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PMC10777848 | core_pubmed_pmc | In vivo dose response and efficacy of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against the Acinetobacter baumannii-calcoaceticus complex | In vivo dose response and efficacy of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against the Acinetobacter baumannii-calcoaceticus complex Abstract ABSTRACT Multi-drug resistant (MDR) Acinetobacter baumannii is emerging as a pathogen of increasing prevalence and concern. Infections associated... |
PMC8527364 | core_pubmed_pmc | Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis | Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis Abstract Background and Objectives Costimulation by CD40 and its ligand CD40L (CD154) is important for the functional differentiation of T cells. Preclinical studies have recognized the importance of this costimulatory interaction in the pathogenes... |
PMC11011675 | core_pubmed_pmc | Applications of Flow Cytometry in Drug Discovery and Translational Research | Applications of Flow Cytometry in Drug Discovery and Translational Research Abstract Abstract Flow cytometry is a mainstay technique in cell biology research, where it is used for phenotypic analysis of mixed cell populations. Quantitative approaches have unlocked a deeper value of flow cytometry in drug discovery rese... |
PMC7098057 | core_pubmed_pmc | Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach | Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach Abstract Numerous studies have engineered nanoparticles with different physicochemical properties to enhance the delivery efficiency to solid tumors, yet the mean and median delivery efficienc... |
PMC3543712 | core_pubmed_pmc | ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO | ASAP ECMO: Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO Abstract Background Given the expanding scope of extracorporeal membrane oxygenation (ECMO) and its variable impact on drug pharmacokinetics as observed in... |
PMC12033152 | core_pubmed_pmc | CT-P17 Adalimumab Biosimilar in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: An Open-Label Extension of a Phase 3 Interchangeability Study | CT-P17 Adalimumab Biosimilar in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: An Open-Label Extension of a Phase 3 Interchangeability Study Abstract Introduction A 27-week analysis of this phase 3 study demonstrated the interchangeability of the adalimumab biosimilar CT-P17 and reference adalimumab. The cu... |
PMC4689264 | core_pubmed_pmc | Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration | Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration Abstract Choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) is an important cause of visual morbidity globally. Modern treatment strategies for neovascular AMD achieve ... |
PMC10962475 | core_pubmed_pmc | Baricitinib and tofacitinib off‐target profile, with a focus on Alzheimer's disease | Baricitinib and tofacitinib off‐target profile, with a focus on Alzheimer's disease Abstract Abstract INTRODUCTION Janus kinase (JAK) inhibitors were recently identified as promising drug candidates for repurposing in Alzheimer's disease (AD) due to their capacity to suppress inflammation via modulation of JAK/STAT sig... |
PMC5225340 | core_pubmed_pmc | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology | Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology Abstract Abstract Diosgenin, a steroidal sapogenin, occurs abundantly in plants such as Dioscorea alata , Smilax China, and Trigonella foenum graecum . This bioactive phytochemical not only is used as an important starting material for the preparat... |
PMC10873233 | core_pubmed_pmc | Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals | Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals Abstract Purpose The aim of this study was to examine the age of onset for increased dose-adjusted serum concentrations (C/D ratio) of common antidepressan... |
PMC9137603 | core_pubmed_pmc | Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice | Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice Abstract Abstract Given the increase in bacterial resistance and the decrease in the development of new antibiotics, the appropriate use of old antimicrobials has become even more compulsory. Clindamycin is a lincosamide an... |
PMC10097735 | core_pubmed_pmc | Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates | Predictive Performance of Population Pharmacokinetic Models for Amikacin in Term Neonates Abstract Background and Objective Amikacin is preferred in treating Gram-negative infections in neonates and it has a narrow therapeutic window. The population pharmacokinetic modeling approach can aid in designing optimal dosage ... |
PMC11509005 | core_pubmed_pmc | Synthesis, Cytotoxicity, and Mechanistic Evaluation of Tetrahydrocurcumin-Amino Acid Conjugates as LAT1-Targeting Anticancer Agents in C6 Glioma Cells | Synthesis, Cytotoxicity, and Mechanistic Evaluation of Tetrahydrocurcumin-Amino Acid Conjugates as LAT1-Targeting Anticancer Agents in C6 Glioma Cells Abstract Abstract Glioblastoma, a fatal brain cancer with limited treatments and poor prognosis, could benefit from targeting the L-type amino acid transporter I (LAT1).... |
