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PMC10116519 | core_pubmed_pmc | Prediction for Plasma Trough Concentration and Optimal Dosing of Imatinib under Multiple Clinical Situations Using Physiologically Based Pharmacokinetic Modeling | Prediction for Plasma Trough Concentration and Optimal Dosing of Imatinib under Multiple Clinical Situations Using Physiologically Based Pharmacokinetic Modeling Abstract (1) Purpose : This study aimed to develop a physiologically based pharmacokinetic (PBPK) model to predict the trough concentration ( C trough ) of im... |
PMC9617823 | core_pubmed_pmc | Effect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects | Effect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects Abstract Background and Objectives Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to ev... |
PMC8953816 | core_pubmed_pmc | Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) | Enhancement of the Solubility and Bioavailability of Pitavastatin through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) Abstract The purpose of the study was to develop an SNEDDS to improve the solubility and bioavailability of pitavastatin. The solubility of pitavastatin in different oils, surfactants, and co-s... |
PMC11043191 | core_pubmed_pmc | A Modified Delphi Study to Establish Essential Clinical Pharmacology Competencies | A Modified Delphi Study to Establish Essential Clinical Pharmacology Competencies Abstract Abstract Introduction Competency-based education has been commonly used to enhance the healthcare workforce for some time. A translational discipline that is integral to drug development and impactful on healthcare and public hea... |
PMC9340768 | core_pubmed_pmc | Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology | Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology Abstract Abstract CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based... |
PMC4614130 | core_pubmed_pmc | Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans | Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans Abstract Abnormal dopaminergic modulation of connectivity between the putamen and cortex is thought to underlie the emergence of levodopa-induced dyskinesias. Herz et al . confirm this directly by showing that... |
PMC12584216 | core_pubmed_pmc | A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion | A 3D non-human primate digital model for pharmacokinetic prediction of intra-cerebrospinal fluid drug neuraxial dispersion Abstract Abstract Background Intra-cerebrospinal fluid (CSF) drug delivery bypasses the blood-brain barrier, making it a promising route of delivery to treat central nervous system (CNS) diseases. ... |
PMC9099132 | core_pubmed_pmc | A phase I evaluation of the effect of curcumin on dose‐limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors | A phase I evaluation of the effect of curcumin on dose‐limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors Abstract Abstract Curcumin inhibits UDP‐glucuronyltransferases, a primary metabolic pathway for cancer chemotherapeutic agents like irinotecan. Concurrent administration of both ... |
PMC8982769 | core_pubmed_pmc | Kimyrsa, An Oritavancin-Containing Product: Clinical Study and Review of Properties | Kimyrsa, An Oritavancin-Containing Product: Clinical Study and Review of Properties Abstract Abstract Background There is a need for improved antibiotic formulations for the treatment of acute bacterial skin and soft structure infection (ABSSSI), especially with the rise of antimicrobial resistance among Gram-positive ... |
PMC10867185 | core_pubmed_pmc | Constituents, pharmacological activities, pharmacokinetic studies, clinical applications, and safety profile on the classical prescription Kaixinsan | Constituents, pharmacological activities, pharmacokinetic studies, clinical applications, and safety profile on the classical prescription Kaixinsan Abstract Kaixinsan (KXS) is a noteworthy classical prescription, which consists of four Chinese medicinal herbs, namely Polygalae Radix, Ginseng Radix et Rhizoma, Poria, a... |
PMC8992361 | core_pubmed_pmc | Overcoming Stenotrophomonas maltophilia Resistance for a More Rational Therapeutic Approach | Overcoming Stenotrophomonas maltophilia Resistance for a More Rational Therapeutic Approach Abstract Abstract Stenotrophomonas maltophilia is an underappreciated source of morbidity and mortality among gram-negative pathogens. Effective treatment options with acceptable toxicity profiles are limited. Phenotypic suscept... |
PMC11093219 | core_pubmed_pmc | Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial | Safety, Efficacy, and Pharmacokinetics of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies BMS-986414 (C135-LS) and BMS-986413 (C144-LS) Administered Subcutaneously in Non-Hospitalized Persons with COVID-19 in a Phase 2 Trial Abstract Background: Outpatient COVID-19 monoclonal antibody (mAb) treatment via subc... |
PMC8674127 | core_pubmed_pmc | A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus | A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus Abstract Chikungunya virus (CHIKV) infection causes acute disease characterized by fever, rash and arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients. Moreove... |
