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PMC11052790 | core_pubmed_pmc | Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers | Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers Abstract Abstract Background We investigated the effect of a 5-day low-dose ritonavir therapy, as it is used in the treatment of COVID-19 with ni... |
PMC6227840 | core_pubmed_pmc | Pharmacokinetics of Vancomycin in Patients with Different Renal Function Levels | Pharmacokinetics of Vancomycin in Patients with Different Renal Function Levels Abstract Abstract There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim o... |
PMC12191815 | core_pubmed_pmc | Genetic Mechanisms of Antimicrobial Non-Susceptibility to Novel Fluoroquinolone Delafloxacin Among Bulgarian Clinical Isolates of Streptococcus agalactiae | Genetic Mechanisms of Antimicrobial Non-Susceptibility to Novel Fluoroquinolone Delafloxacin Among Bulgarian Clinical Isolates of Streptococcus agalactiae Abstract Delafloxacin is one of the newest fluoroquinolones with a unique structure, determining better pharmacokinetic and pharmacodynamic properties, a better safe... |
PMC8709907 | core_pubmed_pmc | Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma | Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma Abstract Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem tumor for which radiation is the only treatment. Case studies report a clinical response to... |
PMC8614650 | core_pubmed_pmc | Effects of Growth Medium and Inoculum Size on Pharmacodynamics Activity of Marbofloxacin against Staphylococcus aureus Isolated from Caprine Clinical Mastitis | Effects of Growth Medium and Inoculum Size on Pharmacodynamics Activity of Marbofloxacin against Staphylococcus aureus Isolated from Caprine Clinical Mastitis Abstract Abstract Staphylococcus aureus ( S. aureus ) is an important pathogen that causes clinical mastitis in goats and produces infections difficult to cure. ... |
PMC10763448 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers | Pharmacokinetics and pharmacodynamics of perfluoropropane after intra-venous bolus injection of perflutren lipid microsphere injection (DEFINITY®) in healthy Chinese volunteers Abstract Background and objective Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), als... |
PMC10444824 | core_pubmed_pmc | Predicting the molecular mechanism-driven progression of breast cancer through comprehensive network pharmacology and molecular docking approach | Predicting the molecular mechanism-driven progression of breast cancer through comprehensive network pharmacology and molecular docking approach Abstract Abstract Identification of key regulators is a critical step toward discovering biomarker that participate in BC. A gene expression dataset of breast cancer patients ... |
PMC6339746 | core_pubmed_pmc | Quantification of Lappaconitine in Mouse Blood by UPLC-MS/MS and Its Application to a Pharmacokinetic Study | Quantification of Lappaconitine in Mouse Blood by UPLC-MS/MS and Its Application to a Pharmacokinetic Study Abstract Lappaconitine is extracted from Aconitum sinomontanum Nakai, which belongs to the Ranunculaceae. Lappaconitine is as a diterpenoid alkaloid used as a nonaddictive analgesic. To assure the rational use of... |
PMC12594730 | core_pubmed_pmc | QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations | QT interval prolongation: clinical assessment, risk factors and quantitative pharmacological considerations Abstract Abstract Prolongation of the QT interval in the ECG is a critical finding that signifies an extended duration from the onset of ventricular depolarization to the end of ventricular repolarization. It can... |
PMC7417410 | core_pubmed_pmc | Population pharmacokinetics–pharmacodynamics of sunitinib in pediatric patients with solid tumors | Population pharmacokinetics–pharmacodynamics of sunitinib in pediatric patients with solid tumors Abstract Purpose The safety profile of sunitinib in children, including the impact of sunitinib exposure on safety endpoints, was assessed using population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PK–PD) m... |
PMC10640521 | core_pubmed_pmc | Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis | Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis Abstract Introduction The factors related to the ocular penetration of drugs after the administration of eye drops in humans have not been examined in detail. Therefore, this study assessed the inf... |
PMC8743345 | core_pubmed_pmc | Cysteamine bitartrate delayed‐release capsules control leukocyte cystine levels and promote statural growth and kidney health in an open‐label study of treatment‐naïve patients <6 years of age with nephropathic cystinosis | Cysteamine bitartrate delayed‐release capsules control leukocyte cystine levels and promote statural growth and kidney health in an open‐label study of treatment‐naïve patients <6 years of age with nephropathic cystinosis Abstract Abstract Nephropathic cystinosis is a rare autosomal recessive lysosomal storage disease ... |
