source_doi stringlengths 13 57 | source_mag_paper_id int64 490k 157M | source_abstract stringlengths 8 10.7k | target_doi stringlengths 14 27 | target_summary stringlengths 42 889 |
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10.1523/jneurosci.21-12-04249.2001 | 19,248,086 | Brain-derived neurotrophic factor (BDNF) is emerging as a key mediator of activity-dependent modifications of synaptic strength in the CNS. We investigated the hypothesis that BDNF enhances quantal neurotransmitter release by modulating the distribution of synaptic vesicles within presynaptic terminals using organotypi... | 10.1038/nrn988 | Evidence that BDNF increases the number of docked vesicles at hippocampal excitatory synapses and the frequency of AMPA-mediated EPSCs. |
10.1523/jneurosci.21-22-08789.2001 | 103,220,454 | Neurotrophin-3 (NT-3), its cognate receptor trkC, and voltage-gated calcium channels are coexpressed by embryonic pyramidal neurons before target contact, but their functions at this stage of development are still unclear. We show here that, in vitro , anti-NT-3 and anti-trkC antibodies blocked the increase, and NT-3 r... | 10.1038/nrn988 | This study shows that NT3 regulates the differentiation of hippocampal pyramidal neurons through an autocrine loop. |
10.1523/jneurosci.18-18-07256.1998 | 102,228,715 | Cell cultures were used to analyze the role of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the development of synaptic transmission. Neurons obtained from embryonic day 18 (E18) rat hippocampus and cultured for 2 weeks exhibited extensive spontaneous synaptic activity. By comparison, neurons o... | 10.1038/nrn988 | The first results to show that neurotrophins are involved in the transformation of presynaptically silent synapses into functional ones. |
10.1046/j.0953-816x.2001.01500.x | 16,735,895 | Abstract We have recently demonstrated that embryonic E16 hippocampal neurons grown in cultures are unable to form fast synaptic connections unless treated with BDNF or NT‐3. This experimental system offers an opportunity to define the roles of neurotrophins in processes leading to formation of functional synaptic conn... | 10.1038/nrn988 | Evidence that BDNF and NT3 increase the number of docked vesicles at hippocampal excitatory synapses, and the frequency of AMPA-mediated EPSCs. |
10.1523/jneurosci.19-12-04972.1999 | 82,934,217 | Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during high-frequency stimulation (HFS). Here we have investigated the mechanisms of BDNF action using two lines of BDNF knockout mice. Among other presynaptic... | 10.1038/nrn988 | An electrophysiological, structural and molecular analysis of the effects of targeted deletion of Bdnf on hippocampal synapses. |
10.1523/jneurosci.20-09-03221.2000 | 123,536,784 | Brain-derived neurotrophic factor (BDNF) has been postulated to be a key signaling molecule in regulating synaptic strength and overall circuit activity. In this context, we have found that BDNF dramatically increases the frequency of spontaneously initiated action potentials in hippocampal neurons in dissociated cultu... | 10.1038/nrn988 | A study showing that long-term BDNF treatment potentiates excitatory and inhibitory neurotransmission through different mechanisms. |
10.1073/pnas.122623799 | 60,501,405 | Synaptic vesicles must be primed to fusion competence before they can fuse with the plasma membrane in response to increased intracellular Ca 2+ levels. The presynaptic active zone protein Munc13-1 is essential for priming of glutamatergic synaptic vesicles in hippocampal neurons. However, a small subpopulation of syna... | 10.1038/nrn988 | These two in vivo studies (references 127 and 128) show that synaptogenesis occurs in the absence of spontaneous and evoked activity. |
10.1242/dev.124.18.3575 | 20,786,017 | Neuregulin (also known as NDF, heregulin, ARIA, GGF or SMDF), induces cell growth and differentiation. Biological effects of neuregulin are mediated by members of the erbB family of tyrosine kinase receptors. Three major neuregulin isoforms are produced from the gene, which differ substantially in sequence and in overa... | 10.1038/nrn2392 | This study was the first to show that NRG1 isoforms have distinct functions in neural development. Type I NRG1 is required for the generation of neural-crest-derived neurons in the cranial ganglia, whereas Type III NRG1 has an important role in glial-cell development. |
10.1083/jcb.200212085 | 45,566,370 | Transmembrane isoforms of neuregulin-1 (Nrg-1), ligands for erbB receptors, include an extracellular domain with an EGF-like sequence and a highly conserved intracellular domain (ICD) of unknown function. In this paper, we demonstrate that transmembrane isoforms of Nrg-1 are bidirectional signaling molecules in neurons... | 10.1038/nrn2392 | This was the first report to indicate a role for NRG1 in backward signalling. Binding of the extracellular domains of ErbB receptors and NRG1 elicits proteolytic release and the translocation of NRG1-ICD to the nucleus. |
10.1073/pnas.0602002103 | 80,157,352 | Genetic variation in neuregulin 1 ( NRG1 ) is associated with schizophrenia. The disease-associated SNPs are noncoding, and their functional implications remain unknown. We hypothesized that differential expression of the NRG1 gene explains its association to the disease. We examined four of the disease-associated SNPs... | 10.1038/nrn2392 | In this study, Type I NRG1 mRNA was found to be upregulated in the hippocampus of patients with schizophrenia, suggesting that the association of NRG1 with schizophrenia might be mediated by altered expression of the gene. |
10.1002/ajmg.b.30275 | 62,111,297 | Abstract Neuregulin 1 ( NRG1 ) has been found to be associated with schizophrenia in several populations. Consistently, mutant mice heterozygous for either NRG1 or its receptor, ErbB4 , show a behavioral phenotype that overlaps with mouse models for schizophrenia. These observations raised the hypothesis that impaired ... | 10.1038/nrn2392 | This paper compared the expression of ErbB4 isoforms in the dorsolateral prefrontal cortex (DLPFC) of controls and patients with schizophrenia and showed that the CYT-1 and JMa isoforms are overexpressed at the mRNA level in the DLPFC of schizophrenia patients. |
10.1126/science.282.5389.746 | 102,608,085 | A fundamental question in cognitive science is whether animals can represent numerosity (a property of a stimulus that is defined by the number of discriminable elements it contains) and use numerical representations computationally. Here, it was shown that rhesus monkeys represent the numerosity of visual stimuli and ... | 10.1038/nrn.2016.40 | Using painstakingly controlled visual stimuli and elegant protocols, this seminal behavioural study showed that monkeys grasp the cardinal and ordinal meaning of numbers. |
