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PMC8878862 | core_pubmed_pmc | The Role of Intra-Patient Variability of Tacrolimus Drug Concentrations in Solid Organ Transplantation: A Focus on Liver, Heart, Lung and Pancreas | The Role of Intra-Patient Variability of Tacrolimus Drug Concentrations in Solid Organ Transplantation: A Focus on Liver, Heart, Lung and Pancreas Abstract Abstract Tacrolimus, the keystone immunosuppressive drug administered after solid organ transplantation, presents a narrow therapeutic index and wide inter- and int... |
PMC6337116 | core_pubmed_pmc | Herb–Drug Interaction Potential of Anti-Borreliae Effective Extracts from Uncaria tomentosa (Samento) and Otoba parvifolia (Banderol) Assessed In Vitro | Herb–Drug Interaction Potential of Anti-Borreliae Effective Extracts from Uncaria tomentosa (Samento) and Otoba parvifolia (Banderol) Assessed In Vitro Abstract Samento (extract from Uncaria tomentosa ) and Banderol (extract from Otoba parvifolia ) have been demonstrated to have anti-inflammatory and antimicrobial prop... |
PMC3157330 | core_pubmed_pmc | In vitro and in vivo evaluation of folate receptor-targeting amphiphilic copolymer-modified liposomes loaded with docetaxel | In vitro and in vivo evaluation of folate receptor-targeting amphiphilic copolymer-modified liposomes loaded with docetaxel Abstract Abstract Background: The purpose of this study was to develop folate-poly (PEG-cyanoacrylate-co-cholesteryl cyanoacrylate) (FA-PEG-PCHL)-modified freeze-dried liposomes for targeted chemo... |
PMC7713860 | core_pubmed_pmc | A semi-compartmental model describing the pharmacokinetic-pharmacodynamic relationship | A semi-compartmental model describing the pharmacokinetic-pharmacodynamic relationship Abstract Abstract Frequently, we encounter the phenomenon of hysteresis in kinetic-dynamic modeling. The hysteresis loop in the concentration-effect curve suggests a time discrepancy caused by various pharmacokinetic and pharmacodyna... |
PMC9505004 | core_pubmed_pmc | Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment | Novel αO-conotoxin GeXIVA[1,2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment Abstract Abstract αO-conotoxin GeXIVA was isolated in our laboratory from Conus generalis, a snail native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered analgesic targeti... |
PMC12293381 | core_pubmed_pmc | Valorization of a Natural Compound Library in Exploring Potential Marburg Virus VP35 Cofactor Inhibitors via an In Silico Drug Discovery Strategy | Valorization of a Natural Compound Library in Exploring Potential Marburg Virus VP35 Cofactor Inhibitors via an In Silico Drug Discovery Strategy Abstract This study focuses on exploring potential inhibitors of the Marburg virus interferon inhibitory domain protein (MARV-VP35), which is responsible for immune evasion a... |
PMC8398280 | core_pubmed_pmc | Pharmacokinetic Investigation of Commercially Available Edible Marijuana Products in Humans: Potential Influence of Body Composition and Influence on Glucose Control | Pharmacokinetic Investigation of Commercially Available Edible Marijuana Products in Humans: Potential Influence of Body Composition and Influence on Glucose Control Abstract The purpose of the study was to describe and compare the pharmacokinetics of five commercial edible marijuana products, determine the influence o... |
PMC7577045 | core_pubmed_pmc | Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease | Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease Abstract Abstract Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson’s disease (PD). This study was designed to formulate borneol and lac... |
PMC9305164 | core_pubmed_pmc | PET as a Translational Tool in Drug Development for Neuroscience Compounds | PET as a Translational Tool in Drug Development for Neuroscience Compounds Abstract Abstract In central nervous system drug discovery programs, early development of new chemical entities (NCEs) requires a multidisciplinary strategy and a translational approach to obtain proof of distribution, proof of occupancy, and pr... |
PMC12751760 | core_pubmed_pmc | A drug-drug interaction study to evaluate the effects of strong CYP3A4 inducer on the pharmacokinetics of segesterone acetate and ethinyl estradiol in a contraceptive vaginal system | A drug-drug interaction study to evaluate the effects of strong CYP3A4 inducer on the pharmacokinetics of segesterone acetate and ethinyl estradiol in a contraceptive vaginal system Abstract Abstract Background In 2018, the US FDA approved a long-acting contraceptive vaginal system (CVS) releasing a new progestin, sege... |
PMC10693274 | core_pubmed_pmc | Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect | Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect Abstract Purpose To develop an UPLC-MS/MS method for the quantitative analysis of pentoxifylline in beagle dog plasma and apply it to a pharmacokinetic study of food... |
