anchor_id stringlengths 8 8 | anchor_title stringlengths 22 248 | anchor_abstract stringlengths 73 4.05k | positive_pool listlengths 1 1 | negative_pool listlengths 1 1 |
|---|---|---|---|---|
22509163 | Targets for a comparative neurobiology of language. | One longstanding impediment to progress in understanding the neural basis of language is the development of model systems that retain language-relevant cognitive behaviors yet permit invasive cellular neuroscience methods. Recent experiments in songbirds suggest that this group may be developed into a powerful animal m... | [
[
"10378865",
"Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.",
"Substance P (SP) plays a major role in the regulation of the interaction between immune and nervous systems. SP administration stimulates... | [
[
"23264884",
"Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.",
"Adverse, unfavourable life conditions, particularly during early life stages and infancy, can lead to epigenetic regulation of genes involved in stress-response, behavioral disinhibition, and cognitive-em... |
23195310 | Model organism databases in behavioral neuroscience. | Model Organism Databases (MODs) are an important informatics tool for researchers. They provide comprehensive organism specific genetic, genomic, and phenotype datasets. MODs ensure accurate data identification and integrity and provide official nomenclature for genes, Quantitative Trait Loci, and strains. Most importa... | [
[
"19254758",
"Re-exposure to endotoxin induces differential cytokine gene expression in the rat hypothalamus and spleen.",
"This study was designed to investigate whether the pattern of hypothalamic and splenic cytokine expression induced by peripheral administration of a bacterial lipopolysaccharide (... | [
[
"23181017",
"Support vector machines for spike pattern classification with a leaky integrate-and-fire neuron.",
"Spike pattern classification is a key topic in machine learning, computational neuroscience, and electronic device design. Here, we offer a new supervised learning rule based on Support Vec... |
23372986 | Experience with multimodality telepathology at the University of Pittsburgh Medical Center. | Several modes of telepathology exist including static (store-and-forward), dynamic (live video streaming or robotic microscopy), and hybrid technology involving whole slide imaging (WSI). Telepathology has been employed at the University of Pittsburgh Medical Center (UPMC) for over a decade at local, national, and inte... | [
[
"3974835",
"Bilateral traumatic abducens nerve palsy without skull fracture and with cervical spine fracture: case report and review of the literature.",
"Bilateral traumatic abducens nerve palsy is a rare condition. Here a case without skull fracture and associated with cervical spine fracture is rep... | [
[
"23193602",
"Arthropod venoms: a vast arsenal of insecticidal neuropeptides.",
"Arthropods are the most diverse animal group on the planet, and occupy almost all ecological niches. Venomous arthropods are a rich source of bioactive compounds evolved for prey capture and defense against predators and/o... |
23060761 | A computational approach to "free will" constrained by the games we play. | Human choice is not free-we are bounded by a multitude of biological constraints. Yet, within the various landscapes we face, we do express choice, preference, and varying degrees of so-called willful behavior. Moreover, it appears that the capacity for choice in humans is variable. Empirical studies aimed at investiga... | [
[
"19400719",
"The science of neural interface systems.",
"The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of n... | [
[
"24294562",
"Dorello's Canal and Gruber's Ligament: Historical Perspective.",
"Wenzel Leopold Gruber and Primo Dorello were great anatomists and researchers during the 19th and 20th centuries. Their contributions to neuroanatomy-namely the Gruber's (petrosphenoidal) ligament and Dorello's canal, respe... |
23035093 | Optimization of a GCaMP calcium indicator for neural activity imaging. | Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been deployed in a number of model organisms and can reliably detect three or ... | [
[
"19064491",
"Retention of high tactile acuity throughout the life span in blindness.",
"Previous studies of tactile acuity on the fingertip, using passive touch, have demonstrated an age-related decline in spatial resolution for both sighted and blind subjects. We have reexamined this age dependence w... | [
[
"23033443",
"Apraxia of speech: concepts and controversies.",
"This article was written as an editorial to a collection of original articles on apraxia of speech (AOS) in which some of the more recent advancements in the understanding of this syndrome are discussed. It covers controversial issues conc... |
23055482 | Towards a new neurobiology of language. | Theoretical advances in language research and the availability of increasingly high-resolution experimental techniques in the cognitive neurosciences are profoundly changing how we investigate and conceive of the neural basis of speech and language processing. Recent work closely aligns language research with issues at... | [
[
"21748284",
"A failure to normalize biochemical and metabolic insults during morphine withdrawal disrupts synaptic repair in mice transgenic for HIV-gp120.",
"Drug abuse in HIV-infected individuals accelerates the onset and progression of HIV-associated neurocognitive disorders (HAND). Opiates are a c... | [
[
"23195316",
"Opportunities for bioinformatics in the classification of behavior and psychiatric disorders.",
"A bioinformatics approach to behavioral neuroscience provides both unique opportunities and challenges for research on behavior. A major challenge has been to describe, define, and discriminat... |
23505339 | Baby Steps to Superintelligence: Neuroprosthetics and Children. | Children surviving neural injuries face challenges not seen by their adult counterparts, namely that they experience neural injury before reaching neurodevelopmental maturity. Neural prostheses offer one possible path to recovery, along with the potential for functional outcomes that could exceed expectations. Although... | [
[
"12951145",
"Structure and function of the vomeronasal system: an update.",
"Several developments during the past 15 years have profoundly affected our understanding of the vomeronasal system (VNS) of vertebrates. In the mid 1990s, the vomeronasal epithelium of mammals was found to contain two populat... | [
[
"22850833",
"Complex biomedical systems: from basic science to translation.",
"The Department of Biomedical Engineering (BME) of the University of Southern California (BME@USC) has a longstanding tradition of advancing biomedicine through the development and application of novel engineering ideas. Mor... |
23176028 | Iranians' contribution to world literature on neuroscience. | The purpose of this study is to analyse Iranian scientific publications in the neuroscience subfields by librarians and neuroscientists, using Science Citation Index Expanded (SCIE) via Web of Science data over the period, 2002-2008.</AbstractText Data were retrieved from the SCIE. Data were collected from the 'subject... | [
[
"21312401",
"Functional brain imaging in schizophrenia: selected results and methods.",
"Functional brain imaging studies of patients with schizophrenia may be grouped into those that assume that the signs and symptoms of schizophrenia are due to disordered circuitry within a critical brain region and... | [
[
"22963524",
"Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4 in precision cut lung slices in the horse.",
"Glucocorticoids have been proven to be effective in the therapy of recurrent airway obstruction (RAO) in horses via systemic as well as local (in... |
23174433 | When do people cooperate? The neuroeconomics of prosocial decision making. | Understanding the roots of prosocial behavior is an interdisciplinary research endeavor that has generated an abundance of empirical data across many disciplines. This review integrates research findings from different fields into a novel theoretical framework that can account for when prosocial behavior is likely to o... | [
[
"12716950",
"Hierarchical processing in spoken language comprehension.",
"Understanding spoken language requires a complex series of processing stages to translate speech sounds into meaning. In this study, we use functional magnetic resonance imaging to explore the brain regions that are involved in ... | [
[
"23001148",
"An observational study of the effectiveness and safety of growth hormone (Humatrope(®)) treatment in Japanese children with growth hormone deficiency or Turner syndrome.",
"This study assessed the effectiveness and safety of growth hormone (GH; Humatrope(®)) therapy in Japanese child... |
22240730 | Birdsong neurolinguistics: songbird context-free grammar claim is premature. | There are remarkable behavioral, neural, and genetic similarities between song learning in songbirds and speech acquisition in human infants. Previously, we have argued that this parallel cannot be extended to the level of sentence syntax. Although birdsong can indeed have a complex structure, it lacks the combinatoria... | [
[
"19400719",
"The science of neural interface systems.",
"The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of n... | [
[
"23351052",
"On the neural basis of rule-guided behavior.",
"Human behavior emerges from a complex dynamic interaction between graded and context-sensitive neural processes, the biomechanics of our bodies, and the vicissitudes of our environments. These coupled processes bear little resemblance to the... |
21645998 | Are we studying and treating schizophrenia correctly? | New findings are rapidly revealing an increasingly detailed image of neural- and molecular-level dysfunction in schizophrenia, distributed throughout interconnected cortico-striato-pallido-thalamic circuitry. Some disturbances appear to reflect failures of early brain maturation, that become codified into dysfunctional... | [
[
"15996748",
"Correlates of trait impulsiveness in performance measures and neuropsychological tests.",
"Performance measures of impulsiveness offer great promise for assessing this trait in clinical and experimental studies. However, little is known about their relative superiority or inferiority to s... | [
[
"21625624",
"\"Studying injured minds\" - the Vietnam head injury study and 40 years of brain injury research.",
"The study of those who have sustained traumatic brain injuries (TBI) during military conflicts has greatly facilitated research in the fields of neuropsychology, neurosurgery, psychiatry, ... |
23062307 | Childhood adversity and DNA methylation of genes involved in the hypothalamus-pituitary-adrenal axis and immune system: whole-genome and candidate-gene associations. | In recent years, translational research involving humans and animals has uncovered biological and physiological pathways that explain associations between early adverse circumstances and long-term mental and physical health outcomes. In this article, we summarize the human and animal literature demonstrating that epige... | [
[
"15831717",
"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.",
"Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and th... | [
[
"23576843",
"Possibilities offered by implantable miniaturized cuff-electrodes for insect neurophysiology.",
"Recent advances in microsystems technology led to a miniaturization of cuff-electrodes, which suggests these electrodes not just for long-term neuronal recordings in mammalians, but also in me... |
23196557 | [A new neuroscientific approach using decoded neurofeedback (DecNef)]. | Neurofeedback is defined as a method to read out information from the brain and feed the information back to the brain. This technology has developed in the past ten years and attracted considerable attention as potential treatments for rehabilitation and psychiatric disease. We recently invented the decoded neurofeedb... | [
[
"15831717",
"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.",
"Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and th... | [
[
"23176028",
"Iranians' contribution to world literature on neuroscience.",
"The purpose of this study is to analyse Iranian scientific publications in the neuroscience subfields by librarians and neuroscientists, using Science Citation Index Expanded (SCIE) via Web of Science data over the period, 200... |
23428294 | Neuropsychological assessment and the paradox of ADHD. | Attention-deficit hyperactivity disorder (ADHD) is a behaviorally defined diagnosis. Despite the fact that neuropsychological tests have typically been used successfully to investigate the functional neuroanatomy of ADHD in neuroimaging research paradigms, these tests have been of surprisingly limited utility in the cl... | [
[
"21325522",
"Origin and determination of inhibitory cell lineages in the vertebrate retina.",
"Multipotent progenitors in the vertebrate retina often generate clonally related mixtures of excitatory and inhibitory neurons. The postmitotically expressed transcription factor, Ptf1a, is essential for all... | [
[
"23275858",
"Brain state-triggered stimulus delivery: An efficient tool for probing ongoing brain activity.",
"What is the relationship between variability in ongoing brain activity <i"
]
] |
22520647 | European study of research and development in mobility technology for persons with disabilities. | \In the fall of 2010, the National Science Foundation, the National Institutes of Health and the U.S. Veteran's Administration jointly supported a review of mobility technology in Europe. A delegation of American Scientists traveled to Europe to visit a number of research centers and engaged in a demonstration and dial... | [
[
"20427643",
"Emotional automaticity is a matter of timing.",
"There has been a long controversy concerning whether the amygdala's response to emotional stimuli is automatic or dependent on attentional load. Using magnoencephalography and an advanced beamformer source localization technique, we found t... | [
[
"22155385",
"Metabotropic glutamate receptor 1 (mGluR1): antibody specificity and receptor expression in cultured primary neurons.",
"The availability of high quality, well-characterized antibodies for molecular and cellular neuroscience studies is important. However, not all available antibodies are ... |
22751865 | Human aquaporin 4281-300 is the immunodominant linear determinant in the context of HLA-DRB1*03:01: relevance for diagnosing and monitoring patients with neuromyelitis optica. | OBJECTIVE To identify linear determinants of human aquaporin 4 (hAQP4) in the context of HLA-DRB1*03:01. DESIGN In this controlled study with humanized experimental animals, HLA-DRB1*03:01 transgenic mice were immunized with whole-protein hAQP4 emulsified in complete Freund adjuvant. To test T-cell responses, lymph nod... | [
[
"21731699",
"Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.",
"Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the S... | [
[
"24294562",
"Dorello's Canal and Gruber's Ligament: Historical Perspective.",
"Wenzel Leopold Gruber and Primo Dorello were great anatomists and researchers during the 19th and 20th centuries. Their contributions to neuroanatomy-namely the Gruber's (petrosphenoidal) ligament and Dorello's canal, respe... |
23276394 | Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. | Chromosomal deletions at Xp22.3 appear to influence vulnerability to the neurodevelopmental disorders attention deficit hyperactivity disorder (ADHD) and autism. 39,X(Y*)O mice, which lack the murine orthologue of the Xp22.3 ADHD candidate gene STS (encoding steroid sulfatase), exhibit behavioural phenotypes relevant t... | [
[
"18457512",
"Timing, storage, and comparison of stimulus duration engage discrete anatomical components of a perceptual timing network.",
"The temporal discrimination paradigm requires subjects to compare the duration of a probe stimulus to that of a sample previously stored in working or long-term me... | [
[
"23269483",
"Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey.",
"Iron deficiency anemia affects many pregnant women and young infants worldwide. The health impact is significant, given iron's known role in many body func... |
23130007 | When Do We Confuse Self and Other in Action Memory? Reduced False Memories of Self-Performance after Observing Actions by an Out-Group vs. In-Group Actor. | Observing another person performing an action can lead to a false memory of having performed the action oneself - the observation-inflation effect. In the experimental paradigm, participants first perform or do not perform simple actions, and then observe another person perform some of these actions. The observation-in... | [
[
"19298949",
"Perceptual simulation in conceptual combination: evidence from property generation.",
"In three experiments, participants received nouns or noun phrases for objects and verbally generated their properties (\"feature listing\"). Several sources of evidence indicated that participants const... | [
[
"23055968",
"Detection of self-paced reaching movement intention from EEG signals.",
"Future neuroprosthetic devices, in particular upper limb, will require decoding and executing not only the user's intended movement type, but also when the user intends to execute the movement. This work investigates... |
23279177 | Neurochemistry of schizophrenia: the contribution of neuroimaging postmortem pathology and neurochemistry in schizophrenia. | The advent of molecular neuroimaging has greatly impacted on understanding the neurochemical changes occurring in the CNS from subjects with psychiatric disorders, especially schizophrenia. This review focuses on the outcomes from studies using positron emission tomography and single photon emission computer tomography... | [
[
"11330208",
"Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.",
"Recent work indicates that the orexin/hypocretin-containing neurons of the lateral hypothalamus are involved in control of REM sleep phenomena, but site-specific actions in control... | [
[
"22986407",
"How a common variant in the growth factor receptor gene, NTRK1, affects white matter.",
"Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated ... |
23197532 | A large-scale model of the functioning brain. | A central challenge for cognitive and systems neuroscience is to relate the incredibly complex behavior of animals to the equally complex activity of their brains. Recently described, large-scale neural models have not bridged this gap between neural activity and biological function. In this work, we present a 2.5-mill... | [
[
"8854339",
"Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker.",
"A pair of conserved methionine residues, located on the cytoplasmic linker between segments S4 and S5 in the fourth domain of human heart Na channels (hH1), plays a role in the kinetics a... | [
[
"23505339",
"Baby Steps to Superintelligence: Neuroprosthetics and Children.",
"Children surviving neural injuries face challenges not seen by their adult counterparts, namely that they experience neural injury before reaching neurodevelopmental maturity. Neural prostheses offer one possible path to r... |
22143364 | Postural tachycardia syndrome--current experience and concepts. | Postural tachycardia syndrome (PoTS) is a poorly understood but important cause of orthostatic intolerance resulting from cardiovascular autonomic dysfunction. PoTS is distinct from the syndromes of autonomic failure usually associated with orthostatic hypotension, such as pure autonomic failure and multiple system atr... | [
[
"21749952",
"Social neuroscience: mirror neurons recorded in humans.",
"New single-cell recordings show that humans do have mirror neurons, and in more brain regions than previously suspected. Some action-execution neurons were seen to be inhibited during observation, possibly preventing imitation and... | [
[
"21960308",
"Open questions in computational motor control.",
"Computational motor control covers all applications of quantitative tools for the study of the biological movement control system. This paper provides a review of this field in the form of a list of open questions. After an introduction in... |
22481743 | Brain enabled by next-generation neurotechnology: using multiscale and multimodal models. | As many articles in this issue of IEEE Pulse demonstrate, interfacing directly with the brain presents several fundamental challenges. These challenges reside at multiple levels and span many disciplines, ranging from the need to understand brain states at the level of neural circuits to creating technological innovati... | [
[
"15928068",
"Reward, motivation, and emotion systems associated with early-stage intense romantic love.",
"Early-stage romantic love can induce euphoria, is a cross-cultural phenomenon, and is possibly a developed form of a mammalian drive to pursue preferred mates. It has an important influence on so... | [
[
"22963990",
"Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichment.",
"Aberrant repetitive behaviors are commonly observed in a variety of neurodevelopmental, neurological, and neuropsychiatric disorders. Little is known about the... |
23493966 | Exploring sensory neuroscience through experience and experiment. | Many phenomena that we take for granted are illusions - color and motion on a TV or computer monitor, for example, or the impression of space in a stereo music recording. Even the stable image that we perceive when looking directly at the real world is illusory. One of the important lessons from sensory neuroscience is... | [
[
"11377409",
"Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling.",
"The authors' goal was to assess the efficacy and tolerability of naltrexone in the treatment of pathologic gambling disorder.</AbstractText Eighty-three subjects who met criteria for DSM-IV ... | [
[
"23140422",
"Comparison of GPU- and CPU-implementations of mean-firing rate neural networks on parallel hardware.",
"Modern parallel hardware such as multi-core processors (CPUs) and graphics processing units (GPUs) have a high computational power which can be greatly beneficial to the simulation of l... |
23177656 | Synthetic event-related potentials: a computational bridge between neurolinguistic models and experiments. | Our previous work developed Synthetic Brain Imaging to link neural and schema network models of cognition and behavior to PET and fMRI studies of brain function. We here extend this approach to Synthetic Event-Related Potentials (Synthetic ERP). Although the method is of general applicability, we focus on ERP correlate... | [
[
"17691351",
"An introduction to operative neuromodulation and functional neuroprosthetics, the new frontiers of clinical neuroscience and biotechnology.",
"Operative neuromodulation is the field of altering electrically or chemically the signal transmission in the nervous system by implanted devices i... | [
[
"23269439",
"The p.Ala510Val mutation in the SPG7 (paraplegin) gene is the most common mutation causing adult onset neurogenetic disease in patients of British ancestry.",
"The c.1529C >T change in the SPG7 gene, encoding the mutant p.Ala510Val paraplegin protein, was first described as a polymorph... |
22814704 | Inflammation in anxiety. | The idea of the existence of an interaction between the immune system and the central nervous system (CNS) has prompted extensive research interest into the subject of "Psychoneuroimmunology" taking the field to an interesting level where new hypotheses are being increasingly tested. Specifically, exactly how the cross... | [
[
"17670965",
"Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo.",
"Cortical gamma oscillations contribute to cognitive processing and are thought to be supported by perisomatic-innervating GABAergic interneurons. We performed extracellular recordings of iden... | [
[
"22986407",
"How a common variant in the growth factor receptor gene, NTRK1, affects white matter.",
"Growth factors and their receptors are important for cellular migration as well as axonal guidance and myelination in the brain. They also play a key role in programmed cell death, and are implicated ... |
