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PMC7930822 | core_pubmed_pmc | Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors | Phase I Trial to Evaluate the Tolerance, Pharmacokinetics and Efficacy of the Broad-Spectrum ErbB Family Inhibitor Larotinib Mesylate in Patients With Advanced Solid Tumors Abstract Background: The presented phase I, first-in-human study evaluated the tolerance, pharmacokinetics, and preliminary efficacy of larotinib m... |
PMC12474700 | core_pubmed_pmc | Superior Bioavailability of a Novel 1.5% Ashwagandha Formulation (Zenroot™): A Randomized, Double-Blind, Single-Dose, Comparative, Oral Bioavailability Study in Healthy Adults | Superior Bioavailability of a Novel 1.5% Ashwagandha Formulation (Zenroot™): A Randomized, Double-Blind, Single-Dose, Comparative, Oral Bioavailability Study in Healthy Adults Abstract Abstract Introduction Ashwagandha has multiple medicinal properties and is widely used as a supplement to address various health condit... |
PMC10561288 | core_pubmed_pmc | Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review | Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review Abstract Introduction Long used in traditional medicine, Nigella sativa (NS; Ranunculaceae) has shown significant efficacy as an adjuvant therapy for diabetes mellitus (DM) management by improving glucose tolerance, decreasing hepatic glu... |
PMC7151681 | core_pubmed_pmc | Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population | Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population Abstract Abstract A number of barriers and challenges must be overcome in order to conduct the pharmacokinetic studies that are urgently needed to inform the selection and dosing of medication in neonates. However,... |
PMC4185191 | core_pubmed_pmc | Pharmacokinetics and safety issues of an accidental overdose of 2,000,000 IU of vitamin D 3 in two nursing home patients: a case report | Pharmacokinetics and safety issues of an accidental overdose of 2,000,000 IU of vitamin D 3 in two nursing home patients: a case report Abstract Background Administration of intermittent high doses of vitamin D 3 is increasingly used as a strategy for rapid normalization of low 25-hydroxyvitamin D (25(OH)D) blood conce... |
PMC10092235 | core_pubmed_pmc | Safety, Pharmacokinetics, and Pharmacodynamics of CC‐90001 (BMS‐986360), a c‐Jun N‐terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants | Safety, Pharmacokinetics, and Pharmacodynamics of CC‐90001 (BMS‐986360), a c‐Jun N‐terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants Abstract Abstract CC‐90001 selectively inhibits c‐Jun N‐terminal kinase (JNK), a stress‐activated protein implicated in fibrosis. In 3 phase 1 trials evaluating CC‐900... |
PMC6372542 | core_pubmed_pmc | Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults | Sertraline Pharmacokinetics in HIV-Infected and Uninfected Children, Adolescents, and Young Adults Abstract Objective: Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of se... |
PMC9071858 | core_pubmed_pmc | Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong'an Decoction | Comparative Pharmacokinetics of Seven Major Compounds in Normal and Atherosclerosis Mice after Oral Administration of Simiao Yong'an Decoction Abstract Simiao Yong'an decoction (SMYAD), a classic traditional Chinese medicine formula, has been used to treat atherosclerosis (AS) in clinical in China, but its therapeutic ... |
PMC9624268 | core_pubmed_pmc | Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies | Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies Abstract Abstract Purpose Complement alternative pathway (AP) dysregulation has been implicated in geographic atrophy, an advanced form of age-related macular degeneration. Danicopan is an inv... |
PMC3978926 | core_pubmed_pmc | Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study | Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study Abstract Introduction Type I interferons (IFNs) are implicated in the pathogenesis of systemic sclerosis (SSc). MEDI-546 is an investigational human monoclonal a... |
PMC7484796 | core_pubmed_pmc | QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC-Fluorescence detection method | QbD based Eudragit coated Meclizine HCl immediate and extended release multiparticulates: formulation, characterization and pharmacokinetic evaluation using HPLC-Fluorescence detection method Abstract This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and i... |
PMC7060030 | core_pubmed_pmc | Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study | Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study Abstract Abstract Objective This study aimed to quantify the amount of perindopril and its active metabolite perindoprilat present in breast milk and corresponding maternal and infant plasma concentrations. Desi... |
PMC12114802 | core_pubmed_pmc | 5-Fluorouracil Toxicity: Revisiting the Relevance of Pharmacokinetic Parameters | 5-Fluorouracil Toxicity: Revisiting the Relevance of Pharmacokinetic Parameters Abstract Abstract Background/Objectives : 5-fluorouracil (5-FU) is used in the treatment of solid cancer types. Because of its narrow therapeutic window, drug monitoring is recommended. We were confronted to answer a question on the relevan... |
