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https://en.wikipedia.org/wiki/MediaTek | MediaTek Inc. () is a Taiwanese fabless semiconductor company that provides chips for wireless communications, high-definition television, handheld mobile devices like smartphones and tablet computers, navigation systems, consumer multimedia products and digital subscriber line services as well as optical disc drives.
Founded in 1997 and headquartered in Hsinchu, the company has 41 offices worldwide and was the third largest fabless chip designer worldwide in 2016. The company also provides its customers with reference designs. MediaTek became the biggest smartphone chipset vendor with 31% market share in Q3 2020. This was assisted by its strong performance in regions such as China and India.
Corporate history
MediaTek was originally a unit of the Taiwanese firm, United Microelectronics Corporation (UMC), tasked with designing chipsets for home entertainment products. On May 28, 1997, the unit was spun off and incorporated. MediaTek Inc. was listed on the Taiwan Stock Exchange (TSEC) under the "2454" code on July 23, 2001.
The company started out designing chipsets for optical drives and subsequently expanded into chips for DVD players, digital TVs, mobile phones, smartphones and tablets. In general MediaTek has had a strong record of gaining market share and displacing competitors after entering new markets.
The company launched a division to design products for mobile devices in 2004. Seven years later, it took orders for more than 500 million mobile system-on-chip uni |
https://en.wikipedia.org/wiki/Crystal%20Blaze | Crystal Blaze was a Finnish metal band.
Biography
The band was formed in 1995 and started first playing power metal under the name Guardian Force. Over the years, the group has gone through changes and the band started to take its current form in 2001, when Lari Sorvo (keyboards) and Lauri Koskenniemi (guitar) joined the founding members Mikael Grönroos (guitar), Max Obstbaum (vocals) and Gustaf Standertskjöld (drums) with the bassist Eerik Purdon. Now that the band performs and records under the name Crystal Blaze, the musical genre has also changed. The group is not afraid of combining different styles and genres with metal. Crystal Blaze's first demo Dreams was published in 2004 and was recorded at the MusaMuusa studios. The second demo The Punishment was released in 2006. In 2007, Crystal Blaze parted ways with one of the founding members of the band, drummer Gustaf Standertskjöld. Crystal Blaze was the winner of 2007 Wacken Metal Battle Finland and also performed at Wacken Open Air 2007 festival in Germany. In March 2008, the band released its third release named Beneath the Sands. At the same time the band also announced Juhana Karlsson as a new drummer. The band was split up in 2010.
Band members
Max Obstbaum - vocals
Mikael Grönroos - guitar
Lauri Koskenniemi - guitar
Eerik Purdon - bass
Lari Sorvo - keyboards
Juhana Karlsson - drums
Discography
Dreams (2004)
The Punishment (2006)
Beneath the Sands (2008)
External links
Crystal Blaze @ Mikseri
Crystal Blaze @ MySp |
https://en.wikipedia.org/wiki/Battle%20of%20Qurna%20%28Iraq%20War%29 | Battle of Qurna was a battle during the Iraq War between the Multinational force in Iraq and Iraqi insurgents. The battle took part in Al-Qurna. In the battle, the insurgents tried to take the control of the city from the allies, mainly Danish, Lithuanian and British soldiers. The insurgents were later forced to retreat.
Aftermath
The main fighting element in the battle was the Lithuanian Mechanized Infantry Platoon.
After the battle, the allies took control of Qurna. The Danish soldier, Sergeant Ole Gretlund was awarded The Defence Medal for saving the lives of the Lithuanian soldiers.
Battles of the Iraq War in 2005
Battles of the Iraq War involving the United Kingdom
Battles of the Iraq War involving Denmark
Iraqi insurgency (2003–2011)
May 2005 events in Iraq |
https://en.wikipedia.org/wiki/Richard%20Grimsdale | Richard Lawrence Grimsdale (18 September 1929 – 6 December 2005) was a British electrical engineer and computer pioneer who helped to design the world's first transistorised computer.
Early life and education
Richard Lawrence Grimsdale was born on 18 September 1929 in Australia, where his father, an English engineer, was working on construction of the suburban railway system for the Metropolitan-Vickers company. The family returned to England, where he was educated at Manchester Grammar School, and then studied electrical engineering at the University of Manchester, where he earned his Bachelor of Science, his Master of Science in 1951, writing a thesis on Computing Machines - Design of Test Programmes, and subsequently his Doctor of Philosophy, writing his thesis on the Transistor Digital Computer under the supervision of Frederic Calland Williams.
Career
In 1953, whilst still a post-graduate research student at the University of Manchester, Grimsdale achieved one of the first major landmarks in his career with his design and development work on the Metrovick 950, the world's first computer made from transistors rather than valves or electromechanical devices. The computer used early point-contact transistors which were the first generation of transistors, however later developments of the machine used more advanced junction transistors which offered better performance.
Grimsdale also worked on the Ferranti Mark I computer, a commercial development of the Manchester Mark |
https://en.wikipedia.org/wiki/IL22RA2 | Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22 binding protein (IL-22BP) is a naturally secreted monomeric protein acting as an interleukin-22 (IL-22) antagonist with inhibitory effects on IL-22 activity in vivo. IL-22BP is in humans encoded by the IL22RA2 gene located on chromosome 6, and in mice is encoded by the il22ra2 gene located on chromosome 10. IL-22BP belongs to the class II cytokine receptor family and it is a soluble receptor homolog of IL-22R (aliases IL-22RA1/IL-22RA/IL-22R1).
The main function of IL-22BP is the regulation of IL-22 biological activity through specific binding which blocks the interaction of IL-22 with its cell surface receptor IL-22R and thus prevents the downstream cellular signalling and response. IL-22 and IL-22BP interactions play an important role in health and disease and are involved in the regulation of steady-state homeostasis, inflammatory responses and cancer.
Structure and interaction
IL-22BP is a soluble monomeric cytokine receptor protein. IL-22BP shares approximately 34% sequence homology with the extracellular domain of one subunit of the heterodimeric membrane-bound IL-22R, which is the main cellular receptor for IL-22 providing the subsequent signalling. This homology extends to the secondary and tertiary structure of the proteins allowing specific binding and protein-protein interactions. IL-22BP also shares homology with other related cytokine receptors IL-10RB, and IL-20RA. IL-22BP is a s |
https://en.wikipedia.org/wiki/Hellinger%20distance | In probability and statistics, the Hellinger distance (closely related to, although different from, the Bhattacharyya distance) is used to quantify the similarity between two probability distributions. It is a type of f-divergence. The Hellinger distance is defined in terms of the Hellinger integral, which was introduced by Ernst Hellinger in 1909.
It is sometimes called the Jeffreys distance.
Definition
Measure theory
To define the Hellinger distance in terms of measure theory, let and denote two probability measures on a measure space that are absolutely continuous with respect to an auxiliary measure . Such a measure always exists, e.g . The square of the Hellinger distance between and is defined as the quantity
Here, and , i.e. and are the Radon–Nikodym derivatives of P and Q respectively with respect to . This definition does not depend on , i.e. the Hellinger distance between P and Q does not change if is replaced with a different probability measure with respect to which both P and Q are absolutely continuous. For compactness, the above formula is often written as
Probability theory using Lebesgue measure
To define the Hellinger distance in terms of elementary probability theory, we take λ to be the Lebesgue measure, so that dP / dλ and dQ / dλ are simply probability density functions. If we denote the densities as f and g, respectively, the squared Hellinger distance can be expressed as a standard calculus integral
where the second form can be obta |
https://en.wikipedia.org/wiki/List%20of%20Bradford%20Bulls%20records%20and%20statistics | This is a list of all the records and statistics of rugby league side Bradford Bulls. It concentrates on the records of the team and the performances of the players who have played for this team. Since the re-brand in 1996 the Bulls have gone on to win many honours and awards. Under the re-brand the Bulls played their first game against Batley Bulldogs in the 1996 Challenge Cup on 4 February 1996, Bradford won the match 60–18. As of 7 October 2021 the Bulls have played 788 games.
Team records
Team wins, losses, ties and draws
Matches played
Results summary
Highest scores
Lowest scores
Biggest wins
Biggest losses
Individual records
Most matches as captain
Most career appearances
Most career points
Most career tries
Most career goals
Most career drop goals
Most points in a season
Most tries in a season
Most goals in a season
Most drop goals in a season
Most points in a match
Most tries in a match
Most goals in a match
Most drop goals in a match
Attendance records
Season average attendance
Highest match attendance
Coaching
Coaching records
References
Statistics |
https://en.wikipedia.org/wiki/Scattering-matrix%20method | In computational electromagnetics, the scattering-matrix method (SMM) is a numerical method used to solve Maxwell's equations, related to the transfer-matrix method.
Principles
SMM can, for example, use cylinders to model dielectric/metal objects in the domain.
The total-field/scattered-field (TF/SF) formalism where the total field is written as sum of incident and scattered at each point in the domain:
By assuming series solutions for the total field, the SMM method transforms the domain into a cylindrical problem. In this domain total field is written in terms of Bessel and Hankel function solutions to the cylindrical Helmholtz equation. SMM method formulation, finally helps compute these coefficients of the cylindrical harmonic functions within the cylinder and outside it, at the same time satisfying EM boundary conditions.
Finally, SMM accuracy can be increased by adding (removing) cylindrical harmonic terms used to model the scattered fields.
SMM, eventually leads to a matrix formalism, and the coefficients are calculated through matrix inversion. For N-cylinders, each scattered field modeled using 2M+1 harmonic terms, SMM requires to solve a N(2M + 1) system of equations.
Advantages
SMM, is a rigorous and accurate method deriving from first principles. Hence, it is guaranteed to be accurate within limits of model, and not show spurious effects of numerical dispersion arising in other techniques like Finite-difference time-domain (FDTD) method.
See also
Eigenmode |
https://en.wikipedia.org/wiki/Phenylmercury%20acetate | Phenylmercuric acetate is an organomercury compound used as a preservative, disinfectant, and antitranspirant.
Properties
Phenylmercuric acetate forms colorless, lustrous crystals, and is soluble in ethanol, benzene, acetic acid, and sparingly in water.
Applications
Phenylmercuric acetate has been used as a preservative in eyedrops and paint, disinfectant, former fungicide in agriculture, and a potential fungicide in leather processing. It kills crabgrass, the seedlings of which are especially vulnerable, but leaves most lawn grasses intact. It exhibits anti-fungal activity against a broad range of ocular pathogenic fungi, with the greatest activity against Fusarium spp, and has been investigated as a potential treatment for keratomycosis.
Phenylmercuric acetate was used for disinfecting mucous membranes, but due to toxicological and ecotoxicological reasons, is no longer used. Phenylmercuric acetate was once used commercially as a catalyst in 3M Tartan brand polyurethane flexible floors, a common flooring used in public buildings, especially in school gymnasiums, in the 1950's through 1970's. In 2006, PMA was discovered to slowly leach from the 3M Tartan flooring in several Idaho public schools and was detectible using analytical methods of air monitoring via NIOSH 6009 Carulite Tubes and the Ohio-Lumex mercury vapor direct-reading analyzer.
Hazards
Contact with phenylmercuric acetate can cause allergic reactions., such as erythema and contact urticaria syndrome. IgE pl |
https://en.wikipedia.org/wiki/Al-Hussein%20Mosque | The al-Hussein Mosque or al-Husayn Mosque, also known as the Mosque of al-Imam al-Husayn () and the Mosque of Sayyidna al-Husayn, is a mosque and mausoleum of Husayn ibn Ali, originally built in 1154, and then later reconstructed in 1874. The mosque is located in Cairo, Egypt, near the Khan El-Khalili bazaar, near-by the famous Al Azhar Mosque, in an area known as Al-Hussain. It is considered to be one of the holiest Islamic sites in Egypt. Some Shia Muslims believe that Husayn's head (ra's mubarak) is buried on the grounds of the mosque where a mausoleum is located today and considered to be what is left of the Fatimid architecture in the building.
History
Fatimid period
According to Fatimid tradition, in the year 985, the 15th Fatimid Caliph, Abu Mansoor Nizar al-Aziz Billah, traced the site of his great-grandfather's head through the office of a contemporary in Baghdad. It remained buried in the Shrine of Husayn's Head, Palestine, for about 250 years, until 1153. It was "rediscovered" in 1091 at a time when Badr al-Jamali, the grand vizier under Caliph al-Mustansir, had just reconquered the region for the Fatimid Caliphate. Upon discovery, he ordered the construction of a new Friday mosque and mashhad (memorial shrine) on the site.
