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PMC5215447 | core_pubmed_pmc | Duration of action of two insulin glargine products, LY2963016 insulin glargine and Lantus insulin glargine, in subjects with type 1 diabetes mellitus | Duration of action of two insulin glargine products, LY2963016 insulin glargine and Lantus insulin glargine, in subjects with type 1 diabetes mellitus Abstract Abstract Aims LY2963016 (LY IGlar) and Lantus (IGlar) are insulin glargine products manufactured by distinct processes, but with identical amino acid sequences.... |
PMC12955502 | core_pubmed_pmc | BANTAM-01: A Multicenter, Open-Label, First-in-Human Phase 1 Dose Escalation and Expansion Study of 225 Ac-GPC3 (BAY 3547926) in Patients with Advanced Hepatocellular Carcinoma | BANTAM-01: A Multicenter, Open-Label, First-in-Human Phase 1 Dose Escalation and Expansion Study of 225 Ac-GPC3 (BAY 3547926) in Patients with Advanced Hepatocellular Carcinoma Abstract Despite the increasing availability of systemic therapies to treat advanced hepatocellular carcinoma (HCC), the prognosis remains poor... |
PMC10618645 | core_pubmed_pmc | Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study | Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study Abstract Abstract Purpose: This phase Ib study defined the safety, MTD, and recommended phase II dose (RP2D) of regorafenib combined with vincristine and irinote... |
PMC11365891 | core_pubmed_pmc | Molecular docking and antimicrobial activities of photoexcited inhibitors in antimicrobial photodynamic therapy against Enterococcus faecalis biofilms in endodontic infections | Molecular docking and antimicrobial activities of photoexcited inhibitors in antimicrobial photodynamic therapy against Enterococcus faecalis biofilms in endodontic infections Abstract Abstract Antimicrobial photodynamic therapy (aPDT) is a promising approach to combat antibiotic resistance in endodontic infections. It... |
PMC11984503 | core_pubmed_pmc | Large Language Models and Their Applications in Drug Discovery and Development: A Primer | Large Language Models and Their Applications in Drug Discovery and Development: A Primer Abstract ABSTRACT Large language models (LLMs) have emerged as powerful tools in many fields, including clinical pharmacology and translational medicine. This paper aims to provide a comprehensive primer on the applications of LLMs... |
PMC10206108 | core_pubmed_pmc | Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants | Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants Abstract Abstract N,N -dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and the... |
PMC11458342 | core_pubmed_pmc | Determination of a robust headspace GC-MS/MS method for analysis of ethyl alcohol and acetaldehyde: clinical application to pharmacokinetics study | Determination of a robust headspace GC-MS/MS method for analysis of ethyl alcohol and acetaldehyde: clinical application to pharmacokinetics study Abstract Abstract Due to the forensic aspects of drinking and exposure to toxic substances, more sophisticated quantitative technology is needed to quantify the concentratio... |
PMC5813272 | core_pubmed_pmc | A first‐in‐human pharmacodynamic and pharmacokinetic study of a fully human anti‐glucagon receptor monoclonal antibody in normal healthy volunteers | A first‐in‐human pharmacodynamic and pharmacokinetic study of a fully human anti‐glucagon receptor monoclonal antibody in normal healthy volunteers Abstract Aims Glucagon receptor (GCGR) blockers are being investigated as potential therapeutics for type 1 and type 2 diabetes. Here we report the safety, tolerability, ph... |
PMC10374249 | core_pubmed_pmc | A network pharmacology approach to decipher the total flavonoid extract of Dracocephalum Moldavica L. in the treatment of cerebral ischemia- reperfusion injury | A network pharmacology approach to decipher the total flavonoid extract of Dracocephalum Moldavica L. in the treatment of cerebral ischemia- reperfusion injury Abstract Background and objective Cerebral ischemia-reperfusion injury (CIRI) is a major injury that seriously endangers human health and is characterized by hi... |
PMC8301595 | core_pubmed_pmc | Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease | Population pharmacokinetic analysis of apomorphine sublingual film or subcutaneous apomorphine in healthy subjects and patients with Parkinson’s disease Abstract Abstract Apomorphine is an on‐demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD). A joint parent‐metabolite population pharmacokinet... |
PMC12292357 | core_pubmed_pmc | Targeting Glypican-3 in Liver Cancer: Groundbreaking Preclinical and Clinical Insights | Targeting Glypican-3 in Liver Cancer: Groundbreaking Preclinical and Clinical Insights Abstract Abstract Positron emission tomography (PET) imaging targeting glypican-3 (GPC3) holds promise for improving the detection and characterization of hepatocellular carcinoma (HCC). Preclinical and early clinical studies have la... |
PMC8511024 | core_pubmed_pmc | In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent | In silico and multi-spectroscopic analyses on the interaction of 5-amino-8-hydroxyquinoline and bovine serum albumin as a potential anticancer agent Abstract 5-Amino-8-hydroxyquinoline (5A8HQ), an amino derivative of 8-hydroxyquinoline, has become a potential anticancer candidate because of its promising proteasome inh... |