PMC11678900 | core_pubmed_pmc | The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies | The Study of Ropivacaine Pharmacokinetics in a Clinical Setting: A Critical Scoping Review from the Perspective of Analytical Methodologies Abstract Abstract Ropivacaine, a widely used regional anesthetic also used for pain management, has been increasingly used in recent years due to its increased efficacy and improve... |
PMC9619075 | core_pubmed_pmc | Potential interactions between antineoplastic agents and medicines used to treat Covid-19 | Potential interactions between antineoplastic agents and medicines used to treat Covid-19 Abstract Introduction Cancer patients with Covid-19 are exposed to treatment combinations that can potentially result in interactions that adversely affect patient outcomes. This study aimed to identify potential drug–drug interac... |
PMC7537958 | core_pubmed_pmc | The Complex Management of Atrial Fibrillation and Cancer in the COVID-19 Era: Drug Interactions, Thromboembolic Risk, and Proarrhythmia | The Complex Management of Atrial Fibrillation and Cancer in the COVID-19 Era: Drug Interactions, Thromboembolic Risk, and Proarrhythmia Abstract Purpose of Review Cardiotoxicity by anticancer agents has emerged as a multifaceted issue and is expected to affect both mortality and morbidity. This review summarizes clinic... |
PMC7246325 | core_pubmed_pmc | Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors | Effects of Apatinib on the Pharmacokinetics of Nifedipine and Warfarin in Patients with Advanced Solid Tumors Abstract Background and Purpose Apatinib is a small-molecule tyrosine kinase inhibitor for the treatment of recurrent or progressive advanced-stage gastric adenocarcinoma or gastroesophageal junction cancer. Th... |
PMC7097915 | core_pubmed_pmc | Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography | Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography Abstract Abstract Rationale: In vivo molecular imaging in preclinical animal models is a tool of choice for understanding the pathophysiological mechanisms involved in canc... |
PMC10551947 | core_pubmed_pmc | Correlation of drug exposure and bacterial susceptibility with treatment response for Mycobacterium avium complex lung disease: protocol for a prospective observational cohort study | Correlation of drug exposure and bacterial susceptibility with treatment response for Mycobacterium avium complex lung disease: protocol for a prospective observational cohort study Abstract Abstract Introduction The burden of Mycobacterium avium complex (MAC) lung disease is increasing globally and treatment outcome i... |
PMC7808980 | core_pubmed_pmc | Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain | Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain Abstract Background and Objective Ampreloxetine is a novel norepinephrine reuptake inhibitor in development for the treatment of symptomatic neurogenic ... |
PMC3528770 | core_pubmed_pmc | Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy | Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy Abstract Apolipoprotein A-I (Apo A-I) is a major component of high density lipoproteins (HDL) that transport cholesterol in circulation. We have constructed an expression plasmid encoding a chime... |
PMC11812929 | core_pubmed_pmc | Pharmacometric and statistical considerations for dose optimization | Pharmacometric and statistical considerations for dose optimization Abstract Abstract The probability of target attainment (PTA) is a common metric in drug dose optimization, but it requires a specific known target concentration threshold. Such target thresholds are not always available for some treatments, and patient... |
PMC10452662 | core_pubmed_pmc | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA | ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA Abstract Abstract The COVID-19 pandemic caused much illness, many deaths, and profound disruption to society. The production of ‘safe and effective’ vaccines was a key public health target. Sadly, unprecedented high rates of adverse e... |
PMC12325258 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic integration and resistance analysis of cefquinome against Streptococcus uberis in vitro dynamic model | Pharmacokinetic and pharmacodynamic integration and resistance analysis of cefquinome against Streptococcus uberis in vitro dynamic model Abstract Abstract Introduction Streptococcus uberis (S. uberis) is a major pathogen that causes acute clinical mastitis and its recurrent episodes in dairy cows. Methods In this stud... |
PMC6862531 | core_pubmed_pmc | Pharmacokinetics and exploratory efficacy biomarkers of bococizumab, an anti-PCSK9 monoclonal antibody, in hypercholesterolemic Japanese subjects | Pharmacokinetics and exploratory efficacy biomarkers of bococizumab, an anti-PCSK9 monoclonal antibody, in hypercholesterolemic Japanese subjects Abstract Abstract Objective: Bococizumab, a monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, has been shown to reduce low-density lipoprotein chol... |