PMC9462537 | core_pubmed_pmc | Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib | Application of physiologically-based pharmacokinetic/pharmacodynamic models to evaluate the interaction between nifedipine and apatinib Abstract Abstract Aim: It has been found that the co-administration of nifedipine with apatinib could cause exposure changes of nifedipine in vivo . But, whether this pharmacokinetic d... |
PMC7589709 | core_pubmed_pmc | Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer | Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer Abstract Abstract Bromo and extraterminal domain (BET) inhibitors-PROteolysis TArgeting Chimera (BETi-PROTAC) is a new family of compounds that induce proteasomal degradation through the ub... |
PMC3943008 | core_pubmed_pmc | Pharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass Spectrometry | Pharmacokinetic Studies of Chinese Medicinal Herbs Using an Automated Blood Sampling System and Liquid Chromatography-mass Spectrometry Abstract Abstract The safety of herbal products is one of the major concerns for the modernization of traditional Chinese medicine, and pharmacokinetic data of medicinal herbs guide us... |
PMC8024557 | core_pubmed_pmc | Spontaneous Reports of Serious Adverse Drug Reactions Resulting From Drug–Drug Interactions: An Analysis From the French Pharmacovigilance Database | Spontaneous Reports of Serious Adverse Drug Reactions Resulting From Drug–Drug Interactions: An Analysis From the French Pharmacovigilance Database Abstract Abstract Few data are available on the clinical impact of drug–drug interactions (DDIs). Most of the studies are limited to the analysis of exposure to potential D... |
PMC12433005 | core_pubmed_pmc | Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids | Multi-drug pharmacotyping improves therapy prediction in pancreatic cancer organoids Abstract Patient-Derived Organoids (PDOs) represent a promising technology for therapy prediction in pancreatic cancer, with the potential of enhancing treatment outcomes and allowing more effective, personalized treatment choices. How... |
PMC12735420 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Evaluation of PZ-2891, an Anti-Alzheimer’s Disease Agonist of PANK2 | Pharmacokinetic and Pharmacodynamic Evaluation of PZ-2891, an Anti-Alzheimer’s Disease Agonist of PANK2 Abstract Abstract Background/Objectives: Alzheimer’s disease (AD) is a neurodegenerative disorder with a high incidence but limited agents. Herein, PZ-2891 was discovered as a novel anti-AD candidate. Both in vivo an... |
PMC11015209 | core_pubmed_pmc | Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics | Autologous human preclinical modeling of melanoma interpatient clinical responses to immunotherapeutics Abstract Background Despite recent advances in immunotherapy, a substantial population of late-stage melanoma patients still fail to achieve sustained clinical benefit. Lack of translational preclinical models contin... |
PMC9604366 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools | Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution: A Review of Existing Models, Simulation Software, and Data Analysis Tools Abstract Cancer treatment and pharmaceutical development require targeted treatment and less toxic therapeutic intervention to achieve real progress against this dise... |
PMC5024330 | core_pubmed_pmc | Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5 | Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5 Abstract Recent reviews suggest that chronic kidney disease (CKD) can affect the pharmacokinetics of nonrenally eliminated drugs, but the impact of CKD on individual elimination pathways has not been systematically eva... |
PMC467072 | core_pubmed_pmc | Optimal use of β-lactams in neonates: machine learning-based clinical decision support system | Optimal use of β-lactams in neonates: machine learning-based clinical decision support system Abstract Summary Background Accurate prediction of the optimal dose for β-lactam antibiotics in neonatal sepsis is challenging. We aimed to evaluate whether a reliable clinical decision support system (CDSS) based on machine l... |
PMC10992703 | core_pubmed_pmc | Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system | Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system Abstract RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relations... |
PMC5496406 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers | Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers Abstract Background Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma conce... |
PMC9610285 | core_pubmed_pmc | Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline | Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline Abstract Abstract Rasagiline is a selective and irreversible inhibitor of monoamine oxidase type B with neuroprotective effect, indicated for the management of Parkinson’s disease. The aim of this work was... |
