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10.1073/pnas.1710465114 | 20,862,194 | Better stewardship of land is needed to achieve the Paris Climate Agreement goal of holding warming to below 2 °C; however, confusion persists about the specific set of land stewardship options available and their mitigation potential. To address this, we identify and quantify “natural climate solutions” (NCS): 20 cons... | 10.1038/s41893-019-0417-9 | A study identifying and quantifying nature-based solutions to climate change |
10.1126/science.1132294 | 104,406,111 | Human-dominated marine ecosystems are experiencing accelerating loss of populations and species, with largely unknown consequences. We analyzed local experiments, long-term regional time series, and global fisheries data to test how biodiversity loss affects marine ecosystem services across temporal and spatial scales.... | 10.1038/s41893-019-0417-9 | A global analysis revealing the importance of biodiversity for the productivity and stability of marine ecosystems |
10.1126/science.aac4971 | 83,244,249 | Warming making bigger CO 2 swings The combined effects of climate change and vegetation dynamics at high northern latitudes have amplified the seasonal variation of atmospheric CO 2 concentrations over the past half century. Forkel et al. combined observations and models to show that climate warming has caused the phot... | 10.1038/s43017-019-0001-x | Presents the linkage between increasing photosynthesis of northern vegetation and the enlarging seasonal CO 2 amplitude |
10.1126/science.aac8083 | 123,198,618 | It's not only the carbon in the trees Forest loss affects climate not just because of the impacts it has on the carbon cycle, but also because of how it affects the fluxes of energy and water between the land and the atmosphere. Evaluating global impact is complicated because deforestation can produce different results... | 10.1038/s43017-019-0001-x | Presents evidence for feedbacks of forest cover change to land-surface temperature and its regional disparities |
10.1029/2010wr009127 | 124,790,434 | There has been a long debate on the extent to which precipitation relies on terrestrial evaporation (moisture recycling). In the past, most research focused on moisture recycling within a certain region only. This study makes use of new definitions of moisture recycling to study the complete process of continental mois... | 10.1038/s43017-019-0001-x | Discusses the importance of land evapotranspiration to sustain downwind precipitation |
10.1039/c7sc04429a | 38,423,898 | A robust precious metal-free photocatalyst system comprised of ligand-free ZnSe quantum dots and a phosphonic acid-functionalised Ni(cyclam) catalyst achieves efficient reduction of aqueous CO 2 to CO. | 10.1038/s41929-020-00512-x | Study using capping ligand design to tune the product selectivity (H 2 versus CO) through blocking of catalytic sites in QD-promoted photoreduction of CO 2 |
10.1073/pnas.1900761116 | 83,349,484 | The product selectivity of many heterogeneous electrocatalytic processes is profoundly affected by the liquid side of the electrocatalytic interface. The electrocatalytic reduction of CO to hydrocarbons on Cu electrodes is a prototypical example of such a process. However, probing the interactions of surface-bound inte... | 10.1038/s41929-020-00512-x | This study highlights the interactions of interfacial H 2 O with surface-bound intermediates and the effect of quaternary alkyl ammonium cations. |
10.1126/science.1209786 | 83,545,798 | Carbon dioxide reduction reactions, a key step in creating fuels from this gas, can be achieved in an ionic liquid. | 10.1038/s41929-020-00512-x | The first example of an ionic liquid additive in the electrolyte that significantly enhances CO 2 electroreduction on Ag through interactions of the ionic liquid with a catalytic intermediate. |
10.1038/s41467-019-09626-8 | 20,717,140 | Abstract The selective and efficient electrochemical reduction of CO 2 to single products is crucial for solar fuels development. Encapsulating molecular catalysts such as cobalt phthalocyanine within coordination polymers such as poly-4-vinylpyridine leads to dramatically increased activity and selectivity for CO 2 re... | 10.1038/s41929-020-00512-x | A detailed analysis of a functional polymer-encapsulation of a CO 2 RR catalyst and its effects on the chemical environment of the catalyst. |
10.1002/anie.201908058 | 101,922,124 | Abstract The photocatalytic CO 2 reduction reaction (CRR) represents a promising route for the clean utilization of stranded renewable resources, but poor selectivity resulting from the competing hydrogen evolution reaction (HER) in aqueous solution limits its practical applicability. In the present contribution a phot... | 10.1038/s41929-020-00512-x | This work describes the introduction of a hydrophobic polymer on Pt-decorated carbon nitride photocatalyst, thus concentrating CO 2 molecules in the vicinity of the catalytic site. |
10.1126/science.aay4217 | 83,487,458 | Electrolysis offers an attractive route to upgrade greenhouse gases such as carbon dioxide (CO 2 ) to valuable fuels and feedstocks; however, productivity is often limited by gas diffusion through a liquid electrolyte to the surface of the catalyst. Here, we present a catalyst:ionomer bulk heterojunction (CIBH) archite... | 10.1038/s41929-020-00512-x | This work highlights the possibilities of electrocatalytic CO 2 conversion by reaching commercially relevant current densities through chemical modification of the gas diffusion electrode ionomer. |
10.1037/1089-2680.2.3.271 | 41,730,004 | The emerging field of emotion regulation studies how individuals influence which emotions they have, when they have them, and how they experience and express them. This review takes an evolutionary perspective and characterizes emotion in terms of response tendencies. Emotion regulation is defined and distinguished fro... | 10.1038/s44159-022-00040-4 | This is a key paper for the Gross process model |
10.1146/annurev-clinpsy-032814-112739 | 83,307,832 | Emotional problems figure prominently in many clinical conditions. Recent efforts to explain and treat these conditions have emphasized the role of emotion dysregulation. However, emotional problems are not always the result of emotion dysregulation, and even when emotional problems do arise from emotion dysregulation,... | 10.1038/s44159-022-00040-4 | This is a comprehensive overview of how the process model of emotion regulation can be mapped onto psychopathology |
