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PMC12536525 | core_pubmed_pmc | Clinical pharmacist-led medication review in patients with sepsis and septic shock in the intensive care unit: a non-randomized controlled study | Clinical pharmacist-led medication review in patients with sepsis and septic shock in the intensive care unit: a non-randomized controlled study Abstract Background Polypharmacy, resulting from the medications used in the management of sepsis, along with the pharmacokinetic changes induced by sepsis, can place this pat... |
PMC7749407 | core_pubmed_pmc | Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies | Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies Abstract Highlights • Angiogenesis is critical to the development and survival of solid tumors. • Vanucizumab inhibits both vascular endothelial growth factor and angiopoietin-2. • Vanucizumab exhibits anti-tumor, anti-angio... |
PMC10294342 | core_pubmed_pmc | SipNose-topiramate: a potential novel approach to binge eating management | SipNose-topiramate: a potential novel approach to binge eating management Abstract Background Binge-eating disorder) BED) is the most common eating disorder in the United-States. Daily, orally administered topiramate has shown BED treatment efficacy, with two major limitations: frequent and severe side effects and slow... |
PMC10233426 | core_pubmed_pmc | Austalide derivative from marine-derived Aspergillus sp. and evaluation of its cytotoxic and ADME/TOPKAT properties † | Austalide derivative from marine-derived Aspergillus sp. and evaluation of its cytotoxic and ADME/TOPKAT properties † Abstract In-depth chemical investigation of an ethyl acetate extract of Aspergillus sp. isolated from the soft coral Sinularia species resulted in the isolation of one new meroterpenoid, austalide Z (1)... |
PMC11682980 | core_pubmed_pmc | What are clinically significant anti-drug antibodies and why is it important to identify them | What are clinically significant anti-drug antibodies and why is it important to identify them Abstract Abstract The FDA has released new draft guidance to standardize how immunogenicity of protein therapeutics is described in product labels. A key aspect to this new guidance is that companies should describe anti-drug ... |
PMC7470105 | core_pubmed_pmc | Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients – a randomized trial | Bioavailability of oxycodone by mouth in coronary artery bypass surgery patients – a randomized trial Abstract Abstract Objective Pain after coronary artery by-pass (CAB) surgery is severe. Analgesic administration by mouth is unreliable until after gastrointestinal function has recovered. We evaluated the bioavailabil... |
PMC6263663 | core_pubmed_pmc | Population Pharmacokinetics and Exploratory Exposure‐Response Relationships of Diazepam in Children Treated for Status Epilepticus | Population Pharmacokinetics and Exploratory Exposure‐Response Relationships of Diazepam in Children Treated for Status Epilepticus Abstract Abstract Diazepam is labeled for status epilepticus (SE) in children, but there are limited data characterizing its disposition in pediatric patients. We developed a population pha... |
PMC12945714 | core_pubmed_pmc | Population PK/PD Modeling for Evaluation of Intertwining Effects of Drug and Disease on Thrombocytopenia in Acute Leukemias | Population PK/PD Modeling for Evaluation of Intertwining Effects of Drug and Disease on Thrombocytopenia in Acute Leukemias Abstract ABSTRACT In hematological malignancies, thrombocytopenia is a frequent feature of the disease. Anti‐leukemic therapies are known to impact thrombocytopenia, which is commonly selected as ... |
PMC6614128 | core_pubmed_pmc | Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies | Sensitivity of Pegfilgrastim Pharmacokinetic and Pharmacodynamic Parameters to Product Differences in Similarity Studies Abstract Abstract In this work, a previously developed pegfilgrastim (PG) population pharmacokinetic-pharmacodynamic (PKPD) model was used to evaluate potential factors of importance in the assessmen... |
PMC7586977 | core_pubmed_pmc | The Effect of Food on the Single‐Dose Bioavailability and Tolerability of the Highest Marketed Strength of Duloxetine | The Effect of Food on the Single‐Dose Bioavailability and Tolerability of the Highest Marketed Strength of Duloxetine Abstract Abstract Duloxetine is a combined serotonin and norepinephrine reuptake inhibitor indicated in adults for the treatment of major depressive disorder, diabetic peripheral neuropathic pain, and g... |
PMC10997509 | core_pubmed_pmc | Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia | Increase in peg-asparaginase clearance as a predictor for inactivation in patients with acute lymphoblastic leukemia Abstract Asparaginase is an essential component of acute lymphoblastic leukemia (ALL) therapy, yet its associated toxicities often lead to treatment discontinuation, increasing the risk of relapse. Hyper... |
