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https://en.wikipedia.org/wiki/Zodiac%20Man
Sometimes depicted in writings and drawings from ancient classical, medieval, and modern times, the Zodiac Man (Homo Signorum or "Man of Signs") represents a roughly consistent correlation of zodiacal names with body parts. The Zodiac Man appeared most frequently in calendars, devotional Books of Hours, and treatises on philosophy, astrology, and medicine in the medieval era. Before the emergence of scientific empiricism in the 17th century, medieval physicians looked to the skies for guidance. Having observed that the overhead moon brought high tides, they theorized the dangers of letting blood from a body part whose zodiacal sign was occupied by the moon since a tide of blood might gush out uncontrollably. Table of correspondences The association of body parts with zodiac signs remained relatively consistent during antiquity and into the medieval period. The "primary" associations are both the oldest and the most common. Ancient origins The concept of the Zodiac Man dates to the Hellenistic era in which the earliest exposition appears in Manilius's Astronomica (II. 453–465; IV. 701–710). However, a cuneiform tablet of unknown date gives a nearly identical list of bodily divisions that possibly but not certainly could have been created before Manilius. A Greek text (περὶ μελῶν ζωδίων - On the limbs of the zodiacal sign) describing the subdivision of zodiac signs into dodecatemoria (signs within signs) suggests that Zodiac Man (or Zodiac Animal, modified slightly to suit each sign) could also be associated with the idea of this "micro-zodiac". Overall, the idea of Zodiac Man goes back thousands of years to Babylonia where the body was considered to work in tune with the heavenly bodies. The general system of zodiac signs relating to healing is thought to predate Manilius by several centuries and has been attributed to philosophers such as Pythagoras, Democritus, Aristotle, and Hermes. Astrological medicine The Zodiac Man was used in medieval medicine to dete
https://en.wikipedia.org/wiki/Proctodeum
A proctodeum is the back ectodermal part of an alimentary canal. It is created during embryogenesis by a folding of the outer body wall. It will form the lower part of the anal canal, below the pectinate line, which will be lined by stratified squamous non-keratinized (zona hemorrhagica) and stratified squamous keratinized (zona cutanea) epithelium. The junction between them is Hilton's white line. External links Embryology of digestive system
https://en.wikipedia.org/wiki/Affective%20forecasting
Affective forecasting (also known as hedonic forecasting, or the hedonic forecasting mechanism) is the prediction of one's affect (emotional state) in the future. As a process that influences preferences, decisions, and behavior, affective forecasting is studied by both psychologists and economists, with broad applications. History In The Theory of Moral Sentiments (1759), Adam Smith observed the personal challenges, and social benefits, of hedonic forecasting errors: [Consider t]he poor man's son, whom heaven in its anger has visited with ambition, when he begins to look around him, admires the condition of the rich …. and, in order to arrive at it, he devotes himself for ever to the pursuit of wealth and greatness…. Through the whole of his life he pursues the idea of a certain artificial and elegant repose which he may never arrive at, for which he sacrifices a real tranquillity that is at all times in his power, and which, if in the extremity of old age he should at last attain…, he will find to be in no respect preferable to that humble security and contentment which he had abandoned for it. It is then, in the last dregs of life, his body wasted with toil and diseases, his mind galled and ruffled by the memory of a thousand injuries and disappointments..., that he begins at last to find that wealth and greatness are mere trinkets of frivolous utility…. [Yet] it is well that nature imposes upon us in this manner. It is this deception which rouses and keeps in continual motion the industry of mankind. In the early 1990s, Kahneman and Snell began research on hedonic forecasts, examining its impact on decision making. The term "affective forecasting" was later coined by psychologists Timothy Wilson and Daniel Gilbert. Early research tended to focus solely on measuring emotional forecasts, while subsequent studies began to examine the accuracy of forecasts, revealing that people are surprisingly poor judges of their future emotional states. For example, in pred
https://en.wikipedia.org/wiki/Ligule
A ligule (from "strap", variant of lingula, from lingua "tongue") is a thin outgrowth at the junction of leaf and leafstalk of many grasses (Poaceae) and sedges. A ligule is also a strap-shaped extension of the corolla, such as that of a ray floret in plants in the daisy family Asteraceae. Poaceae and Cyperaceae The ligule is part of the leaf that is found at the junction of the blade and sheath of the leaf. It may take several forms, but it is commonly some form of translucent membrane or a fringe of hairs. The membranous ligule can be very short 1–2 mm (Kentucky bluegrass, Poa pratensis) to very long 10–20 mm (Johnson grass, Sorghum halepense), it can also be smooth on the edge or very ragged. Some grasses do not have a ligule, for example barnyardgrass (Echinochloa crus-galli). A ligule can also be defined as a membrane-like tissue or row of delicate hairs typically found in grasses at the junction of the leaf sheath and blade. The ligule appears to be a continuation of the leaf sheath and encircles or clasps the stem as does the leaf sheath. The three basic types of ligules are: membranous, a fringe of hairs (ciliate), and absent or lacking. Most grasses have ligules, and the shape, length, and appearance of the ligule margin provide consistent characters for separating genera and some species of grasses. In grass-like plants such as sedges (Cyperaceae) and rushes (Juncaceae), ligules are usually absent or poorly developed. Asteraceae In members of Asteraceae, a ligule is the elongated tongue of the corolla of a ray flower or ligulate flower. Clubmosses The microphylls of Lycopodiophyta of the families Selaginellaceae (spikemosses or lesser clubmosses) and Isoetaceae (quillworts) have minute, scale-like flaps of tissue called ligules at the base of the upper surface of each leaf blade. This feature distinguishes them from clubmosses of the family Lycopodiaceae.
https://en.wikipedia.org/wiki/Passive%20dynamics
Passive dynamics refers to the dynamical behavior of actuators, robots, or organisms when not drawing energy from a supply (e.g., batteries, fuel, ATP). Depending on the application, considering or altering the passive dynamics of a powered system can have drastic effects on performance, particularly energy economy, stability, and task bandwidth. Devices using no power source are considered "passive", and their behavior is fully described by their passive dynamics. In some fields of robotics (legged robotics in particular), design and more relaxed control of passive dynamics has become a complementary (or even alternative) approach to joint-positioning control methods developed through the 20th century. Additionally, the passive dynamics of animals have been of interest to biomechanists and integrative biologists, as these dynamics often underlie biological motions and couple with neuromechanical control. Particularly relevant fields for investigating and engineering passive dynamics include legged locomotion and manipulation. History The term and its principles were developed by Tad McGeer in the late 1980s. While at Simon Fraser University in Burnaby, British Columbia, McGeer showed that a human-like frame can walk itself down a slope without requiring muscles or motors. Unlike traditional robots, which expend energy by using motors to control every motion, McGeer's early passive-dynamic machines relied only on gravity and the natural swinging of their limbs to move forward down a slope. Models The original model for passive dynamics is based on human and animal leg motions. Completely actuated systems, such as the legs of the Honda Asimo robot, are not very efficient because each joint has a motor and control assembly. Human-like gaits are far more efficient because movement is sustained by the natural swing of the legs instead of motors placed at each joint. Tad McGeer's 1990 paper "Passive Walking with Knees" provides an excellent overview on the adv
https://en.wikipedia.org/wiki/Nuclear%20power%20phase-out
A nuclear power phase-out is the discontinuation of usage of nuclear power for energy production. Often initiated because of concerns about nuclear power, phase-outs usually include shutting down nuclear power plants and looking towards fossil fuels and renewable energy. Three nuclear accidents have influenced the discontinuation of nuclear power: the 1979 Three Mile Island partial nuclear meltdown in the United States, the 1986 Chernobyl disaster in the USSR (now Ukraine), and the 2011 Fukushima nuclear disaster in Japan. Following Fukushima, Germany has permanently shut down eight of its 17 reactors and pledged to close the rest by the end of 2022. In late 2021 all but three of the remaining German nuclear power plants were shut down. However, there are no plans to shut down the research reactor in Garching, Forschungsreaktor München II. Italy voted overwhelmingly to keep their country non-nuclear. Switzerland and Spain have banned the construction of new reactors. Japan's prime minister called for a dramatic reduction in Japan's reliance on nuclear power. Taiwan's president did the same. Shinzō Abe, the prime minister of Japan from 2012 to 2020, announced a plan to re-start some of the 54 Japanese nuclear power plants (NPPs) and to continue some NPP sites under construction. The impacts of the nuclear shut-downs on the power generation mix, post-Fukushima, have significantly set back emissions reductions goals in these countries. A recent study of the impacts of the German and Japan phaseouts concludes that by continuing to operate their nuclear plants "these two countries could have prevented 28,000 air pollution-induced deaths and 2400 MtCO2 emissions between 2011 and 2017.""By sharply reducing nuclear instead of coal and gas after Fukushima both countries lost the chance to prevent very large amounts of air pollution-induced deaths and emissions". As of 2021 Japan planned on restarting 30 reactors by 2030 as well as investing in future small modular reactor
https://en.wikipedia.org/wiki/Ricci%20decomposition
In the mathematical fields of Riemannian and pseudo-Riemannian geometry, the Ricci decomposition is a way of breaking up the Riemann curvature tensor of a Riemannian or pseudo-Riemannian manifold into pieces with special algebraic properties. This decomposition is of fundamental importance in Riemannian and pseudo-Riemannian geometry. Definition of the decomposition Let (M,g) be a Riemannian or pseudo-Riemannian n-manifold. Consider its Riemann curvature, as a (0,4)-tensor field. This article will follow the sign convention written multilinearly, this is the convention With this convention, the Ricci tensor is a (0,2)-tensor field defined by Rjk=gilRijkl and the scalar curvature is defined by R=gjkRjk. (Note that this is the less common sign convention for the Ricci tensor; it is more standard to define it by contracting either the first and third or the second and fourth indices, which yields a Ricci tensor with the opposite sign. Under that more common convention, the signs of the Ricci tensor and scalar must be changed in the equations below.) Define the traceless Ricci tensor and then define three (0,4)-tensor fields S, E, and W by The "Ricci decomposition" is the statement As stated, this is vacuous since it is just a reorganization of the definition of W. The importance of the decomposition is in the properties of the three new tensors S, E, and W. Terminological note. The tensor W is called the Weyl tensor. The notation W is standard in mathematics literature, while C is more common in physics literature. The notation R is standard in both, while there is no standardized notation for S, Z, and E. Basic properties Properties of the pieces Each of the tensors S, E, and W has the same algebraic symmetries as the Riemann tensor. That is: together with The Weyl tensor has the additional symmetry that it is completely traceless: Hermann Weyl showed that W has the remarkable property of measuring the deviation of a Riemannian or pseudo-Riemannian manifo
https://en.wikipedia.org/wiki/False%20nearest%20neighbor%20algorithm
Within abstract algebra, the false nearest neighbor algorithm is an algorithm for estimating the embedding dimension. The concept was proposed by Kennel et al. (1992). The main idea is to examine how the number of neighbors of a point along a signal trajectory change with increasing embedding dimension. In too low an embedding dimension, many of the neighbors will be false, but in an appropriate embedding dimension or higher, the neighbors are real. With increasing dimension, the false neighbors will no longer be neighbors. Therefore, by examining how the number of neighbors change as a function of dimension, an appropriate embedding can be determined. See also Commutative ring Local ring Nearest neighbor Time series
https://en.wikipedia.org/wiki/Potentiostat
A potentiostat is the electronic hardware required to control a three electrode cell and run most electroanalytical experiments. A Bipotentiostat and polypotentiostat are potentiostats capable of controlling two working electrodes and more than two working electrodes, respectively. The system functions by maintaining the potential of the working electrode at a constant level with respect to the reference electrode by adjusting the current at an auxiliary electrode. The heart of the different potentiostatic electronic circuits is an operational amplifier (op amp). It consists of an electric circuit which is usually described in terms of simple op amps. Primary use This equipment is fundamental to modern electrochemical studies using three electrode systems for investigations of reaction mechanisms related to redox chemistry and other chemical phenomena. The dimensions of the resulting data depend on the experiment. In voltammetry, electric current in amps is plotted against electric potential in voltage. In a bulk electrolysis total coulombs passed (total electric charge) is plotted against time in seconds even though the experiment measures electric current (amperes) over time. This is done to show that the experiment is approaching an expected number of coulombs. Most early potentiostats could function independently, providing data output through a physical data trace. Modern potentiostats are designed to interface with a personal computer and operate through a dedicated software package. The automated software allows the user rapidly to shift between experiments and experimental conditions. The computer allows data to be stored and analyzed more effectively, rapidly, and accurately than the earlier standalone devices. Basic relationships A potentiostat is a control and measuring device. It comprises an electric circuit which controls the potential across the cell by sensing changes in its resistance, varying accordingly the current supplied
https://en.wikipedia.org/wiki/Ponceau%204R
Ponceau 4R (known by more than 100 synonyms, including as C.I. 16255, cochineal red A, C.I. acid red 18, brilliant scarlet 3R, brilliant scarlet 4R, new coccine,) is a synthetic colourant that may be used as a food colouring. It is denoted by E Number E124. Its chemical name is 1-(4-sulfo-1-napthylazo)-2-napthol-6,8-disulfonic acid, trisodium salt. Ponceau (17th century French for "poppy-coloured") is the generic name for a family of azo dyes. Ponceau 4R is a strawberry red azo dye which can be used in a variety of food products, and is usually synthesized from aromatic hydrocarbons; it is stable to light, heat, and acid but fades in the presence of ascorbic acid. It is used in Europe, Asia, and Australia, but has not been approved for human consumption by the United States Food and Drug Administration. Health effects There is no evidence of carcinogenicity, genotoxicity, neurotoxicity, or reproductive and developmental toxicity at the permitted dietary exposures; the European acceptable daily intake (ADI) is 0.7 mg/kg and the WHO/FAO ADI is 4 mg/kg. The production process may result in unsulfonated aromatic amines present in concentrations of up to 100 mg/kg which may be linked to cancer. The lake pigment form of the colour additive can also increase the intake of aluminium beyond the tolerable weekly intake (TWI) of 1 mg/kg/week. Therefore, the limit for aluminium may be adjusted to accommodate for this. Possible cause of hyperactivity Since the 1970s and the well-publicized advocacy of Benjamin Feingold, there has been public concern that food colourings may cause ADHD-like behavior in children. These concerns have led the FDA and other food safety authorities to regularly review the scientific literature, and led the UK FSA to commission a study by researchers at Southampton University of the effect of a mixture of six food dyes (Tartrazine, Allura Red AC, Ponceau 4R, Quinoline Yellow WS, Sunset Yellow and Carmoisine, dubbed the "Southampton 6") and sod
https://en.wikipedia.org/wiki/Mass%20balance
In physics, a mass balance, also called a material balance, is an application of conservation of mass to the analysis of physical systems. By accounting for material entering and leaving a system, mass flows can be identified which might have been unknown, or difficult to measure without this technique. The exact conservation law used in the analysis of the system depends on the context of the problem, but all revolve around mass conservation, i.e., that matter cannot disappear or be created spontaneously. Therefore, mass balances are used widely in engineering and environmental analyses. For example, mass balance theory is used to design chemical reactors, to analyse alternative processes to produce chemicals, as well as to model pollution dispersion and other processes of physical systems. Closely related and complementary analysis techniques include the population balance, energy balance and the somewhat more complex entropy balance. These techniques are required for thorough design and analysis of systems such as the refrigeration cycle. In environmental monitoring, the term budget calculations is used to describe mass balance equations where they are used to evaluate the monitoring data (comparing input and output, etc.). In biology, the dynamic energy budget theory for metabolic organisation makes explicit use of mass and energy balance. Introduction The general form quoted for a mass balance is The mass that enters a system must, by conservation of mass, either leave the system or accumulate within the system. Mathematically the mass balance for a system without a chemical reaction is as follows: Strictly speaking the above equation holds also for systems with chemical reactions if the terms in the balance equation are taken to refer to total mass, i.e. the sum of all the chemical species of the system. In the absence of a chemical reaction the amount of any chemical species flowing in and out will be the same; this gives rise to an equation for each sp
https://en.wikipedia.org/wiki/Immunoelectrophoresis
Immunoelectrophoresis is a general name for a number of biochemical methods for separation and characterization of proteins based on electrophoresis and reaction with antibodies. All variants of immunoelectrophoresis require immunoglobulins, also known as antibodies, reacting with the proteins to be separated or characterized. The methods were developed and used extensively during the second half of the 20th century. In somewhat chronological order: Immunoelectrophoretic analysis (one-dimensional immunoelectrophoresis ad modum Grabar), crossed immunoelectrophoresis (two-dimensional quantitative immunoelectrophoresis ad modum Clarke and Freeman or ad modum Laurell), rocket-immunoelectrophoresis (one-dimensional quantitative immunoelectrophoresis ad modum Laurell), fused rocket immunoelectrophoresis ad modum Svendsen and Harboe, affinity immunoelectrophoresis ad modum Bøg-Hansen. Methods Immunoelectrophoresis is a general term describing many combinations of the principles of electrophoresis and reaction of antibodies, also known as immunodiffusion. Agarose as 1% gel slabs of about 1 mm thickness buffered at high pH (around 8.6) is traditionally preferred for electrophoresis and the reaction with antibodies. The agarose was chosen as the gel matrix because it has large pores allowing free passage and separation of proteins but provides an anchor for the immunoprecipitates of protein and specific antibodies. The high pH was chosen because antibodies are practically immobile at high pH. Electrophoresis equipment with a horizontal cooling plate was normally recommended for the electrophoresis. Immunoprecipitates are visible in the wet agarose gel, but are stained with protein stains like Coomassie brilliant blue in the dried gel. In contrast to SDS-gel electrophoresis, the electrophoresis in agarose allows native conditions, preserving the native structure and activities of the proteins under investigation, therefore immunoelectrophoresis allows characterization of e
https://en.wikipedia.org/wiki/Pet%20monkey
