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PMC12781043 | core_pubmed_pmc | Antiurolithiatic Potential of a Series of Phthalimide Derivatives on Calcium Oxalate Crystals | Antiurolithiatic Potential of a Series of Phthalimide Derivatives on Calcium Oxalate Crystals Abstract ABSTRACT Urolithiasis, primarily caused by calcium oxalate crystals, represents a major health concern due to high recurrence rates and limitations of current treatments in dissolving existing stones. This study inves... |
PMC11310158 | core_pubmed_pmc | Transient efficacy of buparvaquone against the US isolate of Theileria orientalis Ikeda genotype in sub-clinically infected cattle | Transient efficacy of buparvaquone against the US isolate of Theileria orientalis Ikeda genotype in sub-clinically infected cattle Abstract Introduction Theileria orientalis , an economically significant tick-borne hemoparasite, infects cattle globally. The T. orientalis Ikeda genotype, transmitted by Haemaphysalis lon... |
PMC4434991 | core_pubmed_pmc | Single cell resolution in vivo imaging of DNA damage following PARP inhibition | Single cell resolution in vivo imaging of DNA damage following PARP inhibition Abstract Abstract Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo , typical response markers include late stage effects such as tumor shrinkage, progression free survival, or invasive repeat b... |
PMC11598970 | core_pubmed_pmc | Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model | Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model Abstract Prosthetic joint infections (PJIs) are a serious complication of orthopedic surgery. Bacteriophage (phage) therapy shows promise as an adjunctive treatment but requires further study,... |
PMC9628691 | core_pubmed_pmc | First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors | First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors Abstract Abstract Background OX40 is a costimulatory receptor upregulated on antigen-activated T cells and constitutively expressed on regulatory T cells (Tregs). INCAGN01949, a fully human immunoglob... |
PMC10762658 | core_pubmed_pmc | A Comprehensive Study on Nanoparticle Drug Delivery to the Brain: Application of Machine Learning Techniques | A Comprehensive Study on Nanoparticle Drug Delivery to the Brain: Application of Machine Learning Techniques Abstract The delivery of drugs to specific target tissues and cells in the brain poses a significant challenge in brain therapeutics, primarily due to limited understanding of how nanoparticle (NP) properties in... |
PMC4189711 | core_pubmed_pmc | Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers | Buccal acetaminophen provides fast analgesia: two randomized clinical trials in healthy volunteers Abstract Abstract Background Acetaminophen (APAP) by oral or intravenous (iv) routes is used for mild to moderate pain but may take time to be effective. When fast relief is required and/or oral or iv routes are not avail... |
PMC10489644 | core_pubmed_pmc | In Vitro Evaluation of the Potential for Drug Interactions by Salidroside | In Vitro Evaluation of the Potential for Drug Interactions by Salidroside Abstract Several studies utilizing Rhodiola rosea , which contains a complex mixture of phytochemicals, reported some positive drug-drug interaction (DDI) findings based on in vitro CYP450’s enzyme inhibition, MAO-A and MAO-B inhibition, and prec... |
PMC12144782 | core_pubmed_pmc | Exosomes in cancer nanomedicine: biotechnological advancements and innovations | Exosomes in cancer nanomedicine: biotechnological advancements and innovations Abstract Exosomes, as natural intercellular messengers, are gaining prominence as delivery vehicles in nanomedicine, offering a superior alternative to conventional synthetic nanoparticles for cancer therapeutics. Unlike lipid, polymer, or... |
PMC4272272 | core_pubmed_pmc | Effect of Hemodialysis on Plasma Glucose Profile and Plasma Level of Liraglutide in Patients with Type 2 Diabetes Mellitus and End-Stage Renal Disease: A Pilot Study | Effect of Hemodialysis on Plasma Glucose Profile and Plasma Level of Liraglutide in Patients with Type 2 Diabetes Mellitus and End-Stage Renal Disease: A Pilot Study Abstract Abstract The effect of hemodialysis on the plasma glucose profile and liraglutide level after liraglutide injection was investigated in patients ... |
PMC10132681 | core_pubmed_pmc | A comparative study of clinical effects and recovery characteristics of intraoperative dexmedetomidine infusion with ketamine versus fentanyl as adjuvants in general anaesthesia | A comparative study of clinical effects and recovery characteristics of intraoperative dexmedetomidine infusion with ketamine versus fentanyl as adjuvants in general anaesthesia Abstract ABSTRACT Background and Aims: Intraoperative dexmedetomidine infusion decreases the concurrent anaesthetic and analgesic requirement.... |
PMC6256767 | core_pubmed_pmc | Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment | Dried Blood Spot Technique-Based Liquid Chromatography-Tandem Mass Spectrometry Method as a Simple Alternative for Benznidazole Pharmacokinetic Assessment Abstract Chagas disease (CD) is recognized as one of the major neglected global tropical diseases. Benznidazole (BNZ) is the drug of choice for the treatment of adul... |