23226198 | Formal comparison of dual-parameter temporal discounting models in controls and pathological gamblers. | Temporal or delay discounting refers to the phenomenon that the value of a reward is discounted as a function of time to delivery. A range of models have been proposed that approximate the shape of the discount curve describing the relationship between subjective value and time. Recent evidence suggests that more than ... | [
[
"12951145",
"Structure and function of the vomeronasal system: an update.",
"Several developments during the past 15 years have profoundly affected our understanding of the vomeronasal system (VNS) of vertebrates. In the mid 1990s, the vomeronasal epithelium of mammals was found to contain two populat... | [
[
"23195123",
"Text-mining and neuroscience.",
"The wealth and diversity of neuroscience research are inherent characteristics of the discipline that can give rise to some complications. As the field continues to expand, we generate a great deal of data about all aspects, and from multiple perspectives,... |
22960226 | Empiricists are from Venus, modelers are from Mars: Reconciling experimental and computational approaches in cognitive neuroscience. | We describe how computational models can be useful to cognitive and behavioral neuroscience, and discuss some guidelines for deciding whether a model is useful. We emphasize that because instantiating a cognitive theory as a computational model requires specification of an explicit mechanism for the function in questio... | [
[
"19120115",
"Chronic stress, combined with a high-fat/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome.",
"In response to stress, some people lose while others gain weight. This is believed to be due to either increased beta-adrenergic... | [
[
"23476081",
"Framing Nicotine Addiction as a \"Disease of the Brain\": Social and Ethical Consequences.",
"In this article, we seek to better understand how a genomic vision of addiction may influence drug prevention and treatment. Though <i We explore the emerging view of addiction as a \"disease of ... |
23267340 | Social working memory: neurocognitive networks and directions for future research. | Navigating the social world requires the ability to maintain and manipulate information about people's beliefs, traits, and mental states. We characterize this capacity as social working memory (SWM). To date, very little research has explored this phenomenon, in part because of the assumption that general working memo... | [
[
"16482083",
"Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats.",
"Development of new antipsychotics and their novel applications may be facilitated through the use of physiological markers in clinically normal individuals. Both genetic and neurochemical evidence sugg... | [
[
"22922354",
"Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling.",
"Previous studies have shown that the intracellular domains of opioid receptors serve as platforms for the formation of a ... |
19654141 | Neuroanthropology: a humanistic science for the study of the culture-brain nexus. | In this article, we argue that a combined anthropology/neuroscience field of enquiry can make a significant and distinctive contribution to the study of the relationship between culture and the brain. This field, which can appropriately be termed as neuroanthropology, is conceived of as being complementary to and mutua... | [
[
"19400719",
"The science of neural interface systems.",
"The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of n... | [
[
"25205899",
"Neuroepidemiology of epilepsy in northwest India.",
"Epilepsy has a complex etiology characterised by recurring seizures.</AbstractText To study clinical profile of epilepsy patients with reference to type of epilepsy in northwest India. No previous Indian study has reported relative inci... |
19943188 | Fast Kalman filtering on quasilinear dendritic trees. | Optimal filtering of noisy voltage signals on dendritic trees is a key problem in computational cellular neuroscience. However, the state variable in this problem-the vector of voltages at every compartment-is very high-dimensional: realistic multicompartmental models often have on the order of N = 10(4) compartments. ... | [
[
"11222789",
"Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England.",
"To identify the frequency and characterize the phenotype of paraplegin mutations in the hereditary spastic paraparesis (HSP) population in the northeast of England.</AbstractText HSP is a d... | [
[
"20826300",
"Neuroscience and education: an ideal partnership for producing evidence-based solutions to Guide 21(st) Century Learning.",
"Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better u... |
23365838 | Simultaneous ODF estimation and tractography in HARDI. | We consider the problem of tracking white matter fibers in high angular resolution diffusion imaging (HARDI) data while simultaneously estimating the local fiber orientation profile. Prior work showed that an unscented Kalman filter (UKF) can be used for this problem, yet existing algorithms employ parametric mixture m... | [
[
"15831717",
"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.",
"Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and th... | [
[
"23542825",
"Neuroanatomy of Cornudescoides kulkarnii n. sp., a gill parasite of Mystus vittatus in Meerut (UP), India.",
"Chemical named 5-bromo indoxyl acetate has been used to describe the nervous system of a viviparous monogenean Cornudescoides Kulkarni (1969), a gill parasite of Mystus vittatus. ... |
23926462 | Neurogenetics and Nutrigenomics of Neuro-Nutrient Therapy for Reward Deficiency Syndrome (RDS): Clinical Ramifications as a Function of Molecular Neurobiological Mechanisms. | In accord with the new definition of addiction published by American Society of Addiction Medicine (ASAM) it is well-known that individuals who present to a treatment center involved in chemical dependency or other documented reward dependence behaviors have impaired brain reward circuitry. They have hypodopaminergic f... | [
[
"15663891",
"Orexin A promotes histamine, but not norepinephrine or serotonin, release in frontal cortex of mice.",
"To investigate the effects of orexin A on release of histamine, norepinephrine, and serotonin in the frontal cortex of mice.</AbstractText Samples for measuring histamine, norepinephrin... | [
[
"23060781",
"Using \"smart stimulators\" to treat Parkinson's disease: re-engineering neurostimulation devices.",
"Let's imagine the cruise control of your car locked at 120 km/h on any road in any condition (city, country, highway, sunny or rainy weather), or your car air conditioner set on ma... |
22639700 | Mitochondrial DNA: A Blind Spot in Neuroepigenetics. | Neuroepigenetics, which includes nuclear DNA modifications such as 5-methylcytosine and 5-hydoxymethylcytosine and modifications of nuclear proteins such as histones, is emerging as the leading field in molecular neuroscience. Historically, a functional role for epigenetic mechanisms, including in neuroepigenetics, has... | [
[
"8490989",
"Epidemiology of epilepsy in developing countries.",
"Epilepsy is an important health problem in developing countries, where its prevalence can be up to 57 per 1000 population. This article reviews the epidemiology of epilepsy in developing countries in terms of its incidence, prevalence, s... | [
[
"23366028",
"Transcranial direct current stimulation in pediatric brain: a computational modeling study.",
"Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation which uses weak electric currents applied on the scalp to modulate activity of underlying brain tissu... |
23366028 | Transcranial direct current stimulation in pediatric brain: a computational modeling study. | Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation which uses weak electric currents applied on the scalp to modulate activity of underlying brain tissue. In addition to being used as a tool for cognitive neuroscience investigations, tDCS has generated considerable interest for... | [
[
"12721816",
"Dopamine D3 receptor gene polymorphism and violent behavior: relation to impulsiveness and ADHD-related psychopathology.",
"Several lines of evidence indicate that dopaminergic neurotransmission is involved in the regulation of impulsive aggression and violence and that genetically determ... | [
[
"23202064",
"Three-dimensional multiwaveguide probe array for light delivery to distributed brain circuits.",
"To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive... |
23504543 | Bio-amplifier with Driven Shield Inputs to Reduce Electrical Noise and its Application to Laboratory Teaching of Electrophysiology. | We describe a custom-designed bio-amplifier and its use in teaching neurophysiology to undergraduate students. The amplifier has the following features: 1) differential amplification with driven shield inputs, which makes it workable even in electrically unshielded environments, 2) high input impedance to allow recordi... | [
[
"21386006",
"Optogenetics in the teaching laboratory: using channelrhodopsin-2 to study the neural basis of behavior and synaptic physiology in Drosophila.",
"Here we incorporate recent advances in Drosophila neurogenetics and \"optogenetics\" into neuroscience laboratory exercises. We used the light-... | [
[
"22958820",
"How variable clones build an invariant retina.",
"A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-trac... |
22557965 | An ontological approach to describing neurons and their relationships. | The advancement of neuroscience, perhaps one of the most information rich disciplines of all the life sciences, requires basic frameworks for organizing the vast amounts of data generated by the research community to promote novel insights and integrated understanding. Since Cajal, the neuron remains a fundamental unit... | [
[
"17049754",
"Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers.",
"To examine the relationship between impulsivity and smoking cessation treatment response among adolescents.</AbstractText Thirty adolescent smokers participated in a high school bas... | [
[
"23130007",
"When Do We Confuse Self and Other in Action Memory? Reduced False Memories of Self-Performance after Observing Actions by an Out-Group vs. In-Group Actor.",
"Observing another person performing an action can lead to a false memory of having performed the action oneself - the observation-i... |
23504612 | An undergraduate laboratory exercise examining the psychomotor stimulant effects of caffeine in laboratory rats. | This paper describes an exercise in a Systems and Behavioral Neuroscience with Laboratory class, an introductory laboratory class taken by Barnard College students majoring in a wide range of academic topics. The study took place over three weeks, allowing students to assess the effects of caffeine on motor stimulation... | [
[
"17940025",
"Short-term meditation training improves attention and self-regulation.",
"Recent studies suggest that months to years of intensive and systematic meditation training can improve attention. However, the lengthy training required has made it difficult to use random assignment of participant... | [
[
"22925211",
"Developmental neurotoxicity testing: scientific approaches towards the next generation to protect the developing nervous system of children. An overview of the Developmental Neurotoxicity Symposium in 2011.",
"The Developmental Neurotoxicology (DNT) Committee has been working to promote d... |
22977368 | Coping with Brain Disorders using Neurotechnology. | Brain disorders account for more than 34% of the global burden of disease, crippling nations by decreasing their "mental capital"-with greater effect in developing countries. Early detection is the key to their management, but establishing such programmes seems nearly impossible due to the high prevalence of the dysfun... | [
[
"12716950",
"Hierarchical processing in spoken language comprehension.",
"Understanding spoken language requires a complex series of processing stages to translate speech sounds into meaning. In this study, we use functional magnetic resonance imaging to explore the brain regions that are involved in ... | [