PMC12632142 | core_pubmed_pmc | De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors | De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors Abstract Background Although antibody-conjugated drugs have achieved success in clinical practice for cancer treatment, challenges remain in developing a highly efficient drug delivery system with specific accumulation ... |
PMC9652446 | core_pubmed_pmc | CYP2C8 *3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride | CYP2C8 *3 and *4 define CYP2C8 phenotype: An approach with the substrate cinitapride Abstract Abstract Cinitapride is a gastrointestinal prokinetic drug, prescribed for the treatment of functional dyspepsia, and as an adjuvant therapy for gastroesophageal reflux disease. In this study, we aimed to explore the impact of... |
PMC11587513 | core_pubmed_pmc | Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics | Evaluation of Alpha-Synuclein and Tau Antiaggregation Activity of Urea and Thiourea-Based Small Molecules for Neurodegenerative Disease Therapeutics Abstract Alzheimer’s disease (AD) and Parkinson’s disease (PD) are multifactorial, chronic diseases involving neurodegeneration. According to recent studies, it is hypothe... |
PMC3731827 | core_pubmed_pmc | Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content | Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content Abstract Abstract Sirolimus is an inhibitor of mammalian target of rapamycin (mTOR) and is increasingly being used in transplantation and cancer therapies. Sirolimus has low oral bioa... |
PMC7037321 | core_pubmed_pmc | Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry | Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry Abstract Abstract SH-1242, a novel inhibitor of heat shock protein 90 (HSP90), is a synthetic analog of deguelin: It was previously reported that the treatment of SH-1242 led to a st... |
PMC6222633 | core_pubmed_pmc | Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method | Preclinical Pharmacokinetics of Scoparone, Geniposide and Rhein in an Herbal Medicine Using a Validated LC-MS/MS Method Abstract Abstract The herbal formula Yin-Chen-Hao-Tang has been reported to have anti-fibrosis properties. The aim of this study was to reveal the pharmacokinetic characteristics of bioactive compound... |
PMC12353758 | core_pubmed_pmc | Pharmacokinetic Characterization of Iopamidol and Iohexol for Optimizing Measured Glomerular Filtration Rate Assessment in Clinical Practice and Drug Development | Pharmacokinetic Characterization of Iopamidol and Iohexol for Optimizing Measured Glomerular Filtration Rate Assessment in Clinical Practice and Drug Development Abstract Abstract Accurate kidney function assessment supports healthcare and clinical decision‐making in practice and drug development. Measured glomerular f... |
PMC6373390 | core_pubmed_pmc | Comparison of the Pharmacokinetic–Pharmacodynamic Relationships of Two Darbepoetin Alfa Formulations in Healthy Male Volunteers | Comparison of the Pharmacokinetic–Pharmacodynamic Relationships of Two Darbepoetin Alfa Formulations in Healthy Male Volunteers Abstract Objective This study compared the pharmacokinetic (PK), pharmacodynamic (PD), and safety properties of the test (CJ-40001) and reference (NESP ® ) versions of darbepoetin alfa followi... |
PMC8114543 | core_pubmed_pmc | Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex | Population Pharmacokinetics and Initial Dose Optimization of Sirolimus Improving Drug Blood Level for Seizure Control in Pediatric Patients With Tuberous Sclerosis Complex Abstract The purposes of this study were to explore the population pharmacokinetics and initial dose optimization of sirolimus improving drug blood ... |
PMC7581827 | core_pubmed_pmc | Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties | Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties Abstract Abstract Nanoparticle technology in cancer chemotherapy is a promising approach to enhance active ingredient pharmacology and pharmacodynamics. Indeed, drug nan... |
PMC12567778 | core_pubmed_pmc | Pharmacokinetic Comparison of Tylvalosin Tartrate Nanocrystal Suspension and Soluble Powder in Broiler Chickens After Oral and Intravenous Administration | Pharmacokinetic Comparison of Tylvalosin Tartrate Nanocrystal Suspension and Soluble Powder in Broiler Chickens After Oral and Intravenous Administration Abstract Simple Summary This study evaluated how tylvalosin behaves in chickens when given as two different oral formulations—a nanocrystalline suspension and a solub... |
PMC9305234 | core_pubmed_pmc | Pharmacogenomic alerts: Developing guidance for use by healthcare professionals | Pharmacogenomic alerts: Developing guidance for use by healthcare professionals Abstract Abstract Aims For diseases with a genetic cause, genomics can deliver improved diagnostics and facilitate access to targeted treatments. Drug pharmacodynamics and pharmacokinetics are often dependent on genetic variation underlying... |
PMC6880184 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers | Pharmacokinetic/pharmacodynamic modeling and simulation of dotinurad, a novel uricosuric agent, in healthy volunteers Abstract Abstract This study aimed to investigate the pharmacokinetic and pharmacodynamic (PK/PD) profiles of dotinurad, a novel uricosuric agent, and to construct a PK/PD model to predict serum urate (... |
