Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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mRNA processing positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | CTDK-1 complex; cyclin/CDK positive transcription elongation factor complex; cytoplasm; cytosol; nuclear cyclin-dependent protein kinase holoenzyme complex; nucleus | cyclin-dependent protein serine/threonine kinase activator activity | Schizosaccharomyces pombe | Cyclin Cytoplasm mRNA processing Nucleus Reference proteome Repeat Transcription | MAENENHVLS | MAENENHVLSIRMSHPYYSEKEISRILSTRDPKENNLRMQAFAWISTLSKTLKFPVRTSGLAMLLYSRFQLFFPVNEIPLLECATACLVVASKIEDTAKKFRDILLAHYLQKHPGSEVDAHSQVCYKLIEENKKRILGLERMTLELICFDFRVRHPHNYMVKFAKSLKFSSSTASIAWNVCTDAYKTYTMLKYPAHIVAVASISIACKLQQLPQPIIPRSFFAPPALTEAVIADILDLYMHYQPHTCIGNMYTTEKLLGLCVDFQRAQKNSGRPQKPPQIDPHSSSLADEYRESNKRLQESKESCARFILDCDRKYFNTE... | mRNA processing positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II CTDK-1 complex; cyclin/CDK positive transcription elongation factor complex; cytoplasm; cytosol; nuclear cyclin-dependent protein kina... |
cell division deactivation of mitotic spindle assembly checkpoint microtubule depolymerization microtubule-based movement mitotic chromosome movement towards spindle pole mitotic metaphase chromosome recapture mitotic sister chromatid biorientation mitotic sister chromatid segregation mitotic spindle elongation mitotic... | cortical microtubule; cytoplasm; cytoplasmic microtubule plus-end; cytosol; kinesin complex; kinesin I complex; kinetochore; microtubule cytoskeleton; mitotic spindle; mitotic spindle astral microtubule; mitotic spindle midzone; mitotic spindle pole body; nucleus; plus-end kinesin complex; post-anaphase microtubule arr... | ATP binding ATP hydrolysis activity microtubule binding plus-end-directed microtubule motor activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Cell division Centromere Chromosome Chromosome partition Coiled coil Cytoplasm Cytoskeleton Kinetochore Microtubule Mitosis Motor protein Nucleotide-binding Reference proteome | MKEGSSISVA | MKEGSSISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVLIFDPPEENPLAKVQKSLLPAGKRFRDVRYAFDRLFGEEASQEDVYKGTTEPLLDSVLQGYNATVFAYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKIRDLLVQDPLSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVSSRSHAVLQIYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANINRSL... | cell division deactivation of mitotic spindle assembly checkpoint microtubule depolymerization microtubule-based movement mitotic chromosome movement towards spindle pole mitotic metaphase chromosome recapture mitotic sister chromatid biorientation mitotic sister chromatid segregation mitotic spindle elongation mitotic... |
cell division G2/M transition of mitotic cell cycle mitotic spindle pole body insertion into the nuclear envelope negative regulation of G2/M transition of mitotic cell cycle positive regulation of mitotic spindle formation (spindle phase one) | cytoplasm; inner plaque of mitotic spindle pole body; meiotic spindle pole body; microtubule cytoskeleton; mitotic spindle pole body; nucleus | protein kinase activator activity signaling adaptor activity | Schizosaccharomyces pombe | Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Mitosis Reference proteome | MSETLNTPPT | MSETLNTPPTYAWVLKAFSSKLAGTVTKPVTKMSSYIEDAESDAELPQDAKEDLRPTETLTPLKSKAAQNGILKTPGTLQIKKTVNFKDISKDAATWNRPTKNNFLFTRLDDENPLMGHEEFKSPLLQSTPKPNINNPDNENKSKHDEFDNRYNININESYKNETKSNQRLGEDVPSKKKYPHSMDAEISKFKWDSNNNNDWSSLMKDCFRDVVNNNRKMKEIIKDVMIDTSQAFPSESLDEPDYTINLDAPRSSSGKYWKQKFSMLDSAHSDLELELTSIRERLESLILEKQEEINFWKQRCRALETEKIHNHQGQQSK... | cell division G2/M transition of mitotic cell cycle mitotic spindle pole body insertion into the nuclear envelope negative regulation of G2/M transition of mitotic cell cycle positive regulation of mitotic spindle formation (spindle phase one) cytoplasm; inner plaque of mitotic spindle pole body; meiotic spindle pole b... |
cell cycle intracellular signal transduction negative regulation of transcription by RNA polymerase II phosphorylation regulation of nitrogen utilization signaling | cell division site; cell tip; cytosol | ATP binding protein serine kinase activity protein serine/threonine kinase activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Cytoplasm Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MSVTPPNVQF | MSVTPPNVQFNLNGDSDHKSDNSSSSLENKLDTELKITSPPRNPPQRLHPVDFSEHADTDDDMNHPLPRVQSPVHIKNHIDPKLAEDRYRSSAARHFEPISIPPSAITSEDEDDYHGSANSSTVLPPRTENALHAASPKPSGSTGYTSPALSQNSGSGGEGESDEGSFNTQHHRSPIFQAYPSSEDLVGDPNDPYRRTRRAPIKTNPHDIPSQFIFRKLGLHHGKHGHHGHSGSLSLKSLVPNHHDKHDKHDKHEKHHSSLDLRRFFKSHQKTDKEKKPSVSKSKSSANLQDDHFGLFKKYGKFGRMLGSGAGGSVRIMK... | cell cycle intracellular signal transduction negative regulation of transcription by RNA polymerase II phosphorylation regulation of nitrogen utilization signaling cell division site; cell tip; cytosol ATP binding protein serine kinase activity protein serine/threonine kinase activity Schizosaccharomyces pombe ATP-bin... |
cell division mitotic spindle assembly checkpoint signaling negative regulation of mitotic metaphase/anaphase transition | cytosol; kinetochore; mitotic checkpoint complex; nucleus | anaphase-promoting complex binding ubiquitin ligase inhibitor activity | Schizosaccharomyces pombe | 3D-structure Cell cycle Cell division Centromere Chromosome Kinetochore Mitosis Nucleus Reference proteome | MEPLDAGKNW | MEPLDAGKNWVHMDVIEQSKENIEPRKAGHSASALAKSSSRNHTEKEVAGLQKERMGHERKIETSESLDDPLQVWIDYIKWTLDNFPQGETKTSGLVTLLERCTREFVRNPLYKDDVRYLRIWMQYVNYIDEPVELFSFLAHHHIGQESSIFYEEYANYFESRGLFQKADEVYQKGKRMKAKPFLRFQQKYQQFTHRWLEFAPQSFSSNTNSVNPLQTTFESTNIQEISQSRTKISKPKFKFSVYSDADGSGKDGQPGTWQTLGTVDQRRKENNISATSWVGEKLPLKSPRKLDPLGKFQVHCDEEVSKE | cell division mitotic spindle assembly checkpoint signaling negative regulation of mitotic metaphase/anaphase transition cytosol; kinetochore; mitotic checkpoint complex; nucleus anaphase-promoting complex binding ubiquitin ligase inhibitor activity Schizosaccharomyces pombe 3D-structure Cell cycle Cell division Centr... |
attachment of meiotic spindle microtubules to kinetochore interphase mitotic telomere clustering meiotic spindle assembly checkpoint signaling mitotic sister chromatid biorientation mitotic sister chromatid segregation mitotic spindle assembly checkpoint signaling mitotic spindle organization phosphorylation positive r... | chromosome passenger complex; chromosome, centromeric region; chromosome, telomeric region; cytoplasm; inner kinetochore; kinetochore; meiotic spindle; meiotic spindle midzone; mitotic spindle midzone; nucleolar peripheral inclusion body; spindle microtubule; spindle midzone | ATP binding histone H3S10 kinase activity protein serine kinase activity protein serine/threonine kinase activity | Schizosaccharomyces pombe | ATP-binding Cytoplasm Cytoskeleton Kinase Nucleotide-binding Nucleus Reference proteome Serine/threonine-protein kinase Transferase | MSDSKLADSL | MSDSKLADSLNCLSVSTPSTTANPGRQQLLRLAVSNQRQVNNVSLANGKENKRTSNSKFNSSLRKIEEPIAGVPSSAGPQWREFHIGMFEIGKPLGKGKFGRVYLAKEKKTGFIVALKTLHKSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVDLKIPSFVPPDARDLISRL... | attachment of meiotic spindle microtubules to kinetochore interphase mitotic telomere clustering meiotic spindle assembly checkpoint signaling mitotic sister chromatid biorientation mitotic sister chromatid segregation mitotic spindle assembly checkpoint signaling mitotic spindle organization phosphorylation positive r... |
DNA damage response mitotic DNA replication checkpoint signaling positive regulation of DNA repair positive regulation of DNA replication initiation positive regulation of nuclear cell cycle DNA replication regulation of cell cycle phase transition | Dbf4-dependent protein kinase complex; mitotic spindle pole body; nucleus | nucleic acid binding protein kinase activator activity protein serine/threonine kinase activator activity zinc ion binding | Schizosaccharomyces pombe | Cell cycle DNA damage Metal-binding Nucleus Phosphoprotein Reference proteome Zinc Zinc-finger | MNLGRCPLAP | MNLGRCPLAPRSANIVLPKHDAVSKQKEYRIEEKTNEAQREEIITWKDNREDEGEVKTDFEVVNNENIITTTPKHQTVITPKSYRKSVKRIKHDAPQNEDIPVMKGLAPINADTESKAESMAAGKVLGSKNSSQKARLQEWKRQYKKAFPHFRFYLDGCDPSVAHRVKKQIQQLGGHVETFFSGNVTHVATVRAIQDVSVKYAKQDVITKARQLNMKIWSMEKLCNRVLKTLMENDQCTTNAPTKQGNDLSYLLYVEKVQGTNERDLSVPRQDFVHFRGPYLYVHDIANIYKPILLREWQKPLPDRDVPWPTFRATSIGR... | DNA damage response mitotic DNA replication checkpoint signaling positive regulation of DNA repair positive regulation of DNA replication initiation positive regulation of nuclear cell cycle DNA replication regulation of cell cycle phase transition Dbf4-dependent protein kinase complex; mitotic spindle pole body; nucle... |
cellular response to heat chaperone cofactor-dependent protein refolding protein refolding | cytoplasm; cytosol; nucleolar peripheral inclusion body; nucleus; plasma membrane; post-mRNA release spliceosomal complex; protein aggregate center | ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone heat shock protein binding protein folding chaperone unfolded protein binding | Schizosaccharomyces pombe | Acetylation ATP-binding Cytoplasm Nucleotide-binding Phosphoprotein Reference proteome Stress response | MSKSIGIDLG | MSKSIGIDLGTTYSCVGHFSNNRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTIFDAKRLIGRKFDDPEVQSDMKHWPFKVISKDGKPVLQVEYKGETKTFTPEEISSMVLMKMRETAEAYLGGKVTDAVVTVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGLDRSNQGESNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDSRLVNHFIQEFKRKNKKDITGNARAVRRLRTACERAKRTLSSSAQASIEIDSLFEGIDFYTSITRARFEELCADLFRKTMEPVERVLR... | cellular response to heat chaperone cofactor-dependent protein refolding protein refolding cytoplasm; cytosol; nucleolar peripheral inclusion body; nucleus; plasma membrane; post-mRNA release spliceosomal complex; protein aggregate center ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone heat ... |
cell redox homeostasis cellular detoxification of hydrogen peroxide cellular response to oxidative stress hydrogen peroxide catabolic process | cytoplasm; cytosol; mitochondrion; nucleus | thioredoxin peroxidase activity | Schizosaccharomyces pombe | Antioxidant Cytoplasm Disulfide bond Mitochondrion Oxidoreductase Peroxidase Redox-active center Reference proteome Stress response | MSHFYDLAPK | MSHFYDLAPKDKDGNPFPFSNLKGKVVLVVNTASKCGFTPQYKGLEALYQKYKDRGFIILGFPCNQFGNQEPGSDEEIAQFCQKNYGVTFPVLAKINVNGDNVDPVYQFLKSQKKQLGLERIKWNFEKFLVNRQGQVIERYSSISKPEHLENDIESVL | cell redox homeostasis cellular detoxification of hydrogen peroxide cellular response to oxidative stress hydrogen peroxide catabolic process cytoplasm; cytosol; mitochondrion; nucleus thioredoxin peroxidase activity Schizosaccharomyces pombe Antioxidant Cytoplasm Disulfide bond Mitochondrion Oxidoreductase Peroxidase... |
calcium ion transmembrane transport intracellular calcium ion homeostasis manganese ion transmembrane transport manganese ion transport release of sequestered calcium ion into cytosol by Golgi | endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; nuclear envelope; plasma membrane | ABC-type manganese transporter activity ATP binding ATP hydrolysis activity calcium ion binding P-type calcium transporter activity | Schizosaccharomyces pombe | ATP-binding Calcium Calcium transport Endoplasmic reticulum Ion transport Manganese Membrane Nucleotide-binding Phosphoprotein Reference proteome Translocase Transmembrane Transmembrane helix Transport | MSVQYDAFSV | MSVQYDAFSVEQTCADLETDMYNGLSSLQEITRRNKVHGDNDLKVEDEENMVVQFLKQFVKDPLILLLFASSAISVTLGNIDDAISIALAIVIVVTVGFVQEYRSEQSLKALNNLVPHYCNVIRSGKTEHIVASKLVPGDLVILQIGDRVPADLRIVEATELEIDESNLTGENSPRKKSSEAISSNISLTERNNIAFMGTLVRHGHGRGIVVATGSDTEFGRVFLTMQQTEKPKTPLQNSMDDLGKQLSLISLIGIAVIVLVGFFQGKNWLEMLTIGVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIIRRLPSVETL... | calcium ion transmembrane transport intracellular calcium ion homeostasis manganese ion transmembrane transport manganese ion transport release of sequestered calcium ion into cytosol by Golgi endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; nuclear envelope; plasma membrane ABC-type manganese tra... |
cellulose catabolic process xylan catabolic process | extracellular region | acetylxylan esterase activity | Talaromyces purpureogenus | 3D-structure Carbohydrate metabolism Cellulose degradation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Polysaccharide degradation Secreted Serine esterase Signal | MHSKFFAASL | MHSKFFAASLLGLGAAAIPLEGVMEKRSCPAIHVFGARETTASPGYGSSSTVVNGVLSAYPGSTAEAINYPACGGQSSCGGASYSSSVAQGIAAVASAVNSFNSQCPSTKIVLVGYSQGGEIMDVALCGGGDPNQGYTNTAVQLSSSAVNMVKAAIFMGDPMFRAGLSYEVGTCAAGGFDQRPAGFSCPSAAKIKSYCDASDPYCCNGSNAATHQGYGSEYGSQALAFVKSKLG | cellulose catabolic process xylan catabolic process extracellular region acetylxylan esterase activity Talaromyces purpureogenus 3D-structure Carbohydrate metabolism Cellulose degradation Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Polysaccharide degradation Secre... |