PMC10135420 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kg bw Following Intramuscular Administration | Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kg bw Following Intramuscular Administration Abstract A major problem of our time is the ever-increasing resistance to antimicrobial agents in bacterial populations. One of the most effective ways to prevent the... |
PMC12310320 | core_pubmed_pmc | Pharmacological Effects and Pharmacokinetic Profiles of Dehydroandrographolide | Pharmacological Effects and Pharmacokinetic Profiles of Dehydroandrographolide Abstract Dehydroandrographolide (Deh) is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata . In recent years, its pharmacological research has made remarkable progress in the fields of antibacteri... |
PMC9653451 | core_pubmed_pmc | Clinical-pharmacological drug information center of Hannover Medical School: experiences and analysis from a tertiary care university hospital | Clinical-pharmacological drug information center of Hannover Medical School: experiences and analysis from a tertiary care university hospital Abstract Drug information centers (DICs) are institutions dedicated to provide objective, independent, and up-to-date information on drugs and their rational use. To overcome th... |
PMC6704344 | core_pubmed_pmc | The Preclinical Pharmacological Study of a Novel Long-Acting Local Anesthetic, a Fixed-Dose Combination of QX-OH/Levobupivacaine, in Rats | The Preclinical Pharmacological Study of a Novel Long-Acting Local Anesthetic, a Fixed-Dose Combination of QX-OH/Levobupivacaine, in Rats Abstract Abstract Introduction: Previous studies demonstrated that 35 mM QX-OH/10 mM Levobupivacaine (LL-1), a fixed-dose combination, produced a long-acting effect in rat local anes... |
PMC12333187 | core_pubmed_pmc | Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions | Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions Abstract Abstract Metformin, a widely prescribed treatment for type 2 diabetes mellitus (T2DM), demonstrates significant inter-individual variability in its therapeutic response. This variabili... |
PMC12174063 | core_pubmed_pmc | Influence of awakening from general anesthesia on the distribution of glucose 2.5% with balanced electrolytes in adults | Influence of awakening from general anesthesia on the distribution of glucose 2.5% with balanced electrolytes in adults Abstract Abstract Background The glucose-free crystalloid fluid used for intravenous infusion during surgery might be combined with or replaced by 2.5% glucose in debilitated patients. The aim of the ... |
PMC11858071 | core_pubmed_pmc | Adaptive Resistance of Staphylococcus aureus to Cefquinome Sulfate in an In Vitro Pharmacokinetic Model with Transcriptomic Insights | Adaptive Resistance of Staphylococcus aureus to Cefquinome Sulfate in an In Vitro Pharmacokinetic Model with Transcriptomic Insights Abstract Cefquinome sulfate has a strong killing effect against Staphylococcus aureus ( S. aureus ), but bacterial resistance has become increasingly widespread. Experiments were conducte... |
PMC9016196 | core_pubmed_pmc | Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes | Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes Abstract Abstract Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzyme... |
PMC11868765 | core_pubmed_pmc | Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens | Model-guided development of pharmacokinetic/pharmacodynamic cut-offs and evaluation of sitafloxacin dosing regimens against target pathogens Abstract Introduction The establishment of clinical breakpoints for antimicrobial drug is crucial for guiding appropriate therapeutic interventions. This study aims to identify th... |
PMC3795472 | core_pubmed_pmc | Crystal Engineering of Green Tea Epigallocatechin-3-gallate (EGCg) Cocrystals and Pharmacokinetic Modulation in Rats | Crystal Engineering of Green Tea Epigallocatechin-3-gallate (EGCg) Cocrystals and Pharmacokinetic Modulation in Rats Abstract The most abundant polyphenol in green tea, epigallocatechin-3-gallate (EGCg), has recently received considerable attention due to the discovery of numerous health-promoting bioactivities. Despit... |
PMC3523201 | core_pubmed_pmc | PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse | PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse Abstract Background Advanced ovarian cancer is characterized by peritoneal metastasis and the accumulation of ascites. Peritoneal metastasis of ovarian cancer is a major cause of the negative treatment outcome, as... |
PMC7355663 | core_pubmed_pmc | Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs | Microscale Thermophoresis as a Screening Tool to Predict Melanin Binding of Drugs Abstract Abstract Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissu... |
PMC11652921 | core_pubmed_pmc | Phytoconstituents of Chloranthus elatior as a potential adjunct in the treatment of anxiety disorders: In vivo and in silico approaches | Phytoconstituents of Chloranthus elatior as a potential adjunct in the treatment of anxiety disorders: In vivo and in silico approaches Abstract Traditional plants have played a vital role in civilization and medicine throughout history. Chloranthus elatior , a plant used in South Asian traditional medicine, has variou... |