PMC11530871 | core_pubmed_pmc | Sex Differences on the Pharmacokinetics of Drugs for Children with Chronic Kidney Disease: A Narrative Review | Sex Differences on the Pharmacokinetics of Drugs for Children with Chronic Kidney Disease: A Narrative Review Abstract Abstract Effective optimal pharmacotherapy requires a comprehensive understanding of the drug’s pharmacokinetic properties. Chronic kidney disease (CKD) influences medication pharmacokinetics. However,... |
PMC3457677 | core_pubmed_pmc | Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery | Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery Abstract Abstract Background The synthetic potential chemotherapeutic agent 3-Chloro-4-[(4-methoxyphenyl) amino]furo[2,3-b]quinoline (PK-L4) is an analog o... |
PMC12209990 | core_pubmed_pmc | Effect of Cytochrome P450 3A Inhibition and Induction by Itraconazole and Rifampin on Tazemetostat Pharmacokinetics in Patients With Advanced Malignancies | Effect of Cytochrome P450 3A Inhibition and Induction by Itraconazole and Rifampin on Tazemetostat Pharmacokinetics in Patients With Advanced Malignancies Abstract Abstract This study ( NCT04537715 ) investigated itraconazole (strong cytochrome P450 [CYP] 3A inhibitor) and rifampin (strong CYP3A inducer) on tazemetosta... |
PMC12434611 | core_pubmed_pmc | Pharmacokinetics and Bioequivalence of Mycophenolate Sodium Enteric-Coated Tablets Under Fasting and Fed Conditions: A Single-Dose, Open-Label, Four-Period Replicated Crossover Study in Healthy Chinese Male Subjects | Pharmacokinetics and Bioequivalence of Mycophenolate Sodium Enteric-Coated Tablets Under Fasting and Fed Conditions: A Single-Dose, Open-Label, Four-Period Replicated Crossover Study in Healthy Chinese Male Subjects Abstract Aim Enteric-coated mycophenolate sodium (EC-MPS) is an immunosuppressant used to prevent organ ... |
PMC9271619 | core_pubmed_pmc | Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version | Better Bioactivity, Cerebral Metabolism and Pharmacokinetics of Natural Medicine and Its Advanced Version Abstract Abstract Currently, many people are afflicted by cerebral diseases that cause dysfunction in the brain and perturb normal daily life of people. Cerebral diseases are greatly affected by cerebral metabolism... |
PMC11055145 | core_pubmed_pmc | Improving Pharmacokinetics of Peptides Using Phage Display | Improving Pharmacokinetics of Peptides Using Phage Display Abstract Abstract Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to ident... |
PMC5539056 | core_pubmed_pmc | Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care | Nebulized antibiotics in mechanically ventilated patients: a challenge for translational research from technology to clinical care Abstract Nebulized antibiotic therapy directly targets airways and lung parenchyma resulting in high local concentrations and potentially lower systemic toxicities. Experimental and clinica... |
PMC9737891 | core_pubmed_pmc | Neuroprotective Effects of the Psychoactive Compound Biatractylolide (BD) in Alzheimer’s Disease | Neuroprotective Effects of the Psychoactive Compound Biatractylolide (BD) in Alzheimer’s Disease Abstract Mitochondria play a central role in the survival or death of neuronal cells, and they are regulators of energy metabolism and cell death pathways. Many studies support the role of mitochondrial dysfunction and oxid... |
PMC9299459 | core_pubmed_pmc | Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants | Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants Abstract Abstract Crizotinib is a small‐molecule, multitargeted tyrosine kinase inhibitor that exhibits decreased aqueous solubility at a higher pH. This open‐label, randomized, phase 1 study (NCT01549574) evaluated ... |
PMC8505310 | core_pubmed_pmc | Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer | Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer Abstract Abstract Purpose To evaluate GT0918, a 2nd-generation AR antagonist, for its AR down-regulation activity among breast cancer patients. Methods The effect of GT0918 on AR protein express... |
PMC7693334 | core_pubmed_pmc | Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models | Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models Abstract Abstract Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic stability is usually assessed in microsomal fractions and only the best compounds progress in the drug discovery process... |
PMC7587198 | core_pubmed_pmc | Protease Inhibitory Effect of Natural Polyphenolic Compounds on SARS-CoV-2: An In Silico Study | Protease Inhibitory Effect of Natural Polyphenolic Compounds on SARS-CoV-2: An In Silico Study Abstract Abstract The current pandemic, caused by SARS-CoV-2 virus, is a severe challenge for human health and the world economy. There is an urgent need for development of drugs that can manage this pandemic, as it has alrea... |
PMC12270941 | core_pubmed_pmc | Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation | Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation Abstract Summary Acute alcohol can have profound effects on the brain and behavior. Dorsal medial prefrontal cortex (dmPFC) function is especially sensitive to disruption from acute alcohol exposure. The acute, bro... |
