id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC12348855 | core_pubmed_pmc | Catechins and Human Health: Breakthroughs from Clinical Trials | Catechins and Human Health: Breakthroughs from Clinical Trials Abstract Green tea, derived from the unoxidized leaves of Camellia sinensis (L.) Kuntze, is one of the least processed types of tea and is rich in antioxidants and polyphenols. Among these, catechins—particularly epigallocatechin gallate (EGCG)—play a key r... |
PMC7328978 | core_pubmed_pmc | Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition | Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition Abstract Abstract Introduction: Targeted biologic therapies demonstrate similar efficacies in rheumatoid arthritis despite distinct mechanisms of action. They also exhibit a ceiling effect, with 10% to 20% of patients achievin... |
PMC4876147 | core_pubmed_pmc | A randomized, crossover pharmacodynamic study of immediate‐release omeprazole/sodium bicarbonate and delayed‐release lansoprazole in healthy adult volunteers | A randomized, crossover pharmacodynamic study of immediate‐release omeprazole/sodium bicarbonate and delayed‐release lansoprazole in healthy adult volunteers Abstract Abstract Proton pump inhibitors (PPIs) effectively block gastric acid secretion and are the treatment of choice for heartburn. PPIs differ, however, in o... |
PMC4582079 | core_pubmed_pmc | Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models | Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models Abstract Gerhard Levy started his investigations on the “Kinetics of Drug Action in Disease States” in the fall of 1980. The objective of his research was to study inter-individual variation in pharmacodynamics. To this en... |
PMC8048493 | core_pubmed_pmc | Evaluation Strategies for Triple‐Drug Combinations against Carbapenemase‐Producing Klebsiella Pneumoniae in an In Vitro Hollow‐Fiber Infection Model | Evaluation Strategies for Triple‐Drug Combinations against Carbapenemase‐Producing Klebsiella Pneumoniae in an In Vitro Hollow‐Fiber Infection Model Abstract Abstract Mounting antimicrobial resistance to carbapenemase‐producing Klebsiella pneumoniae (CPKP) highlights the need to optimize currently available treatment o... |
PMC9035501 | core_pubmed_pmc | Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study | Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study Abstract Abstract Eftozanermin alfa (eftoza), a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist, induces apoptosis in tumor cells by... |
PMC8617249 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic similarity between SAR341402 insulin aspart and Japan-approved NovoRapid in healthy Japanese subjects | Pharmacokinetic and pharmacodynamic similarity between SAR341402 insulin aspart and Japan-approved NovoRapid in healthy Japanese subjects Abstract Abstract This study compared the pharmacokinetic and glucodynamic profiles of biosimilar SAR341402 insulin aspart to Japan-approved insulin aspart (NovoRapid) in healthy Jap... |
PMC10961087 | core_pubmed_pmc | Optimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times | Optimal Once-Daily Busulfan Administration in Pediatric Patients: A Simulation-Based Investigation of Intravenous Infusion Times Abstract Abstract Purpose Pediatric patients receiving hematopoietic stem cell transplantation undergo regular administration of intravenous busulfan as a conditioning regimen. Once-daily reg... |
PMC3828004 | core_pubmed_pmc | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System | A Generic Integrated Physiologically based Whole-body Model of the Glucose-Insulin-Glucagon Regulatory System Abstract Abstract Models of glucose metabolism are a valuable tool for fundamental and applied medical research in diabetes. Use cases range from pharmaceutical target selection to automatic blood glucose contr... |
PMC10763002 | core_pubmed_pmc | Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes | Sex-biased gene expression and gene-regulatory networks of sex-biased adverse event drug targets and drug metabolism genes Abstract Abstract Background Previous pharmacovigilance studies and a retroactive review of cancer clinical trial studies identified that women were more likely to experience drug adverse events (i... |
PMC9176275 | core_pubmed_pmc | Finding the right fit: evaluation of short-read and long-read sequencing approaches to maximize the utility of clinical microbiome data | Finding the right fit: evaluation of short-read and long-read sequencing approaches to maximize the utility of clinical microbiome data Abstract Abstract A long-standing challenge in human microbiome research is achieving the taxonomic and functional resolution needed to generate testable hypotheses about the gut micro... |
PMC11700046 | core_pubmed_pmc | Safety and pharmacokinetics of vepdegestrant in Japanese patients with ER+ advanced breast cancer: a phase 1 study | Safety and pharmacokinetics of vepdegestrant in Japanese patients with ER+ advanced breast cancer: a phase 1 study Abstract Abstract Background Vepdegestrant (ARV-471) is an oral PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader. Methods This phase 1 study ( NCT05463952 ) investigated safety, pharm... |