A pet monkey is a monkey kept as a pet. The practice of keeping monkeys as pets is controversial. Monkeys have often been favorite pets of queens such as Catherine de' Medici and Henrietta Maria, wife of Charles I. Ship's monkeys When the British first began to explore Africa, young monkeys were often captured and taken back on board the ship to entertain sailors. For example, a Senegal monkey was kept as a pet by a ship's cook in the 19th century and entertained passengers with its antics. Some were later kept in zoos; many modern captive monkeys in the UK are descended from such Victorian-era monkeys. The same practice is thought to have occurred during the Napoleonic wars; it is rumored that such practices led to a monkey being washed ashore and hanged in Hartlepool, causing the people of Hartlepool to be nicknamed the Monkey Hangers. As service animals for the disabled Some organizations train capuchin monkeys as monkey helpers to assist quadriplegics and other people with severe spinal cord injuries or mobility impairments. After being socialized in a human home as infants, the monkeys undergo extensive training before being placed with a quadriplegic. Around the house, the monkeys help out by doing tasks such as microwaving food, washing the quadriplegic's face, and opening drink bottles. For safety and the possibility of learning through operant condition methods using positive punishment, the quadriplegics had the ability to deliver a warning tone or 0.5 second shock to the monkey. As with all primates, monkeys must never be fully trusted with a human life in an environment they find demanding or where their needs are not being attended to. In at least one study, the monkey completed all tasks and punishment was used only in the learning stage. In popular culture In popular culture both actual and fictionalized accounts of pet monkeys are utilized extensively. Monkeys are popular in numerous books, television programs, and movies. Sun Wukong (the "Mon
https://en.wikipedia.org/wiki/Cell%20migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals. Errors during this process have serious consequences, including intellectual disability, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. Due to the highly viscous environment (low Reynolds number), cells need to continuously produce forces in order to move. Cells achieve active movement by very different mechanisms. Many less complex prokaryotic organisms (and sperm cells) use flagella or cilia to propel themselves. Eukaryotic cell migration typically is far more complex and can consist of combinations of different migration mechanisms. It generally involves drastic changes in cell shape which are driven by the cytoskeleton. Two very distinct migration scenarios are crawling motion (most commonly studied) and blebbing motility. A paradigmatic example of crawling motion is the case of fish epidermal keratocytes, which have been extensively used in research and teaching. Cell migration studies The migration of cultured cells attached to a surface or in 3D is commonly studied using microscopy. As cell movement is very slow, a few µm/minute, time-lapse microscopy videos are recorded of the migrating cells to speed up the movement. Such videos (Figure 1) reveal that the leading cell front is very active, with a characteristic behavior of successive contractions and expansions. It is generally accepted that the leading front is the main motor that pulls the cell forward. Common features The processes underlying mammal
https://en.wikipedia.org/wiki/TwoOStwo
twoOStwo was a commercial software product developed by Parallels Software Studio (prior to its acquisition by SWsoft). The workstation software consisted of a virtual machine suite for Intel x86-compatible computers which allowed the creation and execution of multiple x86 virtual computers simultaneously. Each virtual machine instance could execute its own guest operating system including Windows, Linux, OS/2 and BSD variants. Description The computer and operating system instance that executes the twoOStwo process is referred to as the host machine. Instances of operating systems running inside a virtual machine are referred to as guest virtual machines. Like an emulator, twoOStwo provides a completely virtualized set of hardware to the guest operating system; for example, irrespective of make and model of the physical network adapter, the guest machine will see a Novell/Eagle NE2000 or Realtek RTL8029(AS) network adapter. twoOStwo virtualizes all devices within the virtual environment, including the video adapter, network adapter, and hard disk adapters. It also provides pass-through drivers for serial and parallel devices. Because all guest virtual machines use the same hardware drivers irrespective of the actual hardware on the host computer, virtual machine instances are highly portable between computers. For example, a running virtual machine can be stopped, copied to another physical computer, and started. Implementation Conventional emulators like Bochs emulate the microprocessor, executing each guest CPU instruction by calling a software subroutine on the host machine that simulates the function of that CPU instruction. This level of abstraction allows the guest machine to run on host machines with a different type of microprocessor, but is also very slow. A more efficient approach consists in software debugger technique. Some parts of the code are executed natively on the real processor; on 'bad' instructions, there are software interrupts that break
https://en.wikipedia.org/wiki/Cockcroft%E2%80%93Walton%20generator
The Cockcroft–Walton (CW) generator, or multiplier, is an electric circuit that generates a high DC voltage from a low-voltage AC or pulsing DC input. It was named after the British and Irish physicists John Douglas Cockcroft and Ernest Thomas Sinton Walton, who in 1932 used this circuit design to power their particle accelerator, performing the first artificial nuclear disintegration in history. They used this voltage multiplier cascade for most of their research, which in 1951 won them the Nobel Prize in Physics for "Transmutation of atomic nuclei by artificially accelerated atomic particles". The circuit was developed in 1919, by Heinrich Greinacher, a Swiss physicist. For this reason, this doubler cascade is sometimes also referred to as the Greinacher multiplier. Cockcroft–Walton circuits are still used in particle accelerators. They also are used in everyday electronic devices that require high voltages, such as X-ray machines, microwave ovens and photocopiers. Operation The CW generator is a voltage multiplier that converts AC or pulsing DC electrical power from a low voltage level to a higher DC voltage level. It is made up of a voltage multiplier ladder network of capacitors and diodes to generate high voltages. Unlike transformers, this method eliminates the requirement for the heavy core and the bulk of insulation/potting required. Using only capacitors and diodes, these voltage multipliers can step up relatively low voltages to extremely high values, while at the same time being far lighter and cheaper than transformers. The biggest advantage of such circuits is that the voltage across each stage of the cascade is equal to only twice the peak input voltage in a half-wave rectifier. In a full-wave rectifier it is three times the input voltage. It has the advantage of requiring relatively low-cost components and being easy to insulate. One can also tap the output from any stage, like in a multi-tapped transformer. To understand the circuit operat
https://en.wikipedia.org/wiki/Windows%20Communication%20Foundation
The Windows Communication Foundation (WCF), previously known as Indigo, is a free and open-source runtime and a set of APIs in the .NET Framework for building connected, service-oriented applications. .NET Core 1.0, released 2016, did not support WCF server side code. WCF support was added to the platform with support for .NET Core 3.1, .NET 5, and .NET 6 in 2022. The architecture WCF is a tool often used to implement and deploy a service-oriented architecture (SOA). It is designed using service-oriented architecture principles to support distributed computing where services have remote consumers. Clients can consume multiple services; services can be consumed by multiple clients. Services are loosely coupled to each other. Services typically have a WSDL interface (Web Services Description Language) that any WCF client can use to consume the service, regardless of which platform the service is hosted on. WCF implements many advanced Web services (WS) standards such as WS-Addressing, WS-ReliableMessaging and WS-Security. With the release of .NET Framework 4.0, WCF also provides RSS Syndication Services, WS-Discovery, routing and better support for REST services. Endpoints A WCF client connects to a WCF service via an endpoint. Each service exposes its contract via one or more endpoints. An endpoint has an address (which is a URL specifying where the endpoint can be accessed) and binding properties that specify how the data will be transferred. The mnemonic "ABC" can be used to remember address/binding/contract. Binding specifies what communication protocols are used to access the service, whether security mechanisms are to be used, and the like. WCF includes predefined bindings for most common communication protocols such as SOAP over HTTP, SOAP over TCP, and SOAP over Message Queues, etc. Interaction between WCF endpoint and client is done using a SOAP envelope. SOAP envelopes are in simple XML form, which makes WCF platform-independent. When a client wants to
https://en.wikipedia.org/wiki/SVISTA
SVISTA (Serenity Virtual Station) is a former commercial virtual machine software product marketed by Serenity Systems International. Windows, OS/2, Linux and FreeBSD hosted versions were available. This product is no longer available nor supported. Description SVISTA was developed under contract with Parallels Software Studio and was based on its existing TwoOStwo software, although the OS/2 and FreeBSD hosted versions were specific to SVISTA. Providing a virtualization product was initially part of Serenity's strategy for marketing its eComStation operating system. When the OS/2 port of Connectix VirtualPC was discontinued following the acquisition of its creator by Microsoft, Serenity contracted Parallels to develop SVISTA as an alternative. A beta program was launched in the spring of 2004, with a general availability release in October of that year. However, the product was discontinued shortly afterwards following the acquisition of Parallels by SWsoft. According to Bob St. John of Serenity Systems, SWsoft was not interested in continuing the development of SVISTA, and withdrew from the OEM contract. Although Serenity briefly expressed interest in finding another solution for an OS/2 hosted virtualization product, it was eventually deemed impractical due to increased competition in the consumer market from Microsoft and VMware. The former product website currently indicates that SVISTA is no longer available, and suggests Virtual Bridges and VirtualBox as possible third-party alternatives. Issues When using SVISTA instances in an environment where MAC addresses are used as unique identifiers (UID), it is advisable to manually configure the MAC address for each virtual machine to ensure each is actually unique. One example of such an environment is one in which MAC security is enabled on switches and another example is an environment in which Altiris products are used (if configured to use the MAC address as the UID). If you are in such a situation, si
https://en.wikipedia.org/wiki/Anti-vibration%20compound
An anti-vibration compound is a temperature-resistant mixture of a liquid with fine particles, which is used to reduce oscillations in calender rolls and to dampen vibrations in fabricated structures like machine beds and housings. Use Vibration may limit the performance of a calender or paper machine. It can have numerous sources such as bulk variations in the sheet, bearing problems, or misalignment of the driveshaft. Vibration manifests itself as a high frequency periodic movement of the roll body with an amplitude from less than one to several µm. When anti-vibration compound is introduced to the center bores of the rolls, vibration is transferred from the solid roll structure to the incompressible fluid component of the anti-vibration compound. Its solid particles are less mobile due to their inertia. Thus the fluid is forced to oscillate around the solid components. The flow energy is absorbed by micro eddies by which the vibration is damped. The benefits are a smoother running with increased operating speed and production, longer operating times of the polymer covers between re-grindings and improved product quality due to the reduction of barring. Classical mechanics
https://en.wikipedia.org/wiki/KXVO
KXVO (channel 15) is a television station in Omaha, Nebraska, United States, airing programming from the digital multicast network TBD. It is owned by Mitts Telecasting Company LLC, which maintains a local marketing agreement (LMA) with the Sinclair Broadcast Group, owner of dual Fox/CW affiliate KPTM (channel 42), for the provision of certain services. Both stations share studios on Farnam Street in Omaha, while KXVO's transmitter is located on Pflug Road, south of Gretna and I-80. History KXVO signed on the air on June 10, 1995 as an affiliate of The WB, which debuted nationally almost five months earlier on January 11 of that year; the station was originally owned by Cocola Broadcasting, but was operated by Pappas Telecasting under a local marketing agreement. In the interim six months, Omaha did have access to The WB via cable and satellite providers through Chicago-based national superstation WGN. Cocola would later sell the station to Mitts Telecasting Company in 2000, which retained the LMA with Pappas. On January 24, 2006, CBS Corporation and Time Warner announced that The WB and UPN would cease broadcasting that September and merge their programming to form a new "fifth" network called The CW. The letters represent the first initials of its corporate parents, CBS (the parent company of UPN) and the Warner Bros. Entertainment unit of Time Warner. In April 2006, KXVO announced an affiliation agreement with The CW, which began airing on the station when the network launched on September 18 of that year. On January 16, 2009, it was announced that several Pappas stations, including sister station KPTM, would be sold to New World TV Group, after the sale received United States bankruptcy court approval. The LMA between KXVO and KPTM continued after the deal was finalized. Titan TV Broadcast Group announced the sale of most of its stations, including KPTM and the LMA with KXVO (which remained under Mitts Telecasting ownership after the sale), to the Sinclair B
https://en.wikipedia.org/wiki/Speech%20transmission%20index
Speech Transmission Index (STI) is a measure of speech transmission quality. The absolute measurement of speech intelligibility is a complex science. The STI measures some physical characteristics of a transmission channel (a room, electro-acoustic equipment, telephone line, etc.), and expresses the ability of the channel to carry across the characteristics of a speech signal. STI is a well-established objective measurement predictor of how the characteristics of the transmission channel affect speech intelligibility. The influence that a transmission channel has on speech intelligibility is dependent on: the speech level frequency response of the channel non-linear distortions background noise level quality of the sound reproduction equipment echos (reflections with delay > 100ms) the reverberation time psychoacoustic effects (masking effects) History The STI was introduced by Tammo Houtgast and Herman Steeneken in 1971, and was accepted by Acoustical Society of America in 1980. Steeneken and Houtgast decided to develop the Speech Transmission Index because they were tasked to carry out a very lengthy series of tedious speech intelligibility measurements for the Netherlands Armed Forces. Instead, they spent the time developing a much quicker objective method (which was actually the predecessor to the STI). Houtgast and Steeneken developed the Speech Transmission Index while working at The Netherlands Organisation of Applied Scientific Research TNO. Their team at TNO kept supporting and developing the STI, improving the model and developing hardware and software for measuring the STI, until 2010. In that year, the TNO research group responsible for the STI spun out of TNO and continued its work as a privately owned company named Embedded Acoustics. Embedded Acoustics now continues to support development of the STI, with Herman Steeneken (now formally retired from TNO) still acting as a senior consultant. In the early years (until approx. 1985) the use
https://en.wikipedia.org/wiki/Subsolar%20point
The subsolar point on a planet is the point at which its Sun is perceived to be directly overhead (at the zenith); that is, where the Sun's rays strike the planet exactly perpendicular to its surface. It can also mean the point closest to the Sun on an astronomical object, even though the Sun might not be visible. To an observer on a planet with an orientation and rotation similar to those of Earth, the subsolar point will appear to move westward with a speed of 1600 km/h, completing one circuit around the globe each day, approximately moving along the equator. However, it will also move north and south between the tropics over the course of a year, so will appear to spiral like a helix. The subsolar point contacts the Tropic of Cancer on the June solstice and the Tropic of Capricorn on the December solstice. The subsolar point crosses the Equator on the March and September equinoxes. Coordinates of the subsolar point The subsolar point moves constantly on the surface of the Earth, but for any given time, its coordinates, or latitude and longitude, can be calculated as follows: where is the latitude of the subsolar point in degrees, is the longitude of the subsolar point in degrees, is the declination of the Sun in degrees, is the Greenwich Mean Time or UTC, in decimal hours since 00:00:00 UTC on the relevant date is the equation of time in minutes. Observation in specific locations Qibla observation by shadows, when the subsolar point passes through the Ka'bah in Saudi Arabia, allowing the Muslim sacred direction to be found by observing shadows. When the point passes through Hawaii, which is the only U.S. state in which this happens, the event is known as Lahaina Noon. See also Subsatellite point
https://en.wikipedia.org/wiki/Sodium%20erythorbate
Sodium erythorbate (C6H7NaO6) is a food additive used predominantly in meats, poultry, and soft drinks. Chemically, it is the sodium salt of erythorbic acid. When used in processed meat such as hot dogs and beef sticks, it increases the rate at which nitrite reduces to nitric oxide, thus facilitating a faster cure and retaining the pink coloring. As an antioxidant structurally related to vitamin C, it helps improve flavor stability and prevents the formation of carcinogenic nitrosamines. When used as a food additive, its E number is E316. The use of erythorbic acid and sodium erythorbate as a food preservative has increased greatly since the U.S. Food and Drug Administration banned the use of sulfites as preservatives in foods intended to be eaten fresh (such as ingredients for fresh salads) and as food processors have responded to the fact that some people are allergic to sulfites. It can also be found in bologna, and is occasionally used in beverages, baked goods, and potato salad. Sodium erythorbate is produced from sugars derived from different sources, such as beets, sugarcane, and corn. Sodium erythorbate is usually produced via a fermentation process from D-glucose by Pseudomonas fluorescens bacteria. Most syntheses proceed through the 2-keto-D-gluconic acid intermediate. An urban myth claims that sodium erythorbate is made from ground earthworms; however, there is no truth to the myth. It is thought that the origin of the legend comes from the similarity of the chemical name to the words earthworm and bait. Alternative applications include the development of additives that could be utilized as antioxidants in general. For instance, this substance has been implemented in the development of corrosion inhibitors for metals and it has been implemented in active packaging. Furthermore, sodium erythorbate's antioxidative properties have been shown to reduce the production thiobarbituric acid reactive substances (TBARS) in frozen meats, effectively increasing t
https://en.wikipedia.org/wiki/Safe%40Office
Safe@Office is a line of firewall and virtual private network (VPN) appliances developed by SofaWare Technologies, a Check Point company. The Check Point Safe@Office product line is targeted at the small and medium business segment, and includes the 500 and 500W (with Wi-Fi) series of internet security appliance. The old S-Box, Safe@Home, 100 series, 200 series, and 400W series are discontinued. The appliances are licensed according to the number of protected IP addresses (referenced to as users) in numbers 5, 25 or unlimited. There is also a variant with a built-in asymmetric disconnection line (ADSL) modem. See also VPN-1 UTM Edge — similar appliance with possibility of being managed from the Check Point SmartCenter.