PMC6699285 | core_pubmed_pmc | A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats | A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats Abstract Abstract A high-throughput HPLC-MS/MS method was developed and validated for the determination of four antihypertensive drugs includi... |
PMC5032874 | core_pubmed_pmc | Factors Influencing the Relationship Between the Dose of Amlodipine Required for Blood Pressure Control and Change in Blood Pressure in Hypertensive Cats | Factors Influencing the Relationship Between the Dose of Amlodipine Required for Blood Pressure Control and Change in Blood Pressure in Hypertensive Cats Abstract Background Hypertension is a common problem in elderly cats. In most cats, systolic blood pressure (SBP) of <160 mmHg is achieved in response to amlodipine b... |
PMC6496041 | core_pubmed_pmc | Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations | Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations Abstract Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patie... |
PMC6804364 | core_pubmed_pmc | Current Advance in Thrombopoietin Receptor Agonists in the Management of Thrombocytopenia Associated With Chronic Liver Disease: Focus on Avatrombopag | Current Advance in Thrombopoietin Receptor Agonists in the Management of Thrombocytopenia Associated With Chronic Liver Disease: Focus on Avatrombopag Abstract Chronic liver disease (CLD) is a condition that progresses over time toward advanced disease state which is known as liver cirrhosis. Liver cirrhosis leads to d... |
PMC10971055 | core_pubmed_pmc | Design, Synthesis, Anti-Inflammatory Activity, DFT Modeling and Docking Study of New Ibuprofen Derivatives | Design, Synthesis, Anti-Inflammatory Activity, DFT Modeling and Docking Study of New Ibuprofen Derivatives Abstract A new ibuprofen derivative, ( E )-2-(4-isobutylphenyl)-N′-(4-oxopentan-2-ylidene) propane hydrazide (IA), was synthesized, along with its metal complexes with Co, Cu, Ni, Gd, and Sm, to investigate their ... |
PMC6788879 | core_pubmed_pmc | Development and validation of a methotrexate adherence assay | Development and validation of a methotrexate adherence assay Abstract Abstract Background The first-line therapy for rheumatoid arthritis (RA) is weekly oral methotrexate (MTX) at low dosages (7.5–25 mg/week). However, ~40% of patients are non-adherent which may explain why some do not respond and need to start more ex... |
PMC11393540 | core_pubmed_pmc | CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib | CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib Abstract Abstract Purpose: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony - stimulating factor 1 ( CSF1 ) gene and overexpression of the C... |
PMC10175413 | core_pubmed_pmc | Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer | Tamoxifen pharmacokinetics and pharmacodynamics in older patients with non-metastatic breast cancer Abstract Background We aimed to study the pharmacokinetics and -dynamics of tamoxifen in older women with non-metastatic breast cancer. Methods Data for this analysis were derived from the CYPTAM study (NTR1509) database... |
PMC9124350 | core_pubmed_pmc | Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids | Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids Abstract Abstract Intraoperative targeting of the analgesic effect still lacks an optimal solution. Opioids are currently the main drug used to achieve antinociception, and although underdosing ca... |
PMC9221057 | core_pubmed_pmc | Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio | Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio Abstract Abstract The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/car... |
PMC12006280 | core_pubmed_pmc | Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Cefiderocol in Chinese Healthy Subjects | Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Cefiderocol in Chinese Healthy Subjects Abstract Abstract Introduction We aim to evaluate the safety and pharmacokinetic (PK) properties of cefiderocol in Chinese participants, following single and subsequent multiple administrations of 2 g ... |
PMC7999883 | core_pubmed_pmc | Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats | Saccharomyces cerevisiae Cell Wall-Based Adsorbent Reduces Aflatoxin B1 Absorption in Rats Abstract Mycotoxins are naturally occurring toxins that can affect livestock health and performance upon consumption of contaminated feedstuffs. To mitigate the negative effects of mycotoxins, sequestering agents, adsorbents, or ... |
PMC8423491 | core_pubmed_pmc | Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis | Wuzhi Capsule Dosage Affects Tacrolimus Elimination in Adult Kidney Transplant Recipients, as Determined by a Population Pharmacokinetics Analysis Abstract Abstract Purpose In this study, we aimed to establish a tacrolimus population pharmacokinetic model and better understand the drug-drug interaction between Wuzhi ca... |
PMC9630157 | core_pubmed_pmc | Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial | Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial Abstract Summary Background Children with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aime... |
