source_doi stringlengths 13 57 | source_mag_paper_id int64 490k 157M | source_abstract stringlengths 8 10.7k | target_doi stringlengths 14 27 | target_summary stringlengths 42 889 |
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10.1111/1365-2664.13905 | 38,473,814 | Abstract About half of the world's tropical peatlands occur in Southeast (SE) Asia, where they serve as a major carbon (C) sink. Nearly 80% of natural peatlands in this region have been deforested and drained, with the majority under plantations and agriculture. This conversion increases peat oxidation which contribute... | 10.1038/s43017-022-00289-6 | This paper reviews current understanding of intact and degraded peatlands in Southeast Asia and proposes an approach for peatland management and restoration involving explicit consideration of interacting ecological factors and the involvement of local communities |
10.1111/acel.13080 | 29,102,346 | Abstract The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or pr... | 10.1038/s43587-022-00247-3 | This Review article explains the need for measures of biological and physiological aging. |
10.1111/joim.13024 | 60,574,927 | Abstract Over the past three decades, considerable effort has been dedicated to quantifying the pace of ageing yet identifying the most essential metrics of ageing remains challenging due to lack of comprehensive measurements and heterogeneity of the ageing processes. Most of the previously proposed metrics of ageing h... | 10.1038/s43587-022-00247-3 | This paper describes the BLSA and the estimates of the longitudinal trajectories of physiological metrics of aging over the adult lifespan. |
10.1063/1.322014 | 20,100,558 | A ferroelectric field-effect transistor has been investigated using a thin film of bismuth titanate (Bi4Ti3O12) deposited on a Si substrate by rf sputtering. Achievement of the ferroelectric polycrystalline Bi4Ti3O12 films without any cracks necessitates postdeposition heat treatment in air at temperatures ?550 °C for ... | 10.1038/s41928-020-00492-7 | This work demonstrated one of the earliest ferroelectric field-effect transistors and used a perovskite oxide based ferroelectric. |
10.1126/science.aba3993 | 122,995,128 | Quantum control of complex objects in the regime of large size and mass provides opportunities for sensing applications and tests of fundamental physics. The realization of such extreme quantum states of matter remains a major challenge. We demonstrate a quantum interface that combines optical trapping of solids with c... | 10.1038/s42005-021-00656-7 | Cooling to the ground state of a ~150 nm optically levitated silica nanoparticle from room temperature |
10.1038/s41467-022-28536-w | 136,275,446 | Abstract Enzyme catalysts are an integral part of green chemistry strategies towards a more sustainable and resource-efficient chemical synthesis. However, the use of biocatalysed reactions in retrosynthetic planning clashes with the difficulties in predicting the enzymatic activity on unreported substrates and enzyme-... | 10.1038/s41929-022-00909-w | This paper describes the development of a template-free retrobiosynthesis tool by training a molecular transformer with multi-task transfer learning using both enzymatic and chemical reaction databases |
10.1038/s41467-022-30970-9 | 128,072,245 | Abstract The complete biosynthetic pathways are unknown for most natural products (NPs), it is thus valuable to make computer-aided bio-retrosynthesis predictions. Here, a navigable and user-friendly toolkit, BioNavi-NP, is developed to predict the biosynthetic pathways for both NPs and NP-like compounds. First, a sing... | 10.1038/s41929-022-00909-w | This paper introduces a useful retrobiosynthesis tool for navigating biosynthetic pathways to complex natural products from simple building blocks |
10.1101/2021.07.18.452833 | 62,252,472 | Bypassing nature's evolutionary trajectory, de novo protein generation - defined as creating artificial protein sequences from scratch - could enable breakthrough solutions for biomedical and environmental challenges. Viewing amino acid sequences as a language, we demonstrate that a deep learning-based language model c... | 10.1038/s41929-022-00909-w | Using a global language model trained on protein sequences and annotations, the authors demonstrate a universal generative model capable of generating protein sequences with desired properties with a varying degree of sequence similarity |
10.1073/pnas.2001562117 | 81,514,326 | Enzyme turnover numbers ( k cat s) are essential for a quantitative understanding of cells. Because k cat s are traditionally measured in low-throughput assays, they can be inconsistent, labor-intensive to obtain, and can miss in vivo effects. We use a data-driven approach to estimate in vivo k cat s using metabolic sp... | 10.1038/s41929-022-00909-w | This paper reports fluxomic and proteomic data for estimating in vivo k cat values that were used to parameterize a metabolic model that could then be used for more accurate gene expression prediction |
10.1182/blood-2014-01-552174 | 62,211,406 | Key Points The frequency of CD8+CD45RA+CCR7+ cells, a subset closest to T-memory stem cells, correlates with CAR–T-cell expansion in lymphoma patients. IL-7 and IL-15 increase the frequency of CD8+CD45RA+CCR7+ cells during the ex vivo expansion of CAR+ T cells. | 10.1038/s44222-023-00031-x | This article demonstrates that CAR T cells’ in vivo expansion and antitumour efficacy is positively correlated with the number of T SCM cells. |
10.1182/blood.2021011597 | 133,043,225 | Abstract Current limitations in using chimeric antigen receptor T(CART) cells to treat patients with hematological cancers include limited expansion and persistence in vivo that contribute to cancer relapse. Patients with chronic lymphocytic leukemia (CLL) have terminally differentiated T cells with an exhausted phenot... | 10.1038/s44222-023-00031-x | This article demonstrates that inhibiting PI3K signalling enhances CAR T cell therapy by normalizing CD4:CD8 ratios and maximizing the number of early memory T cells |
10.1038/s41467-020-19486-2 | 61,779,497 | Abstract Engineering chimeric antigen receptors (CAR) or T cell receptors (TCR) helps create disease-specific T cells for targeted therapy, but the cost and rigor associated with manufacturing engineered T cells ex vivo can be prohibitive, so programing T cells in vivo may be a viable alternative. Here we report an inj... | 10.1038/s44222-023-00031-x | This article describes and characterizes a polymer nanoparticle bearing a CAR or T cell receptor encoding mRNA to transiently reprogramme T cells in vivo |