negative regulation of DNA recombination at telomere rDNA heterochromatin formation regulation of cell differentiation | nucleus | metal ion binding NAD+ binding NAD-dependent histone H4K16 deacetylase activity transferase activity | Candida albicans | Metal-binding NAD Nucleus Reference proteome Repressor Transcription Transcription regulation Transferase Zinc | MTTFWSQTIN | MTTFWSQTINRQNGGVATATATATATAATTTPTAGGTGAGTTTSTKGMITPTPFNIDINNDLNDFDGKFIETFKPDLELQKKYRSFIQREGALSFLRTEITQSMSKRDICVLILNLGYPKKAVEDYPILTLKELAYILLKLMLTDSAQLEPKVEIDENDNKNDGTNNSDIDSDIDSNSDMDSQSESGELDDAMDVDDSLSENEDEYDQDMSTTTLKRTINMTPFKYKLPDLISDLSRAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREPGLFYTIAHLVLPPDGKFSLLHAFLKLLQDKH... | negative regulation of DNA recombination at telomere rDNA heterochromatin formation regulation of cell differentiation nucleus metal ion binding NAD+ binding NAD-dependent histone H4K16 deacetylase activity transferase activity Candida albicans Metal-binding NAD Nucleus Reference proteome Repressor Transcription Trans... |
cell redox homeostasis cellular response to oxidative stress filamentous growth filamentous growth of a population of unicellular organisms in response to starvation fungal-type cell wall organization intracellular copper ion homeostasis intracellular zinc ion homeostasis negative regulation of cellular respiration pos... | cytosol; mitochondrial intermembrane space; nucleus; superoxide dismutase complex | copper ion binding superoxide dismutase activity | Candida albicans | Antioxidant Copper Cytoplasm Disulfide bond Metal-binding Oxidoreductase Zinc | MVKAVAVVRG | MVKAVAVVRGDSKVQGTVHFEQESESAPTTISWEIEGNDPNALRGFHIHQFGDNTNGCTSAGPHFNPFGKQHGAPEDDERHVGDLGNISTDGNGVAKGTKQDLLIKLIGKDSILGRTIVVHAGTDDYGKGGFEDSKTTGHAGARPACGVIGLTQ | cell redox homeostasis cellular response to oxidative stress filamentous growth filamentous growth of a population of unicellular organisms in response to starvation fungal-type cell wall organization intracellular copper ion homeostasis intracellular zinc ion homeostasis negative regulation of cellular respiration pos... |
actin cortical patch localization actin cortical patch organization actin filament bundle assembly actin filament network formation actomyosin contractile ring organization endocytosis formin-nucleated actin cable organization | actin body; actin cortical patch; actin filament; actin filament bundle; cell division site; cytoplasm; medial cortex; mitotic actomyosin contractile ring, distal actin filament layer | actin filament binding calcium ion binding | Schizosaccharomyces pombe | 3D-structure Actin-binding Calcium Cytoplasm Cytoskeleton Metal-binding Reference proteome Repeat | MLALKLQKKY | MLALKLQKKYPELTNEEILTLTDQFNKLDVDGKGYLDQPTTIKAFEDSKKGSYDEVREAIREVNVDSSGRVEPEDFVGIFNVLKKGVEGTEVKKGRITIKGSSSSVSHTINEEERREFIKHINSVLAGDPDVGSRVPINTETFEFFDQCKDGLILSKLINDSVPDTIDERVLNKQRNNKPLDNFKCIENNNVVINSAKAMGGISITNIGAGDILEGREHLILGLVWQIIRRGLLGKIDITLHPELYRLLEEDETLDQFLRLPPEKILLRWFNYHLKAANWPRTVSNFSKDVSDGENYTVLLNQLAPELCSRAPLQTTDVL... | actin cortical patch localization actin cortical patch organization actin filament bundle assembly actin filament network formation actomyosin contractile ring organization endocytosis formin-nucleated actin cable organization actin body; actin cortical patch; actin filament; actin filament bundle; cell division site; ... |
Mo-molybdopterin cofactor biosynthetic process protein urmylation tRNA wobble position uridine thiolation | cytoplasm; cytosol | ATP binding metal ion binding molybdopterin-synthase adenylyltransferase activity molybdopterin-synthase sulfurtransferase activity nucleotidyltransferase activity thiosulfate sulfurtransferase activity URM1 activating enzyme activity | Emericella nidulans | ATP-binding Cytoplasm Metal-binding Molybdenum cofactor biosynthesis Multifunctional enzyme Nucleotide-binding Reference proteome Transferase tRNA processing Zinc | MEDLETRCAS | MEDLETRCASLRTEIAAAEAQLTKLKRELHEAEGAALRAQSQKTASANATTGQRTKSKWPLHGEEYRRYGRQMIVPQFGLQGQLKLRDAKVLIVGAGGLGCPAALYLAGAGVGTIGLVDGDTVEASNLHRQVLHRSRNVGKLKVDSAIEYLRELNPHPTYIAHQAHLTPREAPDIFKDYDLILDCTDNPATRYLISDTAVLLGKPLVSASALRTEGQLMVLNNPPQPPGDKTGGPCYRCVFPKPPPANSVTSCADGGILGPVVGTMGVLQASEAIKVLTSAGESVEATPPSLLIFSAYSSPQFRTIKLRSRRPNCAVCSA... | Mo-molybdopterin cofactor biosynthetic process protein urmylation tRNA wobble position uridine thiolation cytoplasm; cytosol ATP binding metal ion binding molybdopterin-synthase adenylyltransferase activity molybdopterin-synthase sulfurtransferase activity nucleotidyltransferase activity thiosulfate sulfurtransferase a... |
methylation pericentric heterochromatin formation positive regulation of pericentric heterochromatin formation silent mating-type cassette heterochromatin formation siRNA-dependent pericentric heterochromatin formation | chromosome, subtelomeric region; CLRC complex; cytoplasm; mating-type region heterochromatin; nucleus; pericentric heterochromatin; spindle pole body | double-stranded DNA binding histone H3K9 methyltransferase activity histone H3K9 monomethyltransferase activity histone H3K9 trimethyltransferase activity histone H3K9me2 methyltransferase activity histone methyltransferase activity histone reader activity methyltransferase activity single-stranded DNA binding single-s... | Schizosaccharomyces pombe | 3D-structure Chromatin regulator Chromosome Cytoplasm Cytoskeleton Direct protein sequencing Metal-binding Methylation Methyltransferase Nucleus Reference proteome S-adenosyl-L-methionine Transferase Zinc | MSPKQEEYEV | MSPKQEEYEVERIVDEKLDRNGAVKLYRIRWLNYSSRSDTWEPPENLSGCSAVLAEWKRRKRRLKGSNSDSDSPHHASNPHPNSRQKHQHQTSKSVPRSQRFSRELNVKKENKKVFSSQTTKRQSRKQSTALTTNDTSIILDDSLHTNSKKLGKTRNEVKEESQKRELVSNSIKEATSPKTSSILTKPRNPSKLDSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQGRVRADTGAVIYECNSFCSCSMECPNR... | methylation pericentric heterochromatin formation positive regulation of pericentric heterochromatin formation silent mating-type cassette heterochromatin formation siRNA-dependent pericentric heterochromatin formation chromosome, subtelomeric region; CLRC complex; cytoplasm; mating-type region heterochromatin; nucleus... |
protein farnesylation protein geranylgeranylation protein localization to plasma membrane | CAAX-protein geranylgeranyltransferase complex; cytoplasm; nucleus; protein farnesyltransferase complex | CAAX-protein geranylgeranyltransferase activity protein farnesyltransferase activity Rab geranylgeranyltransferase activity | Schizosaccharomyces pombe | Magnesium Prenyltransferase Reference proteome Repeat Transferase | MDPIDPELNE | MDPIDPELNEILDFTEYGPLTPIPQDDGENPLAKICYTTGYEQGMAYFRAIMAKKEYSLRALNLTGFLIMNNPAHYTVWAYRFQILNHTPSYIDNELEWLDEIAEDFQKNYQVWHHRQKILSLTKNYERELEFTKKMFEIDSKNYHVWSYRVWILQNFNDYSQELKLTNELLEKDIYNNSAWNHRFYVLFETSKVVSWSLEEELNYLKDKILFAPDNQSAWNYLCGVLDKSGPSKLDNLIANLRKNLPALHKPLLEFLAMYEPSSSEEIYQKLANEVDVPHAALWTWMSQRSNP | protein farnesylation protein geranylgeranylation protein localization to plasma membrane CAAX-protein geranylgeranyltransferase complex; cytoplasm; nucleus; protein farnesyltransferase complex CAAX-protein geranylgeranyltransferase activity protein farnesyltransferase activity Rab geranylgeranyltransferase activity Sc... |
de novo' pyrimidine nucleobase biosynthetic process arginine biosynthetic process glutamine metabolic process urea cycle | carbamoyl-phosphate synthase complex; cytoplasm; mitochondrion | ATP binding carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity glutaminase activity | Schizosaccharomyces pombe | Amino-acid biosynthesis Arginine biosynthesis ATP-binding Cytoplasm Glutamine amidotransferase Ligase Mitochondrion Nucleotide-binding Reference proteome Transit peptide | MLRFLKPFPL | MLRFLKPFPLRFGKRFYSKVPPVTNHERILPKQPSFPTAPAQNEIATLTIRNGPIFHGTSFGANRNVSGEAVFTTSPVGYVESLTDPSYKQQILIFTQPLIGNYGVPDCKKRDENGLLRHFESPHIQCAGVVVNDYATKYSHWTAVESLGEWCAREGVAAITGVDTRAIVTFLREQGSSLAKISIGEEYDANDDEAFINPEEVNLVSQVSTREPFFVSGGDGMLNIAVIDCGVKENILRSLVSRGASVTVFPFDYPIQNVASNYDGIFLTNGPGDPTHLTKTVNNLRELMNTYNGPIMGICMGHQLLALSTGAKTIKLKY... | de novo' pyrimidine nucleobase biosynthetic process arginine biosynthetic process glutamine metabolic process urea cycle carbamoyl-phosphate synthase complex; cytoplasm; mitochondrion ATP binding carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity glutaminase activity Schizosaccharomyces pombe Amino-acid bio... |
negative regulation of gene expression, epigenetic transcription initiation-coupled chromatin remodeling | chromatin; Lid2 complex; nucleus; Set1C/COMPASS complex | metal ion binding transcription cis-regulatory region binding | Schizosaccharomyces pombe | Metal-binding Nucleus Reference proteome Zinc Zinc-finger | MLAHGSNDYG | MLAHGSNDYGVSLKGNKTGSSPSKASSLNWNEPHTLNEQNTYCYCGKDRNLRFPDLQCSVCLNMFHLSCLSPPCTSMMGFSTNYQFVCKHCTEDGFERFERGVSAWKAITATAMANLVVKRYVETNPDVPVDSFNAEKMRNFQANTYFFKKKEDLIPFIEEHWQLLCPDREKVQTWQATLGSCLVANRDTYRAKDETMRNQNSEYALNNPNLFDFRSGYIFPFQRVGATVPKKRLVETETPPPSSSKLKEDYKDSKREMKRSNTPWSNASIKKNEVPTVPIRYKPPPWRDSDFETVPKLPIFYPNSSSPNFFSLSEIPFN... | negative regulation of gene expression, epigenetic transcription initiation-coupled chromatin remodeling chromatin; Lid2 complex; nucleus; Set1C/COMPASS complex metal ion binding transcription cis-regulatory region binding Schizosaccharomyces pombe Metal-binding Nucleus Reference proteome Zinc Zinc-finger MLAHGSNDYG M... |
regulation of DNA-templated transcription rRNA processing rRNA transcription | cytosol; nucleolus; nucleus | nucleotide binding rDNA binding RNA polymerase I transcription regulatory region sequence-specific DNA binding | Schizosaccharomyces pombe | Nucleus Phosphoprotein Reference proteome | MATKTQLELF | MATKTQLELFTKLTSNDKAIRLSSAAQLIDSLSNEEELKYSLNRLTKGLSSGRESARIGFAVALTELLTRTKDIRATHVLDLLVKHNTASGNLKGQDERDFYFGLLFGLQSIVYSGILTHKESTIEDFQRVVDLLLQLSGKKNWLQDVCFYVIYKLVEQIPEISFSSNAFLAVNKLLQTPAVSKSTEGVGLFLCLTRVPDNVKSEEVAMANWEPAHPLHKSNLVTLSKIMRQADASETGGQNSAWKQKIPMVWKYIFEEYQRKTYSGLAPFHDFWAVVVDEGIFSSTSSLERKFWGFQIMELALDYVSSDNIGDIFSKNF... | regulation of DNA-templated transcription rRNA processing rRNA transcription cytosol; nucleolus; nucleus nucleotide binding rDNA binding RNA polymerase I transcription regulatory region sequence-specific DNA binding Schizosaccharomyces pombe Nucleus Phosphoprotein Reference proteome MATKTQLELF MATKTQLELFTKLTSNDKAIRLSS... |
endoplasmic reticulum membrane organization endoplasmic reticulum-plasma membrane tethering establishment or maintenance of cell polarity regulating cell shape maintenance of ER location reticulophagy | cortical endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; plasma membrane | FFAT motif binding protein-membrane adaptor activity | Schizosaccharomyces pombe | Endoplasmic reticulum Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MSVECSGELF | MSVECSGELFFYPPFTTMSKELISVHNPNPEPVIFKVKTTAPKHYCVRPNSGKIEPKSTVNVQVLLQAMKEEPAPDFKCRDKFLIQSMAIGDADTSNVENYHEFWTEMEKQGRSIFDRKIRCVYSTKQPPQSADKQVENTSTSNPPVSVEGSENLASSVGGPTAVGVSLDEAQNDFNGAKDHLSNGVNTVVPDSTFRSTFESAQIPDASVVQTVVTDADNGAASVKDTIVTAESASSKGADVARSKVQDIIDNEIPKPSESPRRSVSSTPPVHPPPPVPQNLSAVNEEFDTKKNDFDSKLPESTPAVEKVSENLGSETRE... | endoplasmic reticulum membrane organization endoplasmic reticulum-plasma membrane tethering establishment or maintenance of cell polarity regulating cell shape maintenance of ER location reticulophagy cortical endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-plasma mem... |
DNA topological change maintenance of rDNA mitotic DNA replication postreplication repair resolution of meiotic recombination intermediates | nucleus; RecQ family helicase-topoisomerase III complex; site of double-strand break | DNA binding DNA topoisomerase activity DNA topoisomerase type I (single strand cut, ATP-independent) activity | Schizosaccharomyces pombe | DNA-binding Isomerase Reference proteome Topoisomerase | MRVLCVAEKN | MRVLCVAEKNSIAKSVASILGGGHVRRRDTRSKYVKNYDFSFNFGGNVGSSDVTMTSVSGHLTEASFPSEYSSWSSVPQDVLFDAQIITSVSKNAEVLADNIKKEARNAQYLYIWTDCDREGEHIGVEISNVARASNPSIQVIRADFNNLERSHIISAAKRPRDVSKNAADAVDARIELDFRLGAIFTRLQTIQLQKSFDILQNKIISYGPCQFPTLGFVVDRWQRVEDFVPETYWHLRFVDKRQGKTIQFNWERAKVFDRLTTMIILENCLECKTAKVVNITQKPKTKYKPLPLSTVELTKLGPKHLRISAKKTLELAE... | DNA topological change maintenance of rDNA mitotic DNA replication postreplication repair resolution of meiotic recombination intermediates nucleus; RecQ family helicase-topoisomerase III complex; site of double-strand break DNA binding DNA topoisomerase activity DNA topoisomerase type I (single strand cut, ATP-indepen... |
chromatin organization division septum assembly negative regulation of cell cycle switching, mitotic to meiotic cell cycle positive regulation of induction of conjugation with cellular fusion positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; M/G1 phase-specific MADS box-forkhead transcription factor complex; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Schizosaccharomyces pombe | Activator Cell cycle Cell division DNA-binding Mitosis Nucleus Phosphoprotein Reference proteome Septation Transcription Transcription regulation | MTVRRLESKS | MTVRRLESKSEHISDDEERKEQLDYKKQMDVDTDRNIVLNGRLESQIAKLSVPPHEMRVVDDYSNSKNAERHSGEIQAYAKFAGSTWTYYVKKIRIILGREPANPSPKGKNEDLEVIDMNFGPSKVVSRKHAVVEYDLDDQTWNCSVYGRNGIKVDGKLFKNGETVKLTSGSILEVAGLQMMFVLPNAAEQKQTDESTIKEDAIKSEISAAVNDAAEYGDNKKPPYSYSVMIAQAILSSSECMMTLSNIYSWISTHYPYYRTTKSGWQNSIRHNLSLNKAFRKVPRKSGEQGKGMKWSIVPEFREEFIAKTRKTPRKRSP... | chromatin organization division septum assembly negative regulation of cell cycle switching, mitotic to meiotic cell cycle positive regulation of induction of conjugation with cellular fusion positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; M/G1 phase... |