PMC12171725 | core_pubmed_pmc | Phenyltriazole-based sulfonamides: novel dual-target agents against MRSA biofilms and resistant pathogens † | Phenyltriazole-based sulfonamides: novel dual-target agents against MRSA biofilms and resistant pathogens † Abstract Abstract The advent of multidrug-resistant bacteria requires the continuous development of new antimicrobial agents. A series of phenyltriazole–sulfonamide hybrid compounds (16–27) have been synthesized ... |
PMC12723143 | core_pubmed_pmc | Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study | Impact of different doses of rivaroxaban on clinical outcomes in elderly patients with non-valvular atrial fibrillation: a real-world study Abstract Abstract Introduction This study to assess the associations between different rivaroxaban doses and clinical outcomes in elderly NVAF patients in a real-world setting, and... |
PMC6484215 | core_pubmed_pmc | The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats | The effect of chronic kidney disease on CYP2B expression and activity in male Wistar rats Abstract Abstract Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function over time. CKD affects greater than 10% of the population and its incidence is on the rise due to the growing prevalence o... |
PMC6249307 | core_pubmed_pmc | Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma | Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma Abstract Abstract Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the ... |
PMC11356605 | core_pubmed_pmc | Retrospective Study of Factors Affecting the Accuracy of Predicting Vancomycin Concentrations in Patients Aged 75 Years and Above | Retrospective Study of Factors Affecting the Accuracy of Predicting Vancomycin Concentrations in Patients Aged 75 Years and Above Abstract Abstract Background and Objectives : The predicted serum concentrations of vancomycin are determined using population pharmacokinetic parameters. However, the accuracy of predicting... |
PMC9755916 | core_pubmed_pmc | Evaluation of machine learning methods for covariate data imputation in pharmacometrics | Evaluation of machine learning methods for covariate data imputation in pharmacometrics Abstract Abstract Missing data create challenges in clinical research because they lead to loss of statistical power and potentially to biased results. Missing covariate data must be handled with suitable approaches to prepare datas... |
PMC3352075 | core_pubmed_pmc | Epidemiology and antifungal resistance in invasive candidiasis | Epidemiology and antifungal resistance in invasive candidiasis Abstract The epidemiology of Candida infections has changed over the last two decades: The number of patients suffering from such infections has increased dramatically and the Candida species involved have become more numerous as Candida albicans is replace... |
PMC6441232 | core_pubmed_pmc | Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanim... | Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanim... |
PMC9290939 | core_pubmed_pmc | Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment | Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment Abstract Abstract Aims Pulmonary arterial hypertension (PAH) is char... |
PMC10905684 | core_pubmed_pmc | Unveiling the potential anti‐cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research | Unveiling the potential anti‐cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research Abstract Abstract Background Calycosin may be a potential candidate regarding chemotherapeutic agent, because already some studies against multivarious cancer have been... |
PMC12858916 | core_pubmed_pmc | Sorafenib plus selective internal radiotherapy with 90 Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial | Sorafenib plus selective internal radiotherapy with 90 Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial Abstract Abstract Introduction Selective internal radiation therapy (SIRT) and sorafenib are used for patients with liver metastases from uveal melanoma. We conducted a ... |
PMC9349143 | core_pubmed_pmc | Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review | Clinical Pharmacokinetics of Gentamicin in Various Patient Populations and Consequences for Optimal Dosing for Gram-Negative Infections: An Updated Review Abstract Gentamicin is an aminoglycoside antibiotic with a small therapeutic window that is currently used primarily as part of short-term empirical combination ther... |
PMC4618628 | core_pubmed_pmc | A window-of-opportunity biomarker study of etodolac in resectable breast cancer | A window-of-opportunity biomarker study of etodolac in resectable breast cancer Abstract Observational data show that nonsteroidal anti-inflammatory drug (NSAID) use is associated with a lower rate of breast cancer. We evaluated the effect of etodolac, an FDA-approved NSAID reported to inhibit cyclooxygenase (COX) enzy... |
PMC3575177 | core_pubmed_pmc | Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles | Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles Abstract Abstract Background and methods: A new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin A.... |