PMC8212709 | core_pubmed_pmc | A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects | A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects Abstract Abstract Bruton’s tyrosine kinase (BTK) is a target for treatment of hematologic malignancies and autoimmune diseases. TAK‐020 is a highly selective covalent BTK ... |
PMC6708059 | core_pubmed_pmc | Convergence of Cell Pharmacology and Drug Delivery | Convergence of Cell Pharmacology and Drug Delivery Abstract Summary Cellular therapy is enabling new approaches to tackle significant unmet needs in areas such as regenerative medicine and immunotherapy. The pharmacology of cell therapeutics becomes of critical importance to assure that these new drugs work reproducibl... |
PMC3880470 | core_pubmed_pmc | Pharmacokinetics of Mirabegron, a β 3 -Adrenoceptor Agonist for Treatment of Overactive Bladder, in Healthy Japanese Male Subjects: Results from Single- and Multiple-Dose Studies | Pharmacokinetics of Mirabegron, a β 3 -Adrenoceptor Agonist for Treatment of Overactive Bladder, in Healthy Japanese Male Subjects: Results from Single- and Multiple-Dose Studies Abstract Abstract Background Mirabegron is a human β 3 -adrenoceptor agonist for the treatment of overactive bladder. The pharmacokinetic pro... |
PMC10665782 | core_pubmed_pmc | Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS | Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS Abstract Abstract Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacoki... |
PMC9540480 | core_pubmed_pmc | Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need | Applying Modeling and Simulations for Rational Dose Selection of Novel Toll‐Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need Abstract Dual toll‐like receptor (TLR) 7 and TLR8 inhibitor enpatoran is under investigation as a treatment for lupus and coronavirus disease 2019 (COVID‐19) pneumonia. ... |
PMC9944491 | core_pubmed_pmc | Haemophilia A: A Review of Clinical Manifestations, Treatment, Mutations, and the Development of Inhibitors | Haemophilia A: A Review of Clinical Manifestations, Treatment, Mutations, and the Development of Inhibitors Abstract The purpose of this narrative review was to provide an overview that allows readers to improve their understanding of hemophilia A, which is considered a genetic disease with a high impact on the quality... |
PMC10858190 | core_pubmed_pmc | Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion | Mitigating non-genetic resistance to checkpoint inhibition based on multiple states of immune exhaustion Abstract Abstract Despite the revolutionary impact of immune checkpoint inhibition on cancer therapy, the lack of response in a subset of patients, as well as the emergence of resistance, remain significant challeng... |
PMC5911476 | core_pubmed_pmc | Novel Antimicrobials for the Treatment of Clostridium difficile Infection | Novel Antimicrobials for the Treatment of Clostridium difficile Infection Abstract Abstract The current picture of Clostridium difficile infection (CDI) is alarming with a mortality rate ranging between 3% and 15% and a CDI recurrence rate ranging from 12% to 40%. Despite the great efforts made over the past 10 years t... |
PMC12129139 | core_pubmed_pmc | Obesity-related drug-metabolizing enzyme expression alterations in the human liver | Obesity-related drug-metabolizing enzyme expression alterations in the human liver Abstract Abstract Objective: Implications of obesity extend beyond the association with various health conditions, impacting physiological changes that affect the liver and the activity of metabolizing enzymes. Given the prevalence of ob... |
PMC10130658 | core_pubmed_pmc | Sinapis Semen: A review on phytochemistry, pharmacology, toxicity, analytical methods and pharmacokinetics | Sinapis Semen: A review on phytochemistry, pharmacology, toxicity, analytical methods and pharmacokinetics Abstract Abstract Sinapis Semen (SS), the dried mature seed of Sinapis alba L. and Brassica juncea (L.) Czern. et Coss., is one of the traditional Chinese medicinal materials with a wide range of pharmacological e... |
PMC10769996 | core_pubmed_pmc | Characterization of the Pharmacokinetics and Mass Balance of a Single Oral Dose of Trofinetide in Healthy Male Subjects | Characterization of the Pharmacokinetics and Mass Balance of a Single Oral Dose of Trofinetide in Healthy Male Subjects Abstract Background and Objective Trofinetide is the first drug to be approved for the treatment of Rett syndrome, a neurodevelopmental disorder. The purpose of the study is to fully characterize the ... |
PMC7292816 | core_pubmed_pmc | Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis | Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis Abstract Abstract Background Application of idarucizumab and hemodialysis are options to reverse the action of the oral anticoagulant dabigatran in emergency situations. Objectives The objectives o... |