PMC7826504 | core_pubmed_pmc | Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review | Pharmacogenetics of Direct Oral Anticoagulants: A Systematic Review Abstract Abstract Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants (DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics (transport and metabolism) is high, and could result from ... |
PMC4132447 | core_pubmed_pmc | A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer | A Phase I Study of Oral Paclitaxel with a Novel P-Glycoprotein Inhibitor, HM30181A, in Patients with Advanced Solid Cancer Abstract Purpose The purpose of this study is to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, and recommended phase II dose of an oral drug composed of paclitaxel and HM301... |
PMC10071678 | core_pubmed_pmc | Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study | Safety, pharmacokinetics, and pharmacodynamics of SHR7280, an oral gonadotropin-releasing hormone receptor antagonist, in healthy men: a randomized, double-blind, placebo-controlled phase 1 study Abstract Background Gonadotropin-releasing hormone (GnRH) antagonists are a promising therapeutic approach for treating horm... |
PMC12354395 | core_pubmed_pmc | Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling | Translational Pharmacokinetics of Icotrokinra, a Targeted Oral Peptide that Selectively Blocks Interleukin-23 Receptor and Inhibits Signaling Abstract Abstract Introduction Icotrokinra (formerly JNJ-77242113 or PN-21235) is a targeted oral peptide that selectively inhibits interleukin-23 receptor signaling. The studies... |
PMC12020277 | core_pubmed_pmc | Pharmacology and macrophage modulation of HPGDS inhibitor PK007 demonstrate reduced disease severity in DMD-affected muscles of the mdx mouse model | Pharmacology and macrophage modulation of HPGDS inhibitor PK007 demonstrate reduced disease severity in DMD-affected muscles of the mdx mouse model Abstract Abstract Background Duchenne Muscular Dystrophy (DMD) is an X-linked disease characterised by chronic inflammation, progressive muscle damage, and muscle loss. Typ... |
PMC9068679 | core_pubmed_pmc | Best Evidence-Based Dosing Recommendations for Dexmedetomidine for Premedication and Procedural Sedation in Pediatrics: Outcome of a Risk-Benefit Analysis By the Dutch Pediatric Formulary | Best Evidence-Based Dosing Recommendations for Dexmedetomidine for Premedication and Procedural Sedation in Pediatrics: Outcome of a Risk-Benefit Analysis By the Dutch Pediatric Formulary Abstract Abstract Background Dexmedetomidine is currently off-label for use in pediatric clinical care worldwide. Nevertheless, it i... |
PMC3674346 | core_pubmed_pmc | A caspase-3 ‘death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers | A caspase-3 ‘death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers Abstract Abstract Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trial... |
PMC8036504 | core_pubmed_pmc | Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review | Effect of Food and Dosing Regimen on Safety and Efficacy of Proton Pump Inhibitors Therapy—A Literature Review Abstract Abstract Proton pump inhibitors (PPIs) are the first-choice drugs used to prevent and treat acid-related diseases. However, a lack of satisfactory response to the standard PPI dose (“PPI failure”) is ... |
PMC7076440 | core_pubmed_pmc | New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC | New Preclinical Development of a c-Met Inhibitor and Its Combined Anti-Tumor Effect in c-Met-Amplified NSCLC Abstract c-Met is a receptor tyrosine kinase with no commercially available product despite being a pivotal target in cancer progression. Unlike other c-Met inhibitors that fail clinically, ABN401 is a newly syn... |
PMC11597315 | core_pubmed_pmc | Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Staphylococcus aureus Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction | Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Staphylococcus aureus Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction Abstract Abstract Background/Objectives: The work investigates the effect of the estragole c... |
PMC9691909 | core_pubmed_pmc | Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques | Single dose topical inserts containing tenofovir alafenamide fumarate and elvitegravir provide pre- and post-exposure protection against vaginal SHIV infection in macaques Abstract Summary Background Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women ... |
PMC12197952 | core_pubmed_pmc | Machine learning approach for personalized vancomycin steady-state trough concentration prediction: a superior approach over Bayesian population pharmacokinetic model | Machine learning approach for personalized vancomycin steady-state trough concentration prediction: a superior approach over Bayesian population pharmacokinetic model Abstract Introduction Appropriate vancomycin trough levels are crucial for ensuring therapeutic efficacy while minimizing toxicity. The aim of this study... |
