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PMC11616965 | core_pubmed_pmc | Clinical pearls for the management of duloxetine patients with medical comorbidities | Clinical pearls for the management of duloxetine patients with medical comorbidities Abstract The effective use of duloxetine can be complicated by acute kidney injury, acute and/or chronic hepatic dysfunction, dysphagia, enteral nutrition, and common pharmacokinetic interactions. This article aimed to review the pharm... |
PMC9068598 | core_pubmed_pmc | Immunobiology of tubercle bacilli and prospects of immunomodulatory drugs to tackle tuberculosis (TB) and other non-tubercular mycobacterial infections | Immunobiology of tubercle bacilli and prospects of immunomodulatory drugs to tackle tuberculosis (TB) and other non-tubercular mycobacterial infections Abstract The COVID-19 pandemic has set back progress made on antimicrobial resistance (AMR). Without urgent re-focus, we risk slowing down drug discovery and providing ... |
PMC12390456 | core_pubmed_pmc | Comparison of Intravenous and Oral Meloxicam Pharmacokinetics in Female and Male Saanen Goats | Comparison of Intravenous and Oral Meloxicam Pharmacokinetics in Female and Male Saanen Goats Abstract Simple Summary Meloxicam is a medication commonly used in animals to reduce pain and inflammation, helping them recover more comfortably after illness or surgery. However, the way this medication is processed in the b... |
PMC4810081 | core_pubmed_pmc | Venetoclax (ABT-199) Might Act as a Perpetrator in Pharmacokinetic Drug–Drug Interactions | Venetoclax (ABT-199) Might Act as a Perpetrator in Pharmacokinetic Drug–Drug Interactions Abstract Abstract Venetoclax (ABT-199) represents a specific B-cell lymphoma 2 (Bcl-2) inhibitor that is currently under development for the treatment of lymphoid malignancies. So far, there is no published information on its inte... |
PMC12294483 | core_pubmed_pmc | Laser-Induced Dimeric Photoproducts of Chlorpromazine: LC-MS Identification and Molecular Docking Evidence of Enhanced Anticancer Potential | Laser-Induced Dimeric Photoproducts of Chlorpromazine: LC-MS Identification and Molecular Docking Evidence of Enhanced Anticancer Potential Abstract Breast cancer treatments, such as chemotherapy, radiation, and surgery, often face significant limitations, highlighting the need for more effective and targeted therapies... |
PMC7520415 | core_pubmed_pmc | Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both? | Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both? Abstract Abstract The inclusion of covariates in population models during drug development is a key step to understanding drug variability and support dosage regimen proposal, but high ... |
PMC7359987 | core_pubmed_pmc | The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics | The Roles of Common Variation and Somatic Mutation in Cancer Pharmacogenomics Abstract Abstract Cancer pharmacogenomics is the science concerned with understanding genetic alterations and its effects on the pharmacokinetics and pharmacodynamics of anti-cancer drugs, with the aim to provide cancer patients with the prec... |
PMC6251219 | core_pubmed_pmc | AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial | AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial Abstract Background Cryptococcal meningitis (CM) is a major cause of mortality in HIV programmes in Africa ... |
PMC4258503 | core_pubmed_pmc | Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms | Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms Abstract The present study aimed to examine the enantiomer-selective pharmacokinetics (PK), relative bioavailability (F rel ), and sex effects of various oral dosage forms of racemic alpha-lipoic acid ... |
PMC9248796 | core_pubmed_pmc | A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2) | A trial design to maximize knowledge of the effects of rodatristat ethyl in the treatment of pulmonary arterial hypertension (ELEVATE 2) Abstract Abstract Serotonin plays a key role in the development and maintenance of the pathobiology associated with pulmonary arterial hypertension (PAH). Platelet‐driven and locally ... |
PMC11469894 | core_pubmed_pmc | Vesicle-based formulations for pain treatment: a narrative review | Vesicle-based formulations for pain treatment: a narrative review Abstract Vesicle-based drug delivery offers promising solutions by enhancing efficacy, reducing toxicity, enabling targeted pain relief, and overcoming the limitations of current treatments. Abstract Pain, a complex and debilitating condition, necessitat... |
PMC4429480 | core_pubmed_pmc | Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study | Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97–78 in rat plasma using the HPLC–ESI-MS/MS method: application to drug interaction study Abstract Background Lumefantrine is the mainstay of anti-malarial combination therapy in most endemic countries presently. Howe... |
PMC3506523 | core_pubmed_pmc | DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic | DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic Abstract Background The clinical effects of varying pharmacokinetic exposures of antibiotics (antibacterials and antif... |
