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PMC11358599 | core_pubmed_pmc | Willingness-to-use and preferences for model-informed antenatal doses: a cross-sectional study among European healthcare practitioners and pregnant women | Willingness-to-use and preferences for model-informed antenatal doses: a cross-sectional study among European healthcare practitioners and pregnant women Abstract Abstract Background: Physiological changes in pregnancy may affect drug safety and efficacy, sometimes requiring dose adjustments. Pregnancy-adjusted doses, ... |
PMC6161070 | core_pubmed_pmc | Oral Bioavailability and Lymphatic Transport of Pueraria Flavone-Loaded Self-Emulsifying Drug-Delivery Systems Containing Sodium Taurocholate in Rats | Oral Bioavailability and Lymphatic Transport of Pueraria Flavone-Loaded Self-Emulsifying Drug-Delivery Systems Containing Sodium Taurocholate in Rats Abstract We developed self-microemulsifying drug-delivery systems (SMEDDS), including bile salts, to improve the oral bioavailability of pueraria flavones (PFs). The phys... |
PMC9027396 | core_pubmed_pmc | Magnitude of Drug–Drug Interactions in Special Populations | Magnitude of Drug–Drug Interactions in Special Populations Abstract Abstract Drug–drug interactions (DDIs) are one of the most frequent causes of adverse drug reactions or loss of treatment efficacy. The risk of DDIs increases with polypharmacy and is therefore of particular concern in individuals likely to present com... |
PMC10221572 | core_pubmed_pmc | Comparative Susceptibility of Pathogenic Methicillin-Resistant and Methicillin-Susceptible Staphylococcus pseudintermedius to Empirical Cotrimazole for Canine Pyoderma | Comparative Susceptibility of Pathogenic Methicillin-Resistant and Methicillin-Susceptible Staphylococcus pseudintermedius to Empirical Cotrimazole for Canine Pyoderma Abstract The prevalence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) that causes pyoderma has been gradually shifting, according to m... |
PMC5529513 | core_pubmed_pmc | Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist | Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist Abstract Abstract Eph receptors have emerged as targets for therapy in both neoplastic and non-neoplastic disease, however, particularly in non-neoplastic diseases, redundancy of function limits the effec... |
PMC4937650 | core_pubmed_pmc | Bioequivalence study of two subcutaneous formulations of dalteparin: randomized, single-dose, two-sequence, two-period, cross-over study in healthy volunteers | Bioequivalence study of two subcutaneous formulations of dalteparin: randomized, single-dose, two-sequence, two-period, cross-over study in healthy volunteers Abstract Abstract Objective This study assessed relative bioavailability of a new subcutaneous formulation, test (T) (dalteparin sodium 95000 IU/3.8 mL) with the... |
PMC2991694 | core_pubmed_pmc | QTc interval prolongation by fexofenadine in healthy human volunteers and its correlation with plasma levels of fexofenadine: A demonstration of anticlockwise hysteresis | QTc interval prolongation by fexofenadine in healthy human volunteers and its correlation with plasma levels of fexofenadine: A demonstration of anticlockwise hysteresis Abstract Abstract Aim: The study was designed to establish relationship between the plasma concentration and QTc interval prolonging effect of fexofen... |
PMC9099557 | core_pubmed_pmc | Physiological Changes in Chicken Embryos Inoculated with Drugs and Viruses Highlight the Need for More Standardization of this Animal Model | Physiological Changes in Chicken Embryos Inoculated with Drugs and Viruses Highlight the Need for More Standardization of this Animal Model Abstract Abstract Simple Summary Over the years, the chicken embryo (CE) has been a widely used animal model, which is essential to decrease the number of born animals in experimen... |
PMC3080361 | core_pubmed_pmc | Chronic Delivery of Antibody Fragments Using Immunoisolated Cell Implants as a Passive Vaccination Tool | Chronic Delivery of Antibody Fragments Using Immunoisolated Cell Implants as a Passive Vaccination Tool Abstract Background Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinet... |
PMC10163090 | core_pubmed_pmc | Significant impact of time-of-day variation on metformin pharmacokinetics | Significant impact of time-of-day variation on metformin pharmacokinetics Abstract Aims/hypothesis The objective was to investigate if metformin pharmacokinetics is modulated by time-of-day in humans using empirical and mechanistic pharmacokinetic modelling techniques on a large clinical dataset. This study also aimed ... |
PMC8784973 | core_pubmed_pmc | Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives | Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives Abstract Abstract Sophoridine is a natural quinolizidine alkaloid and a bioactive ingredient that can be isolated and identified from certain herbs, including Sophora flavescens Alt, Sophora alopecur... |
PMC12878740 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Model of Magnesium Implant Absorption and Distribution in Tissue and Organs | Physiologically Based Pharmacokinetic Model of Magnesium Implant Absorption and Distribution in Tissue and Organs Abstract Abstract The long-term accumulation of magnesium (Mg(II)) ions in human patients resulting from the biodegradation of clinical Mg (alloy) implants is investigated using a physiologically based pha... |
