id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC11842995 | core_pubmed_pmc | Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors | Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors Abstract Abstract E7766 is a novel stimulator of interferon genes (STING) agonist, capable of potent activation of immune cells and generating strong antitumor response in preclinical murine tumor models. Here we present t... |
PMC11329366 | core_pubmed_pmc | First‐in‐human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor | First‐in‐human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor Abstract Abstract Dysregulation of the mineralocorticoid hormone aldosterone is an increasingly prevalent cause of hypertension. Aldosterone synthase (CYP11B2) shar... |
PMC11141581 | core_pubmed_pmc | Mechanism of Qiguiyin Decoction Sensitizing Levofloxacin Against Multidrug-Resistant Pseudomonas aeruginosa Infection Based on PK-PD and Antibody Chip Technology | Mechanism of Qiguiyin Decoction Sensitizing Levofloxacin Against Multidrug-Resistant Pseudomonas aeruginosa Infection Based on PK-PD and Antibody Chip Technology Abstract Background Qiguiyin decoction (QGYD) is a traditional Chinese medicine (TCM) and its combined application with levofloxacin (LVFX) has been confirmed... |
PMC8923173 | core_pubmed_pmc | Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections | Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections Abstract ABSTRACT Antibiotics are the current standard-of-care treatment for uncomplicated urinary tract infections (uUTIs). However, increasing rates of bacterial antibiotic resistanc... |
PMC12246403 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic characterization of remimazolam in older Japanese adults who underwent general anesthesia at early stage of infusion | Pharmacokinetic and pharmacodynamic characterization of remimazolam in older Japanese adults who underwent general anesthesia at early stage of infusion Abstract The pharmacokinetic and pharmacodynamic characteristics of remimazolam (RMZ), a novel ultrashort-acting anesthetic, administration alone in clinical practice ... |
PMC4173659 | core_pubmed_pmc | Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor | Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor Abstract Abstract B-cell activating factor (BAFF) is a B-cell survival factor with a key role in B-cell homeostasis and tolerance. Dysregulated BAFF expression may contribu... |
PMC11056802 | core_pubmed_pmc | The Rise of Remimazolam: A Review of Pharmacology, Clinical Efficacy, and Safety Profiles | The Rise of Remimazolam: A Review of Pharmacology, Clinical Efficacy, and Safety Profiles Abstract Anesthesiologists often use benzodiazepines (BZDs) due to their remarkable amnestic and anxiolytic capabilities. Because of this, they are perfect for use during the perioperative phase, when patients' anxiety levels are ... |
PMC10092046 | core_pubmed_pmc | The Role of PD Biomarkers in Biosimilar Development – To Get the Right Answer One Must First Ask the Right Question | The Role of PD Biomarkers in Biosimilar Development – To Get the Right Answer One Must First Ask the Right Question Abstract Abstract The potential for pharmacodynamic (PD) biomarkers to improve the efficiency of biosimilar product development and regulatory approval formed the premise for the virtual workshop Pharmaco... |
PMC7496923 | core_pubmed_pmc | Utility of systemic voriconazole in equine keratomycosis based on pharmacokinetic‐pharmacodynamic analysis of tear fluid following oral administration | Utility of systemic voriconazole in equine keratomycosis based on pharmacokinetic‐pharmacodynamic analysis of tear fluid following oral administration Abstract Abstract Objective To clarify the detailed pharmacokinetics (PK) of orally administered voriconazole in tear fluid (TF) of horses for evaluating the efficacy of... |
PMC7415763 | core_pubmed_pmc | A comparison of thyroidal protection by stable iodine or perchlorate in the case of acute or prolonged radioiodine exposure | A comparison of thyroidal protection by stable iodine or perchlorate in the case of acute or prolonged radioiodine exposure Abstract In the case of a nuclear power plant accident, repetitive/prolonged radioiodine release may occur. Radioiodine accumulates in the thyroid and by irradiation enhances the risk of cancer. L... |
PMC11561734 | core_pubmed_pmc | Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency | Population Pharmacokinetic/Pharmacodynamic Study of Linezolid in Hospital-Acquired Pneumonia Patients with Renal Insufficiency Abstract Purpose The optimal treatment strategy in patients with hospital-acquired pneumonia (HAP) due to Gram-positive bacteria and renal insufficiency remains challenging. The objective of th... |
PMC7455751 | core_pubmed_pmc | Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury | Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury Abstract Abstract Purpose Baicalin (BA) has a good neuroprotective effect, but it is eliminated quickly in the body and does not easily reach the brain. In this experiment, borneol (BO) wa... |
PMC9473365 | core_pubmed_pmc | Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis | Use of the SGLT2 inhibitor canagliflozin for control of refractory equine hyperinsulinemia and laminitis Abstract Abstract Background: Hyperinsulinemia associated with pituitary pars intermedia dysfunction (PPID) and/or equine metabolic syndrome is well documented to put horses at high risk of laminitis. While dietary ... |