PMC4799925 | core_pubmed_pmc | Population pharmacokinetics of tanezumab in phase 3 clinical trials for osteoarthritis pain | Population pharmacokinetics of tanezumab in phase 3 clinical trials for osteoarthritis pain Abstract Aims The aims were to 1) develop the pharmacokinetics model to describe and predict observed tanezumab concentrations over time, 2) test possible covariate parameter relationships that could influence clearance and dist... |
PMC3909010 | core_pubmed_pmc | Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes | Pharmacogenetic-Based Efavirenz Dose Modification: Suggestions for an African Population and the Different CYP2B6 Genotypes Abstract Abstract Background Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purp... |
PMC10051807 | core_pubmed_pmc | Efficacy, Tolerability, and Safety of Toludesvenlafaxine for the Treatment of Major Depressive Disorder—A Narrative Review | Efficacy, Tolerability, and Safety of Toludesvenlafaxine for the Treatment of Major Depressive Disorder—A Narrative Review Abstract Abstract The estimated rate of treatment-resistant major depressive disorder (TRD) remains higher than 30%, even after the discovery of multiple classes of antidepressants in the last 7 de... |
PMC9107402 | core_pubmed_pmc | Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans | Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans Abstract Abstract Purpose To investigate the suitability of microdosed oral omeprazole for predicting CYP2C19 activity in vivo in combination with simultaneous assessment of CYP3A and CYP2D6 activity using both microdosed midazolam and yohimbine.... |
PMC5378280 | core_pubmed_pmc | Carfilzomib, lenalidomide and dexamethasone in patients with heavily pretreated multiple myeloma: A phase 1 study in Japan | Carfilzomib, lenalidomide and dexamethasone in patients with heavily pretreated multiple myeloma: A phase 1 study in Japan Abstract This is the first study in which the carfilzomib, lenalidomide and dexamethasone ( KR d) regimen was evaluated in heavily pretreated multiple myeloma. This study is a multicenter, open‐lab... |
PMC3392695 | core_pubmed_pmc | Specific safety and tolerability considerations in the use of anticonvulsant medications in children | Specific safety and tolerability considerations in the use of anticonvulsant medications in children Abstract Abstract Epilepsy is one of the most common neurological disorders in the pediatric age range, and the majority of affected children can be safely and effectively treated with antiepileptic medication. While th... |
PMC8382006 | core_pubmed_pmc | Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody | Safety, tolerability, pharmacokinetic characteristics, and immunogenicity of MW33: a Phase 1 clinical study of the SARS-CoV-2 RBD-targeting monoclonal antibody Abstract ABSTRACT MW33 is a fully humanized IgG1κ monoclonal neutralizing antibody, and may be used for the prevention and treatment of coronavirus disease 2019... |
PMC6632166 | core_pubmed_pmc | Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy | Study Protocol for a Pilot, Open-Label, Prospective, and Observational Study to Evaluate the Pharmacokinetics of Drugs Administered to Patients during Extracorporeal Circulation; Potential of In Vivo Cytochrome P450 Phenotyping to Optimise Pharmacotherapy Abstract Pharmacokinetic alterations of medications administered... |
PMC4937137 | core_pubmed_pmc | Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide | Oral absorption profiles of sulfonamides in Shiba goats: a comparison among sulfadimidine, sulfadiazine and sulfanilamide Abstract Abstract The oral pharmacokinetics of three sulfonamides, sulfadimidine (pKa 7.5), sulfadiazine (pKa 6.5) and sulfanilamide (pKa 10.5), with different rates of unionization in rumen juice, ... |
PMC9360077 | core_pubmed_pmc | Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances | Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances Abstract Abstract The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and par... |
PMC7744997 | core_pubmed_pmc | Pharmacokinetics, Safety, and Antiviral Effects of Multiple Doses of the Respiratory Syncytial Virus (RSV) Fusion Protein Inhibitor, JNJ-53718678, in Infants Hospitalized With RSV Infection: A Randomized Phase 1b Study | Pharmacokinetics, Safety, and Antiviral Effects of Multiple Doses of the Respiratory Syncytial Virus (RSV) Fusion Protein Inhibitor, JNJ-53718678, in Infants Hospitalized With RSV Infection: A Randomized Phase 1b Study Abstract Abstract Background This phase 1b study evaluated the pharmacokinetics, safety, and antivira... |
PMC12804923 | core_pubmed_pmc | Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies | Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies Abstract Abstract Curcuma genus has been widely used in folk medicine for its diverse medicinal properties. This study explored the in vitro and in vivo anti-inflammatory activ... |
PMC5296599 | core_pubmed_pmc | A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis | A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis Abstract ABSTRACT Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioe... |
PMC3668874 | core_pubmed_pmc | Tutorial in oral antithrombotic therapy: Biology and dental implications | Tutorial in oral antithrombotic therapy: Biology and dental implications Abstract Abstract Objectives: Recent developments of new direct oral anticoagulants that target specific clotting factors necessitate understanding of coagulation biology. The objective of this tutorial is to offer dental professionals a review of... |