PMC11740529 | core_pubmed_pmc | Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study | Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study Abstract Abstract Background Invasive pulmonary aspergillosis (IPA) is a common opportunistic infection in patients with severe liver disease (SLD), which increases the mortality... |
PMC11945117 | core_pubmed_pmc | Evaluation of Complex Drug Interactions Between Elexacaftor-Tezacaftor-Ivacaftor and Statins Using Physiologically Based Pharmacokinetic Modeling | Evaluation of Complex Drug Interactions Between Elexacaftor-Tezacaftor-Ivacaftor and Statins Using Physiologically Based Pharmacokinetic Modeling Abstract Abstract Background/Objectives: The increasing use of statins in people with cystic fibrosis (CF) necessitates the investigation of potential drug–drug interactions ... |
PMC10864933 | core_pubmed_pmc | Assessment of CYP3A‐mediated drug interaction via cytokine (IL‐6) elevation for mosunetuzumab using physiologically‐based pharmacokinetic modeling | Assessment of CYP3A‐mediated drug interaction via cytokine (IL‐6) elevation for mosunetuzumab using physiologically‐based pharmacokinetic modeling Abstract Abstract Mosunetuzumab is a CD3/CD20 bispecific antibody. As an on‐target effect, transient elevation of interleukin‐6 (IL‐6) occurs in early treatment cycles. A ph... |
PMC6925819 | core_pubmed_pmc | Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study | Simultaneous Determination of Schisandrin and Promethazine with Its Metabolite in Rat Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study Abstract Abstract This study aimed to develop a selective, simple, and sensitive HPLC-MS/MS method for the simultaneous determination of schisandrin and promethazine ... |
PMC11544005 | core_pubmed_pmc | Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia | Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia Abstract Purpose Lefamulin is the first pleuromutilin antibiotic approved for the treatment of community-acquired bacterial pneumonia (CABP). Howe... |
PMC6374537 | core_pubmed_pmc | Prolonged Stupor in Perampanel Overdose and Pharmacokinetic Considerations | Prolonged Stupor in Perampanel Overdose and Pharmacokinetic Considerations Abstract Abstract Perampanel is a new antiepileptic drug with a long half-life, but there are currently no data on the effects of acute perampanel overdose in epilepsy patients. We report a patient who had such an overdose. A 39-year-old woman w... |
PMC3840412 | core_pubmed_pmc | Tumor Quantification in Clinical Positron Emission Tomography | Tumor Quantification in Clinical Positron Emission Tomography Abstract Positron emission tomography (PET) is used extensively in clinical oncology for tumor detection, staging and therapy response assessment. Quantitative measurements of tumor uptake, usually in the form of standardized uptake values (SUVs), have enhan... |
PMC12036903 | core_pubmed_pmc | Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage | Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage Abstract Abstract Purpose This study seeks to reassess and enhance the dosing strategies of letermovir and maribavir for treating cytomegalovirus (CMV) infection, aiming to propose adjustments that could ... |
PMC6767398 | core_pubmed_pmc | Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model | Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model Abstract Abstract Although midazolam is a frequently used sedative in neonatal intensive care units, its use in preterm neonates has been off‐label. Recently, a new dosing advice for midazolam for ... |
PMC10839346 | core_pubmed_pmc | Filtration and tubular handling of EWE‐hC3Nb1, a complement inhibitor nanobody, in wild type mice and a mouse model of proteinuric kidney disease | Filtration and tubular handling of EWE‐hC3Nb1, a complement inhibitor nanobody, in wild type mice and a mouse model of proteinuric kidney disease Abstract Abstract Tubular activation and deposition of filtered complement proteins have been implicated in the progression of proteinuric kidney disease. The potent C3b‐spec... |
PMC9650263 | core_pubmed_pmc | Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro , pharmacokinetic, and in-silico studies | Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro , pharmacokinetic, and in-silico studies Abstract Hepatocellular carcinoma (HCC) is a common malignancy which affects a substantial number of individuals all over the globe. It is the third ... |
PMC5741962 | core_pubmed_pmc | Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats | Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats Abstract Abstract Background This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma... |
PMC11885104 | core_pubmed_pmc | Alternative dosing regimens of GLP ‐1 receptor agonists may reduce costs and maintain weight loss efficacy | Alternative dosing regimens of GLP ‐1 receptor agonists may reduce costs and maintain weight loss efficacy Abstract Abstract Aims To discover alternative dosing regimens of incretin mimetics that simultaneously reduce costs and maintain weight loss efficacy. As a secondary objective, we used our results to explore how ... |