10.3389/fpsyt.2021.626698 | 135,090,655 | Dysregulated emotion plays an important role for mental health problems. To elucidate the underlying mechanisms, researchers have focused on the domains of strategy-based emotion regulation, psychophysiological self-regulation, emotion evaluations, and resulting emotion dynamics. So far, these four domains have been lo... | 10.1038/s44159-022-00040-4 | This article integrates various perspectives on emotion regulation to derive new avenues for future research and intervention |
10.1002/hbm.25722 | 133,762,408 | Abstract Ineffective use of adaptive cognitive strategies (e.g., reappraisal) to regulate emotional states is often reported in a wide variety of psychiatric disorders, suggesting a common characteristic across different diagnostic categories. However, the extent of shared neurobiological impairments is incompletely un... | 10.1038/s44159-022-00040-4 | This meta-analysis highlights the lack of transdiagnostic brain abnormalities related to instructed reappraisal |
10.1111/j.1745-6924.2008.00088.x | 20,856,528 | The response styles theory ( Nolen-Hoeksema, 1991 ) was proposed to explain the insidious relationship between rumination and depression. We review the aspects of the response styles theory that have been well-supported, including evidence that rumination exacerbates depression, enhances negative thinking, impairs prob... | 10.1038/s44159-022-00040-4 | This seminal review discusses the role of rumination in the development of depression |
10.1177/0272431618806053 | 29,345,861 | Emotion dysregulation has been associated with increased risks for psychopathology. During adolescence when the onset of mental illnesses peak, emotion dysregulation may be particularly problematic. In this study, we examined transactional associations between young adolescents’ self-report of their emotion dysregulati... | 10.1038/s44159-022-00040-4 | This is one of the few longitudinal studies with repeated assessments that finds associations between emotion dysregulation and internalizing symptoms in adolescents |
10.1159/000348448 | 125,107,220 | <b><i>Background:</i></b> Deficits in emotion regulation skills are possible factors maintaining major depressive disorder (MDD). Therefore, the aim of the study was to test whether integrating a systematic emotion regulation training (ERT) enhances the efficacy of routine inpatient cognitive be... | 10.1038/s44159-022-00040-4 | This is one of the few trials that tested whether adding an intervention for emotion regulation enhances effectiveness of pre-existing evidence-based approaches |
10.1111/mila.12096 | 60,915,853 | Abstract Current models of auditory verbal hallucinations (AVHs) tend to focus on the mechanisms underlying their occurrence, but often fail to address the content of the auditory experience. In other words, they tend to ask why there are AVHs at all, instead of asking why, given that there are AVHs, they have the prop... | 10.1038/s44159-021-00013-z | In this article, a philosopher and a psychologist explore some of the different ways in which hallucinated voices can take on personal, agent-like characteristics |
10.1073/pnas.2016649118 | 101,660,172 | Hearing the voice of God, feeling the presence of the dead, being possessed by a demonic spirit—such events are among the most remarkable human sensory experiences. They change lives and in turn shape history. Why do some people report experiencing such events while others do not? We argue that experiences of spiritual... | 10.1038/s44159-021-00013-z | This cross-cultural study demonstrates that absorptive tendencies, and cultural models about boundaries between the mind and the world, are associated with vivid sensory experiences of spirits |
10.1177/0956797620985832 | 103,695,021 | Hallucinatory experiences can occur in both clinical and nonclinical groups. However, in previous studies of the general population, investigations of the cognitive mechanisms underlying hallucinatory experiences have yielded inconsistent results. We ran a large-scale preregistered multisite study, in which general-pop... | 10.1038/s44159-021-00013-z | This is a large international multisite replication study of cognitive aspects associated with hallucinatory experiences in the general population |
10.1111/j.2044-8260.1985.tb01331.x | 45,432,617 | The hypothesis that hallucinators are deficient in the metacognitive skill of reality testing was tested using the methodology of signal detection theory. In Expt 1 undergraduate subjects scoring high or low on a scale measuring predisposition to hallucination were tested on an auditory signal detection task. High scor... | 10.1038/s44159-021-00013-z | This is an early study linking auditory hallucinations in clinical samples to biased performance on signal detection tasks |
10.1126/science.aan3458 | 124,697,920 | Neural mechanisms for hallucinations Pairing a stimulus in one modality (vision) with a stimulus in another (sound) can lead to task-induced hallucinations in healthy individuals. After many trials, people eventually report perceiving a nonexistent stimulus contingent on the presence of the previously paired stimulus. ... | 10.1038/s44159-021-00013-z | In this article, behavioural data and computational modelling show that both clinical and non-clinical voice-hearers are susceptible to conditioned hallucinations due to overweighted priors |
10.1038/ncomms9956 | 26,769,951 | Abstract Hallucinations are common in psychiatric disorders, and are also experienced by many individuals who are not mentally ill. Here, in 153 participants, we investigate brain structural markers that predict the occurrence of hallucinations by comparing patients with schizophrenia who have experienced hallucination... | 10.1038/s44159-021-00013-z | This structural neuroimaging study shows that hallucinations in schizophrenia can be predicted by the length of a particular fold in the medial prefrontal cortex known to be significant for source monitoring |