10.1126/science.1172484 | 123,084,645 | << Focusing on Fibrin Vascular injury initiates biochemical reactions that cause the blood protein, fibrin, to polymerize and help to stop bleeding and support wound healing. Fibrin can also be a scaffold for thrombi that lead to cardiovascular diseases. To maintain homeostasis, fibrin clots must be stiff, plasti... | 10.1038/s42254-019-0036-4 | An impressive multiscale experimental study of the role of structural hierarchy in increasing the mechanical strength of fibrin |
10.1073/pnas.1222787110 | 103,841,760 | We show that the nonlinear mechanical response of networks formed from un–cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response arises from a shift of a characteristic nonlinear stress–strain relatio... | 10.1038/s42254-019-0036-4 | Confocal imaging directly reveals that fibrin and collagen networks exhibit plasticity owing to a combination of network-level and fibre-level remodelling in response to cyclic shear |
10.1073/pnas.1613058113 | 123,193,782 | In native states, animal cells of many types are supported by a fibrous network that forms the main structural component of the ECM. Mechanical interactions between cells and the 3D ECM critically regulate cell function, including growth and migration. However, the physical mechanism that governs the cell interaction w... | 10.1038/s42254-019-0036-4 | A study highlighting the importance of nonlinear elasticity in cellular mechanosensing |
10.1126/science.1134404 | 101,052,859 | Cells both actively generate and sensitively react to forces through their mechanical framework, the cytoskeleton, which is a nonequilibrium composite material including polymers and motor proteins. We measured the dynamics and mechanical properties of a simple three-component model system consisting of myosin II, acti... | 10.1038/s42254-019-0036-4 | A seminal study unveiling the effects of stresses generated by molecular motor activity on cytoskeletal mechanics |
10.1083/jcb.200601060 | 122,482,843 | Cytoskeletal microtubules have been proposed to influence cell shape and mechanics based on their ability to resist large-scale compressive forces exerted by the surrounding contractile cytoskeleton. Consistent with this, cytoplasmic microtubules are often highly curved and appear buckled because of compressive loads. ... | 10.1038/s42254-019-0036-4 | A combined in vivo and in vitro study showing the importance of the composite architecture of the cytoskeleton for cell mechanics |
10.1126/science.1102896 | 41,774,077 | We describe monocrystalline graphitic films, which are a few atoms thick but are nonetheless stable under ambient conditions, metallic, and of remarkably high quality. The films are found to be a two-dimensional semimetal with a tiny overlap between valence and conductance bands, and they exhibit a strong ambipolar ele... | 10.1038/s43586-022-00139-1 | The first report of the exfoliation of single-layer graphene using adhesive tape |
10.1038/s41467-020-16266-w | 83,043,620 | Abstract Two-dimensional materials provide extraordinary opportunities for exploring phenomena arising in atomically thin crystals. Beginning with the first isolation of graphene, mechanical exfoliation has been a key to provide high-quality two-dimensional materials, but despite improvements it is still limited in yie... | 10.1038/s43586-022-00139-1 | This paper introduces a universal mechanical exfoliation technology for large-area 2D crystals that uses Au films to enhance the interfacial interaction between a 2D material and a substrate |
10.1126/science.aao5360 | 38,407,382 | Coherent strained superlattices Two-dimensional superlattices represent the atomic-thickness limit of heterostructures that enable technologies such as strain-engineered multiferroics and quantum-cascade lasers. Xie et al. were able to produce monolayer superlattices of transition metal dichalcogenides (WS 2 and WSe 2 ... | 10.1038/s43586-022-00139-1 | This paper describes the modulated metal–organic CVD approach for producing 2D lateral superlattices |
10.1126/science.aan6814 | 83,421,018 | Cycling 2D crystal growth The electronic and optical properties of two-dimensional (2D) transitional metal dichalcogenides such as MoS 2 and WSe 2 could be modulated by creating in-plane superlattices and heterostructures from these materials. However, single layers of these materials are fragile and often do not withs... | 10.1038/s43586-022-00139-1 | This paper introduces the multistep CVD approach for lateral 2D heterostructures with reverse flow capability for better control of sample quality |
10.1002/adma.201902166 | 123,844,411 | Abstract Engineered heterostructures create new functionality by integrating dissimilar materials. Combining different 2D crystals naturally produces two distinct classes of heterostructures, vertical van der Waals (vdW) stacks or 2D sheets bonded laterally by covalent line interfaces. When joining thicker layered crys... | 10.1038/s43586-022-00139-1 | This paper introduces a new type of van der Waals heterostructure with promising light harvesting properties, opening up van der Waals architectures beyond the archetypal vertical stacks and laterally stitched 2D layers |
10.1002/adma.202006649 | 59,659,665 | Abstract Ultrathin van der Waals semiconductors have shown extraordinary optoelectronic and photonic properties. Propagating photonic modes make layered crystal waveguides attractive for photonic circuitry and for studying hybrid light–matter states. Accessing guided modes by conventional optics is challenging due to t... | 10.1038/s43586-022-00139-1 | This paper discusses synthetic ultrathin 3D-shaped van der Waals nanoribbon waveguides and explains the coherent electron-beam excitation of photonic modes in such waveguides |
10.1126/science.abc4284 | 19,010,191 | Euclidean geometry is the fundamental mathematical framework of classical crystallography. Traditionally, layered materials are grown on flat substrates; growing Euclidean crystals on non-Euclidean surfaces has rarely been studied. We present a general model describing the growth of layered materials with screw-disloca... | 10.1038/s43586-022-00139-1 | This work demonstrates control over interlayer twist in dislocated growth spirals of TMDs synthesized on non-planar substrates |
