaction theoret roadmap examin various mean ascrib facemask usag discuss social perceiv consid implic health care provid within canadian social context | D000086382 | T047;T067 |
34,670,946 | punch rescu techniqu scleral fixat disloc singl piec intraocular lens bag intraocular len iol disloc well known complic cataract surgeri number cataract surgeri perform annual continu increas incid iol disloc requir surgic correct describ new techniqu rescu refix singl piec acryl iol method new instrument call iol punch use creat hole optic haptic junction along border optic act anchor point centrat subsequ scleral fixat disloc iol iol punch allow precis intraocular manipul iol less invas compar popular scleral fixat method innov techniqu may decreas risk postop complic allow patient maintain recov previous uncorrect visual acuiti circumv need iol explant exchang | D007910 | T074 |
34,670,942 | syphili greenland increas incid syphili report greenland notif rate kept rise follow year spite focus effort better understand syphili epidem studi conduct describ syphili epidem greenland | D012749;D013587 | T047 |
34,670,941 | factor associ partner notif test posit hiv partner servic program unit state human immunodefici virus hiv partner servic essenti compon comprehens hiv prevent care examin factor associ partner notif hiv test hiv posit among partner hiv diagnos person index person contact center diseas control prevent cdc fund state local health depart | D015658;D006679 | T034;T047 |
34,670,929 | construct analysi digit mammographi databas analysi breast compress pressur four facil analyz compress pressur mammographi imag patient acquir digit mammographi equip four facil analysi includ averag compress pressur facil differ compress pressur facil differ pressur use radiolog technologist facil differ attribut breast structur also analyz effect compress pressur breast thick mean glandular dose mgd facil median valu compress pressur breast thick imag facil n mm respect compress pressur differ among institut maximum differ median pressur among four facil n differ breast thick mm radiolog technologist work facil use almost compress pressur howev differ compress pressur use differ radiolog technologist observ compress pressur dens breast smaller non dens breast differ compress pressur affect breast thick mgd result analysi could util optim imag futur digit mammographi | D001943;D008327 | T191;T060 |
34,670,928 | use clinic signific thin slice gapless coron diffus weight imag acut brainstem infarct diagnosi lesion caus brainstem infarct usual small therefor often difficult diagnos use axial diffus weight imag axial dwi purpos studi evalu use thin slice gapless coron dwi acut brainstem infarct diagnosi differ elaps time onset cerebr infarct | D020526;D038524 | T047;T060 |
34,670,927 | evalu fat suppress effect snr use pixel shift method fat suppress imag chess ideal head neck mr imag studi aim evalu fat suppress effect imag head neck region use chemic shift select chess iter decomposit water fat echo asymmetri least squar estim ideal | D006257;D008279 | T170;T029;T059;T060 |
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