https://en.wikipedia.org/wiki/Erd%C5%91s%E2%80%93Straus%20conjecture
The Erdős–Straus conjecture is an unproven statement in number theory. The conjecture is that, for every integer that is 2 or more, there exist positive integers , , and for which In other words, the number can be written as a sum of three positive unit fractions. The conjecture is named after Paul Erdős and Ernst G. Straus, who formulated it in 1948, but it is connected to much more ancient mathematics; sums of unit fractions, like the one in this problem, are known as Egyptian fractions, because of their use in ancient Egyptian mathematics. The Erdős–Straus conjecture is one of many conjectures by Erdős, and one of many unsolved problems in mathematics concerning Diophantine equations. Although a solution is not known for all values of , infinitely many values in certain infinite arithmetic progressions have simple formulas for their solution, and skipping these known values can speed up searches for counterexamples. Additionally, these searches need only consider values of that are prime numbers, because any composite counterexample would have a smaller counterexample among its prime factors. Computer searches have verified the truth of the conjecture up to . If the conjecture is reframed to allow negative unit fractions, then it is known to be true. Generalizations of the conjecture to fractions with numerator 5 or larger have also been studied. Background and history When a rational number is expanded into a sum of unit fractions, the expansion is called an Egyptian fraction. This way of writing fractions dates to the mathematics of ancient Egypt, in which fractions were written this way instead of in the more modern vulgar fraction form with a numerator and denominator . The Egyptians produced tables of Egyptian fractions for unit fractions multiplied by two, the numbers that in modern notation would be written , such as the Rhind Mathematical Papyrus table; in these tables, most of these expansions use either two or three terms. These tables were
https://en.wikipedia.org/wiki/Glossitis
Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal surface of the tongue (loss of the lingual papillae), leaving a smooth and erythematous (reddened) surface, (sometimes specifically termed atrophic glossitis). In a wider sense, glossitis can mean inflammation of the tongue generally. Glossitis is often caused by nutritional deficiencies and may be painless or cause discomfort. Glossitis usually responds well to treatment if the cause is identified and corrected. Tongue soreness caused by glossitis is differentiated from burning mouth syndrome, where there is no identifiable change in the appearance of the tongue, and there are no identifiable causes. Symptoms Depending upon what exact meaning of the word glossitis is implied, signs and symptoms might include: Smooth, shiny appearance of the tongue, caused by loss of lingual papillae. Tongue color changes, usually to a darker red color than the normal white-pink color of a healthy tongue. Tongue swelling. Difficulty with chewing, swallowing, or speaking (either because of tongue soreness or tongue swelling). Burning sensation. Some use the term secondary burning mouth syndrome in cases where a detectable cause, such as glossitis, for an oral burning sensation. Depending upon the underlying cause, there may be additional signs and symptoms such as pallor, oral ulceration and angular cheilitis. Causes Anemias Iron-deficiency anemia is mainly caused by blood loss, such as may occur during menses or gastrointestinal hemorrhage. This often results in a depapilled, atrophic glossitis, giving the tongue a bald and shiny appearance, along with pallor (paleness) of the lips and other mucous membranes a tendency towards recurrent oral ulceration, and cheilosis (swelling of the lips). The appearance of the tongue in iron deficiency anemia has been described as diffuse or patchy atrophy with tenderness or burning. One cause of iron deficiency anemia is sideropeni
https://en.wikipedia.org/wiki/Theorem%20on%20friends%20and%20strangers
The theorem on friends and strangers is a mathematical theorem in an area of mathematics called Ramsey theory. Statement Suppose a party has six people. Consider any two of them. They might be meeting for the first time—in which case we will call them mutual strangers; or they might have met before—in which case we will call them mutual acquaintances. The theorem says: In any party of six people, at least three of them are (pairwise) mutual strangers or mutual acquaintances. Conversion to a graph-theoretic setting A proof of the theorem requires nothing but a three-step logic. It is convenient to phrase the problem in graph-theoretic language. Suppose a graph has 6 vertices and every pair of (distinct) vertices is joined by an edge. Such a graph is called a complete graph (because there cannot be any more edges). A complete graph on vertices is denoted by the symbol . Now take a . It has 15 edges in all. Let the 6 vertices stand for the 6 people in our party. Let the edges be coloured red or blue depending on whether the two people represented by the vertices connected by the edge are mutual strangers or mutual acquaintances, respectively. The theorem now asserts: No matter how you colour the 15 edges of a with red and blue, you cannot avoid having either a red triangle—that is, a triangle all of whose three sides are red, representing three pairs of mutual strangers—or a blue triangle, representing three pairs of mutual acquaintances. In other words, whatever colours you use, there will always be at least one monochromatic triangle ( that is, a triangle all of whose edges have the same color ). Proof Choose any one vertex; call it P. There are five edges leaving P. They are each coloured red or blue. The pigeonhole principle says that at least three of them must be of the same colour; for if there are less than three of one colour, say red, then there are at least three that are blue. Let A, B, C be the other ends of these three edges, all of the same
https://en.wikipedia.org/wiki/CB%20military%20symbol
Chemical, biological (CB) — and sometimes radiological — warfare agents were assigned what is termed a military symbol by the U.S. military until the American chemical and biological weapons programs were terminated (in 1990 and 1969, respectively). Military symbols applied to the CB agent fill, and not to the entire weapon. A chemical or biological weapon designation would be, for example, "Aero-14/B", which could be filled with GB, VX, TGB, or with a biological modification kit – OU, NU, UL, etc. A CB weapon is an integrated device of (1) agent, (2) dissemination means, and (3) delivery system. Military symbols can sometimes reflect the name of where a chemical agent is manufactured. For example, chloropicrin has the symbol PS, which was derived from the British town in which it was manufactured during the First World War: Port Sunlight. Chemical agents Blood agents AC – hydrogen cyanide CK – cyanogen chloride SA – Arsine Choking agents BBC – bromobenzyl cyanide CL – chlorine CG – phosgene DP – diphosgene KJ – stannic chloride NC – 80% chloropicrin, 20% stannic chloride PS – chloropicrin Blister agents H – mustard gas HD – distilled mustard gas T – O-Mustard Q – sesquimustard L – Lewisite HL – mustard-lewisite mixture HT – mustard-T mixture HQ – mustard-Q mixture HN – nitrogen mustard ED – ethyl dichloroarsine MD – methyl dichloroarsine PD – phenyl dichloroarsine CX – Phosgene oxime Tear agents CA – camite CN – mace CNB – mace-benzene mixture CNC – mace-chloroform mixture CND CNS – mace-chloropicrin-chloroform mixture CS – CS gas CS1 – micropulverized CS CS2 – microencapsulated CS CR – CR gas CH – Vomiting agents DA – diphenylchlorarsine DC – diphenylcyanoarsine DM – Adamsite Psycho agents BZ – 3-quinuclidinyl benzilate SN – sernyl (PCP) K – lysergic acid diethylamide (LSD) [EA 1729] Nerve agents GA – tabun [EA1205] GB – sarin [EA1208] GB2 – sarin as a binary agent from mixing OPA (isopropyl alcohol+isopropyl amine) + DF [EA5823] GD – soman [EA12
https://en.wikipedia.org/wiki/Residual%20gas%20analyzer
A residual gas analyzer (RGA) is a small and usually rugged mass spectrometer, typically designed for process control and contamination monitoring in vacuum systems. When constructed as a quadrupole mass analyzer, there exist two implementations, utilizing either an open ion source (OIS) or a closed ion source (CIS). RGAs may be found in high vacuum applications such as research chambers, surface science setups, accelerators, scanning microscopes, etc. RGAs are used in most cases to monitor the quality of the vacuum and easily detect minute traces of impurities in the low-pressure gas environment. These impurities can be measured down to Torr levels, possessing sub-ppm detectability in the absence of background interferences. RGAs would also be used as sensitive in-situ leak detectors commonly using helium, isopropyl alcohol or other tracer molecules. With vacuum systems pumped down to lower than Torr—checking of the integrity of the vacuum seals and the quality of the vacuum—air leaks, virtual leaks and other contaminants at low levels may be detected before a process is initiated. Open ion source OIS is the most widely available type of RGA. Residual Gas Analyzers measure pressure by sensing the weight of each atom as they pass through the quadrupole. Cylindrical and axially symmetrical, this kind of ionizer has been around since the early 1950s. The OIS type is usually mounted directly to the vacuum chamber, exposing the filament wire and anode wire cage to the surrounding vacuum chamber, allowing all molecules in the vacuum chamber to move easily through the ion source. With a maximum operating pressure of Torr and a minimum detectable partial pressure as low as Torr when used in tandem with an electron multiplier. OIS RGAs measure residual gas levels without affecting the gas composition of their vacuum environment, though there are performance limitations which include: Outgassing of water from the chamber, from the OIS electrodes and most varie
https://en.wikipedia.org/wiki/Verifiable%20random%20function
In cryptography, a verifiable random function (VRF) is a public-key pseudorandom function that provides proofs that its outputs were calculated correctly. The owner of the secret key can compute the function value as well as an associated proof for any input value. Everyone else, using the proof and the associated public key (or verification key), can check that this value was indeed calculated correctly, yet this information cannot be used to find the secret key. A verifiable random function can be viewed as a public-key analogue of a keyed cryptographic hash and as a cryptographic commitment to an exponentially large number of seemingly random bits. The concept of a verifiable random function is closely related to that of a verifiable unpredictable function (VUF), whose outputs are hard to predict but do not necessarily seem random. The concept of a VRF was introduced by Micali, Rabin, and Vadhan in 1999. Since then, verifiable random functions have found widespread use in cryptocurrencies, as well as in proposals for protocol design and cybersecurity. Constructions In 1999, Micali, Rabin, and Vadhan introduced the concept of a VRF and proposed the first such one. The original construction was rather inefficient: it first produces a verifiable unpredictable function, then uses a hard-core bit to transform it into a VRF; moreover, the inputs have to be mapped to primes in a complicated manner: namely, by using a prime sequence generator that generates primes with overwhelming probability using a probabilistic primality test. The verifiable unpredictable function thus proposed, which is provably secure if a variant of the RSA problem is hard, is defined as follows: The public key PK is , where m is the product of two random primes, r is a number randomly selected from , coins is a randomly selected set of bits, and Q a function selected randomly from all polynomials of degree over the field . The secret key is . Given an input x and a secret key SK, the VUF use
https://en.wikipedia.org/wiki/Membrane-introduction%20mass%20spectrometry
Membrane-introduction mass spectrometry (MIMS) is a method of introducing analytes into the mass spectrometer's vacuum chamber via a semi-permeable membrane. Usually a thin, gas-permeable, hydrophobic membrane is used, for example polydimethylsiloxane. Samples can be almost any fluid including water, air or sometimes even solvents. The great advantage of the method of sample introduction is its simplicity. MIMS can be used to measure a variety of analytes in real-time, with little or no sample preparation. MIMS is most useful for the measurement of small, non-polar molecules, since molecules of this type have a greater affinity for the membrane material than the sample. The advantage of this method is that complex samples that cannot diffuse through the membrane are not incorporated into the mass spectroscopic measurements, highlighting the simplicity of only analyzing (small) molecules of interest. See also Atmospheric pressure chemical ionization Liquid chromatography-mass spectrometry
https://en.wikipedia.org/wiki/Complexor
The word complexor was coined by Marcial Losada derived from the words "complex order", to refer to chaotic attractors that are strange and thus have fractal structure (in contrast to fixed point or limit cycle attractors). Losada claimed that these trajectories reflect the creativity and innovation that characterize high performance teams, while in contrast, low performance teams have trajectories in phase space that approach the limiting dynamics of point attractors. The modeling behind this claim has been strongly criticised for flawed methodology and as an invalid application of Lorenz equations by Brown et al. and by Andrés Navas.
https://en.wikipedia.org/wiki/Baxter%20International
Baxter International Inc. is an American multinational healthcare company with headquarters in Deerfield, Illinois. The company primarily focuses on products to treat kidney disease, and other chronic and acute medical conditions. The company had 2017 sales of $10.6 billion, across two businesses: BioScience and Medical Products. Baxter's BioScience business produces recombinant and blood plasma proteins to treat hemophilia and other bleeding disorders; plasma-based therapies to treat immune deficiencies and other chronic and acute blood-related conditions; products for regenerative medicine, and vaccines. Baxter's Medical Products business produces intravenous products and other products used in the delivery of fluids and drugs to patients; inhalational anaesthetics; contract manufacturing services; and products to treat end-stage kidney disease, or irreversible kidney failure, including products for peritoneal dialysis and hemodialysis. History Baxter International was founded in 1931 by Donald Baxter, a Los Angeles-based medical doctor, as a manufacturer and distributor of intravenous therapy solutions. Seeing a need for products closer to the Midwest, the company opened a manufacturing plant in Glenview, Illinois, in 1933. Baxter's interest was bought out in 1935 by Ralph Falk, who established a research and development function. In 1939 the company developed a vacuum-type collection container, extending the shelf life of blood from hours to weeks. In 1954, the company expanded operations outside of the United States by opening an office in Belgium. In 1956 Baxter International introduced the first functioning artificial kidney, and in 1971 became a member of the Fortune 500. In 1971, Baxter built a major manufacturing plant in Ashdod, Israel, and as a result, the company was placed on the Arab League boycott list in the early 1980s. Throughout the 1980s and 1990s the company expanded to deliver a wider variety of products and services (including vaccines,
https://en.wikipedia.org/wiki/Tribrach%20%28instrument%29
A tribrach is an attachment plate used to attach a surveying instrument, for example a theodolite, total station, GNSS antenna or target to a tripod. A tribrach allows the survey instrument to be repeatedly placed in the same position over a surveying marker point with sub-millimetre precision, by loosening and re-tightening a lock to adjust the instrument base in a horizontal plane. Components of a tribrach The device consists of two triangular metal plates connected at their corners by leveling thumbscrews, a bubble level, a locking mechanism and often an optical plummet. The centre of the bottom plate of the tribrach has a 5/8-11 UNC thread bolt hole which is used to attach the tribrach to the tripod. The top plate has three small holes or slots spaced 120˚ apart above leveling thumbscrews, and a locking mechanism which enables a survey instrument or target to be accurately placed on the tribrach and locked in place. The optical plummet has either a bullseye or cross hair sight for positioning the instrument over a survey marker or ground control point. The older tribrachs required a plumb line to allow them to be positioned vertically over a point and took longer to set up. Some modern total stations have an integral laser plummet built in. Using a tribrach The process is iterative between horizontal position and top plate level, because they are interactive. The following general process is followed: The tribrach is attached to the tripod and placed over the marker. Looking through the optical plummet pick up two of the tripod legs and position the cross hairs over the marker. Tread all three legs into the grass, bitumen, concrete. Look through the optical plummet and using the thumbscrews put the cross hairs back over the marker. Adjust the level of the tribrach by slackening the tripod screws and sliding the legs. Re-center the cross hairs using the thumb screws, then fine-tune the level using the tripod legs. Once the tribrach is nearly cen
https://en.wikipedia.org/wiki/ACPI
Advanced Configuration and Power Interface (ACPI) is an open standard that operating systems can use to discover and configure computer hardware components, to perform power management (e.g. putting unused hardware components to sleep), auto configuration (e.g. Plug and Play and hot swapping), and status monitoring. First released in December 1996, ACPI aims to replace Advanced Power Management (APM), the MultiProcessor Specification, and the Plug and Play BIOS (PnP) Specification. ACPI brings power management under the control of the operating system, as opposed to the previous BIOS-centric system that relied on platform-specific firmware to determine power management and configuration policies. The specification is central to the Operating System-directed configuration and Power Management (OSPM) system. ACPI defines hardware abstraction interfaces between the device's firmware (e.g. BIOS, UEFI), the computer hardware components, and the operating systems. Internally, ACPI advertises the available components and their functions to the operating system kernel using instruction lists ("methods") provided through the system firmware (UEFI or BIOS), which the kernel parses. ACPI then executes the desired operations written in ACPI Machine Language (such as the initialization of hardware components) using an embedded minimal virtual machine. Intel, Microsoft and Toshiba originally developed the standard, while HP, Huawei and Phoenix also participated later. In October 2013, ACPI Special Interest Group (ACPI SIG), the original developers of the ACPI standard, agreed to transfer all assets to the UEFI Forum, in which all future development will take place. of the standard 6.5 was released in August 2022. Architecture The firmware-level ACPI has three main components: the ACPI tables, the ACPI BIOS, and the ACPI registers. The ACPI BIOS generates ACPI tables and loads ACPI tables into main memory. Much of the firmware ACPI functionality is provided in bytecode of ACP
https://en.wikipedia.org/wiki/Mass%20flow%20sensor
A mass (air) flow sensor (MAF) is a sensor used to determine the mass flow rate of air entering a fuel-injected internal combustion engine. The air mass information is necessary for the engine control unit (ECU) to balance and deliver the correct fuel mass to the engine. Air changes its density with temperature and pressure. In automotive applications, air density varies with the ambient temperature, altitude and the use of forced induction, which means that mass flow sensors are more appropriate than volumetric flow sensors for determining the quantity of intake air in each cylinder. There are two common types of mass airflow sensors in use on automotive engines. These are the vane meter and the hot wire. Neither design employs technology that measures air mass directly. However, with additional sensors and inputs, an engine's ECU can determine the mass flow rate of intake air. Both approaches are used almost exclusively on electronic fuel injection (EFI) engines. Both sensor designs output a 0.0–5.0 volt or a pulse-width modulation (PWM) signal that is proportional to the air mass flow rate, and both sensors have an intake air temperature (IAT) sensor incorporated into their housings for most post on-board diagnostics (OBDII) vehicles. Vehicles prior to 1996 could have MAF without an IAT. An example is 1994 Infiniti Q45. When a MAF sensor is used in conjunction with an oxygen sensor, the engine's air/fuel ratio can be controlled very accurately. The MAF sensor provides the open-loop controller predicted air flow information (the measured air flow) to the ECU, and the oxygen sensor provides closed-loop feedback in order to make minor corrections to the predicted air mass. Also see manifold absolute pressure sensor (MAP sensor). Since around 2012, some MAF sensors include a humidity sensor. Moving vane meter The VAF (volume air flow) sensor measures the air flow into the engine with a spring-loaded air vane (flap/door) attached to a variable resistor (potentio
https://en.wikipedia.org/wiki/Bouillon%20cube
A bouillon cube (Canada and US), stock cube (Australia, Ireland, New Zealand, South Africa and UK), or broth cube (Asia) is dehydrated broth or stock formed into a small cube or other cuboid shape. The most common format is a cube about wide. It is typically made from dehydrated vegetables or meat stock, a small portion of fat, MSG, salt, and seasonings, shaped into a small cube. Vegetarian and vegan types are also made. Bouillon is also available in granular, powdered, liquid, and paste forms. History Dehydrated meat stock, in the form of tablets, was known in the 17th century to English food writer Anne Blencowe, who died in 1718, and elsewhere as early as 1735. Various French cooks in the early 19th century (Lefesse, Massué, and Martin) tried to patent bouillon cubes and tablets, but were turned down for lack of originality. Nicolas Appert also proposed such dehydrated bouillon in 1831. Portable soup was a kind of dehydrated food used in the 18th and 19th centuries. It was a precursor of meat extract and bouillon cubes, and of industrially dehydrated food. It is also known as pocket soup or veal glue. It is a cousin of the glace de viande of French cooking. It was long a staple of seamen and explorers, for it would keep for many months or even years. In this context, it was a filling and nutritious dish. Portable soup of less extended vintage was, according to the 1881 Household Cyclopedia, "exceedingly convenient for private families, for by putting one of the cakes in a saucepan with about a quart of water, and a little salt, a basin of good broth may be made in a few minutes." In the mid-19th century, German chemist Justus von Liebig developed meat extract, but it was more expensive than bouillon cubes. The invention of the bouillon cube is also attributed to Auguste Escoffier, one of the most accomplished French chefs of his time, who also pioneered many other advances in food preservation, such as the canning of tomatoes and vegetables. Industrially
https://en.wikipedia.org/wiki/Variable-frequency%20transformer