PMC9982740 | core_pubmed_pmc | Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies | Monitoring of sirolimus in the whole blood samples from pediatric patients with lymphatic anomalies Abstract Abstract In recent years, off-label use of sirolimus (SIR) has been gaining attention in the clinical practice. However, since it is critical to achieve and maintain therapeutic blood levels of SIR during treatm... |
PMC7266109 | core_pubmed_pmc | An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study | An LC-MS/MS Bioanalytical Assay for the Determination of Gilteritinib in Rat Plasma and Application to a Drug–Drug Interaction Study Abstract Abstract Background Gilteritinib, a novel, potent FLT3/AXL inhibitor, was recently approved in Japan and USA for the treatment of adult patients who have relapsed or refractory a... |
PMC8752111 | core_pubmed_pmc | Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers | Population pharmacokinetic–pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers Abstract Abstract PB2452, a neutralizing monoclonal antibody fragment that binds the antiplatelet drug ticagrelor with high affinity, is being developed as ... |
PMC9297986 | core_pubmed_pmc | Clinical application of vancomycin population pharmacokinetics model in patients with hematological diseases and neutropenia | Clinical application of vancomycin population pharmacokinetics model in patients with hematological diseases and neutropenia Abstract Abstract To explore the clinical application of a population pharmacokinetics (PPK) model of vancomycin in patients with hematological diseases and neutropenia. Patients with hematologic... |
PMC5796250 | core_pubmed_pmc | Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide | Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide Abstract Tripterygium wilfordii (TW) and the representative active component triptolide show positive therapeutic effect on the autoim... |
PMC11727039 | core_pubmed_pmc | Advances in Natural-Product-Based Fluorescent Agents and Synthetic Analogues for Analytical and Biomedical Applications | Advances in Natural-Product-Based Fluorescent Agents and Synthetic Analogues for Analytical and Biomedical Applications Abstract Abstract Fluorescence is a remarkable property exhibited by many chemical compounds and biomolecules. Fluorescence has revolutionized analytical and biomedical sciences due to its wide-rangin... |
PMC11646930 | core_pubmed_pmc | Population pharmacokinetic analysis of zastaprazan (JP‐1366), a novel potassium‐competitive acid blocker, in patients and healthy volunteers | Population pharmacokinetic analysis of zastaprazan (JP‐1366), a novel potassium‐competitive acid blocker, in patients and healthy volunteers Abstract Abstract Zastaprazan (JP‐1366) is a novel potassium‐competitive acid blocker for the treatment of acid‐related disorders. We aimed to establish a population pharmacokinet... |
PMC12806652 | core_pubmed_pmc | Sex differences in efficacy/safety of anti-amyloid-beta monoclonal antibodies for the treatment of Alzheimer’s disease | Sex differences in efficacy/safety of anti-amyloid-beta monoclonal antibodies for the treatment of Alzheimer’s disease Abstract Alzheimer’s disease (AD) is the most common cause of dementia. AD exhibits notable sex-related disparities in prevalence, progression, and treatment response. With the recent approval of anti–... |
PMC4452933 | core_pubmed_pmc | A Joint Model for the Kinetics of CTC Count and PSA Concentration During Treatment in Metastatic Castration-Resistant Prostate Cancer * | A Joint Model for the Kinetics of CTC Count and PSA Concentration During Treatment in Metastatic Castration-Resistant Prostate Cancer * Abstract Assessment of treatment efficacy in metastatic castration-resistant prostate cancer (mCRPC) is limited by frequent nonmeasurable bone metastases. The count of circulating tumo... |
PMC11053970 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of a Nanostructured Lipid Carrier Co-Encapsulating Artemether and miRNA for Mitigating Cerebral Malaria | Pharmacokinetics and Pharmacodynamics of a Nanostructured Lipid Carrier Co-Encapsulating Artemether and miRNA for Mitigating Cerebral Malaria Abstract Cerebral malaria (CM), a severe neurological pathology caused by Plasmodium falciparum infection, poses a significant global health threat and has a high mortality rate.... |
PMC12574104 | core_pubmed_pmc | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation | Pharmacokinetic Interaction Between Tacrolimus and Fentanyl in Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation Abstract Abstract Background Tacrolimus and fentanyl are well-known cytochrome P450 (CYP) 3A4 substrates with a narrow therapeutic range. However, the pharmacokinetic interaction between ... |
PMC9585574 | core_pubmed_pmc | A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs | A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs Abstract Abstract Chemotherapy is almost exclusively administered via the intravenous (IV) route, which has serious limitations (e.g., patient discomfort, long hospital stays, need for trained staff, high co... |