10.1126/science.1072493 | 83,022,761 | Deriving the quantity of items is an abstract form of categorization. To explore it, monkeys were trained to judge whether successive visual displays contained the same quantity of items. Many neurons in the lateral prefrontal cortex were tuned for quantity irrespective of the exact physical appearance of the displays.... | 10.1038/nrn.2016.40 | This was the first report of neurons in the PFC responding to the number of visual items monkeys were trained to discriminate. |
10.1152/jn.01014.2009 | 41,156,869 | A previous study identified neuronal activity in area 5 of the monkey posterior parietal cortex that reflects the numerosity of a series of self-performed actions. It is not known, however, whether area 5 is crucially involved in the selection of an action based on numerical information or, instead, merely reflects num... | 10.1038/nrn.2016.40 | Transient pharmacological inactivation of neuronal activity in parietal area 5 prevented monkeys from performing the correct number of movements, while sparing general motor functions and action selection. This demonstrates that the activity of number neurons is causally related to number estimation. |
10.1073/pnas.1204580109 | 20,829,150 | Numerosity, the number of elements in a set, is a most abstract quantitative category. As such, it is independent of the sensory modality of its elements, i.e., supramodal. Because neuronal numerosity selectivity had never been compared directly across different sensory modalities, it remained elusive if and where sing... | 10.1038/nrn.2016.40 | Neurons in the PFC encode the same number of visual or auditory events in behaving monkeys. |
10.1073/pnas.1308141110 | 20,805,716 | “Sense of number” refers to the classical idea that we perceive the number of items (numerosity) intuitively. However, whether the brain signals numerosity spontaneously, in the absence of learning, remains unknown; therefore, we recorded from neurons in the ventral intraparietal sulcus and the dorsolateral prefrontal ... | 10.1038/nrn.2016.40 | Visual number neurons were spontaneously present in monkeys that had never been trained to judge numerosity, arguing that the primate brain is hard-wired to assess numerical quantity. |
10.1098/rspb.2014.1791 | 19,880,147 | Much evidence has accumulated to suggest that many animals, including young human infants, possess an abstract sense of approximate quantity, a number sense . Most research has concentrated on apparent numerosity of spatial arrays of dots or other objects, but a truly abstract sense of number should be capable of encod... | 10.1038/nrn.2016.40 | Impressive psychophysical experiments reporting the generalization of number adaptation across modalities and spatio-temporal formats, suggesting a perceptual system to encode an abstract sense of number. |
10.1073/pnas.0909180107 | 79,988,598 | Mathematics is based on highly abstract principles, or rules, of how to structure, process, and evaluate numerical information. If and how mathematical rules can be represented by single neurons, however, has remained elusive. We therefore recorded the activity of individual prefrontal cortex (PFC) neurons in rhesus mo... | 10.1038/nrn.2016.40 | Populations of rule-selective neurons in the PFC of behaving monkeys signal abstract 'greater-than' or 'fewer-than' rules applied to numbers. |
10.1073/pnas.1504245112 | 122,949,769 | It is unknown whether anatomical specializations in the endbrains of different vertebrates determine the neuronal code to represent numerical quantity. Therefore, we recorded single-neuron activity from the endbrain of crows trained to judge the number of items in displays. Many neurons were tuned for numerosities irre... | 10.1038/nrn.2016.40 | This was the first study reporting number neurons in a non-mammalian species, and a species without a neocortex: the crow. |
10.1126/science.7792602 | 83,368,608 | Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an anim... | 10.1038/nrn1256 | The authors generated a model in which 5-HT levels are dramatically increased in the brain during development. Furthermore, mice lacking Maoa exhibit aggressive behaviours, comparable to patients with a mutation of MAOA. |
10.1242/dev.102.4.709 | 125,156,886 | The possible involvement of the neurotransmitter serotonin (5-HT) in morphogenesis of the craniofacial region in the mouse embryo has been investigated using the method of whole-embryo culture. Day-12 embryos were incubated for 3–4 h in the presence of 5-HT or its precursors L-tryptophan (L-TRP) or 5-hydroxytryptophan ... | 10.1038/nrn1256 | This paper was one of the first to describe sites of storage of 5-HT in cells that do not produce it, and to suggest the importance of these storage sites for controlling 5-HT levels during development. |
10.1073/pnas.84.12.4322 | 19,792,428 | The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites. In neonatal rat, a transient, dense, serotonergic innervation appears in all primary sensory areas of cortex. In somatos... | 10.1038/nrn1256 | This striking description of transient 5-HT innervation patterns in the primary sensory cortex incited a number of research groups, including our own, to work on this subject. |
10.1126/science.1083328 | 83,449,212 | Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A rece... | 10.1038/nrn1256 | This paper addresses the issue of the effects of 5-HT on adult neurogenesis by genetic approaches, and demonstrates the crucial role of the 5-HT 1A receptor in this process. |
10.1073/pnas.90.1.153 | 63,445,155 | Serotonin (5-HT)-immunoreactive axons are densely distributed in the primary visual and somatosensory cortices of rats, mice, and hamsters for the first 2 weeks of life, and a recent study from this laboratory has demonstrated that 5-HT1B receptors assume a pattern that exactly matches that of the serotoninergic axons.... | 10.1038/nrn1256 | The first clear demonstration of transient expression of a 5-HT receptor subtype on a well-defined neuronal population and during a sensitive developmental time window. |
10.1073/pnas.97.17.9508 | 102,368,599 | Several lines of evidence suggest that the serotonin (5-hydroxytryptamine, 5-HT) regulates cardiovascular functions during embryogenesis and adulthood. 5-HT binds to numerous cognate receptors to initiate its biological effects. However, none of the 5-HT receptor disruptions in mice have yet resulted in embryonic defec... | 10.1038/nrn1256 | The role of 5-HT 2B receptors in early development received a clear demonstration with this knockout mouse that displayed altered development of the heart. |