PMC9641171 | core_pubmed_pmc | Anticoagulation in pediatric cancer–associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr | Anticoagulation in pediatric cancer–associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr Abstract Anticoagulant treatment of pediatric cancer–associated venous thromboembolism (VTE) has not been prospectively evaluated. Management of anticoagulation for cancer-associated VTE is often challenged by drug... |
PMC7842057 | core_pubmed_pmc | Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data | Predicting in vivo absorption of chloramphenicol in frogs using in vitro percutaneous absorption data Abstract Abstract Background Infectious disease, particularly the fungal disease chytridiomycosis (caused by Batrachochytrium dendrobatidis ), is a primary cause of amphibian declines and extinctions worldwide. The tra... |
PMC11880073 | core_pubmed_pmc | Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model | Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model Abstract Introduction The unbound brain-to-plasma partition coefficient (K p,uu,BBB ) is an essential parameter for predicting central nervous system (CNS) drug disposition using physiologically-... |
PMC6284181 | core_pubmed_pmc | Urinary tract infection with Klebsiella pneumoniae in Patients with Chronic Kidney Disease | Urinary tract infection with Klebsiella pneumoniae in Patients with Chronic Kidney Disease Abstract Study Motivation: After assessing electronic databases of medical scientific literature, we have observed that the interrelation between urinary tract infections (UTIs) and chronic kidney disease (CKD) is poorly studied,... |
PMC10543414 | core_pubmed_pmc | Healthcare Professionals and Undergraduate Students’ Knowledge Toward Drug-Food Interactions in the Eastern Region of Saudi Arabia | Healthcare Professionals and Undergraduate Students’ Knowledge Toward Drug-Food Interactions in the Eastern Region of Saudi Arabia Abstract Introduction Drug and Food Interactions (DFI) arise when particular nutrients in food interact with drugs when consumed concurrently, consequently resulting in alterations in the p... |
PMC12057362 | core_pubmed_pmc | Population pharmacokinetics and clinical assessment of linezolid in pediatric bacterial infections | Population pharmacokinetics and clinical assessment of linezolid in pediatric bacterial infections Abstract ABSTRACT The pharmacokinetic profile of linezolid still needs further definition, and insufficient or excessive exposure may lead to treatment failure or development of adverse events. Our study aimed to establis... |
PMC12141339 | core_pubmed_pmc | A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China | A sex-sensitive LC-MS/MS method with isotopic internal standard for prazosin bioequivalence: bridging precision medicine and generic drug policy in China Abstract Objective To develop a rapid, sensitive, and high-throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for prazosin quantification in ... |
PMC9290054 | core_pubmed_pmc | A Phase 1 study of the long‐acting anti‐IL‐5 monoclonal antibody GSK3511294 in patients with asthma | A Phase 1 study of the long‐acting anti‐IL‐5 monoclonal antibody GSK3511294 in patients with asthma Abstract Aims GSK3511294 is a humanized anti‐interleukin (IL)‐5 monoclonal antibody (mAb) engineered for extended half‐life and improved IL‐5 affinity versus other anti‐IL‐5 mAbs. This study examined its safety, tolerabi... |
PMC10039358 | core_pubmed_pmc | The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase | The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase Abstract Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a potential anti-flaviviral ... |
PMC4829939 | core_pubmed_pmc | Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA A receptor subtype | Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA A receptor subtype Abstract Abstract Agonists at the benzodiazepine-binding site of GABA A receptors (BDZs) enhance synaptic inhibition through four subtypes (α1, α2, α3 and α5) of GABA A receptors (GAB... |
PMC12299058 | core_pubmed_pmc | Mathematical Modeling of Andrographolide Therapy Effects and Immune Response in In Vivo Dynamics of SARS-CoV-2 Infection | Mathematical Modeling of Andrographolide Therapy Effects and Immune Response in In Vivo Dynamics of SARS-CoV-2 Infection Abstract Abstract This study explores the viral dynamics of SARS-CoV-2 infection within host cells by incorporating the pharmacological effects of andrographolide—a bioactive compound extracted from ... |
PMC10612060 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Analysis of the 3CL Protease Inhibitor Ensitrelvir in a SARS-CoV-2 Infection Mouse Model | Pharmacokinetic and Pharmacodynamic Analysis of the 3CL Protease Inhibitor Ensitrelvir in a SARS-CoV-2 Infection Mouse Model Abstract The small-molecule antiviral drug ensitrelvir targets the 3C-like protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study evaluated its inhibitory effect on ... |
PMC12500544 | core_pubmed_pmc | A case report of seizure worsening after perampanel add-on to oxcarbazepine: possible role of metabolic interaction and pharmacogenetics | A case report of seizure worsening after perampanel add-on to oxcarbazepine: possible role of metabolic interaction and pharmacogenetics Abstract Abstract Objective To investigate the factors contributing to increased seizure frequency in patients treated with a combination of oxcarbazepine (OXC) and perampanel. Method... |