PMC9010257 | core_pubmed_pmc | Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor | Phase I studies of the safety, tolerability, pharmacokinetics, and pharmacodynamics of DS‐1211, a tissue‐nonspecific alkaline phosphatase inhibitor Abstract Abstract Tissue‐nonspecific alkaline phosphatase (TNAP) hydrolyzes and inactivates inorganic pyrophosphate (PPi), a potent inhibitor of calcification; therefore, T... |
PMC9890192 | core_pubmed_pmc | Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate | Associations between CES1 variants and dosing and adverse effects in children taking methylphenidate Abstract Background Methylphenidate is the most prescribed stimulant to treat attention deficit-hyperactivity disorder (ADHD). Despite its widespread usage, a fair proportion of children are classified as non-responders... |
PMC6170670 | core_pubmed_pmc | Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects | Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects Abstract Abstract Background In type 2 diabetes mellitus therapy, fixed-dose combination (FDC) can offer n... |
PMC7716902 | core_pubmed_pmc | Pharmacokinetics and Glucodynamics of Ultra Rapid Lispro (URLi) versus Humalog ® (Lispro) in Patients with Type 2 Diabetes Mellitus: A Phase I Randomised, Crossover Study | Pharmacokinetics and Glucodynamics of Ultra Rapid Lispro (URLi) versus Humalog ® (Lispro) in Patients with Type 2 Diabetes Mellitus: A Phase I Randomised, Crossover Study Abstract Abstract Background and objective Ultra rapid lispro (URLi) is a novel insulin lispro formulation developed to more closely match physiologi... |
PMC7841331 | core_pubmed_pmc | Control Theory and Cancer Chemotherapy: How They Interact | Control Theory and Cancer Chemotherapy: How They Interact Abstract Abstract Control theory arises in most modern real-life applications, not least in biological and medical applications. In particular, in biological and medical contexts, the role of control theory began to take shape in the early 1980s when the first w... |
PMC8789534 | core_pubmed_pmc | In silico to In vivo development of a polyherbal against Haemonchus contortus | In silico to In vivo development of a polyherbal against Haemonchus contortus Abstract Abstract Haemonchus contortus is a major constraint in the development of small ruminant subsector due to significant production losses incurred by it. The present study explores the antiparasitic potential of three anthelmintic plan... |
PMC11988800 | core_pubmed_pmc | A Comprehensive In Vitro and In Silico Approach for Targeting 4-Hydroxyphenyl Pyruvate Dioxygenase: Towards New Therapeutics for Alkaptonuria | A Comprehensive In Vitro and In Silico Approach for Targeting 4-Hydroxyphenyl Pyruvate Dioxygenase: Towards New Therapeutics for Alkaptonuria Abstract Abstract Alkaptonuria (AKU) is an ultra-rare genetic disorder caused by mutations in the homogentisate 1,2-dioxygenase ( HGD ) gene, leading to the accumulation of homog... |
PMC11031431 | core_pubmed_pmc | A Dutch Survey on Medication Adjustments after Metabolic and Bariatric Surgery: Experiences of Bariatric Surgeons, Internists, Pharmacists, and General Practitioners | A Dutch Survey on Medication Adjustments after Metabolic and Bariatric Surgery: Experiences of Bariatric Surgeons, Internists, Pharmacists, and General Practitioners Abstract Abstract Background As metabolic and bariatric surgery (MBS) can alter the pharmacokinetics of drugs, post-bariatric surgery patients may require... |
PMC12692739 | core_pubmed_pmc | Docosahexaenoic Acid-Driven Metabolic Reprogramming as an Attractive Anti-Infection Strategy to Potentiate β-Lactam Antibiotic Efficacy | Docosahexaenoic Acid-Driven Metabolic Reprogramming as an Attractive Anti-Infection Strategy to Potentiate β-Lactam Antibiotic Efficacy Abstract Abstract The emergence and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) severely compromises conventional β-lactam antibiotics efficacy and poses an extens... |
PMC12917324 | core_pubmed_pmc | Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols | Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols Abstract ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to ... |
PMC5516778 | core_pubmed_pmc | Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles | Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles Abstract Abstract Arenobufagin (ABG) is a major active component of toad venom, a traditional Chinese medicine used for cancer therapy. However, poor aqueous solubility limits its pharmacological studies in vivo due to administration di... |
PMC12159046 | core_pubmed_pmc | Multi-physiology modeling of the immune system in the era of precision immunotherapy | Multi-physiology modeling of the immune system in the era of precision immunotherapy Abstract Abstract Immunotherapies using new modalities, including antibody-based drugs, nanoparticle-delivered drugs, and adoptive cell therapy, have become major treatment options for immune-related diseases such as cancer, autoimmune... |
PMC3933580 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Models in the Prediction of Oral Drug Exposure Over the Entire Pediatric Age Range—Sotalol as a Model Drug | Physiologically Based Pharmacokinetic Models in the Prediction of Oral Drug Exposure Over the Entire Pediatric Age Range—Sotalol as a Model Drug Abstract Abstract In recent years, the increased interest in pediatric research has enforced the role of physiologically based pharmacokinetic (PBPK) models in pediatric drug ... |