PMC4302682 | core_pubmed_pmc | Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer | Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer Abstract Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tum... |
PMC8518898 | core_pubmed_pmc | Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites | Effects of Hepatic Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites Abstract Abstract Abrocitinib, an oral once‐daily Janus kinase 1 selective inhibitor, is under development for treatment of atopic dermatitis. This phase 1, nonrandomized, open‐label, single‐dose study ( NCT03626415 ) investigated ... |
PMC5686255 | core_pubmed_pmc | Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization | Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization Abstract Background Pazopanib is an angiogenesis inhibitor approved for the treatment of renal cell carcinoma and soft tissue sarcoma. Post hoc analysis of a clinical trial demonstrated ... |
PMC10374676 | core_pubmed_pmc | Individual hematotoxicity prediction of further chemotherapy cycles by dynamic mathematical models in patients with gastrointestinal tumors | Individual hematotoxicity prediction of further chemotherapy cycles by dynamic mathematical models in patients with gastrointestinal tumors Abstract Purpose Hematotoxicity is a common side-effect of cytotoxic gastrointestinal (GI) cancer therapies. An unsolved problem is to predict the individual risk therefore to deci... |
PMC8235426 | core_pubmed_pmc | Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy | Novel Applications of NSAIDs: Insight and Future Perspectives in Cardiovascular, Neurodegenerative, Diabetes and Cancer Disease Therapy Abstract Abstract Once it became clear that inflammation takes place in the modulation of different degenerative disease including neurodegenerative, cardiovascular, diabetes and cance... |
PMC11337195 | core_pubmed_pmc | A comparative evaluation of bioequivalence of Gan & Lee glargine U300 and Toujeo ® in Chinese healthy male participants | A comparative evaluation of bioequivalence of Gan & Lee glargine U300 and Toujeo ® in Chinese healthy male participants Abstract Background To assess the bioequivalence between Gan & Lee (GL) glargine U300 and Toujeo ® regarding pharmacokinetics (PK), pharmacodynamics (PD), and safety in Chinese healthy male participan... |
PMC9913332 | core_pubmed_pmc | Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue | Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue Abstract Abstract Simple Summary The maintenance of the structural integrity of therapeutic proteins in the target tissue is crucial to their proper function. In this study, we aimed to assess the in vivo s... |
PMC12823300 | core_pubmed_pmc | Population Pharmacokinetics of Asundexian in People at Risk for Thromboembolic/Cardiovascular Events | Population Pharmacokinetics of Asundexian in People at Risk for Thromboembolic/Cardiovascular Events Abstract ABSTRACT Asundexian is a potent, selective, and reversible inhibitor of activated clotting Factor XI currently under development for secondary prevention of recurrent ischemic stroke in the ongoing Phase III OC... |
PMC8424104 | core_pubmed_pmc | Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center | Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center Abstract Highlights • The majority of patients with high lamotrigine and levetiracetam serum/plasma levels were asymptomatic. • Common symptoms associated with high lam... |
PMC7405010 | core_pubmed_pmc | Neotropical Rattlesnake ( Crotalus simus ) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model | Neotropical Rattlesnake ( Crotalus simus ) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model Abstract Abstract The most abundant protein families in viper venoms are Snake Venom Metalloproteases (SVMPs), Snake Venom Serine Proteases (SVSPs) and Phospholipases (PLA 2 s). These are primarily responsible for ... |
PMC3056842 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC | Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC Abstract Background In many malaria-endemic countries, increasing resistance may soon compromise the efficacy of sulphadoxine-pyrimetha... |
PMC10854759 | core_pubmed_pmc | Chestnut Wood Tannins in Broiler Diets: Pharmacokinetics, Serum Levels during Rearing, and Intestinal Absorption Pattern of Gallic Acid | Chestnut Wood Tannins in Broiler Diets: Pharmacokinetics, Serum Levels during Rearing, and Intestinal Absorption Pattern of Gallic Acid Abstract Abstract Studies on the bioavailability, serum levels, and absorption of hydrolyzable tannin compounds are lacking. In this study, we performed a pharmacokinetic trial, measur... |
PMC12027902 | core_pubmed_pmc | Drug Administration Before or After Exposure to Low Temperatures—Does It Matter for the Therapeutic Effect? | Drug Administration Before or After Exposure to Low Temperatures—Does It Matter for the Therapeutic Effect? Abstract The adaptation of the body when exposed to a lower-than-usual temperature is a challenge that involves neuro-endocrine–immune mechanisms and affects the pharmacokinetics and/or pharmacodynamics of drugs ... |
