Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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negative regulation of apoptotic process positive regulation of dendrite extension protein ubiquitination | cell body; cytoplasm | metal ion binding ubiquitin protein ligase activity | Rattus norvegicus | Cytoplasm Lipoprotein Metal-binding Myristate Phosphoprotein Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger | MGALTSRQHA | MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDCTHPEGYLFGENSDLNFLGNRPVSFPYAAPPPHEPVKTLRSLINIRKDTLRLVKCAEEVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVHYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHSDGTFCVKPLKQKQVWDGVTYLLQEDYGIENKSNTQDFKVAEDDVRDNSAECVVCLSDVRDTLILPCRHCASCNVHCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPSSFNPIISSQTSDSEEHSSSENIPAGYEVVSLLEALNGPLTSSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTLSPLDHLSDCNSQGLKLNKSLSKSISQNSSVLHEEEDERSCSESDTQLSQRLSAQHPEEGPDVTPESENLTLSSSGAVDQSSCTGTPLSSTISSPEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEAPPSPRAASRAPSEEEETPAESPDSNFAGLPAGEQDAEGNDIMEEEDRSPVQEDGQRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGTWQHDAAIINRHNTQRRRLSPSSLEDPEEDRPCVWDPLAV | negative regulation of apoptotic process positive regulation of dendrite extension protein ubiquitination cell body; cytoplasm metal ion binding ubiquitin protein ligase activity Rattus norvegicus Cytoplasm Lipoprotein Metal-binding Myristate Phosphoprotein Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger MGALTSRQHA MGALTSRQHAGVEEVDIPSNSVYRYPPKSGSYFASHFIMGGEKFDCTHPEGYLFGENSDLNFLGNRPVSFPYAAPPPHEPVKTLRSLINIRKDTLRLVKCAEEVKSHGEEAGKAKVHYNVEFTFDTDARVAITIYYQATEEFQNGIASYIPKDNSLQSETVHYKRGVCQQFCLPSHTVDPSEWAEEELGFDLDREVYPLVVHAVVDEGDEYFGHCHVLLGTFEKHSDGTFCVKPLKQKQVWDGVTYLLQEDYGIENKSNTQDFKVAEDDVRDNSAECVVCLSDVRDTLILPCRHCASCNVHCADTLRYQANNCPICRLPFRALLQIRAMRKKLGPLSPSSFNPIISSQTSDSEEHSSSENIPAGYEVVSLLEALNGPLTSSPAVPPLHVLGDGHLSGMLPSYGSDGHLPPVRTLSPLDHLSDCNSQGLKLNKSLSKSISQNSSVLHEEEDERSCSESDTQLSQRLSAQHPEEGPDVTPESENLTLSSSGAVDQSSCTGTPLSSTISSPEDPASSSLAQSVMSMASSQISTDTVSSMSGSYIAPGTEEEGEAPPSPRAASRAPSEEEETPAESPDSNFAGLPAGEQDAEGNDIMEEEDRSPVQEDGQRTCAFLGMECDNNNDFDVASVKALDNKLCSEVCLPGTWQHDAAIINRHNTQRRRLSPSSLEDPEEDRPCVWDPLAV |
cell morphogenesis involved in neuron differentiation central nervous system development central nervous system neuron differentiation diaphragm development dorsal/ventral neural tube patterning endocrine pancreas development motor neuron axon guidance negative regulation of transcription by RNA polymerase II nerve development neuron differentiation neuron migration neuron projection morphogenesis pancreas development post-embryonic development respiratory system development spinal cord motor neuron cell fate specification | chromatin; cytosol; nucleolus; nucleoplasm; nucleus | DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific double-stranded DNA binding | Rattus norvegicus | Acetylation Developmental protein DNA-binding Homeobox Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MEKSKNFRID | MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLAATPSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLTAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGSGGGAGKGGTEEKTEEELLGPPVSGDKASGRRLRDLRDSDPDEDEDDEEDHFPYSNGVGAHAASSDCSSEDDSPPPRPGGPGHQPLPQ | cell morphogenesis involved in neuron differentiation central nervous system development central nervous system neuron differentiation diaphragm development dorsal/ventral neural tube patterning endocrine pancreas development motor neuron axon guidance negative regulation of transcription by RNA polymerase II nerve development neuron differentiation neuron migration neuron projection morphogenesis pancreas development post-embryonic development respiratory system development spinal cord motor neuron cell fate specification chromatin; cytosol; nucleolus; nucleoplasm; nucleus DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific double-stranded DNA binding Rattus norvegicus Acetylation Developmental protein DNA-binding Homeobox Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MEKSKNFRID MEKSKNFRIDALLAVDPPRAASTQSAPLALVTSLAATPSGPGRGGSGGGGTSSGASRSCSPASSEATAAPGDRLRAESPSPPRLLTAHCALLPKPGFLGAGGGGGAAGGPGTPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYSYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFSSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGSGGGAGKGGTEEKTEEELLGPPVSGDKASGRRLRDLRDSDPDEDEDDEEDHFPYSNGVGAHAASSDCSSEDDSPPPRPGGPGHQPLPQ |
3'-UTR-mediated mRNA destabilization cell differentiation DNA damage response endocardial cushion development mRNA destabilization mRNA processing mRNA stabilization negative regulation of cytoplasmic translation positive regulation of 3'-UTR-mediated mRNA stabilization positive regulation of myotube differentiation positive regulation of skeletal muscle fiber differentiation positive regulation of stem cell differentiation regulation of alternative mRNA splicing, via spliceosome regulation of mRNA stability regulation of myotube differentiation RNA splicing | cytoplasm; cytosol; nucleus | mRNA 3'-UTR AU-rich region binding mRNA 3'-UTR binding mRNA CDS binding pre-mRNA intronic binding sequence-specific mRNA binding | Rattus norvegicus | Cytoplasm Differentiation mRNA processing mRNA splicing Nucleus Reference proteome RNA-binding Translation regulation | MHTTQKDTTY | MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAATGYVTTGGYSYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ | 3'-UTR-mediated mRNA destabilization cell differentiation DNA damage response endocardial cushion development mRNA destabilization mRNA processing mRNA stabilization negative regulation of cytoplasmic translation positive regulation of 3'-UTR-mediated mRNA stabilization positive regulation of myotube differentiation positive regulation of skeletal muscle fiber differentiation positive regulation of stem cell differentiation regulation of alternative mRNA splicing, via spliceosome regulation of mRNA stability regulation of myotube differentiation RNA splicing cytoplasm; cytosol; nucleus mRNA 3'-UTR AU-rich region binding mRNA 3'-UTR binding mRNA CDS binding pre-mRNA intronic binding sequence-specific mRNA binding Rattus norvegicus Cytoplasm Differentiation mRNA processing mRNA splicing Nucleus Reference proteome RNA-binding Translation regulation MHTTQKDTTY MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGDIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAATGYVTTGGYSYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ |
lipid droplet organization lipid storage mitochondrion localization negative regulation of fatty acid beta-oxidation negative regulation of lipase activity negative regulation of lipid catabolic process negative regulation of peroxisome proliferator activated receptor signaling pathway negative regulation of reactive oxygen species metabolic process negative regulation of triglyceride catabolic process positive regulation of fatty acid beta-oxidation positive regulation of lipase activity positive regulation of lipid storage positive regulation of sequestering of triglyceride positive regulation of triglyceride biosynthetic process | cytoplasm; cytosol; lipid droplet; mitochondrion | identical protein binding lipase binding | Rattus norvegicus | Cytoplasm Lipid droplet Mitochondrion Phosphoprotein Reference proteome | MDQRGKDTTL | MDQRGKDTTLALHSRMSGDQTAQDPGSSLGELDQHNVVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVNDLACRGLDKLEEKLPFLQQPSDTVVTSAKDAVAKSVTGVVDLAQRGRRWSGELRRSVSQAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATESQGPEVGSVEEQRQKQGYFVRLGSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRASPTPTFHHPKVQELCGDWSPCLENGYRHSQVELETLALSRSLTLELQSAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGQDSVAQAHACVDEFLDLVLRAMPLAWLVGPFAPILVERSEPLINLATCVDEVVGDPDPRWAHMDWPAQQRAWEAEPADPGGQEAEPPLGQVKHTMMPELDF | lipid droplet organization lipid storage mitochondrion localization negative regulation of fatty acid beta-oxidation negative regulation of lipase activity negative regulation of lipid catabolic process negative regulation of peroxisome proliferator activated receptor signaling pathway negative regulation of reactive oxygen species metabolic process negative regulation of triglyceride catabolic process positive regulation of fatty acid beta-oxidation positive regulation of lipase activity positive regulation of lipid storage positive regulation of sequestering of triglyceride positive regulation of triglyceride biosynthetic process cytoplasm; cytosol; lipid droplet; mitochondrion identical protein binding lipase binding Rattus norvegicus Cytoplasm Lipid droplet Mitochondrion Phosphoprotein Reference proteome MDQRGKDTTL MDQRGKDTTLALHSRMSGDQTAQDPGSSLGELDQHNVVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVNDLACRGLDKLEEKLPFLQQPSDTVVTSAKDAVAKSVTGVVDLAQRGRRWSGELRRSVSQAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATESQGPEVGSVEEQRQKQGYFVRLGSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRASPTPTFHHPKVQELCGDWSPCLENGYRHSQVELETLALSRSLTLELQSAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGQDSVAQAHACVDEFLDLVLRAMPLAWLVGPFAPILVERSEPLINLATCVDEVVGDPDPRWAHMDWPAQQRAWEAEPADPGGQEAEPPLGQVKHTMMPELDF |
long-chain fatty acid import into cell negative regulation of appetite positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of transcription by RNA polymerase II | cytoplasm; dense core granule; extracellular space; transport vesicle | neuropeptide hormone activity type 2 galanin receptor binding type 3 galanin receptor binding | Rattus norvegicus | Alternative splicing Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Hormone Reference proteome Secreted Signal | MKGPSILAVA | MKGPSILAVAALALLLVLSVLENSSGAPQRLSEKRNWTPQAMLYLKGAQGHRFISDQSRRKELADRPPPERRNPNLQLLTLPEAAALFLASLEKPQKDEGGDFDKSKLLEDRRFYW | long-chain fatty acid import into cell negative regulation of appetite positive regulation of gastro-intestinal system smooth muscle contraction positive regulation of transcription by RNA polymerase II cytoplasm; dense core granule; extracellular space; transport vesicle neuropeptide hormone activity type 2 galanin receptor binding type 3 galanin receptor binding Rattus norvegicus Alternative splicing Amidation Cleavage on pair of basic residues Cytoplasmic vesicle Hormone Reference proteome Secreted Signal MKGPSILAVA MKGPSILAVAALALLLVLSVLENSSGAPQRLSEKRNWTPQAMLYLKGAQGHRFISDQSRRKELADRPPPERRNPNLQLLTLPEAAALFLASLEKPQKDEGGDFDKSKLLEDRRFYW |
amyloid-beta clearance by transcytosis early endosome to late endosome transport endocytosis endosome organization intracellular protein transport phagocytosis positive regulation of exocytosis positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation postsynaptic neurotransmitter receptor internalization receptor internalization involved in canonical Wnt signaling pathway regulation of endosome size regulation of filopodium assembly regulation of long-term neuronal synaptic plasticity regulation of synaptic vesicle exocytosis synaptic vesicle endocytosis synaptic vesicle recycling vesicle-mediated transport | actin cytoskeleton; axon; axon terminus; cytoplasm; cytoplasmic side of early endosome membrane; cytosol; dendrite; early endosome; early phagosome; endocytic vesicle; endomembrane system; endosome; endosome membrane; glutamatergic synapse; melanosome; membrane raft; neuronal cell body; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; postsynaptic early endosome; postsynaptic endocytic zone membrane; protein-containing complex; recycling endosome; ruffle; somatodendritic compartment; synaptic vesicle; synaptic vesicle membrane; terminal bouton; zymogen granule membrane | G protein activity GDP binding GDP-dissociation inhibitor binding GTP binding GTPase activity guanyl nucleotide binding | Rattus norvegicus | Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Endocytosis Endosome GTP-binding Hydrolase Lipoprotein Membrane Nucleotide-binding Phagocytosis Phosphoprotein Prenylation Protein transport Reference proteome Transport | MANRGATRPN | MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFSRAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTPMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN | amyloid-beta clearance by transcytosis early endosome to late endosome transport endocytosis endosome organization intracellular protein transport phagocytosis positive regulation of exocytosis positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation postsynaptic neurotransmitter receptor internalization receptor internalization involved in canonical Wnt signaling pathway regulation of endosome size regulation of filopodium assembly regulation of long-term neuronal synaptic plasticity regulation of synaptic vesicle exocytosis synaptic vesicle endocytosis synaptic vesicle recycling vesicle-mediated transport actin cytoskeleton; axon; axon terminus; cytoplasm; cytoplasmic side of early endosome membrane; cytosol; dendrite; early endosome; early phagosome; endocytic vesicle; endomembrane system; endosome; endosome membrane; glutamatergic synapse; melanosome; membrane raft; neuronal cell body; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; postsynaptic early endosome; postsynaptic endocytic zone membrane; protein-containing complex; recycling endosome; ruffle; somatodendritic compartment; synaptic vesicle; synaptic vesicle membrane; terminal bouton; zymogen granule membrane G protein activity GDP binding GDP-dissociation inhibitor binding GTP binding GTPase activity guanyl nucleotide binding Rattus norvegicus Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Endocytosis Endosome GTP-binding Hydrolase Lipoprotein Membrane Nucleotide-binding Phagocytosis Phosphoprotein Prenylation Protein transport Reference proteome Transport MANRGATRPN MANRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFSRAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTPMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPAQPARSQCCSN |
defense response to virus | cytoplasm; nucleus | RNA binding translation initiation factor activity | Prunus domestica | Cytoplasm Disulfide bond Host-virus interaction Initiation factor Nucleus Plant defense Protein biosynthesis RNA-binding Translation regulation | MATEVAAAVP | MATEVAAAVPPPQLDAEENSGLEAAAAEAKIQPSSGPHKLERKWTFWFDNQSKPKQGAAWGSSLRKAYTFETVQEFWCLYDQVFKPSKFPPNADFHLFRAGVEPKWEDPECANGGKWTVTSRSKASLDTMWLETLMALIGEQFDEADEICGVVASVRQRQDKLALWTRNAANEAAQMGIGRKWKEIIDVTDKITYSFHDDSKRERSAKPRYNV | defense response to virus cytoplasm; nucleus RNA binding translation initiation factor activity Prunus domestica Cytoplasm Disulfide bond Host-virus interaction Initiation factor Nucleus Plant defense Protein biosynthesis RNA-binding Translation regulation MATEVAAAVP MATEVAAAVPPPQLDAEENSGLEAAAAEAKIQPSSGPHKLERKWTFWFDNQSKPKQGAAWGSSLRKAYTFETVQEFWCLYDQVFKPSKFPPNADFHLFRAGVEPKWEDPECANGGKWTVTSRSKASLDTMWLETLMALIGEQFDEADEICGVVASVRQRQDKLALWTRNAANEAAQMGIGRKWKEIIDVTDKITYSFHDDSKRERSAKPRYNV |
cell motility cilium movement inner dynein arm assembly | axonemal outer doublet; motile cilium | dynein complex binding | Chlamydomonas reinhardtii | 3D-structure Cell projection Cilium Coiled coil Cytoplasm Cytoskeleton Flagellum | MDEEGSATAR | MDEEGSATARAKMMPQTLVLDHVSPATRLLEKRRQMFEVQEALEAQKQDFNRKEEVFKRREEALKLKDLELQESLIRFSKFLQENDSKRARAEKKANDEIKARIQKEKEIEQLTEVLEELKSEKERILEVLEKNMRYQHYLESVLEVADEYQEVADLLLRHATLSATNADLKDHQRKCSELAEKVRTELQIYVKQKTDEILNLNNQVAKLKTELEGYEAEAMVQEAKKDSSLQIASQRTLEYGQVVLSADNIFNRCRSKSSIGHPAESNPLHQLDVIGNFVSDLGSIIKQFKQEQAKRASLASRAEIE | cell motility cilium movement inner dynein arm assembly axonemal outer doublet; motile cilium dynein complex binding Chlamydomonas reinhardtii 3D-structure Cell projection Cilium Coiled coil Cytoplasm Cytoskeleton Flagellum MDEEGSATAR MDEEGSATARAKMMPQTLVLDHVSPATRLLEKRRQMFEVQEALEAQKQDFNRKEEVFKRREEALKLKDLELQESLIRFSKFLQENDSKRARAEKKANDEIKARIQKEKEIEQLTEVLEELKSEKERILEVLEKNMRYQHYLESVLEVADEYQEVADLLLRHATLSATNADLKDHQRKCSELAEKVRTELQIYVKQKTDEILNLNNQVAKLKTELEGYEAEAMVQEAKKDSSLQIASQRTLEYGQVVLSADNIFNRCRSKSSIGHPAESNPLHQLDVIGNFVSDLGSIIKQFKQEQAKRASLASRAEIE |
fructose metabolic process | plasma membrane | flavin adenine dinucleotide binding fructose 5-dehydrogenase activity | Gluconobacter japonicus | 3D-structure Cell membrane Direct protein sequencing FAD Flavoprotein Membrane Oxidoreductase | MSNETLSADV | MSNETLSADVVIIGAGICGSLLAHKLVRNGLSVLLLDAGPRRDRSQIVENWRNMPPDNKSQYDYATPYPSVPWAPHTNYFPDNNYLIVKGPDRTAYKQGIIKGVGGTTWHWAASSWRYLPNDFKLHSTYGVGRDYAMSYDELEPYYYEAECEMGVMGPNGEEITPSAPRQNPWPMTSMPYGYGDRTFTEIVSKLGFSNTPVPQARNSRPYDGRPQCCGNNNCMPICPIGAMYNGVYAAIKAEKLGAKIIPNAVVYAMETDAKNRITAISFYDPDKQSHRVVAKTFVIAANGIETPKLLLLAANDRNPHGIANSSDLVGRNMMDHPGIGMSFQSAEPIWAGGGSVQMSSITNFRDGDFRSEYAATQIGYNNTAQNSRAGMKALSMGLVGKKLDEEIRRRTAHGVDIYANHEVLPDPNNRLVLSKDYKDALGIPHPEVTYDVGEYVRKSAAISRQRLMDIAKAMGGTEIEMTPYFTPNNHITGGTIMGHDPRDSVVDKWLRTHDHSNLFLATGATMAASGTVNSTLTMAALSLRAADAILNDLKQG | fructose metabolic process plasma membrane flavin adenine dinucleotide binding fructose 5-dehydrogenase activity Gluconobacter japonicus3D-structure Cell membrane Direct protein sequencing FAD Flavoprotein Membrane Oxidoreductase MSNETLSADV MSNETLSADVVIIGAGICGSLLAHKLVRNGLSVLLLDAGPRRDRSQIVENWRNMPPDNKSQYDYATPYPSVPWAPHTNYFPDNNYLIVKGPDRTAYKQGIIKGVGGTTWHWAASSWRYLPNDFKLHSTYGVGRDYAMSYDELEPYYYEAECEMGVMGPNGEEITPSAPRQNPWPMTSMPYGYGDRTFTEIVSKLGFSNTPVPQARNSRPYDGRPQCCGNNNCMPICPIGAMYNGVYAAIKAEKLGAKIIPNAVVYAMETDAKNRITAISFYDPDKQSHRVVAKTFVIAANGIETPKLLLLAANDRNPHGIANSSDLVGRNMMDHPGIGMSFQSAEPIWAGGGSVQMSSITNFRDGDFRSEYAATQIGYNNTAQNSRAGMKALSMGLVGKKLDEEIRRRTAHGVDIYANHEVLPDPNNRLVLSKDYKDALGIPHPEVTYDVGEYVRKSAAISRQRLMDIAKAMGGTEIEMTPYFTPNNHITGGTIMGHDPRDSVVDKWLRTHDHSNLFLATGATMAASGTVNSTLTMAALSLRAADAILNDLKQG |
animal organ morphogenesis cell differentiation fibroblast growth factor receptor signaling pathway positive regulation of cell division positive regulation of cell population proliferation positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell migration | cytoplasm; extracellular space | fibroblast growth factor receptor binding growth factor activity | Felis catus | Alternative splicing Glycoprotein Growth factor Mitogen Reference proteome Secreted Signal | MSLSFLLLLF | MSLSFLLLLFLSHLILSAWAHGEKHLAPKGQPGPAATGRNPAGASSSRSSRGTTSSSSSSVSSSHSASLGNQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEPAGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQLEQPELSFTVTVPEKKKPPSPVKPKVPLSAPRKSPNTVKYRLKFRFG | animal organ morphogenesis cell differentiation fibroblast growth factor receptor signaling pathway positive regulation of cell division positive regulation of cell population proliferation positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell migration cytoplasm; extracellular space fibroblast growth factor receptor binding growth factor activity Felis catus Alternative splicing Glycoprotein Growth factor Mitogen Reference proteome Secreted Signal MSLSFLLLLF MSLSFLLLLFLSHLILSAWAHGEKHLAPKGQPGPAATGRNPAGASSSRSSRGTTSSSSSSVSSSHSASLGNQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEPAGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQLEQPELSFTVTVPEKKKPPSPVKPKVPLSAPRKSPNTVKYRLKFRFG |
peptide catabolic process proteolysis | cytoplasm; membrane | metalloaminopeptidase activity peptide binding zinc ion binding | Felis catus | Aminopeptidase Developmental protein Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix Zinc | MGPPSSSGFY | MGPPSSSGFYVSRAVALLLAALAAALLLALAVLAALYGRCARVQPSDLHHSGVPDAASSPRGTQEEPLPTWPPRPTREPAGTATPGHWRPPGPWDQLRLPPWLVPLHYELELWPRLRPNEFQSPTLSFTGRVNITVRCAAATARLLLHSLFLDCESAEVRGPLSSGPRDGALGRVPVDDVWFAFDMQYMVLELGATLQPGSRYELQLSFSGLVYRDLREGLFFSIYTDQGERRALLASQMEPTFARSVFPCFDEPALKATFNITIIHHPSYGALSNMPKLGQSEKRDVNGSVWTVTTFSTTPHMPTYLVALAICDYDHVSRTERGQEIRIWARKDAIANGNAAFALNITGPIFSFLEDLFNISYPLPKTDIIALPTFDNSAMENWGLLIFDESLLLMQPNDQVTDKKAVISFILSHEIGHQWFGNLVTMNWWNDIWLKEGFASYFEFGVINYFNPKFRRNEVFFSNILHHVLSEDHALVSRAVSLKVENFTETSEINELFDLFTYNKGASLARMLSSFLNENVFISALKSYLKTFSYSNAEQDDLWRHFQMVVDNQSKILLPAPVKSIMDRWTHQSGFPVITLNVSTGAMKQEPFYLGKVQNQTLLTHNDTWIVPILWIKNGITQSLVWLDKSSEIFPEMQVSDSDHDWVILNLNMTGYYRVNYDKVGWKKLKQQLEKDPKAIPVIHRLQMIDDAFSLSKNNYVEIETALDLTKYLAEEDEIIVWYAVLVNLVTKDLVFDVNNYDMYPLLKKYLLKRLISIWNMYSTVIRENVAALQDDYLALVALEKLFETACWLGLEDCLQLSRELFKNWTNHPENEIPYPIKSVVLCYGVAFGSDEEWDFLLNMYSNKTKEEERIQLTYAMSCSKDPWILHRYLEYAVTAAPFTFNETNIMEVVAESEVGRYIVKDFLINNWQAVSERYGTQSLVNLMYIIGRTISTDLQITELQQFFGNMLEEHQKLTVRAKLQTIKNKNLENKKRNARMTAWLRKNT | peptide catabolic process proteolysis cytoplasm; membrane metalloaminopeptidase activity peptide binding zinc ion binding Felis catus Aminopeptidase Developmental protein Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix Zinc MGPPSSSGFY MGPPSSSGFYVSRAVALLLAALAAALLLALAVLAALYGRCARVQPSDLHHSGVPDAASSPRGTQEEPLPTWPPRPTREPAGTATPGHWRPPGPWDQLRLPPWLVPLHYELELWPRLRPNEFQSPTLSFTGRVNITVRCAAATARLLLHSLFLDCESAEVRGPLSSGPRDGALGRVPVDDVWFAFDMQYMVLELGATLQPGSRYELQLSFSGLVYRDLREGLFFSIYTDQGERRALLASQMEPTFARSVFPCFDEPALKATFNITIIHHPSYGALSNMPKLGQSEKRDVNGSVWTVTTFSTTPHMPTYLVALAICDYDHVSRTERGQEIRIWARKDAIANGNAAFALNITGPIFSFLEDLFNISYPLPKTDIIALPTFDNSAMENWGLLIFDESLLLMQPNDQVTDKKAVISFILSHEIGHQWFGNLVTMNWWNDIWLKEGFASYFEFGVINYFNPKFRRNEVFFSNILHHVLSEDHALVSRAVSLKVENFTETSEINELFDLFTYNKGASLARMLSSFLNENVFISALKSYLKTFSYSNAEQDDLWRHFQMVVDNQSKILLPAPVKSIMDRWTHQSGFPVITLNVSTGAMKQEPFYLGKVQNQTLLTHNDTWIVPILWIKNGITQSLVWLDKSSEIFPEMQVSDSDHDWVILNLNMTGYYRVNYDKVGWKKLKQQLEKDPKAIPVIHRLQMIDDAFSLSKNNYVEIETALDLTKYLAEEDEIIVWYAVLVNLVTKDLVFDVNNYDMYPLLKKYLLKRLISIWNMYSTVIRENVAALQDDYLALVALEKLFETACWLGLEDCLQLSRELFKNWTNHPENEIPYPIKSVVLCYGVAFGSDEEWDFLLNMYSNKTKEEERIQLTYAMSCSKDPWILHRYLEYAVTAAPFTFNETNIMEVVAESEVGRYIVKDFLINNWQAVSERYGTQSLVNLMYIIGRTISTDLQITELQQFFGNMLEEHQKLTVRAKLQTIKNKNLENKKRNARMTAWLRKNT |