PMC8456861 | core_pubmed_pmc | Anti‐interleukin‐6 antibody clazakizumab in late antibody‐mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism | Anti‐interleukin‐6 antibody clazakizumab in late antibody‐mediated kidney transplant rejection: effect on cytochrome P450 drug metabolism Abstract Summary Targeting interleukin‐6 (IL‐6) is a promising strategy to counteract antibody‐mediated rejection (ABMR). In inflammatory states, IL‐6 antagonism was shown to modulat... |
PMC5388234 | core_pubmed_pmc | Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl | Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl Abstract Abstract To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challen... |
PMC10250603 | core_pubmed_pmc | Development of a population pharmacokinetic model of pyrazinamide to guide personalized therapy: impacts of geriatric and diabetes mellitus on clearance | Development of a population pharmacokinetic model of pyrazinamide to guide personalized therapy: impacts of geriatric and diabetes mellitus on clearance Abstract Objectives: This study was performed to develop a population pharmacokinetic model of pyrazinamide for Korean tuberculosis (TB) patients and to explore and id... |
PMC3169584 | core_pubmed_pmc | A Randomized, Placebo Controlled, Double Masked Phase IB Study Evaluating the Safety and Antiviral Activity of Aprepitant, a Neurokinin-1 Receptor Antagonist in HIV-1 Infected Adults | A Randomized, Placebo Controlled, Double Masked Phase IB Study Evaluating the Safety and Antiviral Activity of Aprepitant, a Neurokinin-1 Receptor Antagonist in HIV-1 Infected Adults Abstract Background Neurokinin-1 receptor (NK1R) antagonists have anti-HIV activity in monocyte-derived macrophages, decrease CCR5 expres... |
PMC8418509 | core_pubmed_pmc | The biotin interference within interference suppressed immunoassays | The biotin interference within interference suppressed immunoassays Abstract Abstract Background Reports of false laboratory findings due to a biotin supplementation have raised concerns about the safety of immunoassays. According to current research, biotin is known to cause interference in immunoassays. Since up to 7... |
PMC5625159 | core_pubmed_pmc | Higher patient satisfaction with antidepressants correlates with earlier drug release dates across online user‐generated medical databases | Higher patient satisfaction with antidepressants correlates with earlier drug release dates across online user‐generated medical databases Abstract Abstract Studies establishing the use of new antidepressants often rely simply on proving efficacy of a new compound, comparing against placebo and single compound. The adv... |
PMC8572285 | core_pubmed_pmc | Pharmacokinetics and Safety of Intravenous and Subcutaneous Auto-injector Single-dose Belimumab in Healthy Chinese Volunteers: A phase 1, Randomized, Open-label Study | Pharmacokinetics and Safety of Intravenous and Subcutaneous Auto-injector Single-dose Belimumab in Healthy Chinese Volunteers: A phase 1, Randomized, Open-label Study Abstract Introduction Belimumab is a recombinant human immunoglobulin G1λ monoclonal antibody indicated as an intravenous (IV) 10 mg/kg and subcutaneous ... |
PMC4273092 | core_pubmed_pmc | Excessive Labeling Technique Provides a Highly Sensitive Fluorescent Probe for Real-time Monitoring of Biodegradation of Biopolymer Pharmaceuticals in vivo | Excessive Labeling Technique Provides a Highly Sensitive Fluorescent Probe for Real-time Monitoring of Biodegradation of Biopolymer Pharmaceuticals in vivo Abstract Recombinant proteins represent a large sector of the biopharma market. Determination of the main elimination pathways raises the opportunities to significa... |
PMC11847841 | core_pubmed_pmc | The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy | The development and evaluation of a tublysine-based antibody-drug conjugate with enhanced tumor therapeutic efficacy Abstract Abstract Antibody-drug conjugates (ADCs) offer targeted cancer therapy by delivering cytotoxic agents directly to tumor cells. However, challenges such as relapse, resistance, and diverse patien... |
PMC6994454 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N -Acetyl- p -Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women | Physiologically Based Pharmacokinetic Modeling to Characterize Acetaminophen Pharmacokinetics and N -Acetyl- p -Benzoquinone Imine (NAPQI) Formation in Non-Pregnant and Pregnant Women Abstract Abstract Background and Objective Little is known about acetaminophen (paracetamol) pharmacokinetics during pregnancy. The aim ... |
PMC3711369 | core_pubmed_pmc | A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis | A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis Abstract Objective Etrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retentio... |
PMC4384399 | core_pubmed_pmc | The predictive performance of infusion strategy nomogram based on a fluid kinetic model | The predictive performance of infusion strategy nomogram based on a fluid kinetic model Abstract Abstract Background In a previous study, fluid kinetic models were applied to describe the volume expansion of the fluid space by administration of crystalloid and colloid solutions. However, validation of the models were n... |