PMC9656453 | core_pubmed_pmc | A Rapid and Sensitive LC−MS/MS Method for the Quantitation of Physalin A with Special Consideration to Chemical Stability in Rat Plasma: Application to a Pharmacokinetic Study | A Rapid and Sensitive LC−MS/MS Method for the Quantitation of Physalin A with Special Consideration to Chemical Stability in Rat Plasma: Application to a Pharmacokinetic Study Abstract Abstract Physalin A is a promising natural product with excellent anti-inflammatory and anti-tumor activities. However, the pharmacokin... |
PMC8506700 | core_pubmed_pmc | Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease undergoing hematopoietic stem cell transplantation | Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease undergoing hematopoietic stem cell transplantation Abstract Background This study aimed to explore the effects of voriconazole on population pharmacokinetics and optim... |
PMC12697364 | core_pubmed_pmc | Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms | Regulation of Renal Transporters by Pro-inflammatory Cytokines in Human Proximal Tubular Epithelial Cells: Identification of the Perpetrator and Mechanisms Abstract Abstract Introduction Infection and inflammation elevate circulating pro-inflammatory cytokines that can affect renal drug clearance. Accordingly, we sough... |
PMC6661551 | core_pubmed_pmc | Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC) | Repetitive electrostatic pressurised intraperitoneal aerosol chemotherapy (ePIPAC) with oxaliplatin as a palliative monotherapy for isolated unresectable colorectal peritoneal metastases: protocol of a Dutch, multicentre, open-label, single-arm, phase II study (CRC-PIPAC) Abstract Abstract Introduction Repetitive elect... |
PMC10304707 | core_pubmed_pmc | Gut Microbiota-Mediated Pharmacokinetic Drug–Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans | Gut Microbiota-Mediated Pharmacokinetic Drug–Drug Interactions between Mycophenolic Acid and Trimethoprim-Sulfamethoxazole in Humans Abstract Abstract Mycophenolic acid (MPA) and trimethoprim-sulfamethoxazole (TMP-SMX) are commonly prescribed together in certain groups of patients, including solid organ transplant reci... |
PMC4335020 | core_pubmed_pmc | Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women | Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women Abstract The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol an... |
PMC12524999 | core_pubmed_pmc | Pharmacokinetic Alterations in Patients with Chronic Heart Failure: A Systematic Review | Pharmacokinetic Alterations in Patients with Chronic Heart Failure: A Systematic Review Abstract (1) Chronic heart failure (CHF) is a typical component of the polymorbid profile of an elderly patient. The aim of this systematic review was to search for data from pharmacokinetic (PK) studies of any drugs in patients wit... |
PMC7522823 | core_pubmed_pmc | Vancomycin Dosing Practices among Critical Care Pharmacists: A Survey of Society of Critical Care Medicine Pharmacists | Vancomycin Dosing Practices among Critical Care Pharmacists: A Survey of Society of Critical Care Medicine Pharmacists Abstract Abstract Introduction: Critically ill patients and their pharmacokinetics present complexities often not considered by consensus guidelines from the American Society of Health-System Pharmacis... |
PMC10674389 | core_pubmed_pmc | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy | A Literature Review of Changes in Phase II Drug-Metabolizing Enzyme and Drug Transporter Expression during Pregnancy Abstract The purpose of this literature review is to comprehensively summarize changes in the expression of phase II drug-metabolizing enzymes and drug transporters in both the pregnant woman and the pla... |
PMC12659884 | core_pubmed_pmc | Comparative evaluation of the effect of various transdermal patches and oral nonsteroidal anti-inflammatory drugs on postoperative endodontic pain and quality of life – A placebo-controlled randomized clinical trial | Comparative evaluation of the effect of various transdermal patches and oral nonsteroidal anti-inflammatory drugs on postoperative endodontic pain and quality of life – A placebo-controlled randomized clinical trial Abstract Aim: To evaluate the efficacy of preemptive ketoprofen transdermal patch (KTP) administration a... |
PMC6038347 | core_pubmed_pmc | Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL) | Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL) Abstract Abstract Background A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy ... |
PMC12357786 | core_pubmed_pmc | Population pharmacokinetic and exposure-response study of a novel anti-tuberculosis drug to inform its dosage design in phase III clinical trial | Population pharmacokinetic and exposure-response study of a novel anti-tuberculosis drug to inform its dosage design in phase III clinical trial Abstract Although bedaquiline (BDQ) received conditional approval for multi-drug resistance tuberculosis (MDR-TB), a black box warning was added due to QT prolongation risk. W... |