PMC9790963 | core_pubmed_pmc | First-in-human study to assess the safety, tolerability, pharmacokinetics and immunogenicity of DS002, an anti-nerve growth factor monoclonal antibody | First-in-human study to assess the safety, tolerability, pharmacokinetics and immunogenicity of DS002, an anti-nerve growth factor monoclonal antibody Abstract Abstract Purpose: To evaluate the safety, tolerability, pharmacokinetics and immunogenicity of DS002 injection, an anti-nerve growth factor (anti-NGF) monoclona... |
PMC6532211 | core_pubmed_pmc | Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration | Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration Abstract Background ONC201 is a small molecule antagonist of DRD2, a G protein-coupled receptor overexpressed in several malignancies, that has prolonged antitumor efficacy and i... |
PMC12104600 | core_pubmed_pmc | Unintentional amitriptyline overdose leading to coma and cardiac conduction impairment in an older adult: A case report | Unintentional amitriptyline overdose leading to coma and cardiac conduction impairment in an older adult: A case report Abstract Abstract Elderly patients are particularly vulnerable to look-alike/sound-alike medication errors due to physiological differences that alter medication pharmacokinetics and pharmacodynamics.... |
PMC5315734 | core_pubmed_pmc | Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade? | Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade? Abstract Abstract Allometric scaling on the basis of bodyweight raised to the power of 0.75 (AS0.75) is frequently used to scale size-related changes in plasma clearance (CL p ) from adults to children. A systematic assessment of ... |
PMC8292521 | core_pubmed_pmc | Renal 99m Tc-DMSA pharmacokinetics in pediatric patients | Renal 99m Tc-DMSA pharmacokinetics in pediatric patients Abstract Abstract Abstract 99m Tc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for 99m Tc-DMSA in children, and currently available pediatric dose estimates for 99m Tc-DMSA... |
PMC8079036 | core_pubmed_pmc | Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer | Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer Abstract Abstract Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims... |
PMC9305530 | core_pubmed_pmc | Effects of dalteparin on anti‐Xa activities cannot be predicted in critically ill COVID‐19 patients | Effects of dalteparin on anti‐Xa activities cannot be predicted in critically ill COVID‐19 patients Abstract Critically ill COVID‐19 patients are at high risk of thromboembolic events despite routine‐dosed low‐molecular‐weight heparin thromboprophylaxis. However, in recent randomized trials increased‐intensity thrombop... |
PMC8572577 | core_pubmed_pmc | Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity | Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity Abstract Abstract With the increasing epidemiology of autoimmune disease worldwide, there is an urgent need for effective drugs with low cost in clinical treatment. Triptolide, the most potent bioactive compound from tradit... |
PMC6771164 | core_pubmed_pmc | Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus | Liver‐Targeted Toll‐Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus Abstract Current therapeutics for chronic infection with hepatitis B virus (HBV) rarely induce functional cure due to the immunotolerant status of patients. Small molecule agonists ... |
PMC3554734 | core_pubmed_pmc | Comparison of Nevirapine Plasma Concentrations between Lead-In and Steady-State Periods in Chinese HIV-Infected Patients | Comparison of Nevirapine Plasma Concentrations between Lead-In and Steady-State Periods in Chinese HIV-Infected Patients Abstract Abstract Objectives To investigate the potential of nevirapine 200 mg once-daily regimen and evaluate the influence of patient characteristics on nevirapine concentrations. Methods This was ... |
PMC9142570 | core_pubmed_pmc | Population pharmacokinetics and dose optimization of intravenous levofloxacin in hospitalized adult patients | Population pharmacokinetics and dose optimization of intravenous levofloxacin in hospitalized adult patients Abstract Although levofloxacin has been used for the last 25 years, there are limited pharmacokinetic data to guide levofloxacin dosing in adult patients. This study aimed to develop a population pharmacokinetic... |
PMC12887396 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics, and pharmacodynamics of KN060, a humanized anti-FXI/FXIa dual-domain antibody, following single ascending doses in healthy Chinese subjects | Safety, tolerability, pharmacokinetics, and pharmacodynamics of KN060, a humanized anti-FXI/FXIa dual-domain antibody, following single ascending doses in healthy Chinese subjects Abstract Background KN060 is a humanized dual-domain antibody targeting coagulation factor XI (FXI) and factor XIa (FXIa) and is currently b... |
PMC8469489 | core_pubmed_pmc | Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice | Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice Abstract Abstract This study aims to investigate the effect of lactic acid bacteria (LAB) on in vitro and in vivo metabolism and the pharmacokinetics of ginsenosides in mice. When the in vitro fermentation test of RGE with LAB... |