PMC8987933 | core_pubmed_pmc | Effect of Green Tea Extract and Soy Isoflavones on the Pharmacokinetics of Rosuvastatin in Healthy Volunteers | Effect of Green Tea Extract and Soy Isoflavones on the Pharmacokinetics of Rosuvastatin in Healthy Volunteers Abstract Abstract Background and Aim Green tea and soy products are extensively consumed in daily life. Research has shown that green tea catechins and soy isoflavones may influence the activity of drug metabol... |
PMC4758302 | core_pubmed_pmc | Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide | Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide Abstract Purpose The current study aims to evaluate a porous silicon-based drug delivery system meant for sustained delivery of dexamethasone (Dex) to the vitreous and retina. Methods Dexamethasone was grafted covalent... |
PMC3160560 | core_pubmed_pmc | Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib | Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib Abstract Summary Objectives Danusertib is a serine/threonine kinase inhibitor of multiple kinases, including aurora-A, B, and C. This explorative study aims to identify possible relationships between ... |
PMC4713870 | core_pubmed_pmc | Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model | Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-Gestational Fetal Surgery: A Maternal-Fetal Sheep Model Abstract Background Measuring fetal drug concentrations is extremely difficult in humans. We conducted a study in pregnant sheep to simultaneously describe maternal and fetal concentrat... |
PMC7003660 | core_pubmed_pmc | Different Routes of Proton Pumps Inhibitors Co-Administration have Significant Impact on Mycophenolate Acid (MPA) Serum Levels in Heart Transplant Recipients | Different Routes of Proton Pumps Inhibitors Co-Administration have Significant Impact on Mycophenolate Acid (MPA) Serum Levels in Heart Transplant Recipients Abstract Background Antiproliferative drugs including mycophenolate mofetil (MMF) are widely accepted part of an immunosuppressive therapy following heart transpl... |
PMC8105861 | core_pubmed_pmc | Aerosol delivery via noninvasive ventilation: role of models and bioanalysis | Aerosol delivery via noninvasive ventilation: role of models and bioanalysis Abstract Non-invasive ventilation (NIV) is external support for respiration to assist breathing in case of respiratory failure (either hypercapnic or hypoxemic) without patient intubation. Nowadays, medicated aerosols are normally delivered to... |
PMC4394428 | core_pubmed_pmc | Pharmacogenetics Informed Decision Making in Adolescent Psychiatric Treatment: A Clinical Case Report | Pharmacogenetics Informed Decision Making in Adolescent Psychiatric Treatment: A Clinical Case Report Abstract Abstract Advances made in genetic testing and tools applied to pharmacogenetics are increasingly being used to inform clinicians in fields such as oncology, hematology, diabetes (endocrinology), cardiology and... |
PMC6710501 | core_pubmed_pmc | Effect of hepatic impairment on the pharmacokinetics of vilaprisan: An open‐label, single‐dose, parallel‐group study | Effect of hepatic impairment on the pharmacokinetics of vilaprisan: An open‐label, single‐dose, parallel‐group study Abstract Aims The study objective was to evaluate the pharmacokinetics of the selective progesterone receptor modulator vilaprisan in participants with hepatic impairment. Additionally, the safety and to... |
PMC11150668 | core_pubmed_pmc | Small pouches, but high nicotine doses—nicotine delivery and acute effects after use of tobacco-free nicotine pouches | Small pouches, but high nicotine doses—nicotine delivery and acute effects after use of tobacco-free nicotine pouches Abstract Abstract Tobacco-free nicotine pouches are new nicotine products for oral consumption. They can contain very high nicotine amounts that have not been addressed with clinical studies yet. Thus, ... |
PMC10222242 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation | Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation Abstract The bioequivalence of bempedoic acid oral suspension and commercial immediate release (IR) tablet formulations were assessed using a physiologic... |
PMC9207402 | core_pubmed_pmc | Predicted Vancomycin Dosage Requirement in Patients With Hematological Malignancies and Dosage Dynamic Adjustment | Predicted Vancomycin Dosage Requirement in Patients With Hematological Malignancies and Dosage Dynamic Adjustment Abstract Purpose: The purpose of this study was 1) to predict the requisite vancomycin daily dose ( D van ) used in the target patients suffering from both bacterial infection and hematological malignancies... |
PMC6550417 | core_pubmed_pmc | Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Côte d’Ivoire | Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Côte d’Ivoire Abstract Background A single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB),... |