PMC12867113 | core_pubmed_pmc | Neuroprotective effects of kojic acid and nano-kojic acid in experimental brain ischemia induced by bilateral common carotid artery occlusion | Neuroprotective effects of kojic acid and nano-kojic acid in experimental brain ischemia induced by bilateral common carotid artery occlusion Abstract Objective(s): Brain ischemia remains a leading cause of death and neurological disability worldwide, with current treatments limited by narrow therapeutic windows and in... |
PMC7517694 | core_pubmed_pmc | Hydroxychloroquine levels in patients with systemic lupus erythematosus: whole blood is preferable but serum levels also detect non-adherence | Hydroxychloroquine levels in patients with systemic lupus erythematosus: whole blood is preferable but serum levels also detect non-adherence Abstract Abstract Background Hydroxychloroquine (HCQ) levels can be measured in both serum and whole blood. No cut-off point for non-adherence has been established in serum nor h... |
PMC3782471 | core_pubmed_pmc | In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra | In Silico and In Vivo Anti-Malarial Studies of 18β Glycyrrhetinic Acid from Glycyrrhiza glabra Abstract Abstract Malaria is one of the most prevailing fatal diseases causing between 1.2 and 2.7 million deaths all over the world each year. Further, development of resistance against the frontline anti-malarial drugs has ... |
PMC3697038 | core_pubmed_pmc | An Approach for Identifiability of Population Pharmacokinetic–Pharmacodynamic Models | An Approach for Identifiability of Population Pharmacokinetic–Pharmacodynamic Models Abstract Abstract Mathematical models are routinely used in clinical pharmacology to study the pharmacokinetic and pharmacodynamic properties of a drug in the body. Identifiability of these models is an important requirement for the su... |
PMC3598979 | core_pubmed_pmc | Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration | Pharmacokinetic study on pradofloxacin in the dog – Comparison of serum analysis, ultrafiltration and tissue sampling after oral administration Abstract Background Pradofloxacin, a newly developed 8-cyano-fluoroquinolone, show enhanced activity against Gram-positive organisms and anaerobes to treat canine and feline ba... |
PMC7699451 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects | Pharmacokinetic/Pharmacodynamic Interactions Between Evogliptin and Glimepiride in Healthy Male Subjects Abstract Purpose Evogliptin, a dipeptidyl peptidase-4 inhibitor, and glimepiride, a sulfonylurea, are used to treat type 2 diabetes mellitus. In this study, we aimed to evaluate the pharmacokinetic (PK) and pharmaco... |
PMC11657253 | core_pubmed_pmc | A new strategy for monitoring of direct oral anticoagulants in patients with cyanotic and complex congenital heart disease | A new strategy for monitoring of direct oral anticoagulants in patients with cyanotic and complex congenital heart disease Abstract Background Patients with congenital heart disease (CHD) often require an oral anticoagulation. Vitamin K antagonists (VKA) are the standard treatment, however, an increased hematocrit in p... |
PMC4435065 | core_pubmed_pmc | A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics? | A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics? Abstract Abstract Drug bioavailability may vary greatly amongst individuals, affecting both efficacy and toxicity: in humans, genetic variations account for a relevant proportion of such variability. In the last decade the use... |
PMC5896440 | core_pubmed_pmc | Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System | Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System Abstract Abstract Introduction Novel nicotine delivery systems represent an evolving part of the tobacco harm reduction strategy. The pharmacokinetic (PK) profile of nicotine delivered by P3L, a pulmonary ni... |
PMC3324841 | core_pubmed_pmc | Safety of recombinant human platelet-derived growth factor-BB in Augment ® Bone Graft | Safety of recombinant human platelet-derived growth factor-BB in Augment ® Bone Graft Abstract This article discusses nonclinical and clinical data regarding the safety of recombinant human platelet-derived growth factor-BB as a component of the Augment ® Bone Graft ( Augment ). Augment is a bone graft substitute inten... |
PMC12888888 | core_pubmed_pmc | Pharmacokinetics/pharmacodynamics of ceftazidime-avibactam in critically ill adult patients receiving continuous renal replacement therapy | Pharmacokinetics/pharmacodynamics of ceftazidime-avibactam in critically ill adult patients receiving continuous renal replacement therapy Abstract ABSTRACT Ceftazidime-avibactam (CAZ-AVI), a novel antibiotic, is effective in treating infections caused by carbapenem-resistant Gram-negative bacteria. However, in patient... |
PMC9274542 | core_pubmed_pmc | TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer | TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer Abstract Background Recombinant interleukin-2 (IL-2, aldesleukin) is an approved cancer immunotherapy but... |
PMC9345835 | core_pubmed_pmc | Translational Modeling Predicts Efficacious Therapeutic Dosing Range of Teclistamab for Multiple Myeloma | Translational Modeling Predicts Efficacious Therapeutic Dosing Range of Teclistamab for Multiple Myeloma Abstract Background Teclistamab (JNJ-64007957), a B-cell maturation antigen × CD3 bispecific antibody, displayed potent T-cell–mediated cytotoxicity of multiple myeloma cells in preclinical studies. Objective A firs... |