PMC12228451 | core_pubmed_pmc | Development and validation of an innovative approach to estimating FVIII levels and designing personalised doses in the prophylactic treatment of haemophilia A: based on the principle of the two-compartment model | Development and validation of an innovative approach to estimating FVIII levels and designing personalised doses in the prophylactic treatment of haemophilia A: based on the principle of the two-compartment model Abstract Abstract Objective To predict the level at a specified time and design personalised dosing, we pro... |
PMC3975707 | core_pubmed_pmc | The effect of food on the pharmacokinetics of oral fluralaner in dogs | The effect of food on the pharmacokinetics of oral fluralaner in dogs Abstract Background Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. This study investigate... |
PMC10535516 | core_pubmed_pmc | The Use of Tricaine Methanesulfonate (MS-222) in Asian Seabass ( Lates calcarifer ) at Different Temperatures: Study of Optimal Doses, Minimum Effective Concentration, Blood Biochemistry, Immersion Pharmacokinetics, and Tissue Distributions | The Use of Tricaine Methanesulfonate (MS-222) in Asian Seabass ( Lates calcarifer ) at Different Temperatures: Study of Optimal Doses, Minimum Effective Concentration, Blood Biochemistry, Immersion Pharmacokinetics, and Tissue Distributions Abstract Abstract Simple Summary The optimal use of tricaine methanesulfonate (... |
PMC9298630 | core_pubmed_pmc | Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation | Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation Abstract The traditional Chinese herbal formula Shenmai-Yin (SY) and nifedipine have both been used to treat patients with cardiovascular disorders. Nifedipine is primarily oxidized by cytochr... |
PMC7076055 | core_pubmed_pmc | [ 89 Zr]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer | [ 89 Zr]Zr-cetuximab PET/CT as biomarker for cetuximab monotherapy in patients with RAS wild-type advanced colorectal cancer Abstract Abstract Purpose One-third of patients with RAS wild-type mCRC do not benefit from anti-EGFR monoclonal antibodies. This might be a result of variable pharmacokinetics and insufficient t... |
PMC7499189 | core_pubmed_pmc | Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity | Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity Abstract Abstract Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al . 1 to describe drug‐induced hematotoxicity is w... |
PMC6304248 | core_pubmed_pmc | Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study | Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study Abstract Abstract Background Many novel drug delivery systems have been extensively studied to exploit the full therapeutic potential of SN38, which is one of the most potent antitumor analogs of camptothecins (CPTs), whose clinic... |
PMC5895137 | core_pubmed_pmc | CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients | CSL112 (Apolipoprotein A-I [Human]) Enhances Cholesterol Efflux Similarly in Healthy Individuals and Stable Atherosclerotic Disease Patients Abstract Supplemental Digital Content is available in the text. Keywords: apolipoproteins, atherosclerosis, clinical trial, coronary disease, high density lipoprotein-1 Abstract O... |
PMC4356204 | core_pubmed_pmc | Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug | Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug Abstract Objectives Bedaquiline is the first drug of a new class approved for the treatment of TB in decades. Bedaquiline is metabolized by cytochrome P450 (CYP) 3A4 to a less-active M2 metabolite. Its terminal half-life i... |
PMC7745756 | core_pubmed_pmc | Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment | Recommendations for Dosing of Repurposed COVID-19 Medications in Patients with Renal and Hepatic Impairment Abstract Introduction In December 2019, an outbreak of a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began, resulting in a number of antivirals and immune modulators being repurposed to tre... |
PMC6878905 | core_pubmed_pmc | Effects of CYP3A4 Polymorphisms on Drug Addiction Risk Among the Chinese Han Population | Effects of CYP3A4 Polymorphisms on Drug Addiction Risk Among the Chinese Han Population Abstract Background: Cytochrome P450 3A4 ( CYP3A4 ) regulates pharmacokinetic and pharmacodynamic interactions during the process of drug absorption and metabolism, suggesting CYP3A4 plays an important role in drug addiction. Howeve... |
PMC10337722 | core_pubmed_pmc | Barium silicate nanoparticles, an efficient catalyst for one-pot green synthesis of α-benzyl amino coumarin derivatives as potential chemotherapeutic agents † | Barium silicate nanoparticles, an efficient catalyst for one-pot green synthesis of α-benzyl amino coumarin derivatives as potential chemotherapeutic agents † Abstract Abstract A new, simple, and efficient method for synthesis of α-benzyl amino coumarin and its derivatives (1–24) is described via a one-pot, three-compo... |
PMC11067698 | core_pubmed_pmc | Assessment of Efficacy and Safety of Zagotenemab | Assessment of Efficacy and Safety of Zagotenemab Abstract Abstract Background and Objectives Zagotenemab (LY3303560), a monoclonal antibody that preferentially targets misfolded, extracellular, aggregated tau, was assessed in the PERISCOPE-ALZ phase 2 study to determine its ability to slow cognitive and functional decl... |