[
"23110153",
"Prediction of muscle activities from electrocorticograms in primary motor cortex of primates.",
"Electrocorticography (ECoG) has drawn attention as an effective recording approach for brain-machine interfaces (BMI). Previous studies have succeeded in classifying movement intention and pre... |
23420996 | The fundamental role of morphology in experimental neurotoxicology: the example of chemotherapy-induced peripheral neurotoxicity. | The peripheral nervous system is a frequent target of toxic agents. The accurate identification of the sites of neurotoxic action through the morphological characterization of reliable in vivo models or in vitro systems can give fundamental clues when investigating the pathogenesis and interpreting the clinical feature... | [
[
"22430310",
"Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish.",
"The tachykinins are a family of neuropeptides, including substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), that are encoded by the tac1 (SP and NKA) or tac2/3 (NKB) gene... | [
[
"23010511",
"Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation.",
"One of the key aspects of neuronal differentiation is the array of neurotransmitters and neurotransmitter receptors that each neuron possesse... |
23142960 | Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders. | Neuromyelitis optica (NMO) has been described as a disease clinically characterised by severe optic neuritis (ON) and transverse myelitis (TM). Other features of NMO include female preponderance, longitudinally extensive spinal cord lesions (>3 vertebral segments), and absence of oligoclonal IgG bands . In spite of ... | [
[
"22304908",
"Immune cells exploit a neural circuit to enter the CNS.",
"Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location... | [
[
"23010509",
"Using mouse models of autism spectrum disorders to study the neurotoxicology of gene-environment interactions.",
"To better study the role of genetics in autism, mouse models have been developed which mimic the genetics of specific autism spectrum and related disorders. These models have ... |
20797539 | Spatiotemporal response properties of optic-flow processing neurons. | A central goal in sensory neuroscience is to fully characterize a neuron's input-output relation. However, strong nonlinearities in the responses of sensory neurons have made it difficult to develop models that generalize to arbitrary stimuli. Typically, the standard linear-nonlinear models break down when neurons exhi... | [
[
"11253062",
"Association study designs for complex diseases.",
"Assessing the association between DNA variants and disease has been used widely to identify regions of the genome and candidate genes that contribute to disease. However, there are numerous examples of associations that cannot be replicat... | [
[
"22958820",
"How variable clones build an invariant retina.",
"A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-trac... |
22958820 | How variable clones build an invariant retina. | A fundamental question in developmental neuroscience is how a collection of progenitor cells proliferates and differentiates to create a brain of the appropriate size and cellular composition. To address this issue, we devised lineage-tracing assays in developing zebrafish embryos to reconstruct entire retinal lineage ... | [
[
"9222381",
"Molecular mimicry between HIV-1 gp41 and an astrocyte isoform of alpha-actinin.",
"A 100-kDa astrocyte antigen previously shown to cross-react with a monoclonal antibody (MAb) generated against amino acids (aa) 598 to 609 of the transmembrane protein gp41 of human immunodeficiency virus ty... | [
[
"23227112",
"A Social Neuroscience Perspective on Stress and Health.",
"Psychological stress is a major risk factor for the development and progression of a number of diseases, including cardiovascular disease, cancer, arthritis, and major depression. A growing body of research suggests that long-term... |
21345429 | Challenging the supremacy of the frontal lobe: early views (1906-1909) of Christfried Jakob on the human cerebral cortex. | This article focuses on a series of six studies that address functional localization in the frontal lobe; they were published in Argentina between 1906 and 1909 by Christfried Jakob (1866-1956), one of the great thinkers in early 20th century neuropathology and neurophilosophy. At that time, the localization-holism con... | [
[
"21896369",
"The size and burden of mental disorders and other disorders of the brain in Europe 2010.",
"To provide 12-month prevalence and disability burden estimates of a broad range of mental and neurological disorders in the European Union (EU) and to compare these findings to previous estimates. ... | [
[
"23110153",
"Prediction of muscle activities from electrocorticograms in primary motor cortex of primates.",
"Electrocorticography (ECoG) has drawn attention as an effective recording approach for brain-machine interfaces (BMI). Previous studies have succeeded in classifying movement intention and pre... |
23428079 | Capturing specific abilities as a window into human individuality: the example of face recognition. | Proper characterization of each individual's unique pattern of strengths and weaknesses requires good measures of diverse abilities. Here, we advocate combining our growing understanding of neural and cognitive mechanisms with modern psychometric methods in a renewed effort to capture human individuality through a cons... | [
[
"15831717",
"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.",
"Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and th... | [
[
"22946114",
"Giuseppe Ferrario and the epidemiology of apoplexy during the 19th century.",
"To analyze the pioneering research of Giuseppe Ferrario (1802-1870) on the epidemiology of apoplexy. To our knowledge, his work might have been the first to systematically investigate the epidemiology of cerebr... |
22483076 | Isolating N400 as neural marker of vocal anger processing in 6-11-year old children. | Vocal anger is a salient social signal serving adaptive functions in typical child development. Despite recent advances in the developmental neuroscience of emotion processing with regard to visual stimuli, little remains known about the neural correlates of vocal anger processing in childhood. This study represents th... | [
[
"2687720",
"Two-stage model of memory trace formation: a role for \"noisy\" brain states.",
"Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during differe... | [
[
"23493834",
"Teaching neuroinformatics with an emphasis on quantitative locus analysis.",
"Although powerful bioinformatics tools are available for free on the web and are used by neuroscience professionals on a daily basis, neuroscience students are largely ignorant of them. This Neuroinformatics mod... |
23671950 | Effect of head circumference on parameters of pattern reversal visual evoked potential in healthy adults of central India. | Visual evoked response testing has been one of the most exciting clinical tools to be developed from neurophysiologic research in recent years and has provided us with an objective method of identifying abnormalities of the afferent visual pathways. Investigation were carried out to see whether the head circumference i... | [
[
"15371227",
"Specific non-coplanar PCB-mediated modulation of bottlenose dolphin and beluga whale phagocytosis upon in vitro exposure.",
"Contaminant-induced immunosuppression by organochlorines (OC), particularly polychlorinated biphenyls (PCBs), has been suspected as a cofactor in the deaths of thou... | [
[
"22307590",
"Functional profiling of neurons through cellular neuropharmacology.",
"We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this study, dissociated dorsal-root ga... |
23218585 | Myasthenia gravis in the elderly. | The objective of the study is to examine clinical, therapeutic and prognostic factors of myasthenia gravis (MG) in the elderly.</AbstractText We reviewed all MG files of patients who attended the neuro-immunology clinic at Rabin Medical Center, Petah Tikva, Israel from January 1995 until September 2011 for demographic ... | [
[
"20012068",
"Astrocytes: biology and pathology.",
"Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insult... | [
[
"22367250",
"A 3-dimensional digital atlas of the ascending sensory and the descending motor systems in the pigeon brain.",
"Pigeons are classic animal models for learning, memory, and cognition. The majority of the current understanding about avian neurobiology outside of the domain of the song syste... |
23262400 | Low-dose adolescent nicotine and methylphenidate have additive effects on adult behavior and neurochemistry. | Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) have higher rates of smoking than adolescents without ADHD. Since methylphenidate is the primary drug used to treat ADHD, it is likely that many adolescents are exposed to both methylphenidate and nicotine. Recent studies have established that adolescent ... | [
[
"12584340",
"Tat-neutralizing antibodies in vaccinated macaques.",
"The human immunodeficiency virus Tat protein is essential for virus replication and is a candidate vaccine antigen. Macaques immunized with Tat or chemically modified Tat toxoid having the same clade B sequence developed strong antibo... | [
[
"23092761",
"Dreaming of mathematical neuroscience for half a century.",
"Theoreticians have been enchanted by the secrets of the brain for many years: how and why does it work so well? There has been a long history of searching for its mechanisms. Theoretical or even mathematical scientists have prop... |
23730254 | Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes. | Nitric oxide (NO) is a versatile cellular messenger performing a variety of physiologic and pathologic actions in most tissues. It is particularly important in the nervous system, where it is involved in multiple functions, as well as in neuropathology, when produced in excess. Several of these functions are based on i... | [
[
"10210626",
"P300 and response time from a manual Stroop task.",
"Manual response time (RT) and P300 event-related potential (ERP) measures were recorded in a Stroop color naming task to determine if previous results with vocal responses would be obtained using an arbitrary stimulus-response (S-R) map... | [
[
"23493834",
"Teaching neuroinformatics with an emphasis on quantitative locus analysis.",
"Although powerful bioinformatics tools are available for free on the web and are used by neuroscience professionals on a daily basis, neuroscience students are largely ignorant of them. This Neuroinformatics mod... |
22373615 | Perspective: Upcoming paradigm shifts for psychiatry in clinical care, research, and education. | Psychiatry is facing a crisis fueled by a fragmented and inefficient system of care delivery and a disconnection between the state of research and the state of psychiatry education and practice. Many factors contribute to the current state of psychiatric care. Psychiatry is a shortage specialty, and this will become wo... | [
[
"11330208",
"Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats.",
"Recent work indicates that the orexin/hypocretin-containing neurons of the lateral hypothalamus are involved in control of REM sleep phenomena, but site-specific actions in control... | [
[
"22305544",
"[Methodology of neuroepidemiological studies in tropical countries: a challenge?].",
"The purpose of this paper is to highlight the difficulties of applying neuroepidemiological methods in low income countries or developing countries, which are mostly tropical countries, taking advantage ... |
22155385 | Metabotropic glutamate receptor 1 (mGluR1): antibody specificity and receptor expression in cultured primary neurons. | The availability of high quality, well-characterized antibodies for molecular and cellular neuroscience studies is important. However, not all available antibodies are rigorously evaluated, nor are limitations of particular antibodies often reported. We have examined a panel of currently available mGluR1 antibodies and... | [
[
"15996748",