10.1073/pnas.0914117107 | 41,117,422 | Deposition of high- κ dielectrics onto graphene is of significant challenge due to the difficulties of nucleating high quality oxide on pristine graphene without introducing defects into the monolayer of carbon lattice. Previous efforts to deposit high- κ dielectrics on graphene often resulted in significant degradatio... | 10.1038/s43586-022-00139-1 | This study first demonstrates damage-free 2D semiconductor–dielectric van der Waals integration with pristine interfaces and retained electronic performance |
10.1126/science.1188302 | 83,477,929 | Just Breathe Design of artificial systems that mimic in vivo organs could provide a better alternative for understanding mechanisms underlying physiological responses than current cell-based models or animal tests. Huh et al. (p. 1662 ) have created a tissue-tissue interface of human-cultured epithelial cells and endot... | 10.1038/s43586-022-00118-6 | This paper is one of the pioneering works on lung OoC, which demonstrates a functional alveolar–capillary interface that is responsive to pathogen infection |
10.1039/c6lc01554a | 83,351,772 | We reviewed the foundational technologies underlying the commercialization efforts of the current prominent organ-on-a-chip start-ups. | 10.1038/s43586-022-00118-6 | This review discusses the commercialization trajectory of OoC technologies into the drug discovery market |
10.1039/c8lc00336j | 80,300,944 | A versatile injection-molded platform with fast, robust, and simple liquid patterning capable of 3D co-culture experiments. | 10.1038/s43586-022-00118-6 | This paper presents the basis for high-throughput microfluidic organ-on-a-chip design that is amenable for 3D co-cultures. Furthermore, the device designs described here are compatible with 3D printing and injection moulding such that they offer an alternative to traditional PDMS-based chips |
10.1038/s41378-020-0164-0 | 58,880,554 | Abstract The intricate microarchitecture of tissues – the “tissue microenvironment” – is a strong determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate, manipulate, and analyze the tissue microenvironment in live tissues and engineer mass transport around and into small tissue v... | 10.1038/s43586-022-00118-6 | This article is a reference for readers interested in the integration of live intact tissue slices into a microfluidic system |
10.1039/c9lc00160c | 123,089,676 | Modular multi-organ perfusion systems offer the unique opportunity to customize different physiological systemic interactions. | 10.1038/s43586-022-00118-6 | This paper demonstrates a modular design of assembling pre-established tissue chips into a recirculating multi-OoC system |
10.1177/2472630318802582 | 32,110,197 | Microphysiological systems hold the promise to increase the predictive and translational power of in vitro substance testing owing to their faithful recapitulation of human physiology. However, the implementation of academic developments in industrial settings remains challenging. We present an injection-molded microfl... | 10.1038/s43586-022-00118-6 | This paper describes a scalable and automation-compatible multi-spheroid culture system in a microtitre plate format based on gravity-driven flow that is actuated by tilting |
10.1038/srep44517 | 109,424,627 | Scientific Reports 7: Article number: 42296; published online: 08 February 2017; updated: 16 March 2017 The original version of this Article contained an error in Affiliation 2, which was incorrectly given as: ‘Department of Computational and Systems Biology, University of Pittsburgh, Baltimore, PA,USA’. | 10.1038/s43586-022-00118-6 | This paper combines multiple single-OoCs by manual transfer of culture medium from one organ to the next to simulate multi-organ functions; termed functional coupling rather than direct coupling of organs in a flow-through system |
10.1126/scitranslmed.aav1386 | 41,542,615 | A pumpless, reconfigurable, multi-organ–on–a–chip system containing recirculating serum-free medium can be used to predict preclinical on-target efficacy, metabolic conversion, and measurement of off-target toxicity of drugs using functional biological microelectromechanical systems. In the first configuration of the s... | 10.1038/s43586-022-00118-6 | Together with Viravaidya et al. (2004) and Edington et al. (2018), this paper and the above-mentioned papers have been selected as case studies to highlight evolution in the design of multi-OoC systems for ADME-Tox studies |
10.3390/bios10090110 | 38,235,931 | Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular environments, they represent promising tools for tissue engineering and... | 10.1038/s43586-022-00118-6 | This review covers the integration of sensors into OoC devices for real-time measurements of oxygen, soluble metabolites (for example, glucose or lactate cytokines), TEER and electrical activity |
10.1063/1.5097675 | 67,383,528 | Recent advances in organ-on-a-chip technology have resulted in numerous examples of microscale systems that faithfully mimic the physiology and pathology of human organs and diseases. The next step in this field, which has already been partially demonstrated at a proof-of-concept level, would be integration of organ mo... | 10.1038/s43586-022-00118-6 | This paper provides a useful guide to design principles and scaling rules for multi-OoC systems to be used for PK and PD studies |
10.1146/annurev-anchem-062011-143122 | 20,176,261 | Although stem cell fate is traditionally manipulated by exogenously altering the cells' extracellular signaling environment, the endogenous autocrine and paracrine signals produced by the cells also contribute to their two essential processes: self-renewal and differentiation. Autocrine and/or paracrine signals are fun... | 10.1038/s43586-022-00118-6 | This review paper explains the physics governing the use of microfluidic cell culture to control the presentation of soluble factors to cells in order to investigate paracrine and autocrine signalling |