PMC3600730 | core_pubmed_pmc | A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development | A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development Abstract Abstract Assessing the safety of pharmacotherapies is a primary goal of clinical trials in drug development. The low frequency of relevant side effects, however, often poses a significant challenge for risk assessment. Methodologi... |
PMC12232875 | core_pubmed_pmc | Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy | Safety, Efficacy and Doxorubicin Pharmacokinetics During Cannabidiol/Cannabidiolic Acid Rich Hemp Oil Use in Dogs With Lymphoma Undergoing CHOP Chemotherapy Abstract ABSTRACT Background The safety of oral cannabidiol (CBD) and cannabidiolic acid (CBDA)‐rich hemp oil supplementation in dogs with cancer receiving chemoth... |
PMC8478074 | core_pubmed_pmc | In Silico Investigation of Phytoconstituents of Medicinal Herb ‘ Piper Longum ’ Against SARS-CoV-2 by Molecular Docking and Molecular Dynamics Analysis | In Silico Investigation of Phytoconstituents of Medicinal Herb ‘ Piper Longum ’ Against SARS-CoV-2 by Molecular Docking and Molecular Dynamics Analysis Abstract Unavailability of treatment for the SARS-CoV-2 virus has raised concern among the population worldwide. This has led to many attempts to find alternative optio... |
PMC9478751 | core_pubmed_pmc | Plasma atropine concentrations associated with decreased intestinal motility in horses | Plasma atropine concentrations associated with decreased intestinal motility in horses Abstract Abstract Introduction Atropine is an essential part of the treatment protocol for equine uveitis. Topical atropine administration has been associated with decreased intestinal motility and abdominal pain in horses. Experimen... |
PMC10525447 | core_pubmed_pmc | Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects | Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects Abstract This study aimed to explore the pharmacokinetics (PK) and safety of oral (PO) and intravenous (IV) lefamulin in healthy Chinese subjects and to evaluate the efficacy of the intravenous administr... |
PMC9341258 | core_pubmed_pmc | Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction | Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction Abstract Abstract Purpose This study aimed to characterize the pharmacokinetics of nalbuphine in patients undergoing general anesthesia with varying degrees of liver dysfunction. Patients and... |
PMC6670239 | core_pubmed_pmc | Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases: phase I dose escalation pharmacokinetic study | Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases: phase I dose escalation pharmacokinetic study Abstract Background Efficacy of treatments for colorectal liver metastases after failure of first-line chemotherapy is limited. The aim of this study was to prospectively e... |
PMC5238647 | core_pubmed_pmc | Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone | Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone Abstract Abstract In addition to its well-known abortifacient effect, mifepristone (MIF) has been used as an anticancer drug for various cancers in many studies with an in-depth understanding of the mechanism of action. Ho... |
PMC4403034 | core_pubmed_pmc | Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools | Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools Abstract Phenytoin (PHT) and Carbamazepine (CBZ) are excellent sodium channel blockers administered in clinical treatment of epileptic seizures. However, the narrow therapeutic range and limited ... |
PMC11954710 | core_pubmed_pmc | Influence of interleukin-6 on the pharmacokinetics and pharmacodynamics of osimertinib in patients with non-small cell lung cancer | Influence of interleukin-6 on the pharmacokinetics and pharmacodynamics of osimertinib in patients with non-small cell lung cancer Abstract Purpose The inflammatory cytokine interleukin (IL)-6 reduces the activity of drug metabolic enzymes and promotes tumor progression. We investigated the effect of IL-6 on the pharma... |
PMC10984927 | core_pubmed_pmc | Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model | Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model Abstract Abstract Background Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against carbapenemase-producing Enterobacteriaceae. The current EU... |
PMC12648730 | core_pubmed_pmc | Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment | Multi-targeted pharmacological actions and nanodelivery strategies of Garcinia cambogia: from molecular mechanisms to disease treatment Abstract Abstract Garcinia cambogia (Gambogic Acid, GA) is a natural xanthone compound extracted from the resin of GA fruit, renowned for its diverse biological activities and substant... |