establishment of bipolar cell polarity establishment or maintenance of actin cytoskeleton polarity establishment or maintenance of bipolar cell polarity maintenance of protein location in cell cortex of cell tip negative regulation of protein localization to cell tip positive regulation of establishment of cell polarit... | cell cortex of cell tip; cell division site; cell tip; lateral cell cortex; microtubule cytoskeleton; microtubule plus-end; non-growing cell tip; old growing cell tip | cytoskeletal anchor activity | Schizosaccharomyces pombe | Cytoplasm Cytoskeleton Phosphoprotein Reference proteome SH3 domain | MLHMNSASSA | MLHMNSASSADSMEIMESHFDPTQQNDSTIIESRYSPEEYLEQSFEIQRIISGENSEPQTVASQEISDSQEEDTTLTSSQFEDCGTEYNEVVEDDEFRSEDEDDFMDEEEEYALYEAELSSSPSIHEEVIDCNFVHAIRGFEATVEGQVDATKGDMMILLDDSNSYWWLVKMCKNLAIGYLPAEYIETPSERLARLNKYKNSETSNSQQSVTLPPLDIVEKTLEAPSPNFRIKRVTFTCSSNSSDDEMDSENDYEAMVNRTVAENGLEIEFSDSSDSSLSAEYRSESEDHVTDSPAYVDLTELEGGFNQFNSTSFQSTSP... | establishment of bipolar cell polarity establishment or maintenance of actin cytoskeleton polarity establishment or maintenance of bipolar cell polarity maintenance of protein location in cell cortex of cell tip negative regulation of protein localization to cell tip positive regulation of establishment of cell polarit... |
cell division meiotic attachment of telomere to nuclear envelope meiotic telomere clustering meiotic telomere tethering at nuclear periphery mitotic telomere tethering at nuclear periphery telomere maintenance telomere organization | cytoplasm; nuclear envelope; nuclear inner membrane; nuclear membrane complex Bqt3-Bqt4; nucleus | DNA binding telomere-nuclear envelope anchor activity | Schizosaccharomyces pombe | 3D-structure Cell cycle Cell division Chromosome partition Cytoplasm DNA-binding Meiosis Membrane Nucleus Reference proteome | MTENEKSRSL | MTENEKSRSLPAERNPLYKDDTLDHTPLIPKCRAQVIEFPDGPATFVRLKCTNPESKVPHFLMRMAKDSSISATSMFRSAFPKATQEEEDLEMRWIRDNLNPIEDKRVAGLWVPPADALALAKDYSMTPFINALLEASSTPSTYATPSRPTAQKSETSEGEPESSTSATTTSVARRTRQRLAEHLENSKKTILQHDNKEEDKEIHSEENETKDEIKSEKKEPEIKKQEGGSSTEKVGQPSSSDDKAKGSTSKDQPSEEEEKTSDIQDRKIKTPIKPSLLGKIRSSVNKGMTDVASQVNRGMTDVASQVNKGVNGVASQVN... | cell division meiotic attachment of telomere to nuclear envelope meiotic telomere clustering meiotic telomere tethering at nuclear periphery mitotic telomere tethering at nuclear periphery telomere maintenance telomere organization cytoplasm; nuclear envelope; nuclear inner membrane; nuclear membrane complex Bqt3-Bqt4;... |
cytoskeleton-dependent cytokinesis spore membrane bending pathway | cell division site; cytosol; mating projection septin ring; meiotic septin complex; membrane; microtubule cytoskeleton; nucleus; prospore septin ring; septin complex; septin ring | GTP binding GTPase activity lipid binding molecular adaptor activity | Schizosaccharomyces pombe | Cytoplasm GTP-binding Lipid-binding Meiosis Membrane Nucleotide-binding Nucleus Reference proteome Sporulation | MNKGPRHRPK | MNKGPRHRPKFLSKKGKKLRIMVAGSSYTSYQACINSLCSKQILEAETEIDPLKAHIDRILEIREFNADILEDEFHVDLTVIEVNGFGDKIDNSASFEVVTHYLESQFDQALIEESKIKRNSKFTDTRVDALLYFIAPRGHCLSEFDLEAMKRFSKRVNVIPVIGNSNAFTEEELKNFKDVIMKDLKQCNIKVFDFPWDPEEDEDEVIEDNKRLWESVPFAVSGGVSEEDEEGYQRIVKKFQWGTFVIDDPAHSDFLNLKTVLFISHLDILKSITKQTYYENYRTEKLSNDSPSNTSLSLQKQNSIVANEDKRSVNGSER... | cytoskeleton-dependent cytokinesis spore membrane bending pathway cell division site; cytosol; mating projection septin ring; meiotic septin complex; membrane; microtubule cytoskeleton; nucleus; prospore septin ring; septin complex; septin ring GTP binding GTPase activity lipid binding molecular adaptor activity Schizo... |
cell division DNA strand elongation involved in DNA replication mitotic DNA replication leading strand elongation UV-damage excision repair | chromatin; nuclear DNA replication factor C complex; nucleolus; nucleus | ATP binding ATP hydrolysis activity chromatin binding DNA binding DNA clamp loader activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Cell division DNA replication DNA-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MSNSDIRSFF | MSNSDIRSFFGGGNAQKKPKVSPTPTSPKPKRSLKKKRIVLSDDEDGTIENSKVPASKSKVQKRNESEDISHSLPSIVHEDDKLVGSDGVSTTPDEYFEQQSTRSRSKPRIISNKETTTSKDVVHPVKTENFANDLDTTSDSKPVVHQTRATRKPAQPKAEKSTTSKSKSHTTTATTHTSRSSKSKGLPRFSDEVSQALKNVPLIDVDSMGVMAPGTFYERAATTQTPGSKPVPEGNSDCLSGISFVITGILETLTRQEATDLIKQYGGKVTGAPSVRTDFILLGENAGPRKVETIKQHKIPAINEDGLFYLITHLPASG... | cell division DNA strand elongation involved in DNA replication mitotic DNA replication leading strand elongation UV-damage excision repair chromatin; nuclear DNA replication factor C complex; nucleolus; nucleus ATP binding ATP hydrolysis activity chromatin binding DNA binding DNA clamp loader activity Schizosaccharomy... |
apoptotic process cell division chromatin looping chromosome segregation DNA recombination double-strand break repair establishment of meiotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion negative regulation of G2/M transition of mitotic cell cycle negative regulation of glial cell apopt... | chromatin; chromosome; chromosome, centromeric region; cohesin complex; condensed nuclear chromosome; cytosol; meiotic cohesin complex; membrane; midbody; mitotic cohesin complex; nuclear matrix; nucleoplasm; nucleus; spindle pole | chromatin binding DNA binding DNA-binding transcription factor binding lncRNA binding | Homo sapiens | 3D-structure Activator Apoptosis Cell cycle Cell division Centromere Chromosome Chromosome partition Cytoplasm Cytoskeleton Developmental protein Direct protein sequencing Disease variant DNA damage DNA repair DNA-binding Intellectual disability Isopeptide bond Mitosis Nucleus Phosphoprotein Reference proteome Represso... | MFYAHFVLSK | MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKR... | apoptotic process cell division chromatin looping chromosome segregation DNA recombination double-strand break repair establishment of meiotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion negative regulation of G2/M transition of mitotic cell cycle negative regulation of glial cell apopt... |
cellular detoxification of aldehyde daunorubicin metabolic process doxorubicin metabolic process farnesol catabolic process retinoid metabolic process | cytosol; extracellular region; lysosome; mitochondrion | alcohol dehydrogenase (NADP+) activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity allyl-alcohol dehydrogenase activity geranylgeranyl reductase activity indanol dehydrogenase activity NADP-retinol dehydrogenase activity retinal dehydrogenase activity | Homo sapiens | 3D-structure Acetylation Lipid metabolism Lysosome NADP Oxidoreductase Reference proteome Secreted | MATFVELSTK | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY | cellular detoxification of aldehyde daunorubicin metabolic process doxorubicin metabolic process farnesol catabolic process retinoid metabolic process cytosol; extracellular region; lysosome; mitochondrion alcohol dehydrogenase (NADP+) activity alditol:NADP+ 1-oxidoreductase activity aldo-keto reductase (NADP) activity... |
nervous system development protein insertion into mitochondrial inner membrane | mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; mitochondrion | identical protein binding metal ion binding | Homo sapiens | Chaperone Deafness Disease variant Disulfide bond Dystonia Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Phosphoprotein Protein transport Reference proteome Translocation Transport Zinc | MDSSSSSSAA | MDSSSSSSAAGLGAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD | nervous system development protein insertion into mitochondrial inner membrane mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; mitochondrion identical protein binding metal ion binding Homo sapiens Chaperone Deafness Disease variant Disulfi... |
proteolysis respiratory gaseous exchange by respiratory system | extracellular exosome; extracellular region; plasma membrane | peptidase activity serine-type endopeptidase activity | Homo sapiens | Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Membrane Protease Reference proteome Secreted Serine protease Signal-anchor Transmembrane Transmembrane helix Zymogen | MYRPARVTST | MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHT... | proteolysis respiratory gaseous exchange by respiratory system extracellular exosome; extracellular region; plasma membrane peptidase activity serine-type endopeptidase activity Homo sapiens Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Membrane Protease Reference proteome Secreted Serin... |
regulation of muscle contraction signal transduction | A band; cytoplasm; cytosol; nucleoplasm; stress fiber; Z disc | enzyme activator activity enzyme inhibitor activity phosphatase regulator activity protein kinase binding | Homo sapiens | Alternative promoter usage Alternative splicing ANK repeat Cytoplasm Cytoskeleton Phosphoprotein Reference proteome Repeat | MAELEHLGGK | MAELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGVDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLIE... | regulation of muscle contraction signal transduction A band; cytoplasm; cytosol; nucleoplasm; stress fiber; Z disc enzyme activator activity enzyme inhibitor activity phosphatase regulator activity protein kinase binding Homo sapiens Alternative promoter usage Alternative splicing ANK repeat Cytoplasm Cytoskeleton Phos... |
cellular response to hypoxia defense response to virus mitochondrial outer membrane permeabilization mitochondrial protein catabolic process negative regulation of apoptotic process negative regulation of mitochondrial membrane potential negative regulation of programmed cell death positive regulation of apoptotic proc... | endoplasmic reticulum; membrane; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear speck; nucleus | identical protein binding lamin binding protein homodimerization activity | Homo sapiens | Alternative splicing Apoptosis Endoplasmic reticulum Host-virus interaction Membrane Mitochondrion Mitochondrion outer membrane Nucleus Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MSSHLVEPPP | MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSASTY | cellular response to hypoxia defense response to virus mitochondrial outer membrane permeabilization mitochondrial protein catabolic process negative regulation of apoptotic process negative regulation of mitochondrial membrane potential negative regulation of programmed cell death positive regulation of apoptotic proc... |
intracellular signal transduction signal transduction | cytoplasm; cytoplasmic vesicle membrane; mitochondrion; nuclear body; nucleoplasm | guanyl-nucleotide exchange factor activity protein kinase inhibitor activity SH3 domain binding | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasmic vesicle Guanine-nucleotide releasing factor Membrane Mitochondrion Phosphoprotein Reference proteome SH3-binding | MDAALKRSRS | MDAALKRSRSEEPAEILPPARDEEEEEEEGMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELVKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLTLAKGEYKMALKNLEMISDEIHERRRSSAMGPRGCGVGAEGSSTSVEDLPGSKPEPDAISVASEAFEDDSCSNFVSEDDSETQS... | intracellular signal transduction signal transduction cytoplasm; cytoplasmic vesicle membrane; mitochondrion; nuclear body; nucleoplasm guanyl-nucleotide exchange factor activity protein kinase inhibitor activity SH3 domain binding Homo sapiens 3D-structure Alternative splicing Coiled coil Cytoplasmic vesicle Guanine-n... |
cellular response to cold lipid catabolic process lipid metabolic process | cytosol; endoplasmic reticulum; lipid droplet | lipid binding | Homo sapiens | Endoplasmic reticulum Lipid droplet Lipid metabolism Phosphoprotein Reference proteome | MAVNKGLTLL | MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFS... | cellular response to cold lipid catabolic process lipid metabolic process cytosol; endoplasmic reticulum; lipid droplet lipid binding Homo sapiens Endoplasmic reticulum Lipid droplet Lipid metabolism Phosphoprotein Reference proteome MAVNKGLTLL MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEP... |
angiogenesis heparan sulfate proteoglycan biosynthetic process, enzymatic modification labyrinthine layer blood vessel development lung alveolus development neuron development | Golgi membrane; plasma membrane | heparan sulfate 6-O-sulfotransferase activity sulfotransferase activity | Homo sapiens | Alternative splicing Coiled coil Disease variant Glycoprotein Hypogonadotropic hypogonadism Kallmann syndrome Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MRRRRAGGRT | MRRRRAGGRTMVERASKFVLVVAGSVCFMLILYQYAGPGLSLGAPGGRAPPDDLDLFPTPDPHYEKKYYFPVRELERSLRFDMKGDDVIVFLHIQKTGGTTFGRHLVQNVRLEVPCDCRPGQKKCTCYRPNRRETWLFSRFSTGWSCGLHADWTELTNCVPGVLDRRDSAALRTPRKFYYITLLRDPVSRYLSEWRHVQRGATWKTSLHMCDGRTPTPEELPPCYEGTDWSGCTLQEFMDCPYNLANNRQVRMLADLSLVGCYNLSFIPEGKRAQLLLESAKKNLRGMAFFGLTEFQRKTQYLFERTFNLKFIRPFMQYN... | angiogenesis heparan sulfate proteoglycan biosynthetic process, enzymatic modification labyrinthine layer blood vessel development lung alveolus development neuron development Golgi membrane; plasma membrane heparan sulfate 6-O-sulfotransferase activity sulfotransferase activity Homo sapiens Alternative splicing Coiled... |