After the 21st Fatimid Imam At-Tayyib Abu'l-Qasim went into seclusion, his uncle, Abd al Majid, occupied the Fatimid Empire's throne. Fearing disrespect and possible traitorous activity, the Majidi-monarch, Al-Zafir, ordered the transfer of |
https://en.wikipedia.org/wiki/Oxalyldiaminopropionic%20acid | Oxalyldiaminopropionic acid (ODAP) is a structural analogue of the neurotransmitter glutamate found in the grass pea Lathyrus sativus. It is the neurotoxin responsible for the motor neuron degeneration syndrome lathyrism.
Sources
ODAP is found in the seeds of the legume L. sativus, a grass pea plant, in the range of .5% w/w. L. sativus can be found in areas of Southern, Central, and Eastern Europe, the Mediterranean Basin, Iraq and Afghanistan as well as areas of Asia and Africa.
History
In some regions, including the Indian subcontinent, Bangladesh, Ethiopia and Nepal, the grass pea has become a staple food item. The plant has a high tolerance of environmental conditions which results in it being the only available food source in times of famine or drought. Following these several month droughts, neurolathyrism epidemics may occur. The last instance of such an epidemic (as of 2013) was in Ethiopia during the 1995-1997 drought during which 2000 people became permanently disabled.
Biological effects
ODAP is an agonist of the ionotropic AMPA glutamate receptor. It is known to cause neurolathyrism in humans, a motor neuron degenerative disease characterized by degeneration of pyramidal-tract neurons in the spinal cord and in the area of the cortex controlling the legs, resulting in lower-body paralysis. There is not one direct explanation as to how ODAP causes neurolathyrism; however, there has been evidence to support a few biological effects. One reason why the mechanism of |
https://en.wikipedia.org/wiki/EGF%20module-containing%20mucin-like%20hormone%20receptor | The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk. There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.
References
External links
G protein-coupled receptors |
https://en.wikipedia.org/wiki/EMR1 | EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.
Function
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.
Clinical significance
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.
See also
EGF module-containing mucin-like hormone receptor
References
External links
GPCR consortium
G protein-coupled receptors |
https://en.wikipedia.org/wiki/EMR2 | EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes. In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. Mice lack the Emr2 gene. This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.
Ligand
Like the related CD97 protein, the fourth EGF-like domain of EMR2 binds chondroitin sulfate B to mediate cell attachment. However, unlike CD97 EMR2 does not interact with the complement regulatory protein, decay accelerating factor CD55, and indicating that these very closely related proteins likely have nonredundant functions.
Signaling
Inositol phosphate (IP3) accumulation assays in overexpressing HEK293 cells have demonstrated coupling of EMR2 to Gα15. EGF-like module-containing mucin-like hormone receptor-like 2 (EMR2) is a |
https://en.wikipedia.org/wiki/EMR3 | EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.
Function
The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.
Ligands
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.
References
External links
GPCR consortium
G protein-coupled receptors |
https://en.wikipedia.org/wiki/Plicamycin | Plicamycin (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces plicatus. It is an RNA synthesis inhibitor. The manufacturer discontinued production in 2000. Several different structures are currently reported in different places all with the same chromomycin core, but with different stereochemistry in the glycoside chain, a 1999 study has re-investigated the compound and proposed a revised structure.
Uses
Plicamycin has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia.
Plicamycin has been tested in chronic myeloid leukemia.
Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor.
One elucidated pathway shows it interacts by cross-binding chromatin GC-rich promoter motifs, thereby inhibiting gene transcription.
References
External links
Mithramycin A from Center for Pharmaceutical Research and Innovation
DNA replication inhibitors |
https://en.wikipedia.org/wiki/List%20of%20Tamworth%20F.C.%20managers | This is a list of managers of Tamworth Football Club.
Statistics
''Information correct as of 3 March 2019. Only competitive matches are counted. Wins, losses and draws are results at the final whistle; the results of penalty shoot-outs are not counted.
References
General
Tamworth F.C. Official Website
Tamworth F.C. Heritage Website
Specific
Managers
Tamworth |
https://en.wikipedia.org/wiki/Kevin%20Eggan | Kevin Eggan (born 1974 in Normal, Illinois) is a Professor of Stem Cell and Regenerative Biology at Harvard University, known for his work in stem cell research (also known as "therapeutic cloning"), and as a spokesperson for stem cell research in the United States. He was a 2006 recipient of a MacArthur Fellowship (sometimes nicknamed the "genius grant"). In 2005, he was named to the MIT Technology Review TR35 as one of the top 35 innovators in the world under the age of 35.
Biography
Background and education
Eggan grew up in Normal, Illinois, the son of Chris and Larry Eggan and one of five children, his father being a math professor at Illinois State University.
After completing his bachelor's degree in microbiology at the University of Illinois, he applied to medical school to become a doctor, but his doubts caused him to defer in favor of a two-year internship with drug company Amgen at the National Institutes of Health. In 1998 he applied to study for a Ph.D. in biology at the Massachusetts Institute of Technology, arriving there shortly after Dolly the Sheep gained worldwide attention as the world's first cloned domestic animal.
Eggan began to explore both this process and also the reasons that cloned animals often appeared to develop abnormally, with organ defects and immunological problems – his first contact with stem cell research. After finishing his PhD in 2002, Eggan split his time between a post-doctoral program with genetics pioneer Rudolf Jaenisch and a c |
https://en.wikipedia.org/wiki/Clinical%20prediction%20rule | A clinical prediction rule or clinical probability assessment specifies how to use medical signs, symptoms, and other findings to estimate the probability of a specific disease or clinical outcome.
Physicians have difficulty in estimated risks of diseases; frequently erring towards overestimation, perhaps due to cognitive biases such as base rate fallacy in which the risk of an adverse outcome is exaggerated.
Methods
In a prediction rule study, investigators identify a consecutive group of patients who are suspected of having a specific disease or outcome. The investigators then obtain a standard set of clinical observations on each patient and a test or clinical follow-up to define the true state of the patient. They then use statistical methods to identify the best clinical predictors of the patient's true state. The probability of disease will depend on the patient's key clinical predictors. Published methodological standards specify good practices for developing a clinical prediction rule.
A survey of methods concluded "the majority of prediction studies in high impact journals do not follow current methodological recommendations, limiting their reliability and applicability", confirming earlier findings from the diabetic literature
Effect on health outcomes
Few prediction rules have had the consequences of their usage by physicians quantified.
When studied, the impact of providing the information alone (for example, providing the calculated probability of disease) |
https://en.wikipedia.org/wiki/Harry%20V.%20Roberts | Harry V. Roberts (1923–2004), American statistician, was a distinguished teacher and a pioneer in looking at the applications of Bayesian statistics to business decision making and in Total Quality Management.
Roberts began teaching at the University of Chicago Graduate School of Business in 1949 as an instructor of statistics. He was promoted to assistant professor in 1951. He earned his Ph.D. from the University of Chicago in 1955, and was appointed associate professor. He was made full professor in 1959, and was named Sigmund E. Edelstone Professor of Statistics and Quality Management in 1991. In 1997, Roberts was awarded the Norman Maclean Faculty Award from the University of Chicago for his contributions to teaching and to the student experience on campus. In recognition of his career achievements, the Chicago chapter of the American Statistical Association created the Harry V. Roberts Statistical Advocate Award, first given in January 2002.
His varied research interests also included interactive computing; time series analysis; the relation between statistical theory and practical decision making; survey methodology and practice; and productivity and quality improvement.
Roberts was the co-author of many influential publications, including two groundbreaking books: Basic Methods of Marketing Research (with James Lorie) and the textbook, Statistics: A New Approach (with W. Allen Wallis). He also co-authored an early work on the random walk hypothesis of stock market |
https://en.wikipedia.org/wiki/NUTS%20statistical%20regions%20of%20Austria | The Nomenclature of Territorial Units for Statistics (NUTS) is a geocode standard for referencing the subdivisions of Austria for statistical purposes. The standard is developed and regulated by the European Union. The NUTS standard is instrumental in delivering the European Union's Structural Funds. The NUTS code for Austria is AT and a hierarchy of three levels is established by Eurostat. Below these is a further levels of geographic organisation - the local administrative unit (LAU). In Austria, the LAU 2 is municipalities.
Overall
NUTS Levels
Local administrative units
Below the NUTS levels, the two LAU (Local Administrative Units) levels are:
The LAU codes of Austria can be downloaded here: NUTS codes
NUTS 3 definitions
AT1 Eastern Austria (Ostösterreich)
AT11 Burgenland
AT111 Mittelburgenland (Bezirk Oberpullendorf)
AT112 Nordburgenland (Eisenstadt, Rust, Bezirk Eisenstadt-Umgebung, Bezirk Mattersburg, Bezirk Neusiedl am See)
AT113 Südburgenland (Bezirk Güssing, Bezirk Jennersdorf, Bezirk Oberwart)
AT12 Lower Austria (Niederösterreich)
AT121 Mostviertel-Eisenwurzen (Waidhofen an der Ybbs, Bezirk Amstetten, Bezirk Melk, Bezirk Scheibbs)
AT122 Niederösterreich-Süd (Wiener Neustadt, Bezirk Lilienfeld, Bezirk Neunkirchen, Bezirk Wiener Neustadt-Land)
AT123 Sankt Pölten (Sankt Pölten, Bezirk Sankt Pölten-Land)
AT124 Waldviertel (Krems, Bezirk Gmünd, Bezirk Horn, Bezirk Krems-Land, Bezirk Waidhofen an der Thaya, Bezirk Zwettl)
AT125 Weinviertel (Bezirk Hol |
https://en.wikipedia.org/wiki/Lorna%20Wighton | Lorna Wighton (born June 2, 1958 in Toronto, Ontario) is a Canadian former ice dancer. With partner John Dowding, she won three gold medals at the Canadian Figure Skating Championships and finished sixth at the 1980 Winter Olympics.
Results
(with John Dowding)
References
1958 births
Canadian female ice dancers
Figure skaters at the 1980 Winter Olympics
Living people
Olympic figure skaters for Canada
Figure skaters from Toronto |
https://en.wikipedia.org/wiki/John%20Dowding%20%28figure%20skater%29 | John Dowding (born April 27, 1957 in Oakville, Ontario) is a Canadian former ice dancer. With partner Lorna Wighton, he won three gold medals at the Canadian Figure Skating Championships and finished sixth at the 1980 Winter Olympics.
Currently, Mr. Dowding resides in Fresno, California and is the owner of Champion Window Coverings.
Results
(with Lorna Wighton)
Navigation
References
1957 births
Canadian male ice dancers
Figure skaters at the 1980 Winter Olympics
Olympic figure skaters for Canada
Living people
20th-century Canadian people |
https://en.wikipedia.org/wiki/Amylacea | Amylacea may refer to:
A Latinate biological word meaning starchy
Corpora amylacea, dense accumulations of calcified proteinaceous material in the ducts of prostates in older men |
https://en.wikipedia.org/wiki/Climate%20of%20Iceland | The climate of Iceland is subpolar oceanic (Köppen climate classification Cfc) near the southern coastal area and tundra (Köppen ET) inland in the highlands. The island lies in the path of the North Atlantic Current, which makes its climate more temperate than would be expected for its latitude just south of the Arctic Circle. This effect is aided by the Irminger Current, which also helps to moderate the island's temperature. The weather in Iceland is notoriously variable.
The aurora borealis is often visible at night during the winter. The midnight sun can be experienced in summer on the island of Grímsey off the north coast; the remainder of the country, since it lies just south of the polar circle, experiences a twilight period during which the sun sets briefly, but still has around two weeks of continuous daylight during the summer.
Seasons
Winter
The Icelandic winter is relatively mild for its latitude, owing to maritime influence and proximity to the warm currents of the North Atlantic Gyre. The southerly lowlands of the island average around in winter, while the north averages around . The lowest temperatures in the northern part of the island range from around . The lowest temperature on record is .