PMC11810598 | core_pubmed_pmc | GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules | GutBugDB: a web resource to predict the human gut microbiome-mediated biotransformation of biotic and xenobiotic molecules Abstract Abstract There has been a growing recognition of the significant role played by the human gut microbiota in altering the bioavailability as well as the pharmacokinetic and pharmacodynamic ... |
PMC8608910 | core_pubmed_pmc | Advancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function | Advancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function Abstract Plasma clearance of iohexol is a pivotal metric to quantify glomerular filtration rate (GFR), but the optimal timing and frequency of plasma sampling remain to be assessed. In this study, we evalua... |
PMC4302229 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of nab -paclitaxel in patients with solid tumors: Disposition kinetics and pharmacology distinct from solvent-based paclitaxel | Pharmacokinetics and pharmacodynamics of nab -paclitaxel in patients with solid tumors: Disposition kinetics and pharmacology distinct from solvent-based paclitaxel Abstract The aim of this study was to characterize population pharmacokinetics and the exposure–neutropenia relationship with nanoparticle albumin-bound ( ... |
PMC9784843 | core_pubmed_pmc | Torsemide Pharmacometrics in Healthy Adult Populations Including CYP2C9 Genetic Polymorphisms and Various Patient Groups through Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling | Torsemide Pharmacometrics in Healthy Adult Populations Including CYP2C9 Genetic Polymorphisms and Various Patient Groups through Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling Abstract Abstract Torsemide is a widely used diuretic in clinical practice. In this study, pharmacokinetic (PK) and pharmacodyna... |
PMC11904693 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Model of Plasma and Intracranial Pharmacokinetics and CDK4/6 Occupancy of Abemaciclib to Optimizing Dosing Regimen for Brain Metastatic Patients | Physiologically Based Pharmacokinetic Model of Plasma and Intracranial Pharmacokinetics and CDK4/6 Occupancy of Abemaciclib to Optimizing Dosing Regimen for Brain Metastatic Patients Abstract Objective : The study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict steady state trough conce... |
PMC5613186 | core_pubmed_pmc | Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib‐Treated Cancer | Population Modeling Integrating Pharmacokinetics, Pharmacodynamics, Pharmacogenetics, and Clinical Outcome in Patients With Sunitinib‐Treated Cancer Abstract Abstract The tyrosine kinase inhibitor sunitinib is used as first‐line therapy in patients with metastasized renal cell carcinoma (mRCC), given in fixed‐dose regi... |
PMC8316415 | core_pubmed_pmc | Biodistribution and internal radiation dosimetry of a companion diagnostic radiopharmaceutical, [ 68 Ga]PSMA-11, in subcutaneous prostate cancer xenograft model mice | Biodistribution and internal radiation dosimetry of a companion diagnostic radiopharmaceutical, [ 68 Ga]PSMA-11, in subcutaneous prostate cancer xenograft model mice Abstract Abstract [ 68 Ga]PSMA-11 is a prostate-specific membrane antigen (PSMA)-targeting radiopharmaceutical for diagnostic PET imaging. Its application... |
PMC9243782 | core_pubmed_pmc | Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM ) | Safety and pharmacokinetics of a highly bioavailable resveratrol preparation (JOTROL TM ) Abstract Resveratrol exhibits a wide range of biological properties, including anti-glycation, antioxidant, anti-inflammation, neuroprotective (including against advanced dementia and Alzheimer’s disease), anti-cancer, and anti-ag... |
PMC3137052 | core_pubmed_pmc | Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes * | Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes * Abstract CS-0777 is a selective sphingosine 1-phosphate (S1P) receptor 1 modulator with potential benefits in the treatment of autoimmune diseases, including multiple sclerosis. ... |
PMC9962663 | core_pubmed_pmc | Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen | Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen Abstract Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective cova... |
PMC12685749 | core_pubmed_pmc | Effects of Esketamine-Dexmedetomidine Combination on Immediate Postprocedural Oxygenation Index in Severe Pneumonia Patients Undergoing Bedside Fiberoptic Bronchoscopic Sputum Aspiration: A Prospective Randomised Controlled Trial | Effects of Esketamine-Dexmedetomidine Combination on Immediate Postprocedural Oxygenation Index in Severe Pneumonia Patients Undergoing Bedside Fiberoptic Bronchoscopic Sputum Aspiration: A Prospective Randomised Controlled Trial Abstract Abstract Purpose The aim was to investigate the effect of esketamine-dexmedetomid... |
PMC10658493 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl | Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl Abstract Abstract Background Working dogs exposed to narcotics might require reversal in the field. Objective To explore the pharmacokinetic and pharmacodynamic effects of naloxone admi... |