PMC3643872 | core_pubmed_pmc | A model of HIV drug resistance driven by heterogeneities in host immunity and adherence patterns | A model of HIV drug resistance driven by heterogeneities in host immunity and adherence patterns Abstract Background Population transmission models of antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) use simplistic assumptions – typically constant, homogeneous rates – to represent the short-term risk an... |
PMC7913149 | core_pubmed_pmc | Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies | Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies Abstract Abstract Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C SS,min ENDX ) above 5.97 ng/mL have been ... |
PMC7051932 | core_pubmed_pmc | Clinical Pharmacology of Elagolix: An Oral Gonadotropin-Releasing Hormone Receptor Antagonist for Endometriosis | Clinical Pharmacology of Elagolix: An Oral Gonadotropin-Releasing Hormone Receptor Antagonist for Endometriosis Abstract Abstract The clinical pharmacology of elagolix was extensively evaluated in clinical studies in healthy subjects and in women with endometriosis. Elagolix pharmacokinetics (PK) show significant popul... |
PMC8458697 | core_pubmed_pmc | Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients | Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients Abstract Abstract Purpose: This study was performed to investigate the effects of common polymorphisms in CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects o... |
PMC7873121 | core_pubmed_pmc | Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview | Pharmacokinetic Characteristics of Long-Acting Injectable Antipsychotics for Schizophrenia: An Overview Abstract Abstract The availability of long-acting injectable (LAI) antipsychotics for the treatment of schizophrenia provides clinicians with options that deliver continuous drug exposure and may improve adherence co... |
PMC4863049 | core_pubmed_pmc | Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn's disease | Adalimumab induction and maintenance therapy achieve clinical remission and response in Chinese patients with Crohn's disease Abstract Abstract Background/Aims This was a Phase 2 study ( NCT02015793 ) to evaluate the pharmacokinetics, safety, and efficacy of adalimumab in Chinese patients with Crohn's disease (CD). Met... |
PMC7969932 | core_pubmed_pmc | Population pharmacokinetics and dose optimization of vancomycin in neonates | Population pharmacokinetics and dose optimization of vancomycin in neonates Abstract The pharmacokinetics of vancomycin vary among neonates, and we aimed to conduct population pharmacokinetic analysis to determine the optimal dosage of vancomycin in Korean neonates. From a retrospective chart review, neonates treated w... |
PMC7991039 | core_pubmed_pmc | Adalimumab Biosimilars in the Treatment of Rheumatoid Arthritis: A Systematic Review of the Evidence for Biosimilarity | Adalimumab Biosimilars in the Treatment of Rheumatoid Arthritis: A Systematic Review of the Evidence for Biosimilarity Abstract Abstract Although treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) has significantly improved clinical outcomes in patients with rheumatoid arthritis (RA), many patients... |
PMC7965833 | core_pubmed_pmc | Population pharmacokinetics of letermovir following oral and intravenous administration in healthy participants and allogeneic hematopoietic cell transplantation recipients | Population pharmacokinetics of letermovir following oral and intravenous administration in healthy participants and allogeneic hematopoietic cell transplantation recipients Abstract Abstract Letermovir is indicated for prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant... |
PMC8380488 | core_pubmed_pmc | Safety, Virologic Efficacy, and Pharmacokinetics of CT-P59, a Neutralizing Monoclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Protein: Two Randomized, Placebo-Controlled, Phase I Studies in Healthy Individuals and Patients With Mild SARS-CoV-2 Infection | Safety, Virologic Efficacy, and Pharmacokinetics of CT-P59, a Neutralizing Monoclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Protein: Two Randomized, Placebo-Controlled, Phase I Studies in Healthy Individuals and Patients With Mild SARS-CoV-2 Infection Abstract Purpose Neutralizing antibodies can reduce SAR... |
PMC8149637 | core_pubmed_pmc | Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis | Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis Abstract Abstract Lysergic acid diethylamide (LSD) is a classic psychedelic substance that is used recreationally and investigated in psychiatric research. There are no pharmacogenetic studies on LSD. In vitro metab... |
PMC10385763 | core_pubmed_pmc | Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design | Artificial Intelligence in Pharmaceutical Technology and Drug Delivery Design Abstract Abstract Artificial intelligence (AI) has emerged as a powerful tool that harnesses anthropomorphic knowledge and provides expedited solutions to complex challenges. Remarkable advancements in AI technology and machine learning prese... |