anatomical structure morphogenesis cell differentiation chromatin organization male gonad development myoblast development negative regulation of striated muscle tissue development negative regulation of transcription by RNA polymerase II positive regulation of G0 to G1 transition positive regulation of myoblast prolif... | chromatin; cytoplasm; nucleus; transcription regulator complex | chromatin binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Activator Alternative splicing DNA-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation | MALPGSSQDQ | MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL | anatomical structure morphogenesis cell differentiation chromatin organization male gonad development myoblast development negative regulation of striated muscle tissue development negative regulation of transcription by RNA polymerase II positive regulation of G0 to G1 transition positive regulation of myoblast prolif... |
5-phosphoribose 1-diphosphate biosynthetic process bone development nucleobase-containing compound metabolic process purine nucleotide biosynthetic process | cytoplasm; ribose phosphate diphosphokinase complex | ATP binding enzyme inhibitor activity identical protein binding magnesium ion binding ribose phosphate diphosphokinase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Direct protein sequencing Nucleotide biosynthesis Phosphoprotein Reference proteome | MFCVTPPELE | MFCVTPPELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV... | 5-phosphoribose 1-diphosphate biosynthetic process bone development nucleobase-containing compound metabolic process purine nucleotide biosynthetic process cytoplasm; ribose phosphate diphosphokinase complex ATP binding enzyme inhibitor activity identical protein binding magnesium ion binding ribose phosphate diphospho... |
animal organ morphogenesis cell differentiation cell-cell signaling fibroblast growth factor receptor signaling pathway nervous system development positive regulation of cell population proliferation positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell migration signa... | cytoplasm; extracellular region; extracellular space | growth factor activity type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding | Homo sapiens | Alternative splicing Developmental protein Disease variant Glycoprotein Growth factor Hypogonadotropic hypogonadism Kallmann syndrome Reference proteome Secreted Signal | MGAARLLPNL | MGAARLLPNLTLCLQLLILCCQTQGENHPSPNFNQYVRDQGAMTDQLSRRQIREYQLYSRTSGKHVQVTGRRISATAEDGNKFAKLIVETDTFGSRVRIKGAESEKYICMNKRGKLIGKPSGKSKDCVFTEIVLENNYTAFQNARHEGWFMAFTRQGRPRQASRSRQNQREAHFIKRLYQGQLPFPNHAEKQKQFEFVGSAPTRRTKRTRRPQPLT | animal organ morphogenesis cell differentiation cell-cell signaling fibroblast growth factor receptor signaling pathway nervous system development positive regulation of cell population proliferation positive regulation of gene expression positive regulation of protein phosphorylation regulation of cell migration signa... |
keratinocyte proliferation memory neuron projection morphogenesis proteolysis regulation of synapse organization response to wounding synapse organization | cytoplasm; extracellular region; extracellular space; secretory granule; serine protease inhibitor complex | serine-type endopeptidase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Secreted Serine protease Signal Zymogen | MGRPRPRAAK | MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG | keratinocyte proliferation memory neuron projection morphogenesis proteolysis regulation of synapse organization response to wounding synapse organization cytoplasm; extracellular region; extracellular space; secretory granule; serine protease inhibitor complex serine-type endopeptidase activity Homo sapiens 3D-structu... |
anterograde axonal protein transport anterograde dendritic transport of messenger ribonucleoprotein complex anterograde dendritic transport of neurotransmitter receptor complex axon guidance intracellular mRNA localization motor neuron axon guidance mRNA transport organelle organization synaptic vesicle transport | axon cytoplasm; axonal growth cone; ciliary rootlet; dendrite cytoplasm; distal axon; kinesin complex; microtubule; neuronal cell body; postsynaptic cytosol | apolipoprotein receptor binding ATP binding ATP hydrolysis activity microtubule binding microtubule motor activity plus-end-directed microtubule motor activity | Homo sapiens | Alternative splicing ATP-binding Cell projection Coiled coil Cytoplasm Cytoskeleton Disease variant Hydrolase Microtubule Motor protein Nucleotide-binding Reference proteome Transport | MADPAECSIK | MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMF... | anterograde axonal protein transport anterograde dendritic transport of messenger ribonucleoprotein complex anterograde dendritic transport of neurotransmitter receptor complex axon guidance intracellular mRNA localization motor neuron axon guidance mRNA transport organelle organization synaptic vesicle transport axon ... |
cell adhesion cellular response to glucose starvation DNA damage response intracellular signal transduction negative regulation of TOR signaling protein phosphorylation regulation of cell adhesion regulation of cell population proliferation regulation of cellular senescence regulation of myosin-light-chain-phosphatase ... | cytoplasm; fibrillar center; microtubule cytoskeleton; nucleoplasm; nucleotide-activated protein kinase complex; nucleus | ATP binding metal ion binding p53 binding protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | Acetylation Alternative splicing ATP-binding Cell adhesion Cytoplasm DNA damage Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MEGAAAPVAG | MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDAL... | cell adhesion cellular response to glucose starvation DNA damage response intracellular signal transduction negative regulation of TOR signaling protein phosphorylation regulation of cell adhesion regulation of cell population proliferation regulation of cellular senescence regulation of myosin-light-chain-phosphatase ... |
endosome to lysosome transport negative regulation of cAMP-mediated signaling negative regulation of G protein-coupled receptor signaling pathway negative regulation of smoothened signaling pathway protein monoubiquitination protein polyubiquitination protein ubiquitination | cytoplasm; cytosol; early endosome; endoplasmic reticulum; extracellular exosome; intracellular membrane-bounded organelle; membrane; nucleus; plasma membrane | metal ion binding ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | Alternative splicing Cell membrane Cytoplasm Endosome Lipoprotein Membrane Metal-binding Myristate Nucleus Phosphoprotein Reference proteome Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MGSILSRRIA | MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPF... | endosome to lysosome transport negative regulation of cAMP-mediated signaling negative regulation of G protein-coupled receptor signaling pathway negative regulation of smoothened signaling pathway protein monoubiquitination protein polyubiquitination protein ubiquitination cytoplasm; cytosol; early endosome; endoplasm... |
tRNA methylation tRNA modification wybutosine biosynthetic process | cytoplasm | tRNA methyltransferase activity | Homo sapiens | Methyltransferase Reference proteome S-adenosyl-L-methionine Transferase tRNA processing | MGPRSRERRA | MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFILAASRGDTLSHT... | tRNA methylation tRNA modification wybutosine biosynthetic process cytoplasm tRNA methyltransferase activity Homo sapiens Methyltransferase Reference proteome S-adenosyl-L-methionine Transferase tRNA processing MGPRSRERRA MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFR... |
anterograde axonal transport of mitochondrion anterograde dendritic transport of mitochondrion mitochondrion distribution neurogenesis protein targeting vesicle transport along microtubule | axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; early endosome; mitochondrion; plasma membrane | GABA receptor binding myosin binding signaling receptor binding | Homo sapiens | Alternative splicing Coiled coil Cytoplasm Endosome Glycoprotein Mitochondrion Phosphoprotein Reference proteome Transport | MSQSQNAIFT | MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEHVIEKEELKLHLQASKDAQR... | anterograde axonal transport of mitochondrion anterograde dendritic transport of mitochondrion mitochondrion distribution neurogenesis protein targeting vesicle transport along microtubule axon cytoplasm; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; dendrite cytoplasm; early endosome; mitochondrion; plasma membra... |
regulation of transcription by RNA polymerase II | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MATVPGLQPL | MATVPGLQPLPTLEQDLEQEEILIVKVEEDFCLEEEPSVETEDPSPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVLPGEIQARVREQQPESGEEAVVLVEGLQRKPRKHRQRGSELLSDDEVPLGIGGQFLKHQAEAQPEDLSLEEEARFSSQQPPAQLSHRPQRGPLLWPERGPPAPRHQEMASASPFLSAWSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPLENEGPGIQLEDGGDGREDAPLRMEWYRVLSARCQGPGHPLPGQRPAPVRGLVRPDQPRGGPPPGRRASHG... | regulation of transcription by RNA polymerase II nucleus DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Alternative splicing DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcripti... |
apoptotic process axonal transport of mitochondrion cellular senescence GTP metabolic process inner mitochondrial membrane organization membrane tubulation mitochondrial fission mitochondrial fusion mitochondrial genome maintenance mitochondrion organization negative regulation of apoptotic process negative regulation ... | axon cytoplasm; cytoplasm; cytosol; dendrite; membrane; microtubule; mitochondrial crista; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm | cardiolipin binding GTP binding GTPase activity magnesium ion binding microtubule binding phosphatidic acid binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis Cardiomyopathy Coiled coil Deafness Disease variant GTP-binding Hydrolase Lipid-binding Membrane Mitochondrion Mitochondrion inner membrane Neurodegeneration Nucleotide-binding Primary mitochondrial disease Reference proteome Sensory transduction Transit peptide T... | MWRLRRAAVA | MWRLRRAAVACEVCQSLVKHSSGIKGSLPLQKLHLVSRSIYHSHHPTLKLQRPQLRTSFQQFSSLTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDLSEYKWIVPDIVWEIDEYIDFEKIRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSGSPEETAFRATDRGSESDKHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGE... | apoptotic process axonal transport of mitochondrion cellular senescence GTP metabolic process inner mitochondrial membrane organization membrane tubulation mitochondrial fission mitochondrial fusion mitochondrial genome maintenance mitochondrion organization negative regulation of apoptotic process negative regulation ... |
actin cytoskeleton organization adherens junction assembly cell-cell adhesion clathrin-dependent endocytosis membrane organization neutrophil chemotaxis phagocytosis phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process phosphorylation regulation of phosphatidylinositol 3-kinase/... | adherens junction; cytosol; endosome membrane; focal adhesion; nucleoplasm; phagocytic cup; plasma membrane; presynapse; ruffle membrane; uropod | 1-phosphatidylinositol-4-phosphate 5-kinase activity ATP binding phosphatidylinositol kinase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Cell adhesion Cell junction Cell membrane Cell projection Chemotaxis Cytoplasm Disease variant Endocytosis Exocytosis Kinase Lipid metabolism Membrane Methylation Nucleotide-binding Nucleus Phagocytosis Phosphoprotein Reference proteome Transferase | MELEVPDEAE | MELEVPDEAESAEAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGKKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL... | actin cytoskeleton organization adherens junction assembly cell-cell adhesion clathrin-dependent endocytosis membrane organization neutrophil chemotaxis phagocytosis phosphatidylinositol biosynthetic process phosphatidylinositol phosphate biosynthetic process phosphorylation regulation of phosphatidylinositol 3-kinase/... |
ERAD pathway proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination protein ubiquitination ubiquitin-dependent ERAD pathway | endoplasmic reticulum; endoplasmic reticulum membrane; ER ubiquitin ligase complex; membrane | enzyme binding ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity ubiquitin-specific protease binding zinc ion binding | Homo sapiens | Acetylation Alternative splicing Endoplasmic reticulum Epilepsy Membrane Metal-binding Reference proteome Transferase Transmembrane Transmembrane helix Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MDTAEEDICR | MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLG... | ERAD pathway proteasomal protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination protein ubiquitination ubiquitin-dependent ERAD pathway endoplasmic reticulum; endoplasmic reticulum membrane; ER ubiquitin ligase complex; membrane enzyme binding ubiqu... |