PMC9894673 | core_pubmed_pmc | Pharmacokinetic Alterations Associated with Critical Illness | Pharmacokinetic Alterations Associated with Critical Illness Abstract Abstract Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect drug pharmacokinetics and pharmacodynamics making dose optimisation particularly challenging. Appropriate therapeutic dosing depends on the knowledge of ... |
PMC5834087 | core_pubmed_pmc | Assessment of nivolumab benefit–risk profile of a 240-mg flat dose relative to a 3-mg/kg dosing regimen in patients with advanced tumors | Assessment of nivolumab benefit–risk profile of a 240-mg flat dose relative to a 3-mg/kg dosing regimen in patients with advanced tumors Abstract Abstract Background Nivolumab 3 mg/kg every 2 weeks (Q2W) has shown benefit versus the standard of care in melanoma, non-small cell lung cancer (NSCLC), and renal cell carcin... |
PMC9852958 | core_pubmed_pmc | Synopsis of the pharmacokinetics, pharmacodynamics, applications, and safety of firocoxib in horses | Synopsis of the pharmacokinetics, pharmacodynamics, applications, and safety of firocoxib in horses Abstract According to in vitro and in vivo investigations, firocoxib (FX), a second-generation coxib, is a highly selective COX-2 inhibitor in horses. With a COX-1/COX-2 IC 50 ratio of 643 in horses, FX spares the COX-1 ... |
PMC9110059 | core_pubmed_pmc | Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics | Mechanistic Models of COVID-19: Insights into Disease Progression, Vaccines, and Therapeutics Abstract Abstract The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new... |
PMC10329699 | core_pubmed_pmc | Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides | Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides Abstract Abstract Cell-penetrating peptides (CPPs) have been used in basic and preclinical research in the past 30 years to facilitate drug delivery into target cells. However, translation toward the clinic has not been successful so fa... |
PMC11867924 | core_pubmed_pmc | Exposure‐Efficacy Analysis and Dopamine D2 Receptor Occupancy in Adults with Schizophrenia after Treatment with the Monthly Intramuscular Injectable Risperidone ISM | Exposure‐Efficacy Analysis and Dopamine D2 Receptor Occupancy in Adults with Schizophrenia after Treatment with the Monthly Intramuscular Injectable Risperidone ISM Abstract Abstract Dopamine D2 receptor occupancy (D2RO) significantly influences the clinical effectiveness and safety of many antipsychotic drugs. Maintai... |
PMC9239973 | core_pubmed_pmc | Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury | Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injury Abstract Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis, necroptosis, and other types of cell death, is characterized by lipid peroxidation, reactive oxygen spec... |
PMC10482275 | core_pubmed_pmc | Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis | Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis Abstract Abstract Moxidectin (MOX) is a milbemycin endectocide recently approved by the U.S. FDA for the treatment of onchocerciasis in persons at least 12 years of age. MOX has been shown to have ... |
PMC10720512 | core_pubmed_pmc | Semi-mechanistic population pharmacokinetic/pharmacodynamic modeling of a Plasmodium elongation factor 2 inhibitor cabamiquine for prevention and cure of malaria | Semi-mechanistic population pharmacokinetic/pharmacodynamic modeling of a Plasmodium elongation factor 2 inhibitor cabamiquine for prevention and cure of malaria Abstract ABSTRACT Cabamiquine is a novel antimalarial agent that demonstrates the potential for chemoprevention and treatment of malaria. In this article, the... |
PMC6272970 | core_pubmed_pmc | Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals | Natural Deep Eutectic Solvents (NADES) as a Tool for Bioavailability Improvement: Pharmacokinetics of Rutin Dissolved in Proline/Glycine after Oral Administration in Rats: Possible Application in Nutraceuticals Abstract There is a need for innovation in plant-derived pharmaceuticals, food supplements and nutraceutical ... |
PMC11043595 | core_pubmed_pmc | In vitro pharmacokinetics/pharmacodynamics of FL058 (a novel beta-lactamase inhibitor) combined with meropenem against carbapenemase-producing Enterobacterales | In vitro pharmacokinetics/pharmacodynamics of FL058 (a novel beta-lactamase inhibitor) combined with meropenem against carbapenemase-producing Enterobacterales Abstract Objective: FL058 is a novel beta-lactamase inhibitor with a broad spectrum of activity and a favorable safety profile. The objective of this study was ... |
PMC11207335 | core_pubmed_pmc | In Vitro Metabolism and Transport Characteristics of Zastaprazan | In Vitro Metabolism and Transport Characteristics of Zastaprazan Abstract Zastaprazan (JP-1366), a novel potassium-competitive acid blocker, is a new drug for the treatment of erosive esophagitis. JP-1366 is highly metabolized in human, mouse, and dog hepatocytes but moderately metabolized in rat and monkey hepatocytes... |