PMC7381488 | core_pubmed_pmc | Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques | Single oral dose for HIV pre or post-exposure prophylaxis: user desirability and biological efficacy in macaques Abstract Background Daily oral pre- or post-exposure prophylaxis (PrEP or PEP) is highly effective in preventing HIV infection. However, many people find it challenging to adhere to a daily oral regimen. Che... |
PMC9992171 | core_pubmed_pmc | Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon ® ) | Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (Dimebon ® ) Abstract Introduction: Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (Dimebon ® ) in relationship with its polymorphic forms have been ... |
PMC8085489 | core_pubmed_pmc | Comparison of Rifamycins for Efficacy Against Mycobacterium avium Complex and Resistance Emergence in the Hollow Fiber Model System | Comparison of Rifamycins for Efficacy Against Mycobacterium avium Complex and Resistance Emergence in the Hollow Fiber Model System Abstract Abstract Rifamycins are integral part of the combination regimen for treatment of pulmonary Mycobacterium avium-complex [MAC] infection, but different practitioners prefer differe... |
PMC7658164 | core_pubmed_pmc | A higher dose of vancomycin is needed in critically ill patients with augmented renal clearance | A higher dose of vancomycin is needed in critically ill patients with augmented renal clearance Abstract Abstract Background Using standard vancomycin dosage in critically ill patients might lead to therapy failure and worse patient outcomes, augmented renal clearance (ARC) may be the leading risk factor. In this study... |
PMC6407593 | core_pubmed_pmc | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles | Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles Abstract Abstract The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET... |
PMC8932720 | core_pubmed_pmc | Rituximab exposure‐response in triweekly R‐CHOP treatment in DLBCL: A loading dose is recommended to improve clinical outcomes | Rituximab exposure‐response in triweekly R‐CHOP treatment in DLBCL: A loading dose is recommended to improve clinical outcomes Abstract Abstract Previous exposure‐response analyses for rituximab suggest that higher rituximab concentrations were associated with an improvement in efficacy, however, clinical studies inves... |
PMC8868236 | core_pubmed_pmc | PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets | PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets Abstract Streptococcus suis ( S. suis ) causes severe respiratory diseases in pigs and is also an important pathogen causing hidden dangers to public health and safety. Acetylkitasamycin is a new macrolide agent that ha... |
PMC5315214 | core_pubmed_pmc | Pharmacokinetics of conivaptan use in patients with severe hepatic impairment | Pharmacokinetics of conivaptan use in patients with severe hepatic impairment Abstract Abstract Purpose Conivaptan is an intravenous dual V 1A /V 2 vasopressin antagonist approved for the treatment of euvolemic and hypervolemic hyponatremia. Earlier studies showed that patients with moderate liver disease could be safe... |
PMC11649407 | core_pubmed_pmc | Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites | Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites Abstract Background Gliclazide, a second-generation sulfonylurea derivative still widely used as a second-line treatment for type 2 diabetes mellitus, is well known to be subject to interindividual diff... |
PMC7918143 | core_pubmed_pmc | In Vitro–In Vivo Correlation (IVIVC) Population Modeling for the In Silico Bioequivalence of a Long-Acting Release Formulation of Progesterone | In Vitro–In Vivo Correlation (IVIVC) Population Modeling for the In Silico Bioequivalence of a Long-Acting Release Formulation of Progesterone Abstract Abstract Health authorities carefully evaluate any change in the batch manufacturing process of a drug before and after regulatory approval. In the absence of an adequa... |
PMC12087690 | core_pubmed_pmc | A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development | A Comprehensive CYP2D6 Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development Abstract Abstract Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these int... |
PMC12620908 | core_pubmed_pmc | A reference tissue implementation of Simultaneous Multifactor Bayesian Analysis (SiMBA) of PET time activity curve data | A reference tissue implementation of Simultaneous Multifactor Bayesian Analysis (SiMBA) of PET time activity curve data Abstract Abstract PET analysis is conventionally performed as a two-stage process of quantification followed by analysis. We recently introduced SiMBA (Simultaneous Multifactor Bayesian Analysis), a h... |
PMC3100845 | core_pubmed_pmc | In Situ and in Vivo Study of Nasal Absorption of Paeonol in Rats | In Situ and in Vivo Study of Nasal Absorption of Paeonol in Rats Abstract The objective of this work was to study the in situ and in vivo nasal absorption of paeonol. A novel single pass in situ nasal perfusion technique was applied to examine the rate and extent of nasal absorption of paeonol by rats. Various experime... |