PMC7982615 | core_pubmed_pmc | Phase 1 study of telisotuzumab vedotin in Japanese patients with advanced solid tumors | Phase 1 study of telisotuzumab vedotin in Japanese patients with advanced solid tumors Abstract ABSTRACT Telisotuzumab vedotin (formerly ABBV‐399) is an antibody‐drug conjugate targeting c‐Met–overexpressing tumor cells, irrespective of MET gene amplification status. Safety, pharmacokinetics, and preliminary efficacy o... |
PMC9868619 | core_pubmed_pmc | Population pharmacokinetics and dose evaluations of linezolid in the treatment of multidrug-resistant tuberculosis | Population pharmacokinetics and dose evaluations of linezolid in the treatment of multidrug-resistant tuberculosis Abstract Background: The pharmacokinetic/pharmacodynamics (PK/PD) target derived from the hollow-fiber system model for linezolid for treatment of the multidrug-resistant tuberculosis (MDR-TB) requires cli... |
PMC8924582 | core_pubmed_pmc | Polysaccharide-Zein Composite Nanoparticles for Enhancing Cellular Uptake and Oral Bioavailability of Curcumin: Characterization, Anti-colorectal Cancer Effect, and Pharmacokinetics | Polysaccharide-Zein Composite Nanoparticles for Enhancing Cellular Uptake and Oral Bioavailability of Curcumin: Characterization, Anti-colorectal Cancer Effect, and Pharmacokinetics Abstract Abstract Curcumin (CUR) has demonstrated promising potential as a therapeutic agent against colorectal cancer (CRC). However, its... |
PMC7731723 | core_pubmed_pmc | Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics | Long-term study of oral treprostinil to treat pulmonary arterial hypertension: dosing, tolerability, and pharmacokinetics Abstract Abstract Oral treprostinil may be an option for low- and intermediate-risk patients with pulmonary arterial hypertension, a rare lung vascular disease. This open-label extension study colle... |
PMC3710981 | core_pubmed_pmc | Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions | Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions Abstract Abstract Objective Clarithromycin strongly inhibits enzyme cytochrome P450 3A4, preventing the metabolism of some other drugs, while azithromycin is a weak inhibitor. Accordingly, blood concentrations o... |
PMC9155609 | core_pubmed_pmc | Drug concentration at the site of disease in children with pulmonary tuberculosis | Drug concentration at the site of disease in children with pulmonary tuberculosis Abstract Abstract Background Current TB treatment for children is not optimized to provide adequate drug levels in TB lesions. Dose optimization of first-line antituberculosis drugs to increase exposure at the site of disease could facili... |
PMC9505877 | core_pubmed_pmc | Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients | Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients Abstract Abstract Voriconazole (VRC) is used as first line antifungal agent against invasive aspergillosis. Model-based approaches might optimize VRC therapy. This study a... |
PMC8762298 | core_pubmed_pmc | Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury | Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury Abstract Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower survival and increased economic burden, there is no pharm... |
PMC12828103 | core_pubmed_pmc | Effects of cannabidiol in alcohol use disorder patients with and without co‐occurring post‐traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof‐of‐concept trials | Effects of cannabidiol in alcohol use disorder patients with and without co‐occurring post‐traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof‐of‐concept trials Abstract Abstract Background Comorbidity between alcohol use disorder (AUD) and post‐traumatic stress disorder (PTSD) ... |
PMC6154694 | core_pubmed_pmc | Absorption, Metabolic Stability, and Pharmacokinetics of Ginger Phytochemicals | Absorption, Metabolic Stability, and Pharmacokinetics of Ginger Phytochemicals Abstract Abstract We have previously demonstrated promising anticancer efficacy of orally-fed whole ginger extract (GE) in preclinical prostate models emphasizing the importance of preservation of the natural “milieu”. Essentially, GE primar... |
PMC11132457 | core_pubmed_pmc | Evaluation of pharmacokinetics, safety, and efficacy of [ 211 At] meta-astatobenzylguanidine ([ 211 At] MABG) in patients with pheochromocytoma or paraganglioma (PPGL): A study protocol | Evaluation of pharmacokinetics, safety, and efficacy of [ 211 At] meta-astatobenzylguanidine ([ 211 At] MABG) in patients with pheochromocytoma or paraganglioma (PPGL): A study protocol Abstract Background Pheochromocytoma, or paraganglioma (PPGL), is a tumor that arises from catecholamine-producing chromaffin cells of... |
PMC5552306 | core_pubmed_pmc | Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole in ephemeral vegetables | Assessment of veterinary drugs in plants using pharmacokinetic approaches: The absorption, distribution and elimination of tetracycline and sulfamethoxazole in ephemeral vegetables Abstract The present study was carried out to demonstrate novel use of pharmacokinetic approaches to characterize drug behaviors/movements ... |
PMC3337406 | core_pubmed_pmc | Exposure–response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection | Exposure–response relationship of AMG 386 in combination with weekly paclitaxel in recurrent ovarian cancer and its implication for dose selection Abstract Purpose To characterize exposure–response relationships of AMG 386 in a phase 2 study in advanced ovarian cancer for the facilitation of dose selection in future st... |