PMC3032523 | core_pubmed_pmc | Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins | Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins Abstract Abstract In an attempt to improve TRAIL's (tumor necrosis factor-related apoptosis-inducing ligand) tumor selective activity a variant was designed, in which the three TRAIL protomers are expressed as a singl... |
PMC7728716 | core_pubmed_pmc | Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration | Pharmacokinetics and Tissue Levels of Pantoprazole in Neonatal Calves After Intravenous Administration Abstract Abstract Background: Neonatal calves are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for potential anti-ulcerative therapies, such as pantoprazole, in ruminant speci... |
PMC4702416 | core_pubmed_pmc | Randomized, active-controlled, comparative phase 3 efficacy and safety equivalence trial of Ovaleap® (recombinant human follicle-stimulating hormone) in infertile women using assisted reproduction technology (ART) | Randomized, active-controlled, comparative phase 3 efficacy and safety equivalence trial of Ovaleap® (recombinant human follicle-stimulating hormone) in infertile women using assisted reproduction technology (ART) Abstract Abstract Background Pharmacokinetic studies with XM17 (Ovaleap®), a recombinant human follicle-st... |
PMC3047975 | core_pubmed_pmc | Pharmacology, efficacy and safety of liraglutide in the management of type 2 diabetes | Pharmacology, efficacy and safety of liraglutide in the management of type 2 diabetes Abstract Liraglutide is a glucagon-like peptide-1 analog with pharmacokinetic properties suitable for once-daily administration approved by the Food and Drug Administration for the treatment of patients with type 2 diabetes. Clinical ... |
PMC12715044 | core_pubmed_pmc | Spatial Pharmacokinetic and Pharmacodynamic Modeling in Airway Mucus | Spatial Pharmacokinetic and Pharmacodynamic Modeling in Airway Mucus Abstract Background and Objectives Diseases such as cystic fibrosis (CF) and non-CF bronchiectasis can cause extensive mucus formation in the lung, which may affect drug distribution and effects. As such, quantitative understanding of drug distributio... |
PMC7371857 | core_pubmed_pmc | Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects | Modeling Pathway Dynamics of the Skeletal Muscle Response to Intravenous Methylprednisolone (MPL) Administration in Rats: Dosing and Tissue Effects Abstract Abstract A model-based approach for the assessment of pathway dynamics is explored to characterize metabolic and signaling pathway activity changes characteristic ... |
PMC8866227 | core_pubmed_pmc | Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma | Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma Abstract Abstract Purpose: There is increasing recognition that progress in immuno-oncology could be accelerated by evaluating immune-based ... |
PMC6611044 | core_pubmed_pmc | Pharmacokinetic analysis of new synthetic antimalarial N-251 | Pharmacokinetic analysis of new synthetic antimalarial N-251 Abstract Abstract Background With the emergence and growing number of drug-resistant Plasmodium falciparum , a new drug for malaria control must be urgently developed. The new antimalarial synthetic compound N-251 was recently discovered. As an endoperoxide s... |
PMC5999140 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor | Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor Abstract Abstract Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein cholesterol (LDL-C) by decreasing expression of the LDL receptor on hepatic cells. Evolocumab is a human monoclonal immunoglobu... |
PMC9325164 | core_pubmed_pmc | Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits | Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits Abstract The aim of this study was the successful utilization of the positively charged nanocrystals (NCs) of Tedizolid Phosphate (TZP) (0.1% w / v ) for topical ocular applications. TZP belongs to the 1, 3... |
PMC11972901 | core_pubmed_pmc | Minocycline Susceptibility of Carbapenem-Resistant Acinetobacter baumannii Blood Isolates from a Single Center in Korea: Role of tetB in Resistance | Minocycline Susceptibility of Carbapenem-Resistant Acinetobacter baumannii Blood Isolates from a Single Center in Korea: Role of tetB in Resistance Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) represents a devastating and growing global threat, calling for new antibiotic treatments. In Korea,... |
PMC4338135 | core_pubmed_pmc | Ozanezumab Dose Selection for Amyotrophic Lateral Sclerosis by Pharmacokinetic-Pharmacodynamic Modelling of Immunohistochemistry Data from Patient Muscle Biopsies | Ozanezumab Dose Selection for Amyotrophic Lateral Sclerosis by Pharmacokinetic-Pharmacodynamic Modelling of Immunohistochemistry Data from Patient Muscle Biopsies Abstract Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal neurodegenerative disease with a high unmet medical need. In this context, a potential thera... |