A variable-frequency transformer (VFT) is used to transmit electricity between two (asynchronous or synchronous) alternating current frequency domains. The VFT is a relatively recent development. Most asynchronous grid inter-ties use high-voltage direct current converters, while synchronous grid inter-ties are connected by lines and "ordinary" transformers, but without the ability to control power flow between the systems, or with phase-shifting transformer with some flow control. It can be thought of as a very high power synchro, or a rotary converter acting as a frequency changer, which is more efficient than a motor–generator of the same rating. Construction and operation A variable-frequency transformer is a doubly fed electric machine resembling a vertical shaft hydroelectric generator with a three-phase wound rotor, connected by slip rings to one external power circuit. The stator is connected to the other. With no applied torque, the shaft rotates due to the difference in frequency between the networks connected to the rotor and stator. A direct-current torque motor is mounted on the same shaft; changing the direction of torque applied to the shaft changes the direction of power flow. The variable-frequency transformer behaves as a continuously adjustable phase-shifting transformer. It allows control of the power flow between two networks. Unlike power electronics solutions such as back-to-back HVDC, the variable frequency transformer does not demand harmonic filters and reactive power compensation. Limitations of the concept are the current-carrying capacity of the slip rings for the rotor winding. Projects Five small variable-frequency transformer with a total power rate of 25 MVA were in use at Neuhof Substation, Bad Sachsa, Germany for coupling power grids of former East and West Germany between 1985 and 1990. Langlois Substation in Québec, Canada () installed a 100 MW variable-frequency transformer in 2004 to connect the asynchronous grids in Québe
https://en.wikipedia.org/wiki/Preferred%20frame
In theoretical physics, a preferred frame or privileged frame is usually a special hypothetical frame of reference in which the laws of physics might appear to be identifiably different (simpler) from those in other frames. In theories that apply the principle of relativity to inertial motion, physics is the same in all inertial frames, and is even the same in all frames under the principle of general relativity. Preferred frame in aether theory In theories that presume that light travels at a fixed speed relative to an unmodifiable and detectable luminiferous aether, a preferred frame would be a frame in which this aether would be stationary. In 1887, Michelson and Morley tried to identify the state of motion of the aether. To do so, they assumed Galilean relativity to be satisfied by clocks and rulers; that is, that the length of rulers and periods of clocks are invariant under any Galilean frame change. Under such an hypothesis, the aether should have been observed. By comparing measurements made in different directions and looking for an effect due to the Earth's orbital speed, their experiment famously produced a null result. As a consequence, within Lorentz ether theory the Galilean transformation was replaced by the Lorentz transformation. However, in Lorentz aether theory the existence of an undetectable aether is assumed and the relativity principle holds. The theory was quickly replaced by special relativity, which gave similar formulas without the existence of an unobservable aether. All inertial frames are physically equivalent, in both theories. More precisely, provided that no phenomenon violates the principle of relativity of motion, there is no means to measure the velocity of an inertial observer with regard to a possible medium of propagation of quantum waves. Inertial frames preferred above noninertial frames Although all inertial frames are equivalent under classical mechanics and special relativity, the set of all inertial frames is priv
https://en.wikipedia.org/wiki/Comparison%20of%20Unicode%20encodings
This article compares Unicode encodings. Two situations are considered: 8-bit-clean environments (which can be assumed), and environments that forbid use of byte values that have the high bit set. Originally such prohibitions were to allow for links that used only seven data bits, but they remain in some standards and so some standard-conforming software must generate messages that comply with the restrictions. Standard Compression Scheme for Unicode and Binary Ordered Compression for Unicode are excluded from the comparison tables because it is difficult to simply quantify their size. Compatibility issues A UTF-8 file that contains only ASCII characters is identical to an ASCII file. Legacy programs can generally handle UTF-8 encoded files, even if they contain non-ASCII characters. For instance, the C printf function can print a UTF-8 string, as it only looks for the ASCII '%' character to define a formatting string, and prints all other bytes unchanged, thus non-ASCII characters will be output unchanged. UTF-16 and UTF-32 are incompatible with ASCII files, and thus require Unicode-aware programs to display, print and manipulate them, even if the file is known to contain only characters in the ASCII subset. Because they contain many zero bytes, the strings cannot be manipulated by normal null-terminated string handling for even simple operations such as copy. Therefore, even on most UTF-16 systems such as Windows and Java, UTF-16 text files are not common; older 8-bit encodings such as ASCII or ISO-8859-1 are still used, forgoing Unicode support; or UTF-8 is used for Unicode. One rare counter-example is the "strings" file used by macOS (Mac OS X 10.3 Panther and later) applications for lookup of internationalized versions of messages which defaults to UTF-16, with "files encoded using UTF-8 ... not guaranteed to work." XML is, by convention, encoded as UTF-8, and all XML processors must at least support UTF-8 (including US-ASCII by definition) and UTF-16. Ef
https://en.wikipedia.org/wiki/Guidonian%20hand
The Guidonian hand was a mnemonic device used to assist singers in learning to sight-sing. Some form of the device may have been used by Guido of Arezzo, a medieval music theorist who wrote a number of treatises, including one instructing singers in sightreading. The hand occurs in some manuscripts before Guido's time as a tool to find the semitone; it does not have the depicted form until the 12th century. Sigebertus Gemblacensis in 1105–1110 did describe Guido using the joints of the hand to aid in teaching his hexachord. The Guidonian hand is closely linked with Guido's new ideas about how to learn music, including the use of hexachords, and the first known Western use of solfège. Theory The idea of the Guidonian hand is that each portion of the hand represents a specific note within the hexachord system, which spans nearly three octaves from "Γ ut" (that is, "Gamma ut") (the contraction of which is "Gamut", which can refer to the entire span) to "E la" (in other words, from the G at the bottom of the modern bass clef to the E at the top of the treble clef). The compound names combine the tone's pitch letter and up to three hexachordal syllables to indicate the functions of each note. These compound names were sometimes rendered with spaces between the pitch letter and the syllables, but in prose were also sometimes combined into one word, adding an "e" after the pitch letter if it was a consonant, yielding the names indicated in the chart below. Some of the compound names clarify the register (for example, C fa ut, C sol fa ut, and C sol fa indicate three different octaves of C), but there are also some names that repeat (for instance, the same name B mi appears in three different octaves). In teaching, an instructor would indicate a series of notes for their students to sing by pointing to them on their hand, similar to the system of hand signals sometimes used in conjunction with solfège. Commonly, as in the example below, the notes of the gamut were menta
https://en.wikipedia.org/wiki/MP6
The Rise mP6 was a superpipelined and superscalar microprocessor designed by Rise Technology to compete with the Intel Pentium line. History Rise Technology had spent 5 years developing a x86 compatible microprocessor, and finally introduced it in November 1998 as a low-cost, low-power alternative for the Super Socket 7 platform, that allowed for higher Front-side bus speeds than the previous Socket 7 and that made it possible for other CPU manufacturers to keep competing against Intel, that had moved to the Slot 1 platform. Design The mP6 made use of the MMX instruction set and had three MMX pipelines which allowed the CPU to execute up to three MMX instructions in a single cycle. Its three integer units made it possible to execute three integer instructions in a single cycle as well and the fully pipelined floating point unit could execute up to two floating-point instructions per cycle. To further improve the performance the core utilized branch prediction and a number of techniques to resolve data dependency conflicts. According to Rise, the mP6 should perform almost as fast as Intel Pentium II at the same frequencies. Performance Despite its innovative features, the real-life performance of the mP6 proved disappointing. This was mainly due to the small L1 Cache. Another reason was that the Rise mP6's PR 266 rating was based upon the old Intel Pentium MMX, while its main competitors were the Intel Celeron 266, the IDT WinChip 2-266 and the AMD K6-2 266, that all delivered more performance in most benchmarks and applications. The Celeron and the K6-2 actually worked at 266 MHz, and the WinChip 2's PR rating was based upon the performance of its AMD opponent. Use Announced in 1998, the chip never achieved widespread use, and Rise quietly exited the market in December of the following year. Like competitors Cyrix and IDT, Rise found it was unable to compete with Intel and AMD. Legacy Silicon Integrated Systems (SiS) licensed the mP6 technology, and used it
https://en.wikipedia.org/wiki/Local%20reference%20frame
In theoretical physics, a local reference frame (local frame) refers to a coordinate system or frame of reference that is only expected to function over a small region or a restricted region of space or spacetime. The term is most often used in the context of the application of local inertial frames to small regions of a gravitational field. Although gravitational tidal forces will cause the background geometry to become noticeably non-Euclidean over larger regions, if we restrict ourselves to a sufficiently small region containing a cluster of objects falling together in an effectively uniform gravitational field, their physics can be described as the physics of that cluster in a space free from explicit background gravitational effects. Equivalence principle When constructing his general theory of relativity, Einstein made the following observation: a freely falling object in a gravitational field will not be able to detect the existence of the field by making local measurements ("a falling man feels no gravity"). Einstein was then able to complete his general theory by arguing that the physics of curved spacetime must reduce over small regions to the physics of simple inertial mechanics (in this case special relativity) for small freefalling regions. Einstein referred to this as "the happiest idea of my life". Laboratory frame In physics, the laboratory frame of reference, or lab frame for short, is a frame of reference centered on the laboratory in which the experiment (either real or thought experiment) is done. This is the reference frame in which the laboratory is at rest. Also, this is usually the frame of reference in which measurements are made, since they are presumed (unless stated otherwise) to be made by laboratory instruments. An example of instruments in a lab frame, would be the particle detectors at the detection facility of a particle accelerator. See also Breit frame Center-of-mass frame Frame bundle Inertial frame of reference Local coo
https://en.wikipedia.org/wiki/Isaak%20Khalatnikov
Isaak Markovich Khalatnikov (, ; 17 October 1919 – 9 January 2021) was a leading Soviet theoretical physicist who made significant contributions to many areas of theoretical physics, including general relativity, quantum field theory, as well as the theory of quantum liquids. He is well known for his role in developing the Landau-Khalatnikov theory of superfluidity and the so-called BKL conjecture in the general theory of relativity. Life and career Isaak Khalatnikov was born into a Ukrainian Jewish family in Yekaterinoslav (now Dnipro, Ukraine) and graduated from Dnipropetrovsk State University with a degree in Physics in 1941. He had been a member of the Communist Party since 1944. He earned his doctorate in 1952. His wife Valentina was the daughter of Revolutionary hero Mykola Shchors. Much of Khalatnikov's research was a collaboration with, or inspired by, Lev Landau, including the Landau-Khalatnikov theory of superfluidity. During 1969 he briefly worked as a part-time professor of theoretical physics at Leiden University. In 1970, inspired by the mixmaster model introduced by Charles W. Misner, then at Princeton University, Khalatnikov, together with Vladimir Belinski and Evgeny Lifshitz, introduced what has become known as the BKL conjecture, which is widely regarded as one of the most outstanding open problems in the classical theory of gravitation. Khalatnikov directed the Landau Institute for Theoretical Physics in Moscow from 1965 to 1992. He was elected to the Academy of Sciences of the Soviet Union in 1984. He has been awarded the Landau Gold Medal, the Humboldt Prize, and the Marcel Grossmann Award. He was also a foreign member of the Royal Society of London. He was portrayed by actor Georg Nikoloff in the film The Theory of Everything. Khalatnikov died in Chernogolovka on 9 January 2021, aged 101. Honours and awards Order "For Merit to the Fatherland", 3rd class (1999) Order of Alexander Nevsky (2020) Order of the October Revolution (1986)
https://en.wikipedia.org/wiki/Non-inertial%20reference%20frame
A non-inertial reference frame (also known as an accelerated reference frame) is a frame of reference that undergoes acceleration with respect to an inertial frame. An accelerometer at rest in a non-inertial frame will, in general, detect a non-zero acceleration. While the laws of motion are the same in all inertial frames, in non-inertial frames, they vary from frame to frame depending on the acceleration. In classical mechanics it is often possible to explain the motion of bodies in non-inertial reference frames by introducing additional fictitious forces (also called inertial forces, pseudo-forces and d'Alembert forces) to Newton's second law. Common examples of this include the Coriolis force and the centrifugal force. In general, the expression for any fictitious force can be derived from the acceleration of the non-inertial frame. As stated by Goodman and Warner, "One might say that F ma holds in any coordinate system provided the term 'force' is redefined to include the so-called 'reversed effective forces' or 'inertia forces'." In the theory of general relativity, the curvature of spacetime causes frames to be locally inertial, but globally non-inertial. Due to the non-Euclidean geometry of curved space-time, there are no global inertial reference frames in general relativity. More specifically, the fictitious force which appears in general relativity is the force of gravity. Avoiding fictitious forces in calculations In flat spacetime, the use of non-inertial frames can be avoided if desired. Measurements with respect to non-inertial reference frames can always be transformed to an inertial frame, incorporating directly the acceleration of the non-inertial frame as that acceleration as seen from the inertial frame. This approach avoids use of fictitious forces (it is based on an inertial frame, where fictitious forces are absent, by definition) but it may be less convenient from an intuitive, observational, and even a calculational viewpoint. As point
https://en.wikipedia.org/wiki/Memory%20map
In computer science, a memory map is a structure of data (which usually resides in memory itself) that indicates how memory is laid out. The term "memory map" has different meanings in different contexts. It is the fastest and most flexible cache organization that uses an associative memory. The associative memory stores both the address and content of the memory word. In the boot process of some computers, a memory map may be passed on from the firmware to instruct an operating system kernel about memory layout. It contains the information regarding the size of total memory, any reserved regions and may also provide other details specific to the architecture. In virtual memory implementations and memory management units, a memory map refers to page tables or hardware registers, which store the mapping between a certain process's virtual memory layout and how that space relates to physical memory addresses. In native debugger programs, a memory map refers to the mapping between loaded executable(or)library files and memory regions. These memory maps are used to resolve memory addresses (such as function pointers) to actual symbols. PC BIOS memory map BIOS for the IBM Personal Computer and compatibles provides a set of routines that can be used by operating system or applications to get the memory layout. Some of the available routines are: BIOS Function: INT 0x15, AX=0xE801: This BIOS interrupt call is used to get the memory size for 64MB+ configurations. It is supported by AMI BIOSses dated August 23, 1994 or later. The caller sets AX to 0xE801 then executes int 0x15. If some error has happened, the routine returns with CF (Carry Flag) set to 1. If no error, the routine returns with CF clear and the state of registers is described as following: BIOS Function: INT 0x15, AX=0xE820 - GET SYSTEM MEMORY MAP: Input: SMAP buffer structure: How used: The operating system shall allocate an SMAP buffer in memory (20 bytes buffer). Then set registers as specified in "I
https://en.wikipedia.org/wiki/SAPHO%20syndrome
SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes. These diseases share some clinical, radiologic, and pathologic characteristics. An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972. Subsequently, in 1978, several cases of were associated with blisters on the palms and soles (palmoplantar pustulosis). Since then, a number of associations between skin conditions and osteoarticular disorders have been reported under a variety of names, including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy. The term SAPHO (an acronym for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined in 1987 to represent this spectrum of inflammatory bone disorders that may or may not be associated with dermatologic pathology. Diagnosis Radiologic findings Anterior chest wall (most common site, 65–90% of patients): Hyperostosis, sclerosis and bone hypertrophy especially involving the sternoclavicular joint, often with a soft tissue component. Spine (33% of patients): Segmental, usually involving the thoracic spine. The four main presentations include spondylodiscitis, osteosclerosis, paravertebral ossifications, and sacroiliac joint involvement. Long bones (30% of patients): usually metadiaphyseal and located in the distal femur and proximal tibia. It looks like chronic osteomyelitis but will not have a sequestrum or abscess. Flat bones (10% of patients): mandible and ilium. Peripheral arthritis has been reported in 92% of cases of SAPHO as well. In children, the SAPHO syndrome is most likely to affect the metaphysis of long bones in the legs (tibia, femur, fibula), followed by clavicles and spine. Treatment Bisphosphonate therapy has been suggested as a first-line therapeutic option in many case reports and series. Treatment with tumor necrosis factor alpha antagonists (TNF inhibitors) has been tried in a few
https://en.wikipedia.org/wiki/Fictitious%20play
In game theory, fictitious play is a learning rule first introduced by George W. Brown. In it, each player presumes that the opponents are playing stationary (possibly mixed) strategies. At each round, each player thus best responds to the empirical frequency of play of their opponent. Such a method is of course adequate if the opponent indeed uses a stationary strategy, while it is flawed if the opponent's strategy is non-stationary. The opponent's strategy may for example be conditioned on the fictitious player's last move. History Brown first introduced fictitious play as an explanation for Nash equilibrium play. He imagined that a player would "simulate" play of the game in their mind and update their future play based on this simulation; hence the name fictitious play. In terms of current use, the name is a bit of a misnomer, since each play of the game actually occurs. The play is not exactly fictitious. Convergence properties In fictitious play, strict Nash equilibria are absorbing states. That is, if at any time period all the players play a Nash equilibrium, then they will do so for all subsequent rounds. (Fudenberg and Levine 1998, Proposition 2.1) In addition, if fictitious play converges to any distribution, those probabilities correspond to a Nash equilibrium of the underlying game. (Proposition 2.2) Therefore, the interesting question is, under what circumstances does fictitious play converge? The process will converge for a 2-person game if: Both players have only a finite number of strategies and the game is zero sum (Robinson 1951) The game is solvable by iterated elimination of strictly dominated strategies (Nachbar 1990) The game is a potential game (Monderer and Shapley 1996-a,1996-b) The game has generic payoffs and is 2 × N (Berger 2005) Fictitious play does not always converge, however. Shapley (1964) proved that in the game pictured here (a nonzero-sum version of Rock, Paper, Scissors), if the players start by choosing (
https://en.wikipedia.org/wiki/Incontinence%20pad
An incontinence pad is a small, impermeable multi-layered sheet with high absorbency that is used in the incontinence and health-care industries as a precaution against fecal or urinary incontinence. It is generally made of cotton if washable, or paper if disposable. Incontinence diapers (or incontinence nappies) are a common incontinence pad. Incontinence pads are usually placed in an undergarment or on a bed or chair under a person. Incontinence pads are manufactured in light and heavy grades which offer a range of absorbencies, often referred to as a 'working capacity', which refers to the true absorbency an incontinence pad offers when in use. These sorts of pads can come as panty-liners, inserts, pads or even available as replacement underwear. In the UK, chair or bed-based protective pads, known as chair pads or bed pads, are commonly used in healthcare settings where incontinence may be an issue. They are usually constructed in layers of quilted absorbent fabric and alternating liquid impermeable plastic or polyurethane. Products containing polyurethane are generally considered better as they provide a waterproof backing, whilst still allowing air to circulate reducing the risk of rashes and sores. Healthcare Incontinence pads are often overused in people with dementia. Guidelines suggest that treatment should always be preferred to containment as pads can be uncomfortable and negatively affect the person's dignity. A balanced diet, exercise, hand hygiene, and prompts to go to the toilet should be preferred over using pads. An ethnographic study in the UK pointed out the existence of "pad culture" which means that the main care strategy was the use of continence pads even in cases where people were continent. The main reasons for this strategy were fears about safety and falls which kept people in their beds and did not support independence. This mode of caring often leads to undignified situations and the use of demeaning language. See also Adult diaper
https://en.wikipedia.org/wiki/Spin%20coating