canonical Wnt signaling pathway cell proliferation in midbrain embryonic nail plate morphogenesis establishment of body hair planar orientation hair follicle development inner ear morphogenesis midbrain morphogenesis negative regulation of canonical Wnt signaling pathway negative regulation of DNA-binding transcription... | apical plasma membrane; apicolateral plasma membrane; cell surface; cytoplasmic vesicle membrane; endoplasmic reticulum membrane; plasma membrane | G protein-coupled receptor activity ubiquitin protein ligase binding Wnt receptor activity Wnt-protein binding | Homo sapiens | Alternative splicing Cell membrane Cytoplasmic vesicle Developmental protein Disease variant Disulfide bond Endoplasmic reticulum G-protein coupled receptor Glycoprotein Membrane Phosphoprotein Receptor Reference proteome Signal Transducer Transmembrane Transmembrane helix Ubl conjugation Wnt signaling pathway | MEMFTFLLTC | MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQCAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAAGRKWSCEAI... | canonical Wnt signaling pathway cell proliferation in midbrain embryonic nail plate morphogenesis establishment of body hair planar orientation hair follicle development inner ear morphogenesis midbrain morphogenesis negative regulation of canonical Wnt signaling pathway negative regulation of DNA-binding transcription... |
calcium ion transport neurotransmitter receptor internalization neurotransmitter receptor localization to postsynaptic specialization membrane neurotransmitter receptor transport, postsynaptic endosome to lysosome positive regulation of synaptic transmission, glutamatergic postsynaptic neurotransmitter receptor diffusi... | AMPA glutamate receptor complex; dendrite; endocytic vesicle membrane; excitatory synapse; glutamatergic synapse; plasma membrane; postsynaptic density membrane; Schaffer collateral - CA1 synapse; somatodendritic compartment; voltage-gated calcium channel complex | channel regulator activity ionotropic glutamate receptor binding PDZ domain binding voltage-gated calcium channel activity | Homo sapiens | Calcium Calcium channel Calcium transport Ion channel Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel | MRMCDRGIQM | MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKSHSEFLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKITMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV | calcium ion transport neurotransmitter receptor internalization neurotransmitter receptor localization to postsynaptic specialization membrane neurotransmitter receptor transport, postsynaptic endosome to lysosome positive regulation of synaptic transmission, glutamatergic postsynaptic neurotransmitter receptor diffusi... |
regulation of cell cycle regulation of transcription by RNA polymerase II Wnt signaling pathway | chromatin; nuclear speck; nucleoplasm; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Wnt signaling pathway | MVWEVKTNQM | MVWEVKTNQMPNAVQKLLLVMDKRASGMNDSLELLQCNENLPSSPGYNSCDEHMELDDLPELQAVQSDPTQSGMYQLSSDVSHQEYPRSSWNQNTSDIPETTYRENEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSSSKSEPAFPHHHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKGSNKEWQDVEDFARAEGCDNEEDLQMGIHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQ... | regulation of cell cycle regulation of transcription by RNA polymerase II Wnt signaling pathway chromatin; nuclear speck; nucleoplasm; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens 3D-structure... |
female gamete generation negative regulation of cell growth oocyte growth positive regulation of cell population proliferation regulation of progesterone secretion transforming growth factor beta receptor signaling pathway | cytoplasm; extracellular space | cytokine activity growth factor activity | Homo sapiens | Cleavage on pair of basic residues Cytokine Disulfide bond Glycoprotein Growth factor Phosphoprotein Premature ovarian failure Reference proteome Secreted Signal | MARPNKFLLW | MARPNKFLLWFCCFAWLCFPISLGSQASGGEAQIAASAELESGAMPWSLLQHIDERDRAGLLPALFKVLSVGRGGSPRLQPDSRALHYMKKLYKTYATKEGIPKSNRSHLYNTVRLFTPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINNSVSFSSAVKCVCNLMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHKWIQIDVTSLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRG... | female gamete generation negative regulation of cell growth oocyte growth positive regulation of cell population proliferation regulation of progesterone secretion transforming growth factor beta receptor signaling pathway cytoplasm; extracellular space cytokine activity growth factor activity Homo sapiens Cleavage on ... |
oogenesis regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding | Homo sapiens | Alternative splicing Developmental protein Differentiation Disease variant DNA-binding Homeobox Nucleus Oogenesis Premature ovarian failure Reference proteome Transcription Transcription regulation | MALLLTLTSP | MALLLTLTSPDLEGTWDTRDKDGFKAQEGPPLAVPEFPVCGLYRIYGVCGSFSSFFIIRCSLCALETLKSPQHDPLEIPEQSLKLIPLVSGKRELTRGQKAGEKPLAAGPGEEELLRGSAPHAQDTQSEELPPSCTISGEKKPPAVSGEATGADAGRLCPPPRSRAPHKDRTLARSRPQTQGEDCSLPVGEVKIGKRSYSPAPGKQKKPNAMGLAPTSSPGAPNSARATHNPVPCGSGRGPCHLANLLSTLAQSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIMVKG... | oogenesis regulation of transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding Homo sapiens Alternative splicing Developmental protein Differentiation ... |
alpha-linolenic acid metabolic process cell-cell signaling cellular response to starvation icosanoid biosynthetic process linoleic acid metabolic process lipid metabolic process long-chain fatty acid biosynthetic process phospholipid biosynthetic process regulation of cell differentiation regulation of DNA-templated tr... | endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; mitochondrion | acyl-CoA delta5-desaturase activity C-5 sterol desaturase activity linoleoyl-CoA desaturase activity omega-6 fatty acid desaturase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of wate... | Homo sapiens | Acetylation Alternative splicing Electron transport Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Membrane Mitochondrion Oxidoreductase Reference proteome Transmembrane Transmembrane helix Transport | MAPDPVAAET | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVISHYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVERMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHDFGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFALGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMITFYVRFFLTYVPLLGLKAFL... | alpha-linolenic acid metabolic process cell-cell signaling cellular response to starvation icosanoid biosynthetic process linoleic acid metabolic process lipid metabolic process long-chain fatty acid biosynthetic process phospholipid biosynthetic process regulation of cell differentiation regulation of DNA-templated tr... |
cellular response to tumor necrosis factor cellular response to virus inner ear auditory receptor cell differentiation negative regulation of cell population proliferation positive regulation of immune response to tumor cell positive regulation of intrinsic apoptotic signaling pathway positive regulation of MAPK cascad... | cytoplasm; cytosol; membrane; plasma membrane | cardiolipin binding phosphatidylinositol-4,5-bisphosphate binding wide pore channel activity | Homo sapiens | Alternative splicing Cell membrane Cytoplasm Deafness Membrane Necrosis Non-syndromic deafness Reference proteome Transmembrane Transmembrane beta strand Tumor suppressor | MFAKATRNFL | MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLSLTLGDVLIEDQFPSPVVVESDFVKYEGKFANHVSGTLETALGKVKLNLGGSSRVESQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVISEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLLRGKQGGFENKKRIDSVYLDPLVFREFAFIDMPDAAHGISSQDGPLSVLKQATLLLERNFHPFAELPEPQQTALSDIFQAVLFD... | cellular response to tumor necrosis factor cellular response to virus inner ear auditory receptor cell differentiation negative regulation of cell population proliferation positive regulation of immune response to tumor cell positive regulation of intrinsic apoptotic signaling pathway positive regulation of MAPK cascad... |
cell cycle cell division positive regulation of GTPase activity retrograde transport, endosome to Golgi | centrosome; cytosol; nucleus; spindle | GTPase activator activity small GTPase binding | Homo sapiens | Alternative splicing Cell cycle Cell division Chromosomal rearrangement Coiled coil Cytoplasm Cytoskeleton Nucleus Phosphoprotein Reference proteome Ubl conjugation | MVTNKMTAAF | MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYA... | cell cycle cell division positive regulation of GTPase activity retrograde transport, endosome to Golgi centrosome; cytosol; nucleus; spindle GTPase activator activity small GTPase binding Homo sapiens Alternative splicing Cell cycle Cell division Chromosomal rearrangement Coiled coil Cytoplasm Cytoskeleton Nucleus Pho... |
angiogenesis axon extension involved in axon guidance axon guidance branchiomotor neuron axon guidance cell adhesion cellular response to leukemia inhibitory factor dorsal root ganglion morphogenesis facial nerve structural organization facioacoustic ganglion development gonadotrophin-releasing hormone neuronal migrati... | axon; extracellular region; glutamatergic synapse; membrane; plasma membrane; postsynaptic membrane; semaphorin receptor complex | cytokine binding growth factor binding heparin binding identical protein binding metal ion binding semaphorin receptor activity signaling receptor activity vascular endothelial growth factor receptor activity | Homo sapiens | 3D-structure Alternative splicing Calcium Developmental protein Differentiation Disulfide bond Glycoprotein Heparin-binding Host-virus interaction Membrane Metal-binding Neurogenesis Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix | MDMFPLTWVF | MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTP... | angiogenesis axon extension involved in axon guidance axon guidance branchiomotor neuron axon guidance cell adhesion cellular response to leukemia inhibitory factor dorsal root ganglion morphogenesis facial nerve structural organization facioacoustic ganglion development gonadotrophin-releasing hormone neuronal migrati... |
carbohydrate metabolic process lung alveolus development N-glycan processing protein glycosylation respiratory gaseous exchange by respiratory system | endoplasmic reticulum; extracellular exosome; Golgi apparatus; Golgi membrane; membrane | calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity | Homo sapiens | Acetylation Calcium Disulfide bond Glycoprotein Glycosidase Golgi apparatus Hydrolase Membrane Metal-binding Reference proteome Signal-anchor Transmembrane Transmembrane helix | MTTPALLPLS | MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVFLIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEEIFKIKAVQLAEKLLPAFNTPTGIPWAMVNLKSGVG... | carbohydrate metabolic process lung alveolus development N-glycan processing protein glycosylation respiratory gaseous exchange by respiratory system endoplasmic reticulum; extracellular exosome; Golgi apparatus; Golgi membrane; membrane calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Homo s... |
blood vessel development BMP signaling pathway epithelial cell differentiation gene expression hair cell differentiation hair follicle cell proliferation hair follicle morphogenesis odontoblast differentiation odontogenesis of dentin-containing tooth placenta development positive regulation of transcription by RNA poly... | chromatin; cytoplasm; nucleus | chromatin binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded D... | Homo sapiens | 3D-structure Activator Amelogenesis imperfecta Cytoplasm Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSGSFDRKLS | MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY | blood vessel development BMP signaling pathway epithelial cell differentiation gene expression hair cell differentiation hair follicle cell proliferation hair follicle morphogenesis odontoblast differentiation odontogenesis of dentin-containing tooth placenta development positive regulation of transcription by RNA poly... |
embryonic process involved in female pregnancy fatty acid metabolic process lipid biosynthetic process lipid metabolic process long-chain fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA metabolic process negative regulation of prostaglandin secretion neuron differen... | cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular exosome; lipid droplet; membrane; mitochondria-associated endoplasmic reticulum membrane; mitochondrial outer membrane; peroxisomal membrane; plasma membrane | arachidonate-CoA ligase activity ATP binding long-chain fatty acid-CoA ligase activity palmitoyl-CoA ligase activity very long-chain fatty acid-CoA ligase activity | Homo sapiens | Alport syndrome Alternative splicing ATP-binding Cell membrane Deafness Disease variant Elliptocytosis Endoplasmic reticulum Fatty acid metabolism Hereditary hemolytic anemia Intellectual disability Ligase Lipid metabolism Magnesium Membrane Microsome Mitochondrion Mitochondrion outer membrane Nucleotide-binding Peroxi... | MKLKLNVLTI | MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVSKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWMNYLEVNRRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAVVHGLNESEASYLITSVELLESKLKTALLDISCVKHIIYVDNKAINKAEYPEGFEIHSMQSVEELGSNPENLGIPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLP... | embryonic process involved in female pregnancy fatty acid metabolic process lipid biosynthetic process lipid metabolic process long-chain fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA metabolic process negative regulation of prostaglandin secretion neuron differen... |