10.1126/science.aba0210 | 62,030,106 | Embryonic development is a complex process that is unamenable to direct observation. In this study, we implanted a window to the mouse uterus to visualize the developing embryo from embryonic day 9.5 to birth. This removable intravital window allowed manipulation and high-resolution imaging. In live mouse embryos, we o... | 10.1038/s43586-022-00168-w | This work presents a removable imaging window implanted above the uterus allowing IVM of live embryonic development in utero as well as embryonic manipulation for IVM studies. |
10.1126/sciadv.abh0363 | 126,253,148 | Intravital imaging guides a personalized medicine approach to target mechanoreciprocity in pancreatic cancer. | 10.1038/s43586-022-00168-w | This work on IVM of metastatic pancreatic cancer demonstrates that short-term FAK inhibition reduces tissue fibrosis and improves standard-of-care chemotherapy performance at primary and secondary cancer sites leading to a significant extension in pancreatic cancer survival. |
10.1126/scitranslmed.aai8504 | 104,197,455 | Fine-tuned manipulation of tumor tension and vasculature enhances response to chemotherapy and impairs metastatic spread in pancreatic cancer. | 10.1038/s43586-022-00168-w | This study uses IVM to demonstrate that fine-tuned manipulation of tissue tension and vascular patency in pancreatic cancer via ROCK inhibition can improve chemotherapy performance in the primary tumour and secondary metastases leading to a significant improvement in pancreatic cancer outcome |
10.1038/s41467-021-27308-2 | 133,522,722 | Abstract Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. CSCs display the slow-migr... | 10.1038/s43586-022-00168-w | This article uses IVM of a fluorescent reporter for stemness to determine that tumour-associated macrophages induce programmes of stemness in disseminating breast cancer cells as they intravasate, and that this stemness phenotype is carried with the cells to the secondary site of the lung. |
10.1038/s41467-022-28076-3 | 127,193,445 | Abstract Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs. Growing evidence suggests that the microenvironment of the primary tumor primes DTCs for dormant or proliferative fates. However, the manner in which this occurs remains poorly understood. Here, using the Window for High-... | 10.1038/s43586-022-00168-w | This paper uses serial IVM to track the fate of DTCs in the lung, showing that primary tumour-associated macrophages induce in DTCs a triple-threat phenotype (invasive, stem and dormant) that is carried to the lung and confers to them survival and extravasation advantages. |
10.1186/s42826-020-00044-2 | 102,912,269 | Abstract Bio-imaging is a tedious task when it concerns exploring cell functions, developmental mechanisms, and other vital processes in vivo. Single-cell resolution is challenging due to different issues such as sample size, the scattering of intact and opaque tissue, pigmentation in untreated animals, the movement of... | 10.1038/s43586-022-00168-w | This review discusses several of the common non-invasive microscopy techniques that are utilized for investigating zebrafish embryo and larvae in developmental biology. |
10.1002/wrna.1595 | 83,056,440 | Abstract The chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all ... | 10.1038/s43587-021-00058-y | Comprehensive review article on RNA modifications—great introduction for newcomers to the RNA modification field |
10.1111/acel.12753 | 61,198,921 | Summary Gene expression is dynamically regulated in a variety of mammalian physiologies. During mammalian aging, there are changes that occur in protein expression that are highly controlled by the regulatory steps in transcription, post‐transcription, and post‐translation. Although there are global profiles of human t... | 10.1038/s43587-021-00058-y | This paper maps and quantifies m 6 A modifications in peripheral blood mononuclear cells from young and old individuals and reveals a global decrease in m 6 A RNA modifications with increasing age |
10.1038/s41467-018-04617-7 | 102,229,527 | Abstract Telomerase consists of the catalytic protein TERT and the RNA TERC . Mutations in TERC are linked to human diseases, but the underlying mechanisms are poorly understood. Here we report that the RNA-binding protein HuR associates with TERC and promotes the assembly of the TERC /TERT complex by facilitating TERC... | 10.1038/s43587-021-00058-y | In the manuscript, the authors identify m 5 C modifications in TERC and demonstrate that m 5 C modifications impact telomerase activity |
10.15252/embj.201489282 | 20,780,837 | Abstract Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post‐transcriptional methylation contributes to the human disease is currently unknown. By comparing gene expression data with global cytosine‐5 RNA methylomes in patient fibro... | 10.1038/s43587-021-00058-y | In the study, the authors demonstrate a role for NSUN2-mediated m 5 C tRNA modifications and tRNA-derived fragments in modulating cellular response to stress and in neurodevelopment |
10.1093/nar/gkaa816 | 104,097,792 | Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated. Here, we found that levels of both m6A RNA methylation and the methyltransferase METTL3 were r... | 10.1038/s43587-021-00058-y | In this study, it was found that m 6 A is decreased in stem cell models of the progeroid syndromes Hutchinson–Gilford progeria syndrome and Werner syndrome |
10.1126/science.aat1471 | 82,754,183 | Many elements can be combined in the formation of high-entropy-alloy nanoparticles | 10.1038/s44160-022-00218-x | This paper provides a perspective on the synthesis of alloy nanoparticles. |
10.1002/anie.201806194 | 107,184,602 | Abstract Although aqueous synthesis of nanocrystals is advantageous in terms of the cost, convenience, environmental friendliness, and surface cleanness of the product, nanocrystals of Pt and non‐noble metal alloys are difficult to obtain with controlled morphology and composition from this synthesis owing to a huge ga... | 10.1038/s44160-022-00218-x | This paper reports a synthesis of Pt–Ni alloy nanowires under the assumption that sulfite generates active hydrogen for metal co-reduction. |
10.1126/science.abc8861 | 20,586,416 | The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277 metabolites, includ... | 10.1038/s44161-022-00120-x | Our recent work quantifying fuel use in human hearts by performing metabolomics in arterial and coronary sinus blood samples from patients undergoing elective percutaneous interventions. |