"Correlates of trait impulsiveness in performance measures and neuropsychological tests.",
"Performance measures of impulsiveness offer great promise for assessing this trait in clinical and experimental studies. However, little is known about their relative superiority or inferiority to s... | [
[
"22431838",
"The brighter side of music in dystonia.",
"To report a patient with genetically proven DYT1 dystonia who shows dramatic improvement in symptoms while playing the piano.</AbstractText Case study.</AbstractText Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Ne... |
23053864 | Estimating summary statistics in the spike-train space. | Estimating sample averages and sample variability is important in analyzing neural spike trains data in computational neuroscience. Current approaches have focused on advancing the use of parametric or semiparametric probability models of the underlying stochastic process, where the probabilistic distribution is charac... | [
[
"21391760",
"The default network distinguishes construals of proximal versus distal events.",
"Humans enjoy a singular capacity to imagine events that differ from the \"here-and-now.\" Recent cognitive neuroscience research has linked such simulation processes to the brain's \"default network.\" Howev... | [
[
"23218585",
"Myasthenia gravis in the elderly.",
"The objective of the study is to examine clinical, therapeutic and prognostic factors of myasthenia gravis (MG) in the elderly.</AbstractText We reviewed all MG files of patients who attended the neuro-immunology clinic at Rabin Medical Center, Petah T... |
23316177 | Affective neuronal selection: the nature of the primordial emotion systems. | Based on studies in affective neuroscience and evolutionary psychiatry, a tentative new proposal is made here as to the nature and identification of primordial emotional systems. Our model stresses phylogenetic origins of emotional systems, which we believe is necessary for a full understanding of the functions of emot... | [
[
"11144366",
"Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events.",
"Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was... | [
[
"22328183",
"Towards a closed-loop cochlear implant system: application of embedded monitoring of peripheral and central neural activity.",
"Although the cochlear implant (CI) is widely considered the most successful neural prosthesis, it is essentially an open-loop system that requires extensive init... |
30123682 | Neurotoxicology: Five new things. | Neurotoxic disease can mimic many common neurologic disease states, including parkinsonism, myelopathy, neuropathy, and encephalopathy. Accurate diagnosis and appropriate treatment may result in a favorable outcome. This review highlights 5 areas of neurotoxicology for which there is an emerging understanding of diseas... | [
[
"15050709",
"Tactile discrimination activates the visual cortex of the recently blind naive to Braille: a functional magnetic resonance imaging study in humans.",
"The occipital cortex of blind subjects is known to be activated during tactile discrimination tasks such as Braille reading. To investigat... | [
[
"22963990",
"Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichment.",
"Aberrant repetitive behaviors are commonly observed in a variety of neurodevelopmental, neurological, and neuropsychiatric disorders. Little is known about the... |
23206683 | Optogenetic neuromodulation. | The recent development of optogenetics, a revolutionary research tool in neuroscience, portends an evolution of current clinical neuromodulation tools. A form of gene therapy, optogenetics makes possible highly precise spatial and temporal control of specific neuronal populations. This technique has already provided se... | [
[
"20800054",
"Kisspeptins: bridging energy homeostasis and reproduction.",
"Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive diso... | [
[
"23029114",
"Monitoring performance degradation of cerebellar functions using computational neuroscience methods: implications on neurological diseases.",
"Neurodegeneration is a major cause of human disease. Within the cerebellum, neuronal degeneration and/or dysfunction has been associated with many... |
22431838 | The brighter side of music in dystonia. | To report a patient with genetically proven DYT1 dystonia who shows dramatic improvement in symptoms while playing the piano.</AbstractText Case study.</AbstractText Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, England.</AbstractText A 49-year-old r... | [
[
"21723668",
"Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.",
"Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental condition characterised by inattention, impulsivity and hyperactivity; it is frequently co-morbid... | [
[
"21861199",
"Optimal experimental design for sampling voltage on dendritic trees in the low-SNR regime.",
"Due to the limitations of current voltage sensing techniques, optimal filtering of noisy, undersampled voltage signals on dendritic trees is a key problem in computational cellular neuroscience. ... |
20425240 | Advances in pediatric neurovirology. | Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been associated with chronic encephalopathy, encephalitis, demyelinating diseas... | [
[
"21325527",
"Emergence of learned categorical representations within an auditory forebrain circuit.",
"Many learned behaviors are thought to require the activity of high-level neurons that represent categories of complex signals, such as familiar faces or native speech sounds. How these complex, exper... | [
[
"20797539",
"Spatiotemporal response properties of optic-flow processing neurons.",
"A central goal in sensory neuroscience is to fully characterize a neuron's input-output relation. However, strong nonlinearities in the responses of sensory neurons have made it difficult to develop models that genera... |
23231650 | Dissociable brain signatures of choice conflict and immediate reward preferences in alcohol use disorders. | Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited. ... | [
[
"19005051",
"Light-induced rescue of breathing after spinal cord injury.",
"Paralysis is a major consequence of spinal cord injury (SCI). After cervical SCI, respiratory deficits can result through interruption of descending presynaptic inputs to respiratory motor neurons in the spinal cord. Expressio... | [
[
"25103077",
"Clinical and electrophysiologic features of childhood Guillain-Barré syndrome in Northeast China.",
"Since little has been reported in previous studies, we aimed to find the clinical and electrophysiologic characteristics associated with childhood Guillain-Barré Syndrome (GBS) in Nor... |
20530254 | Sensitivity and selectivity of neurons in auditory cortex to the pitch, timbre, and location of sounds. | We are able to rapidly recognize and localize the many sounds in our environment. We can describe any of these sounds in terms of various independent "features" such as their loudness, pitch, or position in space. However, we still know surprisingly little about how neurons in the auditory brain, specifically the audit... | [
[
"3316677",
"Psychoneuroimmunology: interactions between central nervous system and immune system.",
"Psychoneuroimmunology, a rapidly developing field, has to do with the complex bidirectional interactions between the central nervous system and the immune system. Neuroendocrine influences modulate imm... | [
[
"20953339",
"Sign Languages: Contribution to Neurolinguistics from Cross-Modal Research.",
"Using sign language research as an example, we argue that both the cross-linguistic descriptive approach to data, advocated by Evans and Levinson (2009), as well as abstract ('formal') analyses are necessary st... |
23210812 | Researchers and the translational reality. Interview with Karen Aboody. | Karen Aboody has first-hand experience of taking a potential therapy from the laboratory into clinical trials. Here, she shares with us the challenges and rewards of going from bench to bedside, and why all biomedical researchers need to know what it takes to make the transition if they want the best chance of seeing t... | [
[
"3272153",
"Cellular determination in the Xenopus retina is independent of lineage and birth date.",
"Xenopus embryos injected with tritiated thymidine throughout the stages of embryonic retinal neurogenesis showed that more than 95% of the embryonic retinal cells are born within a 25 hr period. While... | [
[
"22936912",
"Decoding semantics across fMRI sessions with different stimulus modalities: a practical MVPA study.",
"Both embodied and symbolic accounts of conceptual organization would predict partial sharing and partial differentiation between the neural activations seen for concepts activated via di... |
23269439 | The p.Ala510Val mutation in the SPG7 (paraplegin) gene is the most common mutation causing adult onset neurogenetic disease in patients of British ancestry. | The c.1529C >T change in the SPG7 gene, encoding the mutant p.Ala510Val paraplegin protein, was first described as a polymorphism in 1998. This was based on its frequency of 3 % and 4 % in two separate surveys of controls in the United Kingdom (UK) population. Subsequently, it has been found to co-segregate with dis... | [
[
"9892252",
"A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia.",
"In a preliminary dose-finding study, D-cycloserine, a partial agonist at the glycine modulatory site of the glutamatergic N-methyl-D-aspartate (NMDA) receptor, improved negativ... | [
[
"22998948",
"Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis--2012 Curt Richter Award Winner.",
"Low birthweight, a marker of an adverse in utero environment, is associated with cardiometabolic disease and brain disorders in adulthood. The adaptive... |
23908850 | Cognitive decline and dementia in the oldest-old. | The oldest-old are the fastest growing segment of the Western population. Over half of the oldest-old will have dementia, but the etiology is yet unknown. Age is the only risk factor consistently associated with dementia in the oldest-old. Many of the risk and protective factors for dementia in the young elderly, such ... | [
[
"22708717",
"No evidence of intelligence improvement after working memory training: a randomized, placebo-controlled study.",
"Numerous recent studies seem to provide evidence for the general intellectual benefits of working memory training. In reviews of the training literature, Shipstead, Redick, an... | [
[
"23181011",
"Neuronal function is necessary but not sufficient for consciousness: consciousness is necessary for will.",
"Behavioral neuroscience has presented philosophers with the task of clarifying the relationship between neural determinism and free will. If neural functions encode information and... |
23261499 | Neurochemical profiles of some novel psychoactive substances. | Fourteen substances from the class of drugs sometimes known as "legal highs" were screened against a battery of human receptors in binding assays, and their potencies as inhibitors of monoamine uptake determined in functional in vitro assays. Thirteen of the test substances acted as inhibitors of monoamine uptake at su... | [
[
"18773078",
"Spleen vagal denervation inhibits the production of antibodies to circulating antigens.",
"Recently the vagal output of the central nervous system has been shown to suppress the innate immune defense to pathogens. Here we investigated by anatomical and physiological techniques the communi... | [
[
"23200550",
"Next generation sequencing for neurological diseases: new hope or new hype?",
"Over the past year huge advances have been made in our ability to determine the genetic aetiology of many neurological diseases through the utilisation of next generation sequencing platforms. This technology i... |
23226123 | Identifying temporal and causal contributions of neural processes underlying the Implicit Association Test (IAT). | The Implicit Association Test (IAT) is a popular behavioral measure that assesses the associative strength between outgroup members and stereotypical and counterstereotypical traits. Less is known, however, about the degree to which the IAT reflects automatic processing. Two studies examined automatic processing contri... | [