PMC3525601 | core_pubmed_pmc | IDO inhibits a tryptophan sufficiency signal that stimulates mTOR | IDO inhibits a tryptophan sufficiency signal that stimulates mTOR Abstract Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) alters inflammation and favors T-cell tolerance in cancer, but the underlying molecular mechanisms remain poorly understood. The integrated stress response kinase GCN2, a sensor of uncha... |
PMC4868321 | core_pubmed_pmc | Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study | Rethinking Dosing Regimen Selection of Piperaquine for Malaria Chemoprevention: A Simulation Study Abstract Abstract Background The combination of short-acting dihydroartemisinin and long-acting piperaquine (DP) is among the first-line therapies for the treatment of uncomplicated Plasmodium falciparum malaria . Populat... |
PMC3606941 | core_pubmed_pmc | A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction | A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction Abstract Abstract Besides logistical and ethical concerns, evaluation of safety and efficacy of medications in pregnant women is complicated by marked changes in pharmacokinetics (PK... |
PMC9286641 | core_pubmed_pmc | Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials | Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials Abstract Abstract Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including subjective drug effects and behavioural effects, and cannabinoid pharmacokinetics. This i... |
PMC7746418 | core_pubmed_pmc | H 2 S in acute lung injury: a therapeutic dead end(?) | H 2 S in acute lung injury: a therapeutic dead end(?) Abstract This review addresses the plausibility of hydrogen sulfide (H 2 S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The review discusses how the narrow therapeutic w... |
PMC7979853 | core_pubmed_pmc | An international survey on aminoglycoside practices in critically ill patients: the AMINO III study | An international survey on aminoglycoside practices in critically ill patients: the AMINO III study Abstract Background While aminoglycosides (AG) have been used for decades, debate remains on their optimal dosing strategy. We investigated the international practices of AG usage specifically regarding dosing and therap... |
PMC12209684 | core_pubmed_pmc | Pharmacokinetics of Two Formulations of Altrenogest Administered to Mares | Pharmacokinetics of Two Formulations of Altrenogest Administered to Mares Abstract ABSTRACT Altrenogest is a synthetic progestin that suppresses reproductive behaviours and assists pregnancy maintenance in female horses. Two formulations are available, a 'weekly' intramuscular injection and a daily oral formulation. Al... |
PMC10775801 | core_pubmed_pmc | Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS | Pharmacokinetics, Bioavailability, and Tissue Distribution of the Kirsten Rat Sarcoma Inhibitor Adagrasib in Rats Using UPLC-MS/MS Abstract Purpose Adagrasib is a selective and reversible inhibitor of KRAS G12C, which significantly delays the progression of solid tumors. However, the absorption, distribution, metabolis... |
PMC5953982 | core_pubmed_pmc | Leveraging model-informed approaches for drug discovery and development in the cardiovascular space | Leveraging model-informed approaches for drug discovery and development in the cardiovascular space Abstract Abstract Cardiovascular disease remains a significant global health burden, and development of cardiovascular drugs in the current regulatory environment often demands large and expensive cardiovascular outcome ... |
PMC6258404 | core_pubmed_pmc | Pazopanib: Evidence review and clinical practice in the management of advanced renal cell carcinoma | Pazopanib: Evidence review and clinical practice in the management of advanced renal cell carcinoma Abstract Background Pazopanib is indicated in the first-line treatment of metastatic renal cell cancer (mRCC). The aim of this study was to review the efficacy, safety, and pharmacokinetics of pazopanib and see how these... |
PMC7919699 | core_pubmed_pmc | Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Lisdexamfetamine in Healthy Adults | Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Lisdexamfetamine in Healthy Adults Abstract Supplemental digital content is available in the text. Key Words: viloxazine, SPN-812, attention-deficit/hyperactivity disorder, lisdexamfetamine, pharmacokinetics Abstract Background Viloxazine exte... |
PMC5702905 | core_pubmed_pmc | Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models | Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models Abstract Abstract The aim of this study was to investigate pharmacodynamic (PD) interactions in mice infected with Mycobacterium tuberculosis using population pharmacokinetics (... |
PMC8252065 | core_pubmed_pmc | Long‐Term Safety and Efficacy of Anifrolumab in Adults With Systemic Lupus Erythematosus: Results of a Phase II Open‐Label Extension Study | Long‐Term Safety and Efficacy of Anifrolumab in Adults With Systemic Lupus Erythematosus: Results of a Phase II Open‐Label Extension Study Abstract Objective To investigate long‐term safety and tolerability of anifrolumab, a human monoclonal antibody to the type I interferon (IFN) receptor subunit 1, in patients with m... |