PMC6458767 | core_pubmed_pmc | Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain | Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain Abstract Abstract Background Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxica... |
PMC8300337 | core_pubmed_pmc | Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing–Preliminary Investigation | Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing–Preliminary Investigation Abstract Simple Summary Rational use of antibiotic is of most importance for human and animal health. Donkeys have differences in metabolism compared to ... |
PMC2984539 | core_pubmed_pmc | How pharmacokinetic and pharmacodynamic principles pave the way for optimal basal insulin therapy in type 2 diabetes | How pharmacokinetic and pharmacodynamic principles pave the way for optimal basal insulin therapy in type 2 diabetes Abstract This pedagogical review illustrates the differences between pharmacokinetic (PK) and pharmacodynamic (PD) measures, using insulin therapy as the primary example. The main conclusion is that PD p... |
PMC12382683 | core_pubmed_pmc | Pharmacokinetics of Tolfenamic Acid Administered Orally and Intravenously at Different Doses in Pekin Ducks ( Anas platyrhynchos domestica ) | Pharmacokinetics of Tolfenamic Acid Administered Orally and Intravenously at Different Doses in Pekin Ducks ( Anas platyrhynchos domestica ) Abstract Simple Summary This study examined how tolfenamic acid behaves in Pekin ducks when given either intravenously or orally at different doses. The key findings showed that w... |
PMC8880217 | core_pubmed_pmc | Model-Based Equivalent Dose Optimization to Develop New Donepezil Patch Formulation | Model-Based Equivalent Dose Optimization to Develop New Donepezil Patch Formulation Abstract Abstract Donepezil patch was developed to replace the original oral formulation. To accurately describe the pharmacokinetics of donepezil and investigate compatible doses between two formulations, a population pharmacokinetic m... |
PMC3931386 | core_pubmed_pmc | The Pharmacogenetics of Type 2 Diabetes: A Systematic Review | The Pharmacogenetics of Type 2 Diabetes: A Systematic Review Abstract Abstract OBJECTIVE We performed a systematic review to identify which genetic variants predict response to diabetes medications. RESEARCH DESIGN AND METHODS We performed a search of electronic databases (PubMed, EMBASE, and Cochrane Database) and a m... |
PMC9144241 | core_pubmed_pmc | Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function | Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function Abstract Cannabidiol (CBD) is widely available and marketed as having therapeutic properties. Over-the-counter CBD is unregulated, many of the therapeutic claims lack scientific support, and controversy exi... |
PMC10188378 | core_pubmed_pmc | Ustekinumab Trough Concentrations Are Associated with Biochemical Outcomes in Patients with Crohn’s Disease | Ustekinumab Trough Concentrations Are Associated with Biochemical Outcomes in Patients with Crohn’s Disease Abstract Objective It is unknown whether ustekinumab (UST) levels can predict clinical outcomes in Crohn’s disease (CD) patients. We assessed the exposure–response relationship of UST trough concentrations with b... |
PMC11934747 | core_pubmed_pmc | Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation | Pharmacokinetics of post-transplant cyclophosphamide and its associations with clinical outcomes in pediatric haploidentical hematopoietic stem cell transplantation Abstract Abstract Background Post-transplantation cyclophosphamide (PTCy) has paved the way for the increased use of alternative donors, including haploide... |
PMC4213378 | core_pubmed_pmc | Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma | Pharmacokinetics and Efficacy of the Spleen Tyrosine Kinase Inhibitor R406 after Ocular Delivery for Retinoblastoma Abstract Purpose Retinoblastoma is a childhood cancer of the retina. Clinical trials have shown that local delivery of broad spectrum chemotherapeutic agents is efficacious. Recent studies characterizing ... |
PMC9704759 | core_pubmed_pmc | Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models | Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models Abstract Abstract Blood pressure (BP) follows a circadian variation, increasing during active hours, showing a small postprandial valley and a deeper decrease during sleep. Nighttime redu... |
PMC7690806 | core_pubmed_pmc | Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone | Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone Abstract About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Approximately 75% of the world pop... |
PMC10008152 | core_pubmed_pmc | Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial | Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial Abstract Abstract Background Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proli... |
PMC5420810 | core_pubmed_pmc | Screening of conventional anticonvulsants in a genetic mouse model of epilepsy | Screening of conventional anticonvulsants in a genetic mouse model of epilepsy Abstract Abstract Objective Epilepsy is a common neurological disorder that affects 1% of the population. Approximately, 30% of individuals with epilepsy are refractory to treatment, highlighting the need for novel therapies. Conventional an... |