Summer
The average July temperature in the southern part of the island is . Warm summer days can reach . The highest temperature recorded was in the Eastern fjords in 1939. Annual average sunshine hours in Reykjavík are around 1300, which is similar to towns in Scotl |
https://en.wikipedia.org/wiki/Vantieghems%20theorem | In number theory, Vantieghems theorem is a primality criterion. It states that a natural number n≥3 is prime if and only if
Similarly, n is prime, if and only if the following congruence for polynomials in X holds:
or:
Example
Let n=7 forming the product 1*3*7*15*31*63 = 615195. 615195 = 7 mod 127 and so 7 is prime
Let n=9 forming the product 1*3*7*15*31*63*127*255 = 19923090075. 19923090075 = 301 mod 511 and so 9 is composite
References
. An article with proof and generalizations.
Factorial and binomial topics
Modular arithmetic
Theorems about prime numbers |
https://en.wikipedia.org/wiki/Hugo%20Machado | Hugo Miguel Alves Machado (born 4 July 1982 in Lisbon) is a Portuguese footballer who plays for Clube Oriental de Lisboa as an attacking midfielder.
Club statistics
References
External links
Barreirense official profile
Persian League stats
1982 births
Living people
Portuguese men's footballers
Footballers from Lisbon
Men's association football midfielders
Primeira Liga players
Liga Portugal 2 players
Segunda Divisão players
Sporting CP B players
C.F. Estrela da Amadora players
F.C. Barreirense players
Associação Naval 1º de Maio players
Clube Oriental de Lisboa players
Real S.C. players
GS Loures players
C.D. Cova da Piedade players
Cypriot First Division players
Apollon Limassol FC players
Olympiakos Nicosia players
Alki Larnaca FC players
Azerbaijan Premier League players
FK Standard Sumgayit players
Persian Gulf Pro League players
Zob Ahan Esfahan F.C. players
Sanat Naft Abadan F.C. players
I-League players
Churchill Brothers FC Goa players
Football League (Greece) players
Athens Kallithea F.C. players
OFI Crete F.C. players
Portuguese expatriate men's footballers
Expatriate men's footballers in Cyprus
Expatriate men's footballers in Azerbaijan
Expatriate men's footballers in Iran
Expatriate men's footballers in India
Expatriate men's footballers in Greece
Portuguese expatriate sportspeople in Cyprus
Portuguese expatriate sportspeople in Azerbaijan
Portuguese expatriate sportspeople in Iran
Portuguese expatriate sportspeople in India
Portuguese expatriate sportspeop |
https://en.wikipedia.org/wiki/Geibeltbad%20Pirna | The Geibeltbad Pirna is a public bath and water sport facility in Pirna near Dresden, Saxony in Germany. Finished under the Nazis on June 20, 1937, it is one of the largest baths in the world. Completely paid by the Anna Marie Geibelt Foundation (House of Wettin Royalists) and constructed on a her mud area, between April - June 20, 1937 (three months construction only). The foundation got it's inspiration from the International Hygiene Exhibition, were the public bath in that new form had been invented. The 20,000 square metre site was renovated and upgraded in 2001-02 to include an indoor swimming pool, wellness centre and other facilities. From 1937 to 1990 Geibeltbad was a venue for the German swimming championships as well as a training site. In 2006, the bath welcomed 233,588 visitors.
Location
Pirna is located in a wooded valley between Viehleite and Kohlberg and can be reached by taking a thirty-minute train ride from Dresden on the Dresden S-Bahn "S1" followed by a ten-minute bus trip on the Neundorf (Pirna) "N-Line" to the Geibeltbad stop.
Structure after modification 1999 since 2002
Outdoor pools
There is a open air pool, a non-swimmer pool (250 m ³), a 10 m tower with 1 m, 3 m and 5 m stages with a diving pool with 850 m ³ capacity. In addition in the east part and western part are paddling pools for children.
In addition there are cabin wings, which extend between old and new entrances in the style of the 1930s. Several playgrounds are available, such as "Ga |
https://en.wikipedia.org/wiki/PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1 gene. The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein.
Function
PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller–Dieker syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acetylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
According to one study, PAFAH1B1 interacts with VLDLR receptor activated by reelin.
Genomics
The gene is located at chromosome 17p13.3 on the Watson (plus) strand. The gene is 91,953 bases in length and encodes a protein of 410 amino acids (predicted molecular weight 46.638 kiloDaltons).
Interactions
PAFAH1B1 has been shown to interact with DYNC1H1, CLIP1, NDEL1, NDE1, PAFAH1B3, PAFAH1B2, NUDC, TUBA1A and Doublecortin.
See also
platelet-activating factor
PAFAH1B2
PAFAH1B3
References
Further reading
External links
GeneReview/NIH/UW entry on LIS1-Ass |
https://en.wikipedia.org/wiki/John%20Hilton%20Grace | John Hilton Grace FRS (21 May 1873 – 4 March 1958) was a British mathematician. The Grace–Walsh–Szegő theorem is named in part after him.
Early life
He was born in Halewood, near Liverpool, the eldest of the six children of farmer William Grace and Elizabeth Hilton. He was educated at the village school and the Liverpool Institute. From there in 1892 he went up to Peterhouse, Cambridge to study mathematics.
His nephew, his younger sister's son, was the animal geneticist, Alan Robertson FRS.
Career
He was made a Fellow of Peterhouse in 1897 and became a Lecturer of Mathematics at Peterhouse and Pembroke colleges. An example of his work was his 1902 paper on The Zeros of a Polynomial. In 1903 he collaborated with Alfred Young on their book Algebra of Invariants.
He was elected a Fellow of the Royal Society in 1908.
He spent 1916–1917 as Visiting Professor in Lahore and deputised for Professor MacDonald at Aberdeen University during the latter part of the war.
In 1922 a breakdown in health forced his retirement from academic life and he spent the next part of his life in Norfolk.
He died in Huntingdon in 1958 and was buried in the family grave at St. Nicholas Church, Halewood.
Theorem on zeros of a polynomial
If
,
are two polynomials that satisfy the apolarity condition, i.e. , then every neighbourhood that includes all zeros of one polynomial also includes at least one zero of the other.
Corollary
Let and be defined as in the above theorem. If the zeros of both poly |
https://en.wikipedia.org/wiki/Aleksandr%20Karshakevich | Aleksandr Vladimirovich Karshakevich (; , born 6 April 1959 in Ashmyany, Hrodna Voblast) is a former Soviet/Belarusian handball player who competed in the 1980 Summer Olympics and in the 1988 Summer Olympics.
In 1980, he won the silver medal with the Soviet team. He played four matches including the final and scored 13 goals.
Eight years later he won the gold medal with the Soviet team. He played five matches including the final and scored twenty goals.
External links
1959 births
Living people
People from Ashmyany
Soviet male handball players
Belarusian male handball players
Handball players at the 1980 Summer Olympics
Handball players at the 1988 Summer Olympics
Olympic handball players for the Soviet Union
Olympic gold medalists for the Soviet Union
Olympic silver medalists for the Soviet Union
Olympic medalists in handball
Medalists at the 1988 Summer Olympics
Medalists at the 1980 Summer Olympics
Sportspeople from Grodno Region
Friendship Games medalists in handball
Honoured Masters of Sport of the USSR |
https://en.wikipedia.org/wiki/Aristaless%20related%20homeobox | Aristaless related homeobox is a protein that in humans is encoded by the ARX gene.
Function
This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is involved in CNS and pancreas development.
Clinical significance
Mutation in the ARX gene are associated with X-linked intellectual disability, lissencephaly, as well as hypoglycemia (in mice).
See also
homeobox
References
Further reading
External links
Transcription factors |
https://en.wikipedia.org/wiki/Fukutin | Fukutin is a eukaryotic protein necessary for the maintenance of muscle integrity, cortical histogenesis, and normal ocular development. Mutations in the fukutin gene have been shown to result in Fukuyama congenital muscular dystrophy (FCMD) characterised by brain malformation - one of the most common autosomal-recessive disorders in Japan. In humans this protein is encoded by the FCMD gene (also named FKTN), located on chromosome 9q31. Human fukutin exhibits a length of 461 amino acids and a predicted molecular mass of 53.7 kDa.
Function
Although its function is mostly unknown, fukutin is a putative transmembrane protein that is ubiquitously expressed, although at higher levels in skeletal muscle, heart and brain. It is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of α-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Fukutin is expressed in the mammalian retina and is located in the Golgi complex of retinal neurons.
Clinical significance
Defects in this gene are a cause of Fukuyama congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X).
See also
Fukutin-related protein
References
Further reading
External links
GeneReviews/NCBI/NIH/UW entry on Congenital Muscular Dystrophy Overview
LOVD mutation database: FKTN |
https://en.wikipedia.org/wiki/Serb%20People%27s%20Radical%20Party | The Serbian People's Radical Party (Serbian: Српска народна радикална странка, Srpska narodna radikalna stranka) was an ethnic Serb political party in Austria-Hungary. It was founded in 1887 in Novi Sad, but later disbanded in 1919. The party was a more radical fork of the Serbian People's Liberal Party, and also a sister party of the People's Radical Party in Serbia.
It was one of the founders of the Serbo-Croat coalition (1905) that governed the Kingdom of Croatia-Slavonia, but it left the Coalition soon afterwards.
In 1918, it had two representatives in the National Council of Slovenes, Croats and Serbs.
References
Sources
Political parties in Austria-Hungary
History of the Serbs of Croatia
Austro-Hungarian Serbs
Ethnic organizations based in Austria-Hungary
Radical parties |
https://en.wikipedia.org/wiki/Fukutin-related%20protein | Fukutin-related protein (FKRP) is also known as FKRP_HUMAN, LGMD2I, MDC1C, MDDGA5, MDDGB5, and MDDGC5. FKRP can be located in the brain, cardiac muscle and skeletal muscle, and in cells it is found in the Golgi apparatus. Fukutin is expressed in the mammalian retina and is located in the Golgi complex of retinal neurons.
The genomic location of the FKRP gene is on chromosome 19. FKRP is a ribitol-5-phosphate (enzyme) glycosyltranferase, which means this enzyme helps create glycosidic linkages to an acceptor. In glycosylation of α-dystroglycan (sugar chain) it adds a ribitol-5-phosphate onto the M3 core O-mannosylation of α-dystroglycan to create O-linked mannosylation. Without this linkage α-dystroglycan will not function properly, this can cause issues with the cytoskeleton, and extracellular matrix. In skeletal muscles the α-dystroglycan helps stabilize and protect muscle fibers, in the brain it directs movement of nerve cells. This could be caused by mutations that binds ribitol-5-phosphate to the α-dystroglycan incorrectly. These mutations have been found to be associated with congenital muscular dystrophy, dystroglycanopathies, and Walker-Warburg syndrome. The severity of these diseases are correlated to the amount of mutations occurring. Possible therapy options for FKRP mutations include small molecules, gene delivery, and cell therapy.
See also
Fukutin
References
External links
GeneReviews/NCBI/NIH/UW entry on Congenital Muscular Dystrophy Overview
LOVD muta |
https://en.wikipedia.org/wiki/Naphthalocyanine | Naphthalocyanine is a cross-shaped organic molecule consisting of 48 carbon, 8 nitrogen and 26 hydrogen atoms, it is a derivative of phthalocyanine. IBM Research labs used it for developing single-molecule logic switches and visualizing charge distribution in a single molecule.
Naphthalocyanine derivatives have a potential use in photodynamic cancer treatment.
References
External links
Timmer, J. (2007) Storing data in molecules: shifting atoms and flipping bits, ars technica online [accessed 8 September 2007]
Phthalocyanines
Molecular electronics |
https://en.wikipedia.org/wiki/Gladna | The Gladna or Râul is a left tributary of the river Bega in Romania. It discharges into the Bega in Leucușești. Its length is and its basin size is . The Surduc Dam is built on the Gladna.
References
Rivers of Romania
Rivers of Timiș County |
https://en.wikipedia.org/wiki/Llanos%20de%20Challe%20National%20Park | Llanos de Challe National Park is located on the Pacific coast of the Atacama Region, Chile. The park's mountains are moistened by the Camanchaca, creating a fog and mist-fed ecosystem called lomas (Spanish for "hills"). The park is one of the southernmost locations of the lomas which are scattered along the coastal desert from northern Chile to northern Peru. The highest elevation in the park is Cerro Negro at 950 m.