PMC12310152 | core_pubmed_pmc | The Role of Sulopenem in the Treatment of Uncomplicated Urinary Tract Infections: A Systematic Review and Meta-Analysis | The Role of Sulopenem in the Treatment of Uncomplicated Urinary Tract Infections: A Systematic Review and Meta-Analysis Abstract Uncomplicated urinary tract infections (uUTIs) rank as one of the most frequent bacterial infections, particularly in females, and antimicrobial resistance is complicating the situation more ... |
PMC12959152 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application | Pharmacokinetic and pharmacodynamic modeling of anti-plasmodial drugs mefloquine plus artesunate: insights on translational application Abstract ABSTRACT A combination between artesunate (AS) and mefloquine (MQ) (ASMQ) is widely employed for the treatment of uncomplicated P. falciparum . Despite this, pharmacokinetic (... |
PMC7127093 | core_pubmed_pmc | Pharmacodynamics and Systems Pharmacology Approaches to Repurposing Drugs in the Wake of Global Health Burden | Pharmacodynamics and Systems Pharmacology Approaches to Repurposing Drugs in the Wake of Global Health Burden Abstract There are emergent needs for cost-effective treatment worldwide, for which repurposing to develop a drug with existing marketing approval of disease(s) for new disease(s) is a valid option. Although st... |
PMC8291577 | core_pubmed_pmc | The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital | The Potential Use of Ceftazidime-Avibactam Against Carbapenem Resistant Klebsiella pneumoniae Clinical Isolates Harboring Different Carbapenemase Types in a Thai University Hospital Abstract Abstract Purpose MBL and OXA-48 genes in carbapenem-resistant Enterobacterales (CRE) have emerged as a major public health proble... |
PMC8687330 | core_pubmed_pmc | Hypnosis regulation in propofol anaesthesia employing super‐twisting sliding mode control to compensate variability dynamics | Hypnosis regulation in propofol anaesthesia employing super‐twisting sliding mode control to compensate variability dynamics Abstract Abstract Regulation of hypnosis level on bi‐spectral index monitor (BIS) during a surgical procedure in propofol anaesthesia administration is a challenging task for an anaesthesiologist... |
PMC11614307 | core_pubmed_pmc | Artificial Intelligence-Driven Prediction Revealed CFTR Associated with Therapy Outcome of Breast Cancer: A Feasibility Study | Artificial Intelligence-Driven Prediction Revealed CFTR Associated with Therapy Outcome of Breast Cancer: A Feasibility Study Abstract Abstract Introduction In silico tools capable of predicting the functional consequences of genomic differences between individuals, many of which are AI-driven, have been the most effec... |
PMC11597518 | core_pubmed_pmc | Pharmacometabolomics Approach to Explore Pharmacokinetic Variation and Clinical Characteristics of a Single Dose of Desvenlafaxine in Healthy Volunteers | Pharmacometabolomics Approach to Explore Pharmacokinetic Variation and Clinical Characteristics of a Single Dose of Desvenlafaxine in Healthy Volunteers Abstract Abstract This study investigated the effects of a single dose of desvenlafaxine via oral administration on the pharmacokinetic parameters and clinical and lab... |
PMC7996508 | core_pubmed_pmc | Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications | Overview of Synthetic Cannabinoids ADB-FUBINACA and AMB-FUBINACA: Clinical, Analytical, and Forensic Implications Abstract ADB-FUBINACA and AMB-FUBINACA are two synthetic indazole-derived cannabinoid receptor agonists, up to 140- and 85-fold more potent, respectively, than trans -∆ 9 -tetrahydrocannabinol (∆ 9 -THC), t... |
PMC7193447 | core_pubmed_pmc | The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations | The influence of genetic polymorphisms in drug metabolism enzymes and transporters on the pharmacokinetics of different fluvastatin formulations Abstract The purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the fluvastatin pharm... |
PMC12124994 | core_pubmed_pmc | Assessments of CYP‐Inhibition‐Based Drug–Drug Interactions Between Tofacitinib and Lipid‐Lowering Agents in Rats Both In Vitro and In Vivo | Assessments of CYP‐Inhibition‐Based Drug–Drug Interactions Between Tofacitinib and Lipid‐Lowering Agents in Rats Both In Vitro and In Vivo Abstract ABSTRACT Tofacitinib is a widely used medication for the treatment of arthritis. It has been reported that some patients experience abnormal cholesterol levels following tr... |
PMC10733198 | core_pubmed_pmc | Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice | Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice Abstract Abstract Introduction The unbound brain extracelullar fluid (brain ECF ) to plasma steady state partition coefficient, K p,uu,BBB , values provide steady-state information on the ext... |
PMC11344734 | core_pubmed_pmc | Apixaban Use in Patients with Kidney Impairment: A Review of Pharmacokinetic, Interventional, and Observational Study Data | Apixaban Use in Patients with Kidney Impairment: A Review of Pharmacokinetic, Interventional, and Observational Study Data Abstract Chronic kidney disease (CKD) remains a significant global health issue and is a leading cause of mortality worldwide. Patients with CKD have an increased risk of developing atrial fibrilla... |