10.1063/5.0012185 | 14,797,458 | Dysregulation of the human microbiome has been linked to various disease states, which has galvanized the efforts to modulate human health through microbiomes. Currently, human microbiome research is going through several phases to identify the constituent components of the microbiome, associate microbiome changes with... | 10.1038/s43586-022-00118-6 | This review highlights OoC systems that specifically model microbial–mammalian host tissue interactions |
10.1038/s41392-020-0134-x | 62,324,943 | Abstract Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of th... | 10.1038/s43018-023-00514-1 | A review article that describes recent advancements in the study of the biological mechanisms of the metastatic process. |
10.1177/1758834016644156 | 81,887,510 | Invasive lobular carcinoma (ILC) is the second most common histologic subtype of breast cancer (BC): ILC differs from invasive ductal carcinoma (IDC) in its clinicopathological characteristics and responsiveness to systemic therapy. From the clinical standpoint, data suggest that ILC derives a distinct benefit from sys... | 10.1038/s43018-023-00528-9 | A review article that presents a summary of clinical practices for IDC and ILC, highlighting the need for subtype-specific therapeutic approaches. |
10.1038/s41523-019-0133-7 | 107,161,793 | Abstract Historically, breast cancer tumors have been considered immunologically quiescent, with the majority of tumors demonstrating low lymphocyte infiltration, low mutational burden, and modest objective response rates to anti-PD-1/PD-L1 monotherapy. Tumor and immunologic profiling has shed light on potential mechan... | 10.1038/s43018-023-00528-9 | A comprehensive review that gives a rationale for immunotherapeutic approaches for breast cancer and details potential future strategies. |
10.1126/scitranslmed.aad5904 | 38,209,479 | Anatomically shaped living bone formed in a portable bioreactor using autologous cells and bone matrix repaired the facial ramus-condyle unit in pigs. | 10.1038/s44222-023-00036-6 | This article reports single-use perfusion bioreactors for engineering autologous, custom-designed, craniofacial bone grafts with complex geometries in large animals as a proof of principle for first-in-human use. |
10.1126/science.284.5413.489 | 38,221,689 | A tissue engineering approach was developed to produce arbitrary lengths of vascular graft material from smooth muscle and endothelial cells that were derived from a biopsy of vascular tissue. Bovine vessels cultured under pulsatile conditions had rupture strengths greater than 2000 millimeters of mercury, suture reten... | 10.1038/s44222-023-00036-6 | This article reports a pulsatile bioreactor-based tissue-engineering approach to developing autologous arteries, which formed the foundation of FDA-designated human acellular vessels by Humacyte. |
10.1038/s41467-022-32066-w | 142,387,520 | Abstract While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynt... | 10.1038/s44222-022-00004-6 | This article reports photosynthetic microcapsules based on algal microorganisms and upconverted nanoparticles that can be applied to create a hyperoxic TME and improve outcomes of PD-1 antibody therapy |
10.1126/scitranslmed.aan3682 | 62,244,644 | A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity. | 10.1038/s44222-022-00004-6 | This article reports ROS-scavenging hydrogels that can be applied to reduce the level of ROS in tumours, thereby improving chemotherapy combined with PD-L1 antibody therapy |
10.1002/adma.201900192 | 41,681,956 | Abstract Chimeric antigen receptor (CAR)‐redirected T lymphocytes (CAR T cells) show modest therapeutic efficacy in solid tumors. The desmoplastic structure of the tumor and the immunosuppressive tumor microenvironment usually account for the reduced efficacy of CAR T cells in solid tumors. Mild hyperthermia of the tum... | 10.1038/s44222-022-00004-6 | This article reports that mild photothermal effects dilate tumour blood vessels and accelerate intratumoral blood flow, thereby improving CAR T cell infiltration and thus, CAR T cell therapy |
10.1088/1674-4926/41/6/061101 | 75,924,648 | Abstract To have a high quality experimental growth of crystals, understanding the equilibrium crystal shape (ECS) in different thermodynamic growth conditions is important. The factor governing the ECS is usually the absolute surface formation energies for surfaces (or edges in 2D) in different orientations. Therefore... | 10.1038/s43588-022-00356-4 | A review article that stresses the necessity of surface energies. |
10.1126/science.aac8343 | 20,833,320 | Improving cobalt catalysts Tethering molecular catalysts together is a tried and trusted method for making them easier to purify and reuse. Lin et al. now show that the assembly of a covalent organic framework (COF) structure can also improve fundamental catalytic performance. They used cobalt porphyrin complexes as bu... | 10.1038/s41929-018-0051-3 | The first report incorporating metal complexes into porous frameworks to achieve high activity for CO 2 -to-CO conversion in water |
10.1126/science.aaf4767 | 20,829,322 | Small and salty CO 2 reduction scheme Most artificial photosynthesis approaches focus on making hydrogen. Modifying CO 2 , as plants and microbes do, is more chemically complex. Asadi et al. report that fashioning WSe 2 and related electrochemical catalysts into nanometer-scale flakes greatly improves their activity fo... | 10.1038/s41929-018-0051-3 | Nanostructured transition metal dichalcogenides represent the most efficient electrocatalysts for heterogeneous CO 2 -to-CO conversion in aqueous media |
10.1038/s41467-017-00559-8 | 2,697,584 | Abstract Significant efforts have been devoted over the last few years to develop efficient molecular electrocatalysts for the electrochemical reduction of carbon dioxide to carbon monoxide, the latter being an industrially important feedstock for the synthesis of bulk and fine chemicals. Whereas these efforts primaril... | 10.1038/s41929-018-0051-3 | The first example of applying electrochemistry for a scalable reduction of CO 2 to CO coupled to ensuing carbonylative transformations |
10.1111/risa.12663 | 4,599,980 | Evidence‐based information on household‐level adaptation is an important element of integrated management of vulnerable coastal regions. A growing number of empirical studies deal with household‐level adaptation at the coast in different regions. This article provides a systematic review of these studies. We analyze st... | 10.1038/s43017-019-0002-9 | A review of household coastal adaptation processes, including the sociodemographic characteristics of who adapts in place |