This fragile coastal desert ecosystem is habitat for rare and beautiful plants species, including the threatened Leontochir ovallei, known locally as Garra de León. In addition to, cactus are abundant in the park.
The park is one of the best place for contemplating the natural phenomenon known as desierto florido (desert bloom), which occurs occasionally as a consequence of El Niño-Southern Oscillation.
The park has the largest population of guanacos in the Atacama Region. Park's seashore and surrounding area feature unspoiled white sand beaches and a coastal wetland, which shelters common moorhens, red-gartered coots, black-necked swans and flamingos.
References
Parque Nacional Llanos de Challe
Protected areas of Atacama Region
National parks of Chile
Coasts of Atacama Region
Protected areas established in 1994 |
https://en.wikipedia.org/wiki/Orexin%20receptor | The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin. There are two variants, OX1 and OX2, each encoded by a different gene (, ).
Both orexin receptors exhibit a similar pharmacology – the 2 orexin peptides, orexin-A and orexin-B, bind to both receptors and, in each case, agonist binding results in an increase in intracellular calcium levels. However, orexin-B shows a 5- to 10-fold selectivity for orexin receptor type 2, whilst orexin-A is equipotent at both receptors.
Several orexin receptor antagonists are in development for potential use in sleep disorders. The first of these, suvorexant, has been on the market in the United States since 2015. There were two orexin agonists under development .
Ligands
Several drugs acting on the orexin system are under development, either orexin agonists for the treatment of conditions such as narcolepsy, or orexin antagonists for insomnia. In August 2015, Nagahara et al. published their work in synthesizing the first HCRT/OX2R agonist, compound 26, with good potency and selectivity.
No neuropeptide agonists are yet available, although synthetic orexin-A polypeptide has been made available as a nasal spray and tested on monkeys. One non-peptide antagonist is currently available in the U.S., Merck's suvorexant (Belsomra), two additional agents are in development: SB-649,868 by GlaxoSmithKline, for sleep disorders, and ACT-462206, currently in human clinical |
https://en.wikipedia.org/wiki/Urotensin-II%20receptor | The urotensin-2 receptor (UR-II-R) also known as GPR14 is a class A rhodopsin family G protein coupled-receptor (GPCR) that is 386 amino acids long which binds primarily to the neuropeptide urotensin II.[1] The receptor quickly rose to prominence when it was found that when activated by urotensin II it induced the most potent vasoconstriction effect ever seen. While the precise function of the urotensin II receptor is not fully known it has been linked to cardiovascular effects, stress, and REM sleep.
Ligands
There are two known endogenous agonists for the urotensin II receptor. One is urotensin II whose mRNA is found in a variety of tissues including the brain and also blood vessels. It is a potent vasoconstrictor and can increase REM cycles. The other is urotensin II-Related Peptide (URP) which is found in a variety of tissues as well although at less concentrations then urotensin II. The one exception is in human reproductive tissue where the levels of URP are much higher than urotensin II.
Cellular Pathway
Urotensin II Receptor interacts with the G Protein whose alpha subunit is Gαq11 which is mainly involved in activating Protein Kinase C (PKC). This then activates phospholipase C which increases the intercellular amount of calcium through the activation of IP3 which is an intracellular molecule that acts as secondary messenger. IP3 will then release calcium which then activates PKC.
When the urotensin II receptor is activated it also promotes beta arrestin trans |
https://en.wikipedia.org/wiki/Neuromedin%20U%20receptor | The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S. There are two subtypes of the neuromedin U receptor, each encoded by a separate gene (, ).
Selective Ligands
Neuromedin U is an agonist at both the NMU1 and NMU2 subtypes, while neuromedin S is selective for NMU2, and is a more potent agonist at this subtype than neuromedin U. Several other peptide and non-peptide ligands are also available for the NMU receptors.
Agonists
Non-selective
Neuromedin U
non-peptide NMU modulators
NMU2 selective
Neuromedin S
Antagonists
NMU2 selective
R-PSOP
References
External links
G protein-coupled receptors |
https://en.wikipedia.org/wiki/Voltage-dependent%20anion%20channel | Voltage-dependent anion channels, or mitochondrial porins, are a class of porin ion channel located on the outer mitochondrial membrane. There is debate as to whether or not this channel is expressed in the cell surface membrane.
This major protein of the outer mitochondrial membrane of eukaryotes forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30–40 mV. VDAC facilitates the exchange of ions and molecules between mitochondria and cytosol and is regulated by the interactions with other proteins and small molecules.
Structure
This protein contains about 280 amino acids and forms a beta barrel which spans the mitochondrial outer membrane.
Since its discovery in 1976, extensive function and structure analysis of VDAC proteins has been conducted. A prominent feature of the pore emerged: when reconstituted into planar lipid bilayers, there is a voltage-dependent switch between an anion-selective high-conductance state with high metabolite flux and a cation-selective low-conductance state with limited passage of metabolites.
More than 30 years after its initial discovery, in 2008, three independent structural projects of VDAC-1 were completed. The first was solved by multi-dimensional NMR spectroscopy. The second applied a hybrid approach using crystallographic data. The t |
https://en.wikipedia.org/wiki/Nucleoporin | Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm. Nuclear pores enable the passive and facilitated transport of molecules across the nuclear envelope. Nucleoporins, a family of around 30 proteins, are the main components of the nuclear pore complex in eukaryotic cells. Nucleoporin 62 is the most abundant member of this family. Nucleoporins are able to transport molecules across the nuclear envelope at a very high rate. A single NPC is able to transport 60,000 protein molecules across the nuclear envelope every minute.
Structure
Nucleoporins aggregate to form a nuclear pore complex, an octagonal ring that traverses the nuclear envelope. The ring consists of eight scaffold sub-complexes, with two structural layers of COPII-like coating sandwiching some proteins that line the pore. From the cytoplasm to the nucleoplasm, the three layers of the ring complex is named the cytoplasm, inner pore, and nucleoplasm rings respectively. Different sets of proteins associate on either ring, and some transmembrane proteins anchor the assembly to the lipid bilayer.
In a scaffold subcomplex, both the cytoplasm and the nucleoplasm rings are made up of Y-complexes, a protein complex bu |
https://en.wikipedia.org/wiki/Ceftezole | Ceftezole (or ceftezol) is a semisynthetic first-generation cephalosporin antibiotic.
Ceftezole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Ceftezole is having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1H-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. It is a cephalosporin and a member of thiadiazoles.
References
Note
External links
Cephalosporin antibiotics
Enantiopure drugs
Thiadiazoles
Tetrazoles |
https://en.wikipedia.org/wiki/Cephaloridine | Cephaloridine (or cefaloridine) is a first-generation semisynthetic derivative of antibiotic cephalosporin C. It is a Beta lactam antibiotic, like penicillin. Its chemical structure contains 3 cephems, 4 carboxyl groups and three pyridinium methyl groups.
Cephaloridine is mainly used in veterinary practice. It is unique among cephalosporins in that it exists as a zwitterion.
History
Since the discovery of cephalosporins P, N and C in 1948 there have been many studies describing the antibiotic action of cephalosporins and the possibility to synthesize derivatives. Hydrolysis of cephalosporin C, isolation of 7-aminocephalosporanic acid and the addition of side chains opened the possibility to produce various semi-synthetic cephalosporins. In 1962, cephalothin and cephaloridine were introduced.
Cephaloridine was briefly popular because it tolerated intramuscularly and attained higher and more sustained levels in blood than cephalothin. However, it binds to proteins to a much lesser extent than cephalothin. Because it is also poorly absorbed after oral administration the use of this drug for humans declined rapidly, especially since the second generation of cephalosporins was introduced in the 1970s. Today, it is more commonly used in veterinary practice to treat mild to severe bacterial infections caused by penicillin resistant and penicillin sensitive Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Streptococcus pneumoniae, Bacillus subtilis, Klebsiella, Clo |
https://en.wikipedia.org/wiki/Another%20Animal | Another Animal was an American rock supergroup formed by members of Godsmack, Ugly Kid Joe, and Dropbox.
History
During the writing sessions of IV by Godsmack, lead singer Sully Erna encountered writer's block so Tony Rombola, Shannon Larkin, and Robbie Merrill went to the studio and recorded music. After writing almost 40 songs, only 14 were used (two being bonus songs). The left-over songs were then recycled by the members after they recruited Whitfield Crane of Ugly Kid Joe and Another Animal was born. Soon joining the band was friend and former Godsmack and Dropbox guitarist Lee Richards. The band released its self titled debut album in 2007 and first single "Broken Again" reached No. 8 on the U.S. Billboard Hot Mainstream Rock Tracks chart. To support their debut album, Another Animal opened for Alter Bridge on tour in late 2007.
Another Animal is part of the stable of artists who have recorded at Rocking Horse Studio in Pittsfield, New Hampshire.
Another Animal released a single titled "Fall of Rome". The track is produced by Dave Fortman. Drummer Shannon Larkin mentioned that if the single is a success they will make a new album, a follow-up to their self-titled debut album of 2007. He said "If the song does well enough at radio, we will tour in the fall and make a new record as well." Obviously the band had not reached its goal.
Members
Whitfield Crane – lead vocals (Ugly Kid Joe & Medication)
Tony Rombola – lead guitar, backing vocals (Godsmack)
Robbie Merril |
https://en.wikipedia.org/wiki/TTS%20Tren%C4%8D%C3%ADn | TTS Trenčín was a Slovak football club, playing in the town of Trenčín.
History
The club was founded in 1904 as Trencsény Torna Egyesület (TTE).
TTS Trenčín first played in the top flight of Slovakia during World War II, when Slovak and Czech competitions were separated. During the sixties the team returned to the top flight, under new name Jednota Trenčín. The best place was in 1963 when the club became second after Dukla Prague. In 1966 and 1968 the team participated in the Mitropa Cup. In 1972 the club was relegated.
After three seasons Jednota returned and played in the top flight until 1980. After this the team could never return and was even relegated to the third level in 1981. However Jednota was promoted immediately and changed the name back to TTS. In 1985 TTS was relegated to the third level and did not manage to come back. During the last Czechoslovak season in 1992/93 the team ended one place above newly founded Ozeta Dukla Trenčin. Afterwards both clubs merged.
Honours
Domestic
Czechoslovak First League
Runners-up (1): 1962–63
Third Place (1): 1967–68
Slovak Cup
Winners (1): 1978
European
Mitropa Cup
Runners-up (1): 1966
Notable players
Had international caps for their respective countries. Players whose name is listed in bold represented their countries while playing for TTS.
Milan Albrecht
Pavol Bencz
Ivan Bilský
Ladislav Józsa
Ján Kapko
Bozhin Laskov
Vojtech Masný
Emil Pažický
Miroslav Siva
Anton Švajlen
Referenc |
https://en.wikipedia.org/wiki/Prokineticin%20receptor | The prokineticin receptor is a G protein-coupled receptor which binds the peptide hormone prokineticin. There are two variants each encoded by a different gene (PROKR1, PROKR2). These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis.
References
External links
G protein-coupled receptors |
https://en.wikipedia.org/wiki/Prokineticin | Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.
Recently, prokineticins have been recognized in humans and other vertebrates. They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception. Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.
Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.
See also
Prokineticin receptor
References
External links
Intestinal hormones |
https://en.wikipedia.org/wiki/Free%20fatty%20acid%20receptor | Free fatty acid receptors (FFARs) are G-protein coupled receptors (GPRs). GPRs (also termed seven-(pass)-transmembrane domain receptors) are a large protein family of receptors. They reside on their parent cells' surface membranes, bind any one of a specific set of ligands that they recognize, and thereby are activated to elicit certain types of responses in their parent cells. Humans have >800 different types of GPCR receptors. The FFARs are GPCR receptors that bind and thereby are activated by particular fatty acids. In general, these binding/activating fatty acids are straight-chain fatty acids consisting of a carboxylic acid residue, i.e., -COOH, attached to aliphatic chains, i.e. carbon atom chains of varying lengths and bound to 1, 2 or 3 hydrogens (CH1, CH2, or CH3). For example, propionic acid is short-chain fatty acid consisting of 3 carbons (C's), CH3-CH2-COOH, and docosahexaenoic acid is long chain polyunsaturated fatty acid consisting of 22 C's and six double bonds (notated as "="): CH3-CH2-CH1=CH1-CH2-CH1=CH1-CH2-CH1=CH1-CH2-CH1=CH1-CH2-CH1=CH1-CH2-CH1=CH1-CH2-CH2-COOH.