PMC10747907 | core_pubmed_pmc | Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design | Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design Abstract Physiologically based pharmacokinetic (PBPK) models of skin absorption are a powerful resource for estimating drug delivery and chemical risk of dermatological products. This paper presents a PBPK workf... |
PMC11252255 | core_pubmed_pmc | L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice | L-carnitine co-administration prevents colistin-induced mitochondrial permeability transition and reduces the risk of acute kidney injury in mice Abstract Abstract Colistin is a polymyxin antibiotic currently experiencing renewed clinical interest due to its efficacy in the treatment of multidrug resistant (MDR) bacter... |
PMC3050839 | core_pubmed_pmc | The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery | The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery Abstract Abstract Background Surgical site infections are common, so effective antibiotic concentrations at the sites of infection are required. Surgery can lead to physiological changes influ... |
PMC10419486 | core_pubmed_pmc | Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms | Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms Abstract Abstract Potential medication errors and related adverse drug events (ADE) pose major challenges in clinical medicine. Clinical deci... |
PMC5834813 | core_pubmed_pmc | Nimotuzumab combined with concurrent chemoradiotherapy in Japanese patients with esophageal cancer: A phase I study | Nimotuzumab combined with concurrent chemoradiotherapy in Japanese patients with esophageal cancer: A phase I study Abstract Abstract Nimotuzumab is a humanized anti‐epidermal growth factor receptor IgG1 monoclonal antibody. This phase I study assessed the tolerability, safety, efficacy, and pharmacokinetics of nimotuz... |
PMC5836851 | core_pubmed_pmc | Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open‐Label, Randomized Study | Effect of Sorbitol on the Pharmacokinetic Profile of Lamivudine Oral Solution in Adults: An Open‐Label, Randomized Study Abstract In children aged ≤4 years, the relative bioavailability of lamivudine oral solution was 37% lower than that of a tablet formulation. An open‐label, four‐way crossover study was conducted in ... |
PMC12845406 | core_pubmed_pmc | Population Pharmacokinetics Model of Cyclosporin A in Children and Young Adult Renal Transplant Patients: Focus on Haemoglobin Contribution to Exposure Variability | Population Pharmacokinetics Model of Cyclosporin A in Children and Young Adult Renal Transplant Patients: Focus on Haemoglobin Contribution to Exposure Variability Abstract Abstract Background/Objectives : Cyclosporine A (CsA) is a key immunosuppressant in post-transplantation therapy protocol characterized by large in... |
PMC12890664 | core_pubmed_pmc | Long-acting growth hormone for pediatric GHD: insights into molecular modification and clinical application | Long-acting growth hormone for pediatric GHD: insights into molecular modification and clinical application Abstract Long-acting growth hormone (LAGH) therapies represent a paradigm shift in the management of growth hormone deficiency (GHD), alleviating the burden of daily injections. This review comprehensively evalua... |
PMC10009187 | core_pubmed_pmc | Improving the efficacy of plant-made anti-HIV monoclonal antibodies for clinical use | Improving the efficacy of plant-made anti-HIV monoclonal antibodies for clinical use Abstract Abstract Introduction Broadly neutralising antibodies are promising candidates for preventing and treating Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS), as an alternative to or in combination with... |
PMC12474378 | core_pubmed_pmc | Pharmacokinetics of Carprofen Administered Intravenously at Different Doses in Goats | Pharmacokinetics of Carprofen Administered Intravenously at Different Doses in Goats Abstract Simple Summary This study investigates the pharmacokinetics of carprofen, an anti-inflammatory drug, when administered intravenously to goats at different doses. Key findings indicate that carprofen had a prolonged effect in g... |
PMC7239339 | core_pubmed_pmc | Variability in the Log Domain and Limitations to Its Approximation by the Normal Distribution | Variability in the Log Domain and Limitations to Its Approximation by the Normal Distribution Abstract Pharmacometric models using lognormal distributions have become commonplace in pharmacokinetic–pharmacodynamic investigations. The extent to which it can be interpreted by traditional description of variability throug... |
PMC4773320 | core_pubmed_pmc | Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide | Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide Abstract Purpose Physiologically-based pharmacokinetic (PBPK) models provide a rational mechanistic approach for predicting the time course of macromolecules in plasma. Population PB... |
PMC5954844 | core_pubmed_pmc | Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite Allotransplantation: Optimizing Formulation and Preliminary Evaluation of Bioavailability and Pharmacokinetics | Mycophenolic Acid for Topical Immunosuppression in Vascularized Composite Allotransplantation: Optimizing Formulation and Preliminary Evaluation of Bioavailability and Pharmacokinetics Abstract Abstract Mycophenolic acid (MPA), is the active form of the ester prodrug mycophenolate mofetil (MMF). MMF is an FDA approved ... |