10.1002/ange.201700580 | 40,767,950 | Abstract Carbon dioxide and carbon monoxide can be electrochemically reduced to useful products such as ethylene and ethanol on copper electrocatalysts. The process is yet to be optimized and the exact mechanism and the corresponding reaction intermediates are under debate or unknown. In particular, it has been hypothe... | 10.1038/s41929-018-0182-6 | The initial observation of hydrogenated CO dimer (*OCCOH) on (100) cu using operando IR spectroscopy |
10.1002/anie.201802083 | 100,407,559 | Abstract In situ and operando spectroscopic and microscopic methods were used to gain insight into the correlation between the structure, chemical state, and reactivity of size‐ and shape‐controlled ligand‐free Cu nanocubes during CO 2 electroreduction (CO 2 RR). Dynamic changes in the morphology and composition of Cu ... | 10.1038/s41929-018-0182-6 | Dynamic morphological and chemical monitoring of Cu cubes during CO 2 RR using operando EC-AFM and EXAFS. Roughening, loss of (100) facets and loss of Cu atoms from edge and corner sites, and the reduction of CuO x species were observed, concommitant with reduced CO 2 RR activity |
10.1126/science.aao3691 | 62,052,791 | Going with the grain boundaries Bulk defects in a metal, such as grain boundaries, can create regions of increased strain at its surface that could affect its catalytic activity. Mariano et al. studied the electroreduction of CO 2 to CO on polycrystalline gold films, a reaction that competes with H 2 evolution. By anne... | 10.1038/s41929-018-0182-6 | The initial experimental demonstration of heightened CO 2 RR activity at the grain boundary using SECM, as corroborated by electron backscattering diffraction (EBSD) grain mapping |
10.1038/s41586-020-2797-4 | 62,598,710 | Abstract Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a... | 10.1038/s44161-022-00205-7 | Single-cell RNA-seq of an adult human heart reveals the distinct atrial and ventricular subsets of cells, highlighting the cellular heterogeneity of the human heart and providing an online human cardiac cell atlas for a valuable reference. |
10.1126/science.aam8940 | 20,409,072 | Sequencing each cell of the nematode Single-cell sequencing is challenging owing to the limited biological material available in an individual cell and the high cost of sequencing across multiple cells. Cao et al. developed a two-step combinatorial barcoding method to profile both single-cell and single-nucleus transcr... | 10.1038/s44161-022-00205-7 | Sci-RNA-seq, a combinatorial indexing method for profiling the transcriptomes of single cells or nuclei, was developed and profiled over 50,000 cells from the L2 larval stage of Caenorhabditis elegans , resulting in >50-fold ‘shotgun’ coverage of its somatic cell composition. |
10.1038/s41467-021-21246-9 | 20,701,256 | Abstract Understanding global communications among cells requires accurate representation of cell-cell signaling links and effective systems-level analyses of those links. We construct a database of interactions among ligands, receptors and their cofactors that accurately represent known heteromeric molecular complexes... | 10.1038/s44161-022-00205-7 | CellChat is a tool that can statistically predict and analyze intercellular communication networks using single-cell RNA-sequencing data and thereby assist in the discovery of novel intercellular communications in various tissues. |
10.1126/science.aba7721 | 62,298,724 | The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, we applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimate... | 10.1038/s44161-022-00205-7 | This study generated comprehensive atlases of early human development from two studies by Cao et al. and Domcke et al., using a pooled approach with three levels of combinatorial indexing, and examined the single-cell gene expression and chromatin landscapes of 15 organs in fetal samples. |
10.1126/science.1133755 | 83,482,776 | Cooperation is needed for evolution to construct new levels of organization. Genomes, cells, multicellular organisms, social insects, and human society are all based on cooperation. Cooperation means that selfish replicators forgo some of their reproductive potential to help one another. But natural selection implies c... | 10.1038/s43588-022-00335-9 | A review article that presents five key principles for the evolution of cooperation. |
10.1126/science.7466396 | 62,294,344 | Cooperation in organisms, whether bacteria or primates, has been a difficulty for evolutionary theory since Darwin. On the assumption that interactions between pairs of individuals occur on a probabilistic basis, a model is developed based on the concept of an evolutionarily stable strategy in the context of the Prison... | 10.1038/s43588-022-00335-9 | Highly influential paper on the success of tit-for-tat in prisoner’s dilemma experiments. |
10.1073/pnas.0709546105 | 82,977,848 | Will a group of people reach a collective target through individual contributions when everyone suffers individually if the target is missed? This “collective-risk social dilemma” exists in various social scenarios, the globally most challenging one being the prevention of dangerous climate change. Reaching the collect... | 10.1038/s43588-022-00335-9 | This paper introduces collective-risk social dilemmas and explores them experimentally. |
10.1080/03632415.2014.891503 | 81,976,728 | ABSTRACT Flow and water temperature are fundamental properties of stream ecosystems upon which many freshwater resource management decisions are based. U.S. Geological Survey (USGS) gages are the most important source of streamflow and water temperature data available nationwide, but the degree to which gages represent... | 10.1038/s41893-022-00878-9 | This paper reports biases in the landscape representation of the US Geological Survey stream gauge network |
10.1038/s41467-020-18122-3 | 16,834,172 | Abstract Microelectronic thermoelectric generators are one potential solution to energizing energy autonomous electronics, such as internet-of-things sensors, that must carry their own power source. However, thermoelectric generators with the mm 2 footprint area necessary for on-chip integration made from high thermoel... | 10.1038/s41928-022-00776-0 | This work reported µ-TEGs using Si 0.97 Ge 0.03 , made by standard Si processing, resulting in a high normalized power of 85 µ W cm −2 K −2 |