Currently, four FFARs are recognized: FFAR1, also termed GPR40; FFAR2, also termed GPR43; FFAR3, also termed GPR41; and FFAR4, also termed GPR120. The human FFAR1, FFAR2,, and FFAR3 genes are located adjacent to each other on the long (i.e., "q") arm of chromosome 19 at position 23.33 (notated as 19q23.33). This location also includes the GPR42 gene which appears to be a segmental duplication o |
https://en.wikipedia.org/wiki/Joy%20Jobbins | Joy Edna Jobbins (5 September 1927 – 7 August 2023) was an Australian writer and marketing executive. She was the head of advertising for The Australian Wool Board and authored the book "Shoestring: a memoir".
Biography
Joy Edna Jobbins was born in Sydney on 5 September 1927. Her father was cinesound cameraman George Malcolm, a pioneer in the Australian film industry; her brother, Ken Malcolm, was also in the film industry, working variously as a sound recordist and editor.
Jobbins went to Bondi Public School, and later studied art at the East Sydney Tech College.
In 1950, she went to work at Anthony Horden's Department Store where she met, and later married Henry Edward Jobbins.
Jobbins worked as a script supervisor on the propaganda film "A Yank Down Under", about R&R leave in Sydney during World War II.
Jobbins subsequently modelled swim suits for Coles of California Swimwear (a New Zealand Company).
After she married, she moved to Eltham, Victoria where she went to work at Carden's Advertising, working on campaigns for Terylene, House of Leroy. Later she left and joined Ralph Blunden's agency where she took control of the Australian Wool Board account working in collaboration with models, photographers and illustrators such as Maggie Tabberer, Henry Talbot, Helmut Newton, Patrick Russell, Des O'Brien, Barbara Robertson and others.
In 1959, she played an important role in the inaugural Australian Fashion Awards.
Jobbins subsequently left Blunden Advertising and wor |
https://en.wikipedia.org/wiki/Super%20Conserved%20Receptor%20Expressed%20in%20Brain | The Super Conserved Receptor Expressed in Brain (SREB) family are a group of related G-protein coupled receptors. Since no endogenous ligands have yet been identified for these receptors, they are classified as orphan receptors. Receptors within the group include SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173).
References
External links
IUPHAR GPCR Database - GPR27 (previously SREB1)
IUPHAR GPCR Database - GPR85 (previously SREB2)
IUPHAR GPCR Database - GPR173 (previously SREB3)
G protein-coupled receptors |
https://en.wikipedia.org/wiki/Platelet-activating%20factor%20receptor | The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. It is encoded in the human by the PTAFR gene.
The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM] Its pathogenetic role in chronic kidney failure has also been reported recently.
Ligands
Agonists
Platelet activating factor
Antagonists
Apafant (WEB-2086)
Israpafant (Y-24180)
Lexipafant
Rupatadine
References
Further reading
External links
G protein-coupled receptors |
https://en.wikipedia.org/wiki/H22 | H22 may refer to:
H22 engine, an automobile engine from Honda
British NVC community H22, a type of heath community in the British National Vegetation Classification
Highway H22 (Ukraine)
, a Royal Navy D-class destroyer
, a Royal Navy H-class submarine
Horikawa H-22, a Japanese trainer glider |
https://en.wikipedia.org/wiki/Tarna%20Mare%20%28river%29 | The Tarna Mare is a right tributary of the river Bătarci in Romania. It flows into the Bătarci near Șirlău. Its length is and its basin size is .
References
Rivers of Romania
Rivers of Satu Mare County |
https://en.wikipedia.org/wiki/Fastpacking | Fastpacking is a combination of trail running and ultralight backpacking: "hiking the ups, jogging the flats, and running the downs," depending on the gradient, because of the weight carried. Participants carry a light pack with essential supplies, including a sleeping bag and tent, or similar form of shelter, if mountain huts or other accommodation is not available. The weight carried will vary but fastpackers aim at no more than and some achieve less than . This activity may be undertaken either unsupported, self-supported, or supported. "Unsupported fastpackers make no use of outside assistance along the route", while self-supported fastpackers will leave caches of supplies along the intended route.
Fastpacking involves covering a considerable distance over several days with a pack, which requires both mental and physical strength. Established, well-traveled long distance trails are used because "with minimal extra food and clothing, getting stuck in the backcountry for an extended period of time can quickly become a dangerous proposition".
Routes
Fastpacking makes use of long distance trails including: in the United Kingdom the South Downs Way, Wainwright's Coast to Coast Walk and the West Highland Way; in Europe the Tour du Mont Blanc, the "Alta Via 1" in the Dolomites, and the Alpine Pass Route; in the US the John Muir Trail in California and the Appalachian trail. In New Zealand world-famous routes such as the Milford, Routeburn, and Abel Tasman Tracks that take hi |
https://en.wikipedia.org/wiki/Abaga%20Falls | Abaga Falls is a waterfall and ecosystem located approximately 15 km southwest of Iligan City on the island of Mindanao, Philippines, specifically in barangay Abaga, Baloi municipality, Lanao del Norte. The height of Abaga Falls is approximately twice that of the more famous Maria Cristina Falls also located within the proximity of Iligan City (in barangay Maria Cristina, Baloi municipality). Unlike Maria Cristina Falls, however, which is fed by the Agus river, the water source of Abaga Falls are several underground springs which flow into the top of Abaga Falls via several tributaries.
Also unlike the more popular Maria Cristina Falls, human access to Abaga Falls is severely limited due to a current lack of regularly maintained roads as well as the fact that a moderate amount of walking is required to reach the base of the falls. This level of isolation has not protected the ecosystem from damage due to deforestation and over-hunting.
The name may have been derived from the Cebuano term "abaga" which means "shoulder", possibly relating to the shape and height of the cliff.
Flora and fauna
There are a number of interesting animals that inhabit the area in and around Abaga Falls. The most notable include; the endangered Philippine eagle (Pithecophaga jefferyi) also commonly known as the "monkey-eating eagle", the rufous hornbill (Buceros hydrocorax), the endangered giant golden-crowned flying fox (Acerodon jubatus) which can only be found in the Philippines, and the Philipp |
https://en.wikipedia.org/wiki/GRIA3 | Glutamate receptor 3 is a protein that in humans is encoded by the GRIA3 gene.
Function
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternative splicing at this locus results in several different isoforms which may vary in their signal transduction properties.
Genome studies have uncovered a tentative link between defective GRIA3 variants and a highly elevated risk of schizophrenia.
Interactions
GRIA3 has been shown to interact with GRIP1 and PICK1.
RNA editing
Several ion channels and neurotransmitters receptors pre-mRNA as substrates for ADARs. This includes 5 subunits of the glutamate receptor: ionotropic AMPA glutamate receptor subunits (GluA2, GluA3, GluA4) and kainate receptor subunits (GluK1, GluK2). Glutamate gated ion channels are made up of four subunits per channel with each subunit contributing to the pore loop structure. The pore loop structure is related to that found in K+ channels (e.g., human Kv1.1 channel). The human Kv1.1 channel pre mRNA is also subject t |
https://en.wikipedia.org/wiki/Terzaghi%27s%20principle | Terzaghi's Principle states that when stress is applied to a porous material, it is opposed by the fluid pressure filling the pores in the material.
Karl von Terzaghi introduced the idea in a series of papers in the 1920s based on his examination of building consolidation on soil. The principle states that all quantifiable changes in stress to a porous medium are a direct result of a change in effective stress. The effective stress, , is related to total stress, , and the pore pressure, , by
,
where is the identity matrix. The negative sign is there because the pore pressure serves to lessen the volume-changing stress; physically this is because there is fluid in the pores which bears a part of the total stress, so partially unloading the solid matrix from normal stresses.
Terzaghi's principle applies well to porous materials whose solid constituents are incompressible - soil, for example, is composed of grains of incompressible silica so that the volume change in soil during consolidation is due solely to the rearrangement of these constituents with respect to one another. Generalizing Terzaghi's principle to include compressible solid constituents was accomplished by Maurice Anthony Biot in the 1940s, giving birth to the theory of poroelasticity and poromechanics.
Assumptions of Terzaghi's Principle
The soil is homogenous (uniform in composition throughout) and isotropic (show same physical property in each direction).
The soil is fully saturated (zero air voids due |
https://en.wikipedia.org/wiki/Osmotic%20dilator | Osmotic dilators are medical implements used to dilate the uterine cervix by swelling as they absorb fluid from surrounding tissue. They may be composed of natural or synthetic materials. A laminaria stick or tent is a thin rod made of the stems of dried Laminaria, a genus of kelp. Laminaria sticks can be generated from Laminaria japonica and Laminaria digitata. Synthetic osmotic dilators are commonly referred to by their brand names, such as Dilapan. Dilapan-S are composed of polyacrylonitrile, a plastic polymer. The hygroscopic nature of the polymer causes the dilator to absorb fluid and expand.
Use in obstetrics and gynecology
Osmotic dilators are most commonly used to slowly dilate and soften the cervix prior to surgical abortion, a process referred to as cervical preparation. Adequate cervical preparation is important prior to surgical abortions because it helps to prevent complications of dilation and evacuation (D&E), such as laceration of the cervix. Cervical preparation can be accomplished with osmotic dilators, with medications such as prostaglandins and/or mifepristone, or with a combination of these. However, there is no consensus as to which cervical preparation method is superior in terms of safety and efficacy.
At later gestational ages, osmotic dilators, including laminaria, may be used to assist in dilating the cervix. Most abortion providers use laminaria, Dilapan, or both for osmotic dilation prior to surgical abortion after 16–18 weeks gestation.
Osmo |
https://en.wikipedia.org/wiki/Richard%20Highton | Richard Highton (born December 24, 1927) is an American herpetologist, an expert on the biological classification of woodland salamanders.
Education and personal life
Highton was born in Chicago. His father encouraged his son to have an interest in herpetology. In 1950 he was awarded a bachelor's degree in biology, mathematics and sociology from New York University, with his studies interrupted by military service. He received his master's degree and Doctorate in Philosophy from the University of Florida. In 1950 he married Anne Adams and they had 4 children together.
Career
A field visit to the southern Appalachians mountains in 1948 with Carl Gans was the start of his work on salamanders.
In 1956 he joined the Zoology Department University of Maryland College Park, with emphasis on genetics and is currently Professor Emeritus in Biology. On his retirement in 1998, his collection of approximately 140,000 salamander specimens was donated to the Smithsonian Institution.
Since 1999 he has been a member of the Committee on Standard and English Scientific Names for North American Amphibians and Reptiles. He is the author or co-author of over 90 scientific publications.
Honours and awards
He was president of the American Society of Ichthyologists and Herpetologists in 1976 and President of the University of the Maryland Chapter of Sigma Xi from 1979 to 1980.
The intestinal parasite of salamanders Isospora hightoni was named in his honour.
References
University of Florida alu |
https://en.wikipedia.org/wiki/Steepletop | Steepletop, also known as the Edna St. Vincent Millay House, was the farmhouse home of Pulitzer Prize-winning poet Edna St. Vincent Millay and her husband Eugen Jan Boissevain, in Austerlitz, New York, United States. Her former home and gardens are maintained by the Edna St. Vincent Millay Society, a nonprofit organization that also holds the rights to the poet's intellectual property. Steepletop was declared a National Historic Landmark on November 11, 1971.
The Millay Colony for the Arts, founded by Norma Millay Ellis, sister of the poet and heir to her estate, is located on an adjacent plot of land. In 1973, it was established as a separate nonprofit organization from the Edna St. Vincent Millay society (aka, "Millay Society").
The name Steepletop comes from a pink, conical wildflower that grows there known as Steeplebush or Spiraea tomentosa. The Society opened the house for tours in 2010.