PMC9911982 | core_pubmed_pmc | An integrated in-silico Pharmaco-BioInformatics approaches to identify synergistic effects of COVID-19 to HIV patients | An integrated in-silico Pharmaco-BioInformatics approaches to identify synergistic effects of COVID-19 to HIV patients Abstract Background With high inflammatory states from both COVID-19 and HIV conditions further result in complications. The ongoing confrontation between these two viral infections can be avoided by a... |
PMC9123388 | core_pubmed_pmc | Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report | Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Ayahuasca Use in a Satanic Ritual: A Case Report Abstract Ayahuasca is a psychedelic blend originating from South America that has been used for hundreds of years by local tribes in ritualistic ceremonies. For the last few decades, its usage has expande... |
PMC4334652 | core_pubmed_pmc | Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load | Which Foods May Be Addictive? The Roles of Processing, Fat Content, and Glycemic Load Abstract Abstract Objectives We propose that highly processed foods share pharmacokinetic properties (e.g. concentrated dose, rapid rate of absorption) with drugs of abuse, due to the addition of fat and/or refined carbohydrates and t... |
PMC7351889 | core_pubmed_pmc | Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis | Water content of the endothelial glycocalyx layer estimated by volume kinetic analysis Abstract Background The water volume of the endothelial glycocalyx layer has been estimated at 0.7 to 1.7 L using tracer methods of unclear value. The present study attempts to measure this fluid volume by analyzing the kinetics of a... |
PMC10134572 | core_pubmed_pmc | Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract | Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract Abstract Inhalation is a portal-of-entry for aerosols via the respiratory tract where particulate burden accumulates depending on sites of particle deposition, normal clearance mechanisms, and particle s... |
PMC12807947 | core_pubmed_pmc | Spontaneous inferior epigastric artery hemorrhage in a COVID-19 patient with membranous nephropathy on anticoagulant therapy: a Case Report | Spontaneous inferior epigastric artery hemorrhage in a COVID-19 patient with membranous nephropathy on anticoagulant therapy: a Case Report Abstract Abstract Background The management of Coronavirus disease 2019 (COVID-19) is complicated by coagulopathies that increase both thrombotic and hemorrhagic risks, particularl... |
PMC9205818 | core_pubmed_pmc | Management of Pharmacologic Adverse Effects in Advanced Liver Disease | Management of Pharmacologic Adverse Effects in Advanced Liver Disease Abstract As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and ... |
PMC3362698 | core_pubmed_pmc | A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin | A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin Abstract Abstract Purpose This analysis determined the incidence of serious rhabdomyolysis events reported during trabectedin treatment since the first phase I clinical trial in April 1996 up to ... |
PMC9038101 | core_pubmed_pmc | Traditional uses, phytochemistry, pharmacology, and toxicology of Pterocephalus hookeri (C. B. Clarke) Höeck: a review | Traditional uses, phytochemistry, pharmacology, and toxicology of Pterocephalus hookeri (C. B. Clarke) Höeck: a review Abstract Pterocephalus hookeri (C. B. Clarke) Höeck is a member of the Dipsacaceae family and has been used in traditional Tibetan medicine for thousands of years. P. hookeri clears heat, detoxifies, s... |
PMC7996283 | core_pubmed_pmc | Population Pharmacokinetics of Palbociclib in a Real-World Situation | Population Pharmacokinetics of Palbociclib in a Real-World Situation Abstract Palbociclib is an oral cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer. Its metabolism profile is associated with an important inte... |
PMC7559355 | core_pubmed_pmc | Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin | Understanding the Half-Life Extension of Intravitreally Administered Antibodies Binding to Ocular Albumin Abstract Abstract The burden associated with frequent injections of current intravitreal (IVT) therapeutics may be reduced by long-acting delivery strategies. Binding to serum albumin has been shown to extend the o... |
PMC9593214 | core_pubmed_pmc | Ginkgo biloba leaf extract EGb 761 ® as a paragon of the product by process concept | Ginkgo biloba leaf extract EGb 761 ® as a paragon of the product by process concept Abstract It is an often-neglected fact that extracts derived from the very same plant can differ significantly in their phytochemical composition, and thus also in their pharmacokinetic and pharmacodynamic properties which are the basis... |