PMC9052773 | core_pubmed_pmc | In silico evidence of antiviral activity against SARS-CoV-2 main protease of oligosaccharides from Porphyridium sp. | In silico evidence of antiviral activity against SARS-CoV-2 main protease of oligosaccharides from Porphyridium sp. Abstract The coronavirus pandemic (COVID-19) has created an urgent need to develop effective strategies for prevention and treatment. In this context, therapies against protease M pro , a conserved viral ... |
PMC6676569 | core_pubmed_pmc | Population pharmacokinetics of sirolimus in pediatric patients with kaposiform hemangioendothelioma: A retrospective study | Population pharmacokinetics of sirolimus in pediatric patients with kaposiform hemangioendothelioma: A retrospective study Abstract Numerous studies have established population pharmacokinetics (PPK) models of sirolimus in various populations. However, a PPK model of sirolimus in Chinese patients with pediatric kaposif... |
PMC7526832 | core_pubmed_pmc | In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile | In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile Abstract Omadacycline is a potent aminomethylcycline with in vitro activity against Gram-positive, Gram-negative, and anaerobic bacteria. Preliminary data demonstrated that omadacycline has in vitro activity a... |
PMC5664587 | core_pubmed_pmc | Revisiting atenolol as a low passive permeability marker | Revisiting atenolol as a low passive permeability marker Abstract Background Atenolol, a hydrophilic beta blocker, has been used as a model drug for studying passive permeability of biological membranes such as the blood–brain barrier (BBB) and the intestinal epithelium. However, the extent of S-atenolol (the active en... |
PMC6175296 | core_pubmed_pmc | Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans | Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8‐Mediated Metabolism of Montelukast in Humans Abstract Abstract The oxidation of montelukast is mainly mediated by cytochrome P450 (CYP) 2C8, but other mechanisms may contribute to its disposition. In healthy volunteers, we investigated the effects of two w... |
PMC12896373 | core_pubmed_pmc | Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults | Repurposing Oxfendazole for Onchocerciasis: Population Pharmacokinetics of a Tablet Formulation in Healthy African Adults Abstract ABSTRACT Global efforts to eliminate onchocerciasis are hampered by the lack of a macrofilaricidal drug capable of killing adult parasites. Oxfendazole, a veterinary anthelminthic, exhibits... |
PMC6585895 | core_pubmed_pmc | Pharmacokinetics‐Pharmacodynamics of High‐Dose Ivermectin with Dihydroartemisinin‐Piperaquine on Mosquitocidal Activity and QT‐Prolongation (IVERMAL) | Pharmacokinetics‐Pharmacodynamics of High‐Dose Ivermectin with Dihydroartemisinin‐Piperaquine on Mosquitocidal Activity and QT‐Prolongation (IVERMAL) Abstract Abstract High‐dose ivermectin, co‐administered for 3 days with dihydroartemisinin‐piperaquine (DP), killed mosquitoes feeding on individuals for at least 28 days... |
PMC10339510 | core_pubmed_pmc | Earth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma | Earth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma Abstract A novel, sensitive, and green micellar UPLC method was proposed and validated for the simultaneous determination of four hypoglycemic agents used in type II diabe... |
PMC6058699 | core_pubmed_pmc | Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats | Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats Abstract Abstract The aim of this study was to formulate granisetron hydrochloride (GH) spanlastic in mucoadhesive gels and lyophilized inserts for intranasal administration to improv... |
PMC5204012 | core_pubmed_pmc | Acinetobacter Prosthetic Joint Infection Treated with Debridement and High-Dose Tigecycline | Acinetobacter Prosthetic Joint Infection Treated with Debridement and High-Dose Tigecycline Abstract Abstract Prosthesis retention is not recommended for multidrug-resistant Acinetobacter prosthetic joint infection due to its high failure rate. Nevertheless, replacing the prosthesis implies high morbidity and prolonged... |
PMC11994481 | core_pubmed_pmc | Lung-Targeted Itraconazole Delivery Using PVA-Based Nano-in-Microparticles for Improved Treatment of Pulmonary Aspergillosis | Lung-Targeted Itraconazole Delivery Using PVA-Based Nano-in-Microparticles for Improved Treatment of Pulmonary Aspergillosis Abstract Abstract Purpose Pulmonary aspergillosis (PA) presents a substantial therapeutic challenge, especially in immunocompromised patients, where conventional systemic treatments like oral and... |
PMC7822074 | core_pubmed_pmc | Long-Term Outcomes of Previously Treated Adult and Adolescent Patients with Severe Hemophilia A Receiving Prophylaxis with Extended Half-Life FVIII Treatments: An Economic Analysis from a United Kingdom Perspective | Long-Term Outcomes of Previously Treated Adult and Adolescent Patients with Severe Hemophilia A Receiving Prophylaxis with Extended Half-Life FVIII Treatments: An Economic Analysis from a United Kingdom Perspective Abstract Background The standard of care for patients with hemophilia A is prophylaxis with factor VIII (... |