PMC7762809 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Modelling of Creatinine‐Drug Interactions in the Chronic Kidney Disease Population | Physiologically‐Based Pharmacokinetic Modelling of Creatinine‐Drug Interactions in the Chronic Kidney Disease Population Abstract Abstract Elevated serum creatinine (S Cr ) caused by the inhibition of renal transporter(s) may be misinterpreted as kidney injury. The interpretation is more complicated in patients with ch... |
PMC11970364 | core_pubmed_pmc | Unraveling PPARβ/δ nuclear receptor agonists via a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation | Unraveling PPARβ/δ nuclear receptor agonists via a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation Abstract Abstract Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors with a crucial regulat... |
PMC4560515 | core_pubmed_pmc | Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime | Pharmacokinetic and nephroprotective benefits of using Schisandra chinensis extracts in a cyclosporine A-based immune-suppressive regime Abstract Cyclosporine A (CsA) is a powerful immunosuppressive drug. However, nephrotoxicity resulting from its long-term usage has hampered its prolonged therapeutic usage. Schisandra... |
PMC7894426 | core_pubmed_pmc | Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism | Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism Abstract Abstract Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and po... |
PMC4737322 | core_pubmed_pmc | Clinical pharmacokinetic properties of magnesium sulphate in women with pre‐eclampsia and eclampsia | Clinical pharmacokinetic properties of magnesium sulphate in women with pre‐eclampsia and eclampsia Abstract Abstract Background The pharmacokinetic basis of magnesium sulphate (MgSO 4 ) dosing regimens for eclampsia prophylaxis and treatment is not clearly established. Objectives To review available data on clinical p... |
PMC10092186 | core_pubmed_pmc | Effect of the human endotoxin challenge on tedizolid tissue penetration | Effect of the human endotoxin challenge on tedizolid tissue penetration Abstract The effects of the human endotoxin challenge on tissue pharmacokinetics are unknown. In the present study, we aimed to assess the effect of the endotoxin challenge on interstitial fluid pharmacokinetics of tedizolid in healthy volunteers u... |
PMC12627003 | core_pubmed_pmc | Mylabris: a review of its biological characteristics, chemical composition, pharmacological, toxicology, pharmacokinetics, and marketed drugs | Mylabris: a review of its biological characteristics, chemical composition, pharmacological, toxicology, pharmacokinetics, and marketed drugs Abstract Ethnopharmacological relevance Mylabris (“斑蝥’’), derived from the dried bodies of the Chinese blister beetles Mylabris phalerata Pallas and Mylabris cichorii Linnaeus, w... |
PMC12868593 | core_pubmed_pmc | Direct Oral Anticoagulants for Portal Vein Thrombosis in Cirrhosis: From Pharmacology to Clinical Practice | Direct Oral Anticoagulants for Portal Vein Thrombosis in Cirrhosis: From Pharmacology to Clinical Practice Abstract Background Hemostasis in cirrhosis is a dynamic, “rebalanced” state rather than a simple bleeding diathesis. Portal vein thrombosis (PVT) is a frequent complication linked to variceal bleeding, hepatic de... |
PMC6320949 | core_pubmed_pmc | Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics | Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics Abstract Abstract (1) Background: Monoclonal antibodies are used in the treatment of multiple conditions including cancer, autoimmune disorders, and infectious diseases. One of the initial steps in the selection of... |
PMC7373715 | core_pubmed_pmc | A semi‐mechanistic model based on glutathione depletion to describe intra‐individual reduction in busulfan clearance | A semi‐mechanistic model based on glutathione depletion to describe intra‐individual reduction in busulfan clearance Abstract Abstract Aim To develop a semi‐mechanistic model, based on glutathione depletion and predict a previously identified intra‐individual reduction in busulfan clearance to aid in more precise dosin... |
PMC8804165 | core_pubmed_pmc | Contraceptive effectiveness, pharmacokinetics, and safety of Sayana® Press when injected every four months: a multicenter phase 3 trial | Contraceptive effectiveness, pharmacokinetics, and safety of Sayana® Press when injected every four months: a multicenter phase 3 trial Abstract Summary Background Sayana Press® is a 3-monthly contraceptive injection approved by regulatory agencies in more than 40 countries worldwide. Existing effectiveness and pharmac... |
PMC8037385 | core_pubmed_pmc | Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform | Accelerated Repurposing and Drug Development of Pulmonary Hypertension Therapies for COVID-19 Treatment Using an AI-Integrated Biosimulation Platform Abstract The COVID-19 pandemic has reached over 100 million worldwide. Due to the multi-targeted nature of the virus, it is clear that drugs providing anti-COVID-19 effec... |
PMC10609026 | core_pubmed_pmc | Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review | Spectrum–Effect Relationships as an Effective Approach for Quality Control of Natural Products: A Review Abstract As natural products with biological activity, the quality of traditional Chinese medicines (TCM) is the key to their clinical application. Fingerprints based on the types and contents of chemical components... |