10.1126/science.1585177 | 38,785,086 | The long-term facilitation of synaptic efficacy that is induced by serotonin in dissociated cell cultures of sensory and motor neurons of Aplysia is accompanied by the growth of new synaptic connections. This growth is associated with a down-regulation in the sensory neuron of Aplysia cell adhesion molecules (apCAMs). ... | 10.1038/nrn1256 | The developmental role of 5-HT in mammals can be understood through a series of papers on the effects of 5-HT on plasticity in Aplysia . This paper is particularly relevant in this respect because it offers a mechanism to explain how 5-HT could promote axon growth. |
10.1126/science.8211186 | 41,561,421 | Genetic and metabolic studies have been done on a large kindred in which several males are affected by a syndrome of borderline mental retardation and abnormal behavior. The types of behavior that occurred include impulsive aggression, arson, attempted rape, and exhibitionism. Analysis of 24-hour urine samples indicate... | 10.1038/nrn1256 | This study provided evidence that MAOA, a key enzyme in the degradation pathway of 5-HT, could have a role in social behaviour in humans. A single point mutation in the gene led to enhanced impulsive and aggressive behaviour in affected patients. |
10.1126/science.1072290 | 26,771,260 | We studied a large sample of male children from birth to adulthood to determine why some children who are maltreated grow up to develop antisocial behavior, whereas others do not. A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A ( MAOA ) was found to moderate t... | 10.1038/nrn1256 | In the wake of the previous family case, this broader survey of MAOA gene polymorphisms underlined the intricacies of genotype and environment for determining the developmental role of 5-HT. |
10.1126/science.1222482 | 45,562,253 | On the Receiving End One type of neuron, the hippocampal pyramidal neuron, forms two different types of synapses with two different downstream partners. When the partner is an oriens-lacunosum moleculare (O-LM) interneuron, the pyramidal neuron only releases its synaptic vesicles with a low probability. When the cell o... | 10.1038/nrn.2015.3 | This paper shows that cell type-specific expression of the postsynaptic LRR protein ELFN1 instructs target cell-specific presynaptic release properties at CA1 pyramidal cell–interneuron synapses. |
10.1186/1758-2652-13-40 | 36,294,316 | Background An effective tuberculosis (TB) control programme requires early diagnosis and immediate initiation of treatment. Any delays in diagnosing TB not only impair a patient's prognosis, but also increase the risks of transmitting the disease within the community. Unfortunately, the most recent TB diagnostic tools ... | 10.1038/nrmicro2521 | This article discusses the desired specifications for new TB tests that will improve access to treatment for patients in resource-limited settings. |
10.1126/science.285.5424.110 | 20,398,192 | An estimated 170 million persons worldwide are infected with hepatitis C virus (HCV), a major cause of chronic liver disease. Despite increasing knowledge of genome structure and individual viral proteins, studies on virus replication and pathogenesis have been hampered by the lack of reliable and efficient cell cultur... | 10.1038/nrmicro3046 | The first description of a functional HCV replicon capable of efficient self-amplification in cultured human hepatoma cells. |
10.1126/science.1113329 | 62,604,554 | MicroRNAs are small RNA molecules that regulate messenger RNA (mRNA) expression. MicroRNA 122 (miR-122) is specifically expressed and highly abundant in the human liver. We show that the sequestration of miR-122 in liver cells results in marked loss of autonomously replicating hepatitis C viral RNAs. A genetic interact... | 10.1038/nrmicro3046 | The identification of miR-122 as an important HCV replication-promoting host cell factor, laying the foundation for the clinical development of miR-122-antagonizing compounds. |
10.1126/science.1178178 | 62,449,592 | The liver-expressed microRNA-122 (miR-122) is essential for hepatitis C virus (HCV) RNA accumulation in cultured liver cells, but its potential as a target for antiviral intervention has not been assessed. We found that treatment of chronically infected chimpanzees with a locked nucleic acid (LNA)–modified oligonucleot... | 10.1038/nrmicro3046 | Work assessing the antiviral activity of miR-122-antagonizing compounds in HCV-infected chimpanzees. |
10.1126/science.2523562 | 41,758,021 | A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis (NANBH) agent and screened with serum from a patient diagnosed with NANBH. A complementary DNA clone was isolated that was shown to encode an antigen associated specifically with NANBH infections.... | 10.1038/nrmicro3046 | A landmark paper that describes the first molecular clone of HCV and paves the way for the development of diagnostic tests, as well as basic and translational HCV research. |
10.1073/pnas.0832180100 | 107,386,429 | HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (strain H and Con1) are infectious for the human hepatoma cell lines Huh-7 and PLC/PR5. Infectivity depends on coexpression of both E1 and E2 glycoproteins, is pH-dependent, and can be neutralized by mAbs mapping to amino acids 412–447 within E2. Cell... | 10.1038/nrmicro3046 | References 144 and 145 describe the HCV pseudoparticle (HCVpp) system for the first time. |
10.1126/science.1114016 | 104,343,658 | Many aspects of the hepatitis C virus (HCV) life cycle have not been reproduced in cell culture, which has slowed research progress on this important human pathogen. Here, we describe a full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc). Replication of HCVcc ... | 10.1038/nrmicro3046 | A paper that describes the establishment of the HCVcc system by using a JFH-1-derived chimeric HCV genome. |
10.1073/pnas.0503596102 | 104,023,583 | The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone a... | 10.1038/nrmicro3046 | A description of the HCVcc system and the increase of viral titres by long-term cell culture passage. |
10.1073/pnas.1000985107 | 40,672,734 | The neuropeptide oxytocin enhances the processing of positive social stimuli and improves the capacity to effectively attend the eye region of conspecifics. To investigate the neural basis of these effects, we combined intranasal oxytocin administration with high-resolution functional magnetic resonance imaging in a un... | 10.1038/nrn3044 | This study used high-resolution fMRI to investigate valence-related and attentional effects of OXT on amygdala subregions in humans. Intranasal OXT had differential effects, attenuating activation in lateral and dorsal regions of the anterior amygdala for fearful faces but enhancing activity for happy expressions, sugg... |