PMC8765294 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults Abstract ABSTRACT Despite repeated malaria infection, individuals living in areas where malaria is endemic remain vulnerable to reinfection. The Janus kinase (JAK1/2) inhibitor ruxoli... |
PMC10581202 | core_pubmed_pmc | Subgroup analysis of phase 2 study of ceftolozane/tazobactam in neonates and young infants with pyelonephritis | Subgroup analysis of phase 2 study of ceftolozane/tazobactam in neonates and young infants with pyelonephritis Abstract ABSTRACT Ceftolozane/tazobactam is approved for the treatment of patients from birth to <18 y old with complicated urinary tract infections (cUTI). This post hoc analysis evaluated the safety, efficac... |
PMC8173314 | core_pubmed_pmc | In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis | In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis Abstract Abstract Tuberculosis (TB) continuously poses a major public health concern around the globe, with a mounting death toll of approximately 1.4 million ... |
PMC4500855 | core_pubmed_pmc | Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review | Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review Abstract Background Increased bioavailability of phenylephrine is reported when combined with paracetamol in over-the-counter formulations for the symptomatic treatment of the common cold and influen... |
PMC9268445 | core_pubmed_pmc | Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair ( Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS | Pharmacokinetics Study of Jin-Gu-Lian Prescription and Its Core Drug Pair ( Sargentodoxa cuneata (Oliv.) Rehd. et W and Alangium chinense (Lour.) Harms) by UPLC-MS/MS Abstract Jin-Gu-Lian (JGL) is traditionally used by Miao for the treatment of rheumatism arthralgia. At the same time, the combination of Sargentodoxa cu... |
PMC5591364 | core_pubmed_pmc | Mitomycin C hypoxic pelvic perfusion for unresectable recurrent rectal cancer: pharmacokinetic comparison of surgical and percutaneous techniques | Mitomycin C hypoxic pelvic perfusion for unresectable recurrent rectal cancer: pharmacokinetic comparison of surgical and percutaneous techniques Abstract Abstract Patients with unresectable recurrent rectal cancer that progresses after standard and multi-modular treatments are candidates for hypoxic pelvic perfusion. ... |
PMC6409996 | core_pubmed_pmc | Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation | Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation Abstract The aim of this study was to investigate the pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule... |
PMC11257179 | core_pubmed_pmc | Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model | Argon pharmacokinetics: measurements in pigs and analysis in humans using a physiologically based pharmacokinetics model Abstract Abstract The primary objective of this study was to investigate the pharmacokinetics of inhaled argon in young pigs using mechanical ventilation. Also a physiologically based model of argon ... |
PMC4224839 | core_pubmed_pmc | Evaluation of drug-drug interaction between daclatasvir and methadone or buprenorphine/naloxone | Evaluation of drug-drug interaction between daclatasvir and methadone or buprenorphine/naloxone Abstract Abstract Introduction Daclatasvir (DCV) is a potent hepatitis C virus (HCV) NS5A replication complex inhibitor with pangenotypic (1–6) activity in vitro. Methadone (MET) and buprenorphine (BUP) are opioid medication... |
PMC6105166 | core_pubmed_pmc | An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer | An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer Abstract Purpose Phase Ib study evaluating the effect of apalutamide, at therapeutic exposure, on ventricular repolarization by applying time-matched pharmaco... |
PMC6040239 | core_pubmed_pmc | Effect of lidocaine on kanamycin injection-site pain in patients with multidrug-resistant tuberculosis | Effect of lidocaine on kanamycin injection-site pain in patients with multidrug-resistant tuberculosis Abstract Abstract SETTING: Reducing pain from intramuscular injection of kanamycin (KM) could improve the tolerability of multidrug-resistant tuberculosis (MDR-TB) treatment. Lidocaine has been shown to be an effectiv... |
PMC7995584 | core_pubmed_pmc | Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology – what we know and what we do not know from randomized controlled trials | Biologic disease modifying antirheumatic drugs and Janus kinase inhibitors in paediatric rheumatology – what we know and what we do not know from randomized controlled trials Abstract Background Biologic disease modifying antirheumatic drugs (bDMARDs) and Janus Kinase (JAK) inhibitors are prescribed in adult and paedia... |
PMC5720630 | core_pubmed_pmc | Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy | Extending Metformin Use in Diabetic Kidney Disease: A Pharmacokinetic Study in Stage 4 Diabetic Nephropathy Abstract Abstract Introduction Metformin use in advanced chronic kidney disease is controversial. This study sought to examine the pharmacokinetics, safety, and efficacy of low-dose metformin in patients with typ... |