endocytic recycling intralumenal vesicle formation late endosome to Golgi transport membrane invagination negative regulation of early endosome to late endosome transport negative regulation of phagocytosis negative regulation of protein catabolic process negative regulation of protein transport negative regulation of ... | clathrin-coated vesicle; cytoplasm; cytosol; early endosome; early endosome membrane; early phagosome; endosome membrane; extracellular exosome; retromer complex | phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-3-phosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding protein phosphatase binding retromer complex binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chromosomal rearrangement Cytoplasmic vesicle Direct protein sequencing Endosome Isopeptide bond Lipid-binding Methylation Microphthalmia Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation | MAETVADTRR | MAETVADTRRLITKPQNLNDAYGPPSNFLEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWLRSELERESKVVVPPLPGKAFLRQLPFRGDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKSYTPSKIRHA | endocytic recycling intralumenal vesicle formation late endosome to Golgi transport membrane invagination negative regulation of early endosome to late endosome transport negative regulation of phagocytosis negative regulation of protein catabolic process negative regulation of protein transport negative regulation of ... |
cell surface receptor signaling pathway positive regulation of MAPK cascade Ras protein signal transduction signal transduction transmembrane receptor protein tyrosine kinase signaling pathway | cytoplasm; cytosol | transmembrane receptor protein tyrosine kinase adaptor activity | Homo sapiens | 3D-structure Direct protein sequencing Host-virus interaction Phosphoprotein Reference proteome | MGDGAVKQGF | MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVIRLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKELSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLRGSYTLRAGESALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHDSLPPPSPTTPVPAPRPRGQEGEYAVPFDAVARSLGKNFRGILAV... | cell surface receptor signaling pathway positive regulation of MAPK cascade Ras protein signal transduction signal transduction transmembrane receptor protein tyrosine kinase signaling pathway cytoplasm; cytosol transmembrane receptor protein tyrosine kinase adaptor activity Homo sapiens 3D-structure Direct protein seq... |
Golgi vesicle transport intracellular protein transport regulation of protein localization retrograde transport, endosome to Golgi vesicle docking vesicle fusion | cytosol; endomembrane system; Golgi membrane; perinuclear region of cytoplasm; SNARE complex; trans-Golgi network; trans-Golgi network membrane; vesicle | SNAP receptor activity SNARE binding syntaxin binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Coiled coil Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MSLEDPFFVV | MSLEDPFFVVRGEVQKAVNTARGLYQRWCELLQESAAVGREELDWTTNELRNGLRSIEWDLEDLEETIGIVEANPGKFKLPAGDLQERKVFVERMREAVQEMKDHMVSPTAVAFLERNNREILAGKPAAQKSPSDLLDASAVSATSRYIEEQQATQQLIMDEQDQQLEMVSGSIQVLKHMSGRVGEELDEQGIMLDAFAQEMDHTQSRMDGVLRKLAKVSHMTSDRRQWCAIAVLVGVLLLVLILLFSL | Golgi vesicle transport intracellular protein transport regulation of protein localization retrograde transport, endosome to Golgi vesicle docking vesicle fusion cytosol; endomembrane system; Golgi membrane; perinuclear region of cytoplasm; SNARE complex; trans-Golgi network; trans-Golgi network membrane; vesicle SNAP ... |
glycoprotein catabolic process glycoprotein metabolic process N-acetylglucosamine metabolic process protein deglycosylation protein O-linked glycosylation | cytosol; membrane; nucleus | -3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity -3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity -3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity beta-N-acetylglucosaminidase activity hyalurononglucosamini... | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Glycosidase Host-virus interaction Hydrolase Nucleus Phosphoprotein Reference proteome | MVQKESQATL | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEA... | glycoprotein catabolic process glycoprotein metabolic process N-acetylglucosamine metabolic process protein deglycosylation protein O-linked glycosylation cytosol; membrane; nucleus -3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity -3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-... |
cell adhesion cell-substrate adhesion MAPK cascade negative regulation of transcription by RNA polymerase II positive regulation of cytoskeleton organization positive regulation of MAPK cascade positive regulation of stress fiber assembly | cell-substrate junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleus | structural constituent of cytoskeleton vinculin binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell adhesion Cell junction Cytoplasm Cytoskeleton Nucleus Phosphoprotein Reference proteome Repeat SH3 domain | MQGPPRSLRA | MQGPPRSLRAGLSLDDFIPGHLQSHIGSSSRGTRVPVIRNGGSNTLNFQFHDPAPRTVCNGGYTPRRDASQHPDPAWYQTWPGPGSKPSASTKIPASQHTQNWSATWTKDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAGPAS... | cell adhesion cell-substrate adhesion MAPK cascade negative regulation of transcription by RNA polymerase II positive regulation of cytoskeleton organization positive regulation of MAPK cascade positive regulation of stress fiber assembly cell-substrate junction; cytoplasm; cytoskeleton; cytosol; focal adhesion; nucleu... |
cellular response to type II interferon CRD-mediated mRNA stabilization mRNA modification mRNA splicing, via spliceosome negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative re... | catalytic step 2 spliceosome; CRD-mediated mRNA stability complex; cytosol; endoplasmic reticulum; GAIT complex; histone pre-mRNA 3'end processing complex; mCRD-mediated mRNA stability complex; membrane; mRNA editing complex; nucleoplasm; nucleus; ribonucleoprotein complex | mRNA 5'-UTR binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Endoplasmic reticulum Host-virus interaction Isopeptide bond Methylation Microsome mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ribonucleoprotein RNA-binding Spliceosome Translation regulation Ubl conjuga... | MATEHVNGNG | MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTV... | cellular response to type II interferon CRD-mediated mRNA stabilization mRNA modification mRNA splicing, via spliceosome negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay negative re... |
3'-phosphoadenosine 5'-phosphosulfate metabolic process inflammatory response peptidyl-tyrosine sulfation | Golgi apparatus; Golgi membrane; membrane | protein homodimerization activity protein-tyrosine sulfotransferase activity | Homo sapiens | 3D-structure Disulfide bond Glycoprotein Golgi apparatus Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MVGKLKQNLL | MVGKLKQNLLLACLVISSVTVFYLGQHAMECHHRIEERSQPVKLESTRTTVRTGLDLKANKTFAYHKDMPLIFIGGVPRSGTTLMRAMLDAHPDIRCGEETRVIPRILALKQMWSRSSKEKIRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPAPYLCNKDPFALKSLTYLSRLFPNAKFLLMVRDGRASVHSMISRKVTIAGFDLNSYRDCLTKWNRAIETMYNQCMEVGYKKCMLVHYEQLVLHPERWMRTLLKFLQIPWNHSVLHHEEMIGKAGGVSLSKVERSTDQVIKPVNVGALSKWVGKIPPDVLQDMAVIAPM... | 3'-phosphoadenosine 5'-phosphosulfate metabolic process inflammatory response peptidyl-tyrosine sulfation Golgi apparatus; Golgi membrane; membrane protein homodimerization activity protein-tyrosine sulfotransferase activity Homo sapiens 3D-structure Disulfide bond Glycoprotein Golgi apparatus Membrane Reference proteo... |
embryonic brain development mRNA splicing, via spliceosome | catalytic step 2 spliceosome; nuclear speck; nucleoplasm; U2-type catalytic step 2 spliceosome | mRNA binding RNA binding | Homo sapiens | 3D-structure Disease variant Intellectual disability mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Spliceosome WD repeat | MSAAIAALAA | MSAAIAALAASYGSGSGSESDSDSESSRCPLPAADSLMHLTKSPSSKPSLAVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYG... | embryonic brain development mRNA splicing, via spliceosome catalytic step 2 spliceosome; nuclear speck; nucleoplasm; U2-type catalytic step 2 spliceosome mRNA binding RNA binding Homo sapiens 3D-structure Disease variant Intellectual disability mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Rep... |
carbohydrate metabolic process galactosylceramide biosynthetic process glycosylation protein glycosylation | cytosol; extracellular exosome; Golgi apparatus; Golgi cisterna membrane; Golgi membrane | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity galactosyltransferase activity metal ion binding N-acetyllactosamine synthase activity | Homo sapiens | Alternative splicing Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MLRRLLERPC | MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMN... | carbohydrate metabolic process galactosylceramide biosynthetic process glycosylation protein glycosylation cytosol; extracellular exosome; Golgi apparatus; Golgi cisterna membrane; Golgi membrane beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity galactosyltransferase activity metal ion bindi... |
carbohydrate metabolic process glycosylation keratan sulfate biosynthetic process lactosylceramide biosynthetic process membrane lipid metabolic process protein glycosylation | extracellular region; Golgi apparatus; Golgi membrane; membrane | galactosyltransferase activity metal ion binding N-acetyllactosamine synthase activity UDP-galactosyltransferase activity | Homo sapiens | Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Manganese Membrane Metal-binding Reference proteome Secreted Signal-anchor Transferase Transmembrane Transmembrane helix | MGFNLTFHLS | MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKGKTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKALQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLEALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSREQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAERMKLLHQVSRVWRTDGLSSC... | carbohydrate metabolic process glycosylation keratan sulfate biosynthetic process lactosylceramide biosynthetic process membrane lipid metabolic process protein glycosylation extracellular region; Golgi apparatus; Golgi membrane; membrane galactosyltransferase activity metal ion binding N-acetyllactosamine synthase act... |
negative regulation of translational initiation | cytoplasm; eukaryotic translation initiation factor 4F complex; membrane; nucleus | eukaryotic initiation factor 4E binding translation repressor activity | Homo sapiens | Cytoplasm Nucleus Phosphoprotein Protein synthesis inhibitor Reference proteome Translation regulation | MSTSTSCPIP | MSTSTSCPIPGGRDQLPDCYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCCLPQIPGVTTPPTAPLSKLEELKEQETEEEIPDDAQFEMDI | negative regulation of translational initiation cytoplasm; eukaryotic translation initiation factor 4F complex; membrane; nucleus eukaryotic initiation factor 4E binding translation repressor activity Homo sapiens Cytoplasm Nucleus Phosphoprotein Protein synthesis inhibitor Reference proteome Translation regulation MST... |
cell cycle cell differentiation DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of fat cell differentiation positive regulation of glucose import positive regulation of lipid biosynthetic process positive regulation of peptidyl-serine phosphorylation protein stabilizat... | chromatin; nucleus | DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific | Homo sapiens | Activator Cell cycle Differentiation DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Tumor suppressor | MDDSKVVGGK | MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW | cell cycle cell differentiation DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of fat cell differentiation positive regulation of glucose import positive regulation of lipid biosynthetic process positive regulation of peptidyl-serine phosphorylation protein stabilizat... |