Property
Steepletop is a estate on a hilly, wooded area in the northeastern corner of the town near the Massachusetts state line. Although located within the range of the Taconic Mountains, the area is adjacent to the Berkshire Hills and is considered part of the cultural region of the Berkshires, known for its rich diversity in music, arts and recreation. The property is abutted on some areas by Beebe Hill and Harvey Mountain State Forest. It can be reached by taking partially paved East Hill Road to the main complex from the NY 22 state highway in the narrow valley to its west.
|
https://en.wikipedia.org/wiki/JA%20Solar%20Holdings | JA Solar Holdings is a solar development company founded in Yangpu district, Shanghai. They design, develop, manufacture and sell solar cell and solar module products and are based in the People’s Republic of China. The company is also engaged in the manufacturing and sales of monocrystalline and multicrystalline solar cells. It sells its products primarily through a team of sales and marketing personnel to solar module manufacturers, who assemble and integrate its solar cells into modules and systems that convert sunlight into electricity. It also manufactures a variety of standard and specialty solar modules. JA Solar Holdings also sells its products to customers in Germany, Italy, Sweden, Spain, South Korea, and the United States. The company was founded in 2005 and is based in Beijing, in the People’s Republic of China. In December 2009 investors began to notice the growing market share of JA Solar which was fueled by a large subsidy from the Chinese Government.
In February 2018 the company signed a deal with Manitu Solar for Manitu to distribute JA Solar's solar modules to markets in Eastern Europe.
See also
Solar power in China
References
External links
JA Solar Updates Agreement With BP Solar
Companies formerly listed on the Nasdaq
Solar energy companies of China
2007 initial public offerings
Manufacturing companies based in Beijing
Chinese brands |
https://en.wikipedia.org/wiki/Butyl%20iodide | Butyl iodide (1-iodobutane) is an organic compound which is an iodo derivative of butane. It is used as an alkylating agent.
Isomer
The compound isobutyl iodide AKA 1-iodo-2-methylpropane is isomeric to butyl iodide.
References
Alkylating agents
Iodoalkanes |
https://en.wikipedia.org/wiki/Little%20Cay | Little Cay is an island off the British Virgin Islands in the Caribbean. It lies approximately 1.5 km off the coast of Beef Island and serves an important role in its ecosystem, primarily composed of mangroves with diverse wildlife and corals. The island is currently uninhabited.
References
Islands of the British Virgin Islands |
https://en.wikipedia.org/wiki/Householder%27s%20method | In mathematics, and more specifically in numerical analysis, Householder's methods are a class of root-finding algorithms that are used for functions of one real variable with continuous derivatives up to some order . Each of these methods is characterized by the number , which is known as the order of the method. The algorithm is iterative and has a rate of convergence of .
These methods are named after the American mathematician Alston Scott Householder.
Method
Householder's method is a numerical algorithm for solving the equation . In this case, the function has to be a function of one real variable. The method consists of a sequence of iterations
beginning with an initial guess .
If is a times continuously differentiable function and is a zero of but not of its derivative, then, in a neighborhood of , the iterates satisfy:
, for some
This means that the iterates converge to the zero if the initial guess is sufficiently close, and that the convergence has order or better. Furthermore, when close enough to , it commonly is the case that for some . In particular,
if is even and then convergence to will be from the right;
if is even and then convergence to will be from the left;
if is odd and then convergence to will be from the side where it starts; and
if is odd and then convergence to will alternate sides.
Despite their order of convergence, these methods are not widely used because the gain in precision is not commensurate with the rise |
https://en.wikipedia.org/wiki/KBKL | KBKL (branded as "Kool 107.9") is a radio station serving Grand Junction, Colorado and vicinity with a classic hits format. This station broadcasts on FM frequency 107.9 MHz and is under ownership of Townsquare Media.
External links
Kool 107.9 - Official Site
Classic hits radio stations in the United States
BKL
Radio stations established in 1993
Townsquare Media radio stations |
https://en.wikipedia.org/wiki/Descartes%27%20theorem%20%28disambiguation%29 | Descartes' theorem may refer to:
Descartes' theorem concerning four mutually tangent circles
Descartes' theorem on total angular defect
Descartes' rule of signs |
https://en.wikipedia.org/wiki/Raghu%20Raj%20Bahadur | Raghu Raj Bahadur (30 April 1924 – 7 June 1997) was an Indian statistician considered by peers to be "one of the architects of the modern theory of mathematical statistics".
Biography
Bahadur was born in Delhi, India, and received his BA (1943) and MA (1945) in mathematics from St. Stephen’s College, University of Delhi . He received his doctorate from the University of North Carolina under Herbert Robbins in 1950 after which he joined University of Chicago. He worked as a research statistician at the Indian Statistical Institute in Calcutta from 1956 to 1961. He spent the remainder of his academic career in the University of Chicago. He is a cousin to Madhur Jaffrey.
Contributions
He published numerous papers and is best known for the concepts of "Bahadur efficiency" and the Bahadur–Ghosh–Kiefer representation (with J. K. Ghosh and Jack Kiefer).
He also framed the Anderson–Bahadur algorithm along with Theodore Wilbur Anderson which is used in statistics and engineering for solving binary classification problems when the underlying data have multivariate normal distributions with different covariance matrices.
Legacy
He held the John Simon Guggenheim Fellowship (1968–69) and was the 1974 Wald Lecturer of the IMS. He was the President of the Institute of Mathematical Statistics during 1974–75 and was elected a Fellow of the American Academy of Arts and Sciences in 1986.
References
External links
1924 births
1997 deaths
Indian statisticians
20th-century Indian mathem |
https://en.wikipedia.org/wiki/Ceramide%20glucosyltransferase | Ceramide glucosyltransferase (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucocerebroside.
It is classified under .
It is inhibited by miglustat and eliglustat, both drugs developed for the treatment of Gaucher disease.
See also
Glucocerebroside
References
External links
Transferases |
https://en.wikipedia.org/wiki/Alglucosidase%20alfa | Alglucosidase alfa, sold under the brand name Myozyme among others, is an enzyme replacement therapy (ERT) orphan drug for treatment of Pompe disease (Glycogen storage disease type II), a rare lysosomal storage disorder (LSD).
Chemically, the drug is an analog of the enzyme that is deficient in patients affected by Pompe disease, alpha-glucosidase. It is the first drug available to treat this disease.
It was approved for medical use in the United States in April 2006, as Myozyme and in May 2010, as Lumizyme.
Medical uses
Alglucosidase alfa is indicated for people with Pompe disease (GAA deficiency).
In 2014 the U.S. Food and Drug Administration announced the approval of alglucosidase alfa for treatment of people with infantile-onset Pompe disease, including people who are less than eight years of age. In addition, the Risk Evaluation and Mitigation Strategy (REMS) is being eliminated.
Side effects
Common observed adverse reactions to alglucosidase alfa treatment are pneumonia, respiratory complications, infections and fever. More serious reactions reported include heart and lung failure and allergic shock. Myozyme boxes carry warnings regarding the possibility of life-threatening allergic response.
Economics
Some American health plans have refused to subsidize Myozyme for adults because it lacks approval for treatment in adults, as well as its high cost (US$ 300,000 per year for life).
In 2015, Lumizyme was ranked the costliest drug per patient, with an average charge o |
https://en.wikipedia.org/wiki/U.S.%20Route%2070%20in%20North%20Carolina | U.S. Route 70 (US 70) is a part of the United States Numbered Highway System that runs from Globe, Arizona, to the Crystal Coast of the US state of North Carolina. In North Carolina, it is a major east–west highway that runs from the Tennessee border to the Atlantic Ocean. From the Tennessee state line near Paint Rock to Asheville it follows the historic Dixie Highway, running concurrently with US 25. The highway connects several major cities including Asheville, High Point, Greensboro, Durham, Raleigh, Goldsboro, and New Bern. From Beaufort on east, US 70 shares part of the Outer Banks Scenic Byway, a National Scenic Byway, before ending in the community of Atlantic, located along Core Sound.
US 70 is an original US Highway, signed on November 11, 1926, when the US Highway System was approved. Since then, the highway has been realigned in places. One of the larger extensions of US 70 came in 1931 when the highway was extended concurrently along North Carolina Highway 101 (NC 101) from Beaufort to Atlantic. While sections of US 70 have been converted to freeway standards, along most of the routing it is a four-lane highway. Several new projects beginning in the 2000s have placed US 70 on interstate grade freeways, such as the Clayton and Goldsboro bypasses. On May 24, 2016, AASHTO assigned the Future I-42 designation to the majority of US 70's routing east of Garner. Additionally, a short freeway segment in east Durham was officially designated as I-885 on June 30, 2022, a |
https://en.wikipedia.org/wiki/PlusTV | PlusTV was a finnish pay-broadcasting television network that was sign on 2006-2016 and is owned by Finnish telecommunications service DNA Oyj,
PlusTV turned into released in 2006 as a virtual terrestrial tv (DTT) service. It turned into the first commercial DTT service in Finland, and it quickly gained a following among visitors who have been looking for an alternative to conventional cable and satellite TV. PlusTV's primary selling factor was its wide range of channels, which includes numerous HD channels, which have been no longer available on different structures on the time.
One of the specific functions of PlusTV become its use of a hybrid broadcast broadband TV (HbbTV) platform. This platform allowed visitors to access extra content material and offerings, together with interactive applications and trap-up TV, via their broadband net connection. PlusTV become one of the first broadcasters in Europe to undertake this technology, and it helped to set up the carrier as a pacesetter within the virtual TV market.
Despite its early fulfillment, PlusTV faced some of challenges inside the years that accompanied. One of the largest demanding situations become the emergence of latest digital TV offerings, which include Netflix, Nickelodeon, Discovery Channel, MTV3, MTV Finland, MTV3 Juniori, Fakta, Eurosport and HBO Nordic, which provided on-call for streaming of TV indicates and movies. These offerings appealed to more youthful viewers who had been much less interested by co |
https://en.wikipedia.org/wiki/Amperex%20Electronic | Amperex Electronic Corporation was a manufacturer of vacuum tubes and semiconductors.
Brooklyn, New York
Originally located at 79 Washington Street in Brooklyn, New York, Amperex was a long-established manufacturer of transmitting tubes when they were acquired by the Dutch firm, Philips, (known more widely as Norelco in the US), around 1955. Philips continued to improve and enlarge the tube plant in New York, but also used the Amperex name to distribute their new line of Dutch-made miniature tubes, (12AX7, 12AU7, 12AT7) to feed the booming U.S. hi-fi market. Classic hi-fi brands such as Marantz, Fisher, and H. H. Scott, Inc., used these tubes. Amperex also produced the 6DJ8, 6922 and 7308 frame grid tubes. Developed by Amperex in 1958 when transistors were beginning to supplant tubes and originally developed for video and radar use, the 6DJ8 also excelled in audio amplifiers needing its high transconductance, and it still has a niche market among audiophiles.
Amperex tubes were original equipment parts in many models of Tektronix and Hewlett-Packard test equipment. Although Amperex stopped making vacuum tubes long ago, hoards of new old stock (especially the original "Bugle Boy" series) are traded for profit, and other manufacturers produced compatible tubes more recently.
Hicksville, New York
A new factory was constructed at 230 Duffy Avenue, Hicksville, New York, to manufacture electron tubes and semiconductors. Miniature receiving tubes, magnetrons, X-ray tubes, Gei |
https://en.wikipedia.org/wiki/Vince%20Hilaire | Vincent Mark Hilaire (born 10 October 1959) is a retired professional footballer who played in the Football League for Crystal Palace, Luton Town, Portsmouth, Leeds United, Stoke City and Exeter City. He was one of the first established black players in English football.
Career
Hilaire began his career with Crystal Palace as a 17-year-old in a 3–2 defeat at Lincoln City in March 1977 and rose to prominence with the side prophesied to be the "Team of the Eighties" after winning the Second Division championship title in 1978–79. He made 255 league appearances for Crystal Palace, scoring 29 goals, and was Supporters 'Player of The Year' in 1979 and 1980. He also played one summer season in the NASL with the San Jose Earthquakes in 1982.
He joined Luton Town in July 1984 but made only six appearances before being transferred to Portsmouth a few months later in November 1984, where he made 146 appearances, scoring 25 goals. He moved to Leeds United in the summer of 1988, playing 51 games and scoring seven goals, then moved on to Stoke City in November 1989 on loan, joining them on a permanent transfer in November 1990. He later joined Exeter City in 1991 where he made 33 appearances, scoring four goals, in the 1991–92 season. He joined Southern League side Waterlooville in the summer of 1992, as joint player-manager along with his ex-Palace teammate Billy Gilbert, but he left the club and retired from football before the end of the season, leaving Gilbert as sole player-manager. |
https://en.wikipedia.org/wiki/HMGA | HMGA is a family of high mobility group proteins characterized by an AT-hook. They code for a "small, nonhistone, chromatin-associated protein that has no intrinsic transcriptional activity but can modulate transcription by altering the chromatin architecture". Mammals have two orthologs: HMGA1 and HMGA2.