PMC6616205 | core_pubmed_pmc | Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration | Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration Abstract Abstract Background and Objectives The number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by a... |
PMC9122503 | core_pubmed_pmc | Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Red Softgels in Healthy Participants | Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Red Softgels in Healthy Participants Abstract Abstract Due to a lack of published pharmacokinetic (PK) and/or pharmacodynamic (PD) data, informed physician and patient decision-making surrounding appropriate dosing of cannabis for medical purposes is limited. Th... |
PMC3224475 | core_pubmed_pmc | Renal and neurological side effects of colistin in critically ill patients | Renal and neurological side effects of colistin in critically ill patients Abstract Abstract Colistin is a complex polypeptide antibiotic composed mainly of colistin A and B. It was abandoned from clinical use in the 1970s because of significant renal and, to a lesser extent, neurological toxicity. Actually, colistin i... |
PMC10716330 | core_pubmed_pmc | Computer-aided identification of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) inhibitors from Gymnema sylvestre natural products | Computer-aided identification of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) inhibitors from Gymnema sylvestre natural products Abstract Abstract Tuberculosis (TB), an infectious disease caused by multi-drug resistant Mycobacterium tuberculosis (Mtb), has been a global health concern. Mtb affects... |
PMC4646778 | core_pubmed_pmc | Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase | Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase Abstract Abstract Antigen-specific immune responses to protein drugs can hinder efficacy and compromise safety because of drug neutralization and secondary clinical complications. We report a tolerance induction strategy to preve... |
PMC11206427 | core_pubmed_pmc | Renal Replacement Therapy as a New Indicator of Voriconazole Clearance in a Population Pharmacokinetic Analysis of Critically Ill Patients | Renal Replacement Therapy as a New Indicator of Voriconazole Clearance in a Population Pharmacokinetic Analysis of Critically Ill Patients Abstract Abstract Aims: The pharmacokinetic (PK) profiles of voriconazole in intensive care unit (ICU) patients differ from that in other patients. We aimed to develop a population ... |
PMC9797042 | core_pubmed_pmc | Outcomes of modern antiretroviral therapy in obese individuals living with HIV | Outcomes of modern antiretroviral therapy in obese individuals living with HIV Abstract Abstract Obesity is a global epidemic and people living with HIV (PLWH) are showing similar obesity trends to those in the general population. Obesity is manifested by several physiological features that can alter volume of distribu... |
PMC12629108 | core_pubmed_pmc | Subcutaneous injections of cabotegravir plus rilpivirine long-acting in virally suppressed adults with HIV-1 | Subcutaneous injections of cabotegravir plus rilpivirine long-acting in virally suppressed adults with HIV-1 Abstract Abstract Objective: To evaluate subcutaneous anterior abdominal injections of long-acting cabotegravir plus rilpivirine (CAB + RPV LA) in participants with more than 3 years’ experience with intramuscul... |
PMC9112930 | core_pubmed_pmc | Exposure–Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP | Exposure–Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP Abstract ABSTRACT An exposure–efficacy analysis of the phase 3 ASPECT-NP trial was performed to evaluate the relationship between plasma expo... |
PMC9025148 | core_pubmed_pmc | Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp ( Ctenopharyngodon idella ) at Different Temperatures after Oral Administration | Comparative Pharmacokinetics of Sulfadiazine and Its Metabolite N4-Acetyl Sulfadiazine in Grass Carp ( Ctenopharyngodon idella ) at Different Temperatures after Oral Administration Abstract In this study, the plasma pharmacokinetics and tissue disposition of sulfadiazine (SDZ) and its main metabolite, N 4 -acetyl sulfa... |
PMC9257742 | core_pubmed_pmc | iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System | iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System Abstract Abstract For oral drugs, the formulator and discovery chemist have a tool available to them that can be used to navigate the risks associated with the selection and development of immediate release oral drugs and dr... |
PMC7558518 | core_pubmed_pmc | Evaluation of Intravenous Fosfomycin Disodium Dosing Regimens in Critically Ill Patients for Treatment of Carbapenem-Resistant Enterobacterales Infections Using Monte Carlo Simulation | Evaluation of Intravenous Fosfomycin Disodium Dosing Regimens in Critically Ill Patients for Treatment of Carbapenem-Resistant Enterobacterales Infections Using Monte Carlo Simulation Abstract Abstract There are limited intravenous fosfomycin disodium (IVFOS) dosing regimens to treat carbapenem-resistant Enterobacteral... |