PMC5762439 | core_pubmed_pmc | Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma ☆ | Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma ☆ Abstract Abstract TM-2 known as a potential antitumor drug is a novel semi-synthetic taxane derivative. As drug–protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties, w... |
PMC8923478 | core_pubmed_pmc | Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery | Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery Abstract This preliminary clinical investigation of the pharmacokinetic behavior of the main metamizole (dipyrone) metabolites 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine (4-AA) in calves undergoing umbilical surgery... |
PMC3503738 | core_pubmed_pmc | Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia | Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia Abstract Abstract Background Dehorning is a common practice involving calves on dairy operations in the United States. However, less than 20% of producers report using analgesics or anesthet... |
PMC8983296 | core_pubmed_pmc | Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin | Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin Abstract Abstract This study analyzed the pharmacokinetics of orbifloxacin (OBFX) in plasma, and its migration and retention in epithelial lining fluid (ELF) and alveolar cells within the broncho... |
PMC12771704 | core_pubmed_pmc | Integrating serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of KaiXinSan in treating insomnia | Integrating serum pharmacochemistry with network pharmacology and pharmacological validation to elucidate the mechanism of KaiXinSan in treating insomnia Abstract Abstract Background KaiXinSan (KXS) is a classic Chinese herbal compound used for treating insomnia and related mental disorders. Modern medical studies have... |
PMC4579261 | core_pubmed_pmc | Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration | Pharmacokinetics and Bioavailability of a Fixed-Dose Combination of Ibuprofen and Paracetamol after Intravenous and Oral Administration Abstract Background and Objectives Previously published studies have suggested the lack of a pharmacokinetic interaction between ibuprofen and paracetamol when they are delivered as a ... |
PMC7166056 | core_pubmed_pmc | The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling | The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling Abstract Abstract Background and Objectives Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials o... |
PMC9843845 | core_pubmed_pmc | Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil | Pharmacodynamic modeling of moderate sedation and rationale for dosing using midazolam, propofol and alfentanil Abstract Abstract Purpose Regulations have broadened to allow moderate sedation administration for gastrointestinal endoscopy by non-anesthesia personnel. The line between moderate and deep sedation is ambigu... |
PMC3457953 | core_pubmed_pmc | Population PK/PD Model of Homocysteine Concentrations after High-Dose Methotrexate Treatment in Patients with Acute Lymphoblastic Leukemia | Population PK/PD Model of Homocysteine Concentrations after High-Dose Methotrexate Treatment in Patients with Acute Lymphoblastic Leukemia Abstract Elevated homocysteine concentrations have been associated with methotrexate-induced neurotoxicity. Based on methotrexate and homocysteine plasma concentrations of 494 child... |
PMC9032884 | core_pubmed_pmc | Pharmacokinetic Variability Drives Palbociclib-Induced Neutropenia in Metastatic Breast Cancer Patients: Drug–Drug Interactions Are the Usual Suspects | Pharmacokinetic Variability Drives Palbociclib-Induced Neutropenia in Metastatic Breast Cancer Patients: Drug–Drug Interactions Are the Usual Suspects Abstract Abstract Palbociclib is a good candidate for therapeutic drug monitoring (TDM) due to its narrow therapeutic range and frequency of toxicities, particularly hig... |
PMC12707346 | core_pubmed_pmc | Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency | Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency Abstract Abstract Triosephosphate Isomerase deficiency (TPI-Df) is a devastating untreatable childhood metabolic disease resulting in anemia, severe locomotor impairment, and... |
PMC9695805 | core_pubmed_pmc | Statins as Repurposed Drugs in Gynecological Cancer: A Review | Statins as Repurposed Drugs in Gynecological Cancer: A Review Abstract Discovering new drugs is an expensive and time-consuming process, including target identification, bioavailability, pharmacokinetic (PK) tests, pharmacodynamic (PD) tests, toxicity profiles, recommended dosage test, and observation of the side effec... |
PMC8399437 | core_pubmed_pmc | Model-Informed Repurposing of Medicines for SARS-CoV-2: Extrapolation of Antiviral Activity and Dose Rationale for Paediatric Patients | Model-Informed Repurposing of Medicines for SARS-CoV-2: Extrapolation of Antiviral Activity and Dose Rationale for Paediatric Patients Abstract Abstract Repurposing of remdesivir and other drugs with potential antiviral activity has been the basis of numerous clinical trials aimed at SARS-CoV-2 infection in adults. How... |