[
"17691351",
"An introduction to operative neuromodulation and functional neuroprosthetics, the new frontiers of clinical neuroscience and biotechnology.",
"Operative neuromodulation is the field of altering electrically or chemically the signal transmission in the nervous system by implanted devices i... | [
[
"23286166",
"Group-wise consistent fiber clustering based on multimodal connectional and functional profiles.",
"Fiber clustering is an essential step towards brain connectivity modeling and tract-based analysis of white matter integrity via diffusion tensor imaging (DTI) in many clinical neuroscience... |
22794533 | Infusing developmental neuroscience into school-based preventive interventions: implications and future directions. | Recent advances in developmental neuroscience have the potential to significantly impact the behavioral and academic outcomes of adolescents. By adopting a translational approach, we aim to promote the transfer of knowledge related to neurological, cognitive, and emotion regulatory factors that underlie youth's ability... | [
[
"19874855",
"Species differences in group size and electrosensory interference in weakly electric fishes: implications for electrosensory processing.",
"In animals with active sensory systems, group size can have dramatic effects on the sensory information available to individuals. In \"wave-type\" we... | [
[
"23439731",
"Cerebellar pathology of a dual clinical diagnosis: patients with essential tremor and dystonia.",
"Clinical studies have implicated the cerebellum in the pathogenesis of essential tremor (ET), and recent postmortem studies have identified structural changes in the ET cerebellum. While the... |
23366259 | Design of the multi-channel electroencephalography-based brain-computer interface with novel dry sensors. | The traditional brain-computer interface (BCI) system measures the electroencephalography (EEG) signals by the wet sensors with the conductive gel and skin preparation processes. To overcome the limitations of traditional BCI system with conventional wet sensors, a wireless and wearable multi-channel EEG-based BCI syst... | [
[
"19064491",
"Retention of high tactile acuity throughout the life span in blindness.",
"Previous studies of tactile acuity on the fingertip, using passive touch, have demonstrated an age-related decline in spatial resolution for both sighted and blind subjects. We have reexamined this age dependence w... | [
[
"23060781",
"Using \"smart stimulators\" to treat Parkinson's disease: re-engineering neurostimulation devices.",
"Let's imagine the cruise control of your car locked at 120 km/h on any road in any condition (city, country, highway, sunny or rainy weather), or your car air conditioner set on ma... |
21840408 | Modulating the brain at work using noninvasive transcranial stimulation. | This paper proposes a shift in the way researchers currently view and use transcranial brain stimulation technologies. From a neuroscience perspective, the standard application of both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) has been mainly to explore the function of v... | [
[
"19298949",
"Perceptual simulation in conceptual combination: evidence from property generation.",
"In three experiments, participants received nouns or noun phrases for objects and verbally generated their properties (\"feature listing\"). Several sources of evidence indicated that participants const... | [
[
"23029114",
"Monitoring performance degradation of cerebellar functions using computational neuroscience methods: implications on neurological diseases.",
"Neurodegeneration is a major cause of human disease. Within the cerebellum, neuronal degeneration and/or dysfunction has been associated with many... |
22969712 | Neural systems supporting cognitive-affective interactions in adolescence: the role of puberty and implications for affective disorders. | Evidence from longitudinal studies suggests that adolescence may represent a period of vulnerability that, in the context of adverse events, could contribute to developmental trajectories toward behavioral and emotional health problems, including affective disorders. Adolescence is also a sensitive period for the devel... | [
[
"21677369",
"A cortical neural prosthesis for restoring and enhancing memory.",
"A primary objective in developing a neural prosthesis is to replace neural circuitry in the brain that no longer functions appropriately. Such a goal requires artificial reconstruction of neuron-to-neuron connections in a... | [
[
"22344946",
"Answering the big questions in neuroscience: DoD's experimental research wing takes on massive, high-risk projects.",
"When the Defense Advanced Research Projects Agency (DARPA) asks research questions, it goes big. This is, after all, the same agency that put together teams of scientists... |
23129998 | Supercomputers ready for use as discovery machines for neuroscience. | NEST is a widely used tool to simulate biological spiking neural networks. Here we explain the improvements, guided by a mathematical model of memory consumption, that enable us to exploit for the first time the computational power of the K supercomputer for neuroscience. Multi-threaded components for wiring and simula... | [
[
"21386006",
"Optogenetics in the teaching laboratory: using channelrhodopsin-2 to study the neural basis of behavior and synaptic physiology in Drosophila.",
"Here we incorporate recent advances in Drosophila neurogenetics and \"optogenetics\" into neuroscience laboratory exercises. We used the light-... | [
[
"23391878",
"The dialectical law between coronary artery disease and stroke recurrence.",
"In this issue of Neuroendocrinology Letters Kováčik et al. reported that coronary artery disease is not associated with stroke recurrence. Although the data were analyzed by statistical methods and th... |
22946114 | Giuseppe Ferrario and the epidemiology of apoplexy during the 19th century. | To analyze the pioneering research of Giuseppe Ferrario (1802-1870) on the epidemiology of apoplexy. To our knowledge, his work might have been the first to systematically investigate the epidemiology of cerebrovascular accidents, with the aim of shedding light on the underlying causes.</AbstractText A detailed analysi... | [
[
"19120115",
"Chronic stress, combined with a high-fat/high-sugar diet, shifts sympathetic signaling toward neuropeptide Y and leads to obesity and the metabolic syndrome.",
"In response to stress, some people lose while others gain weight. This is believed to be due to either increased beta-adrenergic... | [
[
"23383397",
"Interactions between oestrogen and the renin angiotensin system - potential mechanisms for gender differences in Alzheimer's disease.",
"Interactions between oestrogen and the renin angiotensin system (RAS) are reviewed and explored from the perspective where these interactions may modula... |
25205899 | Neuroepidemiology of epilepsy in northwest India. | Epilepsy has a complex etiology characterised by recurring seizures.</AbstractText To study clinical profile of epilepsy patients with reference to type of epilepsy in northwest India. No previous Indian study has reported relative incidence of various types of seizures with reference to type of epilepsy.</AbstractText... | [
[
"21466746",
"Study on the possible association of brain-derived neurotrophic factor polymorphism with the developmental course of symptoms of attention deficit and hyperactivity.",
"Several studies have, with conflicting results, investigated the relationship between the Val⁶⁶Met polymor... | [
[
"20425240",
"Advances in pediatric neurovirology.",
"Viral infections of the pediatric central nervous system (CNS) encompass a broad spectrum of both perinatally and postnatally acquired diseases with potentially devastating effects on the developing brain. In children, viral infections have been ass... |
22365959 | Defining the genetic architecture of human developmental language impairment. | Language is a uniquely human trait, which poses limitations on animal models for discovering biological substrates and pathways. Despite this challenge, rapidly developing biotechnology in the field of genomics has made human genetics studies a viable alternative route for defining the molecular neuroscience of human l... | [
[
"21893533",
"The multiple time scales of sleep dynamics as a challenge for modelling the sleeping brain.",
"A particular property of the sleeping brain is that it exhibits dynamics on very different time scales ranging from the typical sleep oscillations such as sleep spindles and slow waves that can ... | [
[
"23077800",
"Occupational exposure to styrene in the fibreglass reinforced plastic industry: comparison between two different manufacturing processes.",
"Styrene is used in manufacturing fiberglass reinforced plastics: and occupational exposure was related to neurotoxicology and genotoxicity. The sum ... |
37539014 | Quantification of Speech Disfluency as a Marker of Medication-Induced Cognitive Impairment: An Application of Computerized Speech Analysis in Neuropharmacology. | We present the results of a study investigating the use of speech and language characteristics extracted from spontaneous spoken discourse to assess changes in cognitive function. Specifically, we investigated the use of automatic speech recognition technology to characterize spontaneous speech disfluency induced by to... | [
[
"21748284",
"A failure to normalize biochemical and metabolic insults during morphine withdrawal disrupts synaptic repair in mice transgenic for HIV-gp120.",
"Drug abuse in HIV-infected individuals accelerates the onset and progression of HIV-associated neurocognitive disorders (HAND). Opiates are a c... | [
[
"23023166",
"The vagal innervation of the gut and immune homeostasis.",
"The central nervous system interacts dynamically with the immune system to modulate inflammation through humoral and neural pathways. Recently, in animal models of sepsis, the vagus nerve (VN) has been proposed to play a crucial ... |
23219683 | The effect of lead exposure on brain iron homeostasis and the expression of DMT1/FP1 in the brain in developing and aged rats. | The relation between lead (Pb) and iron (Fe) becomes increasingly concerned because they are both divalent metals that are absorbed by the same intestinal mechanism, and Pb exposure and Fe deficiency in the developmental brain, as well as Fe overload in the aged brain, can cause cognitive deficits. However, the interac... | [
[
"9526084",
"Category-specific semantic deficits in focal and widespread brain damage: a computational account.",
"Category-specific semantic impairments have been explained in terms of preferential damage to different types of features (e.g., perceptual vs. functional). This account is compatible with... | [
[
"37539014",
"Quantification of Speech Disfluency as a Marker of Medication-Induced Cognitive Impairment: An Application of Computerized Speech Analysis in Neuropharmacology.",
"We present the results of a study investigating the use of speech and language characteristics extracted from spontaneous spo... |
23730352 | Sleep, neuroengineering and dynamics. | Modeling of consciousness-related phenomena and neuroengineering are fields that are rapidly growing together. We review recent approaches and developments and point out some promising directions of future research: Understanding the dynamics of consciousness states and associated oscillations, pathological oscillation... | [
[
"20800054",
"Kisspeptins: bridging energy homeostasis and reproduction.",
"Body energy reserves and metabolic state are relevant modifiers of puberty onset and fertility; forms of metabolic stress ranging from persistent energy insufficiency to morbid obesity are frequently linked to reproductive diso... | [
[
"23166484",
"Functional connectivity and tuning curves in populations of simultaneously recorded neurons.",
"How interactions between neurons relate to tuned neural responses is a longstanding question in systems neuroscience. Here we use statistical modeling and simultaneous multi-electrode recording... |