Genomic distribution
In mouse embryonic stem cells it has been demonstrated that both HMGA proteins binds uniformly to the DNA due to their AT-hook domains, with a slight preference for AT-rich regions/ Such regions tend to lack coding genes, an observation that argues against a direct role in transcriptional control and in agreement with previous studies, suggest that these proteins have a structural role in the chromatin, similar to histone.
Function
Normally, when cells are subjected to increased DNA damage (such as the formation of 6-O-methylguanine) this causes an increase in apoptosis (programmed cell death). However, cells with diminished activity for either proteins HMGA1 or HMGA2 (or both together) are more tolerant of such DNA damage than cells in which these proteins are not diminished. Thus a normal function of the HMGA1 and HMGA2 proteins appears to be to signal the presence of DNA damage leading to induction of apoptosis.
Association with human traits
Variations in HMGA2 to have a moderate association with adult height.
See also
HMGA1
HMGA2
References
External links
Transcription factors |
https://en.wikipedia.org/wiki/Jango%20%28TV%20series%29 | Jango is a British police comedy series produced in 1961 by Associated Rediffusion for ITV. It starred Robert Urquhart in the lead role of Jango Smith, with Moira Redmond as Dee Smith, his wife. The show also featured performances by Peter Sallis and Brian Wilde. The show's writer was Albert Henry Webb and its director was Cyril Coke.
Plot
Episode status
The show had eight episodes. All were believed lost, until the mid-1990s when a kinescope of one episode was discovered.
Reception
The Stage and Television Today criticised the show, writing, "The half-hour needs a dose of good comedy writing to make it work, because at present it is just feeble. A pity that delightful Moira Redmond cannot be featured in a programme of her own. She has an obvious feeling for a piquant comedy role, but cannot really make out with the present material."
References
External links
1961 British television series debuts
1961 British television series endings
1960s British sitcoms
1960s British police comedy television series
ITV sitcoms
English-language television shows
Black-and-white British television shows |
https://en.wikipedia.org/wiki/KEKB%20%28FM%29 | KEKB is a radio station serving Grand Junction, Colorado and its vicinity with a country music format. This station broadcasts on FM frequency 99.9 MHz and is under ownership of Townsquare Media, through licensee Townsquare License, LLC. The station began broadcasting May 24, 1984.
References
External links
99.9 KEKB - Official Site
Country radio stations in the United States
Radio stations established in 1984
EKB
Townsquare Media radio stations
1984 establishments in Colorado |
https://en.wikipedia.org/wiki/Anti-apolipoprotein%20antibodies | In autoimmune disease, anti-apolipoprotein H (AAHA) antibodies, also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These antibodies are involved in sclerosis and are strongly associated with thrombotic forms of lupus. As a result AAHA are strongly implicated in autoimmune deep vein thrombosis.
Also, it was proposed that AAHA is responsible for lupus anticoagulant. However, antiphospholipid antibodies bind phospholipids at sites similar to sites bound by anti-coagulants such as PAP1 sites and augment anti-coagulation activity.
This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically interacts with Apo-H. AHAA only inhibits the anti-coagulation activity in the presence of Apo-H and the AAHA component of ACLA correlates with a history of frequent thrombosis. This can be contrasted with lupus anticoagulant which inhibits agglutination in the presence of thrombin. A subset of AHAA appear to mimic the activity of lupus anticoagulant and increase Apo-H binding to phospholipids. These two activities can be differentiated by the binding to Apo-H domains, whereas binding to the 5th domain promotes that anti-coagulant activity binding to the more N-terminal domains promotes lupus anticoagulant-like activities.
AAHA interferes with factor Xa inhibition by Apo-H increasing factor Xa generation. However, like Apo-H the Lupus anticoagulant inhibits fac |
https://en.wikipedia.org/wiki/Vesiculo-vacuolar%20organelle | A vesiculo-vacuolar organelle (VVO) is an organelle that contributes to endothelial cell permeability. VVOs are found in the endothelium of normal blood vessels and vessels associated with tumors or allergic inflammation.
VVOs actively transport fluid and macromolecules from the cytoplasm of endothelial cells into the blood vessel lumen, contributing to the increase in vascular permeability that occurs during the process of inflammation. This kind of transport is mediated by VEGF, one of the chemical mediators of inflammation.
References
Organelles
Angiology |
https://en.wikipedia.org/wiki/SGM | SGM, or sgm, may refer to:
Science
Second Generation Multiplex DNA profiling system - also see SGM+
Scanning gate microscopy
Spherical Grating Monochromator beamline of Canadian Light Source
Semi-global matching algorithm in stereo imaging
16S rRNA (guanine1405-N7)-methyltransferase, an enzyme
Sexual and Gender Minorities
Organisations
SAIC-GM, joint venture between SAIC and General Motors
Scripture Gift Mission, London, UK
Servicio Geológico Mexicano, the Mexican Geological Survey
Sims Group Limited S&P/ASX 200 code
Sociedad Geológica Mexicana, the Mexican Geological Society
Sociedade Gestora de Fundos de Pensões Mundial, S.A., a subsidiary of Banco Internacional do Funchal
Sovereign Grace Ministries, later Sovereign Grace Churches
Swiss Meteorological Society (Schweizerische Gesellschaft für Meteorologie)
Places
Singkawang Grand Mall, Indonesia
1 SGM, a "census town" in India
South Glamorgan, preserved county in Wales, Chapman code
Transport
Schweizer SGM 1-19, a motorized glider
Schweizer SGM 2-37, a motorized glider
SGM, the National Rail code for St Germans railway station, Cornwall, UK
SGM, the IATA code for San Ignacio Airfield, Baja California Sur, Mexico
Stadsgewestelijk Materieel, a Dutch train
Other uses
Improved Soviet SG-43 Goryunov machine gun
Science Guard Members, in the Japanese Mirrorman (TV series)
Sea Gallantry Medal, UK
Sergeant Major, US military rank
SGM, another name for the GSM blend of Australian wine
sgm, the I |
https://en.wikipedia.org/wiki/RGS4 | Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling.
Function
Regulator of G protein signalling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain which conveys GAP activity. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulates signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm.
Clinical significance
A number of studies associate the RGS4 gene with schizophrenia, while some fail to detect an association.
RGS4 is also of interest as one of the three main RGS proteins (along with RGS9 and RGS17) involved in terminating signalling by the mu opioid receptor, and may be important in the development of tolerance to opioid drugs.
Inhibitors
cyclic peptides
CCG-4986
Interactions
RGS4 has been shown to interact with:
COPB2,
ERBB3, and
GNAQ.
References
Further reading
Proteins |
https://en.wikipedia.org/wiki/Sequence%20hypothesis | The sequence hypothesis was first formally proposed in the review "On Protein Synthesis" by Francis Crick in 1958. It states that the sequence of bases in the genetic material (DNA or RNA) determines the sequence of amino acids for which that segment of nucleic acid codes, and this amino acid sequence determines the three-dimensional structure into which the protein folds. The three-dimensional structure of a protein is required for a protein to be functional. This hypothesis then lays the essential link between information stored and inherited in nucleic acids to the chemical processes which enable life to exist.
Or, as Crick put it in 1958:
This description is further amplified in the article and, in discussing how a protein folds up into its three-dimensional structure, Crick suggested that "the folding is simply a function of the order of the amino acids" in the protein.
References
See also
Central dogma of molecular biology
Nucleic acids
Biology theories |
https://en.wikipedia.org/wiki/Anton%20Lichkov | Anton Lichkov (: born 5 August 1980 in Petrich) is a Bulgarian former footballer, who played as a defender.
External links
2007-08 Statistics, 2006-07 Statistics & 2005-06 Statistics at PFL.bg
1980 births
Living people
Bulgarian men's footballers
First Professional Football League (Bulgaria) players
PFC Slavia Sofia players
PFC Beroe Stara Zagora players
OFC Belasitsa Petrich players
FC Montana players
People from Petrich
Men's association football defenders
Footballers from Blagoevgrad Province |
https://en.wikipedia.org/wiki/Zhelyo%20Zhelev | Zhelyo Zhelev (born 24 February 1987 in Stara Zagora) is a Bulgarian footballer currently playing for Vereya Stara Zagora as a midfielder.
External links
2007-08 Statistics
Bulgarian men's footballers
1987 births
Living people
First Professional Football League (Bulgaria) players
PFC Beroe Stara Zagora players
Men's association football midfielders
Footballers from Stara Zagora |
https://en.wikipedia.org/wiki/Cell%20synchronization | Cell synchronization is a process by which cells in a culture at different stages of the cell cycle are brought to the same phase. Cell synchrony is a vital process in the study of cells progressing through the cell cycle as it allows population-wide data to be collected rather than relying solely on single-cell experiments. The types of synchronization are broadly categorized into two groups; physical fractionization and chemical blockade.
Physical Separation
Physical fractionation is a process by which continuously dividing cells are separated into phase-enriched populations based on characteristics such as the following:
Cell density
Cell size
The presence of cell surface epitopes marked by antibodies
Light scatter
Fluorescent emission by labeled cells.
Given that cells take on varying morphologies and surface markers throughout the cell cycle, these traits can be used to separate by phase. There are two commonly used methods.
Centrifugal Elutriation
(Previously called: counter streaming centrifugation) Centrifugal elutriation can be used to separate cells in different phases of the cell cycle based on their size and sedimentation velocity (related to sedimentation coefficient). Because of the consistent growth patterns throughout the cell cycle, centrifugal elutriation can separate cells into G1, S, G2, and M phases by increasing size (and increasing sedimentation coefficients) with diminished resolution between G2 and M phases due to cellular heterogeneity and lack |
https://en.wikipedia.org/wiki/Humbertus |
Humbertus was a medieval Bishop of Elmham.
Humbertus was consecrated before 824. Medieval hagiographies of Edmund the Martyr say that Humbertus crowned the young Edmund at Burna on Christmas Day 856.
He was martyred by the Danes. His date of death is uncertain; he may have died possibly in November 869.
After Humbertus, there was an interruption with the episcopal succession through the Danish Viking invasions in the late 9th and early 10th centuries. By the mid-10th century, the sees Elmham and Dunwich had been united under Bishop Eadwulf.
Notes
References
External links
Bishops of Elmham
English Roman Catholic saints
9th-century Christian saints
870 deaths
East Anglian saints
Year of birth unknown
la:Humbertus
nl:Humbertus |
https://en.wikipedia.org/wiki/CDF%20Aviation%20Management%20Program | The CAL FIRE Aviation Management Program is a branch of the California Department of Forestry and Fire Protection (known also as CAL FIRE). Due to the frequency and severity of wildfires in California, the state has elected to establish its own aerial firefighting force rather than rely solely on national resources. The Aviation Management Program is based at McClellan Airfield near Sacramento, California.
Overview
In support of its ground forces, the California Department of Forestry and Fire Protection (CAL FIRE) emergency response air program includes 23 Grumman S-2T 1,200 gallon airtankers, 12 UH-1H Super Huey helicopters, and 16 OV-10A airtactical aircraft. It is in the process of adding 7 C-130H 4,000 gallon airtankers. These aircraft are stationed at 14 airtanker and 11 (10 CAL FIRE, 1 joint CAL FIRE/San Diego County Sheriff) helitack bases located statewide, and can reach most fires within 20 minutes. During high fire activity, CAL FIRE may move aircraft to better provide statewide air support.
The airtactical planes fly overhead at a fire, directing the airtankers and helicopters to critical areas of the fire for retardant and water drops. The retardant used to slow or retard the spread of a fire is a slurry mix consisting of a chemical salt compound, water, clay or a gum-thickening agent, and a coloring agent. While both air tankers and helicopters are equipped to carry fire retardant or water, the helicopters can also transport firefighters, equipment and injured |
https://en.wikipedia.org/wiki/Percoll | Percoll is a tool for efficient density separation in Cell biology that was first formulated by Pertoft and colleagues. It is used for the isolation of cells, organelles, and/or viruses by density centrifugation. Percoll consists of colloidal silica particles of 15–30 nm diameter (23% w/w in water) which have been coated with polyvinylpyrrolidone (PVP).