PMC9787748 | core_pubmed_pmc | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis | Dose assessment of melatonin in sepsis (DAMSEL2) study: Pharmacokinetics of two doses of oral melatonin in patients with sepsis Abstract Abstract Sepsis is defined as a dysregulated host response to infection, and high‐dose melatonin has been proposed as a treatment due to its antioxidant and anti‐inflammatory properti... |
PMC10423819 | core_pubmed_pmc | The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19 | The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19 Abstract To effectively respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an increasing number of researchers are focusing on t... |
PMC12589998 | core_pubmed_pmc | Development and validation of a UHPLC-QqQ-MS/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study | Development and validation of a UHPLC-QqQ-MS/MS method for simultaneous determination of fifteen major components from Oroxyli seed extract in rat plasma and its application in the pharmacokinetic study Abstract For this investigation, a UHPLC-QqQ-MS/MS method was developed for the simultaneous determination of 15 comp... |
PMC11674801 | core_pubmed_pmc | Rare ginsenosides: A unique perspective of ginseng research | Rare ginsenosides: A unique perspective of ginseng research Abstract Highlights • Rare ginsenosides (RGs), as the shining components, possessed great potential in drugs and nutraceuticals. • A total of 144 rare ginsenosides with diverse skeletons and bioactivities were isolated from Panax species. • RGs showed superior... |
PMC8602582 | core_pubmed_pmc | Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection | Clinical and Preclinical Single-Dose Pharmacokinetics of VIR-2218, an RNAi Therapeutic Targeting HBV Infection Abstract Abstract Background and Objective VIR-2218 is an investigational N -acetylgalactosamine–conjugated RNA interference therapeutic in development for chronic hepatitis B virus (HBV) infection. VIR-2218 w... |
PMC6853148 | core_pubmed_pmc | Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis | Model‐Informed Dosing of Venetoclax in Healthy Subjects: An Exposure−Response Analysis Abstract Venetoclax is an approved drug for the treatment of some hematological malignancies. Venetoclax can cause reduction in B‐lymphocyte counts as an on‐target effect. The purpose of this analysis is to quantify the relationship ... |
PMC11859130 | core_pubmed_pmc | Synergistic Interaction Between Justicia spicigera Extract and Analgesics on the Formalin Test in Rats | Synergistic Interaction Between Justicia spicigera Extract and Analgesics on the Formalin Test in Rats Abstract Abstract Background: Combining antinociceptive drugs with different mechanisms of action can reduce the doses and the adverse effects, with a possible increase in the antinociceptive effect. This work evaluat... |
PMC12368482 | core_pubmed_pmc | Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives | Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives Abstract To further extend the structure‐activity relationships of previously reported antimalarial anilino‐pyrazoles VI , trisubstituted pyrazoles 13–15, and pyrimidines 16 and 17 are designed and synthesized. The novel derivatives are pr... |
PMC7170868 | core_pubmed_pmc | Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals | Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals Abstract Abstract Time courses of compound concentrations in plasma are used in chemical safety analysis to evaluate the relationship between external administered doses and internal tissue exposures. This type of experimental d... |
PMC8431452 | core_pubmed_pmc | Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients | Pharmacokinetic Drug–Drug Interactions among Antiepileptic Drugs, Including CBD, Drugs Used to Treat COVID-19 and Nutrients Abstract Abstract Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol... |
PMC4332724 | core_pubmed_pmc | Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib | Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib Abstract Background Regorafenib, a multi-kinase inhibitor, is used in the treatment of patients with metastatic colorectal cancer refractory to standard therapy. However, this benefit was limi... |
PMC9377451 | core_pubmed_pmc | Case Report: Functional and Symptomatic Improvement With Cariprazine in Various Psychiatric Patients: A Case Series | Case Report: Functional and Symptomatic Improvement With Cariprazine in Various Psychiatric Patients: A Case Series Abstract Cariprazine is a third-generation antipsychotic medication approved for the treatment of schizophrenia and bipolar disorder, with unique pharmacodynamic and pharmacokinetic properties. In this ca... |
PMC12030534 | core_pubmed_pmc | Population Pharmacokinetic Modeling of Total and Unbound Pamiparib in Glioblastoma Patients: Insights into Drug Disposition and Dosing Optimization | Population Pharmacokinetic Modeling of Total and Unbound Pamiparib in Glioblastoma Patients: Insights into Drug Disposition and Dosing Optimization Abstract Abstract Background: This study aimed to develop a population pharmacokinetic (PK) model that characterized the plasma concentration–time profiles of the total and... |
PMC6471481 | core_pubmed_pmc | Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time | Mathematical Modelling of Intravenous Thrombolysis in Acute Ischaemic stroke: Effects of Dose Regimens on Levels of Fibrinolytic Proteins and Clot Lysis Time Abstract Abstract Thrombolytic therapy is one of the medical procedures in the treatment of acute ischaemic stroke (AIS), whereby the tissue plasminogen activator... |