10.1126/science.aau2277 | 38,300,134 | Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve syste... | 10.1038/s44222-022-00006-4 | This article reports the design of a microneedle device that can self-orient, inspired by a leopard tortoise. |
10.1002/adma.201903793 | 20,626,230 | Abstract Spores, the dormant life forms of probiotics, can germinate to metabolically active vegetative cells with the disintegration of their hydrophobic protein coat in the intestinal microenvironment, which provides the possibility for the formation of nanoparticles (NPs) in vivo. Inspired by the natural physiologic... | 10.1038/s44222-022-00006-4 | This article shows that drug-modified Bacillus coagulans spores can autonomously produce drug nanoparticles after germination in the intestine, which contributes to drug permeation and absorption. |
10.1126/sciadv.abk1792 | 133,318,331 | We developed a dynamic omnidirectional adhesive microneedle system that improves the oral delivery of macromolecules. | 10.1038/s44222-022-00006-4 | This article reports an oral microneedle device, inspired by thorny-headed worms, which swells after penetration into the intestinal tissue, steadily attaching to the mucosa and continuously delivering drugs. |
10.1126/scitranslmed.aau8581 | 103,567,781 | We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm wa... | 10.1038/s44222-022-00006-4 | This article reports a flower-like, shape-memory, reconfigurable oesophageal delivery device that remains folded during oral administration, deploys to penetrate the mucosa and deliver drugs, and refolds upon contact with warm water. |
10.1038/s41467-017-00309-w | 103,825,930 | Abstract Advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating di... | 10.1038/s44222-022-00006-4 | This article reports clarithromycin-loaded gastric micromotors that are propelled by the gas-producing reaction of Mg and H + to release drugs in the stomach for the treatment of H. pylori infection. |
10.1002/lol2.10080 | 82,452,198 | Abstract The “freshwater pipe” concept has improved our understanding of freshwater carbon (C) cycling, however, it has rarely been applied to macronutrients such as nitrogen (N) or phosphorus (P). Here, we synthesize knowledge of the processing of C, N, and P together in freshwaters from land to the ocean. We compared... | 10.1038/s43017-019-0019-0 | Quantified changes to nutrient ratios along the land–ocean aquatic continuum, with thorough discussion of driving mechanisms |
10.1126/science.aar4462 | 41,742,921 | In August 2017, the Gulf of Mexico’s hypoxic zone was declared to be the largest ever measured. It has been estimated that a 60% decrease in watershed nitrogen (N) loading may be necessary to adequately reduce eutrophication in the Gulf. However, to date there has been no rigorous assessment of the effect of N legacies... | 10.1038/s43017-019-0019-0 | Modelled historical and predicted future nitrogen loads for the Mississippi River, indicating that legacy nitrogen loading from agriculture may prevent reduction of the Gulf of Mexico dead zone for decades |
10.1038/ncomms8373 | 41,690,175 | Abstract Weyl fermions are massless chiral fermions that play an important role in quantum field theory but have never been observed as fundamental particles. A Weyl semimetal is an unusual crystal that hosts Weyl fermions as quasiparticle excitations and features Fermi arcs on its surface. Such a semimetal not only pr... | 10.1038/s42254-021-00344-z | Weng et al. ( Phys. Rev. X , 2015) and Huang et al. ( Nat. Commun. , 2015) proposed the inversion-symmetry-breaking Weyl semimetal TaAs class |
10.1038/s41467-017-01438-y | 123,159,517 | Abstract Owing to the coupling between open Fermi arcs on opposite surfaces, topological Dirac semimetals exhibit a new type of cyclotron orbit in the surface states known as Weyl orbit. Here, by lowering the carrier density in Cd 3 As 2 nanoplates, we observe a crossover from multiple-frequency to single-frequency Shu... | 10.1038/s42254-021-00344-z | Report of quantum Hall effect in Cd 3 As 2 |
10.1038/s41467-019-10499-0 | 41,497,394 | Abstract Unconventional surface states protected by non-trivial bulk orders are sources of various exotic quantum transport in topological materials. One prominent example is the unique magnetic orbit, so-called Weyl orbit, in topological semimetals where two spatially separated surface Fermi-arcs are interconnected ac... | 10.1038/s42254-021-00344-z | This paper shows the distinct quantum Hall origins in Cd 3 As 2 films at different thickness regimes |
10.1038/s41467-021-22904-8 | 103,709,687 | Abstract Topological semimetals hosting bulk Weyl points and surface Fermi-arc states are expected to realize unconventional Weyl orbits, which interconnect two surface Fermi-arc states on opposite sample surfaces under magnetic fields. While the presence of Weyl orbits has been proposed to play a vital role in recent ... | 10.1038/s42254-021-00344-z | This paper shows the coupling between Fermi arcs of opposite surfaces in the quantum Hall state of Cd 3 As 2 |
10.1126/science.285.5430.1042 | 125,070,774 | Heating of a ruthenium surface on which carbon monoxide and atomic oxygen are coadsorbed leads exclusively to desorption of carbon monoxide. In contrast, excitation with femtosecond infrared laser pulses enables also the formation of carbon dioxide. The desorption is caused by coupling of the adsorbate to the phonon ba... | 10.1038/s41929-018-0138-x | Demonstration of unique chemical reaction outcomes for electron-mediated processes versus phonon-mediated processes on bulk metals under laser excitation |
10.1126/science.1231631 | 62,456,797 | Copper in the Spotlight Elemental copper should, in principle, be a productive catalyst for the commercial preparation of propylene oxide; however, in practice, surface oxidation under industrial conditions quickly diminishes selectivity below a useful threshold. Marimuthu et al. (p. 1590 ) now show that irradiating th... | 10.1038/s41929-018-0138-x | A unique case in which plasmon excitation causes a change in the oxidation state of a metal catalyst under operating conditions resulting in a significant improvement of product selectivity |