apoptotic process cellular response to cold lipid droplet fusion lipid metabolic process lipid storage negative regulation of cold-induced thermogenesis negative regulation of cytokine production negative regulation of execution phase of apoptosis negative regulation of lipid catabolic process negative regulation of tr... | cytoplasm; cytosol; lipid droplet; mitochondrial envelope; mitochondrion; nucleus | lipid transfer activity phosphatidic acid binding protein homodimerization activity | Homo sapiens | 3D-structure Activator Apoptosis Lipid droplet Nucleus Reference proteome Transcription Transcription regulation | MEAARDYAGA | MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG | apoptotic process cellular response to cold lipid droplet fusion lipid metabolic process lipid storage negative regulation of cold-induced thermogenesis negative regulation of cytokine production negative regulation of execution phase of apoptosis negative regulation of lipid catabolic process negative regulation of tr... |
de novo' GDP-L-fucose biosynthetic process GDP-mannose metabolic process Notch signaling pathway | cytoplasm; cytosol; extracellular exosome | GDP-mannose 4,6-dehydratase activity identical protein binding NADP+ binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Lyase NADP Phosphoprotein Reference proteome | MAHAPARCPS | MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVD... | de novo' GDP-L-fucose biosynthetic process GDP-mannose metabolic process Notch signaling pathway cytoplasm; cytosol; extracellular exosome GDP-mannose 4,6-dehydratase activity identical protein binding NADP+ binding Homo sapiens 3D-structure Acetylation Alternative splicing Lyase NADP Phosphoprotein Reference proteome ... |
anatomical structure morphogenesis cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded D... | Homo sapiens | DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MTLGSCCCEI | MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGELPARSGPRAPRDVLPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPP... | anatomical structure morphogenesis cell differentiation positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcripti... |
intracellular transport of virus N-terminal peptidyl-glycine N-myristoylation regulation of rhodopsin mediated signaling pathway | cytoplasm; cytosol; Golgi apparatus; host cell; plasma membrane | glycylpeptide N-tetradecanoyltransferase activity peptidyl-lysine N6-myristoyltransferase activity | Homo sapiens | 3D-structure Acyltransferase Cytoplasm Membrane Phosphoprotein Reference proteome Transferase | MAEDSESAAS | MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNM... | intracellular transport of virus N-terminal peptidyl-glycine N-myristoylation regulation of rhodopsin mediated signaling pathway cytoplasm; cytosol; Golgi apparatus; host cell; plasma membrane glycylpeptide N-tetradecanoyltransferase activity peptidyl-lysine N6-myristoyltransferase activity Homo sapiens 3D-structure Ac... |
cell cycle cell division positive regulation by host of viral transcription positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II regulation of cyclin-dependent protein serine/threonin... | cyclin/CDK positive transcription elongation factor complex; cytosol; nucleoplasm; nucleus; P-TEFb complex | 7SK snRNA binding chromatin binding cyclin-dependent protein serine/threonine kinase activator activity DNA binding DNA-binding transcription factor binding molecular condensate scaffold activity protein kinase binding RNA polymerase binding transcription cis-regulatory region binding | Homo sapiens | 3D-structure Acetylation ADP-ribosylation Alternative splicing Cell cycle Cell division Coiled coil Cyclin Direct protein sequencing Host-virus interaction Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MEGERKNNNK | MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESS... | cell cycle cell division positive regulation by host of viral transcription positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II regulation of cyclin-dependent protein serine/threonin... |
basement membrane assembly collagen fibril organization collagen metabolic process endothelial cell morphogenesis epidermis morphogenesis hydroxylysine biosynthetic process in utero embryonic development lung morphogenesis neural tube development peptidyl-lysine hydroxylation protein localization protein O-linked glyco... | collagen-containing extracellular matrix; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular exosome; extracellular space; Golgi apparatus; rough endoplasmic reticulum; trans-Golgi network | iron ion binding L-ascorbic acid binding metal ion binding procollagen galactosyltransferase activity procollagen glucosyltransferase activity procollagen-lysine 5-dioxygenase activity small molecule binding | Homo sapiens | 3D-structure Dioxygenase Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Glycosyltransferase Iron Manganese Membrane Metal-binding Multifunctional enzyme Oxidoreductase Reference proteome Secreted Signal Transferase Vitamin C | MTSSGPGPRF | MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLL... | basement membrane assembly collagen fibril organization collagen metabolic process endothelial cell morphogenesis epidermis morphogenesis hydroxylysine biosynthetic process in utero embryonic development lung morphogenesis neural tube development peptidyl-lysine hydroxylation protein localization protein O-linked glyco... |
miRNA-mediated gene silencing by inhibition of translation negative regulation of translation negative regulation of translational initiation negative regulation of type I interferon-mediated signaling pathway rescue of stalled ribosome | cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; P-body | mRNA cap binding RNA 7-methylguanosine cap binding RNA binding RNA cap binding translation factor activity, RNA binding translation initiation factor activity ubiquitin protein ligase binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Reference proteome RNA-binding RNA-mediated gene silencing Translation regulation Ubl conjugation | MNNKFDALKD | MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTERDKNQSSSKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKPRLNVP | miRNA-mediated gene silencing by inhibition of translation negative regulation of translation negative regulation of translational initiation negative regulation of type I interferon-mediated signaling pathway rescue of stalled ribosome cytoplasm; cytosol; eukaryotic translation initiation factor 4F complex; P-body mRN... |
cell cycle cell division early viral transcription late viral transcription positive regulation by host of viral transcription positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II reg... | cyclin/CDK positive transcription elongation factor complex; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane | 7SK snRNA binding chromatin binding cyclin-dependent protein serine/threonine kinase activator activity protein kinase binding RNA polymerase binding transcription coactivator binding | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Cyclin Cytoplasm Host-virus interaction Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MASGRGASSR | MASGRGASSRWFFTREQLENTPSRRCGVEADKELSCRQQAANLIQEMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNKNIISSTALFLAAKVEEQARKLEHVIKVAHACLHPLEPLLDTKCDAYLQQTQELVILETIMLQTLGFEITIEHPHTDVVKCTQLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGKHWWEYVDPTVTLELLDELTHEFLQILEKTPNRLKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNI... | cell cycle cell division early viral transcription late viral transcription positive regulation by host of viral transcription positive regulation of DNA-templated transcription, elongation positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II reg... |
cellular response to mechanical stimulus inflammatory response innate immune response positive regulation of interleukin-8 production toll-like receptor 5 signaling pathway toll-like receptor signaling pathway | plasma membrane | interleukin-1 receptor binding pattern recognition receptor activity signaling receptor activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Cell membrane Direct protein sequencing Disulfide bond Glycoprotein Immunity Inflammatory response Innate immunity Leucine-rich repeat Membrane Phosphoprotein Receptor Reference proteome Repeat Signal Systemic lupus erythematosus Transmembrane Transmembrane helix | MGDHLDLLLG | MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLA... | cellular response to mechanical stimulus inflammatory response innate immune response positive regulation of interleukin-8 production toll-like receptor 5 signaling pathway toll-like receptor signaling pathway plasma membrane interleukin-1 receptor binding pattern recognition receptor activity signaling receptor activi... |
nervous system development neuron migration peripheral nervous system development signal transduction sympathetic nervous system development | cytosol; external side of plasma membrane; extrinsic component of membrane; plasma membrane; receptor complex | axon guidance receptor activity signaling receptor activity signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Glycoprotein GPI-anchor Lipoprotein Membrane Receptor Reference proteome Signal | MVRPLNPRPL | MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEEPSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGPHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAPNDRGCGERRRNTIAPNCALPPVAPNCLELRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFVSNVNTSVALSCTCRG... | nervous system development neuron migration peripheral nervous system development signal transduction sympathetic nervous system development cytosol; external side of plasma membrane; extrinsic component of membrane; plasma membrane; receptor complex axon guidance receptor activity signaling receptor activity signaling... |
de novo' post-translational protein folding sperm DNA condensation | endoplasmic reticulum lumen | oxidoreductase activity selenium binding thioredoxin peroxidase activity | Homo sapiens | Alternative splicing Direct protein sequencing Endoplasmic reticulum Reference proteome Selenocysteine Signal | MVAMAAGPSG | MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI | de novo' post-translational protein folding sperm DNA condensation endoplasmic reticulum lumen oxidoreductase activity selenium binding thioredoxin peroxidase activity Homo sapiens Alternative splicing Direct protein sequencing Endoplasmic reticulum Reference proteome Selenocysteine Signal MVAMAAGPSG MVAMAAGPSGCLVPAFGL... |
clathrin coat assembly clathrin-dependent endocytosis protein transport regulation of clathrin-dependent endocytosis synaptic vesicle budding from presynaptic endocytic zone membrane | clathrin-coated pit; clathrin-coated vesicle; extrinsic component of presynaptic endocytic zone membrane; synaptic vesicle | 1-phosphatidylinositol binding clathrin heavy chain binding phosphatidylinositol-4,5-bisphosphate binding protein kinase binding SNARE binding | Homo sapiens | Alternative splicing Cell membrane Coated pit Glycoprotein Membrane Methylation Phosphoprotein Protein transport Reference proteome Transport | MSGQTLTDRI | MSGQTLTDRIAAAQYSVTGSAVARAVCKATTHEVMGPKKKHLDYLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTTHHLMVHGNERFIQYLASRNTLFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQMAFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLFKDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDKGDIPDLTQAPSSLMETLEQHLNTLEGKKPGNNEGSGAPSPLSKSSPATTVTSPNSTPAK... | clathrin coat assembly clathrin-dependent endocytosis protein transport regulation of clathrin-dependent endocytosis synaptic vesicle budding from presynaptic endocytic zone membrane clathrin-coated pit; clathrin-coated vesicle; extrinsic component of presynaptic endocytic zone membrane; synaptic vesicle 1-phosphatidyl... |
exocyst localization exocytosis membrane fission mitotic cytokinesis protein transport vesicle docking involved in exocytosis vesicle tethering involved in exocytosis | cytosol; exocyst; Golgi apparatus; growth cone; midbody; perinuclear region of cytoplasm; presynaptic membrane; secretory granule membrane | cadherin binding SNARE binding | Homo sapiens | Acetylation Cell projection Cytoplasm Exocytosis Golgi apparatus Protein transport Reference proteome Transport | MKETDREAVA | MKETDREAVATAVQRVAGMLQRPDQLDKVEQYRRREARKKASVEARLKAAIQSQLDGVRTGLSQLHNALNDVKDIQQSLADVSKDWRQSINTIESLKDVKDAVVQHSQLAAAVENLKNIFSVPEIVRETQDLIEQGALLQAHRKLMDLECSRDGLMYEQYRMDSGNTRDMTLIHGYFGSTQGLSDELAKQLWMVLQRSLVTVRRDPTLLVSVVRIIEREEKIDRRILDRKKQTGFVPPGRPKNWKEKMFTILERTVTTRIEGTQADTRESDKMWLVRHLEIIRKYVLDDLIVAKNLMVQCFPPHYEIFKNLLNMYHQALS... | exocyst localization exocytosis membrane fission mitotic cytokinesis protein transport vesicle docking involved in exocytosis vesicle tethering involved in exocytosis cytosol; exocyst; Golgi apparatus; growth cone; midbody; perinuclear region of cytoplasm; presynaptic membrane; secretory granule membrane cadherin bindi... |