PMC9486186 | core_pubmed_pmc | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells Abstract Abstract Purinostat Mesylate (PM) is a novel highly selective and active HDAC I/IIb inhibitor, and the injectable formulation of PM (PMF) based on the compound prescription containing cyclodex... |
PMC11350925 | core_pubmed_pmc | Impact of Empirical Antimicrobial Treatment on Patients with Ventilator-Associated Pneumonia Due to Stenotrophomonas maltophilia | Impact of Empirical Antimicrobial Treatment on Patients with Ventilator-Associated Pneumonia Due to Stenotrophomonas maltophilia Abstract Abstract This retrospective study was conducted to evaluate the characteristics and outcomes of patients with ventilator-associated pneumonia (VAP) caused by Stenotrophomonas maltoph... |
PMC10393876 | core_pubmed_pmc | In vitro activity of cefiderocol against MBL-producing Gram-negative bacteria collected in North America and Europe in five consecutive annual multinational SIDERO-WT surveillance studies (2014–2019) | In vitro activity of cefiderocol against MBL-producing Gram-negative bacteria collected in North America and Europe in five consecutive annual multinational SIDERO-WT surveillance studies (2014–2019) Abstract Abstract Objectives To evaluate the in vitro antibacterial activity of cefiderocol, a siderophore cephalosporin... |
PMC8272101 | core_pubmed_pmc | Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns | Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns Abstract Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant origin and are abundantly found in human diet such as fruits, vegetables, grains, t... |
PMC11595998 | core_pubmed_pmc | Characterization of a New Hsp110 Inhibitor as a Potential Antifungal | Characterization of a New Hsp110 Inhibitor as a Potential Antifungal Abstract Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protei... |
PMC10740629 | core_pubmed_pmc | Could an Optimized Joint Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin-Tazobactam Be a Valuable Innovative Approach for Maximizing the Effectiveness of Monotherapy Even in the Treatment of Critically Ill Patients with Documented Extended-Spectrum Beta-Lactamase-Producing Enteroba... | Could an Optimized Joint Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin-Tazobactam Be a Valuable Innovative Approach for Maximizing the Effectiveness of Monotherapy Even in the Treatment of Critically Ill Patients with Documented Extended-Spectrum Beta-Lactamase-Producing Enteroba... |
PMC5438075 | core_pubmed_pmc | ABCB1 genetic variants in leukemias: current insights into treatment outcomes | ABCB1 genetic variants in leukemias: current insights into treatment outcomes Abstract Abstract Despite improvements in treatment of different types of leukemia, not all patients respond optimally for a particular treatment. Some treatments will work better for some, while being harmful or ineffective for others. This ... |
PMC9306447 | core_pubmed_pmc | A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma | A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma Abstract Abstract Purpose: Ceritinib is an orally bioavailable, small-molecule inhibitor of anaplastic lympoma kinase (ALK), insulin-like growth factor 1 receptor (IGFR1), and focal adhesion kinase (FAK), which are highly expresse... |
PMC6749594 | core_pubmed_pmc | Simultaneous Quantification and Pharmacokinetic Study of Nine Bioactive Components of Orthosiphon stamineus Benth. Extract in Rat Plasma by UHPLC-MS/MS | Simultaneous Quantification and Pharmacokinetic Study of Nine Bioactive Components of Orthosiphon stamineus Benth. Extract in Rat Plasma by UHPLC-MS/MS Abstract Orthosiphon stamineus Benth. (OS) is a traditional folk medicine for the treatment of kidney stones and other urinary tract diseases. In this study, a rapid an... |
PMC5499931 | core_pubmed_pmc | Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors | Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors Abstract Abstract This phase I study aimed at determining the maximum tolerated dose (MTD) and characterizing the safety, tolerability, pharmacokinetics (PKs), and efficacy of pasireotide in patients with advanced neuroendoc... |
PMC3917539 | core_pubmed_pmc | Nanoparticle albumin-bound paclitaxel in a patient with locally advanced breast cancer and taxane-induced skin toxicity: a case report | Nanoparticle albumin-bound paclitaxel in a patient with locally advanced breast cancer and taxane-induced skin toxicity: a case report Abstract Abstract Introduction Taxanes have demonstrated effectiveness in the treatment of breast cancer, the most common type of cancer in women. The toxicity profile of taxanes (inclu... |
PMC12022156 | core_pubmed_pmc | Exploring the anti-inflammatory activity of fupenzic acid using network pharmacology and experimental validation | Exploring the anti-inflammatory activity of fupenzic acid using network pharmacology and experimental validation Abstract Crataegus azarolus L. (Rosaceae), commonly known as Mediterranean hawthorn, has long been valued in Traditional Medicine for treating cardiovascular and inflammation-related diseases, including diab... |
PMC11578132 | core_pubmed_pmc | A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk | A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk Abstract Abstract Breastfeeding is the most complete nutritional method of feeding infants, but several impediments affect the decision to breastfeed, including questions of drug safety for medications needed during l... |