defense response L-ascorbic acid catabolic process negative regulation of defense response to virus response to hydrogen peroxide response to jasmonic acid response to virus | extracellular region | copper ion binding L-ascorbate oxidase activity oxidoreductase activity | Brassica rapa subsp. pekinensis | Copper Disulfide bond Glycoprotein Metal-binding Oxidoreductase Plant defense Repeat Secreted Signal | MGMWWIVAVA | MGMWWIVAVAILAHTASAAVREYAWEVEYKFGWPDCKEGMVMAVNGQFPGPTIHALAGDTIVVHLTNKLATEGLVIHWHGIRQLGSPWADGAAGVTQCAISPGETFTYNFTVDKPGTHFYHGHYGMQRSAGLYGSLIIDVAKGKKEPLRYDGEFNLLLSDWWHEDVLSQEIGLSSRPMRWIGEAQSILINGRGQFNCSLAAQFSSTSLPTCTFKEGDQCAPQRLHVEPNKTYRIRLASSTALASLNFAVQGHKLVVVEADGNYITPFTTDDIDIYSGETYSVLLTTDQDPSQNYYITAGVRGRKPNTPPALTVLNYVTAPSSQLPTSPPPETPRWNDFDRSKNFSKKIFAAMGSPSPPETFDERLILLNTQNLIEGFTKWAINNVSLAVPGTPYLGSVKYNLRTGFNRSSPPKDYPVDYDIMTPPRNRNAKQGNVSCVFPFNVTVDVILQNANGLNANASEIHPWHLHGHDFWVLGYGEGKFKPGVDEKTYNLKNPPLRNTVALYPYGWTALRFVTDNPGVWFFHCHIEPHLHMGMGVVFAEGLNRIGKVPDEALGCGLTKQFLMNRNNP | defense response L-ascorbic acid catabolic process negative regulation of defense response to virus response to hydrogen peroxide response to jasmonic acid response to virus extracellular region copper ion binding L-ascorbate oxidase activity oxidoreductase activity Brassica rapa subsp. pekinensis Copper Disulfide bond Glycoprotein Metal-binding Oxidoreductase Plant defense Repeat Secreted Signal MGMWWIVAVA MGMWWIVAVAILAHTASAAVREYAWEVEYKFGWPDCKEGMVMAVNGQFPGPTIHALAGDTIVVHLTNKLATEGLVIHWHGIRQLGSPWADGAAGVTQCAISPGETFTYNFTVDKPGTHFYHGHYGMQRSAGLYGSLIIDVAKGKKEPLRYDGEFNLLLSDWWHEDVLSQEIGLSSRPMRWIGEAQSILINGRGQFNCSLAAQFSSTSLPTCTFKEGDQCAPQRLHVEPNKTYRIRLASSTALASLNFAVQGHKLVVVEADGNYITPFTTDDIDIYSGETYSVLLTTDQDPSQNYYITAGVRGRKPNTPPALTVLNYVTAPSSQLPTSPPPETPRWNDFDRSKNFSKKIFAAMGSPSPPETFDERLILLNTQNLIEGFTKWAINNVSLAVPGTPYLGSVKYNLRTGFNRSSPPKDYPVDYDIMTPPRNRNAKQGNVSCVFPFNVTVDVILQNANGLNANASEIHPWHLHGHDFWVLGYGEGKFKPGVDEKTYNLKNPPLRNTVALYPYGWTALRFVTDNPGVWFFHCHIEPHLHMGMGVVFAEGLNRIGKVPDEALGCGLTKQFLMNRNNP |
O antigen biosynthetic process | plasma membrane | glycosyltransferase activity | Escherichia coli | Cell inner membrane Cell membrane Glycosyltransferase Lipopolysaccharide biosynthesis Membrane Repeat Transferase | MHILIDVQGY | MHILIDVQGYQSESKVRGIGRSTPAMSRAIIENAGEHRVSILINGMYPIDNINDVKMAYRDLLTDEDMFIFSAVAPTAYRHIENHGRSKAAQAARDIAIANIAPDIVYVISFFEGHSDSYTVSIPADNVPWKTVCVCHDLIPLLNKERYLGDPNFREFYMNKLAEFERADAIFAISQSAAQEVIEYTDIASDRVLNISSAVGEEFAVIDYSAERIQSLKDKYSLPDEFILSLAMIEPRKNIEALIHAYSLLPAELQQRYPMVLAYKVQPEQLERILRLAESYGLSRSQLIFTGFLTDDDLIALYNLCKLFVFPSLHEGFGLPPLEAMRCGAATLGSNITSLPEVIGWEDAMFNPHDVQDIRRVMEKALTDEAFYRELKAHALAQSAKFSWANTAHLAIEGFTRLLQSSQETDAGQAESVTASRLQMMQKIDALSEVDRLGLAWAVARNSFKRHTRKLLVDISVLAQHDAKTGIQRVSRSILSELLKSGVPGYEVSAVYYTPGECYRYANQYLSSHFPGEFGADEPVLFSKDDVLIATDLTAHLFPELVTQIDSMRAAGAFACFVVHDILPLRRPEWSIEGIQRDFPIWLSCLAEHADRLICVSASVAEDVKAWIAENRHWVKPNPLQTVSNFHLGADLDASVPSTGMPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWREGKDYNLFIVGKQGWNVDSLCEKLRHHPQLNKKLFWLQNISDEFLAELYARSRALIFASQGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPSDIAKAVEEWLALYEQNAHPRSENINWLTWKQSAEFLLKNLPIIAPAAKQ | O antigen biosynthetic process plasma membrane glycosyltransferase activity Escherichia coliCell inner membrane Cell membrane Glycosyltransferase Lipopolysaccharide biosynthesis Membrane Repeat Transferase MHILIDVQGY MHILIDVQGYQSESKVRGIGRSTPAMSRAIIENAGEHRVSILINGMYPIDNINDVKMAYRDLLTDEDMFIFSAVAPTAYRHIENHGRSKAAQAARDIAIANIAPDIVYVISFFEGHSDSYTVSIPADNVPWKTVCVCHDLIPLLNKERYLGDPNFREFYMNKLAEFERADAIFAISQSAAQEVIEYTDIASDRVLNISSAVGEEFAVIDYSAERIQSLKDKYSLPDEFILSLAMIEPRKNIEALIHAYSLLPAELQQRYPMVLAYKVQPEQLERILRLAESYGLSRSQLIFTGFLTDDDLIALYNLCKLFVFPSLHEGFGLPPLEAMRCGAATLGSNITSLPEVIGWEDAMFNPHDVQDIRRVMEKALTDEAFYRELKAHALAQSAKFSWANTAHLAIEGFTRLLQSSQETDAGQAESVTASRLQMMQKIDALSEVDRLGLAWAVARNSFKRHTRKLLVDISVLAQHDAKTGIQRVSRSILSELLKSGVPGYEVSAVYYTPGECYRYANQYLSSHFPGEFGADEPVLFSKDDVLIATDLTAHLFPELVTQIDSMRAAGAFACFVVHDILPLRRPEWSIEGIQRDFPIWLSCLAEHADRLICVSASVAEDVKAWIAENRHWVKPNPLQTVSNFHLGADLDASVPSTGMPDNAQALLAAMAAAPSFIMVGTMEPRKGHAQTLAAFEELWREGKDYNLFIVGKQGWNVDSLCEKLRHHPQLNKKLFWLQNISDEFLAELYARSRALIFASQGEGFGLPLIEAAQKKLPVIIRDIPVFKEIAQEHAWYFSGEAPSDIAKAVEEWLALYEQNAHPRSENINWLTWKQSAEFLLKNLPIIAPAAKQ |
regulation of pH sodium ion import across plasma membrane | apical plasma membrane; early endosome membrane; plasma membrane; recycling endosome membrane | identical protein binding phosphatidylinositol binding sodium:proton antiporter activity | Triakis scyllium | Alternative promoter usage Antiport Cell membrane Endosome Ion transport Membrane Phosphoprotein Signal Sodium Sodium transport Transmembrane Transmembrane helix Transport | MGRNRSGCVA | MGRNRSGCVARCVSLTALVLLLCCPVVRSSEAETDPDSHTEHGDSHGGSREGNDTGFQIVTFRWEHVQTPYVIALWILVASLGKIVFHLSEKVTSVVPESALLIVLGLILGGIVWAADHSASFTLTPTVFFFYLLPPIVLDAGYFMPNRHFFGNLGTILTYAVIGTVWNAATTGLSLYGVFLLGLMGDLKAGLLEFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFNSFVEVGAGNVQGLDYFKGIVSFFVVSLGGTAVGIIFAFILSLVTRFTKHVRVIEPGFVFVISYLSYLTADMLSLSAILAITFCGICCQKYVKANLCEQSITTVRYAMKMLASGAETIIFMFLGISAVNPTIWTWNTAFILLTLVFISVYRVIGVVIQTWILNHYRVVQLEIIDQVVMSYGGLRGAVAFALVVLLDSNYVGERRLFVSTTIIVVYFTVIFQGLTIKPLVKWLKVKRSQHKEPLLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWTNFDRKYLSKIMMRKSAQISRDKILSVFRELNLKDAISYVSEGERKGSLAFIRSSSDVNVDFTGPRHSVVDSSVSAVLRESTSEVCLDMHAVENRAKSPKDREEIVTHHMLQQHLYKPRKRYRLNYSRHKLARSEGEKQDKEIFQRTMKKRLENFKPTKLGTNYTTKFRNMKKERAAKKKHSDAVPNGRLATHSVSFHVNKDSEVEDPADGGISFLITPASNDADETGTGIDNPSFSNEEDQSIYQMIPPWISNEETVIPSQRARLQIPRSPTNFRRLTPLQLSNRSIDAFLLADISDEHPLSFLPESSM | regulation of pH sodium ion import across plasma membrane apical plasma membrane; early endosome membrane; plasma membrane; recycling endosome membrane identical protein binding phosphatidylinositol binding sodium:proton antiporter activity Triakis scyllium Alternative promoter usage Antiport Cell membrane Endosome Ion transport Membrane Phosphoprotein Signal Sodium Sodium transport Transmembrane Transmembrane helix Transport MGRNRSGCVA MGRNRSGCVARCVSLTALVLLLCCPVVRSSEAETDPDSHTEHGDSHGGSREGNDTGFQIVTFRWEHVQTPYVIALWILVASLGKIVFHLSEKVTSVVPESALLIVLGLILGGIVWAADHSASFTLTPTVFFFYLLPPIVLDAGYFMPNRHFFGNLGTILTYAVIGTVWNAATTGLSLYGVFLLGLMGDLKAGLLEFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFNSFVEVGAGNVQGLDYFKGIVSFFVVSLGGTAVGIIFAFILSLVTRFTKHVRVIEPGFVFVISYLSYLTADMLSLSAILAITFCGICCQKYVKANLCEQSITTVRYAMKMLASGAETIIFMFLGISAVNPTIWTWNTAFILLTLVFISVYRVIGVVIQTWILNHYRVVQLEIIDQVVMSYGGLRGAVAFALVVLLDSNYVGERRLFVSTTIIVVYFTVIFQGLTIKPLVKWLKVKRSQHKEPLLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWTNFDRKYLSKIMMRKSAQISRDKILSVFRELNLKDAISYVSEGERKGSLAFIRSSSDVNVDFTGPRHSVVDSSVSAVLRESTSEVCLDMHAVENRAKSPKDREEIVTHHMLQQHLYKPRKRYRLNYSRHKLARSEGEKQDKEIFQRTMKKRLENFKPTKLGTNYTTKFRNMKKERAAKKKHSDAVPNGRLATHSVSFHVNKDSEVEDPADGGISFLITPASNDADETGTGIDNPSFSNEEDQSIYQMIPPWISNEETVIPSQRARLQIPRSPTNFRRLTPLQLSNRSIDAFLLADISDEHPLSFLPESSM |
axon guidance axon midline choice point recognition axonogenesis compound eye development netrin-activated signaling pathway peripheral nervous system neuron axonogenesis proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination regulation of axonogenesis regulation of locomotion involved in locomotory behavior | axonal growth cone; neuron projection; perikaryon | ubiquitin protein ligase activity zinc ion binding | Drosophila melanogaster | Alternative splicing Cell projection Coiled coil Metal-binding Neurogenesis Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger | MEDELRCPTC | MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLYGVFYPAVSINRGVTLTMHTAMDAPKMDYF | axon guidance axon midline choice point recognition axonogenesis compound eye development netrin-activated signaling pathway peripheral nervous system neuron axonogenesis proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination regulation of axonogenesis regulation of locomotion involved in locomotory behavior axonal growth cone; neuron projection; perikaryon ubiquitin protein ligase activity zinc ion binding Drosophila melanogaster Alternative splicing Cell projection Coiled coil Metal-binding Neurogenesis Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger MEDELRCPTC MEDELRCPTCKQLYANPVLLPCFHALCLGCALDIQTPYSPGSALPGAVNGAGAASAAGHNGLHGNGGGAGGGAAAPVTNPNGPGTRHSSHSSAASTASSNTGSESVTSDQDQSDKVSIFSEADSGVVCCSNTSRPVSYAGTGLLPGVGNVVAPPGAAYCLTCPLCRKLVFFDDGGVRNLPTYRAMEAIVDRFCAREALRCQMCETDPKVASLICEQCEIRYCDACRELTHPARGPLAKHTLVKPRGAAQQRESVCGEHEETLSQYCLSCKAPACGLCIGELRHQAHDVQSINVTCKAQKTELSHNLQQLSEKARSTTEFIQRLKGMSDKVTESCMEFERLVHAQCEALIQAIHDRREYLLEAIRMDKDTKIRILKDQQSNCTGKLQQTTGLIQFCIEALKETDSAAFLQVGSMLINRVTNTDMTWHQEVTNAAPRVSPIVDLTLDDAALARAIDNLNFIQMRAVKDGDERCPAAPMTPTILPSDCSAENNSVTVAWQPPNHSFVEGYVLELDDGSGGEFREVYCGKETICTVDGLHFNSMYNARVKAFNSAGEGEYSELIGLQTAEVAWFTFDPVLSGGAGSGLIFSKNNATVSVEGWEHRVALGSVGFSRGVHYWEFTIDNYTADTDPAFGVARIDVARNKMLGKDEKSFAMYIDRQRSWFQHNSIHERRVEGGITTGSTIGVLLDLERHTLSFLVNEMPQGSVAFRDLYGVFYPAVSINRGVTLTMHTAMDAPKMDYF |
actin filament organization chitin-based cuticle development dorsal closure epithelial cell migration, open tracheal system epithelium development female sex determination head involution midgut development mRNA methylation protein ubiquitination regulation of alternative mRNA splicing, via spliceosome regulation of cell adhesion segmentation | cytoplasmic vesicle; cytosol; nucleus; perinuclear region of cytoplasm; plasma membrane; RNA N6-methyladenosine methyltransferase complex | cadherin binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding | Drosophila melanogaster | Alternative splicing Cell membrane Cytoplasm Cytoplasmic vesicle Developmental protein Membrane Metal-binding Nucleus Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger | MDTEEVKRGR | MDTEEVKRGRGRGRGTRARGRGRGRGRGRGKKIDDSSIADAAALAASSCAALEDSPGRLDASEDSVMQELDKDGELETPGALEEPLPHGALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAVDMEADISQLEAPTFTTLSRGPPEPMLRLKWNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRHVAPQPPPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIASRPVLSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIHGGHSTLTLANLTRINNANAQECHQGKASLHHTLKKGTPHQSESVADASYYSSVLASFGSAAGNPGSGPPGGGATAAAQPANPSGSHSAVGPGALIGGSTDAPTGGSSGNWQQSQYYR | actin filament organization chitin-based cuticle development dorsal closure epithelial cell migration, open tracheal system epithelium development female sex determination head involution midgut development mRNA methylation protein ubiquitination regulation of alternative mRNA splicing, via spliceosome regulation of cell adhesion segmentation cytoplasmic vesicle; cytosol; nucleus; perinuclear region of cytoplasm; plasma membrane; RNA N6-methyladenosine methyltransferase complex cadherin binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding Drosophila melanogaster Alternative splicing Cell membrane Cytoplasm Cytoplasmic vesicle Developmental protein Membrane Metal-binding Nucleus Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger MDTEEVKRGR MDTEEVKRGRGRGRGTRARGRGRGRGRGRGKKIDDSSIADAAALAASSCAALEDSPGRLDASEDSVMQELDKDGELETPGALEEPLPHGALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAVDMEADISQLEAPTFTTLSRGPPEPMLRLKWNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCARAEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRHVAPQPPPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIASRPVLSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIHGGHSTLTLANLTRINNANAQECHQGKASLHHTLKKGTPHQSESVADASYYSSVLASFGSAAGNPGSGPPGGGATAAAQPANPSGSHSAVGPGALIGGSTDAPTGGSSGNWQQSQYYR |
positive regulation of embryonic development protein dephosphorylation | plasma membrane | myosin phosphatase activity phosphoprotein phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity | Drosophila melanogaster | Alternative splicing Cell membrane Hydrolase Membrane Reference proteome | MDATSIITQV | MDATSIITQVSRDDEQLNVYPSYPNDKDAWLGFSGSVWLPDCPADHAQLTHDVDRLKPQKRGLFHSLLCCWRRNRTKTNQNGTQIDGSTTPPPLPDQQRYLLPQVRLTDMHRKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLQKMGELYECVLFTASLAKYADPVADLLDKWNVFRARLFRESCVYYRGNYIKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLSKVDSVYSVLCNSNQPLNNQTNQQQHPQELQQAPNQLHQQLQQQQQQQTISATTVITQATTLSAPTMLNQQQTSPPSPQSELLQKT | positive regulation of embryonic development protein dephosphorylation plasma membrane myosin phosphatase activity phosphoprotein phosphatase activity RNA polymerase II CTD heptapeptide repeat phosphatase activity Drosophila melanogaster Alternative splicing Cell membrane Hydrolase Membrane Reference proteome MDATSIITQV MDATSIITQVSRDDEQLNVYPSYPNDKDAWLGFSGSVWLPDCPADHAQLTHDVDRLKPQKRGLFHSLLCCWRRNRTKTNQNGTQIDGSTTPPPLPDQQRYLLPQVRLTDMHRKCMVIDLDETLVHSSFKPIPNADFIVPVEIDGTVHQVYVLKRPHVDEFLQKMGELYECVLFTASLAKYADPVADLLDKWNVFRARLFRESCVYYRGNYIKDLNRLGRDLQKIVIVDNSPASYIFHPDNAVPVKSWFDDVTDCELRELIPLFEKLSKVDSVYSVLCNSNQPLNNQTNQQQHPQELQQAPNQLHQQLQQQQQQQTISATTVITQATTLSAPTMLNQQQTSPPSPQSELLQKT |
envenomation resulting in modulation of blood coagulation in another organism induction of platelet aggregation in another organism proteolysis | extracellular region; extraorganismal space | serine-type endopeptidase activity serine-type peptidase activity toxin activity | Gloydius halys | Direct protein sequencing Disulfide bond Fibrinogenolytic toxin Fibrinolytic toxin Glycoprotein Hemostasis impairing toxin Hydrolase Platelet aggregation activating toxin Protease Secreted Serine protease Toxin | MILGDDECNI | MILGDDECNINEHRFLVALYTSRTLFCGGTLINQEWVLTAAHCNMEDIQIKLGMHSKKVPNEDEQKRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSAHIAPLSLPSSPPSVGSVCRTMGWGRISSTKETYPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTCVGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIENIIAGNTDASCPP | envenomation resulting in modulation of blood coagulation in another organism induction of platelet aggregation in another organism proteolysis extracellular region; extraorganismal space serine-type endopeptidase activity serine-type peptidase activity toxin activity Gloydius halys Direct protein sequencing Disulfide bond Fibrinogenolytic toxin Fibrinolytic toxin Glycoprotein Hemostasis impairing toxin Hydrolase Platelet aggregation activating toxin Protease Secreted Serine protease Toxin MILGDDECNI MILGDDECNINEHRFLVALYTSRTLFCGGTLINQEWVLTAAHCNMEDIQIKLGMHSKKVPNEDEQKRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSAHIAPLSLPSSPPSVGSVCRTMGWGRISSTKETYPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTCVGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIENIIAGNTDASCPP |
anaphase-promoting complex-dependent catabolic process cell cycle cell division deactivation of mitotic spindle assembly checkpoint positive regulation of mitotic metaphase/anaphase transition protein polyubiquitination regulation of mitotic metaphase/anaphase transition ubiquitin-dependent protein catabolic process | cytosol; nucleus | ATP binding ubiquitin conjugating enzyme activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Cell division Mitosis Nucleotide-binding Reference proteome Transferase Ubl conjugation pathway | MDSDMQNQNP | MDSDMQNQNPHTNSKNSSSAGMAVDGHSVTKRLRSELMSLMMSNTPGISAFPDSDSNLLHWAGTITGPSDTYYEGLKFKISMSFPANYPYSPPTIIFTSPMWHPNVDMSGNICLDILKDKWSAVYNVQTILLSLQSLLGEPNNASPLNAQAAELWSKDPIEYKRLLMQRYKEIDEI | anaphase-promoting complex-dependent catabolic process cell cycle cell division deactivation of mitotic spindle assembly checkpoint positive regulation of mitotic metaphase/anaphase transition protein polyubiquitination regulation of mitotic metaphase/anaphase transition ubiquitin-dependent protein catabolic process cytosol; nucleus ATP binding ubiquitin conjugating enzyme activity Schizosaccharomyces pombe ATP-binding Cell cycle Cell division Mitosis Nucleotide-binding Reference proteome Transferase Ubl conjugation pathway MDSDMQNQNP MDSDMQNQNPHTNSKNSSSAGMAVDGHSVTKRLRSELMSLMMSNTPGISAFPDSDSNLLHWAGTITGPSDTYYEGLKFKISMSFPANYPYSPPTIIFTSPMWHPNVDMSGNICLDILKDKWSAVYNVQTILLSLQSLLGEPNNASPLNAQAAELWSKDPIEYKRLLMQRYKEIDEI |
apoptotic DNA fragmentation DNA metabolic process enucleate erythrocyte differentiation regulation of immune response | extracellular exosome; lysosome | deoxyribonuclease II activity DNA binding | Homo sapiens | Alternative splicing Apoptosis Developmental protein Disease variant Disulfide bond Endonuclease Glycoprotein Hydrolase Lysosome Nuclease Reference proteome Signal | MIPLLLAALL | MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGGWRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI | apoptotic DNA fragmentation DNA metabolic process enucleate erythrocyte differentiation regulation of immune response extracellular exosome; lysosome deoxyribonuclease II activity DNA binding Homo sapiens Alternative splicing Apoptosis Developmental protein Disease variant Disulfide bond Endonuclease Glycoprotein Hydrolase Lysosome Nuclease Reference proteome Signal MIPLLLAALL MIPLLLAALLCVPAGALTCYGDSGQPVDWFVVYKLPALRGSGEAAQRGLQYKYLDESSGGWRDGRALINSPEGAVGRSLQPLYRSNTSQLAFLLYNDQPPQPSKAQDSSMRGHTKGVLLLDHDGGFWLVHSVPNFPPPASSAAYSWPHSACTYGQTLLCVSFPFAQFSKMGKQLTYTYPWVYNYQLEGIFAQEFPDLENVVKGHHVSQEPWNSSITLTSQAGAVFQSFAKFSKFGDDLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSPKGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYKI |
ether lipid biosynthetic process lipid biosynthetic process | cytosol; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome | alkylglycerone-phosphate synthase activity FAD binding | Homo sapiens | Acetylation Cataract Disease variant Dwarfism FAD Flavoprotein Lipid biosynthesis Lipid metabolism Membrane Peroxisome Phosphoprotein Reference proteome Rhizomelic chondrodysplasia punctata Transferase Transit peptide | MAEAAAAAGG | MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSDTPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGNRNLL | ether lipid biosynthetic process lipid biosynthetic process cytosol; membrane; mitochondrion; peroxisomal matrix; peroxisomal membrane; peroxisome alkylglycerone-phosphate synthase activity FAD binding Homo sapiens Acetylation Cataract Disease variant Dwarfism FAD Flavoprotein Lipid biosynthesis Lipid metabolism Membrane Peroxisome Phosphoprotein Reference proteome Rhizomelic chondrodysplasia punctata Transferase Transit peptide MAEAAAAAGG MAEAAAAAGGTGLGAGASYGSAADRDRDPDPDRAGRRLRVLSGHLLGRPREALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFIFNKKGQIELTGKRYPLSGMGLPTFKEWIQNTLGVNVEHKTTSKASLNPSDTPPSVVNEDFLHDLKETNISYSQEADDRVFRAHGHCLHEIFLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYGLMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKESGYCTGHEPDSLEFSTVGGWVSTRASGMKKNIYGNIEDLVVHIKMVTPRGIIEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPVPEYQKYGSVAFPNFEQGVACLREIAKQRCAPASIRLMDNKQFQFGHALKPQVSSIFTSFLDGLKKFYITKFKGFDPNQLSVATLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYIRDLALEYYVLGESFETSAPWDRVVDLCRNVKERITRECKEKGVQFAPFSTCRVTQTYDAGACIYFYFAFNYRGISDPLTVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGNRNLL |
single fertilization ubiquitin-dependent ERAD pathway | endoplasmic reticulum; endoplasmic reticulum membrane; nucleolus; nucleoplasm; nucleus; ubiquitin ligase complex | protein-macromolecule adaptor activity ubiquitin binding | Homo sapiens | Alternative splicing Endoplasmic reticulum Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MASRGVVGIF | MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN | single fertilization ubiquitin-dependent ERAD pathway endoplasmic reticulum; endoplasmic reticulum membrane; nucleolus; nucleoplasm; nucleus; ubiquitin ligase complex protein-macromolecule adaptor activity ubiquitin binding Homo sapiens Alternative splicing Endoplasmic reticulum Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix MASRGVVGIF MASRGVVGIFFLSAVPLVCLELRRGIPDIGIKDFLLLCGRILLLLALLTLIISVTTSWLNSFKSPQVYLKEEEEKNEKRQKLVRKKQQEAQGEKASRYIENVLKPHQEMKLRKLEERFYQMTGEAWKLSSGHKLGGDEGTSQTSFETSNREAAKSQNLPKPLTEFPSPAEQPTCKEIPDLPEEPSQTAEEVVTVALRCPSGNVLRRRFLKSYSSQVLFDWMTRIGYHISLYSLSTSFPRRPLAVEGGQSLEDIGITVDTVLILEEKEQTN |