PMC9866963 | core_pubmed_pmc | Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies | Partitioning of Persistent Organic Pollutants between Adipose Tissue and Serum in Human Studies Abstract Blood is the most widely used matrix for biomonitoring of persistent organic pollutants (POPs). It is assumed that POPs are homogenously distributed within body lipids at steady state; however, the variability under... |
PMC10218858 | core_pubmed_pmc | Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy? | Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy? Abstract Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a definin... |
PMC6742937 | core_pubmed_pmc | Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data | Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data Abstract Prediction of human pharmacokinetics (PK) based on preclinical information for antibody–drug conjugates (ADCs) provide important insight into first‐in‐human (FIH) study design. This retrospective analysis was conducted to id... |
PMC5475299 | core_pubmed_pmc | In vitro inhibition of lipid accumulation induced by oleic acid and in vivo pharmacokinetics of chitosan microspheres (CTMS) and chitosan-capsaicin microspheres (CCMS) | In vitro inhibition of lipid accumulation induced by oleic acid and in vivo pharmacokinetics of chitosan microspheres (CTMS) and chitosan-capsaicin microspheres (CCMS) Abstract ABSTRACT Chitosan and capsaicin are compounds extracted from natural products and have been indicated to lower body weight and prevent fatty li... |
PMC6032820 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective | Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective Abstract This work provides a perspective on the qualification and verification of physiologically based pharmacokinetic (PBPK) platforms/models intended for regulatory submission base... |
PMC12046392 | core_pubmed_pmc | Population pharmacokinetics and exposure–response relationship of the antituberculosis drug BTZ-043 | Population pharmacokinetics and exposure–response relationship of the antituberculosis drug BTZ-043 Abstract Abstract Introduction BTZ-043 is a first-in-class benzothiazinone for the treatment of TB with demonstrated early bactericidal activity. BTZ-043 is metabolized into two major metabolites: M1 and M2. The aim of t... |
PMC11941075 | core_pubmed_pmc | Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer | Molecular Docking and Pharmacological In Silico Evaluation of Camptothecin and Related Ligands as Promising HER2-Targeted Therapies for Breast Cancer Abstract Abstract Breast cancer is one of the leading causes of cancer-related mortality in women worldwide, highlighting the importance of effective therapies. This stud... |
PMC8278299 | core_pubmed_pmc | Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data | Optimizing Oral Targeted Anticancer Therapies Study for Patients With Solid Cancer: Protocol for a Randomized Controlled Medication Adherence Program Along With Systematic Collection and Modeling of Pharmacokinetic and Pharmacodynamic Data Abstract Abstract Background The strengthening or substitution of intravenous cy... |
PMC6373187 | core_pubmed_pmc | Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics | Oral administration of irinotecan in patients with solid tumors: an open-label, phase I, dose escalating study evaluating safety, tolerability and pharmacokinetics Abstract Abstract Background Oral drug formulations have several advantages compared to intravenous formulation. Apart from patient convenience and favorabl... |
PMC7179958 | core_pubmed_pmc | Prediction of Clinical Transporter‐Mediated Drug–Drug Interactions via Comeasurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models | Prediction of Clinical Transporter‐Mediated Drug–Drug Interactions via Comeasurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models Abstract Abstract A structurally identifiable micro‐rate constant mechanistic model was used to describe the interaction between pitavastatin and eltrombopag, with improved goo... |
PMC8563584 | core_pubmed_pmc | Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation | Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation Abstract Abstract Many factors have been described to contribute to voriconazole (VCZ) interpatient variability in plasma conc... |
PMC9961155 | core_pubmed_pmc | Ventilator-Associated Pneumonia in COVID-19 Patients Admitted in Intensive Care Units: Relapse, Therapeutic Failure and Attributable Mortality—A Multicentric Observational Study from the OutcomeRea Network | Ventilator-Associated Pneumonia in COVID-19 Patients Admitted in Intensive Care Units: Relapse, Therapeutic Failure and Attributable Mortality—A Multicentric Observational Study from the OutcomeRea Network Abstract Abstract Introduction: Ventilator-associated pneumonia (VAP) incidence is high among critically ill COVID... |