cellular glucuronidation flavone metabolic process flavonoid glucuronidation liver development negative regulation of cellular glucuronidation negative regulation of fatty acid metabolic process negative regulation of glucuronosyltransferase activity retinoic acid metabolic process xenobiotic glucuronidation xenobiotic... | endoplasmic reticulum; endoplasmic reticulum membrane | enzyme binding enzyme inhibitor activity glucuronosyltransferase activity protein heterodimerization activity protein homodimerization activity retinoic acid binding | Homo sapiens | Alternative splicing Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Membrane Reference proteome Signal Transferase Transmembrane Transmembrane helix | MACTGWTSPL | MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIA... | cellular glucuronidation flavone metabolic process flavonoid glucuronidation liver development negative regulation of cellular glucuronidation negative regulation of fatty acid metabolic process negative regulation of glucuronosyltransferase activity retinoic acid metabolic process xenobiotic glucuronidation xenobiotic... |
cAMP catabolic process cellular response to epidermal growth factor stimulus positive regulation of ERK1 and ERK2 cascade regulation of DNA-templated transcription signal transduction | cytosol; extracellular exosome | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity kinase binding metal ion binding protein kinase activator activity | Homo sapiens | 3D-structure Alternative splicing cAMP Hydrolase Metal-binding Phosphoprotein Reference proteome | MGCAPSIHIS | MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYV... | cAMP catabolic process cellular response to epidermal growth factor stimulus positive regulation of ERK1 and ERK2 cascade regulation of DNA-templated transcription signal transduction cytosol; extracellular exosome 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity kinase binding me... |
dopaminergic neuron differentiation dorsal/ventral pattern formation neuron differentiation positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Alternative splicing Developmental protein Disease variant DNA-binding Homeobox LIM domain Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc | MDIATGPESL | MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGVLLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIV... | dopaminergic neuron differentiation dorsal/ventral pattern formation neuron differentiation positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription factor activity DNA-binding transc... |
cellular response to glucose starvation lipid droplet disassembly lipid storage positive regulation of sequestering of triglyceride vesicle-mediated transport | cytoplasm; cytosol; endosome; endosome membrane; Golgi apparatus; lipid droplet; membrane; transport vesicle | cadherin binding | Homo sapiens | Acetylation Alternative splicing Coiled coil Cytoplasm Endosome Isopeptide bond Lipid droplet Membrane Phosphoprotein Reference proteome Transport Ubl conjugation | MSADGAEADG | MSADGAEADGSTQVTVEEPVQQPSVVDRVASMPLISSTCDMVSAAYASTKESYPHIKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDKLEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQVLSLMETVKQGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPE... | cellular response to glucose starvation lipid droplet disassembly lipid storage positive regulation of sequestering of triglyceride vesicle-mediated transport cytoplasm; cytosol; endosome; endosome membrane; Golgi apparatus; lipid droplet; membrane; transport vesicle cadherin binding Homo sapiens Acetylation Alternativ... |
cellular defense response Fc receptor-mediated immune complex endocytosis humoral immune response mediated by circulating immunoglobulin immunoglobulin transcytosis in epithelial cells negative regulation of apoptotic process regulation of B cell receptor signaling pathway | early endosome membrane; extracellular region; lysosomal membrane; plasma membrane; trans-Golgi network membrane | high-affinity IgM receptor activity IgM binding polymeric immunoglobulin binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Endosome Golgi apparatus Immunity Immunoglobulin domain Lysosome Membrane Phosphoprotein Reference proteome Secreted Signal Transmembrane Transmembrane helix | MDFWLWPLYF | MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLPEMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLKQYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKVTLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSSKFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSVAGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHRQRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKRAVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNNIYSACPR... | cellular defense response Fc receptor-mediated immune complex endocytosis humoral immune response mediated by circulating immunoglobulin immunoglobulin transcytosis in epithelial cells negative regulation of apoptotic process regulation of B cell receptor signaling pathway early endosome membrane; extracellular region;... |
lactate transmembrane transport monocarboxylic acid transport plasma membrane lactate transport pyruvate transmembrane transport transport across blood-brain barrier | basolateral plasma membrane; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; nucleoplasm; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density membrane; Schaffer collateral - CA1 synapse | identical protein binding lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity pyruvate secondary active transmembrane transporter activity pyruvate transmembrane transporter activity symporter activity | Homo sapiens | 3D-structure Cell membrane Cytoplasm Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport | MPPMPSAPPV | MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFA... | lactate transmembrane transport monocarboxylic acid transport plasma membrane lactate transport pyruvate transmembrane transport transport across blood-brain barrier basolateral plasma membrane; cytosol; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; nucleoplasm; parallel fiber to Purkinje cell synapse;... |
cellular response to ionizing radiation DNA damage checkpoint signaling DNA damage response DNA repair meiotic recombination checkpoint signaling substantia nigra development | checkpoint clamp complex; chromosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus | 3'-5' exonuclease activity damaged DNA binding double-stranded DNA 3'-5' DNA exonuclease activity | Homo sapiens | 3D-structure Alternative splicing DNA damage DNA repair Nucleus Reference proteome | MPLLTQQIQD | MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES | cellular response to ionizing radiation DNA damage checkpoint signaling DNA damage response DNA repair meiotic recombination checkpoint signaling substantia nigra development checkpoint clamp complex; chromosome; intracellular membrane-bounded organelle; nucleoplasm; nucleus 3'-5' exonuclease activity damaged DNA bindi... |
negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding transcription cis-regulatory region... | Homo sapiens | DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MTTNPKPNKA | MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS | negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transc... |
methylation negative regulation of protein ubiquitination negative regulation of retinoic acid biosynthetic process | cytoplasm; cytosol; nucleus | metal ion binding methyltransferase activity protein-arginine N-methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity protein-arginine omega-N monomethyltransferase activity ribosome binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Metal-binding Methyltransferase Phosphoprotein Reference proteome S-adenosyl-L-methionine Transferase Zinc Zinc-finger | MCSLASGATG | MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPV... | methylation negative regulation of protein ubiquitination negative regulation of retinoic acid biosynthetic process cytoplasm; cytosol; nucleus metal ion binding methyltransferase activity protein-arginine N-methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity protein-arginine omega... |
branchiomeric skeletal muscle development cardiac conduction system development cellular response to leukemia inhibitory factor diaphragm development regulation of DNA-templated transcription regulation of transcription by RNA polymerase II roof of mouth development skeletal muscle tissue development | chromatin; nucleoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription reg... | Homo sapiens | DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation | MSTGSVSDPE | MSTGSVSDPEEMELRGLQREYPVPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGSAEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNLTWPFVVSGRPDSDTKEVSAANRLCGTTA | branchiomeric skeletal muscle development cardiac conduction system development cellular response to leukemia inhibitory factor diaphragm development regulation of DNA-templated transcription regulation of transcription by RNA polymerase II roof of mouth development skeletal muscle tissue development chromatin; nucleop... |
cellular response to reactive oxygen species peroxisome organization proteasome-mediated ubiquitin-dependent protein catabolic process protein import into peroxisome matrix protein import into peroxisome matrix, receptor recycling protein import into peroxisome matrix, substrate release protein polyubiquitination prote... | peroxisomal membrane; peroxisome | protein transmembrane transporter activity ubiquitin protein ligase activity zinc ion binding | Homo sapiens | Alternative splicing Disease variant Membrane Metal-binding Peroxisome Peroxisome biogenesis Peroxisome biogenesis disorder Protein transport Reference proteome Transferase Transmembrane Transmembrane helix Transport Ubl conjugation pathway Zellweger syndrome Zinc Zinc-finger | MAPAAASPPE | MAPAAASPPEVIRAAQKDEYYRGGLRSAAGGALHSLAGARKWLEWRKEVELLSDVAYFGLTTLAGYQTLGEEYVSIIQVDPSRIHVPSSLRRGVLVTLHAVLPYLLDKALLPLEQELQADPDSGRPLQGSLGPGGRGCSGARRWMRHHTATLTEQQRRALLRAVFVLRQGLACLQRLHVAWFYIHGVFYHLAKRLTGITYLRVRSLPGEDLRARVSYRLLGVISLLHLVLSMGLQLYGFRQRQRARKEWRLHRGLSHRRASLEERAVSRNPLCTLCLEERRHPTATPCGHLFCWECITAWCSSKAECPLCREKFPPQKLI... | cellular response to reactive oxygen species peroxisome organization proteasome-mediated ubiquitin-dependent protein catabolic process protein import into peroxisome matrix protein import into peroxisome matrix, receptor recycling protein import into peroxisome matrix, substrate release protein polyubiquitination prote... |
entry of viral genome into host nucleus through nuclear pore complex via importin maternal process involved in female pregnancy NLS-bearing protein import into nucleus positive regulation of cytokine production involved in inflammatory response positive regulation of transcription by RNA polymerase II positive regulati... | cytosol; host cell; membrane; NLS-dependent protein nuclear import complex; nucleoplasm; nucleus | nuclear import signal receptor activity nuclear localization sequence binding | Homo sapiens | 3D-structure Acetylation Host-virus interaction Phosphoprotein Protein transport Reference proteome Repeat Transport | METMASPGKD | METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGN... | entry of viral genome into host nucleus through nuclear pore complex via importin maternal process involved in female pregnancy NLS-bearing protein import into nucleus positive regulation of cytokine production involved in inflammatory response positive regulation of transcription by RNA polymerase II positive regulati... |
angiogenesis cell motility cell-cell adhesion positive regulation of cell migration involved in sprouting angiogenesis positive regulation of synapse assembly regulation of phosphorylation vocalization behavior | cell surface; collagen-containing extracellular matrix; cytoplasm; excitatory synapse; extracellular space; synaptic membrane | hepatocyte growth factor binding identical protein binding signaling receptor binding | Homo sapiens | Angiogenesis Cell adhesion Cytoplasm Disease variant Disulfide bond Epilepsy Glycoprotein Intellectual disability Proteoglycan Reference proteome Repeat Secreted Signal Sushi Synapse | MASQLTQRGA | MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICA... | angiogenesis cell motility cell-cell adhesion positive regulation of cell migration involved in sprouting angiogenesis positive regulation of synapse assembly regulation of phosphorylation vocalization behavior cell surface; collagen-containing extracellular matrix; cytoplasm; excitatory synapse; extracellular space; s... |
carbohydrate metabolic process chondroitin sulfate biosynthetic process gastrulation with mouth forming second glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process neuron development protein hexamerization UDP-glucuronate biosynthetic process | cytosol; extracellular exosome; nucleoplasm; nucleus | identical protein binding NAD binding UDP-glucose 6-dehydrogenase activity | Homo sapiens | 3D-structure Acetylation Allosteric enzyme Alternative splicing Carbohydrate metabolism Disease variant Epilepsy NAD Oxidoreductase Phosphoprotein Reference proteome | MFEIKKICCI | MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIID... | carbohydrate metabolic process chondroitin sulfate biosynthetic process gastrulation with mouth forming second glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process neuron development protein hexamerization UDP-glucuronate biosynthetic process cytosol; extracellular exosome; nucleopla... |
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