Spin coating is a procedure used to deposit uniform thin films onto flat substrates. Usually a small amount of coating material is applied on the center of the substrate, which is either spinning at low speed or not spinning at all. The substrate is then rotated at speeds up to 10,000 rpm to spread the coating material by centrifugal force. A machine used for spin coating is called a spin coater, or simply spinner. Rotation is continued while the fluid spins off the edges of the substrate, until the desired thickness of the film is achieved. The applied solvent is usually volatile, and simultaneously evaporates. The higher the angular speed of spinning, the thinner the film. The thickness of the film also depends on the viscosity and concentration of the solution, and the solvent. Pioneering theoretical analysis of spin coating was undertaken by Emslie et al., and has been extended by many subsequent authors (including Wilson et al., who studied the rate of spreading in spin coating; and Danglad-Flores et al., who found a universal description to predict the deposited film thickness). Spin coating is widely used in microfabrication of functional oxide layers on glass or single crystal substrates using sol-gel precursors, where it can be used to create uniform thin films with nanoscale thicknesses. It is used intensively in photolithography, to deposit layers of photoresist about 1 micrometre thick. Photoresist is typically spun at 20 to 80 revolutions per second for 30 to 60 seconds. It is also widely used for the fabrication of planar photonic structures made of polymers. One advantage to spin coating thin films is the uniformity of the film thickness. Owing to self-leveling, thicknesses do not vary more than 1%. The thickness of films produced in this manner may also affect the optical properties of such materials. This is important for electrochemical testing, specifically when recording absorbance readings from Ultraviolet-visible Spectroscopy, since thicker
https://en.wikipedia.org/wiki/Mielie%20meal
Mielie meal, also known as mealie meal or maize meal, is a relatively coarse flour (much coarser than cornflour or cornstarch) made from maize or mealies in Southern Africa, from the Portuguese milho. It is also known by various other indigenous language names depending on the locality or country. It was originally brought to Africa from the Americas by the Portuguese. It is a food that was originally eaten by the Voortrekkers during The Great Trek, but has become the staple diet of most Southern African countries. Because of its ability to be stored without refrigeration, it is cheap and abundant in all shops and markets. It is a staple food in South Africa, Mozambique, Lesotho, Eswatini, Zambia, Zimbabwe, Malawi, Botswana and many other parts of Southern Africa, traditionally made into uphuthu, Unga (Nshima), sour-milk porridge, pap, Munkoyo, and also umqombothi and Chibwantu (types of beer). Pap and phutu The raw ingredient of mielie meal is added to boiling water, the ratio of which produces either porridge or the firmer pap/nshima/sadza. When making porridge, milk is sometimes used to produce a creamier dish. The porridge usually has a thick texture and is commonly eaten for breakfast in southern Africa. The firmer pap is eaten with meat and gravy dishes as well as vegetable relishes. It is similar to Italian polenta except that, like grits in the Southern United States, it is usually made of a white rather than a yellow maize variety. Nutrition Mealie meal contains carbohydrates, protein, fat and fiber. See also Cornmeal Grits Sadza Samp List of maize dishes
https://en.wikipedia.org/wiki/CASTEP
CASTEP is a shared-source academic and commercial software package which uses density functional theory with a plane wave basis set to calculate the electronic properties of crystalline solids, surfaces, molecules, liquids and amorphous materials from first principles. CASTEP permits geometry optimisation and finite temperature molecular dynamics with implicit symmetry and geometry constraints, as well as calculation of a wide variety of derived properties of the electronic configuration. Although CASTEP was originally a serial, Fortran 77-based program, it was completely redesigned and rewritten from 1999 to 2001 using Fortran 95 and MPI for use on parallel computers by researchers at the Universities of York, Durham, St. Andrews, Cambridge and Rutherford Labs. History CASTEP was created in the late 1980s and early 1990s in the TCM Group of the Cavendish Laboratory in Cambridge. It was then an academic code written in Fortran77, and the name was originally derived from CAmbridge Serial Total Energy Package. In the mid 1990s it was commercialised by licensing it to Molecular Simulations International (the company was later purchased by Accelrys, in turn purchased by Biovia) in an arrangement through which the University of Cambridge received a share of the royalties, and much of the development remained with the original academic authors. The code was then redesigned and completely rewritten from 1999–2001 to make use of the features of modern Fortran, enable parallelism throughout the code and improve its software sustainability. The name CASTEP was adopted by the new codebase, but without the implied former meaning since the code was now parallel, and capable of computing many quantities besides the total energy. By this point annual sales exceeded £1m. Despite its commercialisation, CASTEP and its source code remained free to UK academics. In 2019 the free academic licence was extended to world-wide academic use (not just UK academia). Commercial users can pu
https://en.wikipedia.org/wiki/Dubna%2048K
The Dubna 48K (Дубна 48К) is a Soviet clone of the ZX Spectrum home computer launched in 1991. It was based on an analogue of the Zilog Z80 microprocessor. Its name comes from Dubna, a town near Moscow, where it was produced on the "TENSOR" instrument factory, and "48K" stands for 48 KBs of RAM. Overview According to the manual, this computer was intended for: studying the principles of PC operation various kinds of calculations "intellectual games" By the time this computer was released (1991), there were already much more powerful x86 CPUs and commercially available advanced operating systems, such as Unix, DOS and Windows. The Dubna 48K had only a built-in BASIC interpreter, and loaded its programs from a cassette recorder, so it couldn't run any of the modern operating systems. However, the Dubna 48K and many other Z80 clones, though outdated by that time, were introduced in high schools of the Soviet Union. Many of the games for the Z80-based machine were ported from games already available for Nintendo's 8-bit game console, marketed in Russia under the brand Dendy. The machine comes in two versions: in a metal case for the initial 1991 model, and in a plastic case for the 1992 model. Included items The Dubna 48K was shipped with the following units: Main unit ("data processing unit", as stated on its back side), with mainboard and built-in keyboard External power unit Video adapter for connecting the computer to the TV set BASIC programming manual Reference book, including complete schematic circuit Additionally, there were some optional items: Joystick 32 cm (12") colour monitor The computer could also connect to a ZX Microdrive, but such device was never included. Technical details CPU: 8-bit MME 80A at 1.875 MHz (half the speed of the original ZX Spectrum) RAM: 48 KB (16× КР565РУ5Г chips) ROM: 16 KB (2× К573РФ4А) Resolution: 256 x 192 pixels, or 24 rows of 32 characters each Number of colours: 8 colours in either normal or bright mode,
https://en.wikipedia.org/wiki/Solar%20conjunction
Solar conjunction generally occurs when a planet or other Solar System object is on the opposite side of the Sun from the Earth. From an Earth reference, the Sun will pass between the Earth and the object. Communication with any spacecraft in solar conjunction will be severely limited due to the Sun's interference on radio transmissions from the spacecraft. The term can also refer to the passage of the line of sight to an interior planet (Mercury or Venus) or comet being very close to the solar disk. If the planet passes directly in front of the Sun, a solar transit occurs. Spacecraft-related issues There is also a risk that an antenna equipped with auto-tracking will begin following the Sun's movements instead of the satellite once they are no longer inline with each other. This is because the Sun acts as a large electromagnetic noise generator which creates a signal much stronger than the satellite's tracking signal. One example of limitations caused by the solar conjunction occurred when the NASA-JPL team put the Curiosity rover on Mars' surface in autonomous operation mode for 25 days during the conjunction. In autonomous mode Curiosity suspends all movements and active science operations but retains communication-independent experiments (e.g. record atmospheric and radiation data). A more recent example occurred with the Mars rover Perseverance in October of 2021. See also Conjunction (astronomy and astrology) List of conjunctions (astronomy) Opposition (astronomy)
https://en.wikipedia.org/wiki/Hybrid%20integrated%20circuit
A hybrid integrated circuit (HIC), hybrid microcircuit, hybrid circuit or simply hybrid is a miniaturized electronic circuit constructed of individual devices, such as semiconductor devices (e.g. transistors, diodes or monolithic ICs) and passive components (e.g. resistors, inductors, transformers, and capacitors), bonded to a substrate or printed circuit board (PCB). A PCB having components on a Printed Wiring Board (PWB) is not considered a true hybrid circuit according to the definition of MIL-PRF-38534. Overview "Integrated circuit" as the term is currently used refers to a monolithic IC which differs notably from a HIC in that a HIC is fabricated by inter-connecting a number of components on a substrate whereas an IC's (monolithic) components are fabricated in a series of steps entirely on a single wafer which is then diced into chips. Some hybrid circuits may contain monolithic ICs, particularly Multi-chip module (MCM) hybrid circuits. Hybrid circuits could be encapsulated in epoxy, as shown in the photo, or in military and space applications, a lid was soldered onto the package. A hybrid circuit serves as a component on a PCB in the same way as a monolithic integrated circuit; the difference between the two types of devices is in how they are constructed and manufactured. The advantage of hybrid circuits is that components which cannot be included in a monolithic IC can be used, e.g., capacitors of large value, wound components, crystals, inductors. In military and space applications, numerous integrated circuits, transistors and diodes, in their die form, would be placed on either a ceramic or beryllium substrate. Either gold or aluminum wire would be bonded from the pads of the IC, transistor, or diode to the substrate. Thick film technology is often used as the interconnecting medium for hybrid integrated circuits. The use of screen printed thick film interconnect provides advantages of versatility over thin film although feature sizes may be larg
https://en.wikipedia.org/wiki/Property%20list
In the macOS, iOS, NeXTSTEP, and GNUstep programming frameworks, property list files are files that store serialized objects. Property list files use the filename extension .plist, and thus are often referred to as p-list files. Property list files are often used to store a user's settings. They are also used to store information about bundles and applications, a task served by the resource fork in the old Mac OS. Property lists are also used for localization strings for development. These files use the .strings or .stringsdict extensions. The former is a "reduced" old-style plist containing only one dictionary without the braces (see ), while the latter is a fully-fledged plist. Xcode also uses a .pbxproj extension for old-style plists used as project files. Representations Since the data represented by property lists is somewhat abstract, the underlying file format can be implemented many ways. Namely, NeXTSTEP used one format to represent a property list, and the subsequent GNUstep and macOS frameworks introduced differing formats. NeXTSTEP Under NeXTSTEP, property lists were designed to be human-readable and edited by hand, serialized to ASCII in a syntax somewhat like a programming language. This same format was used by OPENSTEP. Strings are represented in C literal style: ; simpler, unquoted strings are allowed as long as they consist of alphanumericals and one of . Binary data are represented as: < [hexadecimal codes in ASCII] >. Spaces and comments between paired hex-codes are ignored. Arrays are represented as: . Trailing commas are tolerated. Dictionaries are represented as: . The left-hand side must be a string, but it can be unquoted. Comments are allowed as: and . As in C, whitespace are generally insignificant to syntax. Value statements terminate by a semicolon. One limitation of the original NeXT property list format is that it could not represent an NSValue (number, boolean, etc.) object. As a result, these values would have to be
https://en.wikipedia.org/wiki/Sister%20group
In phylogenetics, a sister group or sister taxon, also called an adelphotaxon, comprises the closest relative(s) of another given unit in an evolutionary tree. Definition The expression is most easily illustrated by a cladogram: Taxon A and taxon B are sister groups to each other. Taxa A and B, together with any other extant or extinct descendants of their most recent common ancestor (MRCA), form a monophyletic group, the clade AB. Clade AB and taxon C are also sister groups. Taxa A, B, and C, together with all other descendants of their MRCA form the clade ABC. The whole clade ABC is itself a subtree of a larger tree which offers yet more sister group relationships, both among the leaves and among larger, more deeply rooted clades. The tree structure shown connects through its root to the rest of the universal tree of life. In cladistic standards, taxa A, B, and C may represent specimens, species, genera, or any other taxonomic units. If A and B are at the same taxonomic level, terminology such as sister species or sister genera can be used. Example The term sister group is used in phylogenetic analysis, however, only groups identified in the analysis are labeled as "sister groups". An example is birds, whose commonly cited living sister group is the crocodiles, but that is true only when discussing extant organisms; when other, extinct groups are considered, the relationship between birds and crocodiles appears distant. Although the bird family tree is rooted in the dinosaurs, there were a number of other, earlier groups, such as the pterosaurs, that branched off of the line leading to the dinosaurs after the last common ancestor of birds and crocodiles. The term sister group must thus be seen as a relative term, with the caveat that the sister group is only the closest relative among the groups/species/specimens that are included in the analysis. Notes
https://en.wikipedia.org/wiki/Longest%20uncrossed%20knight%27s%20path
The longest uncrossed (or nonintersecting) knight's path is a mathematical problem involving a knight on the standard 8×8 chessboard or, more generally, on a square n×n board. The problem is to find the longest path the knight can take on the given board, such that the path does not intersect itself. A further distinction can be made between a closed path, which ends on the same field as where it begins, and an open path, which ends on a different field from where it begins. Known solutions The longest open paths on an n×n board are known only for n ≤ 9. Their lengths for n = 1, 2, …, 9 are: 0, 0, 2, 5, 10, 17, 24, 35, 47 The longest closed paths are known only for n ≤ 10. Their lengths for n = 1, 2, …, 10 are: 0, 0, 0, 4, 8, 12, 24, 32, 42, 54 Generalizations The problem can be further generalized to rectangular n×m boards, or even to boards in the shape of any polyomino. The problem for n×m boards, where n doesn't exceed 8 and m might be very large was given at 2018 ICPC World Finals. The solution used dynamic programming and uses the fact that the solution should exhibit a cyclic behavior. Other standard chess pieces than the knight are less interesting, but fairy chess pieces like the camel ((3,1)-leaper), giraffe ((4,1)-leaper) and zebra ((3,2)-leaper) lead to problems of comparable complexity. See also A knight's tour is a self-intersecting knight's path visiting all fields of the board. TwixT, a board game based on uncrossed knight's paths.
https://en.wikipedia.org/wiki/Matrix%20isolation
Matrix isolation is an experimental technique used in chemistry and physics. It generally involves a material being trapped within an unreactive matrix. A host matrix is a continuous solid phase in which guest particles (atoms, molecules, ions, etc.) are embedded. The guest is said to be isolated within the host matrix. Initially the term matrix-isolation was used to describe the placing of a chemical species in any unreactive material, often polymers or resins, but more recently has referred specifically to gases in low-temperature solids. A typical matrix isolation experiment involves a guest sample being diluted in the gas phase with the host material, usually a noble gas or nitrogen. This mixture is then deposited on a window that is cooled to below the melting point of the host gas. The sample may then be studied using various spectroscopic procedures. Experimental setup The transparent window, on to which the sample is deposited, is usually cooled using a compressed helium or similar refrigerant. Experiments must be performed under a high vacuum to prevent contaminants from unwanted gases freezing to the cold window. Lower temperatures are preferred, due to the improved rigidity and "glassiness" of the matrix material. Noble gases such as argon are used not just because of their unreactivity but also because of their broad optical transparency in the solid state. Mono-atomic gases have relatively simple face-centered cubic (fcc) crystal structure, which can make interpretations of the site occupancy and crystal-field splitting of the guest easier. In some cases a reactive material, for example, methane, hydrogen or ammonia, may be used as the host material so that the reaction of the host with the guest species may be studied. Using the matrix isolation technique, short-lived, highly-reactive species such as radical ions and reaction intermediates may be observed and identified by spectroscopic means. For example, the solid noble gas krypton can be used to
https://en.wikipedia.org/wiki/Stuck-at%20fault
A stuck-at fault is a particular fault model used by fault simulators and automatic test pattern generation (ATPG) tools to mimic a manufacturing defect within an integrated circuit. Individual signals and pins are assumed to be stuck at Logical '1', '0' and 'X'. For example, an input is tied to a logical 1 state during test generation to assure that a manufacturing defect with that type of behavior can be found with a specific test pattern. Likewise the input could be tied to a logical 0 to model the behavior of a defective circuit that cannot switch its output pin. Not all faults can be analyzed using the stuck-at fault model. Compensation for static hazards, namely branching signals, can render a circuit untestable using this model. Also, redundant circuits cannot be tested using this model, since by design there is no change in any output as a result of a single fault. Single stuck at line Single stuck line is a fault model used in digital circuits. It is used for post manufacturing testing, not design testing. The model assumes one line or node in the digital circuit is stuck at logic high or logic low. When a line is stuck it is called a fault. Digital circuits can be divided into: Gate level or combinational circuits which contain no storage (latches and/or flip flops) but only gates like NAND, OR, XOR, etc. Sequential circuits which contain storage. This fault model applies to gate level circuits, or a block of a sequential circuit which can be separated from the storage elements. Ideally a gate-level circuit would be completely tested by applying all possible inputs and checking that they gave the right outputs, but this is completely impractical: an adder to add two 32-bit numbers would require 264 = 1.8*1019 tests, taking 58 years at 0.1 ns/test. The stuck at fault model assumes that only one input on one gate will be faulty at a time, assuming that if more are faulty, a test that can detect any single fault, should easily find multiple faults.
https://en.wikipedia.org/wiki/Dialed%20Number%20Identification%20Service
Dialed Number Identification Service (DNIS) is a service offered by telecommunications companies to corporate clients which identifies the originally dialed telephone number of an inbound call. The client may use this information for call routing to internal destinations or activation of special call handling. For DNIS service, the telephone company sends a sequence of typically four to ten digits during call setup. Direct inward dial (DID) service also provides DNIS. For example, a company may have a different toll-free telephone number for each product line it sells, or for multilingual customer support. If a call center is handling calls for multiple product lines, the corporate telephone system that receives the call analyzes the DNIS signaling and may play an appropriate recorded greeting. For interactive voice response (IVR) systems, DNIS is used as routing information for dispatching purposes, to determine which script or service should be activated based on the number that was dialed to reach the IVR platform. In the United States, DNIS is commonly provided for 800- and 900-services. See also Automatic number identification
https://en.wikipedia.org/wiki/Aristotle%27s%20wheel%20paradox
Aristotle's wheel paradox is a paradox or problem appearing in the pseudo-Aristotelian Greek work Mechanica It states as follows: A wheel is depicted in two-dimensional space as two circles. Its larger, outer circle is tangential to a horizontal surface (e.g. a road that it rolls on), while the smaller, inner one has the same center and is rigidly affixed to the larger. (The smaller circle could be the bead of a tire, the rim it is mounted upon, or the axle.) Assuming the larger circle rolls without slipping (or skidding) for one full revolution, the distances moved by both circles' circumferences are the same. The distance travelled by the larger circle is equal to its circumference, but for the smaller it is greater than its circumference, thereby creating a paradox. The paradox is not limited to wheels: other things depicted in two dimensions display the same behavior such as a roll of tape, or a typical round bottle or jar rolled on its side (the smaller circle would be the mouth or neck of the jar or bottle). In an alternative version of the problem, the smaller circle, rather than the larger one, is in contact with the horizontal surface. Examples include a typical train wheel, which has a flange, or a barbell straddling a bench. American educator and philosopher Israel Drabkin called these Case II versions of the paradox, and a similar, but unidentical, analysis applies. History of the paradox In antiquity In antiquity, the wheel problem was described in the Greek work Mechanica, traditionally attributed to Aristotle, but widely believed to have been written by a later member of his school. (Thomas Winter has made the alternative proposal that it was written by Archytas.) It also appears in the Mechanica of Hero of Alexandria. In the Aristotelian version it appears as "Problem 24", where the description of the wheel is given as follows: For let there be a larger circle ΔZΓ a smaller EHB, and A at the centre of both; let ZI be the line which the greater
https://en.wikipedia.org/wiki/Variable%20Energy%20Cyclotron%20Centre
The Variable Energy Cyclotron Centre (VECC) is a research and development unit of the Department of Atomic Energy. The VECC is located in Kolkata, India and performs research in basic and applied nuclear sciences and development of the latest nuclear particle accelerators. It has a collaboration with the European Organization for Nuclear Research. The Centre houses a 224 cm cyclotron—the first of its kind in India—which has been operational since 16 June 1977. It provides proton, deuteron, alpha particle and heavy ion beams of various energies to other institutions. The Centre consists of major facilities such as K130 Cyclotron, K500 Superconducting Cyclotron, Cyclone-30 Medical Cyclotron, Radioactive Ion Beam (RIB) Facility, Computing Centre, Regional Radiation Medicine Centre and a new Campus for the proposed ANURIB project at New Town, Rajarhat. The ANURIB (Advanced National facility for Unstable & Rare-Isotope Beams) is a planned facility, to be constructed in collaboration with the Canada-based research institute TRIUMF. ANURIB is going to conduct experiments of unstable & rare isotope beams.