Percoll is well suited for density gradient experiments because it possesses a low viscosity compared to alternatives, a low osmolarity, and no toxicity towards cells and their constituents.
Percoll is a registered trademark of GE Healthcare.
Characteristics
Percoll does not notably diffuse over time, resulting in the formation of very stable gradients. Therefore, both discontinuous and continuous Percoll density gradients can be prepared weeks in advance, allowing great reproducibility & ease of use.
Past use in artificial reproduction
Percoll was previously used in assisted reproductive technology (ART) to select sperm from semen by density gradient centrifugation, for use in techniques such as in vitro fertilization or intrauterine insemination. However, in 1996, Pharmacia sent out a letter to laboratories stating that Percoll should be used for research purposes only, not clinical. Pharmacia had not marketed it as a sperm preparation product; it had been repackaged and sold as such by third-party manufacturers. The FDA Warning Letter was due to concerns that PVP might cause damage to sperm (an unknown issue), and also |
https://en.wikipedia.org/wiki/Trentepohliales | Trentepohliales is an order of Ulvophyceaen green algae. The order is characterized by traits like net-like chloroplasts without pyrenoids, cell walls with plasmodesmata and cytokinesis by production of a phragmoplast.
References
Chlorophyta orders
Ulvophyceae |
https://en.wikipedia.org/wiki/Jouni%20Loponen | Jouni Loponen (born 1 July 1971) is a Finnish ice hockey defender. He played for the Spokane Chiefs in 1988–89, he is a 4-times Finnish champion and in 2004, he won Elitserien.
Career statistics
References
External links
Eurohockey.net profile
Finnish ice hockey defencemen
Spokane Chiefs players
HC TPS players
Living people
1971 births |
https://en.wikipedia.org/wiki/Cartilage%20oligomeric%20matrix%20protein | Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.
Function
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
COMP is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.
References
Further reading
External links
GeneReviews/NCBI/NIH/UW entry on Pseudoachondroplasia
GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant
Extracellular matrix proteins
Thrombospondins |
https://en.wikipedia.org/wiki/Ziproxy | Ziproxy is a forwarding, non-caching, compressing, HTTP proxy server targeted for traffic optimization.
The ziproxy software is regarded as lightweight in terms of memory and processing power consumption.
This software works by recompressing pictures (such as JPEG, GIF, PNG, JPEG 2000), gzipping text and HTML/JS/CSS data optimization. Additionally it offers latency reduction by preemptive name resolution.
Further functionalities of compression are supplied by means of optimization of code, named HTMLopt, CSSopt and JSopt (HTML/CSS/JS) which are analogous with Minification (programming).
Currently there are ports being maintained by third parties for Debian, Gentoo Linux, FreeBSD, and OpenBSD.
See also
Bandwidth management for measuring and controlling the communications (traffic, packets) on a network link
Comparison of web servers
Comparison of lightweight web servers
Proxy server which discusses client-side proxies
Reverse proxy which discusses origin-side proxies
Web accelerator which discusses host-based HTTP acceleration
External links
Official project homepage
Debian entry
FreeBSD ports entry
Gentoo-Portage entry
Ziproxy for iPhone - iPhone as a Ziproxy client
Ziproxy - Proxy de compactação e redução de imagens
Web accelerators
Proxy servers
Unix network-related software |
https://en.wikipedia.org/wiki/Yugant | Yugant () is a 1995 Bengali drama movie directed by Aparna Sen. The movie featured Anjan Dutt and Roopa Ganguly.
Plot
Deepak and Anasuya are an estranged couple, now leading separate lives in Cuttack and Bombay. They meet again after 18 months of separation, at a small fishing village where they had once honeymooned. Though driven apart by their careers, Deepak and Anasuya realize that their feelings for each other have not changed, and slowly they struggle for reconciliation.
Though this may be the story's outline (a fictional line for screenplay), the film really speaks about the Gulf war (war for Oil) and its impact on our environment, living creatures and humans.
Cast
Awards
1995 : National Film Awards
Best Feature Film in Bengali
Best Choreography: Ileana Citaristi
References
External links
1995 films
Bengali-language Indian films
Films featuring a Best Choreography National Film Award-winning choreography
Best Bengali Feature Film National Film Award winners
Films directed by Aparna Sen
1990s Bengali-language films
National Film Development Corporation of India films |
https://en.wikipedia.org/wiki/Jonathan%20Hivert | Jonathan Hivert (born 23 March 1985) is a former French professional road bicycle racer, who last rode for UCI ProTeam .
Career
In 2013, Chambray-lès-Tours Hivert won the general classification of the 2.1 event Étoile de Bessèges. He was 3 seconds in arrears of Jérôme Cousin of before the final time trial, and he finally got the first position after besting Cousin by 7 seconds on the stage. Hivert joined for the 2014 season, after his previous team – – folded at the end of the 2013 season.
In October 2020, he was named in the startlist for the 2020 Vuelta a España. In the same month, Hivert signed a two-year contract with the team, later renamed as .
Major results
2003
2nd Road race, National Junior Road Championships
2005
2nd Paris–Mantes-en-Yvelines
6th Liège–Bastogne–Liège U23
2007
5th Overall Tour de Luxembourg
2008
2nd Overall Circuit de Lorraine
1st Stage 1
6th Grand Prix d'Ouverture La Marseillaise
6th Tour du Doubs
10th Overall Étoile de Bessèges
10th Tour de Vendée
2009
5th Hel van het Mergelland
6th Overall Étoile de Bessèges
6th Grand Prix de Wallonie
8th Overall Paris–Nice
8th Grand Prix d'Ouverture La Marseillaise
2010
1st Grand Prix d'Ouverture La Marseillaise
2nd Tour du Doubs
3rd Tour de Vendée
4th Grand Prix d'Isbergues
9th Overall Paris–Corrèze
2011
1st Klasika Primavera
1st Paris–Troyes
1st Stage 2 Vuelta a Andalucía
2nd Overall Tour du Gévaudan
4th Boucles de l'Aulne
2012
1st Stage 2 Tour de Romandie
2nd Tour de Vendée
4 |
https://en.wikipedia.org/wiki/Police%20Forensic%20Science%20Laboratory%20Dundee | The Police Forensic Science Laboratory Dundee (PFSLD) was established in April 1989. There are four main departments: Biology, Chemistry, the national DNA Database and Quality/Administration.
PFSLD is funded by and serves Central Scotland Police, Fife Constabulary and Tayside Police and along with the 3 other police laboratories in Scotland, is independent from the Forensic Science Service of England and Wales. The PFSLD houses the DNA database for the whole of Scotland, and exports copies to the UK National DNA Database.
Further reading
See also
DNA
Forensic science
Law enforcement in Scotland
External links
Official website
1989 establishments in Scotland
Law enforcement agencies of Scotland
Organisations based in Dundee
Science and technology in Dundee
Databases in Scotland
Government databases in the United Kingdom
Government agencies established in 1989
Forensics organizations
Science and technology in Scotland |
https://en.wikipedia.org/wiki/Vbcc | vbcc is a portable and retargetable ANSI C compiler. It supports C89 (ISO/IEC 9899:1989) as well as parts of C99 (ISO/IEC 9899:1999).
It is divided into two parts. One is target-independent and the other is target-dependent. vbcc provides complete abstraction of host-arithmetic and target-arithmetic. It fully supports cross-compiling for 8-bit, 16-bit, 32-bit and 64-bit architectures.
Embedded systems are supported by features such as different pointer sizes, ROM-able code, inline assembly, bit-types, interrupt handlers, section attributes, and stack usage calculation (depending on the backend).
vbcc supports the following backends, with different degrees of maturity: 68K, ColdFire, PowerPC, 6502, VideoCore, 80x86 (386 and above), Alpha, C16x/ST10, 6809/6309/68HC12, and Z-machine.
The compiler itself can run on all common operating systems, including Windows, Mac OS X, and Unix/Linux.
Optimizations
The compiler provides a large set of high-level optimizations as well as target-specific optimizations to produce faster or smaller code. It is also able to optimize across functions and modules. Target-independent optimizations supported by vbcc include:
cross-module function inlining
partial inlining of recursive functions
interprocedural dataflow analysis
interprocedural register allocation
register allocation for global variables
global common subexpression elimination
global constant propagation
global copy propagation
dead code elimination
alias analysis
loop |
https://en.wikipedia.org/wiki/Polilight | The Polilight is a portable, high-intensity, filtered light source used by forensic scientists and others to detect fingerprints, bodily fluids and other evidence from crime scenes and other places.
Similar products to the Polilight Hola include the Foster + Freeman Crime-lite, Ultralite ALS and the Optimax Multilite, all of which use light-emitting diodes to produce high-intensity light of varying wavelengths.
History
The device was invented by Pierre Margot, Ron Warrener, Hilton Kobus, Milutin Stoilovic and Chris Lennard. It was developed from a research project to find an alternative to the laser method of fingerprint detection used in the 1970s. In the 1980s, the project began at the Australian National University. It was funded by the Australian Federal Police. The university's commercial company, Anutech Pty Ltd, sold the concept to Rofin Australia Pty Ltd, who developed it into the Polilight.
Several Polilight models have been released, including the Polilight 6/150W, Polilight 10/300W and the Polilight500, sometimes abbreviated to PL6, PL10 and PL500. The PL500 ('500' refers to the power in watts of the xenon arc lamp) has eleven monochromatic bands, a ‘blank’ position that provides high intensity white light in the range from 380 to 650 nm and an optional infra-red output suitable for document examination.
The Polilight was named by the Powerhouse Museum as one of the top 100 Australian innovations of the 20th century. Its worldwide use was acknowledged by the |
https://en.wikipedia.org/wiki/European%20Collection%20of%20Authenticated%20Cell%20Cultures | The European Collection of Authenticated Cell Cultures houses and supplies cell lines.
It is part of the Culture Collections of Public Health England. The collection is held in Porton Down.
ECACC, which was established in 1985, consists of a team with specialist knowledge which supply authenticated cell lines, induced Pluripotent stem cells (iPSCs) and nucleic acids to provide stock for the research community. ECACC is one of the first collections of authenticated cell cultures worldwide and now holds cell lines from 45 species including 50 tissue types, 300 HLA types, over 800 genetic disorders and roughly 450 monoclonal antibodies.
ECACC products are trademarked with Public Health England and the trademark cannot be used without a licence agreement which can be requested through contact with PHE Culture Collections. All ECACC products can be found at the culture collections website alongside a range of services such as Mycoplasma testing and training courses for cell culture.
References
External links
Culture Collections
Official home page
Biological research institutes in the United Kingdom
Culture collections
Genetics in the United Kingdom
Microbiology organizations
Public Health England
Science and technology in Wiltshire |
https://en.wikipedia.org/wiki/2007%20bomb%20plot%20in%20Germany | The 2007 bomb plot in Germany, planned by the al-Qaeda controlled Islamic Jihad Union (IJU), affiliated Sauerland terror cell (), was discovered following an extensive nine-month investigation. That involved more than 600 agents in five German states. The number of agents involved in a counterterrorism operation led by the federal police had never been the case before. At the same time, Danish police in Copenhagen were busy with explosives. A Pakistani and an Afghan man have been charged with preparing to carry out their attacks under al-Qaeda plans. Authorities said they were unaware of any direct links between the terrorists arrested in the two European countries. Three men were arrested on 4 September 2007 while leaving a rented cottage in the Oberschledorn district of Medebach, Germany where they had stored 700 kg (1,500 lb) of a hydrogen peroxide-based mixture and 26 military-grade detonators, and were attempting to build car bombs. A supporter was arrested in Turkey. All four had attended an IJU-training camp in the border region between Afghanistan and Pakistan in 2006. They were convicted in 2010 and given prison sentences of varying lengths; all have since been released.
Perpetrators
Two of the perpetrators were German converts to Islam from Christianity, and two were German-Turks. In 2006, all four attended a paramilitary training camp run by the Islamic Jihad Union in Waziristan.
The perpetrators were primarily motivated by strong anti-Americanism fuelled by int |
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