PMC7445428 | core_pubmed_pmc | Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial | Simplified dolutegravir dosing for children with HIV weighing 20 kg or more: pharmacokinetic and safety substudies of the multicentre, randomised ODYSSEY trial Abstract Summary Background Paediatric dolutegravir doses approved by stringent regulatory authorities (SRAs) for children weighing 20 kg to less than 40 kg unt... |
PMC8376136 | core_pubmed_pmc | A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation | A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation Abstract Abstract YH12852, a novel, highly selective 5‐hydroxytryptamine 4 (5‐HT 4 ) receptor agonist, is currently under development to... |
PMC10526061 | core_pubmed_pmc | A Systematic Review on the Clinical Pharmacokinetics of Cephalexin in Healthy and Diseased Populations | A Systematic Review on the Clinical Pharmacokinetics of Cephalexin in Healthy and Diseased Populations Abstract Abstract Cephalexin is a first-generation β-lactam antibiotic used in adults and pediatrics to treat various streptococcal and staphylococcal infections. This review aims to summarize and evaluate all the pha... |
PMC11257885 | core_pubmed_pmc | Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept | Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept Abstract Abstract Introduction Critically ill patients show large variability in drug disposition due to e.g., age, size, disease and treatment modalities. Physio... |
PMC10853450 | core_pubmed_pmc | Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs | Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs Abstract Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear. Alth... |
PMC7204663 | core_pubmed_pmc | Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin | Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin Abstract A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of... |
PMC5824342 | core_pubmed_pmc | Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN 7–14 and Antagonist RM26 | Positron Emission Tomography Imaging of Prostate Cancer with Ga-68-Labeled Gastrin-Releasing Peptide Receptor Agonist BBN 7–14 and Antagonist RM26 Abstract Abstract Radiolabeled bombesin (BBN) analogs have long been used for developing gastrin-releasing peptide receptor (GRPR) targeted imaging probes, and tracers with ... |
PMC5571318 | core_pubmed_pmc | Pharmacodynamics and Biodistribution of Single-Dose Liposomal Amphotericin B at Different Stages of Experimental Visceral Leishmaniasis | Pharmacodynamics and Biodistribution of Single-Dose Liposomal Amphotericin B at Different Stages of Experimental Visceral Leishmaniasis Abstract ABSTRACT Visceral leishmaniasis is a neglected tropical disease that causes significant morbidity and mortality worldwide. Characterization of the pharmacokinetics and pharmac... |
PMC7499079 | core_pubmed_pmc | Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats | Potential pharmacodynamic and pharmacokinetic interactions of Nigella Sativa and Trigonella Foenum-graecum with losartan in L-NAME induced hypertensive rats Abstract The objective of this investigation was to study whether Nigella Sativa and Trigonella Foenum-graecum , could modulate the losartan pharmacodynamic (PD) a... |
PMC10357575 | core_pubmed_pmc | Biopolymer-Capped Pyrazinamide-Loaded Colloidosomes: In Vitro Characterization and Bioavailability Studies | Biopolymer-Capped Pyrazinamide-Loaded Colloidosomes: In Vitro Characterization and Bioavailability Studies Abstract Abstract This study aimed to prepare colloidosome particles loaded with pyrazinamide (PZA). These drug-loaded colloidosomes were prepared using an in situ gelation technique using a central composite desi... |
PMC8509428 | core_pubmed_pmc | The Phenoxyalkyltriazine Antagonists for 5-HT 6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases | The Phenoxyalkyltriazine Antagonists for 5-HT 6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases Abstract Abstract Among the serotonin receptors, one of the most recently discovered 5-HT 6 subtype is an important protein target a... |
PMC8609688 | core_pubmed_pmc | Foslevodopa/Foscarbidopa Is Well Tolerated and Maintains Stable Levodopa and Carbidopa Exposure Following Subcutaneous Infusion | Foslevodopa/Foscarbidopa Is Well Tolerated and Maintains Stable Levodopa and Carbidopa Exposure Following Subcutaneous Infusion Abstract Background: Foslevodopa/foscarbidopa, formerly known as ABBV-951, is a formulation of levodopa/carbidopa prodrugs with solubility that allows for subcutaneous (SC) infusion and is in ... |
PMC12919684 | core_pubmed_pmc | Pharmacokinetics of Aztreonam–Avibactam After Single‐ and Multiple‐Dose Administration: A Phase 1, Open‐Label Study in Healthy Chinese Participants and Ethnic Comparison with Non‐Chinese Participants | Pharmacokinetics of Aztreonam–Avibactam After Single‐ and Multiple‐Dose Administration: A Phase 1, Open‐Label Study in Healthy Chinese Participants and Ethnic Comparison with Non‐Chinese Participants Abstract ABSTRACT Combined treatment with aztreonam (an established intravenous antibiotic) and avibactam (a β‐lactamase... |