10.1063/1.437095 | 20,413,883 | Greatly enhanced Raman scattering from monolayers of pyridine adsorbed on silver has been reported by several authors. I propose that the anomalous intensity arises from preresonant or resonant excitations of conduction electron resonances in adsorbate covered metal bumps on the surface. The bumps form a two-dimensiona... | 10.1038/s43586-021-00083-6 | This article is the first demonstration of the role of surface plasmons in SERS |
10.1126/science.275.5303.1102 | 41,670,963 | Optical detection and spectroscopy of single molecules and single nanoparticles have been achieved at room temperature with the use of surface-enhanced Raman scattering. Individual silver colloidal nanoparticles were screened from a large heterogeneous population for special size-dependent properties and were then used... | 10.1038/s43586-021-00083-6 | This article is one of two presenting the first conceptual demonstration of single-molecule SERS |
10.1002/cyto.a.20609 | 18,144,241 | Abstract Budding yeast Saccharoymyces cerevisiae is a powerful model system for analyzing eukaryotic cell cycle regulation. Yeast cell cycle analysis is typically performed by visual analysis or flow cytometry, and both have limitations in the scope and accuracy of data obtained. This study demonstrates how multispectr... | 10.1038/s43586-022-00167-x | Cell cycle analysis using imaging flow cytometry using image properties |
10.1038/s41467-021-22035-0 | 131,169,666 | Abstract Hydrogen is one of the possible alloying elements in the Earth’s core, but its siderophile (iron-loving) nature is debated. Here we experimentally examined the partitioning of hydrogen between molten iron and silicate melt at 30–60 gigapascals and 3100–4600 kelvin. We find that hydrogen has a metal/silicate pa... | 10.1038/s43017-021-00203-6 | Experimentally determined the partitioning of hydrogen between liquid Fe and molten silicate under high pressure and high temperature corresponding to conditions of core-forming metal segregation from silicate |
10.1073/pnas.2002269117 | 81,869,687 | Extensive and recurrent severe wildfires present complex challenges for policy makers. This is highlighted by extensive wildfires around the globe, ranging from western North America and Europe to the Amazon and Arctic, and, most recently, the 2019–2020 fires in eastern Australia. In many jurisdictions, discussions aft... | 10.1038/s43247-020-00065-8 | Policy recommendations for human and natural systems impacted by Australian forest fires, including implications of frequent re-burning in some areas |
10.1029/2019gl083699 | 103,656,882 | Abstract Pyrocumulonimbus (pyroCb) wildfires cause devastation in many regions globally. Given that fire‐atmosphere coupling is associated with pyroCbs, future changes in coincident high index values of atmospheric instability and dryness (C‐Haines) and near‐surface fire weather are assessed for southeastern Australia ... | 10.1038/s43247-020-00065-8 | Detailed description of the climate and landscape factors that allow forest fires to develop into extreme (pyroCb) fires in southeast Australia |
10.1038/s41598-019-46362-x | 123,000,656 | Abstract Extreme wildfires have recently caused disastrous impacts in Australia and other regions of the world, including events with strong convective processes in their plumes (i.e., strong pyroconvection). Dangerous wildfire events such as these could potentially be influenced by anthropogenic climate change, howeve... | 10.1038/s43247-020-00065-8 | Assessment of observed and future changes in indicators for the dangerous weather conditions that promote large and extreme fires in Australia |
10.1111/j.1466-8238.2009.00512.x | 125,176,603 | ABSTRACT Aim Patterns of fire regimes across Australia exhibit biogeographic variation in response to four processes. Variations in area burned and fire frequency result from differences in the rates of ‘switching’ of biomass growth, availability to burn, fire weather and ignition. Therefore differing processes limit f... | 10.1038/s43247-020-00065-8 | Landmark conceptual paper describing variation in Australian fire regimes and key drivers both now and in the future |
10.1002/adfm.201102005 | 124,044,529 | Abstract The control of the doping ratio of a blue‐emitting matrix by an orange emitter with high accuracy still remains very challenging in the development of reproducible white organic light‐emitting diodes (WOLEDs). In this work, the development of an organophosphorus dopant that presents a high doping rate in order... | 10.1038/s41929-021-00720-z | This article describes the application of organophosphorus compounds in materials chemistry |
10.1002/anie.200904948 | 101,743,563 | Abstract Asymmetric catalysis with transition‐metal complexes is the basis for a vast array of stereoselective transformations and has changed the face of modern synthetic chemistry. Key to this success has been the design of chiral ligands to control the regio‐, diastereo‐, and enantioselectivity. Phosphoramidites hav... | 10.1038/s41929-021-00720-z | This review represents the breakthroughs in the field of asymmetric catalysis using phosphoramidite as a ligand |
10.17645/up.v1i2.609 | 124,525,904 | With the prevalence of smartphones, new ways of engaging citizens and stakeholders in urban planning and governance are emerging. The technologies in smartphones allow citizens to act as sensors of their environment, producing and sharing rich spatial data useful for new types of collaborative governance set-ups. Data ... | 10.1038/s41893-018-0153-6 | This article shows how volunteered geographic information from social media (Instagram) can be used to gain knowledge on how people interact with and perceive urban green spaces and inform future green infrastructure planning |
10.1111/gean.12081 | 104,169,090 | There has been much excitement among quantitative geographers about newly available data sets, characterized by high volume, velocity, and variety. This phenomenon is often labeled as “Big Data” and has contributed to methodological and empirical advances, particularly in the areas of visualization and analysis of soci... | 10.1038/s41893-018-0153-6 | This paper offers an approach to test the reliability of geotagged ‘big data’ from social media (Twitter) for mapping retail flows in an urban region, by using mobile phone and consumer-survey data |
10.1126/science.346.6213.1063 | 100,331,169 | Large-scale studies of human behavior in social media need to be held to higher methodological standards | 10.1038/s41893-018-0153-6 | This article offers an in-depth overview of the potential biases and flows in social-media data and how these can be reduced |
10.1002/adma.201905522 | 20,105,683 | Abstract Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges ... | 10.1038/s41928-022-00806-x | A review article that presents strategies to build a cyber–physiochemical interface that can extract biophysical and biochemical signals, and relate them to electronic, communication and computing technologies. |
10.1093/oso/9780198505921.001.0001 | 148,988,565 | Abstract An understanding of the quantum mechanical nature of magnetism has led to the development of new magnetic materials which are used as permanent magnets, sensors, and in information storage. Behind these practical applications lie a range of fundamental ideas, including symmetry breaking, order parameters, exci... | 10.1038/s42005-022-00853-y | This book provide an excellent and compact introduction to the foundational concepts of magnetism in solids |
10.1146/annurev-conmatphys-031115-011319 | 83,546,045 | Recently, the effects of spin-orbit coupling (SOC) in correlated materials have become one of the most actively studied subjects in condensed matter physics, as correlations and SOC together can lead to the discovery of new phases. Examples include unconventional magnetism, spin liquids, and strongly correlated topolog... | 10.1038/s42005-022-00853-y | This review article describes the exotic magnetic phases that can arise in the presence of strong spin-orbit coupling |
10.1126/science.1196397 | 19,136,674 | Chlorination of drinking water and municipal wastewater can create toxic chemical by-products, but alternatives pose their own set of hazards. | 10.1038/s41893-022-00901-z | A review article that presents the health risk of chlorinated DPBs |
10.1038/ncomms12512 | 104,234,482 | Abstract Van der Waals heterostructures composed of two-dimensional transition-metal dichalcogenides layers have recently emerged as a new family of materials, with great potential for atomically thin opto-electronic and photovoltaic applications. It is puzzling, however, that the photocurrent is yielded so efficiently... | 10.1038/s42254-020-00272-4 | A report of ultrafast formation of interlayer hot excitons in 2D vdW heterostructure. |
10.1038/ncomms13906 | 107,239,676 | Abstract In emerging optoelectronic applications, such as water photolysis, exciton fission and novel photovoltaics involving low-dimensional nanomaterials, hot-carrier relaxation and extraction mechanisms play an indispensable and intriguing role in their photo-electron conversion processes. Two-dimensional transition... | 10.1038/s42254-020-00272-4 | Report of slow cooling and efficient extraction of C-exciton HCs in the MoS 2 –graphene interface |
10.1126/sciadv.aax9958 | 62,514,172 | Although the unique hot carrier characteristics in graphene suggest a new paradigm for hot carrier–based energy harvesting, the reported efficiencies with conventional photothermoelectric and photothermionic emission pathways are quite low because of inevitable hot carrier thermalization and cooling loss. Here, we prop... | 10.1038/s42254-020-00272-4 | A report of ultrafast hot electron extraction before carrier thermalization in graphene heterostructures |
10.1146/annurev-arplant-050213-035715 | 103,683,164 | Natural variants of crops are generated from wild progenitor plants under both natural and human selection. Diverse crops that are able to adapt to various environmental conditions are valuable resources for crop improvements to meet the food demands of the increasing human population. With the completion of reference ... | 10.1038/s42003-021-02782-y | The article illustrates how the advances in high-throughput sequencing technology will facilitate efficient use of crop diversity in the crop designs via genomics-assisted breeding |
10.1111/pbi.12456 | 60,748,123 | Summary High‐resolution genome analysis technologies provide an unprecedented level of insight into structural diversity across crop genomes. Low‐cost discovery of sequence variation has become accessible for all crops since the development of next‐generation DNA sequencing technologies, using diverse methods ranging f... | 10.1038/s42003-021-02782-y | This review illustrates the role of next-generation sequencing and high-throughput SNP genotyping platforms in harnessing the untapped potential of crop diversity in crop improvement |
10.1111/pbi.13087 | 107,179,084 | Summary Though several genes governing various major traits have been reported in rice, their superior haplotype combinations for developing ideal variety remains elusive. In this study, haplotype analysis of 120 previously functionally characterized genes, influencing grain yield (87 genes) and grain quality (33 genes... | 10.1038/s42003-021-02782-y | This study identifies the superior haplotypes for the traits related to grain yield and quality in rice using 3K genome panel and highlights the importance of haplotype-based breeding for developing next-generation tailor-made rice with superior haplotype combinations of target genes |
10.1534/g3.117.300548 | 67,422,005 | Abstract Genome-wide prediction approaches represent versatile tools for the analysis and prediction of complex traits. Mostly they rely on marker-based information, but scenarios have been reported in which models capitalizing on closely-linked markers that were combined into haplotypes outperformed marker-based model... | 10.1038/s42003-021-02782-y | This study demonstrates the higher prediction accuracies of haplotype-based model (HGBLUP) in comparison to marker-based models for the traits in a mouse panel, which suggests a great potential of haplotype-based breeding in genomic prediction |