PMC12227521 | core_pubmed_pmc | Effect of oral contraceptive consumption timing on substrate metabolism, cognition, and exercise performance in females: a randomised controlled trial | Effect of oral contraceptive consumption timing on substrate metabolism, cognition, and exercise performance in females: a randomised controlled trial Abstract Abstract Purpose The pharmacokinetic profile of oral contraceptives (OCs) results in an acute, transient increase in circulating synthetic reproductive hormones... |
PMC5221858 | core_pubmed_pmc | 25 Years of Proton Pump Inhibitors: A Comprehensive Review | 25 Years of Proton Pump Inhibitors: A Comprehensive Review Abstract Abstract Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class ac... |
PMC7284432 | core_pubmed_pmc | Automated Real-Time Tumor Pharmacokinetic Profiling in 3D Models: A Novel Approach for Personalized Medicine | Automated Real-Time Tumor Pharmacokinetic Profiling in 3D Models: A Novel Approach for Personalized Medicine Abstract Abstract Cancer treatment often lacks individual dose adaptation, contributing to insufficient efficacy and severe side effects. Thus, personalized approaches are highly desired. Although various analyt... |
PMC7346235 | core_pubmed_pmc | In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM | In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM Abstract Natural products continue to be major sources of bioactive compounds and drug candidates not only because of their unique chemical structures but also because of their overall favorable metabolism and pharmacokinetic properties. The number... |
PMC4252094 | core_pubmed_pmc | A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population | A Semi-Physiologically Based Pharmacokinetic Pharmacodynamic Model for Glycyrrhizin-Induced Pseudoaldosteronism and Prediction of the Dose Limit Causing Hypokalemia in a Virtual Elderly Population Abstract Abstract Glycyrrhizin (GL) is a widely used food additive which can cause severe pseudoaldosteronism at high doses... |
PMC11162035 | core_pubmed_pmc | Effect of theophylline on serum and milk pharmacokinetics of tylosin following intramuscular administration in lactating goats | Effect of theophylline on serum and milk pharmacokinetics of tylosin following intramuscular administration in lactating goats Abstract Aim of the work The study was conducted to evaluate the influence of theophylline pre-treatment on serum pharmacokinetics and milk elimination of tylosin following single intramuscular... |
PMC7931041 | core_pubmed_pmc | VALTOCO ® (Diazepam Nasal Spray) for the Acute Treatment of Intermittent Stereotypic Episodes of Frequent Seizure Activity | VALTOCO ® (Diazepam Nasal Spray) for the Acute Treatment of Intermittent Stereotypic Episodes of Frequent Seizure Activity Abstract Abstract Valtoco ® is a new FDA-approved nasal spray version of diazepam indicated for the treatment of acute, intermittent, and stereotypic episodes of frequent seizure activity in epilep... |
PMC12514287 | core_pubmed_pmc | The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies | The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies Abstract Abstract Background Salvinorin A, the main psychoactive compound of Salvia divinorum, is a potent and selective kappa opioid receptor agonist. While human clinical trials remain limited, animal studies sugge... |
PMC11853079 | core_pubmed_pmc | Enhancing Stability and Bioavailability of Peptidylglycine Alpha-Amidating Monooxygenase in Circulation for Clinical Use | Enhancing Stability and Bioavailability of Peptidylglycine Alpha-Amidating Monooxygenase in Circulation for Clinical Use Abstract Abstract Peptidylglycine alpha-amidating monooxygenase (PAM) is the only enzyme known to catalyze C-terminal amidation, a final post-translational modification step essential for the biologi... |
PMC12691668 | core_pubmed_pmc | Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection | Safety, pharmacokinetics, and pharmacodynamics of the antisense oligonucleotide RO7239958 in healthy volunteers and adults with chronic hepatitis B infection Abstract ABSTRACT Poly(A) RNA polymerases D5 and D7 (PAPD5, PAPD7) are host factors that stabilize hepatitis B virus (HBV) RNA transcripts. RO7239958, a liver-tar... |
PMC7418343 | core_pubmed_pmc | Eflapegrastim, a Long‐Acting Granulocyte‐Colony Stimulating Factor for the Management of Chemotherapy‐Induced Neutropenia: Results of a Phase III Trial | Eflapegrastim, a Long‐Acting Granulocyte‐Colony Stimulating Factor for the Management of Chemotherapy‐Induced Neutropenia: Results of a Phase III Trial Abstract Abstract Background Eflapegrastim, a novel, long‐acting recombinant human granulocyte‐colony stimulating factor (rhG‐CSF), consists of a rhG‐CSF analog conjuga... |