PMC12060160 | core_pubmed_pmc | Impact of the loss of slc43a3 on 6-mercaptopurine absorption and tissue distribution in mice | Impact of the loss of slc43a3 on 6-mercaptopurine absorption and tissue distribution in mice Abstract Abstract 6-Mercaptopurine (6-MP) is a nucleobase analog used in the therapy of acute lymphoblastic leukemia and inflammatory bowel disease. It is associated with numerous side effects including myelotoxicity, hepatotox... |
PMC10249425 | core_pubmed_pmc | Ramucirumab for Patients with Advanced Hepatocellular Carcinoma and Elevated Alpha Fetoprotein Following Non–Sorafenib Systemic Therapy: An Expansion Cohort of REACH-2 | Ramucirumab for Patients with Advanced Hepatocellular Carcinoma and Elevated Alpha Fetoprotein Following Non–Sorafenib Systemic Therapy: An Expansion Cohort of REACH-2 Abstract Abstract Background Ramucirumab is indicated for patients with advanced hepatocellular carcinoma (HCC) and α-fetoprotein (AFP) ≥400 ng/mL follo... |
PMC11492916 | core_pubmed_pmc | Cytotoxic Evaluation, Molecular Docking, Molecular Dynamics, and ADMET Prediction of Isolupalbigenin Isolated from Erythrina subumbrans (Hassk). Merr. (Fabaceae) Stem Bark: Unveiling Its Anticancer Efficacy | Cytotoxic Evaluation, Molecular Docking, Molecular Dynamics, and ADMET Prediction of Isolupalbigenin Isolated from Erythrina subumbrans (Hassk). Merr. (Fabaceae) Stem Bark: Unveiling Its Anticancer Efficacy Abstract Introduction Erythrina subumbrans , a medical plant found in sub-Saharan Africa and the Western Ghats of... |
PMC11097972 | core_pubmed_pmc | Ex vivo pharmacokinetic/pharmacodynamic of hexahydrocolupulone against Clostridium perfringens in broiler chickens | Ex vivo pharmacokinetic/pharmacodynamic of hexahydrocolupulone against Clostridium perfringens in broiler chickens Abstract The economic impact of necrotizing enteritis (NE) resulting from Clostridium perfringens infection has been significant within the broiler industry. This study primarily investigated the antibacte... |
PMC4166663 | core_pubmed_pmc | Distribution of Intravenously Administered Acetylcholinesterase Inhibitor and Acetylcholinesterase Activity in the Adrenal Gland: 11 C-Donepezil PET Study in the Normal Rat | Distribution of Intravenously Administered Acetylcholinesterase Inhibitor and Acetylcholinesterase Activity in the Adrenal Gland: 11 C-Donepezil PET Study in the Normal Rat Abstract Abstract Purpose Acetylcholinesterase (AChE) inhibitors have been used for patients with Alzheimer's disease. However, its pharmacokinetic... |
PMC6125117 | core_pubmed_pmc | Overview of pharmacogenomic testing in clinical practice | Overview of pharmacogenomic testing in clinical practice Abstract Introduction: Pharmacogenomic tests relevant to neuropsychiatric medications have been clinically available for more than a decade, but the utility of regular testing is still unknown. Tests available include both pharmacokinetic and pharmacodynamic targ... |
PMC12630578 | core_pubmed_pmc | Pharmacokinetics and abbreviated AUC model of enteric-coated mycophenolate sodium in early kidney transplant recipients receiving tacrolimus | Pharmacokinetics and abbreviated AUC model of enteric-coated mycophenolate sodium in early kidney transplant recipients receiving tacrolimus Abstract Abstract Enteric-coated mycophenolate sodium (EC-MPS) is used in kidney transplant recipients (KTRs) as an alternative to mycophenolate mofetil for improved gastrointesti... |
PMC9136157 | core_pubmed_pmc | The CSF Vancomycin Concentration in Patients With Post-operative Intracranial Infection Can Be Predicted by the WBCs to Total Cells Ratio and the Serum Trough Concentration | The CSF Vancomycin Concentration in Patients With Post-operative Intracranial Infection Can Be Predicted by the WBCs to Total Cells Ratio and the Serum Trough Concentration Abstract Background The pharmacokinetics of vancomycin in cerebrospinal fluid (CSF) is an important basis for evaluating the bactericidal effect. T... |
PMC11233998 | core_pubmed_pmc | Determination of mitomycin C in rat plasma by liquid chromatography-tandem mass spectrometry and its application for determining pharmacokinetics in rat | Determination of mitomycin C in rat plasma by liquid chromatography-tandem mass spectrometry and its application for determining pharmacokinetics in rat Abstract Abstract To develop the liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring mitomycin C in rat plasma, samples were processed using... |
PMC12923928 | core_pubmed_pmc | The magnitude of drug-related problems, typology, and predictors among patients admitted to the pediatric intensive care unit: impact of pharmacist-led interventions in Northwest Ethiopia | The magnitude of drug-related problems, typology, and predictors among patients admitted to the pediatric intensive care unit: impact of pharmacist-led interventions in Northwest Ethiopia Abstract Background: Drug-related problems (DRPs) are a significant concern in hospitalized patients. In Ethiopia, DRPs occur at a r... |