10.1073/pnas.0600406103 | 81,336,211 | Arginine vasopressin (AVP) and related peptides affect social behaviors in numerous species, but AVP influences on human social functions have not yet been established. Here, we describe how intranasal AVP administration differentially affects social communication in men and women, and we propose a mechanism through wh... | 10.1038/nrn3044 | This study shows that AVP has different effects on human social communication in men and women. In men, AVP stimulated agonistic facial motor patterns in response to the faces of unfamiliar men, with decreased perceptions of the friendliness of these faces; in women, AVP stimulated affiliative facial motor patterns in ... |
10.1073/pnas.0909579106 | 20,736,094 | Oxytocin, a peptide that functions as both a hormone and neurotransmitter, has broad influences on social and emotional processing throughout the body and the brain. In this study, we tested how a polymorphism (rs53576) of the oxytocin receptor relates to two key social processes related to oxytocin: empathy and stress... | 10.1038/nrn3044 | This work shows that healthy carriers of a risk variant for autism in the OXTR gene have lower empathy and higher stress reactivity, and therefore exhibit key behavioural features that are also found in ASD. |
10.1073/pnas.1003296107 | 123,017,311 | The evolutionarily highly conserved neuropeptide oxytocin is a key mediator of social and emotional behavior in mammals, including humans. A common variant (rs53576) in the oxytocin receptor gene ( OXTR ) has been implicated in social-behavioral phenotypes, such as maternal sensitivity and empathy, and with neuropsychi... | 10.1038/nrn3044 | In this study, the authors show that common genetic variants in OXTR that have been associated with autism, are also linked to variations in hypothalamic, amygala and cingulate structure and function in healthy subjects. This is consistent with findings in autism and overlaps with a previously defined circuit for genet... |
10.1073/pnas.1305623110 | 83,540,084 | Significance This study shows that neurodegenerative changes induced by α-synuclein in midbrain dopamine neurons in vivo can be blocked through activation of the autophagy-lysosome pathway. Using an adeno-associated virus model of Parkinson disease to overexpress α-synuclein in the substantia nigra, we show that geneti... | 10.1038/nrn3961 | This study shows that overexpression of α -synuclein in rat midbrain results in a mislocalization of TFEB and the degeneration of dopaminergic neurons. This degeneration could be rescued by inducing autophagy via overexpression of TFEB or treatment with the rapamycin analogue CCI-779. |
10.1083/jcb.200809125 | 83,513,758 | Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease. Although the role of Parkin in neuron maintenance is unknown, recent work has linked Parkin to the regulation of mitochondria. Its loss is associated with swollen mitochondri... | 10.1038/nrn3961 | This pioneering paper linked Parkin to mitophagy for the first time and led to the subsequent surge in understanding of the potential roles of certain genes that are mutated in PD. |
10.1126/science.1101738 | 82,980,469 | Aberrant α-synuclein degradation is implicated in Parkinson's disease pathogenesis because the protein accumulates in the Lewy inclusion bodies associated with the disease. Little is known, however, about the pathways by which wild-type α-synuclein is normally degraded. We found that wild-type α-synuclein was selective... | 10.1038/nrn3961 | This landmark paper is the first to suggest the possibility of dysfunction in CMA as a factor in the pathogenesis of PD. |
10.1073/pnas.1209577109 | 101,136,266 | The role of astrocytes in neurodegenerative processes is increasingly appreciated. Here we investigated the contribution of astrocytes to neurodegeneration in multiple sulfatase deficiency (MSD), a severe lysosomal storage disorder caused by mutations in the sulfatase modifying factor 1 ( SUMF1 ) gene. Using Cre/Lox mo... | 10.1038/nrn3961 | This paper demonstrates that astrocyte-specific deletion of Sumf1 in mice, a gene associated with multiple sulfatase deficiency, results in the loss of autophagy function in astrocytes and degeneration of cortical neurons. |
10.1073/pnas.121094298 | 38,267,901 | Aeolian dust (windblown silt and clay) is an important component in arid-land ecosystems because it may contribute to soil formation and furnish essential nutrients. Few geologic surfaces, however, have been characterized with respect to dust-accumulation history and resultant nutrient enrichment. We have developed a c... | 10.1038/nrmicro2831 | This work highlights the role of SRSCs in the capture and retention of desert dust. |
10.1111/j.1365-2745.2008.01388.x | 62,109,088 | Summary Arid ecosystems are a patch mosaic of plants and biological soil crusts that have been described as islands and mantles of fertility, respectively. To determine whether these patches are metabolically linked by a fungal network of dark septate and arbuscular mycorrhizal fungi (AMF), we measured translocation of... | 10.1038/nrmicro2831 | This article demonstrates the crucial role of SRSCs in carbon and nitrogen transfer to plant communities. |
10.1073/pnas.0913139107 | 60,235,732 | The waters of the Colorado River serve 27 million people in seven states and two countries but are overallocated by more than 10% of the river’s historical mean. Climate models project runoff losses of 7–20% from the basin in this century due to human-induced climate change. Recent work has shown however that by the la... | 10.1038/nrmicro2831 | This report illustrates the fact that disturbance of desert SRSCs can lead to regional-scale disturbances in hydrology. |
10.1242/dev.125.24.5079 | 20,734,578 | The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidu... | 10.1038/nrn989 | This paper and reference 39 show that the Shh effects in the telencephalon are dependent on timing rather than on Shh concentration |
10.1242/dev.129.21.4963 | 20,673,490 | Considerable data suggest that sonic hedgehog (Shh) is both necessary and sufficient for the specification of ventral pattern throughout the nervous system, including the telencephalon. We show that the regional markers induced by Shh in the E9.0 telencephalon are dependent on the dorsoventral and anteroposterior posit... | 10.1038/nrn989 | This paper shows that in the absence of both Shh (or Smo ) and Gli3 gene activity, general aspects of DV patterning in the telencephalon are established, indicating that a Shh -independent pathway acts in the establishment of DV patterning in the telencephalon |