https://en.wikipedia.org/wiki/Erythranthe%20guttata
Erythranthe guttata, with the common names seep monkeyflower and common yellow monkeyflower, is a yellow bee-pollinated annual or perennial plant. It was formerly known as Mimulus guttatus. Erythranthe guttata is a model organism for biological studies, and in that context is still referred to as Mimulus guttatus. There may be as many as 1000 scientific papers focused on this species. The genome is (as of 2012) being studied in depth. For combined research of evolution, genetics, and ecology, particularly plant-insect interactions, the yellow monkeyflower has become a model system. With the help of physically resistant protections called trichomes, which have been thoroughly examined, the yellow monkeyflower defends itself against herbivores. Description A highly variable plant, taking many forms, E. guttata is a species complex in that there is room to treat some of its forms as different species by some definitions. The plant ranges from tall with disproportionately large, 2 to 4 cm long, tubular flowers. The perennial form spreads with stolons or rhizomes. The stem may be erect or recumbent. In the latter form, roots may develop at leaf nodes. Sometimes dwarfed, it may be hairless or have some hairs. Leaves are opposite, round to oval, usually coarsely and irregularly toothed or lobed. The bright yellow flowers are born on a raceme, most often with five or more flowers. The calyx has five lobes that are much shorter than the flower. Each flower has bilateral symmetry and has two lips. The upper lip usually has two lobes; the lower, three. The lower lip may have one large to many small red to reddish brown spots (hence the name guttata, which is Latin for 'spotted'). The opening to the flower is hairy. Erythranthe guttata is pollinated by bees, such as Bombus species. Inbreeding reduces flower quantity and size and pollen quality and quantity. E. guttata also displays a high degree of self-pollination. Erythranthe nasuta (Mimulus nasutus) evolved from E.
https://en.wikipedia.org/wiki/Reserve%20wine
Reserve wine is wine of a higher quality than usual, a wine that has been aged before sale, or both. Traditionally, winemakers would reserve some of their best wine rather than sell it immediately, coining the term. In some countries the use of the term "reserve", "reserva" or "riserva" is regulated, but in many places it is not. According to Italian wine laws, riserva indicates additional aging. Sometimes, reserve wine originates from the best vineyards, or the best barrels. Reserve wines may be made in a style suited to longer aging periods. In regions where the use is not regulated, the presence of the term "reserve" on a wine label may be a marketing strategy, without specific criteria. In Kendall-Jackson Chardonnay, every bottle produced is "Vintner's Reserve", and to indicate a traditional reserve wine, Kendall-Jackson uses the term "Grand Reserve". Like the term "old vines", "reserve" traditionally indicates a wine that is special, or at least different in flavor or aging potential. The presence of a non-reserve bottling with a producer that also sells reserve wine makes it more likely that "reserve" is used in its traditional sense. Partly because of the often vague meaning of "reserve", many wineries produce named cuvées instead. Typically these are reserve wines in the traditional meaning of the word. Iberia In Spain, reserva is a regulated term controlled by law, at least ensuring that reserve wines get some additional aging. In practice it is very difficult to regulate quality, so the term primarily deals with ageing and alcoholic strength. In Spanish wines, the requirements varies between regions, but typically, when used on a label "Reserva" means that the wine was aged for at least three years in the cask and bottle, at least one of which must have been in the cask. Those that have been aged for five years (two in cask, three in bottle) or more are labelled . Gran Reservas are intended to be made only in exceptional vintages, but this is up to th
https://en.wikipedia.org/wiki/International%20School%20for%20Advanced%20Studies
The International School for Advanced Studies (Italian: Scuola Internazionale Superiore di Studi Avanzati; SISSA) is an international, state-supported, post-graduate-education and research institute in Trieste, Italy. SISSA is active in the fields of mathematics, physics and neuroscience, offering both undergraduate and post-graduate courses. Each year, about 70 PhD students are admitted to SISSA based on their scientific qualifications. SISSA also runs master's programs in the same areas, in collaboration with both Italian and other European universities. History SISSA was founded in 1978, as a part of the reconstruction following the Friuli earthquake of 1976. Although the city of Trieste itself did not suffer any damage, physicist Paolo Budinich asked and obtained from the Italian government to include in the interventions the institution of a new, post-graduate teaching and research institute, modeled on the Scuola Normale Superiore di Pisa. The school became operative with a PhD course in theoretical physics, and Budinich himself was appointed as general director. In 1986, Budinich left his position to Daniele Amati, who at the time was at the head of the theoretical division at CERN. Under his leadership, SISSA expanded its teaching and research activity towards the field of neuroscience, and instituted a new interdisciplinary laboratory aiming at connecting humanities and scientific studies. From 2001 to 2004, the director was the Italian geneticist Edoardo Boncinelli, who fostered the development of the existing research areas. From 2004 to 2010, the director was the Italian physicist Stefano Fantoni. His period as director has been characterized by the design and construction of the new SISSA location. Other directors were appointed in the following years, which saw the strengthening of SISSA collaboration with other Italian and European universities in offering master's degree programs in the three areas of the School (mathematics, physics and neurosci
https://en.wikipedia.org/wiki/King%20Pharmaceuticals
King Pharmaceuticals, is a pharmaceutical company, a wholly owned subsidiary of Pfizer based in Bristol, Tennessee. Before being acquired by Pfizer, it was the world's 39th largest pharmaceutical company. On October 12, 2010, King was acquired by Pfizer for $14.25 per share. King produced a wide range of pharmaceuticals, including Altace for heart attack prevention, Levoxyl for hypothyroidism, Sonata, a sleeping aid, and Skelaxin, a muscle relaxant. King Pharmaceuticals operated manufacturing facilities in Bristol, Tennessee; Rochester, Michigan; St. Louis, Missouri; St. Petersburg, Florida; and Middleton, Wisconsin. They employed approximately 2,700 people including a sales force of over 1,000 individuals. King Pharmaceuticals, Inc. was incorporated in the State of Tennessee in 1993. According to the King Pharmaceutcals, Inc. Form 10-K for the year ended December 31, 2007 filed with the U.S. Securities and Exchange Commission, the wholly owned subsidiaries of King Pharmaceuticals, Inc. are Monarch Pharmaceuticals, Inc.; King Pharmaceuticals Research and Development, Inc.; Meridian Medical Technologies, Inc.; Parkedale Pharmaceuticals, Inc.; King Pharmaceuticals Canada Inc.; and Monarch Pharmaceuticals Ireland Limited. Company history King Pharmaceuticals was founded in 1993 John M. Gregory, Randal J. Kirk, Joseph "Joe" R. Gregory, Jefferson "Jeff" J. Gregory, and James E. Gregory. In January 1994, King acquired a former King College campus plant in Bristol, Tennessee. The facility was purchased for $1.18 million from RSR Pharmaceutical, who had been using it after Beecham merged with SmithKline. King initially manufactured drugs for other pharmaceutical companies, but soon established a strategy of acquiring branded prescription drugs, which have a much higher gross margin than contract manufactured drugs. In February 1998, King acquired 15 branded pharmaceuticals, a sterile products manufacturing facility located in Rochester, Michigan that it called the "
https://en.wikipedia.org/wiki/Melphalan
Melphalan, sold under the brand name Alkeran among others, is a chemotherapy medication used to treat multiple myeloma; malignant lymphoma; lymphoblastic and myeloblastic leukemia; childhood neuroblastoma; ovarian cancer; mammary adenocarcinoma; and uveal melanoma. It is taken by mouth or by injection into a vein. Common side effects include nausea and bone marrow suppression. Other severe side effects may include anaphylaxis and the development of other cancers. Use during pregnancy may result in harm to the fetus. Melphalan belongs to the class of nitrogen mustard alkylating agents. It works by interfering with the creation of DNA and RNA. Melphalan was approved for medical use in the United States in 1964. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. Medical uses In the European Union, melphalan is indicated for the treatment of multiple myeloma; malignant lymphoma (Hodgkin, non-Hodgkin lymphoma); acute lymphoblastic and myeloblastic leukemia; childhood neuroblastoma; ovarian cancer; and mammary adenocarcinoma. In the United States, melphalan is used as a high-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in people with multiple myeloma. In the European Union, it is indicated, in combination with other cytotoxic medicinal products, as reduced intensity conditioning treatment prior to allogeneic haematopoietic stem cell transplantation in malignant haematological diseases in adults. In August 2023, the US Food and Drug Administration approved melphalan (Hepzato) as a liver-directed treatment for adults with uveal melanoma with unresectable hepatic metastases affecting less than 50% of the liver and no extrahepatic disease, or extrahepatic disease limited to the bone, lymph nodes, subcutaneous tissues, or lung that is amenable to resection or radiation. Side effects Common side effects include: Nausea Bone marrow suppression, including Decreased
https://en.wikipedia.org/wiki/Captan
Captan is a general use pesticide (GUP) that belongs to the phthalimide class of fungicides. It is a white solid, although commercial samples appear yellow or brownish. Applications Although it can be applied on its own, Captan is often added as a component of other pesticide mixtures. It is used to control diseases on a number of fruits and vegetables as well as ornamental plants. It also improves the outward appearance of many fruits, making them brighter and healthier-looking. Captan is utilized by both home and agricultural growers and is often applied during apple production. It is also active against certain oomycetes, such as Pythium, making it useful for controlling damping off. Biodegradation The compound biodegrades with half life of less than 1 day in soil. Potential health effects Captan was previously cited as Group B2, a probable human carcinogen by the US Environmental Protection Agency (EPA), but was reclassified in 2004. Since the mode of action has been established as a proliferative response (in mice only) after intestinal villi are disrupted, captan has been deemed not likely to cause tumors at doses that do not irritate the intestine. The EPA now states, "The new cancer classification considers captan to be a potential carcinogen at prolonged high doses that cause cytotoxicity and regenerative cell hyperplasia. These high doses of captan are many orders of magnitude above those likely to be consumed in the diet, or encountered by individuals in occupational or residential settings. Therefore, captan is not likely to be a human carcinogen nor pose cancer risks of concern when used in accordance with approved product labels. A similar reclassification has been made for folpet, a structurally related fungicide, which shares a common mechanism of toxicity. A key finding for captan (and folpet) is these fungicides are not mutagenic in the animal (in vivo). Production It is the product of the reaction trichloromethylsulfenyl chloride with sodium s
https://en.wikipedia.org/wiki/Focal%20adhesion
In cell biology, focal adhesions (also cell–matrix adhesions or FAs) are large macromolecular assemblies through which mechanical force and regulatory signals are transmitted between the extracellular matrix (ECM) and an interacting cell. More precisely, focal adhesions are the sub-cellular structures that mediate the regulatory effects (i.e., signaling events) of a cell in response to ECM adhesion. Focal adhesions serve as the mechanical linkages to the ECM, and as a biochemical signaling hub to concentrate and direct numerous signaling proteins at sites of integrin binding and clustering. Structure and function Focal adhesions are integrin-containing, multi-protein structures that form mechanical links between intracellular actin bundles and the extracellular substrate in many cell types. Focal adhesions are large, dynamic protein complexes through which the cytoskeleton of a cell connects to the ECM. They are limited to clearly defined ranges of the cell, at which the plasma membrane closes to within 15 nm of the ECM substrate. Focal adhesions are in a state of constant flux: proteins associate and disassociate with it continually as signals are transmitted to other parts of the cell, relating to anything from cell motility to cell cycle. Focal adhesions can contain over 100 different proteins, which suggests a considerable functional diversity. More than anchoring the cell, they function as signal carriers (sensors), which inform the cell about the condition of the ECM and thus affect their behavior. In sessile cells, focal adhesions are quite stable under normal conditions, while in moving cells their stability is diminished: this is because in motile cells, focal adhesions are being constantly assembled and disassembled as the cell establishes new contacts at the leading edge, and breaks old contacts at the trailing edge of the cell. One example of their important role is in the immune system, in which white blood cells migrate along the connective endotheli
https://en.wikipedia.org/wiki/Medical%20geology
Medical geology is an interdisciplinary scientific field studying the relationship between natural geological factors and their effects on human and animal health. The Commission on Geological Sciences for Environmental Planning defines medical geology as "the science dealing with the influence of ordinary environmental factors on the geographical distribution of health problems in man and animals." In its broadest sense, medical geology studies exposure to or deficiency of trace elements and minerals; inhalation of ambient and anthropogenic mineral dusts and volcanic emissions; transportation, modification and concentration of organic compounds; and exposure to radionuclides, microbes and pathogens. History Many have deemed medical geology as a new field, when in actuality it is re-emerging. Hippocrates and Aristotle first recognized the relationship between human diseases and the earth's elements. This field ultimately depends on a number of different fields coming and working together to solve some of the earth's mysteries. The scientific term for this field is hydrobiogeochemoepidemiopathoecology; however, it is more commonly known as medical geology. It was established in 1990 by the International Union of Geological Sciences. Paracelsus, the "father of pharmacology" (1493–1541), stated that "all substances are poisons, there is none which is not a poison. The right dosage differentiates a poison and a remedy." This passage sums up the idea of medical geology. The goal of this field is to find the right balance and intake of elements/minerals in order to improve and maintain health. Examples of research in medical geology include: Studies on the impact of contaminant mobility as a result of extreme weather events such as flooding. Lead and other heavy metal exposure resulting from dust and other particulates Asbestos exposure such as amphibole asbestos dusts in Libby, Montana Fungal infection resulting from airborne dust, such as Valley Fever or coccidio
https://en.wikipedia.org/wiki/Podosome
Podosomes are conical, actin-rich structures found on the outer surface of the plasma membrane of animal cells. Their size ranges from approximately 0.5 µm to 2.0 µm in diameter. While usually situated on the periphery of the cellular membrane, these unique structures display a polarized pattern of distribution in migrating cells, situating at the front border between the lamellipodium and lamellum. Their primary purpose is connected to cellular motility and invasion; therefore, they serve as both sites of attachment and degradation along the extracellular matrix. Many different specialized cells exhibit these dynamic structures such as invasive cancer cells, osteoclasts, vascular smooth muscle cells, endothelial cells, and certain immune cells like macrophages and dendritic cells. Characteristics A podosome consists of a core rich in actin surrounded by adhesion and scaffolding proteins. The actin filaments within these structures are highly regulated by many actin nucleators, polymerization activators, actin binding and crosslinking proteins, kinases, small GTPases, and scaffold proteins; therefore, total actin turnover occurs within seconds. To distinguish podosomes from others types of cellular adhesions, the protein Tks5 and WASP (Wiskott–Aldrich syndrome protein) are used as markers alongside actin, cortactin and the Arp2/3 complex to localize and isolate these protrusions because Tks5 and WASP are unique to the podosome when compared with other actin-based cellular structures. In their outward structure, the podosomes demonstrate two distinct features: an actin core and a ring complex. Within the core, coordinators of actin nucleation are found. Specifically, the Arp2/3 complex and WASP when close to the plasma membrane or cortactin when further away comprise this group of proteins. Emanating radially from the dense core of actin are actin filaments reaching to the plasma membrane and between neighboring podosomes. In the ring complex, integrins and inte
https://en.wikipedia.org/wiki/Molecular%20electronic%20transition
In theoretical chemistry, molecular electronic transitions take place when electrons in a molecule are excited from one energy level to a higher energy level. The energy change associated with this transition provides information on the structure of the molecule and determines many of its properties, such as colour. The relationship between the energy involved in the electronic transition and the frequency of radiation is given by Planck's relation. Organic molecules and other molecules The electronic transitions in organic compounds and some other compounds can be determined by ultraviolet–visible spectroscopy, provided that transitions in the ultraviolet (UV) or visible range of the electromagnetic spectrum exist for the compound. Electrons occupying a HOMO (highest-occupied molecular orbital) of a sigma bond (σ) can get excited to the LUMO (lowest-unoccupied molecular orbital) of that bond. This process is denoted as a transition. Likewise, promotion of an electron from a pi-bonding orbital (π) to an antibonding pi orbital (π*) is denoted as a transition. Auxochromes with free electron pairs (denoted as "n") have their own transitions, as do aromatic pi bond transitions. Sections of molecules which can undergo such detectable electron transitions can be referred to as chromophores, since such transitions absorb electromagnetic radiation (light), which may be hypothetically perceived as color somewhere in the electromagnetic spectrum. The following molecular electronic transitions exist: In addition to these assignments, electronic transitions also have so-called bands associated with them. The following bands are defined (by A. Burawoy in 1930): The R-band (); The K-band (); The B-band (from benzoic); The E-band (from ethylenic). For example, the absorption spectrum for ethane shows a transition at 135 nm and that of water a transition at 167 nm with an extinction coefficient of 7,000. Benzene has three transitions; two E-bands at 180 and 200 nm and one
https://en.wikipedia.org/wiki/Grad%E2%80%93Shafranov%20equation
The Grad–Shafranov equation (H. Grad and H. Rubin (1958); Vitalii Dmitrievich Shafranov (1966)) is the equilibrium equation in ideal magnetohydrodynamics (MHD) for a two dimensional plasma, for example the axisymmetric toroidal plasma in a tokamak. This equation takes the same form as the Hicks equation from fluid dynamics. This equation is a two-dimensional, nonlinear, elliptic partial differential equation obtained from the reduction of the ideal MHD equations to two dimensions, often for the case of toroidal axisymmetry (the case relevant in a tokamak). Taking as the cylindrical coordinates, the flux function is governed by the equation,where is the magnetic permeability, is the pressure, and the magnetic field and current are, respectively, given by The nature of the equilibrium, whether it be a tokamak, reversed field pinch, etc. is largely determined by the choices of the two functions and as well as the boundary conditions. Derivation (in Cartesian coordinates) In the following, it is assumed that the system is 2-dimensional with as the invariant axis, i.e. produces 0 for any quantity. Then the magnetic field can be written in cartesian coordinates as or more compactly, where is the vector potential for the in-plane (x and y components) magnetic field. Note that based on this form for B we can see that A is constant along any given magnetic field line, since is everywhere perpendicular to B. (Also note that -A is the flux function mentioned above.) Two dimensional, stationary, magnetic structures are described by the balance of pressure forces and magnetic forces, i.e.: where p is the plasma pressure and j is the electric current. It is known that p is a constant along any field line, (again since is everywhere perpendicular to B). Additionally, the two-dimensional assumption () means that the z- component of the left hand side must be zero, so the z-component of the magnetic force on the right hand side must also be zero. This means that
https://en.wikipedia.org/wiki/Fungal%20pneumonia
Fungal pneumonia is an infection of the lungs by fungi. It can be caused by either endemic or opportunistic fungi or a combination of both. Case mortality in fungal pneumonias can be as high as 90% in immunocompromised patients, though immunocompetent patients generally respond well to anti-fungal therapy. Signs and symptoms Fungal pneumonia can present similarly to that of the common flu or other common illnesses. Symptoms often include fever, cough, headaches, rashes, muscle aches, and/or joint pain. This can lead to treatment being delayed or unsought altogether. In a very small portion of people, fungal pneumonia can lead to chronic pneumonia, fungemia (presence of fungi in the blood), meningitis (infection of the meninges of the brain or spine), or even death. However, this is extremely rare and the vast majority of cases go untreated, unreported, or are asymptomatic (e.g. the infected person is not aware they are or were infected). Causes Specific instances of fungal infections that can manifest with pulmonary involvement include: Coccidioidomycosis, which begins with an often self-limited respiratory infection (also called "Valley fever" or "San Joaquin fever") Pneumocystis pneumonia, which typically occurs in immunocompromised people, especially AIDS Sporotrichosis — primarily a skin disease, but can involve the lungs as well Cryptococcus species can sometimes invade the lungs Aspergillosis, resulting in invasive pulmonary aspergillosis rarely, candidiasis has pulmonary manifestations in immunocompromised patients. Histoplasmosis or Spelunker's lung Pathophysiology Fungi typically enter the lung with inhalation of their spores, though they can reach the lung through the bloodstream if other parts of the body are infected. Also, fungal pneumonia can be caused by reactivation of a latent infection. Once inside the alveoli, fungi travel into the spaces between the cells and also between adjacent alveoli through connecting pores. This invasion trigge