PMC12948181 | core_pubmed_pmc | Dual Repurposing Strategy: Rivaroxaban and Ciprofloxacin as a Synergistic Anticancer Therapy in Cervical Cancer: Insight into Inhibition of Metastasis via Targeting the EMT Pathway | Dual Repurposing Strategy: Rivaroxaban and Ciprofloxacin as a Synergistic Anticancer Therapy in Cervical Cancer: Insight into Inhibition of Metastasis via Targeting the EMT Pathway Abstract Objective: This study assessed the anticancer and antimetastatic impact of rivaroxaban-ciprofloxacin mixture and explored its mole... |
PMC4375292 | core_pubmed_pmc | Chronopharmacokinetics of once daily dosed aminoglycosides in hospitalized infectious patients | Chronopharmacokinetics of once daily dosed aminoglycosides in hospitalized infectious patients Abstract Abstract Background hospitalized patients with serious infections treated with aminoglycosides are at risk of developing nephrotoxicity. Previous clinical studies have shown that the pharmacokinetics of aminoglycosid... |
PMC7810610 | core_pubmed_pmc | Impact of Dose Reduction on Efficacy: Implications of Exposure-Response Analysis of Palbociclib | Impact of Dose Reduction on Efficacy: Implications of Exposure-Response Analysis of Palbociclib Abstract Abstract Background Palbociclib is indicated for hormone receptor–positive, human epidermal growth factor receptor 2–negative advanced breast cancer (ABC). Objective Exposure-response analyses were conducted to eval... |
PMC12616583 | core_pubmed_pmc | Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma | Self‐Assembling Multi‐Antigen T Cell Hybridizers for Precision Immunotherapy of Multiple Myeloma Abstract Abstract Bispecific T‐cell engagers show promise in treating multiple myeloma (MM), but challenges remain in adaptability and targeting flexibility. This paper presents a novel T‐cell based immunotherapy, M ulti‐ A... |
PMC8859640 | core_pubmed_pmc | Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study | Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study Abstract Abstract Aims In pre-clinical models of acute myocardial infarction (MI), mature B cells mobilize inflammatory monocytes into the heart, leading to increased infarct size and deterioration of cardiac func... |
PMC12741130 | core_pubmed_pmc | Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review | Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review Abstract Introduction Chlorpheniramine maleate (CPM) is a first-generation H1-antihistamine widely used for allergic conditions, yet its pharmacokinetic (PK) and bioavailability profiles across... |
PMC11207871 | core_pubmed_pmc | Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations | Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations Abstract Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also k... |
PMC9784748 | core_pubmed_pmc | The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach | The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of the Grewia tenax Fruit Extract: In Vivo and Ex Vivo Approach Abstract Abstract The study was performed to assess and rationalize the traditional utilization of the fruit part of Grewia tenax ( G . tenax ). The phytoconstituents present in th... |
PMC12260924 | core_pubmed_pmc | Pharmacokinetics of Dual Amino Acids for Dry Powder Inhalation Therapy in Pulmonary Drug Delivery: An In-Vivo Study | Pharmacokinetics of Dual Amino Acids for Dry Powder Inhalation Therapy in Pulmonary Drug Delivery: An In-Vivo Study Abstract Abstract Background: Smoking cigarettes leads to serious health problems, and addiction is a major concern. De-addiction therapy includes e-cigarettes and counseling, and the success rate is poor... |
PMC9310564 | core_pubmed_pmc | Vericiguat in Combination with Short‐Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study | Vericiguat in Combination with Short‐Acting Nitroglycerin in Patients With Chronic Coronary Syndromes: The Randomized, Phase Ib, VENICE Study Abstract Abstract Vericiguat is a soluble guanylate cyclase stimulator indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization in adults with ... |
PMC10224943 | core_pubmed_pmc | Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives | Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives Abstract A large number of new synthetic compounds are synthesized in the field of heterocyclic chemistry having a variety of biological potentials. In the present study, some synthetic indole de... |
PMC9662198 | core_pubmed_pmc | A multi‐model approach to predict efficacious clinical dose for an anti‐TGF ‐β antibody ( GC2008 ) in the treatment of osteogenesis imperfecta | A multi‐model approach to predict efficacious clinical dose for an anti‐TGF ‐β antibody ( GC2008 ) in the treatment of osteogenesis imperfecta Abstract Abstract Osteogenesis imperfecta (OI) is a heterogeneous group of inherited bone dysplasias characterized by reduced skeletal mass and bone fragility. Although the prim... |