PMC11078291 | core_pubmed_pmc | Effect of Bedaquiline and Delamanid Pharmacokinetics on Sputum Culture Conversion and Adverse Events in Drug-Resistant Tuberculosis | Effect of Bedaquiline and Delamanid Pharmacokinetics on Sputum Culture Conversion and Adverse Events in Drug-Resistant Tuberculosis Abstract Abstract Background: Pharmacokinetic studies of bedaquiline and delamanid in patients with pre-extensively drug-resistant tuberculosis (pre-XDR TB) will help in the optimization o... |
PMC6124791 | core_pubmed_pmc | Clinical utility of fulvestrant in the treatment of breast cancer: a report on the emerging clinical evidence | Clinical utility of fulvestrant in the treatment of breast cancer: a report on the emerging clinical evidence Abstract Abstract Fulvestrant is the first selective estrogen receptor (ER) downregulator available in clinical practice. It is a pure antiestrogen with no agonistic effects, leading to degradation of ER alpha,... |
PMC4231999 | core_pubmed_pmc | Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily | Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily Abstract Objectives Antiretroviral therapy during pregnancy is recommended to reduce the risk of mother-to-child transmission of HIV and for maternal care man... |
PMC8868358 | core_pubmed_pmc | The Role of Colistin in the Era of New β-Lactam/β-Lactamase Inhibitor Combinations | The Role of Colistin in the Era of New β-Lactam/β-Lactamase Inhibitor Combinations Abstract With the current crisis related to the emergence of carbapenem-resistant Gram-negative bacteria (CR-GNB), classical treatment approaches with so-called “old-fashion antibiotics” are generally unsatisfactory. Newly approved β-lac... |
PMC4324411 | core_pubmed_pmc | A Bayesian decision support tool for efficient dose individualization of warfarin in adults and children | A Bayesian decision support tool for efficient dose individualization of warfarin in adults and children Abstract Background Warfarin is the most widely prescribed anticoagulant for the prevention and treatment of thromboembolic events. Although highly effective, the use of warfarin is limited by a narrow therapeutic r... |
PMC12801910 | core_pubmed_pmc | Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial | Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Abstract Abstract Background KL130008 is a selective Janus kinase 1/2 inhibitor with encouraging preclinical efficacy. Phase I trials in healthy volunteers and patient... |
PMC10192552 | core_pubmed_pmc | P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses | P-glycoprotein efflux transporter: a key to pharmacokinetic modeling for methadone clearance in fetuses Modeling In vivo animal models As a synthetic opioid agonist, methadone is mainly eliminated via hepatic metabolism by CYP 2B6, and partly by CYP 3A4 ( Garrido and Trocóniz, 1999 ; Kharasch, 2017 ). Its concentration... |
PMC11179705 | core_pubmed_pmc | Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2 | Translational kinetic‐pharmacodynamics of mRNA‐6231, an investigational mRNA therapeutic encoding mutein interleukin‐2 Abstract Abstract Regulatory T cells (T regs ) are essential for maintaining immune homeostasis by serving as negative regulators of adaptive immune system effector cell responses. Reduced production o... |
PMC8309133 | core_pubmed_pmc | Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout ( Oncorhynchus mykiss ) Broodstock | Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout ( Oncorhynchus mykiss ) Broodstock Abstract Abstract The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout ( Oncorhynchus mykiss ) broodstock at temperatu... |
PMC12639577 | core_pubmed_pmc | Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function | Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function Abstract Summary Background Antibody drugs blocking the complement classical pathway (CP) often require frequent intravenous administration to overcome the high abundance or rapid turnover of complement prot... |
PMC9492280 | core_pubmed_pmc | Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges | Stem Cell Therapies for Chronic Liver Diseases: Progress and Challenges Abstract Abstract Chronic liver diseases have become a significant health issue worldwide and urgently require the development of novel therapeutic approaches, in addition to liver transplantation. Recent clinical and preclinical studies have shown... |
PMC10720486 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of ibrexafungerp in healthy Chinese subjects: a randomized, double-blind, placebo-controlled phase 1 trial | Safety, tolerability, and pharmacokinetics of ibrexafungerp in healthy Chinese subjects: a randomized, double-blind, placebo-controlled phase 1 trial Abstract ABSTRACT Ibrexafungerp (code name in China: HS-10366) is a first-in-class and orally active triterpenoid antifungal agent with broad antifungal activity against ... |
PMC10082376 | core_pubmed_pmc | Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model | Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model Abstract Introduction Estimation of accurate time-integrated activity coefficients (TIACs) and radiation absorbed doses (ADs) is desirable for treatment planning in peptide-receptor radionuclide therapy (PRRT). This study aime... |