PMC9124818 | core_pubmed_pmc | In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions | In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions Abstract Abstract Studies support the safety and efficacy of fenfluramine (FFA) as an antiseizure medication (ASM) in Dravet syndrome, Lennox‐Gastaut syndrome, or CDKL5 deficiency disorder, all pharmac... |
PMC8954547 | core_pubmed_pmc | Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK 2 R Cancer Theranostic Agents: A Preclinical Study | Nonpeptidic Z360-Analogs Tagged with Trivalent Radiometals as Anti-CCK 2 R Cancer Theranostic Agents: A Preclinical Study Abstract Abstract (1) Background: Theranostic approaches in the management of cholecystokinin subtype 2 receptor (CCK 2 R)-positive tumors include radiolabeled gastrin and CCK motifs. Moving toward ... |
PMC11394034 | core_pubmed_pmc | Transdermal Fentanyl in Patients with Cachexia—A Scoping Review | Transdermal Fentanyl in Patients with Cachexia—A Scoping Review Abstract Abstract Simple Summary This scoping review explores the use of transdermal fentanyl (TDF) for pain management in patients with cachexia, which is a severe wasting syndrome associated with cancer and other advanced illnesses. While TDF is commonly... |
PMC9526508 | core_pubmed_pmc | Development and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery | Development and Evaluation of Puerarin Loaded-Albumin Nanoparticles Thermoresponsive in situ Gel for Ophthalmic Delivery Abstract Purpose Puerarin (PUR) is a major bioactive ingredient extracted from the root of Pueraria lobata (Willd.) Ohwi, which is known as Gegen in traditional Chinese medicine. Conventional PUR oph... |
PMC9817697 | core_pubmed_pmc | Repurposing Drugs in Small Animal Oncology | Repurposing Drugs in Small Animal Oncology Abstract Simple Summary Repurposing drugs in oncology consists of using off-label drugs that are licensed for various non-oncological medical conditions to treat cancer. Repurposing drugs has the advantage of using drugs that are already commercialized, with known mechanisms o... |
PMC7188725 | core_pubmed_pmc | Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors | Intravenous 5-fluoro-2′-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors Abstract Abstract Purpose Following promising responses to the DNA methyltransferase (DNMT) inhibitor 5-fluoro-2′-deoxycytidine (FdCyd) comb... |
PMC8130796 | core_pubmed_pmc | Intratumoural administration and tumour tissue targeting of cancer immunotherapies | Intratumoural administration and tumour tissue targeting of cancer immunotherapies Abstract Abstract Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are revolutionizing oncology and haematology practice. With these and other immunotherapies, however, systemic biodistribution raises safety issue... |
PMC9148593 | core_pubmed_pmc | Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp) | Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp) Abstract Treatment of SARS-CoV-2 targeting its RNA dependent RNA polymerase (RdRp) is of current interest. Remdesivir has been approved for the treatment of COVID-19 around the world.... |
PMC3446861 | core_pubmed_pmc | A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1 | A silica-based pH-sensitive nanomatrix system improves the oral absorption and efficacy of incretin hormone glucagon-like peptide-1 Abstract Abstract Background Glucagon-like peptide-1 (GLP-1) (7–36) is a peptide incretin hormone released from the endocrine L-cells of the intestinal mucosa with unique antidiabetic pote... |
PMC6972599 | core_pubmed_pmc | Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma | Subcutaneous mepolizumab in children aged 6 to 11 years with severe eosinophilic asthma Abstract Abstract Objectives There are no published reports for anti‐interleukin‐5 therapy in children <12 years with asthma. The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics of mepol... |
PMC11337926 | core_pubmed_pmc | Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT | Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT Abstract Abstract Boron neutron capture therapy (BNCT) is a cancer treatment modality b... |
PMC11858910 | core_pubmed_pmc | Quantifying Heart Rate Changes After Delta-9-Tetrahydrocannabinol Administration Using a PBPK-PD Model in Healthy Adults | Quantifying Heart Rate Changes After Delta-9-Tetrahydrocannabinol Administration Using a PBPK-PD Model in Healthy Adults Abstract Background : As cannabis becomes legal in several U.S. states, the risk of THC-induced tachycardia increases. This study aimed to develop and verify a physiologically based pharmacokinetic–p... |
PMC12358753 | core_pubmed_pmc | Long-acting relaxin analogues: a novel tool in cardiology | Long-acting relaxin analogues: a novel tool in cardiology Abstract Serelaxin, a recombinant human relaxin, has emerged as a potential therapy for the future treatment of heart failure. However, its effectiveness has been limited by a short half-life and the need for intravenous administration. Recently developed long-a... |
PMC7306618 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions | Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions Abstract Abstract Fenebrutinib is a CYP3A substrate and time‐dependent inhibitor, as well as a BCRP and OATP1B transporter inhibitor in vitro . Physiologically‐based pharmacokinetic (PBPK... |