PMC11773105 | core_pubmed_pmc | Applying the estimand framework to clinical pharmacology trials with a case study in bioequivalence | Applying the estimand framework to clinical pharmacology trials with a case study in bioequivalence Abstract The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use has published an addendum on estimands and sensitivity analysis in clinical trials along with related train... |
PMC11201243 | core_pubmed_pmc | Optimizing Antibiotic Therapy for Stenotrophomonas maltophilia Infections in Critically Ill Patients: A Pharmacokinetic/Pharmacodynamic Approach | Optimizing Antibiotic Therapy for Stenotrophomonas maltophilia Infections in Critically Ill Patients: A Pharmacokinetic/Pharmacodynamic Approach Abstract Stenotrophomonas maltophilia is an opportunistic, multidrug-resistant non-fermentative Gram-negative bacillus, posing a significant challenge in clinical treatment du... |
PMC5054907 | core_pubmed_pmc | Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL | Bioequivalence and comparative pharmacodynamics of insulin lispro 200 U/mL relative to insulin lispro (Humalog®) 100 U/mL Abstract Abstract Insulin lispro 200 U/mL (IL200) is a new strength formulation of insulin lispro (Humalog®, IL100), developed as an option for diabetic patients on higher daily mealtime insulin dos... |
PMC8892701 | core_pubmed_pmc | An open-label phase 2 trial to assess the efficacy, safety and pharmacokinetics of lanthanum carbonate in hyperphosphatemic children and adolescents with chronic kidney disease undergoing dialysis | An open-label phase 2 trial to assess the efficacy, safety and pharmacokinetics of lanthanum carbonate in hyperphosphatemic children and adolescents with chronic kidney disease undergoing dialysis Abstract Background This study assessed the efficacy, tolerability and pharmacokinetics (PK) of lanthanum carbonate (LC) in... |
PMC11436582 | core_pubmed_pmc | Design, pharmacokinetic, and pharmacodynamic evaluation of a lecithin-chitosan hybrid nanoparticle-loaded dual-responsive in situ gel of nebivolol for effective treatment of glaucoma | Design, pharmacokinetic, and pharmacodynamic evaluation of a lecithin-chitosan hybrid nanoparticle-loaded dual-responsive in situ gel of nebivolol for effective treatment of glaucoma Abstract Abstract In this research work, optimized nebivolol-loaded lecithin-chitosan hybrid nanoparticles (NEB-LCNPs) were prepared usin... |
PMC5856894 | core_pubmed_pmc | Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review | Asenapine Treatment in Pediatric Patients with Bipolar I Disorder or Schizophrenia: A Review Abstract Abstract Asenapine, administered as a twice-daily (BID) sublingual tablet, is approved in the US as monotherapy for the acute treatment of manic and mixed episodes of bipolar I disorder in children and adolescents aged... |
PMC11392870 | core_pubmed_pmc | Clinical challenges in the dosing and titration of cariprazine | Clinical challenges in the dosing and titration of cariprazine Abstract Abstract The introduction of a new psychopharmaceutical medication instead of the previous one always poses a certain challenge. In the case of antipsychotics (AP), these problems are considerably more complicated and are mainly caused by the quest... |
PMC12050361 | core_pubmed_pmc | Population pharmacokinetics and exposure‐response relationship for temsavir following fostemsavir administration in treatment‐experienced HIV patients | Population pharmacokinetics and exposure‐response relationship for temsavir following fostemsavir administration in treatment‐experienced HIV patients Abstract Abstract Fostemsavir (FTR, GSK3684934; formerly BMS‐663068) is a human immunodeficiency virus type 1 (HIV‐1) attachment inhibitor approved for the treatment of ... |
PMC12162884 | core_pubmed_pmc | Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation | Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation Abstract IgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives i... |
PMC8365693 | core_pubmed_pmc | The emergence of imaging mass spectrometry in drug discovery and development: Making a difference by driving decision making | The emergence of imaging mass spectrometry in drug discovery and development: Making a difference by driving decision making Abstract Abstract The pharmaceutical industry is a dynamic, science‐driven business constantly under pressure to innovate and morph into a higher performing organization. Innovations can include ... |
PMC5643367 | core_pubmed_pmc | Pharmacokinetics of Cromolyn and Ibuprofen in Healthy Elderly Volunteers | Pharmacokinetics of Cromolyn and Ibuprofen in Healthy Elderly Volunteers Abstract Background and Objectives The combination of cromolyn and ibuprofen is being investigated as a treatment for early Alzheimer’s disease (AD). This study investigated the pharmacokinetics, safety, and tolerability of cromolyn and ibuprofen ... |
PMC12107366 | core_pubmed_pmc | Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography | Pharmacokinetic analysis on compatibility of Atractylodes macrocephala and Paeoniae radix herb pair ameliorates functional constipation model rats using microdialysis with ultra‐performance liquid chromatography Abstract Abstract Background In a previous study, we found that Atractylodes macrocephala and Paeoniae radix... |