PMC5055047 | core_pubmed_pmc | Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers | Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers Abstract Background According to prescribing information for Myrtol standardized enteric-coated so... |
PMC9865866 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing Escherichia coli and Klebsiella pneumoniae | Pharmacokinetic/Pharmacodynamic Evaluation of Aztreonam/Amoxicillin/Clavulanate Combination against New Delhi Metallo-β-Lactamase and Serine-β-Lactamase Co-Producing Escherichia coli and Klebsiella pneumoniae Abstract Abstract This study aimed to examine specific niches and usage for the aztreonam/amoxicillin/clavulana... |
PMC6366143 | core_pubmed_pmc | Three patients with injection of intravitreal vascular endothelial growth factor inhibitors and subsequent exacerbation of chronic proteinuria and hypertension | Three patients with injection of intravitreal vascular endothelial growth factor inhibitors and subsequent exacerbation of chronic proteinuria and hypertension Abstract Abstract Vascular endothelial growth factor (VEGF) receptor inhibition is a commonly used tool to prevent vascular proliferation in tumors and retinal ... |
PMC4853790 | core_pubmed_pmc | In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy | In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy Abstract Moxifloxacin and gatifloxacin are fourth-generation fluoroquinolone antibiotics used in the clinic to prevent or treat ocular infections. Their pharmacokinetics in the cornea is usually measur... |
PMC11725257 | core_pubmed_pmc | A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects | A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in Healthy Adult Subjects Abstract Background YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma expos... |
PMC7029911 | core_pubmed_pmc | Spectroscopic and molecular docking studies reveal binding characteristics of nazartinib (EGF816) to human serum albumin | Spectroscopic and molecular docking studies reveal binding characteristics of nazartinib (EGF816) to human serum albumin Abstract Abstract The interactions of novel anti-cancer therapeutic agents with the different plasma and tissue components, specifically serum albumins, have lately gained considerable attention due ... |
PMC4074692 | core_pubmed_pmc | Anticoagulant therapy in pediatrics | Anticoagulant therapy in pediatrics Abstract Abstract Thromboembolic episodes are disorders encountered in both children and adults, but relatively more common in adults. However, the occurrence of venous thromboembolism and use of anticoagulants in pediatrics are increasing. Unfractionated Heparin (UH) is used as a tr... |
PMC12001254 | core_pubmed_pmc | Population Pharmacokinetics and Exposure‐Response of Subcutaneous Atezolizumab in Patients With Non‐Small Cell Lung Cancer | Population Pharmacokinetics and Exposure‐Response of Subcutaneous Atezolizumab in Patients With Non‐Small Cell Lung Cancer Abstract ABSTRACT IMscin001 is a two‐part dose‐finding (Phase Ib) and ‐confirmation (Phase III) study to evaluate atezolizumab pharmacokinetics of subcutaneous (SC) compared with intravenous (IV) a... |
PMC9574745 | core_pubmed_pmc | An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis | An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis Abstract Abstract The efficacy of ponesimod and teriflunomide for the treatment of relapsing multiple sclerosis (MS) was compared in a randomized phase III trial. This study explore... |
PMC10766039 | core_pubmed_pmc | Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow | Predicting complex kidney drug handling using a physiologically‐based pharmacokinetic model informed by biomarker‐estimated secretory clearance and blood flow Abstract Abstract Kidney function‐adjusted drug dosing is currently based solely on the estimated glomerular filtration rate (GFR), however, kidney drug handling... |
PMC12086683 | core_pubmed_pmc | Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis | Individualization of piperacillin dosage based on therapeutic drug monitoring with or without model-informed precision dosing: a scenario analysis Abstract Abstract Background Model-informed precision dosing (MIPD) combines population pharmacokinetic knowledge with therapeutic drug monitoring (TDM) to optimize dosage a... |
PMC8376145 | core_pubmed_pmc | Multiscale model of hepatitis C virus dynamics in plasma and liver following combination therapy | Multiscale model of hepatitis C virus dynamics in plasma and liver following combination therapy Abstract Abstract This work explores the application of a physiologically structured population (PSP) framework in modeling hepatitis C virus (HCV) kinetics. To do so, a model was developed for the viral RNA load in plasma ... |
PMC4937627 | core_pubmed_pmc | Occurrence of drug–drug interactions in Adama Referral Hospital, Adama city, Ethiopia | Occurrence of drug–drug interactions in Adama Referral Hospital, Adama city, Ethiopia Abstract Abstract Objective Many medications have potential interactions with other drugs or substances when prescribed together. This study was intended to investigate the extent of poly-pharmacy, event of drug–drug interactions and ... |