PMC11201170 | core_pubmed_pmc | Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review | Antibiotic–Drug Interactions in the Intensive Care Unit: A Literature Review Abstract Abstract Interactions between drugs are a common problem in Intensive Care Unit patients, as they mainly have a critical condition that often demands the administration of multiple drugs simultaneously. Antibiotics are among the most ... |
PMC11547497 | core_pubmed_pmc | Construction and Evaluation of Hepatic Targeted Drug Delivery System with Hydroxycamptothecin in Stem Cell-Derived Exosomes | Construction and Evaluation of Hepatic Targeted Drug Delivery System with Hydroxycamptothecin in Stem Cell-Derived Exosomes Abstract Hydroxycamptothecin (HCPT) is commonly used in the treatment of liver cancer; however, its low water solubility and poor stability significantly limit its clinical application. In recent ... |
PMC10440361 | core_pubmed_pmc | OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis | OCE-205 in rats and non-human primates: Pharmacokinetic and pharmacodynamic analysis Abstract Treatment for complications associated with the hemodynamic consequences of decompensated cirrhosis remains suboptimal. Terlipressin, the latest pharmacological management of hepatorenal syndrome–acute kidney injury (HRS-AKI),... |
PMC12802920 | core_pubmed_pmc | Preventing resistance development in infections by OXA β-lactamase-producing Pseudomonas aeruginosa : correlating clinical outcomes with hollow-fibre model input | Preventing resistance development in infections by OXA β-lactamase-producing Pseudomonas aeruginosa : correlating clinical outcomes with hollow-fibre model input Abstract Abstract Background Infections caused by XDR Pseudomonas aeruginosa significantly limit treatment options. Although ceftolozane/tazobactam and ceftaz... |
PMC12193238 | core_pubmed_pmc | Repurposing Biomolecules from Aerva javanica Against DDX3X in LAML: A Computer-Aided Therapeutic Approach | Repurposing Biomolecules from Aerva javanica Against DDX3X in LAML: A Computer-Aided Therapeutic Approach Abstract Abstract Acute Myeloid Leukemia (LAML) is a life-threatening hematological malignancy, and the DEAD-box helicase 3 X-linked ( DDX3X ) gene is a potential yet underexplored target gene for LAML. Biomolecule... |
PMC11064166 | core_pubmed_pmc | An Isolated Perfused Rat Liver Model: Simultaneous LC-MS Quantification of Pitavastatin, Coproporphyrin I, and Coproporphyrin III Levels in the Rat Liver and Bile | An Isolated Perfused Rat Liver Model: Simultaneous LC-MS Quantification of Pitavastatin, Coproporphyrin I, and Coproporphyrin III Levels in the Rat Liver and Bile Abstract The isolated perfused rat liver (IPRL) model provides a mechanistic understanding of the organic-anion-transporting polypeptide (OATP/Oatp)-mediated... |
PMC7467963 | core_pubmed_pmc | Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies | Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies Abstract Abstract Background Nicotine, the pharmacologically active substance in both tobacco and many electronic cigarette (e-cigarette) liquids, is responsible for the addiction that sustains cigarette smoking. With... |
PMC9493122 | core_pubmed_pmc | PK/PD integration of florfenicol alone and in combination with doxycycline against Riemerella anatipestifer | PK/PD integration of florfenicol alone and in combination with doxycycline against Riemerella anatipestifer Abstract Riemerella anatipestifer (RA) is an important pathogen found in poultry. RA infection can kill ducks and lead to significant economic losses. Seven RA strains with different susceptibility phenotypes wer... |
PMC11450137 | core_pubmed_pmc | Extrapolation of the Efficacy and Pharmacokinetics of Belimumab to Support its Use in Children with Lupus Nephritis | Extrapolation of the Efficacy and Pharmacokinetics of Belimumab to Support its Use in Children with Lupus Nephritis Abstract Background and Objective Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, has greater severity in children versus adults. Belimumab is approved for systemic lupus ery... |
PMC3804792 | core_pubmed_pmc | Dose Adjustment Strategy of Cyclosporine A in Renal Transplant Patients: Evaluation of Anthropometric Parameters for Dose Adjustment and C0 vs. C2 Monitoring in Japan, 2001-2010 | Dose Adjustment Strategy of Cyclosporine A in Renal Transplant Patients: Evaluation of Anthropometric Parameters for Dose Adjustment and C0 vs. C2 Monitoring in Japan, 2001-2010 Abstract The optimal use and monitoring of cyclosporine A (CyA) have remained unclear and the current strategy of CyA treatment requires frequ... |
PMC10469688 | core_pubmed_pmc | Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants | Comparative pharmacokinetics and safety evaluation of high dosage regimens of Andrographis paniculata aqueous extract after single and multiple oral administration in healthy participants Abstract Background: The prolonged situation of the COVID-19 pandemic, with the emergence of new variants of SARS-CoV-2, not only im... |