PMC9745781 | core_pubmed_pmc | Stable HIV Reservoir Despite Prolonged Low-Dose Mycophenolate to Limit CD4+ T-cell Proliferation | Stable HIV Reservoir Despite Prolonged Low-Dose Mycophenolate to Limit CD4+ T-cell Proliferation Abstract Abstract Background The HIV reservoir of latently infected CD4+ T cells represents the barrier to cure. CD4+ T-cell proliferation is a mechanism that sustains the reservoir even during prolonged antiretroviral ther... |
PMC12383929 | core_pubmed_pmc | Quasi-3D Mechanistic Model for Predicting Eye Drop Distribution in the Human Tear Film | Quasi-3D Mechanistic Model for Predicting Eye Drop Distribution in the Human Tear Film Abstract Topical drug administration is a common method of delivering medications to the eye to treat various ocular conditions, including glaucoma, dry eye, and inflammation. Drug efficacy following topical administration, including... |
PMC7358594 | core_pubmed_pmc | Nuances to precision dosing strategies of targeted cancer medicines | Nuances to precision dosing strategies of targeted cancer medicines Abstract Abstract Selecting the dose of a targeted cancer medicine that is most appropriate for a specific individual is a rational approach to maximize therapeutic outcomes and minimize toxicity. There are many different options for optimizing the dos... |
PMC9193186 | core_pubmed_pmc | The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma | The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma Abstract Abstract Background and Aim Research has shown that green tea catechins may influence the activity of drug metabolizing enzymes and drug transpor... |
PMC10504078 | core_pubmed_pmc | RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts | RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts Abstract Elevated triglycerides and non-high-density lipoprotein cholesterol (HDL-C) are risk factors for atherosclerotic cardiovascular disease (ASCVD). ARO-ANG3 is an RNA interference therapy that targets angiop... |
PMC7033377 | core_pubmed_pmc | Pharmacometric models simulation using NONMEM, Berkeley Madonna and R | Pharmacometric models simulation using NONMEM, Berkeley Madonna and R Abstract Abstract In this tutorial, we introduce a differential equation simulation model for use in pharmacometrics involving NONMEM, Berkeley Madonna, and R. We report components of the simulation code and similarities/differences between software,... |
PMC4387202 | core_pubmed_pmc | Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics | Integrating dynamic mixed-effect modelling and penalized regression to explore genetic association with pharmacokinetics Abstract Supplemental Digital Content is available in the text. Keywords: high throughput analysis, nonlinear mixed-effect models, penalized regression, pharmacogenetics Abstract Context In a previou... |
PMC12118671 | core_pubmed_pmc | Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein | Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein Abstract In this work, the impact of physicochemical modifications on pharmacokinetics and in vivo targeting of a small molecule fibroblast activation protein inhibitor (F... |
PMC8373216 | core_pubmed_pmc | Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections | Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections Abstract ABSTRACT Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic fibrosis (CF) has a high probability of recurr... |
PMC11873266 | core_pubmed_pmc | In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeutics | In silico exploration of novel EGFR-targeting compounds: integrative molecular modeling, docking, pharmacokinetics, and MD simulations for advancing anti-cervical cancer therapeutics Abstract Abstract Cervical cancer continues to pose a significant health challenge, especially in resource-limited settings, highlighting... |
PMC12868300 | core_pubmed_pmc | Regulatory framework for polymer-based nanotherapeutics in clinical translation | Regulatory framework for polymer-based nanotherapeutics in clinical translation Abstract Polymer-based nanotherapeutics (PNs) have emerged as versatile drug delivery platforms offering controlled release, targeted delivery, and improved pharmacokinetics across therapeutic areas. However, their structural complexity and... |
PMC6476957 | core_pubmed_pmc | Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates | Treatment-Resistant Schizophrenia: Genetic and Neuroimaging Correlates Abstract Abstract Schizophrenia is a severe neuropsychiatric disorder that affects approximately 0.5–1% of the population. Response to antipsychotic therapy is highly variable, and it is not currently possible to predict those patients who will or w... |
PMC6590723 | core_pubmed_pmc | Fast and Sensitive Quantification of Δ 9 -Tetrahydrocannabinol and Its Main Oxidative Metabolites by Liquid Chromatography/Tandem Mass Spectrometry | Fast and Sensitive Quantification of Δ 9 -Tetrahydrocannabinol and Its Main Oxidative Metabolites by Liquid Chromatography/Tandem Mass Spectrometry Abstract Abstract Introduction: Few animal studies have evaluated the pharmacological effects of Δ 9 -tetrahydrocannabinol (THC) in relation to its pharmacokinetic properti... |