10.1126/sciadv.1400180 | 83,433,195 | The growth in technological innovation that has occurred over the past decades has, in part, been possible because an increasing number of metals of the periodic table are used to perform specialized functions. However, there have been increasing concerns regarding the reliability of supply of some of these metals. A m... | 10.1038/s44221-022-00006-z | This study demonstrates that many companion metals are essential to modern technology but are particularly susceptible to supply constraints in the coming decades |
10.1002/adma.202101312 | 132,880,131 | Abstract Synthetic polymer membranes are enabling components in key technologies at the water–energy nexus, including desalination and energy conversion, because of their high water/salt selectivity or ionic conductivity. However, many applications at the water–energy nexus require ion selectivity, or separation of spe... | 10.1038/s44221-022-00006-z | This paper describes membrane materials that may lead to high-precision ion separations |
10.1002/anie.201607329 | 104,191,822 | Abstract Extraction of lithium ions from salt‐lake brines is very important to produce lithium compounds. Herein, we report a new approach to construct polystyrene sulfonate (PSS) threaded HKUST‐1 metal–organic framework (MOF) membranes through an in situ confinement conversion process. The resulting membrane PSS@HKUST... | 10.1038/s44221-022-00006-z | Metal–organic frameworks were used to develop membranes with a selectivity of 1,815 for lithium over magnesium |
10.1063/1.1416902 | 60,892,821 | This review contains selected values of thermodynamic quantities for the aqueous ionization reactions of 64 buffers, many of which are used in biological research. Since the aim is to be able to predict values of the ionization constant at temperatures not too far from ambient, the thermodynamic quantities which are ta... | 10.1038/s43586-023-00199-x | This paper contains thermodynamic parameters for the aqueous ionization of the most common biological buffers, being of paramount importance for ITC experimental design and data analysis |
10.1126/science.1106435 | 41,719,054 | The rate of ammonia synthesis over a nanoparticle ruthenium catalyst can be calculated directly on the basis of a quantum chemical treatment of the problem using density functional theory. We compared the results to measured rates over a ruthenium catalyst supported on magnesium aluminum spinel. When the size distribut... | 10.1038/s41929-022-00839-7 | The authors perform DFT calculations to predict the reaction rates of N 2 reduction on Ru particle catalysts, in which Ru particles larger than 2 nm are able to provide step sites for N 2 dissociation |
10.1126/science.1192449 | 20,809,588 | Substituting Salt for Cerium Oxide The water-gas shift reaction converts carbon monoxide and water to hydrogen and carbon dioxide. Catalysts that operate at lower temperatures will be useful in fuel cells. Nanoparticles of platinum adsorbed on reducible oxides, such as ceria, can stabilize catalytically active Ptoxygen... | 10.1038/s41929-022-00839-7 | Na + additive in Pt/SiO 2 catalyst assists the dissociation of water and provides a large amount of OH group, which helps to activate CO on Pt centres and leads to a much higher water-gas shift reaction activity at low temperatures as compared with that of the Pt/SiO 2 catalyst with no alkali metal additives |
10.1002/wcms.1238 | 4,729,298 | Ongoing developments of hardware and software are changing computational spectroscopy from a strongly specialized research area to a general tool in the inventory of most researchers. Increased interactions between experimentally oriented users and theoretically oriented developers of new methods and models would resul... | 10.1038/s43586-021-00034-1 | This review introduces a new and more intuitive approach of computational spectroscopy based on the vis-à-vis comparison of calculated and experimental spectra instead of the mere computation of spectroscopic parameters |
10.1002/qua.25188 | 107,324,721 | Abstract In this tutorial review, we present some effective methodologies available for the simulation of vibrational and vibrationally resolved electronic spectra of medium‐to‐large molecules. They have been integrated into a unified platform and extended to support a wide range of spectroscopies. The resulting tool i... | 10.1038/s43586-021-00034-1 | This tutorial review presents a detailed computational protocol and guidelines for the simulation of vibrational and vibrationally resolved electronic spectra for medium to large molecular systems of increasing flexibility |
10.1146/annurev-physchem-052516-044827 | 122,031,854 | Computations of natural optical activity (OA) from first principles (ab initio) have become indispensable in chiroptical studies of molecular systems. Calculations are used to assign absolute configurations and to analyze chiroptical data, providing a basis for understanding their origin as well as for assigning and pr... | 10.1038/s43586-021-00034-1 | This recent review outlines computational models and methodological developments for chiroptical spectroscopic methods that include optical rotation, ECD, VCD and ROA |
10.1063/1.431514 | 59,311,828 | A simple random-walk method for obtaining ab initio solutions of the Schrödinger equation is examined in its application to the case of the molecular ion H+3 in the equilateral triangle configuration with side length R=1.66 bohr. The method, which is based on the similarity of the Schrödinger equation and the diffusion... | 10.1038/s43586-021-00034-1 | This key publication introduces the DMC approaches described in this Primer to the chemistry community |
10.1063/1.3086717 | 20,842,875 | Coupled-electron pair approximations (CEPAs) and coupled-pair functionals (CPFs) have been popular in the 1970s and 1980s and have yielded excellent results for small molecules. Recently, interest in CEPA and CPF methods has been renewed. It has been shown that these methods lead to competitive thermochemical, kinetic,... | 10.1038/s43586-021-00034-1 | This key publication reports the development and validation of an approach to extend the application of accurate quantum-chemical methods to large molecular systems |