PMC3986720 | core_pubmed_pmc | Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice | Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice Abstract Abstract Pharmacokinetic interactions, e.g. modulation of drug transporters like P-glycoprotein at the blood-brain barrier, can be a reason for treatment non-response. This study focuses on the influence of induction of drug tra... |
PMC6497258 | core_pubmed_pmc | Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation | Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation Abstract Abstract Many parameters treated as constants in traditional physiologically based pharmacokinetic models must be formulated as time-varying quantities when modeling pregnancy and gestation due ... |
PMC7993257 | core_pubmed_pmc | Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling | Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling Abstract Sjögren’s syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid‐based specialized pro‐resolving mediators that showed efficacy in preclinica... |
PMC9796419 | core_pubmed_pmc | Effect Compartment Model for the Evaluation of Tolerance to Psychological Highness Following Smoking Marijuana | Effect Compartment Model for the Evaluation of Tolerance to Psychological Highness Following Smoking Marijuana Abstract Abstract The purpose of this study is to evaluate the development of tolerance, using a population modeling approach, in recreational marijuana users after acute pulmonary administration of tetrahydro... |
PMC5354739 | core_pubmed_pmc | Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma | Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma Abstract Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway. Correlations between polymorphisms and pharmacokinetic p... |
PMC11645446 | core_pubmed_pmc | Pharmacokinetic study of polymyxin B in healthy subjects and subjects with renal insufficiency | Pharmacokinetic study of polymyxin B in healthy subjects and subjects with renal insufficiency Abstract Abstract Polymyxin B is a viable option for treating antibiotic‐resistant infections; however, current data on its pharmacokinetics, particularly in patients with renal insufficiency, remain inconclusive and necessit... |
PMC9780658 | core_pubmed_pmc | Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance | Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance Abstract Abstract Background: Postmarketing safety analysis is an effective supplement for new drugs in clinical practice. Therefore, we aimed to systematically assess the safety of oral nemonoxacin malate, the first appro... |
PMC10747454 | core_pubmed_pmc | The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass | The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass Abstract Abstract Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability. In this work, sildenafi... |
PMC11685455 | core_pubmed_pmc | Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host | Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein–Bar virus in host Abstract Abstract The Epstein–Barr virus (EBV) is widespread and has been related to a variety of malignancies as well as infectious mononucleosis. Despite the lack of a va... |
PMC6656941 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants | Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants Abstract Abstract Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adu... |
PMC7195756 | core_pubmed_pmc | Niosomes of active Fumaria officinalis phytochemicals: antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action | Niosomes of active Fumaria officinalis phytochemicals: antidiabetic, antineuropathic, anti-inflammatory, and possible mechanisms of action Abstract Background Fumaria officinalis ( F. officinalis, FO) has been used in many inflammatory and painful-ailments. The main aim of this work is to perform an in-depth bio-guided... |
PMC12655709 | core_pubmed_pmc | Artificial Intelligence (AI) in Pharmaceutical Formulation and Dosage Calculations | Artificial Intelligence (AI) in Pharmaceutical Formulation and Dosage Calculations Abstract Artificial intelligence (AI) is reforming pharmaceutical sciences by renovating traditional drug formulation and dosage calculation approaches. This review provides a comprehensive overview of how AI technologies, such as machin... |
PMC5620576 | core_pubmed_pmc | Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative | Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative Abstract Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox’s bioava... |
PMC3082021 | core_pubmed_pmc | Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study | Increasing tumoral 5-fluorouracil concentrations during a 5-day continuous infusion: a microdialysis study Abstract Abstract Purpose Response to anticancer therapy is believed to be directly related to the concentration of the anticancer drug in the tumor itself. Assessment of intra-tumor drug pharmacokinetics can be h... |