10.1038/s41467-020-18683-3 | 122,506,082 | Abstract Genetic variation is of crucial importance for crop improvement. Landraces are valuable sources of diversity, but for quantitative traits efficient strategies for their targeted utilization are lacking. Here, we map haplotype-trait associations at high resolution in ~1000 doubled-haploid lines derived from thr... | 10.1038/s42003-021-02782-y | The study identifies the haplotype-trait associations in ~1000 doubled haploid maize lines for early development traits and demonstrates that haplotype-based strategy has great potential for improving quantitative traits from genetic resources |
10.1002/tpg2.20009 | 60,876,722 | Abstract Successful management and utilization of increasingly large genomic datasets is essential for breeding programs to accelerate cultivar development. To help with this, we developed a Sorghum bicolor Practical Haplotype Graph (PHG) pangenome database that stores haplotypes and variant information. We developed t... | 10.1038/s42003-021-02782-y | The Sorghum bicolor Practical Haplotype Graph (PHG) pangenome database, developed in this study demonstrated its utility in research and breeding |
10.3390/s17112680 | 17,453,689 | Surface Plasmon Resonance (SPR) is a powerful technique to study the kinetics of biomolecules undergoing biorecognition processes, particularly suited for protein-protein interactions of biomedical interest. The potentiality of SPR was exploited to sense the interactions occurring within the network of the tumor suppre... | 10.1038/s43588-022-00230-3 | This paper reports that the NP and protein interaction process in real-time can occur on a timescale of up to several minutes |
10.1126/science.1242477 | 83,056,105 | Solutions for nanoparticle solutions Nanoparticle interactions in solution affect their binding to biomolecules, their electronic properties, and their packing into larger crystals. However, the theories that describe larger colloidal particles fail for nanoparticles, because the interactions do not add together linear... | 10.1038/s43588-022-00230-3 | This paper dissects the complexity of nanoscale macromolecules, including proteins and NPs |
10.1126/science.1190094 | 83,431,858 | Inorganic nanoparticles coated with organic films can display surface chemistries that allow them to function like globular proteins. | 10.1038/s43588-022-00230-3 | A foundational perspective article that presents inorganic NPs as protein mimics |
10.1038/s41591-020-0844-1 | 62,137,560 | Abstract Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq (snRNA-Seq) is needed to profile frozen or hard-to-dissociate tumors. Each requires customization to different tissue and tumor typ... | 10.1038/s42255-021-00417-4 | Slyper et al. describe multiple practical workflows for performing single-cell and single-nucleus transcriptome analyses |
10.1101/791699 | 41,218,110 | Abstract Droplet-based scRNA-seq assays are known to produce a significant amount of background RNA counts, the hallmark of which is non-zero transcript counts in presumably empty droplets. The presence of background RNA can lead to systematic biases and batch effects in various downstream analyses such as differential... | 10.1038/s42255-021-00417-4 | Fleming et al. develop a machine-learning algorithm to remove ambient RNA and exclude empty droplets in scRNA-seq datasets |
10.1002/2013jf002997 | 27,916,061 | Abstract Bedrock river valleys are fundamental components of many landscapes, and their morphologies—from slot canyons with incised meanders to wide valleys with strath terraces—may record environmental history. Several formation mechanisms for particular valley types have been proposed that involve changes in climatic... | 10.1038/s43017-020-0096-0 | Proposes criteria to identify autogenically generated river terraces using a numerical model and field data |
10.1126/science.1248765 | 125,297,520 | Introduction River networks, the backbone of most landscapes on Earth, collect and transport water, sediment, organic matter, and nutrients from upland mountain regions to the oceans. Dynamic aspects of these networks include channels that shift laterally or expand upstream, ridges that migrate across Earth’s surface, ... | 10.1038/s43017-020-0096-0 | Highlights the ubiquity of river-basin reorganization and proposes a framework to understand primary causes and a means to visualize recent and likely future reorganization |
10.1029/2010gl044638 | 124,984,108 | Landscapes respond to climate, tectonic motions and sea level, but this response is mediated by sediment transport. Understanding transmission of environmental signals is crucial for predicting landscape response to climate change, and interpreting paleo‐climate and tectonics from stratigraphy. Here we propose that sed... | 10.1038/s43017-020-0096-0 | Documents how sediment transport can filter or ‘shred’ signals from perturbations in external forcing during source-to-sink transport |
10.1146/annurev-earth-063016-015935 | 61,887,674 | Internally generated, or autogenic, terrestrial and marine sediment-transport dynamics can produce depositional patterns similar to those associated with climatic, tectonic, or sea level changes. A central challenge in accurately interpreting the sedimentary archive is determining what scales and types of deposits refl... | 10.1038/s43017-020-0096-0 | Reviews autogenic dynamics in depositional landscapes and the sedimentary record |
10.1029/94jb00857 | 80,746,688 | Along three rivers at the Mendocino triple junction, northern California, strath, cut, and fill terraces have formed in response to tectonic and eustatic processes. Detailed surveying and radiometric dating at multiple sites indicate that lower reaches of the rivers are dominated by the effects of oscillating sea level... | 10.1038/s43017-020-0096-0 | Separates competing mechanisms for terrace formation, including sea-level change, tectonic uplift and autogenic river migration |
10.1002/2016jf003973 | 62,426,648 | Abstract Efforts to extract information about climate and tectonics from topography commonly assume that river networks are static. Drainage divides can migrate through time, however, and recent work has shown that divide mobility can potentially induce changes in river profiles comparable to changes caused by variatio... | 10.1038/s43017-020-0096-0 | Explores how the ratio of divide-migration rate to river-channel-adjustment rate sets landscape topographic form |
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