PMC5574006 | core_pubmed_pmc | Population Pharmacokinetics of Brentuximab Vedotin in Patients With CD30‐Expressing Hematologic Malignancies | Population Pharmacokinetics of Brentuximab Vedotin in Patients With CD30‐Expressing Hematologic Malignancies Abstract Abstract Brentuximab vedotin, a CD30‐directed antibody‐drug conjugate (ADC), is approved for treating certain patients with CD30‐expressing hematologic malignancies. Its primary mechanism of action is t... |
PMC10582659 | core_pubmed_pmc | An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat | An innovative phase I study in healthy subjects to determine the mass balance, elimination, metabolism, and absolute bioavailability of mitapivat Abstract Abstract Mitapivat, a first‐in‐class, oral, small‐molecule, allosteric activator of the red blood cell‐specific form of pyruvate kinase (PKR), was approved for the t... |
PMC12638810 | core_pubmed_pmc | Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology | Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology Abstract Abstract Artificial intelligence (AI) is opening new frontiers in the development of antibody-drug conjugates (ADCs), offering unprecedented opportunities for precision ther... |
PMC7439710 | core_pubmed_pmc | Randomized double-blind clinical trial comparing safety and efficacy of the biosimilar BCD-022 with reference trastuzumab | Randomized double-blind clinical trial comparing safety and efficacy of the biosimilar BCD-022 with reference trastuzumab Abstract Abstract Background BCD-022 is a trastuzumab biosimilar which was shown to be equivalent to reference trastuzumab in a wide panel of physicochemical studies as well as preclinical studies i... |
PMC12062087 | core_pubmed_pmc | Therapeutic peptides: chemical strategies fortify peptides for enhanced disease treatment efficacy | Therapeutic peptides: chemical strategies fortify peptides for enhanced disease treatment efficacy Abstract Therapeutic peptides, as a unique form of medication composed of orderly arranged sequences of amino acids, are valued for their high affinity, specificity, low immunogenicity, and economical production costs. Cu... |
PMC12727275 | core_pubmed_pmc | Phase Ia/b Multicenter Study of BPM31510IV Targeting Mitochondrial Metabolism/Warburg Effect as Monotherapy and Combination Chemotherapy in Solid Tumor Patients | Phase Ia/b Multicenter Study of BPM31510IV Targeting Mitochondrial Metabolism/Warburg Effect as Monotherapy and Combination Chemotherapy in Solid Tumor Patients Abstract Abstract Purpose: BPM31510IV, a highly bioavailable intravenously administered coenzyme Q 10 (CoQ 10 ) formulation, was evaluated in a phase Ia/Ib stu... |
PMC10658303 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice | Pharmacokinetic and pharmacodynamic drug-drug interaction of Nomilin with atorvastatin in hyperlipidemic mice Abstract Abstract Atorvastatin (Atv) is widely used to lower cholesterol levels and treat hyperlipidemia in clinical application. Nomilin (Nom) is a kind of limonoids, which is found and isolated from the citru... |
PMC11780246 | core_pubmed_pmc | Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses | Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses Abstract Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression ... |
PMC12510943 | core_pubmed_pmc | Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment | Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment Abstract Abstract Today, a variety of multivalent antibody formats can be engineered, offering significant flexibility for therapeutic and diagnostic approaches. While unmodified antibodies have evolved to be structural... |
PMC10477696 | core_pubmed_pmc | Evaluation of polymyxin B AUC/MIC ratio for dose optimization in patients with carbapenem-resistant Klebsiella pneumoniae infection | Evaluation of polymyxin B AUC/MIC ratio for dose optimization in patients with carbapenem-resistant Klebsiella pneumoniae infection Abstract Polymyxin B has been used as a last-line therapy for the treatment of carbapenem-resistant gram-negative bacterial infection. The pharmacokinetic/pharmacodynamic index (AUC/MIC) o... |
PMC6312694 | core_pubmed_pmc | Formulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form | Formulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form Abstract Abstract Background This work aimed to develop a new solid dosage formulation of vinpocetine (VPN) in the form of buccal freeze-dried pullulan-based tablets (lyoplant-tabs) loa... |
PMC7017074 | core_pubmed_pmc | Krebs Cycle Intermediate-Modified Carbonate Apatite Nanoparticles Drastically Reduce Mouse Tumor Burden and Toxicity by Restricting Broad Tissue Distribution of Anticancer Drugs | Krebs Cycle Intermediate-Modified Carbonate Apatite Nanoparticles Drastically Reduce Mouse Tumor Burden and Toxicity by Restricting Broad Tissue Distribution of Anticancer Drugs Abstract The morphology, size, and surface area of nanoparticles (NPs), with the existence of functional groups on their surface, contribute t... |
PMC4166693 | core_pubmed_pmc | Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP) | Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP) Abstract Abstract Background Recombinant factor VIIa (rFVIIa) is approved for use in controlling bleeding episodes in people with hemophilia who have developed inhibitors to replacement therapy... |