PMC4577251 | core_pubmed_pmc | Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review | Clinically significant drug–drug interactions involving opioid analgesics used for pain treatment in patients with cancer: a systematic review Abstract Abstract Background Opioids are the most frequently used drugs to treat pain in cancer patients. In some patients, however, opioids can cause adverse effects and drug–d... |
PMC4842247 | core_pubmed_pmc | LC-MS Method for Studying the Pharmacokinetics and Bioequivalence of Clonidine Hydrochloride in Healthy Male Volunteers | LC-MS Method for Studying the Pharmacokinetics and Bioequivalence of Clonidine Hydrochloride in Healthy Male Volunteers Abstract Background: A simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in ... |
PMC12823301 | core_pubmed_pmc | Population Pharmacokinetics and Exposure‐Response Model‐Based Bayesian Extrapolation of FVC ‐Based Efficacy Endpoints From Adults to Pediatric Patients Receiving Nintedanib | Population Pharmacokinetics and Exposure‐Response Model‐Based Bayesian Extrapolation of FVC ‐Based Efficacy Endpoints From Adults to Pediatric Patients Receiving Nintedanib Abstract ABSTRACT Nintedanib reduces the rate of decline in forced vital capacity (FVC) in adult patients with idiopathic pulmonary fibrosis (IPF),... |
PMC6235005 | core_pubmed_pmc | Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans | Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans Abstract Abstract Background Paclitaxel (PTX) products currently approved by the Food and Drug Administration include Kolliphor EL-paclitaxel micelles (KoEL-paclitaxel, Taxol) and nanoparticle albu... |
PMC10634426 | core_pubmed_pmc | Effectiveness of dapagliflozin as an insulin adjunct in type 1 diabetes: a semi-mechanistic exposure-response model | Effectiveness of dapagliflozin as an insulin adjunct in type 1 diabetes: a semi-mechanistic exposure-response model Abstract Introduction: Dapagliflozin-induced improvement of glycemic control in patients with inadequately controlled type 1 diabetes (T1D) is complicated by the delicate balance between blood glucose and... |
PMC9338675 | core_pubmed_pmc | Subcutaneous administration, higher age and lower renal function are associated with erythrocyte methotrexate accumulation in Crohn’s disease: a cross-sectional study | Subcutaneous administration, higher age and lower renal function are associated with erythrocyte methotrexate accumulation in Crohn’s disease: a cross-sectional study Abstract Background Methotrexate is an immunomodulatory drug for patients with Crohn’s disease. Erythrocyte MTX-polyglutamates (MTX-PG 1-5 ) may be used ... |
PMC10390421 | core_pubmed_pmc | Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial | Pharmacokinetics, Efficacy, and Safety of a SARS-CoV-2 Antibody Treatment in Pediatric Participants: An Open-Label Addendum of a Placebo-Controlled, Randomized Phase 2/3 Trial Abstract Introduction Bamlanivimab and etesevimab (BAM + ETE) are monoclonal antibodies (mAbs) effective in reducing COVID-19-related hospitaliz... |
PMC4433689 | core_pubmed_pmc | Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s) | Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s) Abstract This study measures the curcumin concentration in rat plasma by liquid chromatography and investigates the changes in the glucose tolerance and insulin sensitivity of... |
PMC9866847 | core_pubmed_pmc | Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer | Recent Advances in Targeted Nanocarriers for the Management of Triple Negative Breast Cancer Abstract Abstract Triple-negative breast cancer (TNBC) is a life-threatening form of breast cancer which has been found to account for 15% of all the subtypes of breast cancer. Currently available treatments are significantly l... |
PMC5059376 | core_pubmed_pmc | Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle | Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle Abstract The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effecti... |
PMC11727843 | core_pubmed_pmc | Impact of DPP-4 Inhibitors in Patients with Diabetes Mellitus and Heart Failure: An In-Depth Review | Impact of DPP-4 Inhibitors in Patients with Diabetes Mellitus and Heart Failure: An In-Depth Review Abstract The increasing prevalence of both type 2 diabetes mellitus and heart failure has underscored the urgent need for optimized therapeutic strategies that address the complex interplay between these conditions. Dipe... |
PMC4573071 | core_pubmed_pmc | Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development | Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development Abstract No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied du... |
PMC12962397 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation | Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation Abstract ABSTRACT Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits... |