10.1101/gad.12.22.3603 | 19,021,820 | The Drosophila CNS develops from three columns of neuroectodermal cells along the dorsoventral (DV) axis: ventral, intermediate, and dorsal. In this and the accompanying paper, we investigate the role of two homeobox genes, vnd and ind , in establishing ventral and intermediate cell fates within the Drosophila CNS. Dur... | 10.1038/nrn989 | This work, together with references 69 and 71, shows that there is conservation in the genes that establish ventral identity in the Drosophila and vertebrate central nervous system |
10.1242/dev.126.15.3359 | 62,589,191 | The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum). Within the telencephalon, the anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in ... | 10.1038/nrn989 | This paper reports the remarkable finding that MGE (ventral-most telencephalic fate) is transformed into LGE (lateral telencephalic fate) in the absence of Nkx2.1 gene function |
10.1242/dev.128.4.527 | 62,287,173 | This study addresses the role of Sonic hedgehog (Shh) in promoting the generation of oligodendrocytes in the mouse telencephalon. We show that in the forebrain, expression of the early oligodendrocyte markers Olig2, plp/dm20 and PDGFR(alpha) corresponds to regions of Shh expression. To directly test if Shh can induce t... | 10.1038/nrn989 | This paper and reference 82 show that Shh is involved in the generation of oligodendrocytes in the telencephalon, and that, like interneurons, many cortical oligodendrocytes probably originate in the ventral telencephalon |
10.1126/science.278.5337.474 | 60,985,659 | Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, γ-aminobutyric acid (GABA)–expressing cells migrate in vitro from the subcortical ... | 10.1038/nrn989 | Provided the proof that Dlx-expressing cortical interneurons originate in ventral regions of the telencephalon |
10.1111/j.1469-7793.1998.881bj.x | 41,444,624 | EPSCs were recorded under whole‐cell voltage clamp at room temperature from Purkinje cells in slices of cerebellum from 12‐ to 14‐day‐old rats. EPSCs from individual climbing fibre (CF) inputs were identified on the basis of their large size, paired‐pulse depression and all‐or‐none appearance in response to a graded st... | 10.1038/nrn705 | A comprehensive study of presynaptic depression at a giant mammalian synapse that shows severe depression in P12–P14 rats. Release probability was heterogeneous and high at rest, but fell markedly during high-frequency stimulation (10 Hz). |
10.1113/jphysiol.1994.sp020303 | 27,018,761 | 1. An in vitro brainstem slice preparation of the superior olivary complex has been developed permitting patch recording from a presynaptic terminal (calyx of Held) and from its postsynaptic target‐‐the principal neurone of the medial nucleus of the trapezoid body (MNTB). 2. The fluorescent stain DiI (1,1'‐dioctadecyl‐... | 10.1038/nrn705 | The first patch-clamp recordings from a mammalian nerve terminal. Constant current injection showed that the calyx could fire multiple action potentials. In contrast, the principal (postsynaptic) cell fired only once. |
10.1113/jphysiol.1995.sp021095 | 4,632,603 | 1. Simultaneous whole‐cell recordings in a rat brain slice preparation are described from presynaptic terminals (calyces of Held) and postsynaptic somata which form an axosomatic synapse in the medial nucleus of the trapezoid body (MNTB). 2. Presynaptic action potentials evoked suprathreshold excitatory postsynaptic po... | 10.1038/nrn705 | The first paired recordings from the calyx and principal cell of the MNTB. Presynaptic calcium buffering capacity was surprisingly lower than that of hair cells. |
10.1098/rspb.1987.0049 | 100,793,553 | The naturally occurring progesterone metabolites 5β-pregnan-3α-ol-20- one and 5β-pregnane-3, 20-dione reversibly enhance membrane currents elicited by locally applied GABA in bovine adrenomedullary chromaffin cells. Such potentiation was not influenced by the benzodiazepine antagonist Ro 15-1788. At concentrations in e... | 10.1038/nrn1703 | In this study, single-channel recordings show that low concentrations of certain progesterone metabolites prolong the open state of the GABA-gated ion channel and, at slightly greater concentrations, directly activate the receptor. |
10.1523/jneurosci.0075-04.2004 | 42,507,841 | An interaction with the GABA type A (GABA A ) receptor has long been recognized as one of the main neurochemical mechanisms underlying many of the pharmacological actions of ethanol. However, more recent data have suggested that certain behavioral and electrophysiological actions of ethanol are mediated by an increase ... | 10.1038/nrn1703 | This paper presents electrophysiological evidence that the influence of ethanol and GHB on inhibitory transmission might be mediated, in part, by an ability of these agents to release neurosteroids locally. |
10.1523/jneurosci.23-03-00788.2003 | 95,443,287 | In this study, we investigate how neurosteroid sensitivity of GABA A receptors (GABA A Rs) is regulated. We examined this issue in neurons of the supraoptic nucleus (SON) of the rat and found that, during parturition, the GABA A Rs become insensitive to the neurosteroid allopregnanolone attributable to a shift in the b... | 10.1038/nrn1703 | This study provides clear evidence that neurosteroid modulation of synaptic GABA A receptors can be dynamically regulated by the activity of resident kinases and phosphatases. This mechanism is implicated in the control of the timed release of oxytocin during parturition. |
10.1073/pnas.2435457100 | 104,308,890 | Neuroactive steroids are potent modulators of γ-aminobutyric acid type A receptors (GABA A Rs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo , neuroactive steroids specifically enhance a tonic inhibi... | 10.1038/nrn1703 | This study describes the selective neurosteroid enhancement in DGCs and CGCs of the 'tonic current' mediated by δ-subunit-containing extrasynaptic GABA A receptors. These extrasynaptic receptors can greatly influence neuronal excitability and might, therefore, be an important locus of neurosteroid action. |
10.1523/jneurosci.23-31-10013.2003 | 10,248,436 | Neurosteroids typified by 5α-pregnan-3α-ol-20-one (5α3α) have emerged as the most potent endogenous positive modulators of the GABA A receptor, the principal mediator of fast inhibitory transmission within the CNS. Neurosteroids can be synthesized de novo in the brain in levels sufficient to modulate GABA A receptor fu... | 10.1038/nrn1703 | This paper reports that inhibitors of 3α-HSD, including the widely prescribed contraceptive methoxyprogesterone acetate (Provera), enhance synaptic and extrasynaptic GABA A -receptor-mediated responses, which indicate the presence of a background 'neurosteroid tone'. |
10.1146/annurev.pharmtox.44.101802.121429 | 41,746,359 | GABA A receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension, epileptogenic activity, and memory functions, and the enhancement of GABA A receptor-mediated fast synaptic inhibition is the basis for the pharmacotherapy of various neurological and psychiatric disorders. Two kinds of ... | 10.1038/nrn1703 | A review of how transgenic 'knock-in' mice are being used to determine which GABA A receptor isoforms mediate the behavioural actions of benzodiazepines and certain general anaesthetics. |
10.1073/pnas.95.8.4425 | 81,504,273 | We have analyzed DNA sequences from world-wide geographic strains of Plasmodium falciparum and found a complete absence of synonymous DNA polymorphism at 10 gene loci. We hypothesize that all extant world populations of the parasite have recently derived (within several thousand years) from a single ancestral strain. T... | 10.1038/nrmicro795 | A key paper and important stimulus to research on the population genetics of P. falciparum , which concluded from an analysis of GenBank sequences that the present parasite population derives relatively recently from a relatively small number of common ancestors. |
10.1126/science.1075642 | 1,331,093 | The detection of single-nucleotide polymorphisms in pathogenic microorganisms has normally been carried out by trial and error. Here we show that DNA hybridization with high-density oligonucleotide arrays provides rapid and convenient detection of single-nucleotide polymorphisms in Plasmodium falciparum , despite its e... | 10.1038/nrmicro795 | This paper describes the unusual distribution of single-nucleotide polymorphisms in chromosome 2 of P. falciparum , with most polymorphisms concentrated in the subtelomeric regions and with a disproportionate number present in genes encoding proteins associated with the cell membrane. |
10.1126/science.1081449 | 41,724,248 | The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, ... | 10.1038/nrmicro795 | A study of mitochondrial DNA sequences indicating that rapid population growth of a relatively small number of lineages of P. falciparum started about 10,000 years ago. |
10.1152/jn.00571.2004 | 100,782,267 | The tilt aftereffect (TAE) is a visual illusion in which prolonged adaptation to an oriented stimulus causes shifts in subsequent perceived orientations. Historically, neural models of the TAE have explained it as the outcome of response suppression of neurons tuned to the adapting orientation. Recent physiological stu... | 10.1038/nrn2155 | Demonstrates how changes in tuning curves observed in cortical adaptation data can give rise to perceptual repulsion and attraction within a population decoding model. |
10.1152/jn.00970.2002 | 81,708,665 | Learning and adaptation in the domain of orientation processing are among the most studied topics in the literature. However, little effort has been devoted to explaining the diverse array of experimental findings via a physiologically based model. We have started to address this issue in the framework of the recurrent... | 10.1038/nrn2155 | Proposes a mechanistic population decoding model and draws out the perceptual implications for two different timescales of temporal context, namely adaptation and learning. |
10.1073/pnas.0409311102 | 16,726,315 | Visual stimuli that entail the intersection of two or more straight lines elicit a variety of well known perceptual anomalies. Preeminent among these anomalies are the systematic overestimation of acute angles, the underestimation of obtuse angles, and the misperceptions of line orientation exemplified in the classical... | 10.1038/nrn2155 | Measures image statistics of overlapping orientations in space, and suggests how these can give rise to perceptual tilt illusions. |
10.1126/science.287.5456.1273 | 83,296,136 | Theoretical studies suggest that primary visual cortex (area V1) uses a sparse code to efficiently represent natural scenes. This issue was investigated by recording from V1 neurons in awake behaving macaques during both free viewing of natural scenes and conditions simulating natural vision. Stimulation of the nonclas... | 10.1038/nrn2155 | Suggests that spatial context increases the efficiency of cortical neural processing. |
10.7551/mitpress/7503.001.0001 | 80,101,123 | Papers from the 2006 flagship meeting on neural computation, with contributions from physicists, neuroscientists, mathematicians, statisticians, and computer scientists. The annual Neural Information Processing Systems (NIPS) conference is the flagship meeting on neural computation and machine learning. It draws a dive... | 10.1038/nrn2155 | Proposes a Bayesian model of visual adaption in terms of adjustments to the likelyhood, on the important basis that changes to the prior are likely to lead to perceptual attraction rather than repulsion. |
10.1073/pnas.1105855108 | 35,989,449 | The ability to derive meaning from complex sensory input requires the integration of information over space and time, as well as cognitive mechanisms to shape that integration. We studied these processes in the primary visual cortex (V1), where neurons are thought to integrate visual inputs along contours defined by an... | 10.1038/nrn3476 | Neurons in area V1 are selective for more complex geometric shapes than previously thought, and their shape-selectivity is dependent on the shape the animal is cued to expect. This reflects the ability of neurons to selectively express subcomponents of their association fields. |
10.1152/jn.1996.76.5.2841 | 84,559,635 | 1. Posterior parietal cortex contains neurons that are visually responsive and active in relation to saccadic eye movements. We recorded from single neurons in a subregion of parietal cortex, the lateral intraparietal area (LIP), in alert rhesus monkeys. To characterize more completely the circumstances under which LIP... | 10.1038/nrn3476 | Receptive fields shift in anticipation of eye movements, which may underlie the perceived stability of visual targets across eye movements. |
10.1162/089976699300016827 | 45,560,682 | We study the impact of correlated neuronal firing rate variability on the accuracy with which an encoded quantity can be extracted from a population of neurons. Contrary to widespread belief, correlations in the variabilities of neuronal firing rates do not, in general, limit the increase in coding accuracy provided by... | 10.1038/nrn3476 | This study provides a theoretical framework for understanding the conditions under which changes in the structure of correlated activity over a neuronal population can increase the amount of information carried by the population. |
10.1126/science.1171402 | 82,969,531 | Attention and Synchrony Neural activity in the visual cortex becomes synchronized with attention and other behavioral states. However, the source of this synchrony is still unknown. Gregoriou et al. (p. 1207 ) tested the hypothesis that synchronized activity from the frontal eye field is one of the causes of the synchr... | 10.1038/nrn3476 | Attention affects long-range coupling between cortical areas. Also see reference 69. |
10.1523/jneurosci.2883-07.2007 | 123,179,972 | New gene expression is necessary for long-term potentiation (LTP) consolidation, yet roles for specific activity-induced mRNAs have not been defined. Here we probed the dynamic function of activity-induced Arc (activity-regulated cytoskeletal-associated protein)/Arg3.1 (activity-regulated gene 3.1 protein homolog) mRNA... | 10.1038/nrn2150 | This paper couples dendritic Arc synthesis to local stabilization of F-actin and LTP consolidation. |
10.1126/science.1096202 | 61,039,988 | We examined dendritic protein synthesis after a prolonged blockade of action potentials alone and after a blockade of both action potentials and miniature excitatory synaptic events (minis). Relative to controls, dendrites exposed to a prolonged blockade of action potentials showed diminished protein synthesis. Dendrit... | 10.1038/nrn2150 | This study demonstrates tonic inhibition of dendritic protein synthesis in response to spontaneous glutamate release. |
10.1073/pnas.122205699 | 62,615,302 | Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical evidence indicates that FMRP binds a subset of mRNAs and acts as a regulator of translation. However, the consequences of FMRP... | 10.1038/nrn2150 | This study shows that there is an increase in the amplitude of LTD in mice that lack FMRP protein. It was the basis for the mGluR theory of fragile-X syndrome. |
10.1126/science.288.5469.1254 | 38,241,381 | A hippocampal pyramidal neuron receives more than 10 4 excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic p... | 10.1038/nrn2150 | This paper provides the best evidence to date that dendritic protein synthesis is crucial for some forms of synaptic plasticity. |
10.1152/jn.1986.56.3.640 | 62,581,894 | Convergence of inputs from different sensory modalities onto individual neurons is a phenomenon that occurs widely throughout the brain at many phyletic levels and appears to represent a basic neural mechanism by which an organism integrates complex environmental stimuli. In the present study, neurons in the superior c... | 10.1038/nrn3503 | This paper is among the first to demonstrate the impressive capacity of SC neurons to combine visual, tactile and auditory cues, yielding multisensory responses that were often considerably enhanced (and sometimes suppressed) relative to unisensory responses. These early observations laid the foundation for the well-kn... |
10.1523/jneurosci.5095-04.2005 | 45,559,562 | It is well established that superior colliculus (SC) multisensory neurons integrate cues from different senses; however, the mechanisms responsible for producing multisensory responses are poorly understood. Previous studies have shown that spatially congruent cues from different modalities (e.g., auditory and visual) ... | 10.1038/nrn3503 | This study explores multisensory interactions in the SC in a more systematic manner than previous work by varying the intensity and timing of visual and auditory stimuli. The results suggest that most SC neurons combine their inputs additively and that the oft-cited phenomenon of 'superadditivity' may only occur for ve... |
10.1042/bj20021528 | 62,495,104 | The physiological role of ceramide formation in response to cell stimulation remains controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling molecule. Recent work points out that the conversion of sphingomyelin into ceramide can play a membrane structural (physical) role, with consequenc... | 10.1038/nrn1608 | This useful review discusses physical properties of ceramide that relate to its role in regulating lipid structure and curvature, raft formation and regulatory function, and vesicle formation and trafficking. |
10.1046/j.1471-4159.2003.01258.x | 108,932,669 | Abstract Synaptophysin interacts with synaptobrevin in membranes of adult small synaptic vesicles. The synaptophysin/synaptobrevin complex promotes synaptobrevin to built up functional SNARE complexes thereby modulating synaptic efficiency. Synaptophysin in addition is a cholesterol‐binding protein. Depleting the membr... | 10.1038/nrn1608 | Synaptophysin is a cholesterol-binding protein that forms a complex with the SNARE protein synaptobrevin. Pharmacological and genetic cholesterol perturbation reduced synaptophysin–synaptobrevin complex formation in non-neuronal cells as well as in hippocampal neurons, indicating that concentrated vesicle cholesterol l... |
10.1073/pnas.091502398 | 100,815,454 | Lipid rafts are microdomains present within membranes of most cell types. These membrane microdomains, which are enriched in cholesterol and glycosphingolipids, have been implicated in the regulation of certain signal transduction and membrane traffic pathways. To investigate the possibility that lipid rafts organize e... | 10.1038/nrn1608 | In PC12 neurosecretory cells, the plasma membrane SNAREs are concentrated in detergent-insoluble lipid raft membranes, whereas the vesicular SNARE synaptobrevin is concentrated in a rafts of different composition, indicating that raft–SNARE interactions are important for regulated vesicle fusion. |
10.1073/pnas.0308693100 | 86,945,989 | Transgenic expression of ceramidase suppresses retinal degeneration in Drosophila arrestin and phospholipase C mutants. Here, we show that expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE I17 mutants lacking the G protein ... | 10.1038/nrn1608 | The second of two important studies from this group showing that retinal ceramidase (SLAB) overexpression correspondingly reduced ceramide concentrations and facilitated membrane and protein recycling, which showed that the sphinolipid pathway mediated modulation of endocytosis. |
10.1083/jcb.200107075 | 102,691,234 | Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin. Perturbation of endophilin function in cell-free systems and in a living synapse has implicated endophilin in endocytic vesicle budding (Ringstad, N., H. Gad, P. Low, G. Di Paolo, L. B... | 10.1038/nrn1608 | An important study showing that purified endophilin is able to bind to, and generate curved membrane structures with similar geometry to budding synaptic vesicles. Endophilin's lipid restructuring activity is independent of a catalytic/enzymatic activity and is mediated by an NH2-terminal region BAR domain common to am... |