PMC11137767 | core_pubmed_pmc | Systematic exploration of network pharmacology, in silico modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome | Systematic exploration of network pharmacology, in silico modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome Abstract Abstract Aim: This study seeks to explore the possibility of using vitamin E to alleviate the symptoms of polycystic ovarian syndrome (PCOS). Methods: Various computatio... |
PMC10873176 | core_pubmed_pmc | Defining Optimal Doses of Liposomal Amphotericin B Against Candida auris: Data From an In Vitro Pharmacokinetic/Pharmacodynamic Model | Defining Optimal Doses of Liposomal Amphotericin B Against Candida auris: Data From an In Vitro Pharmacokinetic/Pharmacodynamic Model Abstract Abstract Background Candida auris isolates exhibit elevated amphotericin B (AMB) minimum inhibitory concentrations (MICs). As liposomal AMB (L-AMB) can be safely administered at... |
PMC9441672 | core_pubmed_pmc | Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential | Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential Abstract Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause of mortality worldwide, and the number of cancer patie... |
PMC8078337 | core_pubmed_pmc | Hemodynamic Effects of an Increased Midodrine Dosing Frequency | Hemodynamic Effects of an Increased Midodrine Dosing Frequency Abstract Objectives: In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours. One possible re... |
PMC12772275 | core_pubmed_pmc | Eravacycline pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium abscessus lung disease | Eravacycline pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium abscessus lung disease Abstract ABSTRACT Treatment of Mycobacterium abscessus (MAB) pulmonary diseases is challenging due to intrinsic resistance to many antibiotics and requires prolonged intravenous therapy with drugs tha... |
PMC7351850 | core_pubmed_pmc | A drug–drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers | A drug–drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers Abstract Purpose Peficitinib is an oral pan-Janus kinase inhibitor for the treatment of rheumatoid arthritis. Co-administration of peficitinib with metformin, a type 2 diabetes th... |
PMC10951637 | core_pubmed_pmc | An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits | An imbalanced GLP-1R/GIPR co-agonist peptide with a site-specific N-terminal PEGylation to maximize metabolic benefits Abstract Summary Glycemic and body weight control gained from GLP-1R agonists remains an unmet need for diabetes and obesity treatment, leading to the development of GLP-1R/GIPR co-agonists. An imbalan... |
PMC4204849 | core_pubmed_pmc | Lifespan Based Pharmacokinetic-Pharmacodynamic Model of Tumor Growth Inhibition by Anticancer Therapeutics | Lifespan Based Pharmacokinetic-Pharmacodynamic Model of Tumor Growth Inhibition by Anticancer Therapeutics Abstract Accurate prediction of tumor growth is critical in modeling the effects of anti-tumor agents. Popular models of tumor growth inhibition (TGI) generally offer empirical description of tumor growth. We prop... |
PMC10675232 | core_pubmed_pmc | Pharmacokinetics in Pharmacometabolomics: Towards Personalized Medication | Pharmacokinetics in Pharmacometabolomics: Towards Personalized Medication Abstract Abstract Indiscriminate drug administration may lead to drug therapy results with varying effects on patients, and the proposal of personalized medication can help patients to receive effective drug therapy. Conventional ways of personal... |
PMC8576179 | core_pubmed_pmc | Monitoring Intra-cellular Tacrolimus Concentrations in Solid Organ Transplantation: Use of Peripheral Blood Mononuclear Cells and Graft Biopsy Tissue | Monitoring Intra-cellular Tacrolimus Concentrations in Solid Organ Transplantation: Use of Peripheral Blood Mononuclear Cells and Graft Biopsy Tissue Abstract Tacrolimus is an essential immunosuppressant for the prevention of rejection in solid organ transplantation. Its low therapeutic index and high pharmacokinetic v... |
PMC11977279 | core_pubmed_pmc | Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma | Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma Abstract The pharmacokinetics of LXT-101 sustained-release suspension, an anti-prostate cancer polypeptide, were studied on beagle dogs usin... |
PMC11112049 | core_pubmed_pmc | A highly sensitive stem-loop RT-qPCR method to study siRNA intracellular pharmacokinetics and pharmacodynamics | A highly sensitive stem-loop RT-qPCR method to study siRNA intracellular pharmacokinetics and pharmacodynamics Abstract Abstract Small interfering RNA (siRNA) is a powerful tool for sequence-specific silencing of disease-related genes. In this study, we established and validated a stem-loop reverse transcription-quanti... |