PMC7188728 | core_pubmed_pmc | A phase I study investigation of metabolism, and disposition of [ 14 C]-anlotinib after an oral administration in patients with advanced refractory solid tumors | A phase I study investigation of metabolism, and disposition of [ 14 C]-anlotinib after an oral administration in patients with advanced refractory solid tumors Abstract Abstract Purpose Anlotinib is a novel oral multi-targeted receptor tyrosine kinase inhibitor, which selectively inhibits VEGFR2/3, FGFR1-4, PDGFR α/β,... |
PMC7269464 | core_pubmed_pmc | Pharmacokinetic-Pharmacodynamic Characterization of Omadacycline against Haemophilus influenzae Using a One-Compartment In Vitro Infection Model | Pharmacokinetic-Pharmacodynamic Characterization of Omadacycline against Haemophilus influenzae Using a One-Compartment In Vitro Infection Model Abstract Omadacycline is a novel aminomethylcycline with activity against Gram-positive and -negative organisms, including Haemophilus influenzae , which is one of the leading... |
PMC9245728 | core_pubmed_pmc | Dose Proportionality and Steady-State Pharmacokinetics of Serdexmethylphenidate/Dexmethylphenidate, a Novel Prodrug Combination to Treat Attention-Deficit/Hyperactivity Disorder | Dose Proportionality and Steady-State Pharmacokinetics of Serdexmethylphenidate/Dexmethylphenidate, a Novel Prodrug Combination to Treat Attention-Deficit/Hyperactivity Disorder Abstract Objective: The study was designed to determine (1) the pharmacokinetic (PK) profile of dexmethylphenidate (d-MPH) after oral administ... |
PMC7599917 | core_pubmed_pmc | Gellan Gum Promotes the Differentiation of Enterocytes from Human Induced Pluripotent Stem Cells | Gellan Gum Promotes the Differentiation of Enterocytes from Human Induced Pluripotent Stem Cells Abstract The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclin... |
PMC8227856 | core_pubmed_pmc | Antibacterial Activity of a Promising Antibacterial Agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin | Antibacterial Activity of a Promising Antibacterial Agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin Abstract Abstract A novel pleuromutilin derivative, 22-(4-(2-(4-nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin (NPDM), was synthesized in our labora... |
PMC6151824 | core_pubmed_pmc | Glycyrrhetinic Acid Liposomes Containing Mannose-Diester Lauric Diacid-Cholesterol Conjugate Synthesized by Lipase-Catalytic Acylation for Liver-Specific Delivery | Glycyrrhetinic Acid Liposomes Containing Mannose-Diester Lauric Diacid-Cholesterol Conjugate Synthesized by Lipase-Catalytic Acylation for Liver-Specific Delivery Abstract Abstract Mannose-diester lauric diacid-cholesterol (Man-DLD-Chol), as a liposomal target ligand, was synthesized by lipase catalyzed in a non-aqueou... |
PMC7032223 | core_pubmed_pmc | Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation | Development of a method to quantify total and free irinotecan and 7-ethyl-10-hydroxycamptothecin (SN-38) for pharmacokinetic and bio-distribution studies after administration of irinotecan liposomal formulation Abstract Abstract In 2015, liposomal formulation of irinotecan (ONIVYDE) has been approved by FDA and widely ... |
PMC11384982 | core_pubmed_pmc | Optimising infliximab induction dosing to achieve clinical remission in Chinese patients with Crohn’s disease | Optimising infliximab induction dosing to achieve clinical remission in Chinese patients with Crohn’s disease Abstract Aims A strategy based on therapeutic drug monitoring and population pharmacokinetic (popPK) models would likely increase the rate of clinical remission (CR) after infliximab (IFX) induction in patients... |
PMC12570999 | core_pubmed_pmc | Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats | Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats Abstract Abstract Purpose Lorlatinib, a third-generation inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1), undergoes extensive metabolism, with its disposition influenced by drug–drug interactions (DDIs). This stu... |
PMC3228569 | core_pubmed_pmc | Trichloroethylene and Cancer: Systematic and Quantitative Review of Epidemiologic Evidence for Identifying Hazards | Trichloroethylene and Cancer: Systematic and Quantitative Review of Epidemiologic Evidence for Identifying Hazards Abstract We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure ... |
PMC4341874 | core_pubmed_pmc | Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance? | Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance? Abstract Abstract Introduction The aim of this study was to explore the impact of augmented creatinine clearance and differing minimum inhibitory concentrations (MIC) on piperacillin pharmacokinetic/pharmacody... |
PMC12494133 | core_pubmed_pmc | Population pharmacokinetics of bictegravir in real-world people with HIV | Population pharmacokinetics of bictegravir in real-world people with HIV Abstract Abstract Objectives Bictegravir is an integrase strand transfer inhibitor widely prescribed due to its good efficacy and safety profile. Its pharmacokinetic (PK) profile has not been described in real-world settings yet. This study aimed ... |