PMC8846319 | core_pubmed_pmc | Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis | Population Pharmacokinetic and Concentration-QTc Analysis of Delamanid in Pediatric Participants with Multidrug-Resistant Tuberculosis Abstract ABSTRACT A population pharmacokinetic analysis of delamanid and its major metabolite DM-6705 was conducted to characterize the pharmacokinetics of delamanid and DM-6705 in pedi... |
PMC9788092 | core_pubmed_pmc | c4c: Paediatric pharmacovigilance: Methodological considerations in research and development of medicines for children – A c4c expert group white paper | c4c: Paediatric pharmacovigilance: Methodological considerations in research and development of medicines for children – A c4c expert group white paper Abstract Abstract Children frequently respond differently to therapies compared to adults. Differences also exist between paediatric age groups for pharmacokinetics and... |
PMC7033535 | core_pubmed_pmc | Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers | Comparative pharmacokinetic and tolerability evaluation of two simvastatin 20 mg formulations in healthy Korean male volunteers Abstract Abstract Simvastatin is used to reduce plasma cholesterol by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is primarily used to treat hypercholesterolemia. ... |
PMC9230797 | core_pubmed_pmc | Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations | Integration of a Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Tegoprazan and Its Metabolite: Application for Predicting Food Effect and Intragastric pH Alterations Abstract A physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for tegoprazan and its major metabolite M1 was devel... |
PMC10092127 | core_pubmed_pmc | Probability of Target Attainment Analyses to Inform Ceftolozane/Tazobactam Dosing Regimens for Patients With Hospital‐Acquired or Ventilator‐Associated Bacterial Pneumonia and End‐Stage Renal Disease Receiving Intermittent Hemodialysis | Probability of Target Attainment Analyses to Inform Ceftolozane/Tazobactam Dosing Regimens for Patients With Hospital‐Acquired or Ventilator‐Associated Bacterial Pneumonia and End‐Stage Renal Disease Receiving Intermittent Hemodialysis Abstract Abstract ASPECT‐NP, a phase 3 trial of ceftolozane/tazobactam in hospital‐a... |
PMC9543781 | core_pubmed_pmc | Lack of clinically relevant differences in safety and pharmacokinetics after second‐dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis | Lack of clinically relevant differences in safety and pharmacokinetics after second‐dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis Abstract Abstract Objective Current diazepam nasal spray labeling requires waiting 4 h before administering a second do... |
PMC9929104 | core_pubmed_pmc | First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors | First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors Abstract PURPOSE OBI-999 is a novel antibody-drug conjugate comprising the Globo H–targeting antibody (OBI-888) linked to the cytotoxic payload monomethyl auristatin E. OBI-999 demonstrated excellent dos... |
PMC10309531 | core_pubmed_pmc | Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important? | Unraveling Dexamethasone-Induced Neurobehavioral and Sleep Problems in Children With ALL: Which Determinants Are Important? Abstract PURPOSE Dexamethasone, the preferred corticosteroid in most treatment protocols for pediatric acute lymphoblastic leukemia (ALL), can induce undesirable side effects. Neurobehavioral and ... |
PMC7085998 | core_pubmed_pmc | Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome | Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome Abstract Abstract Objective Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established treatment after the failure to standard of care based on steroids and vigabatrin. Converging lines of evidence... |
PMC9468563 | core_pubmed_pmc | The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects | The pharmacokinetic, safety, and tolerability profiles of eslicarbazepine acetate are comparable between Korean and White subjects Abstract Abstract Eslicarbazepine acetate (ESL) is a prodrug antiseizure medication for the treatment of focal seizures. ESL shows a well‐established pharmacokinetic (PK)‐pharmacodynamic re... |
PMC5487385 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Modeling of Tulathromycin against Pasteurella multocida in a Porcine Tissue Cage Model | Pharmacokinetic/Pharmacodynamic Modeling of Tulathromycin against Pasteurella multocida in a Porcine Tissue Cage Model Abstract Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our study was to investigate the in vitro and ex vivo activities of tula... |
PMC4697357 | core_pubmed_pmc | INTRAVITREAL CORTICOSTEROIDS IN DIABETIC MACULAR EDEMA | INTRAVITREAL CORTICOSTEROIDS IN DIABETIC MACULAR EDEMA Abstract This article reviews the safety, efficacy, and pharmacokinetics of several approved formulations of intravitreal corticosteroids for the treatment of diabetic macular edema (including triamcinolone acetonide, dexamethasone, and fluocinolone acetonide) and ... |