PMC11676693 | core_pubmed_pmc | Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors | Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors Abstract Abstract Background/Objectives: Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 ( NCT02255461 ; PBT... |
PMC8932719 | core_pubmed_pmc | To blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias | To blind or not to blind first in human and exploratory clinical trials: Acceleration of development vs. risk of bias Abstract Abstract An IQ consortium working group (WG) conducted a survey across multiple biopharmaceutical companies to gain information about the level of blinding commonly utilized for early clinical ... |
PMC9841305 | core_pubmed_pmc | First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2 | First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2 Abstract Abstract This randomized, double‐blind, single‐ and multiple‐ascending dose study assessed the pharmacokinetics (PKs), pharmacodynamics, and safety of deucravacitinib (Sotyktu™), a selective a... |
PMC11700039 | core_pubmed_pmc | Landscape analysis of adverse events and dose intensity for FDA approved oncology small molecules | Landscape analysis of adverse events and dose intensity for FDA approved oncology small molecules Abstract As development of new oncology small molecule therapies is focused mainly on molecularly targeted agents, the dose selection paradigm has shifted from the maximum tolerated dose (MTD)-based approach traditionally ... |
PMC4310350 | core_pubmed_pmc | Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide | Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide Abstract Abstract We investigated the in vitro transport characteristics of catalposide in HEK293 cells overexpressing organic anion transporter 1 (OAT1), OAT3, organic anion transporting polypeptide ... |
PMC6088255 | core_pubmed_pmc | Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats | Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats Abstract Abstract Purpose: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges follow... |
PMC4832912 | core_pubmed_pmc | Forensic pharmacology: An important and evolving subspecialty needs recognition in India | Forensic pharmacology: An important and evolving subspecialty needs recognition in India Abstract With training in pharmacology, a pharmacologist has an expert knowledge as well as working experience in the subjects of therapeutics, pharmacokinetics, and toxicology along with exposure to subjects such as forensic medic... |
PMC5784735 | core_pubmed_pmc | Crowdsourced Asparagus Urinary Odor Population Kinetics | Crowdsourced Asparagus Urinary Odor Population Kinetics Abstract Abstract The consumption of asparagus is associated with the production of malodorous urine with considerable interindividual variability (IIV). To characterize the urinary odor kinetics after consumption of asparagus spears, we conducted a study with con... |
PMC4405571 | core_pubmed_pmc | Quality of Antimicrobial Products Used in Striped Catfish ( Pangasianodon hypophthalmus ) Aquaculture in Vietnam | Quality of Antimicrobial Products Used in Striped Catfish ( Pangasianodon hypophthalmus ) Aquaculture in Vietnam Abstract Abstract Antimicrobial usage is common in Asian aquaculture. This study aimed to determine the quality of antimicrobial products used by Vietnamese striped catfish ( Pangasianodon hypophthalmus ) fa... |
PMC11178671 | core_pubmed_pmc | Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer | Preclinical evaluation of EpCAM-binding designed ankyrin repeat proteins (DARPins) as targeting moieties for bimodal near-infrared fluorescence and photoacoustic imaging of cancer Abstract Purpose Fluorescence-guided surgery (FGS) can play a key role in improving radical resection rates by assisting surgeons to gain ad... |
PMC12495659 | core_pubmed_pmc | An ADR pharmaceutical care for severe gastrointestinal bleeding of rivaroxaban in a patient with nonvalvular atrial fibrillation based on TDM and genetic testing: a case report | An ADR pharmaceutical care for severe gastrointestinal bleeding of rivaroxaban in a patient with nonvalvular atrial fibrillation based on TDM and genetic testing: a case report Abstract Abstract Background Due to its predictable pharmacodynamics and pharmacokinetics, stable blood concentration, and relatively short hal... |
PMC8807537 | core_pubmed_pmc | Nanobodies Are Potential Therapeutic Agents for the Ebola Virus Infection | Nanobodies Are Potential Therapeutic Agents for the Ebola Virus Infection Abstract Abstract Ebola fever is an acute, highly contagious viral disease with a mortality rate that can reach 90%. There are currently no licensed therapeutic agents specific to Ebola in the world. Monoclonal antibodies (MAbs) with viral-neutra... |
PMC11549138 | core_pubmed_pmc | Whole Body Physiologically Based Pharmacokinetic Model to Explain A Patient With Drug–Drug Interaction Between Voriconazole and Flucloxacillin | Whole Body Physiologically Based Pharmacokinetic Model to Explain A Patient With Drug–Drug Interaction Between Voriconazole and Flucloxacillin Abstract Abstract Background and Objectives Voriconazole administered concomitantly with flucloxacillin may result in subtherapeutic plasma concentrations as shown in a patient ... |