PMC12498006 | core_pubmed_pmc | Anaesthesia Challenges in Patients With Chronic Kidney Disease: A Clinical Approach From Internal Medicine | Anaesthesia Challenges in Patients With Chronic Kidney Disease: A Clinical Approach From Internal Medicine Abstract Chronic kidney disease (CKD) poses significant challenges for perioperative anaesthetic management due to complex alterations in drug clearance, fluid and electrolyte balance, and increased cardiovascular... |
PMC10892643 | core_pubmed_pmc | Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing | Population Pharmacokinetic Model of Linezolid and Probability of Target Attainment in Patients with COVID-19-Associated Acute Respiratory Distress Syndrome on Veno-Venous Extracorporeal Membrane Oxygenation—A Step toward Correct Dosing Abstract Abstract During veno-venous extracorporeal membrane oxygenation (vv ECMO) t... |
PMC5445229 | core_pubmed_pmc | Population Pharmacokinetics of Morphine in Patients With Nonalcoholic Steatohepatitis (NASH) and Healthy Adults | Population Pharmacokinetics of Morphine in Patients With Nonalcoholic Steatohepatitis (NASH) and Healthy Adults Abstract Altered expression and function of transporters in nonalcoholic steatohepatitis (NASH) patients may affect the pharmacokinetics (PK), efficacy, and safety of substrate drugs. A population pharmacokin... |
PMC4542398 | core_pubmed_pmc | Development, validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of rosuvastatin and metformin in human plasma and its application to a pharmacokinetic study | Development, validation of liquid chromatography-tandem mass spectrometry method for simultaneous determination of rosuvastatin and metformin in human plasma and its application to a pharmacokinetic study Abstract Abstract A new, simple and accurate liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for s... |
PMC8302239 | core_pubmed_pmc | Population pharmacokinetics and exposure–response analyses of varenicline in adolescent smokers | Population pharmacokinetics and exposure–response analyses of varenicline in adolescent smokers Abstract Abstract Varenicline is an approved smoking cessation aid in adults. Population pharmacokinetics (popPK) and exposure–response (ER) (continuous abstinence rates [CAR] weeks 9‒12 and nausea/vomiting incidence) for va... |
PMC4248610 | core_pubmed_pmc | Lower Loading Dose of Prasugrel Compared with Conventional Loading Doses of Clopidogrel and Prasugrel in Korean Patients Undergoing Elective Coronary Angiography: A Randomized Controlled Study Evaluating Pharmacodynamic Efficacy | Lower Loading Dose of Prasugrel Compared with Conventional Loading Doses of Clopidogrel and Prasugrel in Korean Patients Undergoing Elective Coronary Angiography: A Randomized Controlled Study Evaluating Pharmacodynamic Efficacy Abstract Background and Objectives Although prasugrel allows for rapid and potent platelet ... |
PMC6921164 | core_pubmed_pmc | Determining therapeutic trough ranges for linezolid | Determining therapeutic trough ranges for linezolid Abstract Abstract Linezolid (LZD) is an oxazolidinone approved for the treatment of gram-positive infections. Therapeutic drug monitoring is increasingly used to optimize LZD dosing. The therapeutic target for LZD is to achieve an area under the concentration-time cur... |
PMC12506672 | core_pubmed_pmc | A phase I study of HEC73543, an oral FLT3 inhibitor: the effect of food on pharmacokinetics after oral dosing in healthy Chinese volunteers | A phase I study of HEC73543, an oral FLT3 inhibitor: the effect of food on pharmacokinetics after oral dosing in healthy Chinese volunteers Abstract Objective This study evaluated the effect of food on the pharmacokinetics (PK) and safety of HEC73543. Methods This randomized, open-label, single-dose, phase I parallel t... |
PMC9721384 | core_pubmed_pmc | Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis | Addition of probenecid to oral β-lactam antibiotics: a systematic review and meta-analysis Abstract Abstract Objectives To explore the literature comparing the pharmacokinetic and clinical outcomes from adding probenecid to oral β-lactams. Methods Medline and EMBASE were searched from inception to December 2021 for all... |
PMC6767536 | core_pubmed_pmc | A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects | A Randomized, Double‐Blind, Placebo‐Controlled, First‐Time‐in‐Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of GSK3389404 in Healthy Subjects Abstract Abstract GSK3389404 is a liver‐targeted antisense oligonucleotide that inhibits synthesis of hepatitis B su... |
PMC11372714 | core_pubmed_pmc | In vitro antibacterial activity of danofloxacin against Escherichia coli isolated from pigeons and its pharmacokinetic in pigeons | In vitro antibacterial activity of danofloxacin against Escherichia coli isolated from pigeons and its pharmacokinetic in pigeons Abstract Abstract This experiment aimed to investigate the in vitro antimicrobial activity of danofloxacin against Escherichia coli ( E. coli ) isolated from pigeons, as well as the pharmaco... |
PMC8246884 | core_pubmed_pmc | Short‐duration treatment with the novel non‐nucleoside inhibitor CDI‐31244 plus sofosbuvir/velpatasvir for chronic hepatitis C: An open‐label study | Short‐duration treatment with the novel non‐nucleoside inhibitor CDI‐31244 plus sofosbuvir/velpatasvir for chronic hepatitis C: An open‐label study Abstract Abstract Combination regimens of direct‐acting antiviral agents (DAAs) for chronic genotype 1 hepatitis C virus (HCV) infection given for 8 or 12 weeks have high c... |