PMC12031897 | core_pubmed_pmc | Model-informed repurposing of eliglustat for treatment and prophylaxis of Shiga toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) in children | Model-informed repurposing of eliglustat for treatment and prophylaxis of Shiga toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) in children Abstract Background Shiga toxin-producing Escherichia coli hemolytic-uremic syndrome (STEC-HUS) is a severe illness predominantly affecting young children, wi... |
PMC8404630 | core_pubmed_pmc | Prevalence of CYP2C19 and ITGB3 polymorphisms among Bangladeshi patients who underwent percutaneous coronary intervention | Prevalence of CYP2C19 and ITGB3 polymorphisms among Bangladeshi patients who underwent percutaneous coronary intervention Abstract Abstract Introduction: Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, as... |
PMC12160805 | core_pubmed_pmc | A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction | A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction Abstract Abstract Aims Relaxin-2, a well-known human hormone primarily associated with pregnancy, has shown promising cardiovascular benefits in both pre-clinical models and clinical trials. Howeve... |
PMC3950497 | core_pubmed_pmc | Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma | Development of Mass Spectrometry Selected Reaction Monitoring Method for Quantitation and Pharmacokinetic Study of Stepharine in Rabbit Plasma Abstract Abstract Highly sensitive liquid chromatography mass spectrometry method on triple quadrupole (QQQ) mass spectrometer was successfully applied for pharmacokinetic study... |
PMC8261237 | core_pubmed_pmc | Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIRECT) | Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIRECT) Abstract Background Sepsis contributes significantly to morbidity and mortality globally. In Australia, 20,000 develop sepsis every year, resulting i... |
PMC7306621 | core_pubmed_pmc | Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling | Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling Abstract In quantitative systems pharmacology (QSP) and physiologically‐based pharmacokinetic (PBPK) modeling, data digitizing is a valuable tool to extract numerical informatio... |
PMC6554299 | core_pubmed_pmc | Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight | Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight Abstract Abstract As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to pr... |
PMC12056915 | core_pubmed_pmc | Safety and Efficacy of a Selective Inhibitor of Cyclin-dependent Kinase 9 (KB-0742) in Patients with Recurrent or Metastatic Adenoid Cystic Carcinoma | Safety and Efficacy of a Selective Inhibitor of Cyclin-dependent Kinase 9 (KB-0742) in Patients with Recurrent or Metastatic Adenoid Cystic Carcinoma Abstract Abstract Purpose: Adenoid cystic carcinoma (ACC) is a rare salivary gland malignancy of the head and neck. Recurrent or metastatic ACC has very limited therapeut... |
PMC6387601 | core_pubmed_pmc | Evaluation of pharmacokinetics and pharmacodynamics of sinomeninehyaluronic acid conjugate after intraarticular administration for osteoarthritis treatment | Evaluation of pharmacokinetics and pharmacodynamics of sinomeninehyaluronic acid conjugate after intraarticular administration for osteoarthritis treatment Abstract Objectives Intra-articular injection of sinomenine (SN) is an effective treatment method for knee osteoarthritis (OA), however, SN could be eliminated q... |
PMC9775864 | core_pubmed_pmc | Pharmacological Optimization of PSMA-Based Radioligand Therapy | Pharmacological Optimization of PSMA-Based Radioligand Therapy Abstract Abstract Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The standard treatment strategy for PCa ranges from active surveillance in low-grade, localized PCa to radical prostatectomy, external beam radiation thera... |
PMC6270200 | core_pubmed_pmc | Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats | Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats Abstract Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to tr... |
PMC5811050 | core_pubmed_pmc | Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence | Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence Abstract Background To make systemic anti-cancer therapy (SACT) preparation more practicable, dose-banding approaches are currently being introduced in many clinical centres. T... |
PMC10524044 | core_pubmed_pmc | Population modeling of bosutinib exposure‐response in patients with newly diagnosed chronic phase chronic myeloid leukemia | Population modeling of bosutinib exposure‐response in patients with newly diagnosed chronic phase chronic myeloid leukemia Abstract Abstract Background The BELA and BFORE trials compared bosutinib starting doses of 500 mg once daily (QD) and 400 mg QD, respectively, with imatinib in adults with newly diagnosed chronic ... |