10.1063/1.2148954 | 125,119,493 | A new hybrid density functional for general chemistry applications is proposed. It is based on a mixing of standard generalized gradient approximations (GGAs) for exchange by Becke (B) and for correlation by Lee, Yang, and Parr (LYP) with Hartree-Fock (HF) exchange and a perturbative second-order correlation part (PT2)... | 10.1038/s43586-021-00034-1 | This key publication reports the introduction of double-hybrid functionals allowing quantitative spectroscopic studies by DFT |
10.1063/1.5129672 | 125,189,060 | In the past two decades, the density matrix renormalization group (DMRG) has emerged as an innovative new method in quantum chemistry relying on a theoretical framework very different from that of traditional electronic structure approaches. The development of the quantum chemical DMRG has been remarkably fast: it has ... | 10.1038/s43586-021-00034-1 | This review is the most recent on the use of methods rooted in the density matrix renormalization group for vibrational and electronic spectroscopy |
10.1073/pnas.191266498 | 45,575,105 | Extensive terahertz laser vibration-rotation-tunneling spectra and mid-IR laser spectra have been compiled for several isotopomers of small (dimer through hexamer) water clusters. These data, in conjunction with new theoretical advances, quantify the structures, force fields, dipole moments, and hydrogen bond rearrange... | 10.1038/s43586-021-00034-1 | This comprehensive review discusses how theory is used to predict and interpret experimental measurements of spectra for water clusters |
10.1113/jphysiol.2010.201855 | 19,033,086 | The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an important Ca 2+ signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death. Its ability to respond to reactive oxygen species has made TRPM2... | 10.1038/s44161-022-00037-5 | A Review that presents the many roles of TRPM2-mediated calcium signaling in cellular functions |
10.4049/jimmunol.0901293 | 18,123,302 | Abstract Outside of the TLR paradigm, there is little understanding of how pathogen recognition at the cell surface is linked to functional responses in cells of the innate immune system. Recent work in this area demonstrates that the yeast particle zymosan, by binding to the β-glucan receptor Dectin-1, activates an IT... | 10.1038/s44161-022-00037-5 | This paper reports the critical role of calcium signaling in activating macrophages |
10.1111/j.1467-2979.2011.00404.x | 107,092,128 | Abstract The study of environmental impacts of seafood production as a result of ecolabelling and certification is a young yet rapidly growing discipline that lacks theoretical models. Pieces of the model have been suggested in the literature, and these pieces are formalized here realizing the current operating paramet... | 10.1038/s41893-018-0115-z | Paper arguing the need to move beyond single threshold modes of assessing sustainability, such as certification, to multiple threshold mechanisms that reward innovation and incremental improvement |
10.1111/jems.12061 | 4,825,973 | We study markets in which consumers prefer green products but cannot determine the environmental quality of any given firm's product on their own. A nongovernmental organization (NGO) can establish a voluntary standard and label products that comply with it. Alternatively, industry can create its own standard and label... | 10.1038/s41893-018-0115-z | Theoretical article analysing the impact of ecolabel competition in the market where ecolabels have different standards |
10.1126/science.aaa4639 | 59,096,185 | Require improvements as conditions for market access | 10.1038/s41893-018-0115-z | Analysis highlighting the limitations of FIPs to incentivize developing world fisheries to improve their sustainability performance in (partial) response to weak conditionality for access to international retail markets |
10.1038/s41467-020-15488-2 | 15,133,197 | Abstract Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increase... | 10.1038/s42255-023-00764-4 | This paper reports promotion of BAT development and energy expenditure by METTL3 in mice |
10.1073/pnas.0500563102 | 62,352,362 | Mutations in mtDNA are responsible for a variety of mitochondrial diseases, where the mitochondrial tRNA Leu(UUR) gene has especially hot spots for pathogenic mutations. Clinical features often depend on the tRNA species and/or positions of the mutations; however, molecular pathogenesis elucidating the relation between... | 10.1038/s42255-023-00764-4 | This paper reports impaired mitochondrial tRNA taurine modification by MELAS-associated mutations |
10.1126/science.aad6780 | 125,241,810 | Offspring affected by sperm small RNAs Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse spe... | 10.1038/s42255-023-00764-4 | The studies by Chen et al. (ref. 115) and Sharma et al. (ref. 116) report contribution of sperm tsRNAs to transmission of the paternal environment to offspring phenotypes |
10.2134/agronj2005.0180 | 103,649,651 | Rice ( Oryza sativa L.) breeders have historically not included nitrogen utilization efficiency (NUE) as a selection criterion in breeding for cultivars, even though it has economic and ecological implications. This study examined the significance and magnitude of variation in N content, NUE, N translocation ratio (NTR... | 10.1038/s41598-022-17109-y | (Texas A&M Univ. Sys. AgriLife Res. & Ext. Ctr., Beaumont) |
10.1126/sciadv.1600304 | 82,423,524 | Electron transport coupled with magnetism has attracted attention over the years. Among them, recently discovered is topological Hall effect (THE), originating from scalar spin chirality, that is, the solid angle subtended by the spins. THE is found to be a promising tool for probing the Dzyaloshinskii-Moriya (DM) inte... | 10.1038/s43246-022-00238-2 | The first observation of a topological Hall effect in SrRuO 3 |
10.1038/s41467-021-22976-6 | 135,679,863 | Abstract The topological Hall effect is used extensively to study chiral spin textures in various materials. However, the factors controlling its magnitude in technologically-relevant thin films remain uncertain. Using variable-temperature magnetotransport and real-space magnetic imaging in a series of Ir/Fe/Co/Pt hete... | 10.1038/s43246-022-00238-2 | A possible explanation for the commonly observed disagreement between the predicted skyrmion density from topological Hall effect measurements and real-space micro-magnetic imaging |