23576843 | Possibilities offered by implantable miniaturized cuff-electrodes for insect neurophysiology. | Recent advances in microsystems technology led to a miniaturization of cuff-electrodes, which suggests these electrodes not just for long-term neuronal recordings in mammalians, but also in medium-sized insects. In this study we investigated the possibilities offered by cuff-electrodes for neuroethology using insects a... | [
[
"11222789",
"Paraplegin gene analysis in hereditary spastic paraparesis (HSP) pedigrees in northeast England.",
"To identify the frequency and characterize the phenotype of paraplegin mutations in the hereditary spastic paraparesis (HSP) population in the northeast of England.</AbstractText HSP is a d... | [
[
"23252730",
"The physiology of fish behaviour: a selective review of developments over the past 40 years(§).",
"During the past 40 years many new techniques have emerged that have been pivotal in furthering understanding of the physiology of fish behaviour. Behavioural studies have been enhanced by vi... |
23341313 | Absence of verbal recall or memory for symptom acquisition in fear and trauma exposure: a conceptual case for fear conditioning and learned nonuse in assessment and treatment. | Absence of memory or verbal recall for symptom acquisition in fear and trauma exposure, as well as absence of successful coping behavior for life events, is associated with a number of diagnoses, including traumatic brain injury, posttraumatic stress disorder, pain, and anxiety. The difficulty with diagnosis and treatm... | [
[
"21749991",
"Acetazolamide-responsive exercise-induced episodic ataxia associated with a novel homozygous DARS2 mutation.",
"Leukoencephalopathy with brain stem and spinal cord involvement and brain lactate elevation (LBSL) was recently shown to be caused by mutations in the DARS2 gene, encoding a mit... | [
[
"23176028",
"Iranians' contribution to world literature on neuroscience.",
"The purpose of this study is to analyse Iranian scientific publications in the neuroscience subfields by librarians and neuroscientists, using Science Citation Index Expanded (SCIE) via Web of Science data over the period, 200... |
20360360 | Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection. | Expression of green fluorescent protein (GFP), its more fluorescent mutant forms (e.g., EGFP [enhanced GFP]), or their fusion protein derivatives, affords a number of informative possibilities in cellular neuroscience. EGFP is a soluble protein and appears to be homogeneously distributed within the cytosol of neurons w... | [
[
"11377409",
"Double-blind naltrexone and placebo comparison study in the treatment of pathological gambling.",
"The authors' goal was to assess the efficacy and tolerability of naltrexone in the treatment of pathologic gambling disorder.</AbstractText Eighty-three subjects who met criteria for DSM-IV ... | [
[
"20976129",
"The picture of the linguistic brain: how sharp can it be? Reply to Fedorenko & Kanwisher.",
"What is the best way to learn how the brain analyzes linguistic input? Two popular methods have attempted to segregate and localize linguistic processes: analyses of language deficits subsequent t... |
20419352 | Blue moon neurovirology: the merits of studying rare CNS diseases of viral origin. | While measles virus (MV) continues to have a significant impact on human health, causing 150,000-200,000 deaths worldwide each year, the number of fatalities that can be attributed to MV-triggered central nervous system (CNS) diseases are on the order of a few hundred individuals annually (World Health Organization 200... | [
[
"942927",
"Morphine suppression of ethanol withdrawal in mice.",
"The acute administration of morphine, alcohol or dopamine results in a pronounced suppression of the convulsions produced by alcohol in mice. The suppressive action of morphine on alcohol withdrawal in the mouse apparently is not a prod... | [
[
"20826300",
"Neuroscience and education: an ideal partnership for producing evidence-based solutions to Guide 21(st) Century Learning.",
"Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better u... |
20739175 | Micro-scale and microfluidic devices for neurobiology. | The precise spatial and temporal control afforded by microfluidic devices make them uniquely suited as experimental tools for cellular neuroscience. Micro-structures have been developed to direct the placement of cells and small organisms within a device. Microfluidics can precisely define pharmacological microenvironm... | [
[
"20665248",
"Developmental changes in the expression of kisspeptin mRNA in rat hypothalamus.",
"Kisspeptin is a family of neuropeptides and the natural ligands of G protein-coupled receptor (GPR)-54. Kisspeptin/GPR-54 system is known to play a pivotal role in puberty onset and in the regulation of rep... | [
[
"20802854",
"Optical mapping of release properties in synapses.",
"Synapses are important functional units that determine how information flows through the brain. Understanding their biophysical properties and the molecules that underpin them is an important goal of cellular neuroscience. Thus, it is ... |
23666281 | [What can microscopy teach us on suicide?]. | The fine neuroanatomy of mood disorders and suicide is a relatively recent field of investigation. Together with neuroimaging, molecular biology and biochemistry, histological analyses of post-mortem brain regions implicated in mood regulation allow gaining a better understanding of the cellular and molecular mechanism... | [
[
"21312401",
"Functional brain imaging in schizophrenia: selected results and methods.",
"Functional brain imaging studies of patients with schizophrenia may be grouped into those that assume that the signs and symptoms of schizophrenia are due to disordered circuitry within a critical brain region and... | [
[
"22905274",
"Toxocariasis and epilepsy: systematic review and meta-analysis.",
"Human toxocariasis is a zoonotic infection caused by the larval stages of Toxocara canis (T. canis) and less frequently Toxocara cati (T. cati). A relationship between toxocariasis and epilepsy has been hypothesized. We co... |
23110153 | Prediction of muscle activities from electrocorticograms in primary motor cortex of primates. | Electrocorticography (ECoG) has drawn attention as an effective recording approach for brain-machine interfaces (BMI). Previous studies have succeeded in classifying movement intention and predicting hand trajectories from ECoG. Despite such successes, however, there still remains considerable work for the realization ... | [
[
"12716950",
"Hierarchical processing in spoken language comprehension.",
"Understanding spoken language requires a complex series of processing stages to translate speech sounds into meaning. In this study, we use functional magnetic resonance imaging to explore the brain regions that are involved in ... | [
[
"23237463",
"Interactions between tactile and proprioceptive representations in haptics.",
"Neuroprosthetic limbs, regardless of their sophisticated motor control, require sensory feedback to viably interact with the environment. Toward that aim, the authors examined interrelationships between tactile... |
23853342 | HermesD: A High-Rate Long-Range Wireless Transmission System for Simultaneous Multichannel Neural Recording Applications. | HermesD is a high-rate, low-power wireless transmission system to aid research in neural prosthetic systems for motor disabilities and basic motor neuroscience. It is the third generation of our "Hermes systems" aimed at recording and transmitting neural activity from brain-implanted electrode arrays. This system suppo... | [
[
"23493966",
"Exploring sensory neuroscience through experience and experiment.",
"Many phenomena that we take for granted are illusions - color and motion on a TV or computer monitor, for example, or the impression of space in a stereo music recording. Even the stable image that we perceive when looki... | [
[
"20377146",
"Saccadic peak velocity sensitivity to variations in mental workload.",
"For research and applications in the field of (neuro)ergonomics, it is of increasing importance to have reliable methods for measuring mental workload. In the present study we examined the hypothesis that saccadic eye... |
23494679 | Electroretinograms in Drosophila: a robust and genetically accessible electrophysiological system for the undergraduate laboratory. | Laboratory courses in neurophysiology fulfill a critical need for inquiry-based training in undergraduate programs in neuroscience and biology. These courses typically use classical electrophysiological preparations to explore the basic features of neuronal function. However, current neuroscience research also focuses ... | [
[
"19669582",
"Monitoring health implications of pesticide exposure in factory workers in Pakistan.",
"The study aimed to determine the hazardous health effects of pesticides exposure in the factory workers by measuring plasma cholinesterase (PChE), pesticides residues, and renal and hepatic biochemical... | [
[
"23671950",
"Effect of head circumference on parameters of pattern reversal visual evoked potential in healthy adults of central India.",
"Visual evoked response testing has been one of the most exciting clinical tools to be developed from neurophysiologic research in recent years and has provided us ... |
25419230 | Improving Executive Function and its Neurobiological Mechanisms through a Mindfulness-Based Intervention: Advances within the Field of Developmental Neuroscience. | Poor executive function (EF) has been associated with a host of short- and long-term problems across the lifespan, including elevated rates of attention deficit hyperactivity disorder, depression, drug abuse, and antisocial behavior. Mindfulness-based interventions that focus on increasing awareness of one's thoughts, ... | [
[
"23017085",
"The maps problem and the mapping problem: two challenges for a cognitive neuroscience of speech and language.",
"Research on the brain basis of speech and language faces theoretical and empirical challenges. Most current research, dominated by imaging, deficit-lesion, and electrophysiolog... | [
[
"23505339",
"Baby Steps to Superintelligence: Neuroprosthetics and Children.",
"Children surviving neural injuries face challenges not seen by their adult counterparts, namely that they experience neural injury before reaching neurodevelopmental maturity. Neural prostheses offer one possible path to r... |
23137683 | Behavioral neuroscience: learning to suckle with signature odor. | A new study in mice reveals that an apparently innate behavior, suckling, is triggered not by a classical pheromone but by the pup learning the complex signature odor of its mother.</AbstractText | [
[
"17947337",
"Word-finding difficulty: a clinical analysis of the progressive aphasias.",
"The patient with word-finding difficulty presents a common and challenging clinical problem. The complaint of 'word-finding difficulty' covers a wide range of clinical phenomena and may signify any of a number of... | [
[
"22284580",
"Christfried Jakob's late views (1930-1949) on the psychogenetic function of the cerebral cortex and its localization: culmination of the neurophilosophical thought of a keen brain observer.",
"This article follows the culmination of the scientific thought of the neurobiologist Christfried... |
23010511 | Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation. | One of the key aspects of neuronal differentiation is the array of neurotransmitters and neurotransmitter receptors that each neuron possesses. One important goal of developmental neuroscience is to understand how these differentiated properties are established during development. In this paper, we use fluorescence act... | [
[
"18457512",
"Timing, storage, and comparison of stimulus duration engage discrete anatomical components of a perceptual timing network.",
"The temporal discrimination paradigm requires subjects to compare the duration of a probe stimulus to that of a sample previously stored in working or long-term me... | [
[
"23355814",
"What is social about social perception research?",