PMC6830151 | core_pubmed_pmc | Use of classification and regression tree (CART), to identify hemoglobin A1C (HbA 1C ) cut-off thresholds predictive of poor tuberculosis treatment outcomes and associated risk factors | Use of classification and regression tree (CART), to identify hemoglobin A1C (HbA 1C ) cut-off thresholds predictive of poor tuberculosis treatment outcomes and associated risk factors Abstract Background Rifampin-based therapy potentially exacerbates glycemic control among TB patients who are already at high risk of h... |
PMC12193388 | core_pubmed_pmc | Sugar-Linked Diethyldithiocarbamate Derivatives: A Novel Class of Anticancer Agents | Sugar-Linked Diethyldithiocarbamate Derivatives: A Novel Class of Anticancer Agents Abstract Disulfiram (DSF), a well-known anti-alcoholism drug, exhibits potent anticancer activity via its metabolite, diethyldithiocarbamate (DDC), which forms a cytotoxic copper complex that selectively targets cancer stem cells. Howev... |
PMC9270274 | core_pubmed_pmc | Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines | Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines Abstract Abstract Purpose Noonan syndrome with multiple lentigines (NSML) is an autosomal dominant disorder presenting with hypertrophic cardiomyopathy (HCM). Up to 85% of NSML cases are caused by mutations in the PTP... |
PMC12186298 | core_pubmed_pmc | Phase 1 clinical trial of eneboparatide, a novel PTH receptor 1 agonist | Phase 1 clinical trial of eneboparatide, a novel PTH receptor 1 agonist Abstract Abstract Objective This study evaluated the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of eneboparatide (AZP-3601), a novel agonist of the PTH receptor 1 developed for the treatment of hypoparathyroidism. Design ... |
PMC12847137 | core_pubmed_pmc | Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies | Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies Abstract Medulloblastomas are the most common malignant pediatric brain tumors, representing approximately 20% of the central nervous system cancers in children. These tumors are highly heterogeneous and classified into... |
PMC8958608 | core_pubmed_pmc | Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab Vedotin | Hodgkin Lymphoma on Hemodialysis Successfully Treated with Extended Courses of Brentuximab Vedotin Abstract Chemotherapy for hemodialysis (HD) patients is a challenging situation because HD patients are generally frail, and the pharmacokinetics and pharmacodynamics of most chemotherapeutics in HD patients are unknown. ... |
PMC11954719 | core_pubmed_pmc | Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin | Influence of a Short Course of Ritonavir Used as Booster in Antiviral Therapies Against SARS-CoV-2 on the Exposure of Atorvastatin and Rosuvastatin Abstract Purpose Early antiviral treatment with nirmatrelvir/ritonavir is recommended for SARS-CoV-2-infected patients at high risk for severe courses. Such patients are us... |
PMC7566547 | core_pubmed_pmc | High in vitro activity of DIS-73285, a novel antimicrobial with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae | High in vitro activity of DIS-73285, a novel antimicrobial with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae Abstract Abstract Background The rising incidence of antimicrobial resistance in Neisseria gonorrhoeae may result in untreatable gonorrhoea in certain circumstances and development of nov... |
PMC7253354 | core_pubmed_pmc | Drug–drug–gene interactions and adverse drug reactions | Drug–drug–gene interactions and adverse drug reactions Abstract The economic and health burden caused by adverse drug reactions has increased dramatically in the last few years. This is likely to be mediated by increasing polypharmacy, which increases the likelihood for drug–drug interactions. Tools utilized by healthc... |
PMC10497203 | core_pubmed_pmc | Population Pharmacokinetic Modeling and Determination of Individual Exposure to Avalglucosidase Alfa in Adolescent and Adult Patients With Late-Onset Pompe Disease: Analysis of Pooled Data From Phase I to III Clinical Trials | Population Pharmacokinetic Modeling and Determination of Individual Exposure to Avalglucosidase Alfa in Adolescent and Adult Patients With Late-Onset Pompe Disease: Analysis of Pooled Data From Phase I to III Clinical Trials Abstract Abstract Background: Pompe disease is a rare genetic disorder caused by a deficiency o... |
PMC9484246 | core_pubmed_pmc | Intratumoral delivery of TransCon ™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction | Intratumoral delivery of TransCon ™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction Abstract Background Intratumoral (IT) delivery of toll-like receptor (TLR) agonists has shown encouraging anti-tumor benefit in preclinical and early cl... |
PMC8846400 | core_pubmed_pmc | Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development | Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development Abstract ABSTRACT The emergence and spread of parasite resistance to currently available antimalarials has highlighted the importance of developing novel antimalarials. This scoping review provides an overview of antimalarial drug candida... |