10.1126/science.1202432 | 29,279,016 | Putting the F in Friedel-Crafts The Friedel-Crafts class of reactions, among the oldest and most broadly applied in organic chemistry, form carbon-carbon bonds between aromatic rings and a variety of non-aromatic substituents, such as alkyl groups. Generally, a metal complex is used to activate chlorinated or brominate... | 10.1038/s42004-019-0160-1 | Application of fluorinated precursors in aromatic area extension of corannulene |
10.1002/anie.201502599 | 102,089,694 | Abstract A novel nitrogen‐doped corannulene derivative, 8‐tert‐butyl‐6b 2 ‐azapentabenzo[bc,ef,hi,kl,no]corannulene, was synthesized by 1,3‐dipolar cycloaddition of a polycyclic aromatic azomethine ylide with a diarylethyne and subsequent palladium‐catalyzed intramolecular cyclization. This molecule represents the firs... | 10.1038/s42004-019-0160-1 | First report on incorporation of nitrogen atom into the central five-membered ring of a corannulene derivative |
10.1073/pnas.1805397115 | 82,861,704 | The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα−interacting protein. By shielding cytoplasmic OGT from proteasomal... | 10.1038/s44161-022-00173-y | This article from our team shows the protein–protein interactions of REV-ERBα |
10.1261/rna.1136108 | 82,698,503 | RNA levels in a cell are determined by the relative rates of RNA synthesis and decay. State-of-the-art transcriptional analyses only employ total cellular RNA. Therefore, changes in RNA levels cannot be attributed to RNA synthesis or decay, and temporal resolution is poor. Recently, it was reported that newly transcrib... | 10.1038/s43586-022-00157-z | Dölken et al. exemplify the benefits of metabolic labelling for measuring short-term changes in RNA synthesis and decay in the interferon response of fibroblasts. |
10.1002/anie.201707465 | 82,719,099 | Abstract To understand the functional roles of RNA in the cell, it is essential to elucidate the dynamics of their production, processing and decay. A recent method for assessing mRNA dynamics is metabolic labeling with 4‐thiouridine (4sU), followed by thio‐selective attachment of affinity tags. Detection of labeled tr... | 10.1038/s43586-022-00157-z | This article provides the conceptual basis for nucleotide conversion sequencing using Osmium-mediated 4sU-to-C conversion. |
10.1093/bioinformatics/bty256 | 26,917,086 | Abstract Summary: Global quantification of total RNA is used to investigate steady state levels of gene expression. However, being able to differentiate pre-existing RNA (that has been synthesized prior to a defined point in time) and newly transcribed RNA can provide invaluable information e.g. to estimate RNA half-li... | 10.1038/s43586-022-00157-z | GRAND-SLAM provides a computational framework that enables the proportion of old and new RNA to be estimated. |
10.1038/s41467-021-23834-1 | 128,850,594 | Abstract Early stages of embryogenesis depend on subcellular localization and transport of maternal mRNA. However, systematic analysis of these processes is hindered by a lack of spatio-temporal information in single-cell RNA sequencing. Here, we combine spatially-resolved transcriptomics and single-cell RNA labeling t... | 10.1038/s43586-022-00157-z | Holler et al. combine metabolic RNA labelling with spatially resolved transcriptomics to measure activation of cygotic transcription in the zebrafish embryo. |
10.1038/s41467-019-11028-9 | 20,636,455 | Abstract Sequencing of newly synthesised RNA can monitor transcriptional dynamics with great sensitivity and high temporal resolution, but is currently restricted to populations of cells. Here, we develop new transcriptome alkylation-dependent single-cell RNA sequencing (NASC-seq), to monitor newly synthesised and pre-... | 10.1038/s43586-022-00157-z | This article introduces NASC-seq to perform 4sU RNA metabolic labelling at the single-cell level in plate-based format. |
10.1126/science.aax3072 | 104,344,286 | The regulation of messenger RNA levels in mammalian cells can be achieved by the modulation of synthesis and degradation rates. Metabolic RNA-labeling experiments in bulk have quantified these rates using relatively homogeneous cell populations. However, to determine these rates during complex dynamical processes, for ... | 10.1038/s43586-022-00157-z | Battich et al. employ ethynyluridine labelling in single cells to estimate RNA synthesis and decay rates in thousands of intestinal organoid cells. |
10.1038/s41467-022-28686-x | 136,219,499 | Abstract Artificial photosynthesis of H 2 O 2 using earth-abundant water and oxygen is a promising approach to achieve scalable and cost-effective solar fuel production. Recent studies on this topic have made significant progress, yet are mainly focused on using organic polymers. This set of photocatalysts is susceptib... | 10.1038/s44160-023-00273-y | This article presents the photosynthesis of H 2 O 2 using a Mo-doped faceted BiVO 4 photocatalyst. |
10.1038/s41467-021-22394-8 | 4,860,063 | Abstract Photocatalytic hydrogen peroxide (H 2 O 2 ) generation represents a promising approach for artificial photosynthesis. However, the sluggish half-reaction of water oxidation significantly limits the efficiency of H 2 O 2 generation. Here, a benzylamine oxidation with more favorable thermodynamics is employed as... | 10.1038/s44160-023-00273-y | This paper reports the photosynthesis of H 2 O 2 coupled with benzylamine oxidation. |
10.1155/2021/6618837 | 76,517,588 | Mitochondrial Pyruvate Carrier 1 (MPC1), one of the rate-limiting proteins involved in glycolysis metabolism, has been demonstrated as a tumor inhibitor in several cancers. This study was conducted with the aim of exploring the role and underlying mechanisms of MPC2 in colorectal cancer (CRC). Here, we found that MPC2 ... | 10.1038/s41598-022-06186-8 | contributes to aerobic glycolysis and colorectal cancer proliferation by activati 2021 |
10.1002/chin.201634012 | 25,441,444 | Abstract Stable atomically dispersed Pd catalyst particles on ethylene glycolate (EG)‐stabilized ultrathin TiO 2 nanosheet supports (Pd ≤1.5%) are prepared by UV irradiation (Xe lamp) of an aqueous suspension of two‐atom‐thick TiO 2 nanosheets and H 2 PdCl 4 . | 10.1038/s41929-018-0090-9 | The atomically dispersed Pd catalyst on ultrathin TiO 2 nanosheets was prepared under ultraviolet light and exhibited high catalytic activities and stabilities in hydrogenation of C=C and C=O |