PMC10184128 | core_pubmed_pmc | Development of a Potent Nurr1 Agonist Tool for In Vivo Applications | Development of a Potent Nurr1 Agonist Tool for In Vivo Applications Abstract Nuclear receptor related 1 (Nurr1) is a neuroprotective transcription factor and an emerging target in neurodegenerative diseases. Despite strong evidence for a role in Parkinson’s and Alzheimer’s disease, pharmacological control and validatio... |
PMC11510379 | core_pubmed_pmc | Development of a UHPLC-MS/MS Method for the Determination of Moxidectin in Rat Plasma and Its Application in Pharmacokinetics | Development of a UHPLC-MS/MS Method for the Determination of Moxidectin in Rat Plasma and Its Application in Pharmacokinetics Abstract The aim of the present study was to establish a simple and reliable ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method and apply it for the deter... |
PMC7496395 | core_pubmed_pmc | Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing | Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing Abstract Abstract BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclon... |
PMC5809790 | core_pubmed_pmc | Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence | Repeated Administration of Opra Kappa (LY2456302), a Novel, Short-Acting, Selective KOP-r Antagonist, in Persons with and without Cocaine Dependence Abstract Abstract The κ -opioid receptor (KOP-r) system and its endogenous ligands, the dynorphins, are involved in the neurobiological regulation of addictive states, and... |
PMC9298613 | core_pubmed_pmc | Effect of sinapic acid on aripiprazole pharmacokinetics in rats: Possible food drug interaction | Effect of sinapic acid on aripiprazole pharmacokinetics in rats: Possible food drug interaction Abstract Dietary supplements and foods can interact with various drugs, leading to possible clinical concerns. This study aimed to investigate the effect of orally administered sinapic acid (SA) on the pharmacokinetics of ar... |
PMC8179521 | core_pubmed_pmc | Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy † | Universal endogenous antibody recruiting nanobodies capable of triggering immune effectors for targeted cancer immunotherapy † Abstract Developing monoclonal antibodies (mAbs) for cancer immunotherapy is expensive and complicated. Nanobodies are small antibodies possessing favorable pharmacological properties compared ... |
PMC6273104 | core_pubmed_pmc | Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics | Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics Abstract Since many glycoside compounds in natural products are hydrolyzed by intestinal microbiota when administered orally, it is of interest to know whether their pharmacological effects are derived from the glycoside itself ... |
PMC6558371 | core_pubmed_pmc | Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza , in Rats | Preclinical Absorption, Distribution, Metabolism, and Excretion of Sodium Danshensu, One of the Main Water-Soluble Ingredients in Salvia miltiorrhiza , in Rats Abstract In this study, the absorption, distribution, metabolism and excretion (ADME) of sodium danshensu (Sodium DL-β-(3, 4-dihydroxyphenyl)lactate), one of th... |
PMC12087681 | core_pubmed_pmc | Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure‐Response Analysis | Optimizing Brentuximab Vedotin Dosing in Pediatric Patients with Advanced Hodgkin Lymphoma: A Population Pharmacokinetic and Exposure‐Response Analysis Abstract Abstract Pediatric patients with advanced‐stage newly diagnosed Hodgkin lymphoma (HL) were treated with brentuximab vedotin (BV) combined with adriamycin, vinb... |
PMC12158829 | core_pubmed_pmc | Considerations for Regulatory Reusability of Dynamic Tools in the New Drug Development | Considerations for Regulatory Reusability of Dynamic Tools in the New Drug Development Abstract Model-informed drug development (MIDD) approaches have become indispensable for new drug development and to address regulatory challenges. Dynamic tools, such as population pharmacokinetics (popPK), physiologically-based pha... |
PMC6447844 | core_pubmed_pmc | Phase I dose‐escalation study of capmatinib ( INC 280) in Japanese patients with advanced solid tumors | Phase I dose‐escalation study of capmatinib ( INC 280) in Japanese patients with advanced solid tumors Abstract Capmatinib is a highly specific, potent and selective MET inhibitor. This was an open‐label, multicenter, dose‐escalation, phase I study conducted in Japanese patients with advanced solid tumors (not selected... |
PMC12130804 | core_pubmed_pmc | Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with BRAF V600 -Mutant Metastatic Melanoma | Longitudinal Genomic Analysis to Fine-tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients with BRAF V600 -Mutant Metastatic Melanoma Abstract Abstract Purpose: LOGIC 2 ( NCT02159066 ), a multicenter, open-label, two-part, phase II study, assessed encorafenib plus binimetinib combined with a third t... |