PMC6146668 | core_pubmed_pmc | Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis : In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration | Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis : In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration Abstract Abstract Realgar and indigo naturalis are clinically combined to treat varieties of leukemia. Exploring the drug-drug i... |
PMC3702506 | core_pubmed_pmc | Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations | Importance of Ethnicity, CYP2B6 and ABCB1 Genotype for Efavirenz Pharmacokinetics and Treatment Outcomes: A Parallel-Group Prospective Cohort Study in Two Sub-Saharan Africa Populations Abstract Objectives We evaluated the importance of ethnicity and pharmacogenetic variations in determining efavirenz pharmacokinetics,... |
PMC12951560 | core_pubmed_pmc | Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome | Bioisostere-Driven Discovery of SePP: A Selenium-Containing Polypharmacological Agent Relevant to Fragile X Syndrome Abstract Abstract Diphenidine is a prototypical 1,2-diarylethylamine that functions as an uncompetitive N -methyl- d -aspartate receptor (NMDAR) antagonist and monoamine reuptake inhibitor. To examine th... |
PMC8539387 | core_pubmed_pmc | Impact of Tacrolimus Daily Dose Limitation in Renal Transplant Recipients Expressing CYP3A5: A Retrospective Study | Impact of Tacrolimus Daily Dose Limitation in Renal Transplant Recipients Expressing CYP3A5: A Retrospective Study Abstract Abstract The pharmacokinetic variability of tacrolimus can be partly explained by CYP3A5 activity. Our objective was to evaluate a tacrolimus sparing policy on renal graft outcome according to CYP... |
PMC11494959 | core_pubmed_pmc | Delivery strategies to improve piglets exposure to oral antimicrobials | Delivery strategies to improve piglets exposure to oral antimicrobials Abstract Background The widespread practice of delivering antimicrobials through drinking water to livestock leads to considerable variability in exposure levels among animals, raising concerns regarding disease outbreaks and the emergence of antimi... |
PMC5298089 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects | Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects Abstract Abstract This phase 1 trial evaluated pharmacokinetic and pharmacodynamic interactions between the novel triazole antifungal agent isavuconazole and warfarin in healthy adults. Mul... |
PMC12809580 | core_pubmed_pmc | An Observational Cohort Study of Targeted Antibiotic Treatments of Cystic Fibrosis Exacerbations | An Observational Cohort Study of Targeted Antibiotic Treatments of Cystic Fibrosis Exacerbations Abstract Abstract Background Cystic fibrosis (CF) pulmonary exacerbations shorten survival. Treatment guidelines omit minimal inhibitory concentration (MIC)–based antibiotic dose selection. We tested whether MIC-guided intr... |
PMC10508611 | core_pubmed_pmc | A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects | A randomized trial: The safety, pharmacokinetics and preliminary pharmacodynamics of ropivacaine oil delivery depot in healthy subjects Abstract Introduction Ropivacaine oil delivery depot (RODD) can slowly release ropivacaine and block nerves for a long timejavascript:;. The aim of the present work was to investigate ... |
PMC12854050 | core_pubmed_pmc | pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy | pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy Abstract Abstract Gastric cancer (GC) remains a major global health burden, with limited effective therapies and poor prognosis. Quercetin (Que), a natural flavonoid, exhibits anticancer activity but suffers from poor wate... |
PMC9805152 | core_pubmed_pmc | Efficacy, safety and bioequivalence of the human‐derived B‐domain‐deleted recombinant factor VIII TQG202 for prophylaxis in severe haemophilia A patients | Efficacy, safety and bioequivalence of the human‐derived B‐domain‐deleted recombinant factor VIII TQG202 for prophylaxis in severe haemophilia A patients Abstract Abstract Introduction Current treatment of severe haemophilia A includes prophylaxis with factor VIII (FVIII) replacement. The supply of plasma‐derived FVIII... |
PMC10002493 | core_pubmed_pmc | Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies | Direct Oral FXa Inhibitors Binding to Human Serum Albumin: Spectroscopic, Calorimetric, and Computational Studies Abstract Abstract Direct FXa inhibitors are an important class of bioactive molecules (rivaroxaban, apixaban, edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular pathologies. ... |
PMC8799559 | core_pubmed_pmc | Population Pharmacokinetics and Exposure–Response Analyses for Venetoclax in Combination with R-CHOP in Relapsed/Refractory and Previously Untreated Patients with Diffuse Large B Cell Lymphoma | Population Pharmacokinetics and Exposure–Response Analyses for Venetoclax in Combination with R-CHOP in Relapsed/Refractory and Previously Untreated Patients with Diffuse Large B Cell Lymphoma Abstract Introduction Outcomes remain poor in patients with diffuse large B cell lymphoma (DLBCL) who overexpress BCL-2 protein... |
PMC11787893 | core_pubmed_pmc | Simulated achievement rate of β-lactams/nacubactam treatment in humans using instantaneous MIC-based PK/PD analysis | Simulated achievement rate of β-lactams/nacubactam treatment in humans using instantaneous MIC-based PK/PD analysis Abstract Abstract Background Nacubactam (NAC), a new diazabicyclooctane β-lactamase inhibitor, is being developed for use together with aztreonam (AZT) and cefepime (CFPM). However, the effective clinical... |