PMC10142100 | core_pubmed_pmc | Characteristics of Seltorexant—Innovative Agent Targeting Orexin System for the Treatment of Depression and Anxiety | Characteristics of Seltorexant—Innovative Agent Targeting Orexin System for the Treatment of Depression and Anxiety Abstract Twenty-five years have passed since the discovery of the orexin system, during which time we have learned more and more about it. A number of studies have been conducted showing the role of the o... |
PMC6624958 | core_pubmed_pmc | A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice | A non-lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice Abstract Background Given the central importance of anti-malarial drugs in the treatment of malaria, there is a need to understand the effect of Plasmodium infection on the broad spectrum of drug metabolizi... |
PMC9318133 | core_pubmed_pmc | In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice | In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice Abstract Abstract 3-(1-Naphthalenylmethyl)-1-pentyl-1H-indole (JWH-175) is a synthetic cannabinoid illegally marketed for its psychoactive cannabis-like effects. This study aimed to investigate and compare in vitro and in ... |
PMC12109360 | core_pubmed_pmc | Molecular Ancestry Across Allelic Variants of SLC22A1 , SLC22A2 , SLC22A3 , ABCB1 , CYP2C8 , CYP2C9 , and CYP2C19 in Mexican-Mestizo DMT2 Patients | Molecular Ancestry Across Allelic Variants of SLC22A1 , SLC22A2 , SLC22A3 , ABCB1 , CYP2C8 , CYP2C9 , and CYP2C19 in Mexican-Mestizo DMT2 Patients Abstract Abstract Background/Aims : across protein-coding genes, single nucleotide allelic variants (SNVs) affect antidiabetic drug pharmacokinetics, thus contributing to in... |
PMC12853748 | core_pubmed_pmc | Preliminary clinical evaluation of cefmetazole dosing regimens in Japanese patients with urinary tract infections | Preliminary clinical evaluation of cefmetazole dosing regimens in Japanese patients with urinary tract infections Abstract Background Cefmetazole (CMZ) is widely used in Japan to treat infections such as urinary tract infections (UTIs), intra-abdominal infections, and bloodstream infections. However, pharmacokinetic an... |
PMC12425334 | core_pubmed_pmc | Exploring Dolichos lablab compounds as potential inhibitors for fusion (F) protein of human metapneumovirus (HMPV): A systematic computational approach | Exploring Dolichos lablab compounds as potential inhibitors for fusion (F) protein of human metapneumovirus (HMPV): A systematic computational approach Abstract Abstract One of the most crucial respiratory pathogens in the world, namely human metapneumovirus (HMPV), causes acute upper and lower respiratory tract infect... |
PMC8504814 | core_pubmed_pmc | Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer | Safety and pharmacokinetics of docetaxel in combination with pegvorhyaluronidase alfa in patients with non‐small cell lung cancer Abstract Abstract This open‐label, phase Ib study ( NCT02346370 ) assessed the effect of pegvorhyaluronidase alfa (PVHA; PEGPH20) on the plasma pharmacokinetics (PKs) and safety of docetaxel... |
PMC5067149 | core_pubmed_pmc | Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations | Pharmacogenetic tests for antipsychotic medications: clinical implications and considerations Abstract Optimizing antipsychotic pharmacotherapy is often challenging due to significant variability in effectiveness and tolerability. Genetic factors influencing pharmacokinetics and pharmacodynamics may contribute to some ... |
PMC4331089 | core_pubmed_pmc | Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha | Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha Abstract Abstract Interferon alpha (IFNα) is used for the treatment of hepatitis B virus infection, and whilst efficacious, it is associated with multiple adverse events caused by systemic exposure ... |
PMC9916042 | core_pubmed_pmc | Transplacental Therapeutic Drug Monitoring in Pregnant Women with Fetal Tachyarrhythmia Using HPLC-MS/MS | Transplacental Therapeutic Drug Monitoring in Pregnant Women with Fetal Tachyarrhythmia Using HPLC-MS/MS Abstract Abstract Fetal arrhythmia develops in 0.1–5% of pregnancies and may cause fetal heart failure and fetal hydrops, thus increasing fetal, neonatal, and infant mortality. The timely initiation of transplacenta... |
PMC3713315 | core_pubmed_pmc | The Role of Phenytoin in the Treatment of Localization Related Epilepsy: An International Internet-Based Survey of Neurologists and Epileptologists | The Role of Phenytoin in the Treatment of Localization Related Epilepsy: An International Internet-Based Survey of Neurologists and Epileptologists Abstract Abstract Phenytoin (PHT) has been the most widely used medication to treat both partial and generalized seizures. However, over the past twenty years, a variety of... |
PMC9159578 | core_pubmed_pmc | Scalable and flexible inference framework for stochastic dynamic single-cell models | Scalable and flexible inference framework for stochastic dynamic single-cell models Abstract Understanding the inherited nature of how biological processes dynamically change over time and exhibit intra- and inter-individual variability, due to the different responses to environmental stimuli and when interacting with ... |
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