PMC3281999 | core_pubmed_pmc | Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate | Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate Abstract Abstract This study aimed to investigate the use of quinidine microdialysis to study potential changes in brain P-glycoprotein functionality a... |
PMC10224453 | core_pubmed_pmc | Systematic Review and Meta-Analysis of the Effect of Loop Diuretics on Antibiotic Pharmacokinetics | Systematic Review and Meta-Analysis of the Effect of Loop Diuretics on Antibiotic Pharmacokinetics Abstract Loop diuretics and antibiotics are commonly co-prescribed across many clinical care settings. Loop diuretics may alter antibiotic pharmacokinetics (PK) via several potential drug interactions. A systematic review... |
PMC5658288 | core_pubmed_pmc | PharmML in Action: an Interoperable Language for Modeling and Simulation | PharmML in Action: an Interoperable Language for Modeling and Simulation Abstract PharmML 1 is an XML‐based exchange format 2 , 3 , 4 created with a focus on nonlinear mixed‐effect (NLME) models used in pharmacometrics, 5 , 6 but providing a very general framework that also allows describing mathematical and statistica... |
PMC9775397 | core_pubmed_pmc | Pharmacogenetics and Schizophrenia—Can Genomics Improve the Treatment with Second-Generation Antipsychotics? | Pharmacogenetics and Schizophrenia—Can Genomics Improve the Treatment with Second-Generation Antipsychotics? Abstract Abstract Schizophrenia (SCZ) is a complex psychiatric disorder of multifactorial origin, in which both genetic and environmental factors have an impact on its onset, course, and outcome. Large variabili... |
PMC12890486 | core_pubmed_pmc | Cannabidiol exerts antiinflammatory effects but maintains T effector memory cell differentiation in humans | Cannabidiol exerts antiinflammatory effects but maintains T effector memory cell differentiation in humans Abstract Abstract BACKGROUND Cannabidiol (CBD) is increasingly used for pain management, including in transplant recipients with limited analgesic options. Its immunomodulatory effects in humans are not well defin... |
PMC11215134 | core_pubmed_pmc | Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest | Comparison of intranasal naloxone and intranasal nalmefene in a translational model assessing the impact of synthetic opioid overdose on respiratory depression and cardiac arrest Abstract Abstract Introduction Using a validated translational model that quantitatively predicts opioid-induced respiratory depression and c... |
PMC3532357 | core_pubmed_pmc | Functional Profiling of Live Melanoma Samples Using a Novel Automated Platform | Functional Profiling of Live Melanoma Samples Using a Novel Automated Platform Abstract Aims This proof-of-concept study was designed to determine if functional, pharmacodynamic profiles relevant to targeted therapy could be derived from live human melanoma samples using a novel automated platform. Methods A series of ... |
PMC10135351 | core_pubmed_pmc | Phytochemicals in Gastrointestinal Nematode Control: Pharmacokinetic–Pharmacodynamic Evaluation of the Ivermectin plus Carvone Combination | Phytochemicals in Gastrointestinal Nematode Control: Pharmacokinetic–Pharmacodynamic Evaluation of the Ivermectin plus Carvone Combination Abstract Abstract Simple Summary In the last 50 years, limited modern drugs with new mechanisms of action have been incorporated; consequently, drug resistance has increased worldwi... |
PMC12755099 | core_pubmed_pmc | Xenin-Derived Peptides: Multifaceted Regulators and Therapeutic Innovations in Metabolic Diseases | Xenin-Derived Peptides: Multifaceted Regulators and Therapeutic Innovations in Metabolic Diseases Abstract Abstract Xenin, a 25-amino acid peptide hormone predominantly secreted by intestinal K cells, demonstrates evolutionary conservation with neuropeptides such as xenopsin and neurotensin. Functionally, it engages ne... |
PMC9349773 | core_pubmed_pmc | Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID ‐19, in Subjects With Renal Impairment | Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID ‐19, in Subjects With Renal Impairment Abstract Nirmatrelvir coadministered with ritonavir is highly efficacious in reducing the risk of coronavirus disease 2019 (COVID‐19) adverse outcomes among patients at increased risk of p... |
PMC9652116 | core_pubmed_pmc | The Limitations and Unmet Needs of the Five Cornerstones to Guarantee Lifelong Optimization of Prophylaxis in Hemophilia Patients | The Limitations and Unmet Needs of the Five Cornerstones to Guarantee Lifelong Optimization of Prophylaxis in Hemophilia Patients Abstract Prophylaxis to prevent bleeding is highly recommended for hemophilia patients. The development of new drugs and tools for modeling personalized prophylaxis provides the means for pe... |
PMC12410301 | core_pubmed_pmc | [ 64 Cu]Cu-NOTA-EV-F(ab′) 2 Enables Same-Day Immuno-PET Imaging of Nectin-4 in Triple-Negative Breast and Urothelial Bladder Cancers | [ 64 Cu]Cu-NOTA-EV-F(ab′) 2 Enables Same-Day Immuno-PET Imaging of Nectin-4 in Triple-Negative Breast and Urothelial Bladder Cancers Abstract Our study aimed to develop and evaluate [ 64 Cu]Cu-NOTA-EV-F(ab′) 2 for immuno-PET imaging of nectin-4 expression in triple-negative breast cancer (TNBC) and urothelial bladder c... |
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