PMC7970465 | core_pubmed_pmc | In Silico Prediction of Fraction Unbound in Human Plasma from Chemical Fingerprint Using Automated Machine Learning | In Silico Prediction of Fraction Unbound in Human Plasma from Chemical Fingerprint Using Automated Machine Learning Abstract Abstract Predicting the fraction unbound of a drug in plasma plays a significant role in understanding its pharmacokinetic properties during in vitro studies of drug design and discovery. Owing t... |
PMC8302243 | core_pubmed_pmc | Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment | Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment Abstract Abstract Physiologically based pharmacokinetic (PBPK) models have been proposed as a tool for more accurate individual pharmacokinetic (PK) predictions and model‐informed precision dosing, but the... |
PMC8912008 | core_pubmed_pmc | Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) | Pharmacokinetic Study of Withanosides and Withanolides from Withania somnifera Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-MS/MS) Abstract Abstract Withania somnifera is a traditional Indian herb described under the ‘Rasayana’ class in Ayurveda, which gained immense popularity as ... |
PMC12472979 | core_pubmed_pmc | Dietary Modulation of CYP3A4 and Its Impact on Statins and Antidiabetic Drugs: A Narrative Review | Dietary Modulation of CYP3A4 and Its Impact on Statins and Antidiabetic Drugs: A Narrative Review Abstract Abstract Cytochrome P450 3A4 (CYP3A4) is a key enzyme involved in the metabolism of nearly half of all clinically used drugs, including widely prescribed statins and antidiabetic agents. Dietary constituents can m... |
PMC11599873 | core_pubmed_pmc | Assessment of pharmacokinetics and tolerability following single‐dose administration of molnupiravir in participants with hepatic or renal impairment | Assessment of pharmacokinetics and tolerability following single‐dose administration of molnupiravir in participants with hepatic or renal impairment Abstract Abstract Individuals with chronic liver or kidney disease are at increased risk of severe COVID‐19. Molnupiravir is an orally administered antiviral authorized f... |
PMC9585468 | core_pubmed_pmc | Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors | Potential interactions between uraemic toxins and drugs: an application in kidney transplant recipients treated with calcineurin inhibitors Abstract Abstract Background The uraemic toxins that accumulate as renal function deteriorates can potentially affect drug pharmacokinetics. This study’s objective was to determine... |
PMC12354953 | core_pubmed_pmc | Pushing the boundaries of few-shot learning for low-data drug discovery with a Bayesian meta-learning hypernetwork framework | Pushing the boundaries of few-shot learning for low-data drug discovery with a Bayesian meta-learning hypernetwork framework Abstract Abstract Hunting for candidate compounds with favorable pharmacological, toxicological, and pharmacokinetic properties in drug discovery is essentially a low-data problem, as data acquis... |
PMC3293077 | core_pubmed_pmc | Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects | Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects Abstract Abstract Background High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 ... |
PMC12163068 | core_pubmed_pmc | Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer | Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer Abstract Cervical cancer, primarily caused by persistent infection with high-risk human papillomavirus strains, leads to abnormal cell growth in the cervix. Globally, it accounts for over 600,000 new cases and 340,... |
PMC12218957 | core_pubmed_pmc | Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects | Exploring Pharmacokinetic interactions between SHR8554, a µ-opioid receptor biased agonist, and Itraconazole in healthy Chinese subjects Abstract SHR8554 is a biased agonist for µ-opioid receptors, which was under investigation as an alternative therapy for clinical pain. This open, fixed-sequence study evaluated its p... |
PMC12512093 | core_pubmed_pmc | Assessment of peripheral blood DNA methylation signatures as pharmacodynamic and predictive biomarkers during azacitidine therapy in juvenile myelomonocytic leukaemia: Results of the EWOG ‐ MESRAT study | Assessment of peripheral blood DNA methylation signatures as pharmacodynamic and predictive biomarkers during azacitidine therapy in juvenile myelomonocytic leukaemia: Results of the EWOG ‐ MESRAT study Abstract Summary EWOG‐MESRAT (European Working Group— Me thylation S ignatures and R esponse to A zacitidine T herapy... |
PMC10745846 | core_pubmed_pmc | Pharmacokinetics and Safety of Group A and B Anti-Tuberculosis Drugs Used in Treatment of Rifampicin-Resistant Tuberculosis during Pregnancy and Post-Partum: A Narrative Review | Pharmacokinetics and Safety of Group A and B Anti-Tuberculosis Drugs Used in Treatment of Rifampicin-Resistant Tuberculosis during Pregnancy and Post-Partum: A Narrative Review Abstract Recommendations for treatment of rifampicin-resistant tuberculosis (RR-TB) during pregnancy and post-partum now include Group A and B ... |