PMC3916804 | core_pubmed_pmc | The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice | The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice Abstract Abstract Background Malaria is one of the most lethal and life-threatening killer infectious diseases in the world, and... |
PMC9574830 | core_pubmed_pmc | Targeting COVID-19 pandemic: in silico evaluation of 2-hydroxy-1, 2-diphenylethanone N(4)-methyl-N(4)-phenylthiosemicarbazone as a potential inhibitor of SARS-CoV-2 | Targeting COVID-19 pandemic: in silico evaluation of 2-hydroxy-1, 2-diphenylethanone N(4)-methyl-N(4)-phenylthiosemicarbazone as a potential inhibitor of SARS-CoV-2 Abstract The global spread of the COVID-19 pandemic caused by the etiological agent, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), triggere... |
PMC6096899 | core_pubmed_pmc | Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach | Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach Abstract Purpose Changes in drug absorption and first-pass metabolism have been reported throughout the pediatric age range. Our aim is to characterize both i... |
PMC11341832 | core_pubmed_pmc | Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers | Novel cathepsin C inhibitor, BI 1291583, intended for treatment of bronchiectasis: Phase I characterization in healthy volunteers Abstract Abstract Novel treatments are needed to reduce inflammation, improve symptoms, address exacerbations, and slow disease progression in bronchiectasis. Cathepsin C (CatC) inhibition p... |
PMC10910237 | core_pubmed_pmc | Pharmacokinetics of single dose doxycycline in the rectum, vagina, and urethra: implications for prevention of bacterial sexually transmitted infections | Pharmacokinetics of single dose doxycycline in the rectum, vagina, and urethra: implications for prevention of bacterial sexually transmitted infections Abstract Summary Background Clinical trials showed a single oral dose of doxycycline taken after sex protects against STIs among men who have sex with men (MSM) but no... |
PMC10369431 | core_pubmed_pmc | Cefepime extended infusion versus intermittent infusion: Clinical and cost evaluation | Cefepime extended infusion versus intermittent infusion: Clinical and cost evaluation Abstract Abstract Background: Extended infusion cefepime (1 gram every 6 hours administered over 3 hours) achieves pharmacodynamic efficacy against bacteria with a MIC of ≤8 mg/L in Monte Carlo simulations. This regimen has not been e... |
PMC12519588 | core_pubmed_pmc | Oral nanoliposomes functionalized with cRGD and polydopamine for enhanced antimalarial efficacy of disulfide bond-modified dihydroartemisinin prodrug | Oral nanoliposomes functionalized with cRGD and polydopamine for enhanced antimalarial efficacy of disulfide bond-modified dihydroartemisinin prodrug Abstract Abstract Malaria remains a global health crisis, with Plasmodium resistance underscoring the urgent need for advanced drug delivery strategies. To overcome the l... |
PMC10954945 | core_pubmed_pmc | Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates | Bayesian Vancomycin Model Selection for Therapeutic Drug Monitoring in Neonates Abstract Background and Objective Pharmacokinetic models can inform drug dosing of vancomycin in neonates to optimize therapy. However, the model selected needs to describe the intended population to provide appropriate dose recommendations... |
PMC11695905 | core_pubmed_pmc | Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections | Model-informed drug development for antimicrobials: translational pharmacokinetic-pharmacodynamic modelling of apramycin to facilitate prediction of efficacious dose in complicated urinary tract infections Abstract Abstract Objectives The use of mouse models of complicated urinary tract infection (cUTI) has usually bee... |
PMC12110727 | core_pubmed_pmc | Capillary Filtration of Plasma Is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis | Capillary Filtration of Plasma Is Accelerated During General Anesthesia: A Secondary Population Volume Kinetic Analysis Abstract Abstract How infusion fluids are distributed and eliminated is of importance to how much and how fast they should be administered. This manuscript applies population pharmacokinetic modeling ... |
PMC11375879 | core_pubmed_pmc | Antibiotic resistance challenge: evaluating anthraquinones as rifampicin monooxygenase inhibitors through integrated bioinformatics analysis | Antibiotic resistance challenge: evaluating anthraquinones as rifampicin monooxygenase inhibitors through integrated bioinformatics analysis Abstract Abstract Objective Antibiotic resistance poses a pressing and crucial global public health challenge, leading to significant clinical and health-related consequences. Sub... |
PMC9326111 | core_pubmed_pmc | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer | Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer Abstract Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is one of the most important natural products in the genus Capsicum. Due to its numerous biological effects, there has been extensive and increasing research... |