PMC3783825 | core_pubmed_pmc | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples | Extraction and RP-HPLC determination of taxol in rat plasma, cell culture and quality control samples Abstract A rapid, sensitive, selective and validated reverse phase high-performance liquid chromatography (RP-HPLC) method for the estimation of paclitaxel in micro-sample of rat plasma and in culture of cancer cells w... |
PMC10096712 | core_pubmed_pmc | Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study | Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study Abstract Abstract There have been many attempts in pharmaceutical industries and academia to improve the pharmacokinetic characteristics of anti-tumor small-molecule drug... |
PMC10626837 | core_pubmed_pmc | Marine biomaterials in biomedical nano/micro-systems | Marine biomaterials in biomedical nano/micro-systems Abstract Marine resources in unique marine environments provide abundant, cost-effective natural biomaterials with distinct structures, compositions, and biological activities compared to terrestrial species. These marine-derived raw materials, including polysacchari... |
PMC3108707 | core_pubmed_pmc | Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections | Clinical safety and tolerability issues in use of triazole derivatives in management of fungal infections Abstract Abstract There has been an increase in the number of patients susceptible to invasive fungal infections (IFIs) leading to a greater need for effective, well tolerated, and easily administered antifungal ag... |
PMC7468531 | core_pubmed_pmc | Nanomedicine-based immunotherapy for central nervous system disorders | Nanomedicine-based immunotherapy for central nervous system disorders Abstract Abstract Central nervous system (CNS) disorders represent a broad spectrum of brain ailments with short- and long-term disabilities, and nanomedicine-based approaches provide a new therapeutic approach to treating CNS disorders. A variety of... |
PMC9608908 | core_pubmed_pmc | Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach | Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach Abstract Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim ... |
PMC11434484 | core_pubmed_pmc | A Systematic Methodology for the Identification of the Chemical Composition of the Mongolian Drug Erdun-Uril Compound Utilizing UHPLC-Q-Exactive Orbitrap Mass Spectrometry | A Systematic Methodology for the Identification of the Chemical Composition of the Mongolian Drug Erdun-Uril Compound Utilizing UHPLC-Q-Exactive Orbitrap Mass Spectrometry Abstract Abstract The traditional Mongolian medicine Erdun-Uril is a conventional combination of 29 herbs commonly used for the treatment of cerebro... |
PMC12583981 | core_pubmed_pmc | Pharmacokinetics and Bioequivalence of a Novel Extended‐Release Formulation of Methylphenidate Hydrochloride for Attention‐Deficit/Hyperactivity Disorder | Pharmacokinetics and Bioequivalence of a Novel Extended‐Release Formulation of Methylphenidate Hydrochloride for Attention‐Deficit/Hyperactivity Disorder Abstract Abstract Extended‐release (ER) formulations of the stimulant methylphenidate are commonly used to treat attention‐deficit/hyperactivity disorder in both chil... |
PMC6394813 | core_pubmed_pmc | Impact of erythrocytes on bacterial growth and antimicrobial activity of selected antibiotics | Impact of erythrocytes on bacterial growth and antimicrobial activity of selected antibiotics Abstract It has been shown that protein binding, temperature, and pH influence in vitro pharmacodynamic (PD) models. The fact that corpuscular blood compounds might also have an important impact is something which has, until n... |
PMC3108160 | core_pubmed_pmc | Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women | Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women Abstract The objective of this study was to determine the effects of vitamin D 3 plus calcium supplements (D 3 -calcium) on pharmacokinetics of isoflavones in Thai postmenopausal women. This study was an open-l... |
PMC4024412 | core_pubmed_pmc | Exploring Population Pharmacokinetic Modeling with Resampling Visualization | Exploring Population Pharmacokinetic Modeling with Resampling Visualization Abstract Abstract Background . In the last decade, population pharmacokinetic (PopPK) modeling has spread its influence in the whole process of drug research and development. While targeting the construction of the dose-concentration of a drug ... |
PMC3606044 | core_pubmed_pmc | Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development | Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development Abstract Abstract Modeling is an important tool in drug development; population modeling is a complex process requiring robust underlying procedures for ensuring clean data, appropriate computing platforms, adequate resources, and effec... |
PMC10014054 | core_pubmed_pmc | Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling | Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling Abstract Abstract Cannabidiol (CBD) is approved for treatment of seizures associated with two forms of epilepsy that become apparent in infancy or early ch... |