"A growing consensus in social cognitive neuroscience holds that large portions of the primate visual brain are dedicated to the processing of social information, i.e., to those aspects of stimuli that are usually encountered in social in... |
22807662 | Coding conspecific identity and motion in the electric sense. | Interactions among animals can result in complex sensory signals containing a variety of socially relevant information, including the number, identity, and relative motion of conspecifics. How the spatiotemporal properties of such evolving naturalistic signals are encoded is a key question in sensory neuroscience. Here... | [
[
"21731699",
"Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.",
"Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the S... | [
[
"22922354",
"Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling.",
"Previous studies have shown that the intracellular domains of opioid receptors serve as platforms for the formation of a ... |
23161463 | Recent advances in clinical neurogenetics. | Herein, I review the main papers in neurogenetic research published in the Journal of Neurology over the last year.</AbstractText | [
[
"15050709",
"Tactile discrimination activates the visual cortex of the recently blind naive to Braille: a functional magnetic resonance imaging study in humans.",
"The occipital cortex of blind subjects is known to be activated during tactile discrimination tasks such as Braille reading. To investigat... | [
[
"23280856",
"Intrahippocampal infusion of the Ih blocker ZD7288 slows evoked theta rhythm and produces anxiolytic-like effects in the elevated plus maze.",
"Hippocampal theta rhythm has been associated with a number of behavioral processes, including learning and memory, spatial behavior, sensorimotor... |
22940423 | HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors. | Human immunodeficiency virus-1 (HIV)-associated neurocognitive disorder (HAND) is a neurodegenerative disease for which there is no available neuroprotective therapy. Viral proteins, such as Tat, have been implicated as agents of neurotoxicity via multiple mechanisms, including effects by directly binding to the NMDA r... | [
[
"17959477",
"Increasing the performance of cortically-controlled prostheses.",
"Neural prostheses have received considerable attention due to their potential to dramatically improve the quality of life of severely disabled patients. Cortically-controlled prostheses are able to translate neural activit... | [
[
"23273129",
"Phase synchronization of neuronal noise in mouse hippocampal epileptiform dynamics.",
"Organized brain activity is the result of dynamical, segregated neuronal signals that may be used to investigate synchronization effects using sophisticated neuroengineering techniques. Phase synchrony ... |
23183130 | Nanopsychiatry--the potential role of nanotechnologies in the future of psychiatry: a systematic review. | Nanomedicine is defined as the area using nanotechnology's concepts for the benefit of human beings' health and well being. In this article, we aimed to provide an overview of areas where nanotechnology is applied and how they could be extended to care for psychiatric illnesses. The main applications of nanotechnology ... | [
[
"17506923",
"Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder.",
"Although attention-deficit/hyperactivity disorder (ADHD) is thought to be an inhibitory disorder, the question remains of how specific the inhibitory deficit is in adults and whe... | [
[
"23161463",
"Recent advances in clinical neurogenetics.",
"Herein, I review the main papers in neurogenetic research published in the Journal of Neurology over the last year.</AbstractText"
]
] |
23303059 | Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study. | Functional neuroimaging studies have implicated dysregulation of prefrontal circuits in major depressive disorder (MDD), and these circuits are a viable target for predicting treatment outcomes. However, because of the heterogeneity of tasks and samples used in studies to date, it is unclear whether the central dysfunc... | [
[
"20012068",
"Astrocytes: biology and pathology.",
"Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insult... | [
[
"23955619",
"An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis).",
"We herein report an autopsy case of the Marburg variant of multiple sclerosis (MS). A 29-year-old woman developed acute and progressive neurological symptoms. A diagnosis of MS was suspected based ... |
22922354 | Selective interactions of spinophilin with the C-terminal domains of the δ- and μ-opioid receptors and G proteins differentially modulate opioid receptor signaling. | Previous studies have shown that the intracellular domains of opioid receptors serve as platforms for the formation of a multi-component signaling complex consisting of various interacting partners (Leontiadis et al., 2009, Cell Signal. 21, 1218-1228; Georganta et al., 2010, Neuropharmacology, 59(3), 139-148). In the p... | [
[
"21312401",
"Functional brain imaging in schizophrenia: selected results and methods.",
"Functional brain imaging studies of patients with schizophrenia may be grouped into those that assume that the signs and symptoms of schizophrenia are due to disordered circuitry within a critical brain region and... | [
[
"23055474",
"The Hodgkin-Huxley heritage: from channels to circuits.",
"The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computa... |
23504446 | Using equivalence-based instruction to increase efficiency in teaching neuroanatomy. | A goal of all instruction is to efficiently allocate time spent teaching -- balancing redundancy that enhances learning with redundancy that is irrelevant to increasing student understanding. Efficient allocation of time allows the instructor to present additional material and go into more detail about the information ... | [
[
"9626715",
"The role of defeat and entrapment (arrested flight) in depression: an exploration of an evolutionary view.",
"The social rank theory of psychopathology suggests that with the evolution of social hierarchies various psychobiological mechanisms became attuned to the success or failure in con... | [
[
"23248404",
"Neuroprotective activity of Stereospermum suaveolens DC against 6-OHDA induced Parkinson's disease model.",
"To evaluate the neuroprotective effect of Stereospermum suaveolens DC on 6-hydroxy dopamine induced Parkinson's disease model.</AbstractText The study was conducted on Sprague-Dawl... |
23371266 | [Funcion sparing surgery in uro-oncology: germ cell tumors of the testis]. | Surgery in germ cell tumors of the testis (TGT) may result in andrological disorders, both after orchiectomy and after retroperitoneal lymphadenectomy (RPLND). Bilateral orchiectomy suppresses both testicular functions: exocrine and endocrine. In selected cases with bilateral TGT (metachronous/synchronous), or in the c... | [
[
"8490989",
"Epidemiology of epilepsy in developing countries.",
"Epilepsy is an important health problem in developing countries, where its prevalence can be up to 57 per 1000 population. This article reviews the epidemiology of epilepsy in developing countries in terms of its incidence, prevalence, s... | [
[
"23476081",
"Framing Nicotine Addiction as a \"Disease of the Brain\": Social and Ethical Consequences.",
"In this article, we seek to better understand how a genomic vision of addiction may influence drug prevention and treatment. Though <i We explore the emerging view of addiction as a \"disease of ... |
23167712 | Affect-specific modulation of the N1m to shock-conditioned tones: magnetoencephalographic correlates. | Despite its fundamental relevance for representing the emotional world surrounding us, human affective neuroscience research has widely neglected the auditory system, at least in comparison to the visual domain. Here, we have investigated the spatiotemporal dynamics of human affective auditory processing using time-sen... | [
[
"17030182",
"The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model.",
"The recently proposed Inflammatory Reflex describes an interaction between the vagus nerve and peripheral macrophages, resulting in attenuation of proinflammatory cytokine releas... | [
[
"23245219",
"Ventral striatum activation to prosocial rewards predicts longitudinal declines in adolescent risk taking.",
"Adolescence is a period of intensified emotions and an increase in motivated behaviors and passions. Evidence from developmental neuroscience suggests that this heightened emotion... |
23095170 | High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research. | Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specific gene expr... | [
[
"20012068",
"Astrocytes: biology and pathology.",
"Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insult... | [
[
"22520647",
"European study of research and development in mobility technology for persons with disabilities.",
"\\In the fall of 2010, the National Science Foundation, the National Institutes of Health and the U.S. Veteran's Administration jointly supported a review of mobility technology in Europe. ... |
29913996 | The attenuation of pain behaviour and serum interleukin-6 concentration by nimesulide in a rat model of neuropathic pain. | Background Evidence for a role of immune system in hyperalgesic pain states is increasing. Recent work in neuroimmunology suggests that the immune system does more than simply perform its well known functions of recognizing and removing invading pathogens and tumors. Interest in neuroinflammation and neuroimmune activa... | [
[
"21391760",
"The default network distinguishes construals of proximal versus distal events.",
"Humans enjoy a singular capacity to imagine events that differ from the \"here-and-now.\" Recent cognitive neuroscience research has linked such simulation processes to the brain's \"default network.\" Howev... | [
[
"20817916",
"Neuroscience: viable applications in education?",
"As a relatively young science, neuroscience is still finding its feet in potential collaborations with other disciplines. One such discipline is education, with the field of neuroeducation being on the horizon since the 1960s. However, al... |
22905274 | Toxocariasis and epilepsy: systematic review and meta-analysis. | Human toxocariasis is a zoonotic infection caused by the larval stages of Toxocara canis (T. canis) and less frequently Toxocara cati (T. cati). A relationship between toxocariasis and epilepsy has been hypothesized. We conducted a systematic review and a meta-analysis of available data to evaluate the strength of asso... | [
[
"17322880",
"Mapping autism risk loci using genetic linkage and chromosomal rearrangements.",
"Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage ... | [
[
"23077800",
"Occupational exposure to styrene in the fibreglass reinforced plastic industry: comparison between two different manufacturing processes.",
"Styrene is used in manufacturing fiberglass reinforced plastics: and occupational exposure was related to neurotoxicology and genotoxicity. The sum ... |
22937517 | Optogenetics: a novel optical manipulation tool for medical investigation. | Optogenetics is a new and rapidly evolving gene and neuroengineering technology that allows optical control of specific populations of neurons without affecting other neurons in the brain at high temporal and spatial resolution. By heterologous expression of the light-sensitive membrane proteins, cell type-specific dep... | [
[
"18448316",
"A critical look at the embodied cognition hypothesis and a new proposal for grounding conceptual content.",
"Many studies have demonstrated that the sensory and motor systems are activated during conceptual processing. Such results have been interpreted as indicating that concepts, and im... | [
[
"21723668",
"Steroid sulfatase-deficient mice exhibit endophenotypes relevant to attention deficit hyperactivity disorder.",
"Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental condition characterised by inattention, impulsivity and hyperactivity; it is frequently co-morbid... |
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