https://en.wikipedia.org/wiki/Hartnup%20disease
Hartnup disease (also known as "pellagra-like dermatosis" and "Hartnup disorder") is an autosomal recessive metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin). Niacin is a precursor to nicotinamide, a necessary component of NAD+. The causative gene, SLC6A19, is located on chromosome 5. It is named after the British family, Hartnup, who had this disease. Signs and symptoms Hartnup disease manifests during infancy with variable clinical presentation: failure to thrive, photosensitivity, intermittent ataxia, nystagmus, and tremor. Nicotinamide is necessary for neutral amino acid transporter production in the proximal renal tubules found in the kidney, and intestinal mucosal cells found in the small intestine. Therefore, a symptom stemming from this disorder results in increased amounts of amino acids in the urine. Pellagra, a similar condition, is also caused by low nicotinamide; this disorder results in dermatitis, diarrhea, and dementia. Hartnup disease is a disorder of amino acid transport in the intestine and kidneys; otherwise, the intestine and kidneys function normally, and the effects of the disease occur mainly in the brain and skin. Symptoms may begin in infancy or early childhood, but sometimes they begin as late as early adulthood. Symptoms may be triggered by sunlight, fever, drugs, or emotional or physical stress. A period of poor nutrition nearly always precedes an attack. The attacks usually become progressively less frequent with age. Most symptoms occur sporadically and are caused by a deficiency of niacinamide. A rash develops on parts of the body exposed to the sun. Mental retardation, short stature, headaches, unsteady gait, and collapsing or fainting are common. Psychiatric problems (such as anxiety, rapid mood changes, delusions, and hallucinations) may also result. Causes Hartnup disease is inherited as an autosomal recessi
https://en.wikipedia.org/wiki/Variable%20envelope%20return%20path
Variable envelope return path (VERP) is a technique used by some electronic mailing list software to enable automatic detection and removal of undeliverable e-mail addresses. It works by using a different return path (also called "envelope sender") for each recipient of a message. Motivation Any long-lived mailing list eventually contains addresses that can't be reached. Addresses that were once valid can become unusable because the person receiving the mail switched to a different provider. In another scenario, the address may still exist but be abandoned, with unread mail accumulating until there is not enough room left to accept any more. When a message is sent to a mailing list, the mailing list software re-sends it to all of the addresses on the list. The presence of invalid addresses in the list results in bounce messages being sent to the owner of the list. If the mailing list is small, the owner can read the bounce messages and manually remove the invalid addresses from the list. With a larger mailing list, this is a tedious, unpleasant job, so it is desirable to automate the process. However, most bounce messages have historically been designed to be read by human users, not automatically handled by software. They all convey the same basic idea ("the message from X to Y could not be delivered because of reason Z") but with so many variations that it would be nearly impossible to write a program to reliably interpret the meaning of every bounce message. RFC 1894 (obsoleted by RFC 3464) defines a standard format to fix this problem, but support for the standard is far from universal. However, there are several common formats (e.g., RFC 3464, qmail's qsbmf, and Microsoft's DSN format for Exchange) that cover large proportion of bounces. Microsoft Exchange can sometimes bounce a message without providing any indication of the address to which the original message was sent. When Exchange knows the intended recipient, but is not willing to accept email for t
https://en.wikipedia.org/wiki/Soil%20physics
Soil physics is the study of soil's physical properties and processes. It is applied to management and prediction under natural and managed ecosystems. Soil physics deals with the dynamics of physical soil components and their phases as solids, liquids, and gases. It draws on the principles of physics, physical chemistry, engineering, and meteorology. Soil physics applies these principles to address practical problems of agriculture, ecology, and engineering. Prominent soil physicists Edgar Buckingham (1867–1940) The theory of gas diffusion in soil and vadose zone water flow in soil. Willard Gardner (1883-1964) First to use porous cups and manometers for capillary potential measurements and accurately predicted the moisture distribution above a water table. Lorenzo A. Richards (1904–1993) General transport of water in unsaturated soil, measurement of soil water potential using tensiometer. John R. Philip (1927–1999) Analytical solution to general soil water transport, Environmental Mechanics. See also Agrophysics Bulk density Capacitance probe Frequency domain sensor Geotechnical engineering Irrigation Irrigation scheduling Neutron probe Soil porosity Soil thermal properties Time domain reflectometer Water content Notes Horton, Horn, Bachmann & Peth eds. 2016: Essential Soil Physics Schweizerbart, Encyclopedia of Soil Science, edts. Ward Chesworth, 2008, Uniw. of Guelph Canada, Publ. Springer, External links SSSA Soil Physics Division Soil science
https://en.wikipedia.org/wiki/Supernova%20nucleosynthesis
Supernova nucleosynthesis is the nucleosynthesis of chemical elements in supernova explosions. In sufficiently massive stars, the nucleosynthesis by fusion of lighter elements into heavier ones occurs during sequential hydrostatic burning processes called helium burning, carbon burning, oxygen burning, and silicon burning, in which the byproducts of one nuclear fuel become, after compressional heating, the fuel for the subsequent burning stage. In this context, the word "burning" refers to nuclear fusion and not a chemical reaction. During hydrostatic burning these fuels synthesize overwhelmingly the alpha nuclides (), nuclei composed of integer numbers of helium-4 nuclei. A rapid final explosive burning is caused by the sudden temperature spike owing to passage of the radially moving shock wave that was launched by the gravitational collapse of the core. W. D. Arnett and his Rice University colleagues demonstrated that the final shock burning would synthesize the non-alpha-nucleus isotopes more effectively than hydrostatic burning was able to do, suggesting that the expected shock-wave nucleosynthesis is an essential component of supernova nucleosynthesis. Together, shock-wave nucleosynthesis and hydrostatic-burning processes create most of the isotopes of the elements carbon (), oxygen (), and elements with (from neon to nickel). As a result of the ejection of the newly synthesized isotopes of the chemical elements by supernova explosions, their abundances steadily increased within interstellar gas. That increase became evident to astronomers from the initial abundances in newly born stars exceeding those in earlier-born stars. Elements heavier than nickel are comparatively rare owing to the decline with atomic weight of their nuclear binding energies per nucleon, but they too are created in part within supernovae. Of greatest interest historically has been their synthesis by rapid capture of neutrons during the r-process, reflecting the common belief that sup
https://en.wikipedia.org/wiki/Ivy%20Valentine
, commonly called , is a character in the Soulcalibur series of video games. Created by Namco's Project Soul division, she first appeared in the original Soulcalibur and its subsequent sequels, later appearing in various merchandise related to the series. She was voiced in Japanese by Yumi Tōma between Soulcalibur and Soulcalibur III, Kanako Tōjō between Soulcalibur Legends and Soulcalibur: Broken Destiny, and Miyuki Sawashiro in Soulcalibur V, and Soulcalibur VI; in English, she was voiced by Renee Hewitt in Soulcalibur II and Lani Minella for the remainder of the series. In the game, she is the illegitimate daughter of undead pirate Cervantes de Leon who was raised by a noble family until her father became obsessed with the cursed sword, Soul Edge, leading to his death and later her mother's. Desiring to destroy the sword, she creates a segmented, animated blade-whip, only to become Soul Edge's pawn and learn that it intends to use her as its next host. After an attack by Cervantes results in the loss of her soul, Ivy uses a temporary artificial one to keep herself alive, and continues after the blade. Ivy is considered one of the most prominent characters in the series as well as one of its mainstays, having appeared in every installment since Soulcalibur. She is often referred to as the series' poster girl. Since her introduction, Ivy has been regarded as an attractive and strong character by critics, and has been noted for her sex appeal. Critical reception varies, with some saying the character's oversexualization is unnecessary, while others have argued that her sexuality is an essential aspect of her character design and has allowed for her to be more recognizable. Conception and creation As a character introduced in Soulcalibur, Ivy's signature weapon, a "snake sword" designed to be unique amongst the other weapons in the game, was selected before other elements of the character. Her design and concept were then built to revolve around it by designers Ay
https://en.wikipedia.org/wiki/B-Method
The B method is a method of software development based on B, a tool-supported formal method based on an abstract machine notation, used in the development of computer software. Overview B was originally developed in the 1980s by Jean-Raymond Abrial in France and the UK. B is related to the Z notation (also originated by Abrial) and supports development of programming language code from specifications. B has been used in major safety-critical system applications in Europe (such as the automatic Paris Métro lines 14 and 1 and the Ariane 5 rocket). It has robust, commercially available tool support for specification, design, proof and code generation. Compared to Z, B is slightly more low-level and more focused on refinement to code rather than just formal specification — hence it is easier to correctly implement a specification written in B than one in Z. In particular, there is good tool support for this. The same language is used in specification, design and programming. Mechanisms include encapsulation and data locality. Event-B Subsequently, another formal method called Event-B has been developed based on the B-Method, support by the Rodin Platform. Event-B is a formal method aimed at system-level modelling and analysis. Features of Event-B are the use of set theory for modelling, the use of refinement to represent systems at different levels of abstraction, and the use of mathematical proof for verifying consistency between these refinement levels. The main components The B notation depends on set theory and first order logic in order to specify different versions of software that covers the complete cycle of project development. Abstract machine In the first and the most abstract version, which is called Abstract Machine, the designer should specify the goal of the design. Refinement Then, during a refinement step, they may pad the specification in order to clarify the goal or to turn the abstract machine more concrete by adding details about data structu
https://en.wikipedia.org/wiki/Gingerol
Gingerol ([6]-gingerol) is a phenolic phytochemical compound found in fresh ginger that activates heat receptors on the tongue. It is normally found as a pungent yellow oil in the ginger rhizome, but can also form a low-melting crystalline solid. This chemical compound is found in all members of the Zingiberaceae family and is high in concentrations in the grains of paradise as well as an African Ginger species. Cooking ginger transforms gingerol via a reverse aldol reaction into zingerone, which is less pungent and has a spicy-sweet aroma. When ginger is dried or mildly heated, gingerol undergoes a dehydration reaction forming shogaols, which are about twice as pungent as gingerol. This explains why dried ginger is more pungent than fresh ginger. Ginger also contains [8]-gingerol, [10]-gingerol, and [12]-gingerol, collectively deemed gingerols. Physiological potential In a pre-clinical meta-analysis of gingerol compounds anticancer, anti-inflammatory, anti-fungal, antioxidant, neuroprotective and gastroprotective properties were reported, which include studies in-vitro and in-vivo. A few in-vivo studies have proposed that gingerols facilitate healthy glucose regulation for diabetics. Many studies have been around the effects of gingerols on a wide range of cancers including leukemia, prostate, breast, skin, ovarian, lung, pancreatic and colorectal. There has not been much clinical testing to observe gingerols physiological impacts in humans. While many of the chemical mechanisms associated with the effects of gingerols on cells have been thoroughly studied, few have been in a clinical setting. This is due to the high variability in natural phytochemicals and the lack of efficacy in research. Most herbal medicine, which include gingerols, are under the restrictions of the Food and Drug Administration in the United States and experimental methods have not held up to scrutiny which has decreased the value in phytochemical research. Herbal medicine is untested fo
https://en.wikipedia.org/wiki/Jean-Raymond%20Abrial
Jean-Raymond Abrial (born 6 November 1938) is a French computer scientist and inventor of the Z and B formal methods. Abrial was a student at the École Polytechnique (class of 1958). Abrial's 1974 paper Data Semantics laid the foundation for a formal approach to Data Models; although not adopted directly by practitioners, it directly influenced all subsequent models from the Entity-Relationship Model through to RDF. J.-R. Abrial is the father of the Z notation (typically used for formal specification of software), during his time at the Programming Research Group under Prof. Tony Hoare within the Oxford University Computing Laboratory (now Oxford University Department of Computer Science), arriving in 1979 and sharing an office and collaborating with Cliff Jones. He later initiated the B-Method, with better tool-based software development support for refinement from a high-level specification to an executable program, including the Rodin tool. These are two important formal methods approaches for software engineering. He is the author of The B-Book: Assigning Programs to Meanings. For much of his career he has been an independent consultant. He was an invited professor at ETH Zurich from 2004 to 2009. Abrial was elected to be a Member of the Academia Europaea in 2006. See also Rodin tool
https://en.wikipedia.org/wiki/Hessian%20%28Web%20service%20protocol%29
Hessian is a binary Web service protocol that makes Web services usable without requiring a large framework, and without learning a new set of protocols . Because it is a binary protocol, it is well-suited to sending binary data without any need to extend the protocol with attachments. Hessian was developed by Caucho Technology, Inc. The company has released Java, Python and ActionScript for Adobe Flash implementations of Hessian under an open source license (the Apache license). Third-party implementations in several other languages (C++, C#, JavaScript, Perl, PHP, Ruby, Objective-C, D, and Erlang) are also available as open-source. Adaptations Although Hessian is primarily intended for Web services, it can be adapted for TCP traffic by using the HessianInput and HessianOutput classes in Caucho's Java implementation. Implementations Cotton (Erlang) HessDroid (Android) Hessian (on Rubyforge) (Ruby) Hessian.js (JavaScript) Hessian4J (Java) HessianC# (C#) HessianCPP (C++) HessianD (D) HessianKit (Objective-C 2.0) HessianObjC (Objective-C) HessianPHP (PHP) HessianPy (Python) HessianRuby (Ruby) Hessian-Translator (Perl) See also Abstract Syntax Notation One SDXF Apache Thrift Etch (protocol) Protocol Buffers Internet Communications Engine
https://en.wikipedia.org/wiki/Approach-avoidance%20conflict
Approach-avoidance conflicts as elements of stress were first introduced by psychologist Kurt Lewin, one of the founders of modern social psychology. Overview Approach-avoidance conflicts occur when there is one goal or event that has both positive and negative effects or characteristics that make the goal appealing and unappealing simultaneously. For example, marriage is a momentous decision that has both positive and negative aspects. The positive aspects, or approach portion, of marriage might be considered togetherness, sharing memories, and companionship while the negative aspects, or avoidance portions, might include financial considerations, arguments, and difficulty with in-laws. The negative effects of the decision help influence the decision maker to avoid the goal or event, while the positive effects influence the decision maker to want to approach or proceed with the goal or event. The influence of the negative and positive aspects create a conflict because the decision maker has to either proceed toward the goal or avoid the goal altogether. For example, the decision maker might approach proposing to a partner with excitement because of the positive aspects of marriage. On the other hand, they might avoid proposing due to the negative aspects of marriage. The decision maker might initiate approach toward the goal, but as awareness of the negative factors increases, the desire to avoid the goal may arise, producing indecision. If there are competing feelings to a goal, the stronger of the two will triumph. For instance, if a person was thinking of starting a business they would be faced with positive and negative aspects. Before actually starting the business, the person would be excited about the prospects of success for the new business and they would encounter (approach) the positive aspects first: they would attract investors, create interest in their upcoming ideas and it would be a new challenge. However, as they drew closer to actually launching
https://en.wikipedia.org/wiki/Mooncalf
A mooncalf (or moon-calf) is a monstrous birth, the abortive fetus of a cow or other farm animal. The term was occasionally applied to an abortive human fetus. The term derives from the once widespread superstition, present in many European folk traditions, that such malformed creatures were the product of the sinister influence of the Moon on fetal development. The earliest recorded use of the term was in 1565, referring to a human false pregnancy. Modern usage The term came to also refer to any monstrous or grotesque thing. Shakespeare, for instance, used the term to describe Caliban, the deformed servant of Prospero, in The Tempest. In H. G. Wells' 1901 novel The First Men in the Moon, large creatures domesticated by the Selenites are referred to as "mooncalves." Mooncalf is used as a derogatory term indicating someone is a dullard, fool or otherwise not particularly bright or sharp. For example, W. C. Fields in The Bank Dick (1940) advises his prospective son-in-law to avoid being a "mooncalf" by buying shares he has been conned into believing are worth much more than the proffered price. A mooncalf is also a magical creature in the world of the Harry Potter series. It is described in Fantastic Beasts and Where to Find Them as a shy, nocturnal creature with a smooth, pale-grey body, bulging eyes, and four spindly legs with large flat feet. Mooncalves perform dances in the moonlight and are apparently responsible for crop circles. In the film of the same name and its sequel, Newt Scamander's collection of creatures in his suitcase includes a herd of mooncalves. Wilfred Maxwell, narrator and protagonist of occultist Dion Fortune’s 1938 novel The Sea Priestess, refers several times to a mentally disabled character who falls into the sea and disappears as a "mooncalf". This concept is also used by Christian Morgenstern in his Galgenlieder. In Embassytown by China Miéville, the protagonist refers to two characters as "mooncalf and quite impossible." Arnold B
https://en.wikipedia.org/wiki/Deep%20reactive-ion%20etching
Deep reactive-ion etching (DRIE) is a highly anisotropic etch process used to create deep penetration, steep-sided holes and trenches in wafers/substrates, typically with high aspect ratios. It was developed for microelectromechanical systems (MEMS), which require these features, but is also used to excavate trenches for high-density capacitors for DRAM and more recently for creating through silicon vias (TSVs) in advanced 3D wafer level packaging technology. In DRIE, the substrate is placed inside a reactor, and several gases are introduced. A plasma is struck in the gas mixture which breaks the gas molecules into ions. The ions accelerated towards, and react with the surface of the material being etched, forming another gaseous element. This is known as the chemical part of the reactive ion etching. There is also a physical part, if ions have enough energy, they can knock atoms out of the material to be etched without chemical reaction. DRIE is a special subclass of RIE. There are two main technologies for high-rate DRIE: cryogenic and Bosch, although the Bosch process is the only recognised production technique. Both Bosch and cryo processes can fabricate 90° (truly vertical) walls, but often the walls are slightly tapered, e.g. 88° ("reentrant") or 92° ("retrograde"). Another mechanism is sidewall passivation: SiOxFy functional groups (which originate from sulphur hexafluoride and oxygen etch gases) condense on the sidewalls, and protect them from lateral etching. As a combination of these processes deep vertical structures can be made. Cryogenic process In cryogenic-DRIE, the wafer is chilled to −110 °C (163 K). The low temperature slows down the chemical reaction that produces isotropic etching. However, ions continue to bombard upward-facing surfaces and etch them away. This process produces trenches with highly vertical sidewalls. The primary issues with cryo-DRIE is that the standard masks on substrates crack under the extreme cold, plus etch by-p