cell differentiation cell division microtubule cytoskeleton organization microtubule depolymerization microtubule-based movement mitotic spindle assembly mitotic spindle organization nervous system development regulation of cell migration | centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytosol; kinesin complex; membrane; microtubule; nuclear body; nucleolus; nucleoplasm; spindle; spindle pole | ATP binding ATP hydrolysis activity cytoskeletal motor activity microtubule binding microtubule motor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Developmental protein Differentiation Disease variant Lissencephaly Microtubule Mitosis Motor protein Neurogenesis Nucleotide-binding Phosphoprotein Reference proteome | MATANFGKIQ | MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARPSQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL | cell differentiation cell division microtubule cytoskeleton organization microtubule depolymerization microtubule-based movement mitotic spindle assembly mitotic spindle organization nervous system development regulation of cell migration centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytosol; kinesin complex; membrane; microtubule; nuclear body; nucleolus; nucleoplasm; spindle; spindle pole ATP binding ATP hydrolysis activity cytoskeletal motor activity microtubule binding microtubule motor activity Homo sapiens 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Developmental protein Differentiation Disease variant Lissencephaly Microtubule Mitosis Motor protein Neurogenesis Nucleotide-binding Phosphoprotein Reference proteome MATANFGKIQ MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIFSLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARPSQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQELREKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSSPQRDDLKLLCEQNEEEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYATQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL |
apoptotic process cellular response to aldosterone DNA damage response intracellular signal transduction long-term memory neuron projection morphogenesis positive regulation of transporter activity protein phosphorylation regulation of apoptotic process regulation of blood pressure regulation of catalytic activity regulation of cell growth regulation of cell migration regulation of cell population proliferation regulation of DNA-binding transcription factor activity regulation of gastric acid secretion regulation of signal transduction by p53 class mediator renal sodium ion absorption sodium ion transport | cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus; plasma membrane | ATP binding calcium channel regulator activity chloride channel regulator activity potassium channel regulator activity protein serine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity sodium channel regulator activity | Homo sapiens | 3D-structure Alternative promoter usage Alternative splicing Apoptosis ATP-binding Cell membrane Cytoplasm Disulfide bond Endoplasmic reticulum Kinase Membrane Mitochondrion Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Stress response Transferase Ubl conjugation | MTVKTEAAKG | MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL | apoptotic process cellular response to aldosterone DNA damage response intracellular signal transduction long-term memory neuron projection morphogenesis positive regulation of transporter activity protein phosphorylation regulation of apoptotic process regulation of blood pressure regulation of catalytic activity regulation of cell growth regulation of cell migration regulation of cell population proliferation regulation of DNA-binding transcription factor activity regulation of gastric acid secretion regulation of signal transduction by p53 class mediator renal sodium ion absorption sodium ion transport cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus; plasma membrane ATP binding calcium channel regulator activity chloride channel regulator activity potassium channel regulator activity protein serine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity sodium channel regulator activity Homo sapiens 3D-structure Alternative promoter usage Alternative splicing Apoptosis ATP-binding Cell membrane Cytoplasm Disulfide bond Endoplasmic reticulum Kinase Membrane Mitochondrion Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Stress response Transferase Ubl conjugation MTVKTEAAKG MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL |
deoxycytidine metabolic process DNA biosynthetic process nucleobase-containing compound metabolic process phosphorylation pyrimidine nucleoside salvage thymidine metabolic process | cytoplasm; mitochondrial matrix; mitochondrion | ATP binding deoxycytidine kinase activity deoxynucleoside kinase activity nucleoside kinase activity thymidine kinase activity | Homo sapiens | Alternative splicing ATP-binding Direct protein sequencing Disease variant DNA synthesis Kinase Mitochondrion Nucleotide-binding Primary mitochondrial disease Progressive external ophthalmoplegia Reference proteome Transferase Transit peptide | MLLWPLRGWA | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP | deoxycytidine metabolic process DNA biosynthetic process nucleobase-containing compound metabolic process phosphorylation pyrimidine nucleoside salvage thymidine metabolic process cytoplasm; mitochondrial matrix; mitochondrion ATP binding deoxycytidine kinase activity deoxynucleoside kinase activity nucleoside kinase activity thymidine kinase activity Homo sapiens Alternative splicing ATP-binding Direct protein sequencing Disease variant DNA synthesis Kinase Mitochondrion Nucleotide-binding Primary mitochondrial disease Progressive external ophthalmoplegia Reference proteome Transferase Transit peptide MLLWPLRGWA MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP |
B cell differentiation bone regeneration canonical Wnt signaling pathway learning or memory negative regulation of mitochondrial depolarization negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of necroptotic process negative regulation of neuron apoptotic process negative regulation of skeletal muscle acetylcholine-gated channel clustering nervous system development neuroblast proliferation non-canonical Wnt signaling pathway ossification positive regulation of apoptotic process positive regulation of bone mineralization positive regulation of canonical Wnt signaling pathway positive regulation of neural precursor cell proliferation postsynapse organization regulation of cell cycle regulation of cytosolic calcium ion concentration regulation of postsynaptic cytosolic calcium ion concentration regulation of skeletal muscle acetylcholine-gated channel clustering release of cytochrome c from mitochondria | cell surface; cytoplasm; endoplasmic reticulum membrane; filopodium membrane; glutamatergic synapse; Golgi apparatus; membrane; mitochondrial membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse | G protein-coupled receptor activity protein heterodimerization activity protein homodimerization activity Wnt receptor activity Wnt-protein binding | Homo sapiens | Cell membrane Developmental protein Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix Ubl conjugation Wnt signaling pathway | MAVAPLRGAL | MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL | B cell differentiation bone regeneration canonical Wnt signaling pathway learning or memory negative regulation of mitochondrial depolarization negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of necroptotic process negative regulation of neuron apoptotic process negative regulation of skeletal muscle acetylcholine-gated channel clustering nervous system development neuroblast proliferation non-canonical Wnt signaling pathway ossification positive regulation of apoptotic process positive regulation of bone mineralization positive regulation of canonical Wnt signaling pathway positive regulation of neural precursor cell proliferation postsynapse organization regulation of cell cycle regulation of cytosolic calcium ion concentration regulation of postsynaptic cytosolic calcium ion concentration regulation of skeletal muscle acetylcholine-gated channel clustering release of cytochrome c from mitochondria cell surface; cytoplasm; endoplasmic reticulum membrane; filopodium membrane; glutamatergic synapse; Golgi apparatus; membrane; mitochondrial membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse G protein-coupled receptor activity protein heterodimerization activity protein homodimerization activity Wnt receptor activity Wnt-protein binding Homo sapiens Cell membrane Developmental protein Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix Ubl conjugation Wnt signaling pathway MAVAPLRGAL MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL |
mRNA export from nucleus mRNA splicing, via spliceosome RNA export from nucleus | cytoplasm; membrane; nuclear speck; nucleoplasm; nucleus | ATP binding ATP hydrolysis activity identical protein binding RNA binding RNA helicase activity | Homo sapiens | Acetylation Alternative splicing ATP-binding Cytoplasm Helicase Hydrolase Isopeptide bond mRNA processing mRNA splicing Nucleotide-binding Nucleus Phosphoprotein Reference proteome RNA-binding Ubl conjugation | MAEQDVENDL | MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR | mRNA export from nucleus mRNA splicing, via spliceosome RNA export from nucleus cytoplasm; membrane; nuclear speck; nucleoplasm; nucleus ATP binding ATP hydrolysis activity identical protein binding RNA binding RNA helicase activity Homo sapiens Acetylation Alternative splicing ATP-binding Cytoplasm Helicase Hydrolase Isopeptide bond mRNA processing mRNA splicing Nucleotide-binding Nucleus Phosphoprotein Reference proteome RNA-binding Ubl conjugation MAEQDVENDL MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR |
actin cytoskeleton organization establishment or maintenance of actin cytoskeleton polarity fibroblast migration heart development maintenance of cell polarity muscle structure development regulation of transcription by RNA polymerase II response to hypoxia response to oxidative stress stress fiber assembly | adherens junction; cytoplasm; cytoskeleton; filamentous actin; focal adhesion; stress fiber; transcription regulator complex; Z disc | actin binding cadherin binding involved in cell-cell adhesion metal ion binding muscle alpha-actinin binding transcription coactivator activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Cytoskeleton Direct protein sequencing LIM domain Metal-binding Phosphoprotein Reference proteome Zinc | MTTQQIDLQG | MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPPEGYEVVTVFPK | actin cytoskeleton organization establishment or maintenance of actin cytoskeleton polarity fibroblast migration heart development maintenance of cell polarity muscle structure development regulation of transcription by RNA polymerase II response to hypoxia response to oxidative stress stress fiber assembly adherens junction; cytoplasm; cytoskeleton; filamentous actin; focal adhesion; stress fiber; transcription regulator complex; Z disc actin binding cadherin binding involved in cell-cell adhesion metal ion binding muscle alpha-actinin binding transcription coactivator activity Homo sapiens 3D-structure Acetylation Cytoplasm Cytoskeleton Direct protein sequencing LIM domain Metal-binding Phosphoprotein Reference proteome Zinc MTTQQIDLQG MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAHNRSAMPFTASPASSTTARVITNQYNNPAGLYSSENISNFNNALESKTAASGVEANSRPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSGFRSVKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERVTPPEGYEVVTVFPK |
acyl-CoA metabolic process coenzyme A biosynthetic process long-chain fatty-acyl-CoA catabolic process medium-chain fatty acid biosynthetic process medium-chain fatty-acyl-CoA catabolic process palmitic acid biosynthetic process | cytosol; extracellular exosome; mitochondrion; nucleoplasm | carboxylic ester hydrolase activity fatty-acyl-CoA binding long-chain fatty acyl-CoA binding myristoyl-CoA hydrolase activity palmitoyl-CoA hydrolase activity protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Fatty acid metabolism Hydrolase Lipid metabolism Mitochondrion Reference proteome Repeat Serine esterase | MKLLARALRL | MKLLARALRLCEFGRQASSRRLVAGQGCVGPRRGCCAPVQVVGPRADLPPCGACITGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP | acyl-CoA metabolic process coenzyme A biosynthetic process long-chain fatty-acyl-CoA catabolic process medium-chain fatty acid biosynthetic process medium-chain fatty-acyl-CoA catabolic process palmitic acid biosynthetic process cytosol; extracellular exosome; mitochondrion; nucleoplasm carboxylic ester hydrolase activity fatty-acyl-CoA binding long-chain fatty acyl-CoA binding myristoyl-CoA hydrolase activity palmitoyl-CoA hydrolase activity protein homodimerization activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Fatty acid metabolism Hydrolase Lipid metabolism Mitochondrion Reference proteome Repeat Serine esterase MKLLARALRL MKLLARALRLCEFGRQASSRRLVAGQGCVGPRRGCCAPVQVVGPRADLPPCGACITGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP |
G protein-coupled receptor signaling pathway | plasma membrane | G protein-coupled receptor activity | Homo sapiens | Cell membrane G-protein coupled receptor Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MAPTEPWSPS | MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASCCGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALPLPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASW | G protein-coupled receptor signaling pathway plasma membrane G protein-coupled receptor activity Homo sapiens Cell membrane G-protein coupled receptor Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix MAPTEPWSPS MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASCCGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALPLPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASW |
exocytosis histamine secretion by mast cell membrane fusion post-Golgi vesicle-mediated transport protein transport synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle priming vesicle targeting | adherens junction; azurophil granule; cytoplasm; extracellular exosome; focal adhesion; mitochondrion; neuron projection; nucleoplasm; phagocytic vesicle membrane; plasma membrane; presynapse; SNARE complex; specific granule; specific granule membrane; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; tertiary granule membrane | SNAP receptor activity syntaxin binding syntaxin-1 binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell membrane Coiled coil Direct protein sequencing Lipoprotein Membrane Palmitate Phosphoprotein Protein transport Reference proteome Repeat Synapse Synaptosome Transport | MDNLSSEEIQ | MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS | exocytosis histamine secretion by mast cell membrane fusion post-Golgi vesicle-mediated transport protein transport synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle priming vesicle targeting adherens junction; azurophil granule; cytoplasm; extracellular exosome; focal adhesion; mitochondrion; neuron projection; nucleoplasm; phagocytic vesicle membrane; plasma membrane; presynapse; SNARE complex; specific granule; specific granule membrane; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; tertiary granule membrane SNAP receptor activity syntaxin binding syntaxin-1 binding Homo sapiens 3D-structure Acetylation Alternative splicing Cell membrane Coiled coil Direct protein sequencing Lipoprotein Membrane Palmitate Phosphoprotein Protein transport Reference proteome Repeat Synapse Synaptosome Transport MDNLSSEEIQ MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS |
cellular response to cytokine stimulus granulocyte colony-stimulating factor signaling pathway negative regulation of apoptotic process positive regulation of granulocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of transcription by RNA polymerase II regulation of actin filament organization regulation of actin filament polymerization regulation of apoptotic process regulation of autophagy of mitochondrion regulation of protein targeting to mitochondrion | actin cytoskeleton; apical plasma membrane; cell cortex; clathrin-coated vesicle; endoplasmic reticulum; lamellipodium; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear membrane; P-body; sarcoplasmic reticulum; transcription regulator complex | interleukin-1 binding signaling adaptor activity | Homo sapiens | Acetylation Alternative splicing Cell membrane Cytoplasm Cytoplasmic vesicle Direct protein sequencing Disease variant Endoplasmic reticulum Membrane Mitochondrion Nucleus Phosphoprotein Reference proteome Sarcoplasmic reticulum | MSLFDLFRGF | MSLFDLFRGFFGFPGPRSHRDPFFGGMTRDEDDDEEEEEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR | cellular response to cytokine stimulus granulocyte colony-stimulating factor signaling pathway negative regulation of apoptotic process positive regulation of granulocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of transcription by RNA polymerase II regulation of actin filament organization regulation of actin filament polymerization regulation of apoptotic process regulation of autophagy of mitochondrion regulation of protein targeting to mitochondrion actin cytoskeleton; apical plasma membrane; cell cortex; clathrin-coated vesicle; endoplasmic reticulum; lamellipodium; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear membrane; P-body; sarcoplasmic reticulum; transcription regulator complex interleukin-1 binding signaling adaptor activity Homo sapiens Acetylation Alternative splicing Cell membrane Cytoplasm Cytoplasmic vesicle Direct protein sequencing Disease variant Endoplasmic reticulum Membrane Mitochondrion Nucleus Phosphoprotein Reference proteome Sarcoplasmic reticulum MSLFDLFRGF MSLFDLFRGFFGFPGPRSHRDPFFGGMTRDEDDDEEEEEEGGSWGRGNPRFHSPQHPPEEFGFGFSFSPGGGIRFHDNFGFDDLVRDFNSIFSDMGAWTLPSHPPELPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQPAPDWGSQRPFHRFDDVWPMDPHPRTREDNDLDSQVSQEGLGPVLQPQPKSYFKSISVTKITKPDGIVEERRTVVDSEGRTETTVTRHEADSSPRGDPESPRPPALDDAFSILDLFLGRWFRSR |
anatomical structure development cell differentiation DNA repair extrinsic apoptotic signaling pathway in absence of ligand mesodermal cell fate specification mitochondrial outer membrane permeabilization negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of DNA repair striated muscle tissue development | cytosol; mitochondrion; nucleoplasm; nucleus | histone H2AXY142 phosphatase activity magnesium ion binding protein tyrosine phosphatase activity | Homo sapiens | 3D-structure Activator Alternative splicing Chromatin regulator Cytoplasm Developmental protein DNA damage DNA repair Hydrolase Magnesium Metal-binding Nucleus Protein phosphatase Reference proteome Transcription Transcription regulation | MVELVISPSL | MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL | anatomical structure development cell differentiation DNA repair extrinsic apoptotic signaling pathway in absence of ligand mesodermal cell fate specification mitochondrial outer membrane permeabilization negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of DNA repair striated muscle tissue development cytosol; mitochondrion; nucleoplasm; nucleus histone H2AXY142 phosphatase activity magnesium ion binding protein tyrosine phosphatase activity Homo sapiens 3D-structure Activator Alternative splicing Chromatin regulator Cytoplasm Developmental protein DNA damage DNA repair Hydrolase Magnesium Metal-binding Nucleus Protein phosphatase Reference proteome Transcription Transcription regulation MVELVISPSL MVELVISPSLTVNSDCLDKLKFNRADAAVWTLSDRQGITKSAPLRVSQLFSRSCPRVLPRQPSTAMAAYGQTQYSAGIQQATPYTAYPPPAQAYGIPSYSIKTEDSLNHSPGQSGFLSYGSSFSTSPTGQSPYTYQMHGTTGFYQGGNGLGNAAGFGSVHQDYPSYPGFPQSQYPQYYGSSYNPPYVPASSICPSPLSTSTYVLQEASHNVPNQSSESLAGEYNTHNGPSTPAKEGDTDRPHRASDGKLRGRSKRSSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSSAPGANLCLGSGVHGGVDWMRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL |
chloride transport muscle contraction negative regulation of protein glutathionylation positive regulation of sodium ion export across plasma membrane potassium ion transport regulation of cardiac muscle cell membrane potential regulation of heart contraction regulation of sodium ion transmembrane transporter activity sodium ion transport | apical plasma membrane; caveola; intercalated disc; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule | chloride channel activity sodium channel regulator activity transmembrane transporter binding | Homo sapiens | 3D-structure Cell membrane Glutathionylation Ion transport Lipoprotein Membrane Palmitate Phosphoprotein Potassium Potassium transport Reference proteome Signal Sodium Sodium transport Sodium/potassium transport Transmembrane Transmembrane helix Transport | MASLGHILVF | MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR | chloride transport muscle contraction negative regulation of protein glutathionylation positive regulation of sodium ion export across plasma membrane potassium ion transport regulation of cardiac muscle cell membrane potential regulation of heart contraction regulation of sodium ion transmembrane transporter activity sodium ion transport apical plasma membrane; caveola; intercalated disc; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule chloride channel activity sodium channel regulator activity transmembrane transporter binding Homo sapiens 3D-structure Cell membrane Glutathionylation Ion transport Lipoprotein Membrane Palmitate Phosphoprotein Potassium Potassium transport Reference proteome Signal Sodium Sodium transport Sodium/potassium transport Transmembrane Transmembrane helix Transport MASLGHILVF MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR |
protein maturation by protein folding protein targeting to mitochondrion regulation of protein kinase A signaling xenobiotic metabolic process | aryl hydrocarbon receptor complex; cytoplasm; cytosol; membrane; nucleoplasm | aryl hydrocarbon receptor binding GAF domain binding peptidyl-prolyl cis-trans isomerase activity transcription coactivator activity unfolded protein binding | Homo sapiens | 3D-structure Cushing syndrome Cytoplasm Phosphoprotein Reference proteome Repeat TPR repeat | MADIIARLRE | MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH | protein maturation by protein folding protein targeting to mitochondrion regulation of protein kinase A signaling xenobiotic metabolic process aryl hydrocarbon receptor complex; cytoplasm; cytosol; membrane; nucleoplasm aryl hydrocarbon receptor binding GAF domain binding peptidyl-prolyl cis-trans isomerase activity transcription coactivator activity unfolded protein binding Homo sapiens 3D-structure Cushing syndrome Cytoplasm Phosphoprotein Reference proteome Repeat TPR repeat MADIIARLRE MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSDDEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVAKSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESPGTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQPGSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHAAVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH |
cell-cell signaling cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis cytoskeleton organization eosinophil chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response lymphocyte chemotaxis monocyte chemotaxis neutrophil chemotaxis positive regulation of actin filament polymerization positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of eosinophil migration positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity positive regulation of inflammatory response regulation of cell shape signal transduction | extracellular space | CCR chemokine receptor binding CCR3 chemokine receptor binding chemokine activity receptor ligand activity | Homo sapiens | 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Glycoprotein Inflammatory response Reference proteome Secreted Signal | MAGLMTIVTS | MAGLMTIVTSLLFLGVCAHHIIPTGSVVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQFCGDPKQEWVQRYMKNLDAKQKKASPRARAVAVKGPVQRYPGNQTTC | cell-cell signaling cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to type II interferon chemokine-mediated signaling pathway chemotaxis cytoskeleton organization eosinophil chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response lymphocyte chemotaxis monocyte chemotaxis neutrophil chemotaxis positive regulation of actin filament polymerization positive regulation of angiogenesis positive regulation of cell migration positive regulation of endothelial cell proliferation positive regulation of eosinophil migration positive regulation of ERK1 and ERK2 cascade positive regulation of GTPase activity positive regulation of inflammatory response regulation of cell shape signal transduction extracellular space CCR chemokine receptor binding CCR3 chemokine receptor binding chemokine activity receptor ligand activity Homo sapiens 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Glycoprotein Inflammatory response Reference proteome Secreted Signal MAGLMTIVTS MAGLMTIVTSLLFLGVCAHHIIPTGSVVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQFCGDPKQEWVQRYMKNLDAKQKKASPRARAVAVKGPVQRYPGNQTTC |
potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential response to nicotine sodium ion transmembrane transport stabilization of membrane potential | apical plasma membrane; brush border membrane; dendrite; intracellular membrane-bounded organelle; inward rectifier potassium channel complex; membrane; perikaryon; plasma membrane; potassium channel complex; recycling endosome; synaptic membrane; voltage-gated potassium channel complex | identical protein binding inward rectifier potassium channel activity outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity sodium channel activity | Homo sapiens | 3D-structure Cell membrane Cell projection Cytoplasmic vesicle Disulfide bond Endosome Glycoprotein Ion channel Ion transport Isopeptide bond Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Synapse Transmembrane Transmembrane helix Transport Ubl conjugation | MLQSLAGSSC | MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH | potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential response to nicotine sodium ion transmembrane transport stabilization of membrane potential apical plasma membrane; brush border membrane; dendrite; intracellular membrane-bounded organelle; inward rectifier potassium channel complex; membrane; perikaryon; plasma membrane; potassium channel complex; recycling endosome; synaptic membrane; voltage-gated potassium channel complex identical protein binding inward rectifier potassium channel activity outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity sodium channel activity Homo sapiens 3D-structure Cell membrane Cell projection Cytoplasmic vesicle Disulfide bond Endosome Glycoprotein Ion channel Ion transport Isopeptide bond Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Synapse Transmembrane Transmembrane helix Transport Ubl conjugation MLQSLAGSSC MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPANH |
brain development cellular response to type II interferon insulin secretion intracellular glucose homeostasis intracellular protein transport negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import neurotransmitter secretion neutrophil degranulation platelet aggregation protein to membrane docking response to insulin vesicle docking involved in exocytosis vesicle-mediated transport | apical plasma membrane; basolateral plasma membrane; cytosol; extracellular exosome; phagocytic vesicle; plasma membrane; platelet alpha granule; presynapse; secretory granule; specific granule; tertiary granule | protein-containing complex binding syntaxin binding syntaxin-1 binding | Homo sapiens | Cell membrane Cytoplasm Membrane Phosphoprotein Protein transport Reference proteome Transport | MAPPVAERGL | MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE | brain development cellular response to type II interferon insulin secretion intracellular glucose homeostasis intracellular protein transport negative regulation of calcium ion-dependent exocytosis negative regulation of glucose import neurotransmitter secretion neutrophil degranulation platelet aggregation protein to membrane docking response to insulin vesicle docking involved in exocytosis vesicle-mediated transport apical plasma membrane; basolateral plasma membrane; cytosol; extracellular exosome; phagocytic vesicle; plasma membrane; platelet alpha granule; presynapse; secretory granule; specific granule; tertiary granule protein-containing complex binding syntaxin binding syntaxin-1 binding Homo sapiens Cell membrane Cytoplasm Membrane Phosphoprotein Protein transport Reference proteome Transport MAPPVAERGL MAPPVAERGLKSVVWQKIKATVFDDCKKEGEWKIMLLDEFTTKLLASCCKMTDLLEEGITVVENIYKNREPVRQMKALYFITPTSKSVDCFLHDFASKSENKYKAAYIYFTDFCPDNLFNKIKASCSKSIRRCKEINISFIPHESQVYTLDVPDAFYYCYSPDPGNAKGKDAIMETMADQIVTVCATLDENPGVRYKSKPLDNASKLAQLVEKKLEDYYKIDEKSLIKGKTHSQLLIIDRGFDPVSTVLHELTFQAMAYDLLPIENDTYKYKTDGKEKEAILEEEDDLWVRIRHRHIAVVLEEIPKLMKEISSTKKATEGKTSLSALTQLMKKMPHFRKQITKQVVHLNLAEDCMNKFKLNIEKLCKTEQDLALGTDAEGQKVKDSMRVLLPVLLNKNHDNCDKIRAILLYIFSINGTTEENLDRLIQNVKIENESDMIRNWSYLGVPIVPQSQQGKPLRKDRSAEETFQLSRWTPFIKDIMEDAIDNRLDSKEWPYCSQCPAVWNGSGAVSARQKPRANYLEDRKNGSKLIVFVIGGITYSEVRCAYEVSQAHKSCEVIIGSTHVLTPKKLLDDIKMLNKPKDKVSLIKDE |
complement activation, classical pathway complement activation, lectin pathway proteolysis | extracellular exosome; extracellular region; extracellular space | calcium ion binding calcium-dependent protein binding complement component C4b binding identical protein binding peptidase activity serine-type endopeptidase activity | Homo sapiens | 3D-structure Alternative splicing Autocatalytic cleavage Calcium Complement pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Hydrolase Hydroxylation Immunity Innate immunity Metal-binding Protease Reference proteome Repeat Secreted Serine protease Signal Sushi | MRLLTLLGLL | MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF | complement activation, classical pathway complement activation, lectin pathway proteolysis extracellular exosome; extracellular region; extracellular space calcium ion binding calcium-dependent protein binding complement component C4b binding identical protein binding peptidase activity serine-type endopeptidase activity Homo sapiens 3D-structure Alternative splicing Autocatalytic cleavage Calcium Complement pathway Direct protein sequencing Disease variant Disulfide bond EGF-like domain Hydrolase Hydroxylation Immunity Innate immunity Metal-binding Protease Reference proteome Repeat Secreted Serine protease Signal Sushi MRLLTLLGLL MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISDF |
autophagosome assembly Golgi to endosome transport Golgi to lysosome transport intracellular protein transport post-Golgi vesicle-mediated transport protein localization protein localization to basolateral plasma membrane protein targeting protein targeting to lysosome vesicle-mediated transport | AP-4 adaptor complex; clathrin adaptor complex; cytoplasmic vesicle; cytosol; early endosome; endosome lumen; extracellular exosome; trans-Golgi network; trans-Golgi network membrane | protein domain specific binding protein transmembrane transporter activity | Homo sapiens | 3D-structure Endosome Golgi apparatus Hereditary spastic paraplegia Membrane Neurodegeneration Protein transport Reference proteome Transport | MISQFFILSS | MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI | autophagosome assembly Golgi to endosome transport Golgi to lysosome transport intracellular protein transport post-Golgi vesicle-mediated transport protein localization protein localization to basolateral plasma membrane protein targeting protein targeting to lysosome vesicle-mediated transport AP-4 adaptor complex; clathrin adaptor complex; cytoplasmic vesicle; cytosol; early endosome; endosome lumen; extracellular exosome; trans-Golgi network; trans-Golgi network membrane protein domain specific binding protein transmembrane transporter activity Homo sapiens 3D-structure Endosome Golgi apparatus Hereditary spastic paraplegia Membrane Neurodegeneration Protein transport Reference proteome Transport MISQFFILSS MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI |
cell adhesion cell-cell adhesion cell-cell junction assembly mRNA processing RNA splicing | adherens junction; cytoplasm; messenger ribonucleoprotein complex; nucleus; plasma membrane | cadherin binding | Homo sapiens | Alternative splicing Cell adhesion Cell junction Coiled coil Cytoplasm Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat | MEDCNVHSAA | MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMVSGGMGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPVATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDTRSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDALGPDGYSTVDRRERRPRGASSAGEASEKEPLKLDPSRKAPPPGPSRPAVRLVDAVGDAKPQPVDSWV | cell adhesion cell-cell adhesion cell-cell junction assembly mRNA processing RNA splicing adherens junction; cytoplasm; messenger ribonucleoprotein complex; nucleus; plasma membrane cadherin binding Homo sapiens Alternative splicing Cell adhesion Cell junction Coiled coil Cytoplasm Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat MEDCNVHSAA MEDCNVHSAASILASVKEQEARFERLTRALEQERRHVALQLERAQQPGMVSGGMGSGQPLPMAWQQLVLQEQSPGSQASLATMPEAPDVLEETVTVEEDPGTPTSHVSIVTSEDGTTRRTETKVTKTVKTVTTRTVRQVPVGPDGLPLLDGGPPLGPFADGALDRHFLLRGGGPVATLSRAYLSSGGGFPEGPEPRDSPSYGSLSRGLGMRPPRAGPLGPGPGDGCFTLPGHREAFPVGPEPGPPGGRSLPERFQAEPYGLEDDTRSLAADDEGGPELEPDYGTATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLDRLVRRSPSVDSARKEPRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAEWTTVFKNTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHKEVPGADRYQEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRTEAAKGFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGACLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREAKAASHVLQTVWSYKELRGTLQKDGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDALGPDGYSTVDRRERRPRGASSAGEASEKEPLKLDPSRKAPPPGPSRPAVRLVDAVGDAKPQPVDSWV |
anterograde axonal protein transport exocytosis multivesicular body sorting pathway positive regulation of exocytosis synaptic vesicle endocytosis | apical plasma membrane; axon cytoplasm; exocytic vesicle; extracellular exosome; Golgi apparatus; Golgi stack; late endosome; melanosome; multivesicular body membrane; plasma membrane; platelet dense granule membrane; secretory granule; synaptic vesicle membrane; trans-Golgi network transport vesicle; zymogen granule membrane | G protein activity GDP binding GTP binding GTPase activity myosin V binding protein domain specific binding | Homo sapiens | 3D-structure Acetylation Direct protein sequencing Disulfide bond Endosome GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MTDGDYDYLI | MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC | anterograde axonal protein transport exocytosis multivesicular body sorting pathway positive regulation of exocytosis synaptic vesicle endocytosis apical plasma membrane; axon cytoplasm; exocytic vesicle; extracellular exosome; Golgi apparatus; Golgi stack; late endosome; melanosome; multivesicular body membrane; plasma membrane; platelet dense granule membrane; secretory granule; synaptic vesicle membrane; trans-Golgi network transport vesicle; zymogen granule membrane G protein activity GDP binding GTP binding GTPase activity myosin V binding protein domain specific binding Homo sapiens 3D-structure Acetylation Direct protein sequencing Disulfide bond Endosome GTP-binding Hydrolase Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome MTDGDYDYLI MTDGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFKVHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIGNKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDTVNGGNSGNLDGEKPPEKKCIC |
3'-phosphoadenosine 5'-phosphosulfate metabolic process cholesterol metabolic process negative regulation of cell population proliferation positive regulation of epidermal cell differentiation steroid metabolic process sulfation | cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; intracellular membrane-bounded organelle; nucleus | cholesterol binding cholesterol sulfotransferase activity nucleic acid binding small molecule binding steroid hormone binding steroid sulfotransferase activity sulfotransferase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Endoplasmic reticulum Ichthyosis Lipid metabolism Microsome Nucleus Phosphoprotein Reference proteome Steroid metabolism Transferase | MDGPAEPQIP | MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS | 3'-phosphoadenosine 5'-phosphosulfate metabolic process cholesterol metabolic process negative regulation of cell population proliferation positive regulation of epidermal cell differentiation steroid metabolic process sulfation cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; intracellular membrane-bounded organelle; nucleus cholesterol binding cholesterol sulfotransferase activity nucleic acid binding small molecule binding steroid hormone binding steroid sulfotransferase activity sulfotransferase activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Disease variant Endoplasmic reticulum Ichthyosis Lipid metabolism Microsome Nucleus Phosphoprotein Reference proteome Steroid metabolism Transferase MDGPAEPQIP MDGPAEPQIPGLWDTYEDDISEISQKLPGEYFRYKGVPFPVGLYSLESISLAENTQDVRDDDIFIITYPKSGTTWMIEIICLILKEGDPSWIRSVPIWERAPWCETIVGAFSLPDQYSPRLMSSHLPIQIFTKAFFSSKAKVIYMGRNPRDVVVSLYHYSKIAGQLKDPGTPDQFLRDFLKGEVQFGSWFDHIKGWLRMKGKDNFLFITYEELQQDLQGSVERICGFLGRPLGKEALGSVVAHSTFSAMKANTMSNYTLLPPSLLDHRRGAFLRKGVCGDWKNHFTVAQSEAFDRAYRKQMRGMPTFPWDEDPEEDGSPDPEPSPEPEPKPSLEPNTSLEREPRPNSSPSPSPGQASETPHPRPS |
actin filament bundle assembly actin filament organization cell migration focal adhesion assembly lamellipodium assembly positive regulation of cell adhesion positive regulation of cell migration regulation of small GTPase mediated signal transduction Rho protein signal transduction signal transduction | cytosol; early endosome; endosome membrane; Golgi membrane; mitochondrial outer membrane; plasma membrane | GTP binding GTPase activity guanyl-nucleotide exchange factor activity protein kinase binding | Homo sapiens | 3D-structure Cell membrane Endosome GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MTAAQAAGEE | MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT | actin filament bundle assembly actin filament organization cell migration focal adhesion assembly lamellipodium assembly positive regulation of cell adhesion positive regulation of cell migration regulation of small GTPase mediated signal transduction Rho protein signal transduction signal transduction cytosol; early endosome; endosome membrane; Golgi membrane; mitochondrial outer membrane; plasma membrane GTP binding GTPase activity guanyl-nucleotide exchange factor activity protein kinase binding Homo sapiens 3D-structure Cell membrane Endosome GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome MTAAQAAGEE MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT |
apoptotic process axonogenesis chromatin organization DNA damage response negative regulation of cell cycle G1/S phase transition negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process positive regulation of DNA-templated transcription positive regulation of neuron projection development positive regulation of protein secretion positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription signal transduction smooth muscle contraction | cytoplasm; endoplasmic reticulum; growth cone; lamellipodium; nuclear speck; nucleoplasm; nucleus; plasma membrane; synapse | amyloid-beta binding chromatin binding histone binding low-density lipoprotein particle receptor binding molecular adaptor activity proline-rich region binding transcription coactivator activity ubiquitin protein ligase binding | Homo sapiens | 3D-structure Acetylation Activator Alternative splicing Apoptosis Cell membrane Cell projection Chromatin regulator Cytoplasm DNA damage Membrane Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation | MSVPSSLSQS | MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP | apoptotic process axonogenesis chromatin organization DNA damage response negative regulation of cell cycle G1/S phase transition negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process positive regulation of DNA-templated transcription positive regulation of neuron projection development positive regulation of protein secretion positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription signal transduction smooth muscle contraction cytoplasm; endoplasmic reticulum; growth cone; lamellipodium; nuclear speck; nucleoplasm; nucleus; plasma membrane; synapse amyloid-beta binding chromatin binding histone binding low-density lipoprotein particle receptor binding molecular adaptor activity proline-rich region binding transcription coactivator activity ubiquitin protein ligase binding Homo sapiens 3D-structure Acetylation Activator Alternative splicing Apoptosis Cell membrane Cell projection Chromatin regulator Cytoplasm DNA damage Membrane Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation MSVPSSLSQS MSVPSSLSQSAINANSHGGPALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGEGGGPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEPEMAPLGPKGLIHLYSELELSAHNAANRGLRGPGLIISTQEQGPDEGEEKAAGEAEEEEEDDDDEEEEEDLSSPPGLPEPLESVEAPPRPQALTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGSSPQEESQLTWTGFAHGEGFEDGEFWKDEPSDEAPMELGLKEPEEGTLTFPAQSLSPEPLPQEEEKLPPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP |
cellular response to virus lymphatic endothelial cell migration xenophagy | cytoplasm; cytoplasmic vesicle; cytosol; extracellular space; membrane | carbohydrate binding integrin binding | Homo sapiens | 3D-structure Alternative splicing Autophagy Cytoplasm Cytoplasmic vesicle Lectin Reference proteome Repeat | MMLSLNNLQN | MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW | cellular response to virus lymphatic endothelial cell migration xenophagy cytoplasm; cytoplasmic vesicle; cytosol; extracellular space; membrane carbohydrate binding integrin binding Homo sapiens 3D-structure Alternative splicing Autophagy Cytoplasm Cytoplasmic vesicle Lectin Reference proteome Repeat MMLSLNNLQN MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW |
carbohydrate metabolic process extracellular matrix assembly extracellular polysaccharide biosynthetic process hyaluronan biosynthetic process positive regulation of DNA-templated transcription positive regulation of hyaluranon cable assembly | early endosome; Golgi apparatus; Golgi membrane; hyaluranon cable; membrane; nucleus; plasma membrane | hyaluronan synthase activity identical protein binding | Homo sapiens | Alternative splicing Cell membrane Endosome Glycoprotein Glycosyltransferase Golgi apparatus Membrane Reference proteome Transferase Transmembrane Transmembrane helix | MPVQLTTALR | MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV | carbohydrate metabolic process extracellular matrix assembly extracellular polysaccharide biosynthetic process hyaluronan biosynthetic process positive regulation of DNA-templated transcription positive regulation of hyaluranon cable assembly early endosome; Golgi apparatus; Golgi membrane; hyaluranon cable; membrane; nucleus; plasma membrane hyaluronan synthase activity identical protein binding Homo sapiens Alternative splicing Cell membrane Endosome Glycoprotein Glycosyltransferase Golgi apparatus Membrane Reference proteome Transferase Transmembrane Transmembrane helix MPVQLTTALR MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV |
activation of NF-kappaB-inducing kinase activity apoptotic process cellular response to mechanical stimulus extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors positive regulation of apoptotic process signal transduction TRAIL-activated apoptotic signaling pathway | cell surface; cytosol; Golgi apparatus; membrane raft; plasma membrane | death receptor activity identical protein binding protease binding signaling receptor activity TRAIL binding | Homo sapiens | 3D-structure Apoptosis Cell membrane Cytoplasm Disulfide bond Glycoprotein Membrane Methylation Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix | MAPPPARVHL | MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE | activation of NF-kappaB-inducing kinase activity apoptotic process cellular response to mechanical stimulus extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway via death domain receptors positive regulation of apoptotic process signal transduction TRAIL-activated apoptotic signaling pathway cell surface; cytosol; Golgi apparatus; membrane raft; plasma membrane death receptor activity identical protein binding protease binding signaling receptor activity TRAIL binding Homo sapiens 3D-structure Apoptosis Cell membrane Cytoplasm Disulfide bond Glycoprotein Membrane Methylation Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix MAPPPARVHL MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE |
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled glutamate receptor signaling pathway regulation of synaptic transmission, glutamatergic visual perception | plasma membrane | G protein-coupled receptor activity glutamate receptor activity group III metabotropic glutamate receptor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Isopeptide bond Membrane Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Ubl conjugation | MVCEGKRSAS | MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI | adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled glutamate receptor signaling pathway regulation of synaptic transmission, glutamatergic visual perception plasma membrane G protein-coupled receptor activity glutamate receptor activity group III metabotropic glutamate receptor activity Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Isopeptide bond Membrane Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Ubl conjugation MVCEGKRSAS MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTYISYSNHSI |
proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process stem cell differentiation ubiquitin-dependent protein catabolic process | cytosol; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, lid subcomplex; secretory granule lumen | structural molecule activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteasome Reference proteome Ubl conjugation | MAAAAVVEFQ | MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT | proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process stem cell differentiation ubiquitin-dependent protein catabolic process cytosol; extracellular region; ficolin-1-rich granule lumen; membrane; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, lid subcomplex; secretory granule lumen structural molecule activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Proteasome Reference proteome Ubl conjugation MAAAAVVEFQ MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT |
negative regulation of insulin secretion positive regulation of DNA-templated transcription positive regulation of insulin secretion proteasome regulatory particle assembly ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; nucleoplasm; nucleus; proteasome regulatory particle | bHLH transcription factor binding transcription coactivator activity | Homo sapiens | Alternative splicing Chaperone Phosphoprotein Reference proteome | MSDEEARQSG | MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR | negative regulation of insulin secretion positive regulation of DNA-templated transcription positive regulation of insulin secretion proteasome regulatory particle assembly ubiquitin-dependent protein catabolic process cytoplasm; cytosol; nucleoplasm; nucleus; proteasome regulatory particle bHLH transcription factor binding transcription coactivator activity Homo sapiens Alternative splicing Chaperone Phosphoprotein Reference proteome MSDEEARQSG MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR |
central nervous system development protein ubiquitination ubiquitin-dependent ERAD pathway | endoplasmic reticulum; endoplasmic reticulum membrane | metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | Endoplasmic reticulum Membrane Metal-binding Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation pathway Zinc Zinc-finger | MWLKLFFLLL | MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYSGLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWLVQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQTSTSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLFANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYGNHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTLGTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALFLSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVESDWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNTNEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS | central nervous system development protein ubiquitination ubiquitin-dependent ERAD pathway endoplasmic reticulum; endoplasmic reticulum membrane metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Homo sapiens Endoplasmic reticulum Membrane Metal-binding Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation pathway Zinc Zinc-finger MWLKLFFLLL MWLKLFFLLLYFLVLFVLARFFEAIVWYETGIFATQLVDPVALSFKKLKTILECRGLGYSGLPEKKDVRELVEKSGDLMEGELYSALKEEEASESVSSTNFSGEMHFYELVEDTKDGIWLVQVIANDRSPLVGKIHWEKMVKKVSRFGIRTGTFNCSSDPRYCRRRGWVRSTLIMSVPQTSTSKGKVMLKEYSGRKIEVEHIFKWITAHAASRIKTIYNAEHLKEEWNKSDQYWLKIYLFANLDQPPAFFSALSIKFTGRVEFIFVNVENWDNKSYMTDIGIYNMPSYILRTPEGIYRYGNHTGEFISLQAMDSFLRSLQPEVNDLFVLSLVLVNLMAWMDLFITQGATIKRFVVLISTLGTYNSLLIISWLPVLGFLQLPYLDSFYEYSLKLLRYSNTTTLASWVRADWMFYSSHPALFLSTYLGHGLLIDYFEKKRRRNNNNDEVNANNLEWLSSLWDWYTSYLFHPIASFQNFPVESDWDEDPDLFLERLAFPDLWLHPLIPTDYIKNLPMWRFKCLGVQSEEEMSEGSQDTENDSESENTDTLSSEKEVFEDKQSVLHNSPGTASHCDAEACSCANKYCQTSPCERKGRSYGSYNTNEDMEPDWLTWPADMLHCTECVVCLENFENGCLLMGLPCGHVFHQNCIVMWLAGGRHCCPVCRWPSYKKKQPYAQHQPLSNDVPS |
BMP signaling pathway cartilage condensation cellular response to BMP stimulus cellular response to growth factor stimulus central nervous system neuron differentiation chondrocyte development dorsal/ventral pattern formation endochondral bone morphogenesis eye development inflammatory response negative regulation of chondrocyte proliferation osteoblast differentiation ovarian cumulus expansion ovulation cycle phosphorylation positive regulation of bone mineralization positive regulation of cartilage development positive regulation of chondrocyte differentiation positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II proteoglycan biosynthetic process retina development in camera-type eye retinal ganglion cell axon guidance | dendrite; HFE-transferrin receptor complex; neuronal cell body; plasma membrane; receptor complex | ATP binding BMP binding BMP receptor activity metal ion binding protein serine/threonine kinase activity SMAD binding transforming growth factor beta receptor activity, type I transmembrane receptor protein serine/threonine kinase activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell membrane Chondrogenesis Disease variant Disulfide bond Dwarfism Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix | MLLRSAGKLN | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL | BMP signaling pathway cartilage condensation cellular response to BMP stimulus cellular response to growth factor stimulus central nervous system neuron differentiation chondrocyte development dorsal/ventral pattern formation endochondral bone morphogenesis eye development inflammatory response negative regulation of chondrocyte proliferation osteoblast differentiation ovarian cumulus expansion ovulation cycle phosphorylation positive regulation of bone mineralization positive regulation of cartilage development positive regulation of chondrocyte differentiation positive regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II proteoglycan biosynthetic process retina development in camera-type eye retinal ganglion cell axon guidance dendrite; HFE-transferrin receptor complex; neuronal cell body; plasma membrane; receptor complex ATP binding BMP binding BMP receptor activity metal ion binding protein serine/threonine kinase activity SMAD binding transforming growth factor beta receptor activity, type I transmembrane receptor protein serine/threonine kinase activity transmembrane signaling receptor activity Homo sapiens 3D-structure Alternative splicing ATP-binding Cell membrane Chondrogenesis Disease variant Disulfide bond Dwarfism Kinase Magnesium Manganese Membrane Metal-binding Nucleotide-binding Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix MLLRSAGKLN MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL |
copper ion transport intracellular copper ion homeostasis response to oxidative stress | cytosol | copper chaperone activity copper ion binding copper-dependent protein binding cuprous ion binding metallochaperone activity | Homo sapiens | 3D-structure Acetylation Chaperone Copper Copper transport Ion transport Metal-binding Phosphoprotein Reference proteome Transport | MPKHEFSVDM | MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE | copper ion transport intracellular copper ion homeostasis response to oxidative stress cytosol copper chaperone activity copper ion binding copper-dependent protein binding cuprous ion binding metallochaperone activity Homo sapiens 3D-structure Acetylation Chaperone Copper Copper transport Ion transport Metal-binding Phosphoprotein Reference proteome Transport MPKHEFSVDM MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE |
adult feeding behavior circadian rhythm eating behavior feeding behavior hormone-mediated signaling pathway long-day photoperiodism maternal process involved in female pregnancy neuropeptide signaling pathway positive regulation of feeding behavior regulation of feeding behavior response to insulin | extracellular space; Golgi lumen; neuronal cell body | neuropeptide hormone activity signaling receptor binding type 1 melanocortin receptor binding | Homo sapiens | 3D-structure Disease variant Disulfide bond Golgi apparatus Knottin Obesity Reference proteome Secreted Signal | MLTAAVLSCA | MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT | adult feeding behavior circadian rhythm eating behavior feeding behavior hormone-mediated signaling pathway long-day photoperiodism maternal process involved in female pregnancy neuropeptide signaling pathway positive regulation of feeding behavior regulation of feeding behavior response to insulin extracellular space; Golgi lumen; neuronal cell body neuropeptide hormone activity signaling receptor binding type 1 melanocortin receptor binding Homo sapiens 3D-structure Disease variant Disulfide bond Golgi apparatus Knottin Obesity Reference proteome Secreted Signal MLTAAVLSCA MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT |
blood coagulation ligand-gated ion channel signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway platelet activation positive regulation of insulin secretion positive regulation of Rho protein signal transduction response to wounding | apical plasma membrane; extracellular region; plasma membrane; protein-containing complex | G protein-coupled receptor activity phosphatidylinositol phospholipase C activity receptor ligand activity thrombin-activated receptor activity | Homo sapiens | Alternative splicing Blood coagulation Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Hemostasis Membrane Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix | MKALIFAAAG | MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK | blood coagulation ligand-gated ion channel signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway platelet activation positive regulation of insulin secretion positive regulation of Rho protein signal transduction response to wounding apical plasma membrane; extracellular region; plasma membrane; protein-containing complex G protein-coupled receptor activity phosphatidylinositol phospholipase C activity receptor ligand activity thrombin-activated receptor activity Homo sapiens Alternative splicing Blood coagulation Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Hemostasis Membrane Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix MKALIFAAAG MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK |
DNA damage response DNA repair MAPK cascade negative regulation of cell cycle negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of JNK cascade negative regulation of osteoblast differentiation negative regulation of protein phosphorylation negative regulation of telomerase activity negative regulation of transcription by RNA polymerase II osteoblast development positive regulation of transcription by RNA polymerase II positive regulation of transforming growth factor beta receptor signaling pathway regulation of transcription by RNA polymerase II response to gamma radiation response to UV T-helper 2 cell differentiation transcription initiation-coupled chromatin remodeling | chromatin; chromosome, telomeric region; cleavage furrow; cytoplasm; cytosol; endoplasmic reticulum lumen; histone methyltransferase complex; MLL1 complex; MLL1/2 complex; nuclear matrix; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex | chromatin binding double-stranded DNA binding four-way junction DNA binding phosphoprotein binding protein-macromolecule adaptor activity R-SMAD binding transcription cis-regulatory region binding Y-form DNA binding | Homo sapiens | 3D-structure Alternative splicing Chromatin regulator Disease variant DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation | MGLKAAQKTL | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL | DNA damage response DNA repair MAPK cascade negative regulation of cell cycle negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of JNK cascade negative regulation of osteoblast differentiation negative regulation of protein phosphorylation negative regulation of telomerase activity negative regulation of transcription by RNA polymerase II osteoblast development positive regulation of transcription by RNA polymerase II positive regulation of transforming growth factor beta receptor signaling pathway regulation of transcription by RNA polymerase II response to gamma radiation response to UV T-helper 2 cell differentiation transcription initiation-coupled chromatin remodeling chromatin; chromosome, telomeric region; cleavage furrow; cytoplasm; cytosol; endoplasmic reticulum lumen; histone methyltransferase complex; MLL1 complex; MLL1/2 complex; nuclear matrix; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex chromatin binding double-stranded DNA binding four-way junction DNA binding phosphoprotein binding protein-macromolecule adaptor activity R-SMAD binding transcription cis-regulatory region binding Y-form DNA binding Homo sapiens 3D-structure Alternative splicing Chromatin regulator Disease variant DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation MGLKAAQKTL MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL |
chromatin organization negative regulation of apoptotic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II protein sumoylation | nuclear body; nuclear speck; nucleoplasm; nucleus; PcG protein complex; PRC1 complex | chromatin binding enzyme binding methylated histone binding phosphoprotein binding single-stranded RNA binding SUMO binding SUMO ligase activity SUMO transferase activity transcription cis-regulatory region binding transcription corepressor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Chromatin regulator Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway | MELPAVGEHV | MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV | chromatin organization negative regulation of apoptotic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II protein sumoylation nuclear body; nuclear speck; nucleoplasm; nucleus; PcG protein complex; PRC1 complex chromatin binding enzyme binding methylated histone binding phosphoprotein binding single-stranded RNA binding SUMO binding SUMO ligase activity SUMO transferase activity transcription cis-regulatory region binding transcription corepressor activity Homo sapiens 3D-structure Acetylation Alternative splicing Chromatin regulator Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway MELPAVGEHV MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV |
protein insertion into ER membrane protein stabilization tail-anchored membrane protein insertion into ER membrane | endoplasmic reticulum membrane; GET complex; nucleus | protein-membrane adaptor activity | Homo sapiens | 3D-structure Alternative splicing Coiled coil Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix | MSSAAADHWA | MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS | protein insertion into ER membrane protein stabilization tail-anchored membrane protein insertion into ER membrane endoplasmic reticulum membrane; GET complex; nucleus protein-membrane adaptor activity Homo sapiens 3D-structure Alternative splicing Coiled coil Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix MSSAAADHWA MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS |
associative learning axon guidance heme biosynthetic process memory modification of synaptic structure negative regulation of synapse organization positive regulation of lipoprotein transport positive regulation of protein localization to plasma membrane | cell body; endomembrane system; endoplasmic reticulum; extracellular region; membrane; mitochondrial outer membrane; neuron projection; neuronal cell body; plasma membrane; smooth endoplasmic reticulum membrane; specific granule membrane; synapse | amyloid-beta binding heme binding metal ion binding protein homodimerization activity steroid binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Endoplasmic reticulum Glycoprotein Iron Lipid-binding Membrane Metal-binding Microsome Mitochondrion Mitochondrion outer membrane Phosphoprotein Proteoglycan Receptor Reference proteome Secreted Steroid-binding Transmembrane Transmembrane helix | MAAEDVVATG | MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND | associative learning axon guidance heme biosynthetic process memory modification of synaptic structure negative regulation of synapse organization positive regulation of lipoprotein transport positive regulation of protein localization to plasma membrane cell body; endomembrane system; endoplasmic reticulum; extracellular region; membrane; mitochondrial outer membrane; neuron projection; neuronal cell body; plasma membrane; smooth endoplasmic reticulum membrane; specific granule membrane; synapse amyloid-beta binding heme binding metal ion binding protein homodimerization activity steroid binding Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Endoplasmic reticulum Glycoprotein Iron Lipid-binding Membrane Metal-binding Microsome Mitochondrion Mitochondrion outer membrane Phosphoprotein Proteoglycan Receptor Reference proteome Secreted Steroid-binding Transmembrane Transmembrane helix MAAEDVVATG MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND |
G protein-coupled receptor signaling pathway lipid metabolic process negative regulation of inflammatory response positive regulation of immune response response to acidic pH response to ischemia response to molecule of bacterial origin | plasma membrane | arachidonic acid binding bioactive lipid receptor activity G protein-coupled receptor activity | Homo sapiens | Cell membrane G-protein coupled receptor Glycoprotein Lipid metabolism Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MPFPNCSAPS | MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALHFLLDLSRSVGMAFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNSTRCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSVLNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS | G protein-coupled receptor signaling pathway lipid metabolic process negative regulation of inflammatory response positive regulation of immune response response to acidic pH response to ischemia response to molecule of bacterial origin plasma membrane arachidonic acid binding bioactive lipid receptor activity G protein-coupled receptor activity Homo sapiens Cell membrane G-protein coupled receptor Glycoprotein Lipid metabolism Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix MPFPNCSAPS MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALHFLLDLSRSVGMAFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNSTRCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSVLNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS |
apoptotic DNA fragmentation chaperone-mediated protein folding negative regulation of apoptotic DNA fragmentation negative regulation of deoxyribonuclease activity negative regulation of execution phase of apoptosis positive regulation of apoptotic process thymocyte apoptotic process | chromatin; cytosol; nucleoplasm; nucleus; plasma membrane; protein-containing complex | deoxyribonuclease inhibitor activity protein domain specific binding protein folding chaperone | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis Cytoplasm Direct protein sequencing Phosphoprotein Reference proteome | MEVTGDAGVP | MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT | apoptotic DNA fragmentation chaperone-mediated protein folding negative regulation of apoptotic DNA fragmentation negative regulation of deoxyribonuclease activity negative regulation of execution phase of apoptosis positive regulation of apoptotic process thymocyte apoptotic process chromatin; cytosol; nucleoplasm; nucleus; plasma membrane; protein-containing complex deoxyribonuclease inhibitor activity protein domain specific binding protein folding chaperone Homo sapiens 3D-structure Acetylation Alternative splicing Apoptosis Cytoplasm Direct protein sequencing Phosphoprotein Reference proteome MEVTGDAGVP MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDILAIDKSLTPVTLVLAEDGTIVDDDDYFLCLPSNTKFVALASNEKWAYNNSDGGTAWISQESFDVDETDSGAGLKWKNVARQLKEDLSSIILLSEEDLQMLVDAPCSDLAQELRQSCATVQRLQHTLQQVLDQREEVRQSKQLLQLYLQALEKEGSLLSKQEESKAAFGEEVDAVDTGISRETSSDVALASHILTALREKQAPELSLSSQDLELVTKEDPKALAVALNWDIKKTETVQEACERELALRLQQTQSLHSLRSISASKASPPGDLQNPKRARQDPT |
positive regulation of MHC class II biosynthetic process positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | nuclear speck; nucleus; RNA polymerase II transcription regulator complex | DNA binding | Homo sapiens | 3D-structure Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome SCID Ubl conjugation | MEAQGVAEGA | MEAQGVAEGAGPGAASGVPHPAALAPAAAPTLAPASVAAAASQFTLLVMQPCAGQDEAAAPGGSVGAGKPVRYLCEGAGDGEEEAGEDEADLLDTSDPPGGGESAASLEDLEDEETHSGGEGSSGGARRRGSGGGSMSKTCTYEGCSETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALNCGGTASTGSAGNVKLEESADNILSIVKQRTGSFGDRPARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFPGTSM | positive regulation of MHC class II biosynthetic process positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II nuclear speck; nucleus; RNA polymerase II transcription regulator complex DNA binding Homo sapiens 3D-structure Direct protein sequencing DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome SCID Ubl conjugation MEAQGVAEGA MEAQGVAEGAGPGAASGVPHPAALAPAAAPTLAPASVAAAASQFTLLVMQPCAGQDEAAAPGGSVGAGKPVRYLCEGAGDGEEEAGEDEADLLDTSDPPGGGESAASLEDLEDEETHSGGEGSSGGARRRGSGGGSMSKTCTYEGCSETTSQVAKQRKPWMCKKHRNKMYKDKYKKKKSDQALNCGGTASTGSAGNVKLEESADNILSIVKQRTGSFGDRPARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFPGTSM |
anterior/posterior axis specification | collagen-containing extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen | cytokine activity growth factor activity transforming growth factor beta receptor binding | Homo sapiens | Alternative splicing Cytokine Developmental protein Disease variant Disulfide bond Glycoprotein Growth factor Heterotaxy Reference proteome Secreted Signal | MWPLWLCWAL | MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP | anterior/posterior axis specification collagen-containing extracellular matrix; extracellular region; extracellular space; platelet alpha granule lumen cytokine activity growth factor activity transforming growth factor beta receptor binding Homo sapiens Alternative splicing Cytokine Developmental protein Disease variant Disulfide bond Glycoprotein Growth factor Heterotaxy Reference proteome Secreted Signal MWPLWLCWAL MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP |
dendrite development detection of light stimulus involved in visual perception eye photoreceptor cell development phagocytosis, recognition photoreceptor cell maintenance positive regulation of phagocytosis protein localization to cilium protein localization to photoreceptor outer segment retina development in camera-type eye retina homeostasis visual perception | axon terminus; cell projection; cilium; cytosol; extracellular region; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; synapse | actin filament binding phosphatidylinositol-4,5-bisphosphate binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cytoplasm Disease variant Leber congenital amaurosis Membrane Phagocytosis Reference proteome Retinitis pigmentosa Secreted Sensory transduction Synapse Vision | MPLRDETLRE | MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE | dendrite development detection of light stimulus involved in visual perception eye photoreceptor cell development phagocytosis, recognition photoreceptor cell maintenance positive regulation of phagocytosis protein localization to cilium protein localization to photoreceptor outer segment retina development in camera-type eye retina homeostasis visual perception axon terminus; cell projection; cilium; cytosol; extracellular region; photoreceptor inner segment; photoreceptor outer segment; plasma membrane; synapse actin filament binding phosphatidylinositol-4,5-bisphosphate binding Homo sapiens 3D-structure Alternative splicing Cell membrane Cytoplasm Disease variant Leber congenital amaurosis Membrane Phagocytosis Reference proteome Retinitis pigmentosa Secreted Sensory transduction Synapse Vision MPLRDETLRE MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE |
chloride transport platelet aggregation positive regulation of osteoblast differentiation regulation of mitochondrial membrane potential signal transduction | blood microparticle; brush border; chloride channel complex; cytoplasm; endoplasmic reticulum; extracellular exosome; extracellular space; membrane; mitochondrion; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; vesicle | cadherin binding chloride channel activity | Homo sapiens | 3D-structure Acetylation Cell membrane Chloride Chloride channel Cytoplasm Direct protein sequencing Disulfide bond Endoplasmic reticulum Glutathionylation Ion channel Ion transport Membrane Nucleus Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel | MAEEQPQVEL | MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK | chloride transport platelet aggregation positive regulation of osteoblast differentiation regulation of mitochondrial membrane potential signal transduction blood microparticle; brush border; chloride channel complex; cytoplasm; endoplasmic reticulum; extracellular exosome; extracellular space; membrane; mitochondrion; nuclear envelope; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; vesicle cadherin binding chloride channel activity Homo sapiens 3D-structure Acetylation Cell membrane Chloride Chloride channel Cytoplasm Direct protein sequencing Disulfide bond Endoplasmic reticulum Glutathionylation Ion channel Ion transport Membrane Nucleus Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel MAEEQPQVEL MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK |
apoptotic process extracellular matrix organization negative regulation of bone resorption negative regulation of odontogenesis of dentin-containing tooth negative regulation of osteoclast differentiation response to arsenic-containing substance response to estrogen response to magnesium ion response to nutrient response to xenobiotic stimulus signal transduction skeletal system development | extracellular matrix; extracellular region; extracellular space; plasma membrane; receptor complex | cytokine activity signaling receptor activity | Homo sapiens | 3D-structure Apoptosis Direct protein sequencing Disease variant Disulfide bond Glycoprotein Receptor Reference proteome Repeat Secreted Signal | MNNLLCCALV | MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL | apoptotic process extracellular matrix organization negative regulation of bone resorption negative regulation of odontogenesis of dentin-containing tooth negative regulation of osteoclast differentiation response to arsenic-containing substance response to estrogen response to magnesium ion response to nutrient response to xenobiotic stimulus signal transduction skeletal system development extracellular matrix; extracellular region; extracellular space; plasma membrane; receptor complex cytokine activity signaling receptor activity Homo sapiens 3D-structure Apoptosis Direct protein sequencing Disease variant Disulfide bond Glycoprotein Receptor Reference proteome Repeat Secreted Signal MNNLLCCALV MNNLLCCALVFLDISIKWTTQETFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQKCGIDVTLCEEAFFRFAVPTKFTPNWLSVLVDNLPGTKVNAESVERIKRQHSSQEQTFQLLKLWKHQNKDQDIVKKIIQDIDLCENSVQRHIGHANLTFEQLRSLMESLPGKKVGAEDIEKTIKACKPSDQILKLLSLWRIKNGDQDTLKGLMHALKHSKTYHFPKTVTQSLKKTIRFLHSFTMYKLYQKLFLEMIGNQVQSVKISCL |
formation of cytoplasmic translation initiation complex IRES-dependent viral translational initiation protein deubiquitination proteolysis translational initiation | cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; membrane; synapse | cysteine-type deubiquitinase activity identical protein binding metal-dependent deubiquitinase activity translation initiation factor activity translation initiation factor binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Disease variant Hydrolase Initiation factor Intellectual disability Phosphoprotein Protease Protein biosynthesis Reference proteome Thiol protease Ubl conjugation pathway | MATPAVPVSA | MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPGQTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL | formation of cytoplasmic translation initiation complex IRES-dependent viral translational initiation protein deubiquitination proteolysis translational initiation cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3m; membrane; synapse cysteine-type deubiquitinase activity identical protein binding metal-dependent deubiquitinase activity translation initiation factor activity translation initiation factor binding Homo sapiens 3D-structure Acetylation Cytoplasm Disease variant Hydrolase Initiation factor Intellectual disability Phosphoprotein Protease Protein biosynthesis Reference proteome Thiol protease Ubl conjugation pathway MATPAVPVSA MATPAVPVSAPPATPTPVPAAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPGQTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL |
adult walking behavior cAMP metabolic process cellular response to leukemia inhibitory factor chemical synaptic transmission detection of light stimulus involved in visual perception gamma-aminobutyric acid secretion gamma-aminobutyric acid signaling pathway muscle cell development negative regulation of cell population proliferation negative regulation of G1/S transition of mitotic cell cycle neuromuscular junction development neuronal action potential propagation Peyer's patch development positive regulation of protein localization to nucleolus regulation of synaptic vesicle exocytosis regulation of voltage-gated calcium channel activity spleen development synaptic transmission, glutamatergic T cell receptor signaling pathway thymus development | cytoplasmic side of plasma membrane; cytosol; glutamatergic synapse; nuclear speck; plasma membrane; presynapse; synapse; voltage-gated calcium channel complex | protein kinase binding voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels | Homo sapiens | 3D-structure Alternative splicing Calcium Calcium channel Calcium transport Disease variant Epilepsy Ion channel Ion transport Methylation Phosphoprotein Reference proteome SH3 domain Transport Voltage-gated channel | MSSSSYAKNG | MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL | adult walking behavior cAMP metabolic process cellular response to leukemia inhibitory factor chemical synaptic transmission detection of light stimulus involved in visual perception gamma-aminobutyric acid secretion gamma-aminobutyric acid signaling pathway muscle cell development negative regulation of cell population proliferation negative regulation of G1/S transition of mitotic cell cycle neuromuscular junction development neuronal action potential propagation Peyer's patch development positive regulation of protein localization to nucleolus regulation of synaptic vesicle exocytosis regulation of voltage-gated calcium channel activity spleen development synaptic transmission, glutamatergic T cell receptor signaling pathway thymus development cytoplasmic side of plasma membrane; cytosol; glutamatergic synapse; nuclear speck; plasma membrane; presynapse; synapse; voltage-gated calcium channel complex protein kinase binding voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Homo sapiens 3D-structure Alternative splicing Calcium Calcium channel Calcium transport Disease variant Epilepsy Ion channel Ion transport Methylation Phosphoprotein Reference proteome SH3 domain Transport Voltage-gated channel MSSSSYAKNG MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPMTPLLGRNLGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGYSHDSRHRL |
extracellular transport negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of gene expression negative regulation of Notch signaling pathway negative regulation of protein transport negative regulation of transcription by RNA polymerase II negative regulation of transporter activity positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination protein K63-linked ubiquitination protein modification process protein ubiquitination regulation of membrane potential regulation of monoatomic ion transmembrane transport regulation of potassium ion transmembrane transporter activity transcription by RNA polymerase II viral entry into host cell | cytoplasm; cytosol; extracellular exosome; membrane; nucleus; ubiquitin ligase complex | RNA polymerase II-specific DNA-binding transcription factor binding transcription factor binding ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | 3D-structure Alternative splicing Host-virus interaction Nucleus Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway | MASASSSRAG | MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE | extracellular transport negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of gene expression negative regulation of Notch signaling pathway negative regulation of protein transport negative regulation of transcription by RNA polymerase II negative regulation of transporter activity positive regulation of transcription by RNA polymerase II proteasome-mediated ubiquitin-dependent protein catabolic process protein autoubiquitination protein K63-linked ubiquitination protein modification process protein ubiquitination regulation of membrane potential regulation of monoatomic ion transmembrane transport regulation of potassium ion transmembrane transporter activity transcription by RNA polymerase II viral entry into host cell cytoplasm; cytosol; extracellular exosome; membrane; nucleus; ubiquitin ligase complex RNA polymerase II-specific DNA-binding transcription factor binding transcription factor binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Homo sapiens 3D-structure Alternative splicing Host-virus interaction Nucleus Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway MASASSSRAG MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE |
cell cycle phase transition cell division double-strand break repair via break-induced replication G1/S transition of mitotic cell cycle phosphorylation positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle positive regulation of nuclear cell cycle DNA replication signal transduction | cytoplasm; intercellular bridge; mitotic spindle; nucleoplasm; nucleus | ATP binding kinase activity metal ion binding protein kinase activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell cycle Cell division Isopeptide bond Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MEASLGIQMD | MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL | cell cycle phase transition cell division double-strand break repair via break-induced replication G1/S transition of mitotic cell cycle phosphorylation positive regulation of cell population proliferation positive regulation of G2/M transition of mitotic cell cycle positive regulation of nuclear cell cycle DNA replication signal transduction cytoplasm; intercellular bridge; mitotic spindle; nucleoplasm; nucleus ATP binding kinase activity metal ion binding protein kinase activity protein serine kinase activity protein serine/threonine kinase activity Homo sapiens 3D-structure Alternative splicing ATP-binding Cell cycle Cell division Isopeptide bond Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation MEASLGIQMD MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL |
acetyl-CoA biosynthetic process from pyruvate | mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; pyruvate dehydrogenase complex | acyltransferase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Lipoyl Mitochondrion Phosphoprotein Reference proteome Transit peptide | MAASWRLGCD | MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIRLA | acetyl-CoA biosynthetic process from pyruvate mitochondrial matrix; mitochondrial pyruvate dehydrogenase complex; mitochondrion; pyruvate dehydrogenase complex acyltransferase activity Homo sapiens 3D-structure Acetylation Alternative splicing Lipoyl Mitochondrion Phosphoprotein Reference proteome Transit peptide MAASWRLGCD MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKILMPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSKNIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTLRFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTATPTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPHAYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPFIDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNLGMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDDELATRFLKSFKANLENPIRLA |
azole transmembrane transport cytidine transport nucleoside import across plasma membrane nucleoside transmembrane transport purine nucleobase transmembrane transport pyrimidine nucleobase transport pyrimidine-containing compound transmembrane transport uridine transport | apical plasma membrane; brush border membrane; cytosol; nuclear speck; plasma membrane | azole transmembrane transporter activity cytidine transmembrane transporter activity nucleoside:sodium symporter activity purine nucleobase transmembrane transporter activity pyrimidine- and adenosine-specific:sodium symporter activity uridine transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Disease variant Glycoprotein Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport | MENDPSRRRE | MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ | azole transmembrane transport cytidine transport nucleoside import across plasma membrane nucleoside transmembrane transport purine nucleobase transmembrane transport pyrimidine nucleobase transport pyrimidine-containing compound transmembrane transport uridine transport apical plasma membrane; brush border membrane; cytosol; nuclear speck; plasma membrane azole transmembrane transporter activity cytidine transmembrane transporter activity nucleoside:sodium symporter activity purine nucleobase transmembrane transporter activity pyrimidine- and adenosine-specific:sodium symporter activity uridine transmembrane transporter activity Homo sapiens Alternative splicing Cell membrane Disease variant Glycoprotein Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport MENDPSRRRE MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ |
amine metabolic process sulfation | cytoplasm; cytosol; lysosome | aryl sulfotransferase activity sulfotransferase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Lysosome Phosphoprotein Reference proteome Transferase | MALTSDLGKQ | MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL | amine metabolic process sulfation cytoplasm; cytosol; lysosome aryl sulfotransferase activity sulfotransferase activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Lysosome Phosphoprotein Reference proteome Transferase MALTSDLGKQ MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL |
axon guidance dendrite regeneration extracellular matrix organization glial cell migration neuron migration response to axon injury | basement membrane; collagen-containing extracellular matrix; extracellular matrix; extracellular region; matrilin complex | calcium ion binding extracellular matrix structural constituent | Homo sapiens | Alternative splicing Coiled coil Disulfide bond EGF-like domain Glycoprotein Reference proteome Repeat Secreted Signal | MEKMLAGCFL | MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR | axon guidance dendrite regeneration extracellular matrix organization glial cell migration neuron migration response to axon injury basement membrane; collagen-containing extracellular matrix; extracellular matrix; extracellular region; matrilin complex calcium ion binding extracellular matrix structural constituent Homo sapiens Alternative splicing Coiled coil Disulfide bond EGF-like domain Glycoprotein Reference proteome Repeat Secreted Signal MEKMLAGCFL MEKMLAGCFLLILGQIVLLPAEARERSRGRSISRGRHARTHPQTALLESSCENKRADLVFIIDSSRSVNTHDYAKVKEFIVDILQFLDIGPDVTRVGLLQYGSTVKNEFSLKTFKRKSEVERAVKRMRHLSTGTMTGLAIQYALNIAFSEAEGARPLRENVPRVIMIVTDGRPQDSVAEVAAKARDTGILIFAIGVGQVDFNTLKSIGSEPHEDHVFLVANFSQIETLTSVFQKKLCTAHMCSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGIIDSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMFERSFTQGEGARPLSTRVPRAAIVFTDGRAQDDVSEWASKAKANGITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDFSTMDEISEKLKKGICEALEDSDGRQDSPAGELPKTVQQPTESEPVTINIQDLLSCSNFAVQHRYLFEEDNLLRSTQKLSHSTKPSGSPLEEKHDQCKCENLIMFQNLANEEVRKLTQRLEEMTQRMEALENRLRYR |
chloride transmembrane transport dicarboxylic acid transport L-glutamate transmembrane transport monoatomic ion transport neurotransmitter transport neurotransmitter uptake | plasma membrane; postsynapse; synaptic membrane | extracellularly glutamate-gated chloride channel activity glutamate:sodium symporter activity high-affinity L-glutamate transmembrane transporter activity L-glutamate transmembrane transporter activity neutral L-amino acid transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Glycoprotein Membrane Reference proteome Symport Synapse Transmembrane Transmembrane helix Transport | MVPHAILARG | MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEELPAASLNHCTIQISELETNV | chloride transmembrane transport dicarboxylic acid transport L-glutamate transmembrane transport monoatomic ion transport neurotransmitter transport neurotransmitter uptake plasma membrane; postsynapse; synaptic membrane extracellularly glutamate-gated chloride channel activity glutamate:sodium symporter activity high-affinity L-glutamate transmembrane transporter activity L-glutamate transmembrane transporter activity neutral L-amino acid transmembrane transporter activity Homo sapiens Alternative splicing Cell membrane Glycoprotein Membrane Reference proteome Symport Synapse Transmembrane Transmembrane helix Transport MVPHAILARG MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEELPAASLNHCTIQISELETNV |
anatomical structure morphogenesis cell differentiation cell migration chordate pharynx development cranial skeletal system development embryonic organ morphogenesis hair follicle morphogenesis hard palate development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription regulation of transcription by RNA polymerase II soft palate development thymus development thyroid gland development thyroid hormone generation | chromatin; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Congenital hypothyroidism Disease variant DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MTAESGPPPP | MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM | anatomical structure morphogenesis cell differentiation cell migration chordate pharynx development cranial skeletal system development embryonic organ morphogenesis hair follicle morphogenesis hard palate development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription regulation of transcription by RNA polymerase II soft palate development thymus development thyroid gland development thyroid hormone generation chromatin; nucleus DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Congenital hypothyroidism Disease variant DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MTAESGPPPP MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM |
extracellular matrix assembly negative regulation of macroautophagy protein folding | endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; intercellular bridge; intracellular membrane-bounded organelle; platelet alpha granule lumen; specific granule lumen; tertiary granule lumen | FAD binding flavin-dependent sulfhydryl oxidase activity protein disulfide isomerase activity | Homo sapiens | 3D-structure Alternative splicing Disulfide bond FAD Flavoprotein Glycoprotein Golgi apparatus Membrane Oxidoreductase Phosphoprotein Reference proteome Secreted Signal Transmembrane Transmembrane helix | MRRCNSGSGP | MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKGHAGHPAA | extracellular matrix assembly negative regulation of macroautophagy protein folding endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; intercellular bridge; intracellular membrane-bounded organelle; platelet alpha granule lumen; specific granule lumen; tertiary granule lumen FAD binding flavin-dependent sulfhydryl oxidase activity protein disulfide isomerase activity Homo sapiens 3D-structure Alternative splicing Disulfide bond FAD Flavoprotein Glycoprotein Golgi apparatus Membrane Oxidoreductase Phosphoprotein Reference proteome Secreted Signal Transmembrane Transmembrane helix MRRCNSGSGP MRRCNSGSGPPPSLLLLLLWLLAVPGANAAPRSALYSPSDPLTLLQADTVRGAVLGSRSAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPACPPLEPAKLEEIDGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVAVRRVLNTEANVVRKFGVTDFPSCYLLFRNGSVSRVPVLMESRSFYTAYLQRLSGLTREAAQTTVAPTTANKIAPTVWKLADRSKIYMADLESALHYILRIEVGRFPVLEGQRLVALKKFVAVLAKYFPGRPLVQNFLHSVNEWLKRQKRNKIPYSFFKTALDDRKEGAVLAKKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAARQNVDHSQEAAKAKEVLPAIRGYVHYFFGCRDCASHFEQMAAASMHRVGSPNAAVLWLWSSHNRVNARLAGAPSEDPQFPKVQWPPRELCSACHNERLDVPVWDVEATLNFLKAHFSPSNIILDFPAAGSAARRDVQNVAAAPELAMGALELESRNSTLDPGKPEMMKSPTNTTPHVPAEGPEASRPPKLHPGLRAAPGQEPPEHMAELQRNEQEQPLGQWHLSKRDTGAALLAESRAEKNRLWGPLEVRRVGRSSKQLVDIPEGQLEARAGRGRGQWLQVLGGGFSYLDISLCVGLYSLSFMGLLAMYTYFQAKIRALKGHAGHPAA |
mitotic spindle organization | centrosome; cytosol; dynactin complex; kinetochore | dynein complex binding | Homo sapiens | 3D-structure Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Phosphoprotein Reference proteome | MAEKTQKSVK | MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN | mitotic spindle organization centrosome; cytosol; dynactin complex; kinetochore dynein complex binding Homo sapiens 3D-structure Centromere Chromosome Cytoplasm Cytoskeleton Kinetochore Phosphoprotein Reference proteome MAEKTQKSVK MAEKTQKSVKIAPGAVVCVESEIRGDVTIGPRTVIHPKARIIAEAGPIVIGEGNLIEEQALIINAYPDNITPDTEDPEPKPMIIGTNNVFEVGCYSQAMKMGDNNVIESKAYVGRNVILTSGCIIGACCNLNTFEVIPENTVIYGADCLRRVQTERPQPQTLQLDFLMKILPNYHHLKKTMKGSSTPVKN |
acetyl-CoA transmembrane transport transmembrane transport | endoplasmic reticulum membrane; Golgi membrane; membrane; plasma membrane | acetyl-CoA transmembrane transporter activity protein homodimerization activity | Homo sapiens | Cataract Deafness Disease variant Endoplasmic reticulum Glycoprotein Hereditary spastic paraplegia Membrane Neurodegeneration Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MSPTISHKDS | MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN | acetyl-CoA transmembrane transport transmembrane transport endoplasmic reticulum membrane; Golgi membrane; membrane; plasma membrane acetyl-CoA transmembrane transporter activity protein homodimerization activity Homo sapiens Cataract Deafness Disease variant Endoplasmic reticulum Glycoprotein Hereditary spastic paraplegia Membrane Neurodegeneration Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport MSPTISHKDS MSPTISHKDSSRQRRPGNFSHSLDMKSGPLPPGGWDDSHLDSAGREGDREALLGDTGTGDFLKAPQSFRAELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYVKNFGRRKSWLVPTQYILGLFMIYLSTQVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQGITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLNTFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPIYYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAVELCKKLGGSCVTALDGYYVESIICVFIGFGWWFFLGPKFKKLQDEGSSSWKCKRNN |
actin filament polymerization actin polymerization or depolymerization cell division dendritic spine morphogenesis negative regulation of lymphocyte migration negative regulation of membrane tubulation positive regulation of clathrin-dependent endocytosis positive regulation of filopodium assembly positive regulation of transcription by RNA polymerase II protein-containing complex assembly protein-containing complex localization regulation of postsynapse organization regulation of protein localization response to bacterium spindle localization vesicle budding from membrane vesicle organization vesicle transport along actin filament | actin cap; actin cytoskeleton; cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; endoplasmic reticulum membrane; extracellular exosome; glutamatergic synapse; lamellipodium; nucleus; plasma membrane | actin binding GTPase regulator activity microtubule binding | Homo sapiens | 3D-structure Acetylation Actin-binding Cell cycle Cell division Cytoplasm Cytoskeleton Methylation Mitosis Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation | MSSVQQQPPP | MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED | actin filament polymerization actin polymerization or depolymerization cell division dendritic spine morphogenesis negative regulation of lymphocyte migration negative regulation of membrane tubulation positive regulation of clathrin-dependent endocytosis positive regulation of filopodium assembly positive regulation of transcription by RNA polymerase II protein-containing complex assembly protein-containing complex localization regulation of postsynapse organization regulation of protein localization response to bacterium spindle localization vesicle budding from membrane vesicle organization vesicle transport along actin filament actin cap; actin cytoskeleton; cytoplasm; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; endoplasmic reticulum membrane; extracellular exosome; glutamatergic synapse; lamellipodium; nucleus; plasma membrane actin binding GTPase regulator activity microtubule binding Homo sapiens 3D-structure Acetylation Actin-binding Cell cycle Cell division Cytoplasm Cytoskeleton Methylation Mitosis Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation MSSVQQQPPP MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED |
craniofacial suture morphogenesis mitotic G2 DNA damage checkpoint signaling negative regulation of DNA-templated transcription regulation of DNA-templated transcription | chromatin; nucleus | cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific | Homo sapiens | 3D-structure Alternative splicing Cell cycle DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation | MGPVMPPSKK | MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN | craniofacial suture morphogenesis mitotic G2 DNA damage checkpoint signaling negative regulation of DNA-templated transcription regulation of DNA-templated transcription chromatin; nucleus cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Homo sapiens 3D-structure Alternative splicing Cell cycle DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation MGPVMPPSKK MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN |
cellular response to anoxia cellular response to brain-derived neurotrophic factor stimulus cellular response to calcium ion cellular response to cAMP cellular response to insulin stimulus myosin II filament disassembly negative regulation of apoptotic process positive regulation of dendritic spine morphogenesis positive regulation of endocytosis positive regulation of synapse assembly protein autophosphorylation regulation of protein autophosphorylation regulation of translation at postsynapse response to ischemia response to prolactin translational elongation | cytoplasm; cytosol; dendritic spine; glutamatergic synapse; postsynaptic density | ATP binding calcium ion binding calmodulin binding elongation factor-2 kinase activity protein kinase activity translation factor activity, RNA binding | Homo sapiens | 3D-structure Acetylation ATP-binding Calcium Calmodulin-binding Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MADEDLIFRL | MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE | cellular response to anoxia cellular response to brain-derived neurotrophic factor stimulus cellular response to calcium ion cellular response to cAMP cellular response to insulin stimulus myosin II filament disassembly negative regulation of apoptotic process positive regulation of dendritic spine morphogenesis positive regulation of endocytosis positive regulation of synapse assembly protein autophosphorylation regulation of protein autophosphorylation regulation of translation at postsynapse response to ischemia response to prolactin translational elongation cytoplasm; cytosol; dendritic spine; glutamatergic synapse; postsynaptic density ATP binding calcium ion binding calmodulin binding elongation factor-2 kinase activity protein kinase activity translation factor activity, RNA binding Homo sapiens 3D-structure Acetylation ATP-binding Calcium Calmodulin-binding Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase MADEDLIFRL MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE |
calcium-mediated signaling cell chemotaxis chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response positive regulation of cytosolic calcium ion concentration | cytoplasm; external side of plasma membrane; plasma membrane | C-C chemokine binding C-C chemokine receptor activity CCR chemokine receptor binding chemokine receptor activity chemokine receptor binding | Homo sapiens | Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MANYTLAPED | MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV | calcium-mediated signaling cell chemotaxis chemotaxis G protein-coupled receptor signaling pathway immune response inflammatory response positive regulation of cytosolic calcium ion concentration cytoplasm; external side of plasma membrane; plasma membrane C-C chemokine binding C-C chemokine receptor activity CCR chemokine receptor binding chemokine receptor activity chemokine receptor binding Homo sapiens Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Receptor Reference proteome Transducer Transmembrane Transmembrane helix MANYTLAPED MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV |
mRNA processing negative regulation of DNA-templated transcription negative regulation of mRNA splicing, via spliceosome positive regulation of apoptotic process regulation of alternative mRNA splicing, via spliceosome regulation of transcription by RNA polymerase II RNA splicing | ASAP complex; cytosol; histone deacetylase complex; nuclear body; nuclear speck; nucleoplasm; nucleus | RNA binding transcription corepressor activity | Homo sapiens | 3D-structure Acetylation Alternative initiation Cytoplasm Isopeptide bond mRNA processing mRNA splicing Nucleus Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MAVESRVTQE | MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY | mRNA processing negative regulation of DNA-templated transcription negative regulation of mRNA splicing, via spliceosome positive regulation of apoptotic process regulation of alternative mRNA splicing, via spliceosome regulation of transcription by RNA polymerase II RNA splicing ASAP complex; cytosol; histone deacetylase complex; nuclear body; nuclear speck; nucleoplasm; nucleus RNA binding transcription corepressor activity Homo sapiens 3D-structure Acetylation Alternative initiation Cytoplasm Isopeptide bond mRNA processing mRNA splicing Nucleus Reference proteome Repressor Transcription Transcription regulation Ubl conjugation MAVESRVTQE MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY |
brain development hematopoietic progenitor cell differentiation microtubule cytoskeleton organization mitotic spindle organization neuroblast proliferation | cytosol; microtubule; microtubule associated complex; mitotic spindle midzone; mitotic spindle pole; perinuclear region of cytoplasm | calcium ion binding microtubule binding tubulin binding | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Epilepsy Intellectual disability Lissencephaly Microtubule Phosphoprotein Reference proteome Repeat WD repeat | MEDGFSSYSS | MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI | brain development hematopoietic progenitor cell differentiation microtubule cytoskeleton organization mitotic spindle organization neuroblast proliferation cytosol; microtubule; microtubule associated complex; mitotic spindle midzone; mitotic spindle pole; perinuclear region of cytoplasm calcium ion binding microtubule binding tubulin binding Homo sapiens 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Disease variant Epilepsy Intellectual disability Lissencephaly Microtubule Phosphoprotein Reference proteome Repeat WD repeat MEDGFSSYSS MEDGFSSYSSLYDTSSLLQFCNDDSASAASSMEVTDRIASLEQRVQMQEDDIQLLKSALADVVRRLNITEEQQAVLNRKGPTKARPLMQTLPLRTTVNNGTVLPKKPTGSLPSPSGVRKETAVPATKSNIKRTSSSERVSPGGRRESNGDSRGNRNRTGSTSSSSSGKKNSESKPKEPVFSAEEGYVKMFLRGRPVTMYMPKDQVDSYSLEAKVELPTKRLKLEWVYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVTCIAFSKSNGGTNLCAVDDSNDHVLSVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGKSHLYFWTLEGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNRISYAVQGAHEGGIFALCMLRDGTLVSGGGKDRKLISWSGNYQKLRKTEIPEQFGPIRTVAEGKGDVILIGTTRNFVLQGTLSGDFTPITQGHTDELWGLAIHASKSQFLTCGHDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYSPDGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHLDWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTCTLGFHVFGVWPEGSDGTDINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHIYGGHSSHVTNVDFLCEDSHLISTGGKDTSIMQWRVI |
anatomical structure morphogenesis CRD-mediated mRNA stabilization mRNA transport negative regulation of translation nervous system development regulation of cytokine production regulation of gene expression translation | cytoplasm; cytoplasmic stress granule; cytosol; nucleus; P-body | mRNA 3'-UTR binding mRNA 5'-UTR binding N6-methyladenosine-containing RNA reader activity RNA binding translation regulator activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Isopeptide bond mRNA transport Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Translation regulation Transport Ubl conjugation | MNKLYIGNLS | MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK | anatomical structure morphogenesis CRD-mediated mRNA stabilization mRNA transport negative regulation of translation nervous system development regulation of cytokine production regulation of gene expression translation cytoplasm; cytoplasmic stress granule; cytosol; nucleus; P-body mRNA 3'-UTR binding mRNA 5'-UTR binding N6-methyladenosine-containing RNA reader activity RNA binding translation regulator activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Isopeptide bond mRNA transport Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Translation regulation Transport Ubl conjugation MNKLYIGNLS MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK |
calcium ion transport endocytosis heart contraction intracellular distribution of mitochondria localization membrane fusion mitochondrial fission mitochondrial fragmentation involved in apoptotic process mitochondrial membrane fission mitochondrion organization mitocytosis necroptotic process peroxisome fission positive regulation of apoptotic process positive regulation of intrinsic apoptotic signaling pathway positive regulation of mitochondrial fission positive regulation of neutrophil chemotaxis positive regulation of protein secretion positive regulation of release of cytochrome c from mitochondria protein complex oligomerization protein localization to mitochondrion protein-containing complex assembly regulation of ATP metabolic process regulation of gene expression regulation of mitochondrion organization regulation of mitophagy regulation of peroxisome organization release of cytochrome c from mitochondria rhythmic process | brush border; clathrin-coated pit; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; microtubule; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein-containing complex; synaptic vesicle membrane | GTP binding GTP-dependent protein binding GTPase activator activity GTPase activity identical protein binding lipid binding microtubule binding molecular adaptor activity protein homodimerization activity small GTPase binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Biological rhythms Coated pit Cytoplasm Cytoplasmic vesicle Disease variant Endocytosis Glycoprotein Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipid-binding Membrane Mitochondrion Mitochondrion outer membrane Necrosis Nucleotide-binding Peroxisome Phosphoprotein Reference proteome S-nitrosylation Synapse Ubl conjugation | MEALIPVINK | MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW | calcium ion transport endocytosis heart contraction intracellular distribution of mitochondria localization membrane fusion mitochondrial fission mitochondrial fragmentation involved in apoptotic process mitochondrial membrane fission mitochondrion organization mitocytosis necroptotic process peroxisome fission positive regulation of apoptotic process positive regulation of intrinsic apoptotic signaling pathway positive regulation of mitochondrial fission positive regulation of neutrophil chemotaxis positive regulation of protein secretion positive regulation of release of cytochrome c from mitochondria protein complex oligomerization protein localization to mitochondrion protein-containing complex assembly regulation of ATP metabolic process regulation of gene expression regulation of mitochondrion organization regulation of mitophagy regulation of peroxisome organization release of cytochrome c from mitochondria rhythmic process brush border; clathrin-coated pit; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; microtubule; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein-containing complex; synaptic vesicle membrane GTP binding GTP-dependent protein binding GTPase activator activity GTPase activity identical protein binding lipid binding microtubule binding molecular adaptor activity protein homodimerization activity small GTPase binding ubiquitin protein ligase binding Homo sapiens 3D-structure Acetylation Alternative splicing Biological rhythms Coated pit Cytoplasm Cytoplasmic vesicle Disease variant Endocytosis Glycoprotein Golgi apparatus GTP-binding Hydrolase Isopeptide bond Lipid-binding Membrane Mitochondrion Mitochondrion outer membrane Necrosis Nucleotide-binding Peroxisome Phosphoprotein Reference proteome S-nitrosylation Synapse Ubl conjugation MEALIPVINK MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW |
negative regulation of optical nerve axon regeneration RNA processing | nucleoplasm; nucleus | ATP binding RNA binding RNA-3'-phosphate cyclase activity | Homo sapiens | Alternative splicing ATP-binding Direct protein sequencing Ligase Nucleotide-binding Nucleus Reference proteome | MAGPRVEVDG | MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL | negative regulation of optical nerve axon regeneration RNA processing nucleoplasm; nucleus ATP binding RNA binding RNA-3'-phosphate cyclase activity Homo sapiens Alternative splicing ATP-binding Direct protein sequencing Ligase Nucleotide-binding Nucleus Reference proteome MAGPRVEVDG MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIGMTNPNL |
centriole replication cilium assembly de novo centriole assembly involved in multi-ciliated epithelial cell differentiation positive regulation of centriole replication protein phosphorylation trophoblast giant cell differentiation | centriole; centrosome; cleavage furrow; cytosol; deuterosome; nucleolus; procentriole; procentriole replication complex; XY body | ATP binding identical protein binding protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Cytoskeleton Dwarfism Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MATCIGEKIE | MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH | centriole replication cilium assembly de novo centriole assembly involved in multi-ciliated epithelial cell differentiation positive regulation of centriole replication protein phosphorylation trophoblast giant cell differentiation centriole; centrosome; cleavage furrow; cytosol; deuterosome; nucleolus; procentriole; procentriole replication complex; XY body ATP binding identical protein binding protein serine kinase activity protein serine/threonine kinase activity Homo sapiens 3D-structure Acetylation Alternative splicing ATP-binding Cytoplasm Cytoskeleton Dwarfism Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation MATCIGEKIE MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH |
calcium ion-regulated exocytosis of neurotransmitter cellular response to calcium ion chemical synaptic transmission regulation of calcium ion-dependent exocytosis regulation of dopamine secretion synaptic vesicle endocytosis | axon; dense core granule; exocytic vesicle; neuronal cell body; neuronal dense core vesicle membrane; perinuclear region of cytoplasm; plasma membrane; proximal neuron projection; recycling endosome membrane; synaptic vesicle membrane | calcium ion binding calcium-dependent phospholipid binding clathrin binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding protein heterodimerization activity syntaxin binding | Homo sapiens | 3D-structure Alternative splicing Calcium Cytoplasmic vesicle Endosome Membrane Metal-binding Reference proteome Repeat Synapse Transmembrane Transmembrane helix | MFPEPPTPGP | MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP | calcium ion-regulated exocytosis of neurotransmitter cellular response to calcium ion chemical synaptic transmission regulation of calcium ion-dependent exocytosis regulation of dopamine secretion synaptic vesicle endocytosis axon; dense core granule; exocytic vesicle; neuronal cell body; neuronal dense core vesicle membrane; perinuclear region of cytoplasm; plasma membrane; proximal neuron projection; recycling endosome membrane; synaptic vesicle membrane calcium ion binding calcium-dependent phospholipid binding clathrin binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding protein heterodimerization activity syntaxin binding Homo sapiens 3D-structure Alternative splicing Calcium Cytoplasmic vesicle Endosome Membrane Metal-binding Reference proteome Repeat Synapse Transmembrane Transmembrane helix MFPEPPTPGP MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTGKKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQWHSLRPPDRVRLLPAP |
nervous system development transmembrane receptor protein tyrosine kinase signaling pathway | external side of plasma membrane; extrinsic component of membrane; plasma membrane; receptor complex | glial cell-derived neurotrophic factor receptor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Glycoprotein GPI-anchor Lipoprotein Membrane Receptor Reference proteome Signal | MILANVFCLF | MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL | nervous system development transmembrane receptor protein tyrosine kinase signaling pathway external side of plasma membrane; extrinsic component of membrane; plasma membrane; receptor complex glial cell-derived neurotrophic factor receptor activity Homo sapiens 3D-structure Alternative splicing Cell membrane Glycoprotein GPI-anchor Lipoprotein Membrane Receptor Reference proteome Signal MILANVFCLF MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL |
B cell differentiation cellular response to insulin stimulus immune response insulin receptor signaling pathway intracellular glucose homeostasis negative regulation of MAPK cascade phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol phosphate biosynthetic process positive regulation of cell adhesion positive regulation of protein import into nucleus positive regulation of transcription by RNA polymerase II protein transport regulation of actin filament polymerization regulation of autophagy regulation of protein localization to plasma membrane regulation of stress fiber assembly response to endoplasmic reticulum stress T cell differentiation | cytosol; focal adhesion; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA | 1-phosphatidylinositol-3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding phosphotyrosine residue binding protein heterodimerization activity protein phosphatase binding receptor tyrosine kinase binding | Homo sapiens | 3D-structure Disease variant Phosphoprotein Protein transport Reference proteome Repeat SH2 domain SH3 domain Stress response Transport Ubl conjugation | MAGPEGFQYR | MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR | B cell differentiation cellular response to insulin stimulus immune response insulin receptor signaling pathway intracellular glucose homeostasis negative regulation of MAPK cascade phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol phosphate biosynthetic process positive regulation of cell adhesion positive regulation of protein import into nucleus positive regulation of transcription by RNA polymerase II protein transport regulation of actin filament polymerization regulation of autophagy regulation of protein localization to plasma membrane regulation of stress fiber assembly response to endoplasmic reticulum stress T cell differentiation cytosol; focal adhesion; nucleus; phosphatidylinositol 3-kinase complex; phosphatidylinositol 3-kinase complex, class IA 1-phosphatidylinositol-3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding phosphotyrosine residue binding protein heterodimerization activity protein phosphatase binding receptor tyrosine kinase binding Homo sapiens 3D-structure Disease variant Phosphoprotein Protein transport Reference proteome Repeat SH2 domain SH3 domain Stress response Transport Ubl conjugation MAGPEGFQYR MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR |
glycoprotein catabolic process oligosaccharide catabolic process protein modification process | azurophil granule membrane; lysosomal lumen; plasma membrane | beta-mannosidase activity mannose binding | Homo sapiens | Disulfide bond Glycoprotein Glycosidase Hydrolase Lysosome Reference proteome Signal | MRLHLLLLLA | MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY | glycoprotein catabolic process oligosaccharide catabolic process protein modification process azurophil granule membrane; lysosomal lumen; plasma membrane beta-mannosidase activity mannose binding Homo sapiens Disulfide bond Glycoprotein Glycosidase Hydrolase Lysosome Reference proteome Signal MRLHLLLLLA MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY |
apoptotic process interleukin-17-mediated signaling pathway mRNA stabilization positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination regulation of apoptotic process regulation of canonical NF-kappaB signal transduction signal transduction signal transduction involved in regulation of gene expression tumor necrosis factor-mediated signaling pathway | CD40 receptor complex; centrosome; cytoplasmic side of plasma membrane; cytosol | identical protein binding thioesterase binding tumor necrosis factor receptor binding ubiquitin protein ligase binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Apoptosis Coiled coil Cytoplasm Isopeptide bond Metal-binding Reference proteome Repeat Ubl conjugation Zinc Zinc-finger | MAYSEEHKGM | MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL | apoptotic process interleukin-17-mediated signaling pathway mRNA stabilization positive regulation of canonical NF-kappaB signal transduction positive regulation of cell population proliferation positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein K63-linked ubiquitination regulation of apoptotic process regulation of canonical NF-kappaB signal transduction signal transduction signal transduction involved in regulation of gene expression tumor necrosis factor-mediated signaling pathway CD40 receptor complex; centrosome; cytoplasmic side of plasma membrane; cytosol identical protein binding thioesterase binding tumor necrosis factor receptor binding ubiquitin protein ligase binding zinc ion binding Homo sapiens 3D-structure Alternative splicing Apoptosis Coiled coil Cytoplasm Isopeptide bond Metal-binding Reference proteome Repeat Ubl conjugation Zinc Zinc-finger MAYSEEHKGM MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL |
hydroxylysine biosynthetic process peptidyl-lysine hydroxylation protein modification process response to hypoxia | endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; rough endoplasmic reticulum membrane | iron ion binding L-ascorbic acid binding procollagen-lysine 5-dioxygenase activity | Homo sapiens | Alternative splicing Dioxygenase Disease variant Endoplasmic reticulum Glycoprotein Iron Membrane Metal-binding Osteogenesis imperfecta Oxidoreductase Phosphoprotein Reference proteome Signal Vitamin C | MGGCTVKPQL | MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP | hydroxylysine biosynthetic process peptidyl-lysine hydroxylation protein modification process response to hypoxia endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; rough endoplasmic reticulum membrane iron ion binding L-ascorbic acid binding procollagen-lysine 5-dioxygenase activity Homo sapiens Alternative splicing Dioxygenase Disease variant Endoplasmic reticulum Glycoprotein Iron Membrane Metal-binding Osteogenesis imperfecta Oxidoreductase Phosphoprotein Reference proteome Signal Vitamin C MGGCTVKPQL MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP |
angiogenesis animal organ morphogenesis brain development cell growth involved in cardiac muscle cell development definitive hemopoiesis embryonic pattern specification eye development hemopoiesis lens morphogenesis in camera-type eye locomotory behavior megakaryocyte development negative regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II | chromatin; nucleus; transcription regulator complex | chromatin binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Activator Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription | MAQRYDDLPH | MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM | angiogenesis animal organ morphogenesis brain development cell growth involved in cardiac muscle cell development definitive hemopoiesis embryonic pattern specification eye development hemopoiesis lens morphogenesis in camera-type eye locomotory behavior megakaryocyte development negative regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II chromatin; nucleus; transcription regulator complex chromatin binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens 3D-structure Activator Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription MAQRYDDLPH MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM |
epithelial cell apoptotic process establishment of planar polarity exocytosis Golgi to plasma membrane transport membrane fission mitotic cytokinesis non-motile cilium assembly post-Golgi vesicle-mediated transport protein localization to plasma membrane protein transport vesicle docking involved in exocytosis vesicle tethering involved in exocytosis | cytoplasm; cytosol; exocyst; midbody | small GTPase binding | Homo sapiens | Acetylation Coiled coil Cytoplasm Exocytosis Phosphoprotein Protein transport Reference proteome Transport | MATTAELFEE | MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAVLLHFKGYSHCVDVYIKQCQEGAYLRNDIFEDAGILCQRVNKQVGDIFSNPETVLAKLIQNVFEIKLQSFVKEQLEECRKSDAEQYLKNLYDLYTRTTNLSSKLMEFNLGTDKQTFLSKLIKSIFISYLENYIEVETGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS | epithelial cell apoptotic process establishment of planar polarity exocytosis Golgi to plasma membrane transport membrane fission mitotic cytokinesis non-motile cilium assembly post-Golgi vesicle-mediated transport protein localization to plasma membrane protein transport vesicle docking involved in exocytosis vesicle tethering involved in exocytosis cytoplasm; cytosol; exocyst; midbody small GTPase binding Homo sapiens Acetylation Coiled coil Cytoplasm Exocytosis Phosphoprotein Protein transport Reference proteome Transport MATTAELFEE MATTAELFEEPFVADEYIERLVWRTPGGGSRGGPEAFDPKRLLEEFVNHIQELQIMDERIQRKVEKLEQQCQKEAKEFAKKVQELQKSNQVAFQHFQELDEHISYVATKVCHLGDQLEGVNTPRQRAVEAQKLMKYFNEFLDGELKSDVFTNSEKIKEAADIIQKLHLIAQELPFDRFSEVKSKIASKYHDLECQLIQEFTSAQRRGEISRMREVAAVLLHFKGYSHCVDVYIKQCQEGAYLRNDIFEDAGILCQRVNKQVGDIFSNPETVLAKLIQNVFEIKLQSFVKEQLEECRKSDAEQYLKNLYDLYTRTTNLSSKLMEFNLGTDKQTFLSKLIKSIFISYLENYIEVETGYLKSRSAMILQRYYDSKNHQKRSIGTGGIQDLKERIRQRTNLPLGPSIDTHGETFLSQEVVVNLLQETKQAFERCHRLSDPSDLPRNAFRIFTILVEFLCIEHIDYALETGLAGIPSSDSRNANLYFLDVVQQANTIFHLFDKQFNDHLMPLISSSPKLSECLQKKKEIIEQMEMKLDTGIDRTLNCMIGQMKHILAAEQKKTDFKPEDENNVLIQYTNACVKVCAYVRKQVEKIKNSMDGKNVDTVLMELGVRFHRLIYEHLQQYSYSCMGGMLAICDVAEYRKCAKDFKIPMVLHLFDTLHALCNLLVVAPDNLKQVCSGEQLANLDKNILHSFVQLRADYRSARLARHFS |
positive regulation of transcription elongation by RNA polymerase II snRNA transcription by RNA polymerase II transcription elongation by RNA polymerase II | nucleoplasm; transcription elongation factor complex | cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MAAGGTGGLR | MAAGGTGGLREEQRYGLSCGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQTFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPSQNAAGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWS | positive regulation of transcription elongation by RNA polymerase II snRNA transcription by RNA polymerase II transcription elongation by RNA polymerase II nucleoplasm; transcription elongation factor complex cis-regulatory region sequence-specific DNA binding Homo sapiens 3D-structure Alternative splicing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation MAAGGTGGLR MAAGGTGGLREEQRYGLSCGRLGQDNITVLHVKLTETAIRALETYQSHKNLIPFRPSIQFQGLHGLVKIPKNDPLNEVHNFNFYLSNVGKDNPQGSFDCIQQTFSSSGASQLNCLGFIQDKITVCATNDSYQMTRERMTQAEEESRNRSTKVIKPGGPYVGKRVQIRKAPQAVSDTVPERKRSTPMNPANTIRKTHSSSTISQRPYRDRVIHLLALKAYKKPELLARLQKDGVNQKDKNSLGAILQQVANLNSKDLSYTLKDYVFKELQRDWPGYSEIDRRSLESVLSRKLNPSQNAAGTSRSESPVCSSRDAVSSPQKRLLDSEFIDPLMNKKARISHLTNRVPPTLNGHLNPTSEKSAAGLPLPPAAAAIPTPPPLPSTYLPISHPPQIVNSNSNSPSTPEGRGTQDLPVDSFSQNDSIYEDQQDKYTSRTSLETLPPGSVLLKCPKPMEENHSMSHKKSKKKSKKHKEKDQIKKHDIETIEEKEEDLKREEEIAKLNNSSPNSSGGVKEDCTASMEPSAIELPDYLIKYIAIVSYEQRQNYKDDFNAEYDEYRALHARMETVARRFIKLDAQRKRLSPGSKEYQNVHEEVLQEYQKIKQSSPNYHEEKYRCEYLHNKLAHIKRLIGEFDQQQAESWS |
glucose-6-phosphate transport monoatomic anion transport monoatomic ion transmembrane transport organic anion transport phosphate ion transport sodium ion transport urate metabolic process urate transport xenobiotic detoxification by transmembrane export across the plasma membrane | apical plasma membrane; brush border membrane; cytoplasm; endoplasmic reticulum membrane; perinuclear region of cytoplasm; plasma membrane | efflux transmembrane transporter activity organic anion transmembrane transporter activity sodium:phosphate symporter activity toxin transmembrane transporter activity urate transmembrane transporter activity voltage-gated monoatomic anion channel activity xenobiotic transmembrane transporter activity | Homo sapiens | Alternative splicing Cell membrane Endoplasmic reticulum Glycoprotein Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport | MATKTELSPT | MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL | glucose-6-phosphate transport monoatomic anion transport monoatomic ion transmembrane transport organic anion transport phosphate ion transport sodium ion transport urate metabolic process urate transport xenobiotic detoxification by transmembrane export across the plasma membrane apical plasma membrane; brush border membrane; cytoplasm; endoplasmic reticulum membrane; perinuclear region of cytoplasm; plasma membrane efflux transmembrane transporter activity organic anion transmembrane transporter activity sodium:phosphate symporter activity toxin transmembrane transporter activity urate transmembrane transporter activity voltage-gated monoatomic anion channel activity xenobiotic transmembrane transporter activity Homo sapiens Alternative splicing Cell membrane Endoplasmic reticulum Glycoprotein Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport MATKTELSPT MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL |
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