PMC4755689 | core_pubmed_pmc | Pharmacokinetics of daclizumab high-yield process with repeated administration of the clinical subcutaneous regimen in patients with relapsing-remitting multiple sclerosis | Pharmacokinetics of daclizumab high-yield process with repeated administration of the clinical subcutaneous regimen in patients with relapsing-remitting multiple sclerosis Abstract Abstract Background Daclizumab high-yield process (DAC HYP), a humanized immunoglobulin G1 monoclonal antibody specific for the α subunit (... |
PMC9652212 | core_pubmed_pmc | Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion | Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion Abstract Abstract Background Cytochrome P450 (CYP) 3A contributes to the metabolism of many approved drugs. CYP3A perpetrator drugs can profoundly alter t... |
PMC11476771 | core_pubmed_pmc | Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus | Impact of renal impairment on the pharmacokinetic profile of intravenous difelikefalin, a kappa opioid receptor agonist for the treatment of pruritus Abstract Abstract Background Difelikefalin is a selective kappa opioid receptor agonist that is approved for the treatment of moderate-to-severe pruritus associated with ... |
PMC12298458 | core_pubmed_pmc | Novel Micellar Formulation of Silymarin (Milk Thistle) with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial | Novel Micellar Formulation of Silymarin (Milk Thistle) with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial Abstract Background: Silymarin, a flavonoid complex, and the main bioactive component of milk thistle ( Silybum marianum ), is known for its hepatoprotective properties but suffers f... |
PMC4878769 | core_pubmed_pmc | In Vivo Pharmacokinetics/Pharmacodynamics of Cefquinome in an Experimental Mouse Model of Staphylococcus Aureus Mastitis following Intramammary Infusion | In Vivo Pharmacokinetics/Pharmacodynamics of Cefquinome in an Experimental Mouse Model of Staphylococcus Aureus Mastitis following Intramammary Infusion Abstract Abstract Staphylococcus aureus remains the major cause of morbidity of bovine mastitis worldwide leading to massive economic losses. Cefquinome is a fourth ge... |
PMC6348630 | core_pubmed_pmc | A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE) | A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE) Abstract Background Enadenotucirev is a chimeric adenovirus with demonstrated preclinical tumor-selective cytotoxicity and a short half-life. Further clinical mechanis... |
PMC7334312 | core_pubmed_pmc | A Two-Dose Oritavancin Regimen Using Pharmacokinetic Estimation Analysis | A Two-Dose Oritavancin Regimen Using Pharmacokinetic Estimation Analysis Abstract Abstract Background Antibiotics for the treatment of complicated, multidrug-resistant Gram-positive infections are limited, especially when prolonged treatment is necessary. Oritavancin is approved for the treatment of serious skin infect... |
PMC12433887 | core_pubmed_pmc | Evaluation of anti-liver cancer activity and anticancer mechanism of one novel small molecule compound (THY-10A62) targeting FAK pathway | Evaluation of anti-liver cancer activity and anticancer mechanism of one novel small molecule compound (THY-10A62) targeting FAK pathway Abstract Abstract Introduction Focal adhesion kinase (FAK) is a promising therapeutic target, and its aberrant overexpression has been implicated in the growth and metastasis of multi... |
PMC3875564 | core_pubmed_pmc | Quantitative Analysis of Microbicide Concentrations in Fluids, Gels and Tissues Using Confocal Raman Spectroscopy | Quantitative Analysis of Microbicide Concentrations in Fluids, Gels and Tissues Using Confocal Raman Spectroscopy Abstract Abstract Topical vaginal anti-HIV microbicides are an important focus in female-based strategies to prevent the sexual transmission of HIV. Understanding microbicide pharmacokinetics is essential t... |
PMC4777251 | core_pubmed_pmc | Bioequivalence of saxagliptin/dapagliflozin fixed‐dose combination tablets compared with coadministration of the individual tablets to healthy subjects | Bioequivalence of saxagliptin/dapagliflozin fixed‐dose combination tablets compared with coadministration of the individual tablets to healthy subjects Abstract Abstract Saxagliptin and dapagliflozin are individually indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes... |
PMC4076806 | core_pubmed_pmc | A Bayesian Perspective on Estimation of Variability and Uncertainty in Mechanism-Based Models | A Bayesian Perspective on Estimation of Variability and Uncertainty in Mechanism-Based Models Abstract Abstract Mechanism-based pharmacokinetic/pharmacodynamic models have a fundamental basis in biology and pharmacology and, thus, are useful for hypothesis generation and extrapolation beyond the conditions of the origi... |
PMC12596893 | core_pubmed_pmc | Pharmacogenetics in Tuberculosis-HIV Coinfected Populations: A Systematic Review of Genetic Variants Influencing Antiretroviral and Anti-Tuberculosis Drug Response | Pharmacogenetics in Tuberculosis-HIV Coinfected Populations: A Systematic Review of Genetic Variants Influencing Antiretroviral and Anti-Tuberculosis Drug Response Abstract Abstract Pharmacogenetics is a concept designed to tailor medication based on genetic profile to improve efficacy and reduce adverse effects. This ... |