PMC9645288 | core_pubmed_pmc | An update on recently approved long-acting injectable second-generation antipsychotics: Knowns and unknowns regarding their use | An update on recently approved long-acting injectable second-generation antipsychotics: Knowns and unknowns regarding their use Abstract There are now 9 available FDA-approved second-generation long-acting injectable antipsychotics including aripiprazole (3), olanzapine (1), paliperidone (3), and risperidone (2). These... |
PMC5005638 | core_pubmed_pmc | Postoperative Bleeding After Administration of a Single Dose of Rivaroxaban to a Patient Receiving Antiretroviral Therapy | Postoperative Bleeding After Administration of a Single Dose of Rivaroxaban to a Patient Receiving Antiretroviral Therapy Abstract Abstract A 62-year-old man was admitted to hospital for elective revision of a left total hip arthroplasty. His history was significant for human immunodeficiency virus (HIV) infection for ... |
PMC5863685 | core_pubmed_pmc | Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain | Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain Abstract Abstract Mannosylated polymeric nanoparticles (NPs) enable improvement of brain bioavailability and reduction of dosing due to efficient drug delivery at the target site. Mannose receptors are present on the surface of macroph... |
PMC5442689 | core_pubmed_pmc | Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs | Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs Abstract Background Medication effect is the sum of its drug, placebo, and drug*placebo interaction effects. It is conceivable that the interaction effect involves modulating drug bioavailability; it was previously obser... |
PMC4582734 | core_pubmed_pmc | Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children | Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children Abstract Abstract Background Anti-malarial chemoprevention with dihydroartemisinin-piperaquine (DHA/PQ) is a promising tool for malaria control, but its eff... |
PMC6050476 | core_pubmed_pmc | Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative | Pre-clinical Pharmacokinetic and Metabolomic Analyses of Isorhapontigenin, a Dietary Resveratrol Derivative Abstract Abstract Background: Isorhapontigenin ( trans –3,5,4′-trihydroxy–3′–methoxystilbene, ISO), a dietary resveratrol ( trans –3,5,4′–trihydroxystilbene) derivative, possesses various health-promoting activit... |
PMC3776988 | core_pubmed_pmc | Phase I–II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma | Phase I–II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma Abstract Abstract Background: This phase I–II trial compared plitidepsin 1-h infusion alone or combined with dacarbazine (DTIC) 1-h infusion as front-line therapy for advanced melanoma. Methods: The recommended dose (RD) for pli... |
PMC12242990 | core_pubmed_pmc | The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition | The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition Abstract Abstract Diet is a complex exposure that affects health across the lifespan. Objective biomarkers that can reliably reflect intake of nutrients, foods, and dietary patterns wi... |
PMC10125376 | core_pubmed_pmc | Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist | Unanticipated Characteristics of a Selective, Potent Neuromedin-U Receptor 2 Agonist Abstract Abstract Neuromedin-U (NMU) mediates several physiological functions via its two cognate receptors, NMUR1 and NMUR2. Disentangling the individual roles of each receptor has largely been undertaken through the use of transgenic... |
PMC8251571 | core_pubmed_pmc | Pharmacokinetic modeling and simulation support for age‐ and weight‐adjusted dosing of dabigatran etexilate in children with venous thromboembolism | Pharmacokinetic modeling and simulation support for age‐ and weight‐adjusted dosing of dabigatran etexilate in children with venous thromboembolism Abstract Abstract Background Dabigatran etexilate (DE), a direct oral thrombin inhibitor, has been evaluated in children with venous thromboembolism (VTE) using oral soluti... |
PMC10673279 | core_pubmed_pmc | Metabolic Transformation of Gentiopicrin, a Liver Protective Active Ingredient, Based on Intestinal Bacteria | Metabolic Transformation of Gentiopicrin, a Liver Protective Active Ingredient, Based on Intestinal Bacteria Abstract Gentiopicrin, the main component of the famous Chinese patent medicine Long Dan Xie Gan Wan, has the characteristics of fast absorption in vivo and low bioavailability. Intestinal bacteria play an impor... |
PMC4417944 | core_pubmed_pmc | The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results from a Phase III, Randomized, Placebo-Controlled Trial (PALACE 1) | The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results from a Phase III, Randomized, Placebo-Controlled Trial (PALACE 1) Abstract Abstract Apremilast, an oral phosphodiesterase 4 inhibitor, ... |
PMC8576103 | core_pubmed_pmc | An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design | An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design Abstract Abstract Background Sorbitan monostearate is a surfactant used in the food industry. It was proved as a penetration enhancer to metformin HCl via a... |