PMC11261186 | core_pubmed_pmc | Phase 1/2a Study of Rivoceranib, a Selective VEGFR-2 Angiogenesis Inhibitor, in Patients with Advanced Solid Tumors | Phase 1/2a Study of Rivoceranib, a Selective VEGFR-2 Angiogenesis Inhibitor, in Patients with Advanced Solid Tumors Abstract Abstract Purpose This study aimed to report the results from an early-phase study of rivoceranib, an oral tyrosine kinase inhibitor highly selective for vascular endothelial growth factor recepto... |
PMC12141302 | core_pubmed_pmc | First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect | First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect Abstract Introduction Interleukin 2 (IL-2) is essential for immune system activation. To reduce toxicity and prevent the activation of regulatory T cells (T-regs), a novel IL-2 variant containing 4-p... |
PMC12464849 | core_pubmed_pmc | 600- vs 400-mg First-Line Ribociclib in Hormone Receptor–Positive/ ERBB2 -Negative Advanced Breast Cancer | 600- vs 400-mg First-Line Ribociclib in Hormone Receptor–Positive/ ERBB2 -Negative Advanced Breast Cancer Abstract Key Points Question Does ribociclib, 400 mg, preserve efficacy with reduced toxic effects vs ribociclib, 600 mg, in hormone receptor–positive (HR + )/ ERRB2 –negative ( ERBB2 − ) advanced breast cancer? Fi... |
PMC8989418 | core_pubmed_pmc | Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models | Pharmacodynamic Parameters of Pharmacokinetic/Pharmacodynamic (PK/PD) Integration Models Abstract Pharmacokinetic/pharmacodynamic (PK/PD) integration models are used to investigate the antimicrobial activity characteristics of drugs targeting pathogenic bacteria through comprehensive analysis of the interactions betwee... |
PMC8561236 | core_pubmed_pmc | Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes | Targeting folate receptor beta on monocytes/macrophages renders rapid inflammation resolution independent of root causes Abstract Summary Provoked by sterile/nonsterile insults, prolonged monocyte mobilization and uncontrolled monocyte/macrophage activation can pose imminent or impending harm to the affected organs. Cu... |
PMC9028088 | core_pubmed_pmc | Preparation of Aditoprim Injection against Streptococcus suis in Pigs and a Dose Regimen Based on Pharmacokinetic-Pharmacodynamic Modeling | Preparation of Aditoprim Injection against Streptococcus suis in Pigs and a Dose Regimen Based on Pharmacokinetic-Pharmacodynamic Modeling Abstract In order to effectively treat the infection of Streptococcus suis and reduce the emergence of drug-resistant bacteria, an aditoprim (ADP) injection was developed in this st... |
PMC12674862 | core_pubmed_pmc | Discovery of Bioactive Properties in the Seagrass Ruppia maritima Extract: A Triplatform Assessment of Antioxidant, Antidiabetic, Antibacterial, Cytotoxic, and Analgesic Activities | Discovery of Bioactive Properties in the Seagrass Ruppia maritima Extract: A Triplatform Assessment of Antioxidant, Antidiabetic, Antibacterial, Cytotoxic, and Analgesic Activities Abstract Abstract Ruppia maritima , a seagrass, was investigated for its potential antioxidant, antidiabetic, antibacterial, cytotoxic, and... |
PMC11578129 | core_pubmed_pmc | Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women | Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women Abstract Abstract Optimal dosing in pregnant and lactating women requires an understanding of the pharmacokinetics in the mother, fetus, and breastfed infant. Physiologically‐based phar... |
PMC6618856 | core_pubmed_pmc | A Phase I Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Adults With Severe Renal Impairment and Healthy Matched Control Participants | A Phase I Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Adults With Severe Renal Impairment and Healthy Matched Control Participants Abstract Abstract This study investigates the impact of severe renal impairment on the pharmacokinetics of cabotegravir, an investigational HIV‐1 integrase inhibito... |
PMC8894976 | core_pubmed_pmc | Lower Absolute Lymphocyte Count Before Conditioning Predicts High Relapse Risk in Patients After Haploidentical Peripheral Blood Stem Cell Transplantation With Low Dose Anti-Thymocyte Globulin/Post-Transplant Cyclophosphamide for GvHD Prophylaxis | Lower Absolute Lymphocyte Count Before Conditioning Predicts High Relapse Risk in Patients After Haploidentical Peripheral Blood Stem Cell Transplantation With Low Dose Anti-Thymocyte Globulin/Post-Transplant Cyclophosphamide for GvHD Prophylaxis Abstract Abstract Standard anti-thymocyte globulin (ATG) weight-based dos... |
PMC12377746 | core_pubmed_pmc | Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients | Remote analysis and management of sweat biomarkers using a wearable microfluidic sticker in adult cystic fibrosis patients Abstract Significance This study demonstrates the feasibility and accuracy of a wearable microfluidic sweat patch (CF Patch) for remote monitoring of sweat chloride concentrations in people with cy... |