PMC10921286 | core_pubmed_pmc | Keep in mind sex differences when prescribing psychotropic drugs | Keep in mind sex differences when prescribing psychotropic drugs Abstract Abstract Women represent the majority of patients with psychiatric diagnoses and also the largest users of psychotropic drugs. There are inevitable differences in efficacy, side effects and long-term treatment response between men and women. Psyc... |
PMC11786465 | core_pubmed_pmc | How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies | How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies Abstract Background The euglycemic clamp test stands as the best method for assessing the pharmacokinetic and pharmacodynamic properties of long-acting insulin. However, despite its widespread use, there remains a notable absenc... |
PMC6076366 | core_pubmed_pmc | Intranasal rifampicin for Alzheimer's disease prevention | Intranasal rifampicin for Alzheimer's disease prevention Abstract Abstract Introduction Oral rifampicin has been shown to significantly reduce amyloid β (Aβ) and tau pathologies in mice. However, it shows occasional adverse effects such as liver injury in humans, making its use difficult for a long period. Methods To e... |
PMC9857140 | core_pubmed_pmc | Hemodialysis as emergency treatment of a severe baclofen intoxication in a 3 kg dog | Hemodialysis as emergency treatment of a severe baclofen intoxication in a 3 kg dog Abstract Abstract Objective To describe the clinical efficacy and drug removal kinetics of hemodialysis (HD) as emergency treatment in a small size dog with severe baclofen intoxication. Case description A 2‐year‐old dog was presented i... |
PMC6794948 | core_pubmed_pmc | CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice | CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice Abstract Abstract Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in associat... |
PMC5697013 | core_pubmed_pmc | Development and Qualification of Physiologically Based Pharmacokinetic Models for Drugs With Atypical Distribution Behavior: A Desipramine Case Study | Development and Qualification of Physiologically Based Pharmacokinetic Models for Drugs With Atypical Distribution Behavior: A Desipramine Case Study Abstract Abstract Desipramine is a secondary tricyclic amine, which is primarily metabolized by cytochrome 2D6. It shows a high volume of distribution (Vss) (10–50 L/kg) ... |
PMC12433207 | core_pubmed_pmc | Role of Radioiodine in Cancer Therapy: A Review of the Design and Challenges in Selecting Radioligands from Natural Sources | Role of Radioiodine in Cancer Therapy: A Review of the Design and Challenges in Selecting Radioligands from Natural Sources Abstract Abstract The use of radioactive isotopes in cancer treatment has marked a pivotal shift in modern medicine, where precise diagnosis and targeted therapy now blend to offer patients more e... |
PMC7572575 | core_pubmed_pmc | The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models | The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models Abstract The complexity of integrating microbiota into clinical pharmacology, environmental toxicology, and opioid studies arises from bidirectional and mu... |
PMC4786809 | core_pubmed_pmc | Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC/MS-MS and its application to a short-term pharmacokinetic study | Determination of cyanidin 3-glucoside in rat brain, liver and kidneys by UPLC/MS-MS and its application to a short-term pharmacokinetic study Abstract Anthocyanins exert neuroprotection in various in vitro and in vivo experimental models. However, no details regarding their brain-related pharmacokinetics are so far ava... |
PMC5124695 | core_pubmed_pmc | Clinical Evaluation of Humira ® Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics | Clinical Evaluation of Humira ® Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics Abstract Abstract ONS-3010 is being developed by Oncobiologics Inc. (Cranbury, NJ, USA) as a biosimilar of Humira ® . This randomized, double blind, single-center phase I study (EudraCT registration... |
PMC12072017 | core_pubmed_pmc | Absorption Patterns of Fucoidan Oligosaccharides from Kjellmaniella crassifolia in the Caco-2 Monolayer Cell Model and Their Pharmacokinetics in Mice | Absorption Patterns of Fucoidan Oligosaccharides from Kjellmaniella crassifolia in the Caco-2 Monolayer Cell Model and Their Pharmacokinetics in Mice Abstract Oligosaccharides possess characteristics such as low molecular weight, good solubility, and high bioavailability, which make them better absorbed than fucoidan. ... |
PMC11324966 | core_pubmed_pmc | Mini review advantages and limitations of lytic phages compared with chemical antibiotics to combat bacterial infections | Mini review advantages and limitations of lytic phages compared with chemical antibiotics to combat bacterial infections Abstract The overuse of antibiotics has caused the emergence of antibiotic-resistant strains, such as multidrug-resistant, extensively drug-resistant, and pandrug-resistant bacteria. The treatment of... |