PMC8481739 | core_pubmed_pmc | Comparative Bioavailability and Pharmacokinetics Between the Solid Form of Metformin vs a Novel Liquid Extemporaneous Formulation in Children | Comparative Bioavailability and Pharmacokinetics Between the Solid Form of Metformin vs a Novel Liquid Extemporaneous Formulation in Children Abstract Abstract Metformin pharmacokinetics in a liquid extemporaneous formulation from commercial tablets was determined in paediatric patients. A randomized, transversal clini... |
PMC6766590 | core_pubmed_pmc | Protocatechuic acid from chicory is bioavailable and undergoes partial glucuronidation and sulfation in healthy humans | Protocatechuic acid from chicory is bioavailable and undergoes partial glucuronidation and sulfation in healthy humans Abstract Abstract Protocatechuic acid exerts multiple health‐promoting effects such as anticancer, anti‐atherosclerosis, and neuroprotection in animal models. While protocatechuic acid produced in the ... |
PMC7316526 | core_pubmed_pmc | Operative Gynecological Laparoscopy Under Conscious Sedation | Operative Gynecological Laparoscopy Under Conscious Sedation Abstract Background and Objectives: Operative laparoscopy is generally performed under general anesthesia. Local anesthesia and conscious sedation may be useful in select short procedures. In the present study, we evaluated safety and efficacy of operative la... |
PMC3229549 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies | Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies Abstract Abstract Background Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-mediated signa... |
PMC12872619 | core_pubmed_pmc | Burixafor, a CXCR4 inhibitor with a differentiated kinetics profile: results of a phase 2 study for rapid cell mobilization in multiple myeloma and lymphoma patients undergoing transplant | Burixafor, a CXCR4 inhibitor with a differentiated kinetics profile: results of a phase 2 study for rapid cell mobilization in multiple myeloma and lymphoma patients undergoing transplant Abstract Abstract Inhibitors of C-X-C chemokine receptor type 4 (CXCR4) are standard of care for mobilization of hematopoietic stem ... |
PMC12355006 | core_pubmed_pmc | The Application of Mesoporous Silica Nanoparticles in Enhancing the Efficacy of Anti-Atherosclerosis Therapies: A Review | The Application of Mesoporous Silica Nanoparticles in Enhancing the Efficacy of Anti-Atherosclerosis Therapies: A Review Abstract Abstract Atherosclerosis (AS) is a chronic inflammatory condition of large arteries and a major contributor to cardiovascular disease (CVD) and stroke. The prevention of AS diseases involves... |
PMC8540141 | core_pubmed_pmc | Variants in COMT , CYP3A5 , CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics | Variants in COMT , CYP3A5 , CYP2B6, and ABCG2 Alter Quetiapine Pharmacokinetics Abstract Abstract Quetiapine is an atypical antipsychotic widely used for the treatment of schizophrenia and the depressive episodes of bipolar disorder. The aim of this work was to investigate the effect of variants in relevant pharmacogen... |
PMC5114206 | core_pubmed_pmc | An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs | An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs Abstract Abstract Given the distinctive characteristics of both epilepsy and antiepileptic drugs (AEDs), therapeutic drug monitoring (TDM) can make a significant contribution to the field of epilepsy. The measurement and interpretation of ... |
PMC5089583 | core_pubmed_pmc | Brentuximab vedotin, an antibody–drug conjugate, in patients with CD30‐positive haematologic malignancies and hepatic or renal impairment | Brentuximab vedotin, an antibody–drug conjugate, in patients with CD30‐positive haematologic malignancies and hepatic or renal impairment Abstract Abstract Aims Brentuximab vedotin, an antibody–drug conjugate (ADC), selectively delivers the microtubule‐disrupting agent monomethyl auristatin E (MMAE) into CD30‐expressin... |
PMC8512154 | core_pubmed_pmc | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management | Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management Abstract Abstract Gliomas are one of the prominent cancers of the central nervous system with limited therapeutic modalities. The present investigation evaluated the ... |
PMC10361232 | core_pubmed_pmc | Natural fulvic acids inhibit non-small-cell lung cancer through the COX-2/PGE2/EP4 axis: In silico and in vivo assessments | Natural fulvic acids inhibit non-small-cell lung cancer through the COX-2/PGE2/EP4 axis: In silico and in vivo assessments Abstract Abstract Purpose Non-small-cell lung cancer (NSCLC) is a major public health concern with a high incidence worldwide. Coal-derived fulvic acids (FAs) contain functional groups in their che... |
PMC12032439 | core_pubmed_pmc | Comparative Analysis of Adverse Event Profiles Among Seven Statins for Hypercholesterolemia Management Using the United States FDA Adverse Event Reporting System | Comparative Analysis of Adverse Event Profiles Among Seven Statins for Hypercholesterolemia Management Using the United States FDA Adverse Event Reporting System Abstract Abstract Background Statins are fundamental in hypercholesterolemia management, with seven primary drugs available: atorvastatin, simvastatin, rosuva... |
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