PMC6061075 | core_pubmed_pmc | Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models | Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models Abstract Drug–target binding kinetics (as determined by association and dissociation rate constants, k on and k off ) can be an important determinant of the kinetics of drug action. However... |
PMC11859527 | core_pubmed_pmc | Clinical Pharmacology of Bulevirtide: Focus on Known and Potential Drug–Drug Interactions | Clinical Pharmacology of Bulevirtide: Focus on Known and Potential Drug–Drug Interactions Abstract Background: Hepatitis D virus (HDV) is a defective virus requiring co-infection with hepatitis B virus (HBV) to replicate, occurring in 5% of HBV+ patients. Bulevirtide (BLV) is now the first-in-class specific anti-HDV ag... |
PMC6416024 | core_pubmed_pmc | Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria | Pharmacokinetic-pharmacodynamic analysis of ciprofloxacin in elderly Chinese patients with lower respiratory tract infections caused by Gram-negative bacteria Abstract Abstract Background: Ciprofloxacin is usually used in the treatment of lower respiratory tract infections (LRTIs). Recent studies abroad have shown cipr... |
PMC11263822 | core_pubmed_pmc | Effects of Body Mass Index and Body Weight on Plasma Concentration of Ticagrelor and Platelet Aggregation Rate in Patients with Unstable Angina in a Chinese Han Population | Effects of Body Mass Index and Body Weight on Plasma Concentration of Ticagrelor and Platelet Aggregation Rate in Patients with Unstable Angina in a Chinese Han Population Abstract Abstract Background: The aim of this study was to investigate the impact of body mass index (BMI) and body weight on the concentrations of ... |
PMC4467241 | core_pubmed_pmc | The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis | The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis Abstract Abstract Apremilast is a novel agent for the treatment of inflammatory based autoimmune disorders. The objective of this study was to assess the pharmacokinetic effects... |
PMC12159124 | core_pubmed_pmc | Scoping Review of Paediatric Population Pharmacokinetic Models of Morphine | Scoping Review of Paediatric Population Pharmacokinetic Models of Morphine Abstract Objective and Purpose This scoping review aimed to summarise all available population pharmacokinetic models of morphine and its metabolites (morphine-3-glucoronide [M3G], morphine-6-glucoronide [M6G]) in children and describe how morph... |
PMC10875102 | core_pubmed_pmc | Exploratory focused pharmacogenetic testing reveals novel markers associated with risperidone pharmacokinetics in Saudi children with autism | Exploratory focused pharmacogenetic testing reveals novel markers associated with risperidone pharmacokinetics in Saudi children with autism Abstract Background: Autism spectrum disorders (ASDs) encompass a broad range of phenotypes characterized by diverse neurological alterations. Genomic studies have revealed consid... |
PMC3907813 | core_pubmed_pmc | Evaluation of Epirubicin in Thermogelling and Bioadhesive Liquid and Solid Suppository Formulations for Rectal Administration | Evaluation of Epirubicin in Thermogelling and Bioadhesive Liquid and Solid Suppository Formulations for Rectal Administration Abstract Abstract Temperature sensitive Pluronic (Plu) and pH-sensitive polyacrylic acid (PAA) were successfully mixed in different ratios to form in situ gelling formulations for colon cancer t... |
PMC11096368 | core_pubmed_pmc | Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region | Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal d... |
PMC5810080 | core_pubmed_pmc | Evaluation of Teaching Clinical Pharmacology of Antiarrhythmic Drugs to First-Year MBBS Students Through Worksheet-Based Small-Group Discussion | Evaluation of Teaching Clinical Pharmacology of Antiarrhythmic Drugs to First-Year MBBS Students Through Worksheet-Based Small-Group Discussion Abstract Cardiac arrhythmias are a major cause of morbidity and mortality across the world. Learning the science behind the use of antiarrhythmic drugs is essential for all med... |
PMC5109405 | core_pubmed_pmc | Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers | Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers Abstract For patients with locally advanced rectal cancer (LARC) treated with preoperation chemoradiation (pCRT), identifying differentially expressed (DE) genes between non-responders and responders is ... |
PMC5923419 | core_pubmed_pmc | Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats | Pharmacokinetic and Tissue Distribution of Fucoidan from Fucus vesiculosus after Oral Administration to Rats Abstract Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the... |
PMC3787571 | core_pubmed_pmc | Pharmacokinetics and Bioequivalence Evaluation of Cyclobenzaprine Tablets | Pharmacokinetics and Bioequivalence Evaluation of Cyclobenzaprine Tablets Abstract Abstract The purpose of this study was to investigate cyclobenzaprine pharmacokinetics and to evaluate bioequivalence between two different tablet formulations containing the drug. An open, randomized, crossover, single-dose, two-period,... |