PMC11310849 | core_pubmed_pmc | Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like receptor 7 agonist ruzotolimod | Using exploratory pharmacokinetic and pharmacodynamic analyses to predict the probability of flu‐like symptoms in healthy volunteers and patients with chronic hepatitis B treated with the toll‐like receptor 7 agonist ruzotolimod Abstract Abstract Ruzotolimod (Toll‐like receptor 7 (TLR7) agonist, RG7854) is an oral, sma... |
PMC6521569 | core_pubmed_pmc | A Validated HPLC-MS/MS Method for Simultaneous Determination of Militarine and Its Three Metabolites in Rat Plasma: Application to a Pharmacokinetic Study | A Validated HPLC-MS/MS Method for Simultaneous Determination of Militarine and Its Three Metabolites in Rat Plasma: Application to a Pharmacokinetic Study Abstract A rapid, reliable, and sensitive HPLC-electrospray ionization-tandem mass spectrometry (HPLC-MS/MS) method was established and validated for simultaneous de... |
PMC6027737 | core_pubmed_pmc | Systems Toxicology Approach to Identifying Paracetamol Overdose | Systems Toxicology Approach to Identifying Paracetamol Overdose Abstract Abstract Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury and even death. Promising APAP toxi... |
PMC6222669 | core_pubmed_pmc | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme | The Inhibitory Effect of Flavonoid Aglycones on the Metabolic Activity of CYP3A4 Enzyme Abstract Abstract Flavonoids are natural compounds that have been extensively studied due to their positive effects on human health. There are over 4000 flavonoids found in higher plants and their beneficial effects have been shown ... |
PMC3339728 | core_pubmed_pmc | A simple thermal pain model for the evaluation of analgesic activity in healthy subjects | A simple thermal pain model for the evaluation of analgesic activity in healthy subjects Abstract Abstract Objective: Assessment of the analgesic effect of an agent in an experimental pain model permits a level of control not possible in a clinical pain setting and is an ideal approach for evaluation of analgesic drugs... |
PMC4786061 | core_pubmed_pmc | Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics | Amsacrine analog-loaded solid lipid nanoparticle to resolve insolubility for injection delivery: characterization and pharmacokinetics Abstract Amsacrine analog is a novel chemotherapeutic agent that provides potentially broad antitumor activity when compared to traditional amsacrine. However, the major limitation of a... |
PMC9476740 | core_pubmed_pmc | Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics | Pharmacokinetic studies of multi-bioactive components in rat plasma after oral administration of Xintiantai Ⅰ extract and effects of guide drug borneol on pharmacokinetics Abstract Abstract Objective To investigate the in vivo pharmacokinetic characteristics of 17 bioactive components including ginsenoside Rg1, Rb1, Rd... |
PMC9427544 | core_pubmed_pmc | Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections | Efficacy, safety, tolerability and population pharmacokinetics of tedizolid, a novel antibiotic, in Latino patients with acute bacterial skin and skin structure infections Abstract Acute bacterial skin and skin structure infections are caused mainly by Gram-positive bacteria which are often treated with intravenous van... |
PMC9799288 | core_pubmed_pmc | Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis: Pharmacokinetic and toxicity assessment | Targeted delivery of ursolic acid and oleanolic acid to lungs in the form of an inhaler for the management of tuberculosis: Pharmacokinetic and toxicity assessment Abstract Abstract Introduction Ursolic acid (UA) and oleanolic acid (OA) are triterpenoids. They are used to treat numerous diseases, including tuberculosis... |
PMC3535355 | core_pubmed_pmc | Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors | Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors Abstract Purpose Omacetaxine mepesuccinate is a first-in-class cephalotaxine demonstrating clinical activity in chronic myeloid leukemia. A subcutaneous (SC) formulation demonstrated eff... |
PMC12655487 | core_pubmed_pmc | Camptothecin in Cancer Therapy: Current Challenges and Emerging Strategies with Nanoemulsions | Camptothecin in Cancer Therapy: Current Challenges and Emerging Strategies with Nanoemulsions Abstract Camptothecin (CPT) is a natural alkaloid with potent antiproliferative activity, mediated by the inhibition of Topoisomerase I (Topo I), an essential enzyme for deoxyribonucleic acid (DNA) replication. However, its cl... |
PMC6347715 | core_pubmed_pmc | AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis | AWZ1066S, a highly specific anti- Wolbachia drug candidate for a short-course treatment of filariasis Abstract Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current con... |
PMC10542348 | core_pubmed_pmc | Simultaneous LC–MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(−/ +) populations using dried blood spots | Simultaneous LC–MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(−/ +) populations using dried blood spots Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a global pandemic of coronavirus disease 2019 (COVID-19). Early in the pandemic, ... |
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