PMC10272298 | core_pubmed_pmc | Population pharmacokinetics and exposure‐response analysis of a single dose of sotrovimab in the early treatment of patients with mild to moderate COVID‐19 | Population pharmacokinetics and exposure‐response analysis of a single dose of sotrovimab in the early treatment of patients with mild to moderate COVID‐19 Abstract Abstract Sotrovimab is a recombinant human monoclonal antibody that has been shown to prevent progression to hospitalization or death in non‐hospitalized h... |
PMC9686642 | core_pubmed_pmc | Evaluation of Fosfomycin-Sulbactam Combination Therapy against Carbapenem-Resistant Acinetobacter baumannii Isolates in a Hollow-Fibre Infection Model | Evaluation of Fosfomycin-Sulbactam Combination Therapy against Carbapenem-Resistant Acinetobacter baumannii Isolates in a Hollow-Fibre Infection Model Abstract Static concentration in vitro studies have demonstrated that fosfomycin- or sulbactam-based combinations may be efficacious against carbapenem-resistant Acineto... |
PMC11700424 | core_pubmed_pmc | Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies | Sex-related differences in heart failure patients: physiological mechanisms of cardiovascular ageing and evidence-based sex-specific medical therapies Abstract This review aims to describe the sex differences in heart failure (HF) patients, with a particular emphasis on the effect of cardiovascular ageing. Additionally... |
PMC10003146 | core_pubmed_pmc | Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques | Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques Abstract Abstract Pharmaceutical application of therapeutic proteins has been continuously expanded for the treatment of various diseases. Efficient and reliable bioanalytical methods are essential to expedit... |
PMC5742761 | core_pubmed_pmc | Binge Alcohol Exposure Transiently Changes the Endocannabinoid System: A Potential Target to Prevent Alcohol-Induced Neurodegeneration | Binge Alcohol Exposure Transiently Changes the Endocannabinoid System: A Potential Target to Prevent Alcohol-Induced Neurodegeneration Abstract Abstract Excessive alcohol consumption leads to neurodegeneration, which contributes to cognitive decline that is associated with alcohol use disorders (AUDs). The endocannabin... |
PMC5857000 | core_pubmed_pmc | Potential Drug-Drug Interactions among Patients prescriptions collected from Medicine Out-patient Setting | Potential Drug-Drug Interactions among Patients prescriptions collected from Medicine Out-patient Setting Abstract Objective: To identify and evaluate the frequency, severity, mechanism and common pairs of drug-drug interactions (DDIs) in prescriptions by consultants in medicine outpatient department. Methods: This cro... |
PMC10777824 | core_pubmed_pmc | Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis | Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis Abstract ABSTRACT Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in children. There is only limited safety and... |
PMC8183774 | core_pubmed_pmc | Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia | Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia Abstract Abstract Pathophysiological changes are important risk factors for critically ill patients with pneumonia manifesting sub-therapeutic antibiotic exposures during empirical treatment. The effect of coronavirus diseas... |
PMC12908980 | core_pubmed_pmc | Pharmacokinetic-guided magnesium prophylaxis in cardiac surgery: A randomized trial demonstrating guideline-level reductions in atrial fibrillation, accelerated recovery, and systemic cost savings | Pharmacokinetic-guided magnesium prophylaxis in cardiac surgery: A randomized trial demonstrating guideline-level reductions in atrial fibrillation, accelerated recovery, and systemic cost savings Abstract Abstract Objective To evaluate the efficacy, safety, and cost-effectiveness of a perioperative magnesium (Mg) sulf... |
PMC10507719 | core_pubmed_pmc | The influence of methotrexate-related transporter and metabolizing enzyme gene polymorphisms on peri-engraftment syndrome and graft-versus-host disease after haplo-hematopoietic stem cell transplantation in pediatric patients with malignant hematological diseases | The influence of methotrexate-related transporter and metabolizing enzyme gene polymorphisms on peri-engraftment syndrome and graft-versus-host disease after haplo-hematopoietic stem cell transplantation in pediatric patients with malignant hematological diseases Abstract Abstract Background Methotrexate (MTX), utilize... |
PMC4433273 | core_pubmed_pmc | Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial | Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled Trial Abstract The aim of this study was to evaluate the safety, tolerability and pharmacokinetics of single dose of Melissa officinalis extract which contained rosmar... |
PMC9602269 | core_pubmed_pmc | The Selection of Antibiotic- and Bacteriophage-Resistant Pseudomonas aeruginosa Is Prevented by Their Combination | The Selection of Antibiotic- and Bacteriophage-Resistant Pseudomonas aeruginosa Is Prevented by Their Combination Abstract ABSTRACT Bacteria developing resistance compromise the efficacy of antibiotics or bacteriophages (phages). We tested the association of these two antibacterials to circumvent resistance. With the H... |
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