https://en.wikipedia.org/wiki/Welwitschiaceae
Welwitschiaceae is a family of plants of the order Gnetales with one living species, Welwitschia mirabilis, found in southwestern Africa. Three fossil genera have been recovered from the Crato Formation – late Aptian (Lower Cretaceous) strata located in the Araripe Basin in northeastern Brazil, with one of these also being known from the early Late Cretaceous (Cenomanian-Turonian) Akrabou Formation of Morocco. Taxonomy German naturalist Friedrich Markgraf coined the name Welwitschiaceae in 1926, which appeared in Die Natürlichen Pflanzenfamilien. Most recent systems place the Welwitschiaceae in the gymnosperm order Gnetales. This order is most closely related to the order Pinales, which includes Araucariaceae - Araucarians, Cupressaceae - Cypress Family, Pinaceae - Pine Family, Podocarpaceae - Podocarps, Sciadopityaceae - Koyamaki Family (the sole member Sciadopitys verticillata - Koyamaki), Taxaceae - Yew Family. Genetic analyses indicate that the Gnetales arose from within the conifer group, and any morphological similarities between angiosperms and Gnetales have evolved separately.<ref>Chaw S-M., C.L. Parkinson, Y. Cheng, T.M. Vincent and J. D. Palmer (2000) Seed plant phylogeny inferred from all three plant genomes: Monophyly of extant gymnosperms and origin of Gnetales from conifers Proceedings of the National Academy of Sciences of the United States of America 97:4086–4091</ref> The ancestors of the extant gymnosperm orders—Gnetales, Coniferales, Cycadales and Ginkgoales—arose during the Late Paleozoic, and became the dominant component of the Late Permian and Mesozoic flora. Living species The family contains a single genus and single extant species, Welwitschia mirabilis, which lives in the Kaokoveld Desert of Angola and Namibia in southwestern Africa. Fossil species Fossil evidence indicates that members of the Welwitschiaceae were present in South America during the Early Cretaceous (Mesozoic era). Priscowelwitschia austroamericana (initially named
https://en.wikipedia.org/wiki/Formulario%20mathematico
Formulario Mathematico (Latino sine flexione: Formulary for Mathematics) is a book by Giuseppe Peano which expresses fundamental theorems of mathematics in a symbolic language developed by Peano. The author was assisted by Giovanni Vailati, Mario Pieri, Alessandro Padoa, Giovanni Vacca, Vincenzo Vivanti, Gino Fano and Cesare Burali-Forti. The Formulario was first published in 1894. The fifth and last edition was published in 1908. Hubert Kennedy wrote "the development and use of mathematical logic is the guiding motif of the project". He also explains the variety of Peano's publication under the title: the five editions of the Formulario [are not] editions in the usual sense of the word. Each is essentially a new elaboration, although much material is repeated. Moreover, the title and language varied: the first three, titled Formulaire de Mathématiques, and the fourth, titled, Formulaire Mathématique, were written in French, while Latino sine flexione, Peano's own invention, was used for the fifth edition, titled Formulario Mathematico. ... Ugo Cassina lists no less than twenty separately published items as being parts of the 'complete' Formulario! Peano believed that students needed only precise statement of their lessons. He wrote: Each professor will be able to adopt this Formulario as a textbook, for it ought to contain all theorems and all methods. His teaching will be reduced to showing how to read the formulas, and to indicating to the students the theorems that he wishes to explain in his course. Such a dismissal of the oral tradition in lectures at universities was the undoing of Peano's own teaching career. Notes
https://en.wikipedia.org/wiki/Red-eye%20gravy
Red-eye gravy is a thin sauce often seen in the cuisine of the Southern United States and associated with the country ham of that region. Other names for this sauce include poor man's gravy, bird-eye gravy, bottom sop, cedar gravy, and red ham gravy. The gravy is made from the drippings of pan-fried country ham mixed with black coffee. Red-eye gravy is often served over ham, grits or biscuits. A common practice is to dip the inner sides of a split biscuit into the gravy in order to add flavor and keep the biscuit from being too dry when a piece of country ham is added between the two halves, sometimes called the Southern "ham biscuit". (The Appalachian ham biscuit is simply a biscuit with country ham.) Another popular way to serve red-eye gravy, especially in parts of Alabama, is with mustard or ketchup mixed in with the gravy. Biscuits are then dipped in the gravy. In Louisiana, Cajun cuisine-style gravy is made with a roast beef instead of ham. Black coffee is always used, and it is frequently a strongly brewed coffee substitute made from chicory. The gravy is ladled over the meat on a bed of rice, staining the rice a dark brown color. Often, French bread and some kind of beans, like butter beans, lima beans, or peas, are served as side dishes. Origin Red-eye gravy's name comes from its distinct appearance. Prepared traditionally, with coffee and grease combined in the final step (see Preparation below), a heterogeneous mixture forms with the water-based coffee sinking to the bottom and the oil-based grease forming the top layer. In a round bowl the mixture looks much like a red human eye. Use of red pepper enhances the redness of the appearance. Less traditional preparation techniques do not always result in the "red eye" appearance, leading to folk legends surrounding the origin of the name. For instance, one story is that former United States President Andrew Jackson requested ham with gravy as red as his cook's eyes, which were bloodshot from drinking the
https://en.wikipedia.org/wiki/Simplicial%20manifold
In physics, the term simplicial manifold commonly refers to one of several loosely defined objects, commonly appearing in the study of Regge calculus. These objects combine attributes of a simplex with those of a manifold. There is no standard usage of this term in mathematics, and so the concept can refer to a triangulation in topology, or a piecewise linear manifold, or one of several different functors from either the category of sets or the category of simplicial sets to the category of manifolds. A manifold made out of simplices A simplicial manifold is a simplicial complex for which the geometric realization is homeomorphic to a topological manifold. This is essentially the concept of a triangulation in topology. This can mean simply that a neighborhood of each vertex (i.e. the set of simplices that contain that point as a vertex) is homeomorphic to a n-dimensional ball. A simplicial object built from manifolds A simplicial manifold is also a simplicial object in the category of manifolds. This is a special case of a simplicial space in which, for each n, the space of n-simplices is a manifold. For example, if G is a Lie group, then the simplicial nerve of G has the manifold as its space of n-simplices. More generally, G can be a Lie groupoid. Structures on manifolds Simplicial sets
https://en.wikipedia.org/wiki/Extra-low%20voltage
Extra-low voltage (ELV) is an electricity supply voltage and is a part of the Low voltage band in a range which carries a low risk of dangerous electrical shock. There are various standards that define extra-low voltage. The International Electrotechnical Commission (IEC) and the UK IET (BS 7671:2008) define an ELV device or circuit as one in which the electrical potential between two conductors or between an electrical conductor and earth (ground) does not exceed 50V AC or 120V DC (ripple free). The IEC and IET go on to define actual types of extra-low voltage systems, for example separated extra-low voltage (SELV), protected extra-low voltage (PELV), functional extra-low voltage (FELV). These can be supplied using sources including motor / fossil fuel generator sets, transformers, switched PSU's or rechargeable battery. SELV, PELV, FELV, are distinguished by various safety properties, supply characteristics and design voltages. Some types of landscape lighting use SELV / PELV (extra-low voltage) systems. Modern battery operated hand tools fall in the SELV category. In more arduous conditions 25 volts RMS alternating current / 60 volts (ripple-free) direct current can be specified to further reduce hazard. Lower voltage can apply in wet or conductive conditions where there is even greater potential for electric shock. These systems should still fall under the SELV / PELV (ELV) safety specifications. Types Separated or safety extra-low voltage (SELV) IEC defines a SELV system as "an electrical system in which the voltage cannot exceed ELV under normal conditions, and under single-fault conditions, including earth faults in other circuits". It is generally accepted that the acronym: SELV stands for separated extra-low voltage (separated from earth) as defined in installation standards (e.g. BS 7671), though BS EN 60335 refers to it as safety extra-low voltage. A SELV circuit must have: Electrical protective-separation (i.e., double insulation, reinforced insula
https://en.wikipedia.org/wiki/Znamenny%20chant
Znamenny Chant () is a singing tradition used by some in the Russian Eastern Orthodox Church. Znamenny Chant is a unison, melismatic liturgical singing that has its own specific notation, called the notation. The symbols used in the notation are called (, 'hooks') or (, 'signs'). Often the names of the signs are used to refer to the notation. Znamenny melodies are part of a system, consisting of 'eight tones' (intonation structures; called ); the melodies are characterized by fluency and balance. There exist several types of Znamenny Chant: the so-called , (Little) and (Great) Znamenny Chant. Ruthenian Chant (Prostopinije) is sometimes considered a sub-division of the Znamenny Chant tradition, with the Russian Chant (Znamenny Chant proper) being the second branch of the same musical continuum. Notation Znamenny Chants are not written with notes (the so-called 'linear notation'), but with special signs, called (Russian for "marks", "banners") or ("hooks"), as some shapes of these signs resemble hooks. Each sign may include the following components: a large black hook or a black stroke, several smaller black 'points' and 'commas' and lines near the hook or crossing the hook. Some signs may mean only one note, some 2 to 4 notes, and some a whole melody of more than 10 notes with a complicated rhythmic structure. The most notable feature of this notation system is that it records transitions of the melody, rather than notes. The signs also represent a mood and a gradation of how this part of melody is to be sung (tempo, strength, devotion, meekness, etc.) Every sign has its own name and also features as a spiritual symbol. For example, there is a specific sign, called "little dove" (, ), which represents two rising sounds and is also a symbol of the Holy Ghost. Development The notation was developed in Kievan Rus' as an East Slavic refinement of the Byzantine neumatic musical notation. After 13th century, the Znamenny Chant and notation continued to dev
https://en.wikipedia.org/wiki/Adenochlaena
Adenochlaena is a genus of plant of the family Euphorbiaceae first described as a genus in 1858. It is native to certain islands in the Indian Ocean. Species Adenochlaena leucocephala Baill. - Madagascar, Comoros Adenochlaena zeylanica (Baill.) Thwaites - Sri Lanka formerly included moved to other genera (Cladogynos Epiprinus Koilodepas ) A. calycina - Koilodepas calycinum A. indica - Epiprinus mallotiformis A. mallotiformis - Epiprinus mallotiformis A. siamensis - Cladogynos orientalis A. siletensis - Epiprinus siletianus
https://en.wikipedia.org/wiki/Cosmic%20ray%20spallation
Cosmic ray spallation, also known as the x-process, is a set of naturally occurring nuclear reactions causing nucleosynthesis; it refers to the formation of chemical elements from the impact of cosmic rays on an object. Cosmic rays are highly energetic charged particles from beyond Earth, ranging from protons, alpha particles, and nuclei of many heavier elements. About 1% of cosmic rays also consist of free electrons. Cosmic rays cause spallation when a ray particle (e.g. a proton) impacts with matter, including other cosmic rays. The result of the collision is the expulsion of particles (protons, neutrons, and alpha particles) from the object hit. This process goes on not only in deep space, but in Earth's upper atmosphere and crustal surface (typically the upper ten meters) due to the ongoing impact of cosmic rays. The process Cosmic ray spallation is thought to be responsible for the abundance in the universe of some light elements—lithium, beryllium, and boron—as well as the isotope helium-3. This process (cosmogenic nucleosynthesis) was discovered somewhat by accident during the 1970s: models of Big Bang nucleosynthesis suggested that the amount of deuterium was too large to be consistent with the expansion rate of the universe and there was therefore great interest in processes that could generate deuterium after the Big Bang nucleosynthesis. Cosmic ray spallation was investigated as a possible process to generate deuterium. As it turned out, spallation could not generate much deuterium, but the new studies of spallation showed that this process could generate lithium, beryllium and boron; indeed, isotopes of these elements are over-represented in cosmic ray nuclei, as compared with solar atmospheres (whereas hydrogen and helium are present in about primordial ratios in cosmic rays). An example of cosmic ray spallation is a neutron hitting a nitrogen-14 nucleus in the earth's atmosphere, yielding a proton, an alpha particle, and a beryllium-10 nucleus, wh
https://en.wikipedia.org/wiki/Percolation%20test
A percolation test (colloquially called a perc test) is a test to determine the water absorption rate of soil (that is, its capacity for percolation) in preparation for the building of a septic drain field (leach field) or infiltration basin. The results of a percolation test are required to properly design a septic system. In its broadest terms, percolation testing is simply observing how quickly a known volume of water dissipates into the subsoil of a drilled hole of known surface area. While every jurisdiction will have its own laws regarding the exact calculations for the length of line, depth of pit, etc., the testing procedures are the same. In general, sandy soil will absorb more water than soil with a high concentration of clay or where the water table is close to the surface. Testing method A percolation test consists of digging one or more holes in the soil of the proposed leach field to a specified depth, presoaking the holes by maintaining a high water level in the holes, then running the test by filling the holes to a specific level and timing the drop of the water level as the water percolates into the surrounding soil. There are various empirical formulae for determining the required size of a leach field based on the size of facility, the percolation test results, and other parameters. For leach line testing, a minimum of three test holes are drilled or dug by hand, most commonly six to eight inches in diameter. Ideally, these should be drilled to different depths from three to six feet below the surface. For better, more conclusive results, five drill holes are used in a pattern of one hole at each corner of the proposed leach field and one test hole in the center. Testing of these holes will result in a value with units of minutes per inch. This value is then correlated to a predetermined county health code to establish the exact size of the leach field. Testing for horizontal pits typically requires five to eight test holes drilled in a
https://en.wikipedia.org/wiki/Maemo
Maemo is a software platform originally developed by Nokia, now developed by the community, for smartphones and Internet tablets. The platform comprises both the Maemo operating system and SDK. Maemo played a key role in Nokia's strategy to compete with Apple and Android, and that strategy failed for complex, institutional and strategic reasons. Maemo is mostly based on open-source code and has been developed by Maemo Devices within Nokia in collaboration with many open-source projects such as the Linux kernel, Debian, and GNOME. Maemo is based on Debian and draws much of its GUI, frameworks, and libraries from the GNOME project. It uses the Matchbox window manager and the GTK-based Hildon framework as its GUI and application framework. The user interface in Maemo 4 is similar to many hand-held interfaces and features a "home" screen, from which all applications and settings are accessed. The home screen is divided into areas for launching applications, a menu bar, and a large customizable area that can display information such as an RSS reader, Internet radio player, and Google search box. The Maemo 5 user interface is slightly different; the menu bar and info area are consolidated to the top of the display, and the four desktops can be customized with shortcuts and widgets. At the Mobile World Congress in February 2010, it was announced that the Maemo project would be merging with Moblin to create the MeeGo mobile software platform. Despite that, the Maemo community continued to be active, and in late 2012 Nokia began transferring Maemo ownership to the Hildon Foundation, which was replaced by a German association Maemo Community e.V. Since 2017, a new release called Maemo Leste is in development which is based on Devuan. User interface OS2005–OS2008 Up to Maemo 4 (AKA OS2008), the default screen is the "Home" screen — the central point from which all applications and settings are accessed. The Home Screen is divided into the following areas: Vertically d
https://en.wikipedia.org/wiki/Broad%20Institute
The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: , pronunciation respelling: ), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States. The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it partners with the Massachusetts Institute of Technology, Harvard University, and the five Harvard teaching hospitals. History The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer and human genetics. Another cornerstone was the Institute of Chemistry and Cell Biology established by Harvard Medical School in 1998 to pursue chemical genetics as an academic discipline. Its screening facility was one of the first high-throughput resources opened in an academic setting. It facilitated small molecule screening projects for more than 80 research groups worldwide. To create a new organization that was open, collaborative, cross-disciplinary and able to organize projects at any scale, planning took place in 2002–2003 among philanthropists Eli and Edythe Broad, MIT, the Whitehead Institute, Harvard and the Harvard-affiliated hospitals (in particular, the Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Children's Hospital Boston, the Dana–Farber Cancer Institute and the Massachusetts General Hospital). The Broads made a founding gift of $100 million and the Broad Institute was formally launched in May 2004. In November 2005, the Broads announced an additional $100
https://en.wikipedia.org/wiki/Nordstr%C3%B6m%27s%20theory%20of%20gravitation
In theoretical physics, Nordström's theory of gravitation was a predecessor of general relativity. Strictly speaking, there were actually two distinct theories proposed by the Finnish theoretical physicist Gunnar Nordström, in 1912 and 1913 respectively. The first was quickly dismissed, but the second became the first known example of a metric theory of gravitation, in which the effects of gravitation are treated entirely in terms of the geometry of a curved spacetime. Neither of Nordström's theories are in agreement with observation and experiment. Nonetheless, the first remains of interest insofar as it led to the second. The second remains of interest both as an important milestone on the road to the current theory of gravitation, general relativity, and as a simple example of a self-consistent relativistic theory of gravitation. As an example, this theory is particularly useful in the context of pedagogical discussions of how to derive and test the predictions of a metric theory of gravitation. Development of the theories Nordström's theories arose at a time when several leading physicists, including Nordström in Helsinki, Max Abraham in Milan, Gustav Mie in Greifswald, Germany, and Albert Einstein in Prague, were all trying to create competing relativistic theories of gravitation. All of these researchers began by trying to suitably modify the existing theory, the field theory version of Newton's theory of gravitation. In this theory, the field equation is the Poisson equation , where is the gravitational potential and is the density of matter, augmented by an equation of motion for a test particle in an ambient gravitational field, which we can derive from Newton's force law and which states that the acceleration of the test particle is given by the gradient of the potential This theory is not relativistic because the equation of motion refers to coordinate time rather than proper time, and because, should the matter in some isolated object sudden
https://en.wikipedia.org/wiki/Colonisation%20%28biology%29
Colonisation or colonization is the process in biology by which a species spreads to new areas. Colonisation often refers to successful immigration where a population becomes integrated into an ecological community, having resisted initial local extinction. In ecology, it is represented by the symbol λ (lowercase lambda) to denote the long-term intrinsic growth rate of a population. One classic scientific model in biogeography posits that a species must continue to colonize new areas through its life cycle (called a taxon cycle) in order to achieve longevity. Accordingly, colonisation and extinction are key components of island biogeography, a theory that has many applications in ecology, such as metapopulations. Scale Colonisation occurs on several scales. In the most basic form, as biofilm in the formation of communities of microorganisms on surfaces. In small scales such as colonising new sites, perhaps as a result of environmental change. And on larger scales where a species expands its range to encompass new areas. This can be via a series of small encroachments, such as in woody plant encroachment, or by long-distance dispersal. The term range expansion is also used. Use The term is generally only used to refer to the spread of a species into new areas by natural means, as opposed to unnatural introduction or translocation by humans, which may lead to invasive species. Colonisation events Large-scale notable pre-historic colonisation events include: Arthropods the colonisation of the earth's land by the first animals, the arthropods. The first fossils of land animals come from millipedes. These were seen about 450 million years ago (Dunn, 2013). Humans the early human migration and colonisation of areas outside Africa according to the recent African origin paradigm, resulting in the extinction of Pleistocene megafauna, although the role of humans in this event is controversial. Some large-scale notable colonisation events during the 20th century are: