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PMC9588873 | core_pubmed_pmc | Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study | Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study Abstract Background The anti-CD38 antibody isatuximab is approved for the treatment of relapsed/refractory multiple myeloma, but there are no data on its efficacy in solid tumors. This phase I/I... |
PMC8363704 | core_pubmed_pmc | Safety and Systemic Exposure of Triamcinolone Acetonide Following Ultrasound-Guided Intra-Articular Injection of Triamcinolone Extended-Release or Standard Triamcinolone Acetonide in Patients with Shoulder Osteoarthritis: An Open-Label, Randomized Study | Safety and Systemic Exposure of Triamcinolone Acetonide Following Ultrasound-Guided Intra-Articular Injection of Triamcinolone Extended-Release or Standard Triamcinolone Acetonide in Patients with Shoulder Osteoarthritis: An Open-Label, Randomized Study Abstract Abstract Background and Objectives Osteoarthritis (OA) is... |
PMC4539086 | core_pubmed_pmc | Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid | Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid Abstract Valproic acid (VPA) is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC) administration leads to decreased levels of β-glucuronidas... |
PMC10895697 | core_pubmed_pmc | Intracellular activity and in vivo efficacy in a mouse model of septic arthritis of the novel pseudopeptide Pep16 against Staphylococcus aureus clinical isolates | Intracellular activity and in vivo efficacy in a mouse model of septic arthritis of the novel pseudopeptide Pep16 against Staphylococcus aureus clinical isolates Abstract Abstract Objectives Assessing the therapeutic potential of a novel antimicrobial pseudopeptide, Pep16, both in vitro and in vivo for the treatment of... |
PMC12546074 | core_pubmed_pmc | Population pharmacokinetic modeling in radiopharmaceutical therapy: a review | Population pharmacokinetic modeling in radiopharmaceutical therapy: a review Abstract Population pharmacokinetic (PopPK) has emerged as a robust framework for characterizing inter-individual variability in the absorbed dose estimates in radiopharmaceutical therapy (RPT). By enabling the analysis of biokinetic data from... |
PMC8129720 | core_pubmed_pmc | Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2‐negative breast cancer patients treated with docetaxel | Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2‐negative breast cancer patients treated with docetaxel Abstract Abstract Information on individual lesion dynamics and organ location are often ignored in pharmacometric modeling analyses of tumor response. Typically, the ... |
PMC5066683 | core_pubmed_pmc | Dose‐Response Analysis of the Effect of Carbidopa‐Levodopa Extended‐Release Capsules (IPX066) in Levodopa‐Naive Patients With Parkinson Disease | Dose‐Response Analysis of the Effect of Carbidopa‐Levodopa Extended‐Release Capsules (IPX066) in Levodopa‐Naive Patients With Parkinson Disease Abstract Abstract Parkinson disease is an age‐related disorder of the central nervous system principally due to loss of dopamine‐producing cells in the midbrain. Levodopa, in c... |
PMC11825887 | core_pubmed_pmc | Comprehensive pharmacokinetic profiling and molecular docking analysis of natural bioactive compounds targeting oncogenic biomarkers in breast cancer | Comprehensive pharmacokinetic profiling and molecular docking analysis of natural bioactive compounds targeting oncogenic biomarkers in breast cancer Abstract Breast cancer is one of the leading causes of death in women worldwide, highlighting the crucial need for novel and effective treatments. In this study, we look ... |
PMC9823063 | core_pubmed_pmc | Veliparib with frontline chemotherapy and as maintenance in Japanese women with ovarian cancer: a subanalysis of efficacy, safety, and antiemetic use in the phase 3 VELIA trial | Veliparib with frontline chemotherapy and as maintenance in Japanese women with ovarian cancer: a subanalysis of efficacy, safety, and antiemetic use in the phase 3 VELIA trial Abstract Background The phase 3 VELIA trial evaluated veliparib with carboplatin/paclitaxel and as maintenance in patients with high-grade sero... |
PMC3728267 | core_pubmed_pmc | Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine | Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine Abstract Objective MAP0004 is an investigational product which delivers dihydroergotamine (DHE) through the lung via a breath-synchronized metered dose inhaler. ... |
PMC11649808 | core_pubmed_pmc | Impact of renal-adjusted ceftazidime/avibactam in patients with KPC-producing Klebsiella pneumoniae bloodstream infection: a retrospective cohort study | Impact of renal-adjusted ceftazidime/avibactam in patients with KPC-producing Klebsiella pneumoniae bloodstream infection: a retrospective cohort study Abstract Abstract Background Bloodstream infections (BSIs) caused by KPC-producing Klebsiella pneumoniae (KPC-Kp) are still associated with high mortality, and the game... |
PMC3501191 | core_pubmed_pmc | Review of intravenous immunoglobulin replacement therapy trials for primary humoral immunodeficiency patients | Review of intravenous immunoglobulin replacement therapy trials for primary humoral immunodeficiency patients Abstract Abstract An available supply of intravenous immunoglobulin (IVIG) is essential for individuals with primary humoral immunodeficiency. A shortage in 1997 prompted the Food and Drug Administration (FDA) ... |
PMC4034027 | core_pubmed_pmc | Safety, Tolerability, and Immunogenicity of Interferons | Safety, Tolerability, and Immunogenicity of Interferons Abstract Interferons (IFNs) are class II cytokines that are key components of the innate immune response to virus infection. Three IFN sub-families, type I, II, and III IFNs have been identified in man, Recombinant analogues of type I IFNs, in particular IFNα2 and... |
PMC4631805 | core_pubmed_pmc | Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy | Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy Abstract ABSTRACT Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis . Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhi... |
PMC5763318 | core_pubmed_pmc | Pharmacokinetics and Safety of Brexpiprazole Following Multiple‐Dose Administration to Japanese Patients With Schizophrenia | Pharmacokinetics and Safety of Brexpiprazole Following Multiple‐Dose Administration to Japanese Patients With Schizophrenia Abstract Abstract Brexpiprazole is currently approved in the United States for the treatment of schizophrenia and as adjunctive treatment of major depressive disorder. In Canada, it is approved fo... |
PMC10145105 | core_pubmed_pmc | Accuracy of Therapeutic Drug Monitoring of Teicoplanin at the Onset of Febrile Neutropenia | Accuracy of Therapeutic Drug Monitoring of Teicoplanin at the Onset of Febrile Neutropenia Abstract Background and Objectives : Teicoplanin (TEIC) is an effective drug for patients with febrile neutropenia (FN); however, it has been reported that these patients may have increased TEIC clearance compared with patients w... |
PMC7646457 | core_pubmed_pmc | Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink | Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink Abstract Abstract Optimizing antimicrobial dosage regimens and development of breakpoints for antimicrobial susceptibility testing are important prerequisites for rational ant... |
PMC10798785 | core_pubmed_pmc | Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis: A multicenter, randomized, double-blind, placebo-controlled phase 2b trial | Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis: A multicenter, randomized, double-blind, placebo-controlled phase 2b trial Abstract Abstract Background: Atopic dermatitis (AD) affects approximately 10% of adults worldwide. CM310 is a humanized monoclonal antibody targeting interleukin-4 receptor a... |
PMC12495087 | core_pubmed_pmc | BOS172738, a selective RET inhibitor, for the treatment of patients with RET -altered tumors including RET -fusion-positive non-small-cell lung cancer and RET -mutant medullary thyroid cancer: a phase I dose-escalation/expansion multicenter study | BOS172738, a selective RET inhibitor, for the treatment of patients with RET -altered tumors including RET -fusion-positive non-small-cell lung cancer and RET -mutant medullary thyroid cancer: a phase I dose-escalation/expansion multicenter study Abstract Abstract Background This phase I dose-escalation (part A)/dose-e... |
PMC5516194 | core_pubmed_pmc | Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects | Platelet Aggregation Inhibitory Effects and Pharmacokinetics of Prasugrel Used in Combination With Aspirin in Healthy Japanese Subjects Abstract Abstract We evaluated the pharmacokinetics and pharmacodynamics of prasugrel used in combination with aspirin in healthy Japanese subjects. All subjects received aspirin 100 m... |
PMC7149950 | core_pubmed_pmc | Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study | Bumetanide Therapeutic Effect in Children and Adolescents With Autism Spectrum Disorder: A Review Study Abstract Introduction: Autism Spectrum Disorder (ASD) is characterized by several impairments in communications and social interactions, as well as restricted interests or stereotyped behaviors. Interventions applied... |
PMC6339717 | core_pubmed_pmc | Mathematical Modeling for Pharmaco-Kinetic and -Dynamic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric Study | Mathematical Modeling for Pharmaco-Kinetic and -Dynamic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric Study Abstract Predicting pharmacokinetics, based on the theory of dynamic systems, for an administered drug (whether intravenously, orally, intramuscularly, etc.), is an industrial and... |
PMC3182160 | core_pubmed_pmc | First Phase 1 Double-Blind, Placebo-Controlled, Randomized Rectal Microbicide Trial Using UC781 Gel with a Novel Index of Ex Vivo Efficacy | First Phase 1 Double-Blind, Placebo-Controlled, Randomized Rectal Microbicide Trial Using UC781 Gel with a Novel Index of Ex Vivo Efficacy Abstract Objectives Successful control of the HIV/AIDS pandemic requires reduction of HIV-1 transmission at sexually-exposed mucosae. No prevention studies of the higher-risk rectal... |
PMC4386773 | core_pubmed_pmc | Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112 | Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112 Abstract Introduction SNX-2112 is a promising anticancer agent but has poor solubility in both water and oil. In the study reported here, we aimed to develop a nanocrystal fo... |
PMC12847666 | core_pubmed_pmc | Pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks using two injection volumes in adult cats | Pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks using two injection volumes in adult cats Abstract Objectives This study described the pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks in adult cats under general anaes... |
PMC10825620 | core_pubmed_pmc | Pharmacokinetics of dacarbazine and unesbulin and CYP1A2‐mediated drug interactions in patients with leiomyosarcoma | Pharmacokinetics of dacarbazine and unesbulin and CYP1A2‐mediated drug interactions in patients with leiomyosarcoma Abstract Abstract Unesbulin is being investigated in combination with dacarbazine (DTIC) as a potential therapeutic agent in patients with advanced leiomyosarcoma (LMS). This paper reports the pharmacokin... |
PMC4033217 | core_pubmed_pmc | Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies | Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies Abstract Abstract SLE is a complex autoimmune inflammatory disease characterized by pathogenic autoantibody production as a consequence of uncontrolled T–B cell activity and immune-complex deposition... |
PMC11802704 | core_pubmed_pmc | An Exploration of the Interplay Between Caffeine and Antidepressants Through the Lens of Pharmacokinetics and Pharmacodynamics | An Exploration of the Interplay Between Caffeine and Antidepressants Through the Lens of Pharmacokinetics and Pharmacodynamics Abstract Caffeine consumption is regarded as a widespread phenomenon, and its usage has continued to increase. In addition, the growing usage of antidepressants worldwide and increase in mental... |
PMC11199264 | core_pubmed_pmc | Systematic Evaluation of Osimertinib Population Pharmacokinetic Models in a Cohort of Dutch Adults with Non-Small Cell Lung Cancer | Systematic Evaluation of Osimertinib Population Pharmacokinetic Models in a Cohort of Dutch Adults with Non-Small Cell Lung Cancer Abstract Background and Objective Several population pharmacokinetic (popPK) studies have been reported that can guide the prediction of osimertinib plasma concentrations in individual pati... |
PMC12613104 | core_pubmed_pmc | Marstacimab, an antitissue factor pathway inhibitor, combined with bypassing agents: effects on thrombin generation and in hemostatically normal rats | Marstacimab, an antitissue factor pathway inhibitor, combined with bypassing agents: effects on thrombin generation and in hemostatically normal rats Abstract Abstract Background Marstacimab is an antitissue factor pathway inhibitor recently approved for treatment of hemophilia without inhibitors and under investigatio... |
PMC9810433 | core_pubmed_pmc | Sequential antibiotic therapy in the laboratory and in the patient | Sequential antibiotic therapy in the laboratory and in the patient Abstract Abstract Laboratory experiments suggest that rapid cycling of antibiotics during the course of treatment could successfully counter resistance evolution. Drugs involving collateral sensitivity could be particularly suitable for such therapies. ... |
PMC6811611 | core_pubmed_pmc | Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs | Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs Abstract Ceftiofur (CEF) sodium is a third-generation broad-spectrum cephalosporin commonly used in an extra-label manner in dogs for the treatment of respiratory and urinary system infections. To contribute to the litera... |
PMC5192392 | core_pubmed_pmc | Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses | Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses Abstract Abstract Griffithsin (GRFT) is a red alga-derived lectin with demonstrated broad spectrum antiviral activity against enveloped viruses, including severe acute respiratory syndrome–Coronavirus... |
PMC2880602 | core_pubmed_pmc | Plasma Concentrations of Oseltamivir and Oseltamivir Carboxylate in Critically Ill Children on Extracorporeal Membrane Oxygenation Support | Plasma Concentrations of Oseltamivir and Oseltamivir Carboxylate in Critically Ill Children on Extracorporeal Membrane Oxygenation Support Abstract Introduction To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children. M... |
PMC11015082 | core_pubmed_pmc | Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling | Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling Abstract Abstract Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may ... |
PMC7551818 | core_pubmed_pmc | Virtual Screening of Marine Natural Compounds by Means of Chemoinformatics and CDFT-Based Computational Peptidology | Virtual Screening of Marine Natural Compounds by Means of Chemoinformatics and CDFT-Based Computational Peptidology Abstract Abstract This work presents the results of a computational study of the chemical reactivity and bioactivity properties of the members of the theopapuamides A-D family of marine peptides by making... |
PMC7160087 | core_pubmed_pmc | Pharmacokinetics and safety of bilastine in children aged 6 to 11 years with allergic rhinoconjunctivitis or chronic urticaria | Pharmacokinetics and safety of bilastine in children aged 6 to 11 years with allergic rhinoconjunctivitis or chronic urticaria Abstract Abstract Bilastine, a second-generation antihistamine, is approved in Europe for the treatment of allergic rhinoconjunctivitis and urticaria in adults and children aged ≥ 6 years. Phar... |
PMC11946918 | core_pubmed_pmc | Low‐Density Lipoprotein Cholesterol Increases Significantly During Brief Discontinuation of Atorvastatin and Correlates With Metabolite Half‐Lives | Low‐Density Lipoprotein Cholesterol Increases Significantly During Brief Discontinuation of Atorvastatin and Correlates With Metabolite Half‐Lives Abstract ABSTRACT Variability in low‐density lipoprotein cholesterol (LDL‐C) has emerged as a potential independent cardiovascular risk factor, but the impact of short‐term ... |
PMC12706427 | core_pubmed_pmc | Redefining Parameter Estimation and Covariate Selection via Variational Autoencoders: One Run Is All You Need | Redefining Parameter Estimation and Covariate Selection via Variational Autoencoders: One Run Is All You Need Abstract ABSTRACT Generative Artificial Intelligence (AI) frameworks, such as Variational Autoencoders (VAEs), have proven powerful in learning structured representations from complex, high‐dimensional data. In... |
PMC3796665 | core_pubmed_pmc | Plasma pharmacokinetics and urinary excretion of isoflavones after ingestion of soy products with different aglycone/glucoside ratios in South Korean women | Plasma pharmacokinetics and urinary excretion of isoflavones after ingestion of soy products with different aglycone/glucoside ratios in South Korean women Abstract Asian populations are thought to receive significant health benefits from traditional diets rich in soybeans due to high isoflavone contents. However, avai... |
PMC5209880 | core_pubmed_pmc | Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial | Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers—results of a dose escalation trial Abstract Background Certain disadvantages of the standard hematopoietic stem and progenitor cell (HSPC) mobilizing agent G-CSF fuel the quest for alternatives. We her... |
PMC3790171 | core_pubmed_pmc | Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030) | Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030) Abstract Background: The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on th... |
PMC8520748 | core_pubmed_pmc | Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires | Population repeated time‐to‐event analysis of exacerbations in asthma patients: A novel approach for predicting asthma exacerbations based on biomarkers, spirometry, and diaries/questionnaires Abstract Abstract Identification of covariates, including biomarkers, spirometry, and diaries/questionnaires, that predict asth... |
PMC5498193 | core_pubmed_pmc | A Prospective Study of the Efficacy, Safety and Pharmacokinetics of Enteral Moxifloxacin in the Treatment of Hemodialysis Patients with Pneumonia | A Prospective Study of the Efficacy, Safety and Pharmacokinetics of Enteral Moxifloxacin in the Treatment of Hemodialysis Patients with Pneumonia Abstract Abstract Objectives To investigate the efficacy of oral moxifloxacin (MFLX) as a treatment for pneumonia in hemodialysis (HD) patients and the pharmacokinetic (PK) p... |
PMC5492117 | core_pubmed_pmc | Thrombocytopenia induced by dabigatran: two case reports | Thrombocytopenia induced by dabigatran: two case reports Abstract Background Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These agents have been mainstays of anti... |
PMC10056847 | core_pubmed_pmc | Optimization of Therapy and the Risk of Probiotic Use during Antibiotherapy in Septic Critically Ill Patients: A Narrative Review | Optimization of Therapy and the Risk of Probiotic Use during Antibiotherapy in Septic Critically Ill Patients: A Narrative Review Abstract Abstract Optimizing the entire therapeutic regimen in septic critically ill patients should be based not only on improving antibiotic use but also on optimizing the entire therapeut... |
PMC12587387 | core_pubmed_pmc | Nonclinical and Clinical Assessments of an Optimized Tablet Formulation of the Novel HER2-Selective Tyrosine Kinase Inhibitor Zongertinib: Focus on Relative Bioavailability and Impact of Variation of Gastric pH | Nonclinical and Clinical Assessments of an Optimized Tablet Formulation of the Novel HER2-Selective Tyrosine Kinase Inhibitor Zongertinib: Focus on Relative Bioavailability and Impact of Variation of Gastric pH Abstract Abstract Zongertinib (BI 1810631), a novel orally administered HER2-specific tyrosine kinase inhibit... |
PMC7335720 | core_pubmed_pmc | Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability | Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability Abstract Abstract Herein, we report novel macromolecular prodrugs (MPDs) of flurbiprofen (FLB) onto a cellulose ether, hydroxypropylcellulose (HPC). The FLB was activated with a powerful acy... |
PMC8689075 | core_pubmed_pmc | Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation | Population Pharmacokinetic Model Development of Tacrolimus in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplantation Abstract Background: With a notably narrow therapeutic window and wide intra- and interindividual pharmacokinetic (PK) variability, initial weight-based dosing along with routin... |
PMC6363066 | core_pubmed_pmc | Reducing Palivizumab Dose Requirements Through Rational Dose Regimen Design | Reducing Palivizumab Dose Requirements Through Rational Dose Regimen Design Abstract Abstract Palivizumab for respiratory syncytial virus (RSV) immunoprophylaxis in premature infants poses a significant economic challenge. Although standard dosing of palivizumab results in unnecessary drug accumulation without addition... |
PMC5192973 | core_pubmed_pmc | Population Pharmacokinetics of Bedaquiline and Metabolite M2 in Patients With Drug‐Resistant Tuberculosis: The Effect of Time‐Varying Weight and Albumin | Population Pharmacokinetics of Bedaquiline and Metabolite M2 in Patients With Drug‐Resistant Tuberculosis: The Effect of Time‐Varying Weight and Albumin Abstract Abstract Albumin concentration and body weight are altered in patients with multidrug‐resistant tuberculosis (MDR‐TB) and change during the long treatment per... |
PMC10305499 | core_pubmed_pmc | A Chemically Defined TLR3 Agonist with Anticancer Activity | A Chemically Defined TLR3 Agonist with Anticancer Activity Abstract ABSTRACT Toll-like receptor 3 (TLR3) agonists such as polyinosinic:polycytidylic acid (poly(I:C)) have immunostimulatory effects that can be taken advantage of to induce anticancer immune responses in preclinical models. In addition, poly(I:C) has been... |
PMC9893467 | core_pubmed_pmc | Cyclohexane-1,3-dione Derivatives as Future Therapeutic Agents for NSCLC: QSAR Modeling, In Silico ADME-Tox Properties, and Structure-Based Drug Designing Approach | Cyclohexane-1,3-dione Derivatives as Future Therapeutic Agents for NSCLC: QSAR Modeling, In Silico ADME-Tox Properties, and Structure-Based Drug Designing Approach Abstract The abnormal expression of the c-Met tyrosine kinase has been linked to the proliferation of several human cancer cell lines, including non-small-c... |
PMC3857674 | core_pubmed_pmc | Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons | Statistical strategies for constructing health risk models with multiple pollutants and their interactions: possible choices and comparisons Abstract Background As public awareness of consequences of environmental exposures has grown, estimating the adverse health effects due to simultaneous exposure to multiple pollut... |
PMC4702112 | core_pubmed_pmc | SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System | SPECT/NIRF Dual Modality Imaging for Detection of Intraperitoneal Colon Tumor with an Avidin/Biotin Pretargeting System Abstract We describe herein dual-modality imaging of intraperitoneal colon tumor using an avidin/biotin pretargeting system. A novel dual-modality probe, 99m Tc-HYNIC-lys(Cy5.5)-PEG 4 -biotin, was des... |
PMC10092881 | core_pubmed_pmc | Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats | Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats Abstract Abstract This study aimed to assess the single‐dose pharmacokinetics and tolerability of a cannabidiol (CBD) isolate in sunflower oil with escalating oral doses in eight healthy, purpose‐bred cats. Eight cats were randomized into ... |
PMC11375944 | core_pubmed_pmc | Hemoglobin and total bilirubin may affect tacrolimus clearance in liver transplant patient following the early postoperative period: a case report | Hemoglobin and total bilirubin may affect tacrolimus clearance in liver transplant patient following the early postoperative period: a case report Abstract Background Tacrolimus is a potent calcineurin inhibitor (CNI) that is principally used as a first-line immunosuppressant for the prophylaxis of allograft rejection ... |
PMC9841294 | core_pubmed_pmc | Reversal of rocuronium‐induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis | Reversal of rocuronium‐induced intense neuromuscular blockade by sugammadex in Korean children: A pharmacokinetic and pharmacodynamic analysis Abstract Abstract Sugammadex, a selective antagonist of steroidal non‐depolarizing neuromuscular blocking agents, has been used in children in limited circumstances. However, ne... |
PMC10515067 | core_pubmed_pmc | Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study | Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study Abstract Abstract Background COVID-19 is a respiratory illness caused by SARS-CoV-2. Pharmaceutical companies aim to control virus spread through effective drugs. This study investigat... |
PMC6989254 | core_pubmed_pmc | Development of a user-friendly training software for pharmacokinetic concepts and models | Development of a user-friendly training software for pharmacokinetic concepts and models Abstract Abstract Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics e... |
PMC11773096 | core_pubmed_pmc | Concentration‐QTc analysis of soticlestat in healthy adults: An alternative to a thorough QT study | Concentration‐QTc analysis of soticlestat in healthy adults: An alternative to a thorough QT study Abstract Abstract Aim This study aimed to examine the cardiac and overall safety and pharmacokinetic (PK) profiles of soticlestat (TAK‐935), an oral, first‐in‐class selective cholesterol 24‐hydroxylase inhibitor. Methods ... |
PMC9867083 | core_pubmed_pmc | Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model—An Isobolographic Transformation | Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model—An Isobolographic Transformation Abstract Abstract Numerous botanical drugs containing coumarins and terpenes are used in ethnomedicine all over the world for their var... |
PMC7677101 | core_pubmed_pmc | Antimicrobial Stewardship in the Intensive Care Unit: The Role of Biomarkers, Pharmacokinetics, and Pharmacodynamics | Antimicrobial Stewardship in the Intensive Care Unit: The Role of Biomarkers, Pharmacokinetics, and Pharmacodynamics Abstract Abstract The high prevalence of infectious diseases in the intensive care unit (ICU) and consequently elevated pressure for immediate and effective treatment have led to increased antimicrobial ... |
PMC8910571 | core_pubmed_pmc | In Vivo Evaluation of Sgc8-c Aptamer as a Molecular Imaging Probe for Colon Cancer in a Mouse Xenograft Model | In Vivo Evaluation of Sgc8-c Aptamer as a Molecular Imaging Probe for Colon Cancer in a Mouse Xenograft Model Abstract Abstract Recent biotechnological applications in the field of clinical oncology led to the identification of new biomarkers as molecular targets of cancer, and to broad developments in the field of per... |
PMC11840845 | core_pubmed_pmc | Effect of a Supratherapeutic Dose of Omaveloxolone on the Corrected QT Interval in Healthy Participants: A Randomized, Double‐Blind, Placebo‐ and Active‐Controlled, Three‐Way Crossover Study | Effect of a Supratherapeutic Dose of Omaveloxolone on the Corrected QT Interval in Healthy Participants: A Randomized, Double‐Blind, Placebo‐ and Active‐Controlled, Three‐Way Crossover Study Abstract ABSTRACT Omaveloxolone is approved for the treatment of Friedreich ataxia (FA) in patients aged ≥ 16 years at a dose of ... |
PMC5984074 | core_pubmed_pmc | Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey ( Chlorocebus aethiops sabaeus ) | Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey ( Chlorocebus aethiops sabaeus ) Abstract Abstract Objective: In humans, the ontogeny of obesity throughout the life course and the genetics underlying it has been historically difficult to... |
PMC11090130 | core_pubmed_pmc | Open-label extension of a randomized trial investigating safety and efficacy of rhPTH(1–84) in hypoparathyroidism | Open-label extension of a randomized trial investigating safety and efficacy of rhPTH(1–84) in hypoparathyroidism Abstract Abstract Hypoparathyroidism (HypoPT) is a rare disease, often inadequately controlled by conventional treatment. PARALLAX was a mandatory post-marketing trial assessing pharmacokinetics and pharmac... |
PMC8795118 | core_pubmed_pmc | Bioinformatics approaches identified dasatinib and bortezomib inhibit the activity of MCM7 protein as a potential treatment against human cancer | Bioinformatics approaches identified dasatinib and bortezomib inhibit the activity of MCM7 protein as a potential treatment against human cancer Abstract Abstract Minichromosome Maintenance Complex Component 7 (MCM7) is a key component of the DNA replication licensing factor and hexamer MCM (MCM2–7) complex that regula... |
PMC11390838 | core_pubmed_pmc | Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract | Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract Abstract Abstract Purpose Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign pa... |
PMC10989026 | core_pubmed_pmc | Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents | Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents Abstract ABSTRACT Existing pharmacodynamic (PD) mathematical models for drug combinations discriminate antagonistic, additive, multiplicative, and synergistic effects, but fail to consider how co... |
PMC9784645 | core_pubmed_pmc | Exploring the Effective Components and Mechanism of Action of Japanese Ardisia in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Experimental Verification | Exploring the Effective Components and Mechanism of Action of Japanese Ardisia in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Experimental Verification Abstract Abstract Japanese Ardisia is widely used as a hepatoprotective and anti-inflammatory agent in China. However, the active ingredient... |
PMC12471305 | core_pubmed_pmc | Diagnostic and Therapeutic Particularities of Sepsis in Hemodialysis Patients | Diagnostic and Therapeutic Particularities of Sepsis in Hemodialysis Patients Abstract Abstract Background: Sepsis is a leading cause of morbidity and mortality among patients receiving maintenance hemodialysis (HD), reflecting a unique combination of immunologic dysfunction, comorbidities, and healthcare-related expos... |
PMC7946912 | core_pubmed_pmc | A machine learning approach to personalized dose adjustment of lamotrigine using noninvasive clinical parameters | A machine learning approach to personalized dose adjustment of lamotrigine using noninvasive clinical parameters Abstract The pharmacokinetic variability of lamotrigine (LTG) plays a significant role in its dosing requirements. Our goal here was to use noninvasive clinical parameters to predict the dose-adjusted concen... |
PMC12185918 | core_pubmed_pmc | Brivaracetam: Pharmacology, Clinical Efficacy, and Safety in Epilepsy | Brivaracetam: Pharmacology, Clinical Efficacy, and Safety in Epilepsy Abstract Brivaracetam, a high-affinity synaptic vesicle 2A (SV2A) ligand and propyl analog of levetiracetam, has been approved as an adjunctive and monotherapy option for focal onset seizures in various age groups. This review synthesizes data from b... |
PMC10961402 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus | Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modeling of cetagliptin in patients with type 2 diabetes mellitus Abstract Abstract Aims To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with typ... |
PMC4295023 | core_pubmed_pmc | Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors | Phase 1 trial of tivantinib in combination with sorafenib in adult patients with advanced solid tumors Abstract Summary Purpose This phase I study evaluated the safety, tolerability, maximum tolerated dose (MTD), and recommended phase II dose (RP2D) of tivantinib combined with sorafenib in patients with advanced solid ... |
PMC3422234 | core_pubmed_pmc | Prediction of the Pharmacokinetic Parameters of Triptolide in Rats Based on Endogenous Molecules in Pre-Dose Baseline Serum | Prediction of the Pharmacokinetic Parameters of Triptolide in Rats Based on Endogenous Molecules in Pre-Dose Baseline Serum Abstract Abstract Background Individual variances usually affect drug metabolism and disposition, and hence result in either ineffectiveness or toxicity of a drug. In addition to genetic polymorph... |
PMC10524596 | core_pubmed_pmc | A physiologically based pharmacokinetic model for V937 oncolytic virus in mice | A physiologically based pharmacokinetic model for V937 oncolytic virus in mice Abstract Introduction: Oncolytic viruses (OVs) represent a novel therapeutic strategy in oncology due to their capability to selectively infect and replicate in cancer cells, triggering a direct and/or immune-induced tumor lysis. However, th... |
PMC8908370 | core_pubmed_pmc | Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study | Optimal Regimens and Clinical Breakpoint of Avilamycin Against Clostridium perfringens in Swine Based on PK-PD Study Abstract Abstract Clostridium perfringens causes significant morbidity and mortality in swine worldwide. Avilamycin showed no cross resistance and good activity for treatment of C. perfringens . The aim ... |
PMC8478725 | core_pubmed_pmc | Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease | Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease Abstract Abstract Introduction Despite strong evidence linking amyloid beta (Aβ) to Alzheimer's disease, most clinical trials have shown no clinical efficacy for reasons that remain unclear. To ... |
PMC10749172 | core_pubmed_pmc | Development of a Pharmacokinetic Model That Accounts for the Plasma Concentrations of Conjugated and Unconjugated Bilirubin Observed in a Variety of Disease States | Development of a Pharmacokinetic Model That Accounts for the Plasma Concentrations of Conjugated and Unconjugated Bilirubin Observed in a Variety of Disease States Abstract Introduction For a large variety of liver pathologies, the plasma unconjugated (UB) and conjugated (CB) bilirubin concentrations appear to be coupl... |
PMC9537296 | core_pubmed_pmc | A novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism | A novel glucagon analog with an extended half-life, HM15136, normalizes glucose levels in rodent models of congenital hyperinsulinism Abstract Abstract Congenital hyperinsulinism (CHI) is a rare genetic condition characterized by uncontrolled insulin secretion, resulting in hypoglycemia. Although glucagon has lately be... |
PMC4875962 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa | Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa Abstract Edoxaban, a once daily non-vitamin K antagonist oral anticoagulant, is a direct, selective, reversible inhibitor of factor Xa (FXa). In healthy subjects, single oral doses of edoxab... |
PMC12087607 | core_pubmed_pmc | Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals | Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals Abstract Introduction Liver fibrosis is a life-threatening disease that greatly impacts the morbidity and mortality of hepatic patients worldwide, resulting mainly as a cons... |
PMC7271226 | core_pubmed_pmc | Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects | Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects Abstract Abstract Resveratrol (RES) is a natural polyphenol with potential as an adjunctive therapeutic modality for periodontitis. However, its inferior pharmacokinetics and toxicity concerns about its commonly used solvent di... |
PMC12746527 | core_pubmed_pmc | Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology | Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology Abstract Abstract T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hemat... |
PMC6992657 | core_pubmed_pmc | Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge . and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method | Comparative Pharmacokinetics of Hydrophilic Components in Salvia miltiorrhiza Bge . and Carthamus tinctorius L. in Rats That Underwent Cerebral Ischemia Reperfusion Using an HPLC-DAD Method Abstract Abstract Background In China, the combination of herb Salvia miltiorrhiza Bge. (Danshen) and Carthamus tinctorius L . (Ho... |
PMC10515267 | core_pubmed_pmc | Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius , in poultry facilities | Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius , in poultry facilities Abstract Abstract Background Bed bug infestations are re-emerging in the poultry industry throughout the USA. Although the impacts of bed bugs on birds’ health and welfare are poorl... |
PMC10495004 | core_pubmed_pmc | Population pharmacokinetics of voriconazole and the role of CYP2C19 genotype on treatment optimization in pediatric patients | Population pharmacokinetics of voriconazole and the role of CYP2C19 genotype on treatment optimization in pediatric patients Abstract The aim of this study was to evaluate factors that impact on voriconazole (VRC) population pharmacokinetic (PPK) parameters and explore the optimal dosing regimen for different CYP2C19 g... |
PMC9630261 | core_pubmed_pmc | Programmable self-regulated molecular buffers for precise sustained drug delivery | Programmable self-regulated molecular buffers for precise sustained drug delivery Abstract Abstract Unlike artificial nanosystems, biological systems are ideally engineered to respond to their environment. As such, natural molecular buffers ensure precise and quantitative delivery of specific molecules through self-reg... |
PMC10653686 | core_pubmed_pmc | Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity | Toxicokinetics of a humanized anti-cocaine monoclonal antibody in male and female rats and lack of cross-reactivity Abstract ABSTRACT A humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disor... |
PMC6449573 | core_pubmed_pmc | Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae | Pharmacokinetics/pharmacodynamics of lefamulin in a neutropenic murine pneumonia model with Staphylococcus aureus and Streptococcus pneumoniae Abstract Abstract Objectives To present results of preclinical studies that supported further development of lefamulin for treating patients with community-acquired bacterial pn... |
PMC4818886 | core_pubmed_pmc | A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis: 54-week results from the PLANETRA study | A phase III randomized study to evaluate the efficacy and safety of CT-P13 compared with reference infliximab in patients with active rheumatoid arthritis: 54-week results from the PLANETRA study Abstract Background CT-P13 (Remsima®, Inflectra®) is a biosimilar of the infliximab reference product (RP; Remicade®). The a... |
PMC7236103 | core_pubmed_pmc | Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients: protocol for a randomised, multicentre, open-label, superiority clinical trial (BEATLE) | Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients: protocol for a randomised, multicentre, open-label, superiority clinical trial (BEATLE) Abstract Background Febrile neutropaenia (FN) is a very common complication in patients with haematological mal... |
PMC8306460 | core_pubmed_pmc | Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats | Comparative Pharmacokinetic Study of Forchlorfenuron in Adult and Juvenile Rats Abstract Abstract Forchlorfenuron (CPPU) is a plant growth regulator extensively used in agriculture. However, studies on CPPU pharmacokinetics are lacking. We established and validated a rapid, sensitive, and accurate liquid chromatography... |
PMC10969202 | core_pubmed_pmc | The REthinking Clinical Trials Program Retreat 2023: Creating Partnerships to Optimize Quality Cancer Care | The REthinking Clinical Trials Program Retreat 2023: Creating Partnerships to Optimize Quality Cancer Care Abstract Abstract Patients, families, healthcare providers and funders face multiple comparable treatment options without knowing which provides the best quality of care. As a step towards improving this, the REth... |
PMC12854766 | core_pubmed_pmc | Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration–Response Data | Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration–Response Data Abstract Abstract High-throughput screening (HTS) programs have generated abundant data on numerous chemicals, supporting the discovery of toxicity mechanisms and advancing understanding of adverse outcome pathways (... |
PMC11338045 | core_pubmed_pmc | Equivalence trial of proposed denosumab biosimilar GP2411 and reference denosumab in postmenopausal osteoporosis: the ROSALIA study | Equivalence trial of proposed denosumab biosimilar GP2411 and reference denosumab in postmenopausal osteoporosis: the ROSALIA study Abstract Abstract Denosumab is a monoclonal antibody used to reduce risk of fractures in osteoporosis. ROSALIA was a multicenter, double-blind, randomized, integrated phase I/phase III stu... |
PMC8097471 | core_pubmed_pmc | Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria | Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria Abstract Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consi... |
PMC5824109 | core_pubmed_pmc | Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research | Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research Abstract Abstract Drug interaction is a leading cause of adverse drug events and a major obstacle for current clinical practice. Pharmacovigilance data mining, pharmacokinetic modeling, and text mining are computation ... |
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