PMC10507324 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic integration of tilmicosin against Pasteurella multocida in a piglet tissue cage model | Pharmacokinetic/pharmacodynamic integration of tilmicosin against Pasteurella multocida in a piglet tissue cage model Abstract Tilmicosin is a semi-synthetic macrolide for veterinary use with strong antibacterial effect on respiratory bacteria. In this study, the pharmacokinetic/pharmacodynamic (PK/PD) integration of t... |
PMC12262095 | core_pubmed_pmc | Mechanisms of Microctis Folium in Hyperlipidemia: Integrating Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics | Mechanisms of Microctis Folium in Hyperlipidemia: Integrating Serum Pharmacochemistry, Network Pharmacology, and Transcriptomics Abstract Abstract Background Microctis Folium (MF), a traditional Chinese medicine (TCM), has shown promising effects in treating hyperlipidemia (HLP), yet its active constituents and mechani... |
PMC11785104 | core_pubmed_pmc | Improving the Safety of N,N -Dimethylacetamide (DMA) as a Potential Treatment for Preterm Birth in a Pregnant Mouse Model Using a Vaginal Nanoformulation | Improving the Safety of N,N -Dimethylacetamide (DMA) as a Potential Treatment for Preterm Birth in a Pregnant Mouse Model Using a Vaginal Nanoformulation Abstract Abstract Vaginal administration and the uterine first pass effect allow for preferential delivery of drugs to the reproductive tract. Dimethylacetamide has p... |
PMC8032916 | core_pubmed_pmc | Colistin plus Sulbactam or Fosfomycin against Carbapenem-Resistant Acinetobacter baumannii : Improved Efficacy or Decreased Risk of Nephrotoxicity? | Colistin plus Sulbactam or Fosfomycin against Carbapenem-Resistant Acinetobacter baumannii : Improved Efficacy or Decreased Risk of Nephrotoxicity? Abstract Abstract Background Acinetobacter baumannii has been recognized as a cause of nosocomial infection. To date, polymyxins, the last-resort therapeutic agents for car... |
PMC12618531 | core_pubmed_pmc | Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk | Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk Abstract Natural therapies for cardiovascular and cerebrovascular disease management often use nutraceuticals and herbal supplements to improve lipid profiles. This in-silico study examined the effects ... |
PMC12823458 | core_pubmed_pmc | Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling | Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling Abstract ABSTRACT Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared... |
PMC12226405 | core_pubmed_pmc | A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postmenopausal Osteoporosis | A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postmenopausal Osteoporosis Abstract ABSTRACT Objective The primary purpose of this study was to compare the efficacy and safety of proposed bios... |
PMC12879046 | core_pubmed_pmc | Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care | Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care Abstract Introduction Lorazepam has been used off-label for analgosedation in pediatric intensive care units (PICU) as an alternative to midazolam. While its intermediate duration of action makes it suitable for continuous sed... |
PMC8587775 | core_pubmed_pmc | Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain | Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain Abstract This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropa... |
PMC7570921 | core_pubmed_pmc | Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs | Cathepsin B-Cleavable Cyclopeptidic Chemotherapeutic Prodrugs Abstract Cyclopeptidic chemotherapeutic prodrugs (cPCPs) are macromolecular protease-sensitive doxorubicin (DOX) prodrugs synthesized from a cyclodecapeptidic scaffold, termed Regioselectively Addressable Functionalized Template (RAFT). In order to increase ... |
PMC6115517 | core_pubmed_pmc | Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder | Full-Profile Pharmacokinetic Study of High Dose Baclofen in Subjects With Alcohol Use Disorder Abstract Abstract Baclofen a gamma amino-butyric acid type B (GABA-B) receptor agonist, which has raised some interest for the treatment of alcohol use disorder (AUD), occasionally at dose up to 300 mg/d. We conducted the fir... |
PMC8740623 | core_pubmed_pmc | Open-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets | Open-Label, Phase I, Pharmacokinetic Studies in Healthy Chinese Subjects to Evaluate the Bioequivalence and Food Effect of a Novel Formulation of Abiraterone Acetate Tablets Abstract Abstract Purpose Abiraterone acetate tablets (I)(N-AbA) is a novel tablet co-formulated with the absorption enhancer sodium N-(8-[2-hydro... |
PMC9273620 | core_pubmed_pmc | Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information | Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information Abstract Abstract Many machine learning techniques provide a simple prediction for drug-drug interactions (DDIs). However, a systematically constructed database with pharmacokinetic (PK) DDI informatio... |