10.1039/c6sc02105k | 62,205,623 | The single-atom Co–N–C catalyst with the structure of CoN 4 C 8 -1-2O 2 shows excellent performance for the chemoselective hydrogenation of nitroarenes to produce azo compounds under mild reaction conditions. | 10.1038/s41929-018-0090-9 | The isolated Co site catalyst was successful synthesized by pyrolysis of Co-phen complex and the resulting material displayed good reactivity on preparation of azo products by the hydrogrenation of nitrobenzenes |
10.1073/pnas.1909223116 | 101,173,217 | Self-assembly is widely used by biological systems to build functional nanostructures, such as the protein capsids of RNA viruses. But because assembly is a collective phenomenon involving many weakly interacting subunits and a broad range of timescales, measurements of the assembly pathways have been elusive. We use i... | 10.1038/s42254-020-00267-1 | Pioneering experimental article on following single-particle virus assembly by light-scattering techniques |
10.1073/pnas.0308198101 | 81,700,261 | The shell of bacteriophages protects the viral DNA during host-to-host transfer and serves as a high-pressure container storing energy for DNA injection into a host bacterium. Here, we probe the mechanical properties of nanometer-sized bacteriophage φ29 shells by applying point forces. We show that empty shells withsta... | 10.1038/s42254-020-00267-1 | This paper represents a milestone in physical virology studies, introducing AFM as a tool to study viral mechanics |
10.1038/nature24277 | 41,678,238 | Abstract Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across... | 10.1038/s42255-019-0132-x | The GTEx project’s characterization of variations in gene expression levels across individuals and 44 tissues of the human body |
10.1126/science.aad0189 | 29,223,227 | Expanded proteomic analysis of metabolism Combined analysis of large data sets characterizing genes, transcripts, and proteins can elucidate biological functions and disease processes. Williams et al. report an exceptionally detailed characterization of mitochondrial function in a genetic reference panel of recombinant... | 10.1038/s42255-019-0132-x | Detailed phenotypic, molecular and genetic analyses of BXD animals fed normal or high-fat diets, uncovering new regulatory pathways of hepatic mitochondrial function and clinical outcomes |
10.1101/gr.194118.115 | 62,155,320 | Genetics provides a potentially powerful approach to dissect host-gut microbiota interactions. Toward this end, we profiled gut microbiota using 16s rRNA gene sequencing in a panel of 110 diverse inbred strains of mice. This panel has previously been studied for a wide range of metabolic traits and can be used for high... | 10.1038/s42255-019-0132-x | Analysis of the genetics of gut microbiota composition in HMDP mice, demonstrating high heritability and GxE interactions |
10.1111/j.1365-2486.2009.02110.x | 39,997,169 | Abstract Climate change is expected to cause extensive vegetation changes in the Arctic: deciduous shrubs are already expanding, in response to climate warming. The results from transect studies suggest that increasing shrub cover will impact significantly on the surface energy balance. However, little is known about t... | 10.1038/s43017-021-00233-0 | A field study in which dwarf-shrub canopies were removed experimentally, resulting in increased thaw depths, thereby, underscoring the protective role of vegetation cover on permafrost |
10.5194/bg-15-5287-2018 | 17,638,903 | Abstract. Soils in Arctic and boreal ecosystems store twice as much carbon as the atmosphere, a portion of which may be released as high-latitude soils warm. Some of the uncertainty in the timing and magnitude of the permafrost–climate feedback stems from complex interactions between ecosystem properties and soil therm... | 10.1038/s43017-021-00233-0 | Review article showing how Arctic ecosystem processes can influence soil thermal dynamics in permafrost soil |
10.5194/bg-17-4261-2020 | 80,597,339 | Abstract. Connections between vegetation and soil thermal dynamics are critical for estimating the vulnerability of permafrost to thaw with continued climate warming and vegetation changes. The interplay of complex biophysical processes results in a highly heterogeneous soil temperature distribution on small spatial sc... | 10.1038/s43017-021-00233-0 | A field study reporting that large variations in soil temperatures and thaw depths can be explained by vegetation-mediated differences in snow height |
10.1002/2015jf003602 | 61,401,865 | Abstract Ground ice is abundant in the upper permafrost throughout the Arctic and fundamentally affects terrain responses to climate warming. Ice wedges, which form near the surface and are the dominant type of massive ice in the Arctic, are particularly vulnerable to warming. Yet processes controlling ice wedge degrad... | 10.1038/s43017-021-00233-0 | Outlines the role of ground ice and vegetation succession in thermokarst terrain, including first estimates of recovery times |
10.32942/osf.io/mzyjk | 54,337,493 | As the Arctic warms, vegetation is responding and satellite measures indicate widespread greening at high latitudes. This ‘greening of the Arctic’ is among the world’s most significant large-scale ecological responses to global climate change. However, a consensus is emerging that the underlying causes and future dynam... | 10.1038/s43017-021-00233-0 | Review article outlining complexity in Arctic greening and browning dynamics. The temporal and spatial scale of spectral data and the role of non-vegetation-related processes and ground-truthing remains essential |
10.1007/s10021-020-00589-2 | 80,596,459 | Abstract In the tundra, woody plants are dispersing towards higher latitudes and altitudes due to increasingly favourable climatic conditions. The coverage and height of woody plants are increasing, which may influence the soils of the tundra ecosystem. Here, we use structural equation modelling to analyse 171 study pl... | 10.1038/s43017-021-00233-0 | Quantifies the effects of shrub abundance on the soil thermal regime using a distinction between a rough, tall-shrub canopy and an aerodynamic, dwarf-shrub canopy |
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