PMC11475554 | core_pubmed_pmc | Gender-Specific Prognostic Impact of Treosulfan Levels in High-Dose Chemotherapy for Multiple Myeloma | Gender-Specific Prognostic Impact of Treosulfan Levels in High-Dose Chemotherapy for Multiple Myeloma Abstract Simple Summary High-dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM). This study examines gender-specific differences in response to t... |
PMC3356170 | core_pubmed_pmc | Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS | Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS Abstract A novel formulation containing polyvinylpyrrolidone (PVP) K 30 -coated norcantharidin (NCTD) chitosan nanoparticles (PVP–NCTD–NPs) was prepar... |
PMC8246815 | core_pubmed_pmc | Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect | Pharmacokinetics of Deutetrabenazine and Tetrabenazine: Dose Proportionality and Food Effect Abstract Abstract Deutetrabenazine (Austedo, Teva), an approved treatment of chorea in Huntington's disease and tardive dyskinesia in adult patients, is a rationally designed deuterated form of tetrabenazine. Two studies assess... |
PMC7429772 | core_pubmed_pmc | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone | Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone Abstract Background The prevalence and therapeutic effects of the use of herbal remedies for chronic liver diseases make the combined administration of herbal products with conventio... |
PMC11076592 | core_pubmed_pmc | Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria | Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria Abstract Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic ... |
PMC7869082 | core_pubmed_pmc | Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea | Phase I studies of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: a pooled analysis of two phase I studies conducted in Japan and Korea Abstract Abstract Objective Two phase I studies of darinaparsin including Japanese and Korean patients with relapsed/refractory peripheral T-cell lymp... |
PMC6092551 | core_pubmed_pmc | Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models | Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models Abstract Abstract Leber congenital amaurosis type 10 (LCA10) is a severe inherited retinal dystrophy associated with mutations in CEP290 . The deep intronic c.2991+1655A>G mutation in CEP290 is the most commo... |
PMC6858417 | core_pubmed_pmc | Pharmacokinetics of Azithromycin, Levofloxacin, and Ofloxacin in Rabbit Extraocular Tissues After Ophthalmic Administration | Pharmacokinetics of Azithromycin, Levofloxacin, and Ofloxacin in Rabbit Extraocular Tissues After Ophthalmic Administration Abstract Introduction Azithromycin demonstrates high tissue distribution and prolonged elimination half-life. In this study, we monitored the pharmacokinetics of a single ophthalmic administration... |
PMC9662918 | core_pubmed_pmc | Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors | Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors Abstract Abstract Purpose: Chemotherapy resistance remains a major problem in many solid tumors, including breast, ovarian, and pancreatic cancer. Glucocortic... |
PMC11657593 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 versus reference denosumab in healthy males: A randomized phase I study | Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of HLX14 versus reference denosumab in healthy males: A randomized phase I study Abstract Abstract Denosumab is a human IgG2 monoclonal antibody against receptor activator of nuclear factor kappa‐B ligand (RANKL) for the treatment of osteoporosis and bone l... |
PMC9972017 | core_pubmed_pmc | A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation | A phase I trial of metformin in combination with vincristine, irinotecan, and temozolomide in children with relapsed or refractory solid and central nervous system tumors: A report from the national pediatric cancer foundation Abstract Abstract Background Patients with relapsed and refractory solid and central nervous ... |
PMC7055956 | core_pubmed_pmc | Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials | Mathematical modeling to reveal breakthrough mechanisms in the HIV Antibody Mediated Prevention (AMP) trials Abstract Abstract The ongoing Antibody Mediated Prevention (AMP) trials will uncover whether passive infusion of the broadly neutralizing antibody (bNAb) VRC01 can protect against HIV acquisition. Previous stati... |
PMC8643150 | core_pubmed_pmc | Is the Fixed Periodic Treatment Effective for the Tumor System without Complete Information? | Is the Fixed Periodic Treatment Effective for the Tumor System without Complete Information? Abstract Objective The treatment plans designed with the guidance of the mathematical model and adaptive strategy can trap tumor subpopulations in a periodic and controllable loop. But this process requires detailed information... |
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