PMC10038042 | core_pubmed_pmc | Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions | Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions Abstract ABSTRACT Early assessment of dosing requirements should be an integral part of developability assessments for a discovery program. If a very high dose is required to achieve the desired pharmacological effect, it may ... |
PMC11919257 | core_pubmed_pmc | Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions | Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions Abstract Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitori... |
PMC12114934 | core_pubmed_pmc | Preparation of Carrier-Free Inhalable Dry Powder of Rivaroxaban Using Two-Step Milling for Lung-Targeted Delivery | Preparation of Carrier-Free Inhalable Dry Powder of Rivaroxaban Using Two-Step Milling for Lung-Targeted Delivery Abstract Background/Objectives : This study aimed to develop a dry powder inhalation (DPI) formulation of rivaroxaban (RVX) using a combination of bead milling (BM) and jet milling (JM) to enhance lung-targ... |
PMC9598183 | core_pubmed_pmc | In vitro Activity of Cefiderocol and Comparators against Carbapenem-Resistant Gram-Negative Pathogens from France and Belgium | In vitro Activity of Cefiderocol and Comparators against Carbapenem-Resistant Gram-Negative Pathogens from France and Belgium Abstract Abstract Infections with carbapenem-resistant (CR) Gram-negative (GN) pathogens have increased in many countries worldwide, leaving only few therapeutic options. Cefiderocol (CFDC) is a... |
PMC4558628 | core_pubmed_pmc | Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants | Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants Abstract Objective : Canagliflozin, a sodium-glucose co-transporter 2 inhibitor, approved for the treatment of type-2 diabetes mellitus (T2DM), is met... |
PMC4385703 | core_pubmed_pmc | Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors | Theragnostic Imaging Using Radiolabeled Antibodies and Tyrosine Kinase Inhibitors Abstract During the past decade, the efficacy of new molecular targeted drugs such as tyrosine kinase inhibitors (TKIs) and monoclonal antibodies has been proven worldwide, and molecular targeted therapies have become the mainstream in ca... |
PMC9194936 | core_pubmed_pmc | Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors | Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors Abstract Abstract Perforin is a key effector of lymphocyte-mediated cell death pathways and contributes to transplant rejection of immunologically mismatched grafts. We have developed a nov... |
PMC9325410 | core_pubmed_pmc | Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions | Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions Abstract Abstract This study was designed to assess the quantitative performance of endogenous biomarkers for organic anion transporting polypeptide (OATP) 1B1/1B3‐mediated... |
PMC8718447 | core_pubmed_pmc | Recent Research Progress of Chiral Small Molecular Antitumor-Targeted Drugs Approved by the FDA From 2011 to 2019 | Recent Research Progress of Chiral Small Molecular Antitumor-Targeted Drugs Approved by the FDA From 2011 to 2019 Abstract Chiral drugs usually contain chiral centers, which are present as single enantiomers or racemates. Compared with achiral drugs, they have significant advantages in safety and efficacy with high ste... |
PMC8504832 | core_pubmed_pmc | Modeling and simulation to predict the degree of disability over time in acute ischemic stroke patients | Modeling and simulation to predict the degree of disability over time in acute ischemic stroke patients Abstract Abstract Disability in patients with acute stroke varies over time, with the prediction of outcomes being critical for proper management. This study aimed to develop a model to predict the cumulative probabi... |
PMC5962683 | core_pubmed_pmc | Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study | Pharmacokinetics of Active Components From Guhong Injection in Normal and Pathological Rat Models of Cerebral Ischemia: A Comparative Study Abstract Background and Objectives: Guhong Injection (GHI) is usually administered for the treatment of stroke in clinics. Aceglutamide and hydroxyl safflower yellow A (HSYA) are i... |
PMC6437290 | core_pubmed_pmc | Detectable prednisolone is delayed in pericardial fluid, compared with plasma of patients with tuberculous pericarditis: A pilot study | Detectable prednisolone is delayed in pericardial fluid, compared with plasma of patients with tuberculous pericarditis: A pilot study Abstract Background In patients with tuberculous pericarditis [TBP] adjunctive prednisolone reduces the incidence of constrictive pericarditis. It is unknown whether prednisolone permea... |
PMC7509924 | core_pubmed_pmc | Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation | Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation Abstract Background The root of Angelica gigas Nakai (Apiaceae) has been traditionally used as an important herbal medicine to treat blood-deficiency-related disorders in Eastern Asian count... |
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