PMC11721935 | core_pubmed_pmc | The phase I/II eNRGy trial: Zenocutuzumab in patients with cancers harboring NRG1 gene fusions | The phase I/II eNRGy trial: Zenocutuzumab in patients with cancers harboring NRG1 gene fusions Abstract Neuregulin 1 ( NRG1 ) fusions are oncogenic drivers that have been detected in non-small-cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC) and other solid tumors. NRG1 fusions are rare, occurring in l... |
PMC9399588 | core_pubmed_pmc | Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults | Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults Abstract Purpose Fedratinib is an orally administered Janus kinase (JAK) 2–selective inhibitor for the treatment of adult patients with intermediate-2 or high-risk primary or secondary myelofibrosis. In vitro, fedratinib is p... |
PMC5564600 | core_pubmed_pmc | Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors | Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors Abstract Multiple therapeutic agents have been developed to target the phosphatidylinositol 3-kinase (PI3K) signaling pathway, which is frequently dysregul... |
PMC12628325 | core_pubmed_pmc | Structural Instability of Human Serum Albumin during Microparticles Synthesis | Structural Instability of Human Serum Albumin during Microparticles Synthesis Abstract Abstract Human serum albumin, the most abundant plasma protein, plays vital roles in maintaining oncotic pressure, modulates drugs pharmacokinetics and pharmacodynamics, and features antioxidant and enzyme-like properties. This prote... |
PMC6749432 | core_pubmed_pmc | Simultaneous Quantification of Four Phenylethanoid Glycosides in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study of Acanthus Ilicifolius Herb | Simultaneous Quantification of Four Phenylethanoid Glycosides in Rat Plasma by UPLC-MS/MS and Its Application to a Pharmacokinetic Study of Acanthus Ilicifolius Herb Abstract Abstract Acanthus ilicifolius herb (AIH), the dry plant of Acanthus ilicifolius L., has long been used as a folk medicine for treating acute and ... |
PMC8349197 | core_pubmed_pmc | Improved Anti-Triple Negative Breast Cancer Effects of Docetaxel by RGD-Modified Lipid-Core Micelles | Improved Anti-Triple Negative Breast Cancer Effects of Docetaxel by RGD-Modified Lipid-Core Micelles Abstract Purpose A novel RGD-modified PEGylated lipid-core micelle delivery system was designed to improve the anti-cancer effect of docetaxel on triple negative breast cancer (TNBC). Methods The tumor-targeted lipid-co... |
PMC9795017 | core_pubmed_pmc | Characterization of the acetylation of cyclooxygenase-isozymes and targeted lipidomics of eicosanoids in serum and colon cancer cells by the new aspirin formulation IP1867B versus aspirin in vitro | Characterization of the acetylation of cyclooxygenase-isozymes and targeted lipidomics of eicosanoids in serum and colon cancer cells by the new aspirin formulation IP1867B versus aspirin in vitro Abstract Abstract Background: Aspirin(acetylsalicylic acid, ASA) is recommended for the secondary prevention of atherothrom... |
PMC9284531 | core_pubmed_pmc | Core shell stationary phase for a novel separation of some COVID-19 used drugs by UPLC-MS/MS Method: Study of grapefruit consumption impact on their pharmacokinetics in rats | Core shell stationary phase for a novel separation of some COVID-19 used drugs by UPLC-MS/MS Method: Study of grapefruit consumption impact on their pharmacokinetics in rats Abstract Abstract A sensitive and selective UPLC-MS/MS method was developed for the synchronized determination of four drugs used in severe acute ... |
PMC10130689 | core_pubmed_pmc | Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease | Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease Abstract Abstract Purpose Complement C1q, the initiating molecule of the classical complement cascade, is involved in synapse elimination and neuronal loss in neurodegenerative diseases including glaucoma. Here we report an... |
PMC7126499 | core_pubmed_pmc | Medicinal plants of the genus Betula —Traditional uses and a phytochemical–pharmacological review | Medicinal plants of the genus Betula —Traditional uses and a phytochemical–pharmacological review Abstract Abstract Ethnopharmacological relevance Trees and shrubs of the genus Betula (Betulaceae) inhabit various ecosystems in temperate and boreal climate zones of the northern hemisphere. The healing properties of Betu... |
PMC10976394 | core_pubmed_pmc | EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir | EIDD-1931 Treatment Tweaks CYP3A4 and CYP2C8 in Arthritic Rats to Expedite Drug Interaction: Implication in Oral Therapy of Molnupiravir Abstract EIDD-1931 is the active form of molnupiravir, an orally effective drug approved by the United States Food and Drug Administration (USFDA) against COVID-19. Pharmacokinetic al... |
PMC8210975 | core_pubmed_pmc | Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell–Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial | Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell–Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial Abstract PURPOSE Glofitamab is a T-cell–engaging bispecific antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and mo... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.