PMC11325272 | core_pubmed_pmc | Safety and clinical activity of durvalumab combined with tremelimumab in recurrent/metastatic head and neck squamous cell carcinoma: a multicenter phase I study | Safety and clinical activity of durvalumab combined with tremelimumab in recurrent/metastatic head and neck squamous cell carcinoma: a multicenter phase I study Abstract Abstract Background Programmed cell death protein 1 (PD-1) inhibitors prolong survival versus chemotherapy in recurrent/metastatic head and neck squam... |
PMC9414514 | core_pubmed_pmc | In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A | In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A Abstract In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, precl... |
PMC5326936 | core_pubmed_pmc | Pharmacokinetic studies of the recombinant chicken interferon-α in broiler chickens | Pharmacokinetic studies of the recombinant chicken interferon-α in broiler chickens Abstract Abstract In this study, 24 male and female broiler chickens at 30-day-old were divided into three groups with 8 animals in each group. The animals were administered with recombinant chicken interferon-α (rChIFN-α) at a dose of ... |
PMC10051608 | core_pubmed_pmc | Multi-Compartmental Dissolution Method, an Efficient Tool for the Development of Enhanced Bioavailability Formulations Containing Poorly Soluble Acidic Drugs | Multi-Compartmental Dissolution Method, an Efficient Tool for the Development of Enhanced Bioavailability Formulations Containing Poorly Soluble Acidic Drugs Abstract Abstract The purpose of this study was to investigate the applicability of the Gastrointestinal Simulator (GIS), a multi-compartmental dissolution model,... |
PMC11879141 | core_pubmed_pmc | Quantitative evaluation of multiple treatment regimens for treatment-resistant depression | Quantitative evaluation of multiple treatment regimens for treatment-resistant depression Abstract Abstract Objective This study aims to quantitatively evaluate the efficacy and safety of various treatment regimens for treatment-resistant depression (TRD) across oral, intravenous, and intranasal routes to inform clinic... |
PMC11881764 | core_pubmed_pmc | Dose optimization of cefazolin in South African children undergoing cardiac surgery with cardiopulmonary bypass | Dose optimization of cefazolin in South African children undergoing cardiac surgery with cardiopulmonary bypass Abstract Abstract Cefazolin is an antibiotic used to prevent surgical site infections. During cardiac surgery with cardiopulmonary bypass (CPB), its efficacy target could be underachieved. We aimed to develop... |
PMC8979758 | core_pubmed_pmc | Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information | Prediction of metabolizing enzyme-mediated clinical drug interactions using in vitro information Abstract Abstract Evaluation of drug interactions is an essential step in the new drug development process. Regulatory agencies, including U.S. Food and Drug Administrations and European Medicines Agency, have been publishe... |
PMC12117050 | core_pubmed_pmc | Effects of mallotus furetianus extract on CYP3A activities in rats | Effects of mallotus furetianus extract on CYP3A activities in rats Abstract Mallotus furetianus is traditionally used as folk medicine on Hainan Island, China. Given the significance of the pharmacokinetic interaction between herbs and drugs, we investigated the effects of Mallotus furetianus ethanol extract (MFE) on C... |
PMC11335710 | core_pubmed_pmc | Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders | Sitagliptin elevates plasma and CSF incretin levels following oral administration to nonhuman primates: relevance for neurodegenerative disorders Abstract The endogenous incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) possess neurotrophic, neuroprotective, and anti-neuro... |
PMC10689135 | core_pubmed_pmc | Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor | Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor Abstract ABSTRACT People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions res... |
PMC9686941 | core_pubmed_pmc | Empirical Antibiotic Therapy for Gram-Negative Bacilli Ventilator-Associated Pneumonia: Observational Study and Pharmacodynamic Assessment | Empirical Antibiotic Therapy for Gram-Negative Bacilli Ventilator-Associated Pneumonia: Observational Study and Pharmacodynamic Assessment Abstract Abstract Background: Strong evidence suggests a correlation between pharmacodynamics (PD) index and antibiotic efficacy while dose adjustment should be considered in critic... |
PMC6202471 | core_pubmed_pmc | Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S ‐ketamine and Ticlopidine in Healthy Human Volunteers | Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S ‐ketamine and Ticlopidine in Healthy Human Volunteers Abstract Abstract Low‐dose oral S ‐ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharma... |
PMC10196432 | core_pubmed_pmc | Interplay among malnutrition, chemoprevention, and the risk of malaria in young Ugandan children: Longitudinal pharmacodynamic and growth analysis | Interplay among malnutrition, chemoprevention, and the risk of malaria in young Ugandan children: Longitudinal pharmacodynamic and growth analysis Abstract Abstract African children are at risk of malaria and malnutrition. We quantified relationships between malaria and malnutrition among young Ugandan children in a hi... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.