PMC6154009 | core_pubmed_pmc | Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies | Quantification of a Novel Photosensitizer of Chlorin e6-C15-Monomethyl Ester in Beagle Dog Plasma Using HPLC: Application to Pharmacokinetic Studies Abstract Chlorin e6-C15-monomethyl ester (CMME) is a novel photosensitizer, which is synthetized from the degradation products of silkworm excrement. Preclinical studies o... |
PMC8929124 | core_pubmed_pmc | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments Abstract Abstract The use of pharmaceuticals to treat Major Depressive Disorder (MDD) has several drawbacks, including severe side effects. Natural compounds with great efficacy and few side effects are in hig... |
PMC4286001 | core_pubmed_pmc | Effects of food on the pharmacokinetics of ponatinib in healthy subjects | Effects of food on the pharmacokinetics of ponatinib in healthy subjects Abstract What is known and objective Ponatinib is a potent oral tyrosine kinase inhibitor with activity against BCR-ABL, the primary driver of chronic myeloid leukaemia and Philadelphia chromosome–positive acute lymphoblastic leukaemia. This singl... |
PMC7344756 | core_pubmed_pmc | Molecular Interaction Characterization Strategies for the Development of New Biotherapeutic Antibody Modalities | Molecular Interaction Characterization Strategies for the Development of New Biotherapeutic Antibody Modalities Abstract The characterization of target binding interactions is critical at each stage of antibody therapeutic development. During early development, it is important to design fit-for-purpose in vitro molecul... |
PMC12477151 | core_pubmed_pmc | STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases | STING-targeting PROTACs: emerging therapeutic tools for enhanced immunotherapy in inflammatory diseases Abstract The stimulator of interferon genes (STING) pathway is a central regulator of innate immunity, mediating host defense against pathogens but driving chronic inflammation when dysregulated-underpinning autoimmu... |
PMC4999860 | core_pubmed_pmc | A Single Dose of Viperfav TM May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation | A Single Dose of Viperfav TM May Be Inadequate for Vipera ammodytes Snake Bite: A Case Report and Pharmacokinetic Evaluation Abstract Abstract Viperfav TM is a commercial F(ab’) 2 antivenom prepared against European vipers venom. It is safe and effective for treating envenomation caused by Vipera aspis and Vipera berus... |
PMC9694679 | core_pubmed_pmc | CYP2C9 Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid | CYP2C9 Polymorphism Influence in PK/PD Model of Naproxen and 6-O-Desmethylnaproxen in Oral Fluid Abstract Polymorphisms in CYP2C9 can significantly interfere with the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen. The present research aimed... |
PMC8533588 | core_pubmed_pmc | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris | The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris Abstract Artemisia capillaris Thunb. ( A. capillaris , Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of seve... |
PMC7934181 | core_pubmed_pmc | Compared efficacy and tolerance of the neuromuscular blockade induced by brand-name (Nimbex®) and generic (Cisatrex®) of cisatracurium in mechanically ventilated critically ill patients: a crossover double-blind randomized study | Compared efficacy and tolerance of the neuromuscular blockade induced by brand-name (Nimbex®) and generic (Cisatrex®) of cisatracurium in mechanically ventilated critically ill patients: a crossover double-blind randomized study Abstract Abstract Introduction use of generic drugs is common. However, there is still conc... |
PMC9291756 | core_pubmed_pmc | Pharmacokinetics of enflicoxib in dogs: Effects of prandial state and repeated administration | Pharmacokinetics of enflicoxib in dogs: Effects of prandial state and repeated administration Abstract Abstract The pharmacokinetics of enflicoxib were evaluated in both a bioavailability study and a multi‐dose safety study in Beagle dogs. When administered at 8 mg/kg, the oral bioavailability (F) of enflicoxib was 44.... |
PMC7825194 | core_pubmed_pmc | Combining Model‐Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design | Combining Model‐Based Clinical Trial Simulation, Pharmacoeconomics, and Value of Information to Optimize Trial Design Abstract Abstract The Bayesian decision‐analytic approach to trial design uses prior distributions for treatment effects, updated with likelihoods for proposed trial data. Prior distributions for treatm... |
PMC11351987 | core_pubmed_pmc | Upholding or Breaking the Law of Superposition in Pharmacokinetics | Upholding or Breaking the Law of Superposition in Pharmacokinetics Abstract Abstract The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose re... |
PMC6414755 | core_pubmed_pmc | Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES | Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES Abstract Abstract Antiretroviral-releasing vaginal rings are at the forefront of ongoing efforts to develop microbicide-based strategies for prevention of heterosexual transmission of the human immunodeficiency virus (HIV). Ho... |
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