PMC3609526 | core_pubmed_pmc | Enhanced Absorption of Insulin Aspart as the Result of a Dispersed Injection Strategy Tested in a Randomized Trial in Type 1 Diabetic Patients | Enhanced Absorption of Insulin Aspart as the Result of a Dispersed Injection Strategy Tested in a Randomized Trial in Type 1 Diabetic Patients Abstract Abstract OBJECTIVE We investigated the impact of two different injection strategies on the pharmacokinetics and pharmacodynamics of insulin aspart in vivo in an open-la... |
PMC6522576 | core_pubmed_pmc | Teaching an Old Class New Tricks: A Novel Semi-Synthetic Aminoglycoside, Plazomicin | Teaching an Old Class New Tricks: A Novel Semi-Synthetic Aminoglycoside, Plazomicin Abstract The emergence of multi-drug resistant (MDR) Gram-negative pathogens has become a serious worldwide health concern. Gram-negative bacteria such as Enterobacteriaceae ( Klebsiella pneumoniae , Escherichia coli , Enterobacter spp.... |
PMC11944414 | core_pubmed_pmc | Leveraging Omeprazole PBPK/PD Modeling to Inform Drug–Drug Interactions and Specific Recommendations for Pediatric Labeling | Leveraging Omeprazole PBPK/PD Modeling to Inform Drug–Drug Interactions and Specific Recommendations for Pediatric Labeling Abstract Background/Objectives: Omeprazole is widely used for managing gastrointestinal disorders like GERD, ulcers, and H. pylori infections. However, its use in pediatrics presents challenges du... |
PMC9111087 | core_pubmed_pmc | Quantitative methods and modeling to assess COVID‐19‐interrupted in vivo pharmacokinetic bioequivalence studies with two reference batches | Quantitative methods and modeling to assess COVID‐19‐interrupted in vivo pharmacokinetic bioequivalence studies with two reference batches Abstract Abstract The coronavirus disease 2019 (COVID‐19) has presented unprecedented challenges to the generic drug development, including interruptions in bioequivalence (BE) stud... |
PMC11971949 | core_pubmed_pmc | Optimizing Tacrolimus Dosing During Hospitalization After Kidney Transplantation: A Comparative Model Analysis | Optimizing Tacrolimus Dosing During Hospitalization After Kidney Transplantation: A Comparative Model Analysis Abstract Background The optimization of tacrolimus dosing during the early postoperative hospitalization period is essential to prevent rejection, minimize nephrotoxicity, and minimize the risk of opportunisti... |
PMC5897417 | core_pubmed_pmc | Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats | Comparative Pharmacokinetics of Gallic Acid After Oral Administration of Gallic Acid Monohydrate in Normal and Isoproterenol-Induced Myocardial Infarcted Rats Abstract Gallic acid (GA) is a polyphenolic natural product widely distributed in food, beverage, and traditional Chinese herbs with beneficial effects on the ca... |
PMC6512037 | core_pubmed_pmc | Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method | Evaluation of the Effects of Astragalus membranaceus on the Pharmacokinetics of Pemetrexed Disodium and Gemcitabine in Rats by a Simple High-Performance Liquid Chromatography/UV Method Abstract Abstract Combination therapy is opted as a potential therapeutic strategy for cancer treatment. Astragalus membranaceus combin... |
PMC12816657 | core_pubmed_pmc | Hyaluronic acid capped cubosomes co-loaded with antitumor agents towards the treatment of colorectal cancer | Hyaluronic acid capped cubosomes co-loaded with antitumor agents towards the treatment of colorectal cancer Abstract Abstract Colorectal cancer (CRC) is the 3rd most lethal type of cancer-linked deaths worldwide. Combination chemotherapy offers a better therapeutic response against CRC than single drug therapy. The pur... |
PMC8391092 | core_pubmed_pmc | Effect of Obesity on Clinical Failure of Patients Treated With β-Lactams | Effect of Obesity on Clinical Failure of Patients Treated With β-Lactams Abstract Abstract Background Altered pharmacokinetics in obese patients raise concerns over worse clinical outcomes. This study assessed whether obese patients receiving a β-lactam have worse clinical outcomes compared to nonobese patients and to ... |
PMC5104339 | core_pubmed_pmc | Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates | Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates Abstract The coformulation of the nucleos(t)ide analogs (NA) tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC) is approved for HIV-infection treatment and prevention. Plasma TFV and FTC undergo complicated ... |
PMC5833774 | core_pubmed_pmc | Pharmacokinetics, distribution and anti-tumor efficacy of liposomal mitoxantrone modified with a luteinizing hormone-releasing hormone receptor-specific peptide | Pharmacokinetics, distribution and anti-tumor efficacy of liposomal mitoxantrone modified with a luteinizing hormone-releasing hormone receptor-specific peptide Abstract Abstract Background A previous study developed a novel luteinizing hormone-releasing hormone (LHRH) receptor-targeted liposome. The aim of this study ... |
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