10.4049/jimmunol.167.6.3029 | 123,444,450 | Abstract Abs are the major effectors of host defense against infections with Borrelia. Bactericidal murine mAbs and their Fabs destroy B. burgdorferi, the agent of Lyme disease, and relapsing fever Borrelia in the absence of complement. These in vitro observations led to the expansion of a search for functionally simil... | 10.1038/nrmicro974 | Reports that certain antibodies can kill bacteria directly by altering their surface structures. |
10.1073/pnas.1731272100 | 28,112,705 | There is an urgent need for new antimicrobial therapies to combat drug resistance, new pathogens, and the relative inefficacy of current therapy in compromised hosts. Ionizing radiation can kill microorganisms quickly and efficiently, but this modality has not been exploited as a therapeutic antimicrobial strategy. We ... | 10.1038/nrmicro974 | Showed that labelling antibodies with radionuclides converts them into microbicidal molecules that can be used in therapy of fungal infections. |
10.1126/science.1077642 | 103,181,758 | Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H 2 O 2 ) from singlet molecular oxygen ( 1 O 2 *) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H 2 O 2 production by antibodies alone was fou... | 10.1038/nrmicro974 | Showed that antibodies can catalyse the formation of oxygen-derived oxidants, which might contribute to their antimicrobial properties. |
10.1073/pnas.0400146101 | 103,216,188 | Little is known about the mutational fitness effects associated with single-nucleotide substitutions on RNA viral genomes. Here, we used site-directed mutagenesis to create 91 single mutant clones of vesicular stomatitis virus derived from a common ancestral cDNA and performed competition experiments to measure the rel... | 10.1038/nrmicro3003 | The first study to rigorously examine mutational fitness effects in an RNA virus and demonstrate that the vast majority of mutations are detrimental to replicative fitness. |
10.1098/rspb.2007.1137 | 124,593,284 | Understanding the relationship between robustness and evolvability is key to understand how living things can withstand mutations, while producing ample variation that leads to evolutionary innovations. Mutational robustness and evolvability, a system's ability to produce heritable variation, harbour a paradoxical tens... | 10.1038/nrmicro3003 | An examination of the relationship between robustness and evolvability through analyses of RNA structures. |
10.1126/science.285.5427.578 | 104,415,657 | Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a ... | 10.1038/nrmicro927 | A clever approach to cloning a key adhesin gene from Candida glabrata . The paper demonstrates the advantage of assessing the functions of Candida adhesin genes in Saccharomyces cerevisiae |
10.1099/mic.0.26495-0 | 18,863,341 | The ALS gene family of Candida albicans consists of eight genes ( ALS1 to ALS7 and ALS9 ) that encode cell-wall glycoproteins involved in adhesion to host surfaces. Considerable allelic sequence variability has been documented for regions of ALS genes encoding repeated sequences. Although regions of ALS genes encoding ... | 10.1038/nrmicro927 | Shows that three of the Candida albicans adhesins are linked on chromosome 6 and that the two alleles for each gene have different numbers of repeats. |
10.1126/science.283.5407.1535 | 19,106,204 | The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans . Morphology-specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve ... | 10.1038/nrmicro927 | Describes a unique mechanism by which a Candida cell-wall protein might become linked to the surface of human cells. |
10.1093/genetics/158.1.155 | 83,372,767 | Abstract The instability of simple tandem repeats, such as human minisatellite loci, has been suggested to arise by gene conversions. In Saccharomyces cerevisiae, a double-strand break (DSB) was created by the HO endonuclease so that DNA polymerases associated with gap repair must traverse an artificial minisatellite o... | 10.1038/nrmicro927 | An excellent analysis of specific mechanisms by which the number of repeats can be amplified or reduced. |
10.1111/j.1462-2920.2004.00655.x | 124,730,165 | Summary Engineering bacteria for measuring chemicals of environmental or toxicological concern (bioreporter bacteria) has grown slowly into a mature research area. Despite many potential advantages, current bioreporters do not perform well enough to comply with environmental detection standards. Basically, the reasons ... | 10.1038/nrmicro2392 | This article takes a detailed look at the chain of events occurring during target detection in bacterial bioreporters. |
10.1073/pnas.041620498 | 38,657,018 | Gene expression profiling provides powerful analyses of transcriptional responses to cellular perturbation. In contrast to DNA array-based methods, reporter gene technology has been underused for this application. Here we describe a genomewide, genome-registered collection of Escherichia coli bioluminescent reporter ge... | 10.1038/nrmicro2392 | The first genome-wide search using reporter fusion libraries to find stress-responsive promoters. |
10.1111/j.1751-7915.2007.00011.x | 124,750,984 | Summary Bioassays with bioreporter bacteria are usually calibrated with analyte solutions of known concentrations that are analysed along with the samples of interest. This is done as bioreporter output (the intensity of light, fluorescence or colour) does not only depend on the target concentration, but also on the in... | 10.1038/nrmicro2392 | Some interesting concepts for producing stepwise concentration range-dependent responses from arsenic bioreporters. |
10.1111/j.1365-2958.2007.05832.x | 124,743,089 | Summary Evolutionary expansion of metabolic networks entails the emergence of regulatory factors that become sensitive to new chemical species. A dedicated genetic system was developed for the soil bacterium Pseudomonas putida aimed at deciphering the steps involved in the gain of responsiveness of the toluene‐activate... | 10.1038/nrmicro2392 | A fascinating introduction to the concept of shaping bacterial catabolic regulatory proteins to accommodate new effector proteins. |
10.1111/j.1462-2920.2008.01722.x | 124,748,281 | Summary A broad host range, orthogonal genetic platform has been developed to format sensor circuits in the chromosome of Gram‐negative microorganisms destined for environmental release as bioindicators of toxic or perilous compounds (e.g. explosives) in soil. The genetic scheme includes the generation of a genomic lan... | 10.1038/nrmicro2392 | An excellent example of the power of scarless cloning of bioreporter circuits. |
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