PMC5709938 | core_pubmed_pmc | Performance comparison of first-order conditional estimation with interaction and Bayesian estimation methods for estimating the population parameters and its distribution from data sets with a low number of subjects | Performance comparison of first-order conditional estimation with interaction and Bayesian estimation methods for estimating the population parameters and its distribution from data sets with a low number of subjects Abstract Abstract Background Exploratory preclinical, as well as clinical trials, may involve a small n... |
PMC3835890 | core_pubmed_pmc | Targeting TNF-α and NF-κB Activation by Bee Venom: Role in Suppressing Adjuvant Induced Arthritis and Methotrexate Hepatotoxicity in Rats | Targeting TNF-α and NF-κB Activation by Bee Venom: Role in Suppressing Adjuvant Induced Arthritis and Methotrexate Hepatotoxicity in Rats Abstract Low dose methotrexate is the cornerstone for the treatment of rheumatoid arthritis. One of its major drawbacks is hepatotoxicity, resulting in poor compliance of therapy. Di... |
PMC5811889 | core_pubmed_pmc | Pharmacokinetics of a Novel Anagrelide Extended‐Release Formulation in Healthy Subjects: Food Intake and Comparison With a Reference Product | Pharmacokinetics of a Novel Anagrelide Extended‐Release Formulation in Healthy Subjects: Food Intake and Comparison With a Reference Product Abstract Abstract Anagrelide is an established therapy for essential thrombocythemia. Common adverse effects have been linked to peak plasma concentrations of anagrelide and its 3... |
PMC9203451 | core_pubmed_pmc | Tacrolimus dose adjustment is not necessary in dose to dose conversion from a twice daily to a prolonged release once daily dose form | Tacrolimus dose adjustment is not necessary in dose to dose conversion from a twice daily to a prolonged release once daily dose form Abstract Abstract Twice daily TAC (BID TAC) and prolonged released once daily dose tacrolimus (OD TAC) have different pharmacokinetic (PK) profiles in kidney transplant (KT) recipients. ... |
PMC9321600 | core_pubmed_pmc | Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols | Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols Abstract Abstract The health benefits associated with (poly)phenols need to be supported by robust and insightful information on their biological effects. The use of in vitro , ex vivo , and in vivo models is cr... |
PMC8705744 | core_pubmed_pmc | Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections | Preparation and In Vitro-In Vivo Evaluation of Luteolin Loaded Gastroretentive Microsponge for the Eradication of Helicobacter pylori Infections Abstract The current study aimed to develop a luteolin gastric floating microsponge for targeting Helicobacter pylori . The microsponge formulations were prepared by a quasi-e... |
PMC11946220 | core_pubmed_pmc | Development and Characterization of Printlets of Lamivudine for Pediatric Patients Using Selective Laser Sintering | Development and Characterization of Printlets of Lamivudine for Pediatric Patients Using Selective Laser Sintering Abstract Abstract Background: Lamivudine is widely used alone or in combination with other anti-HIV drugs in the infant to adolescent age groups of pediatric populations. Compounding of medications is freq... |
PMC8225049 | core_pubmed_pmc | Scaling Approaches for Pediatric Dose Selection: The Fremanezumab (AJOVY ® ) Journey to Select a Phase 3 Dose Using Pharmacokinetic Data from a Phase 1 Study | Scaling Approaches for Pediatric Dose Selection: The Fremanezumab (AJOVY ® ) Journey to Select a Phase 3 Dose Using Pharmacokinetic Data from a Phase 1 Study Abstract Abstract Fremanezumab, a fully humanized IgG2Δa/kappa monoclonal antibody, selectively targets the calcitonin-gene-related peptide (CGRP) and prevents it... |
PMC12590278 | core_pubmed_pmc | Design and systematic evaluation of novel chemical modification patterns enable the identification of a potent siRNA targeting PCSK9 | Design and systematic evaluation of novel chemical modification patterns enable the identification of a potent siRNA targeting PCSK9 Abstract Abstract Fully modified small interfering RNAs (siRNAs) have demonstrated remarkable advantages in medicine development since they enable the knockdown of the majority of disease... |
PMC11253443 | core_pubmed_pmc | Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation | Preparation and in vivo and ex vivo studies of sirolimus nano-in-situ gel ophthalmic formulation Abstract Abstract Sirolimus (SR) is a macrolide with antifungal and antitumor immunosuppressant properties, classified as a selective inhibitor of mammalian target of rapamycin (mTOR). In this study, an ionic in situ gel of... |
PMC3580802 | core_pubmed_pmc | Role of Statistical Random-Effects Linear Models in Personalized Medicine | Role of Statistical Random-Effects Linear Models in Personalized Medicine Abstract Abstract Some empirical studies and recent developments in pharmacokinetic theory suggest that statistical random-effects linear models are valuable tools that allow describing simultaneously patient populations as a whole and patients a... |
PMC11889805 | core_pubmed_pmc | Development of a bispecific antibody–drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors | Development of a bispecific antibody–drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors Abstract Abstract Epithelial cell adhesion molecule (EpCAM), a tumor antigen for antibody–drug conjugates (ADCs), is highly expressed in many epithelial cancers. However, the clinical progress of EpC... |
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