id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC6590358 | core_pubmed_pmc | Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning | Systemic Tofacitinib Concentrations in Adult Patients With Atopic Dermatitis Treated With 2% Tofacitinib Ointment and Application to Pediatric Study Planning Abstract Abstract Atopic dermatitis is a chronic eczematous, pruritic, inflammatory skin condition affecting children and adults. Tofacitinib is a Janus kinase in... |
PMC10974694 | core_pubmed_pmc | Safety, pharmacokinetics, and pharmacodynamics of anti‐IL‐4Rα antibody SHR ‐1819 in healthy subjects: A randomized, controlled phase I study | Safety, pharmacokinetics, and pharmacodynamics of anti‐IL‐4Rα antibody SHR ‐1819 in healthy subjects: A randomized, controlled phase I study Abstract Abstract SHR‐1819 is a novel anti‐IL‐4Rα monoclonal antibody currently under clinical development for use in patients with type 2 inflammatory diseases. In this randomize... |
PMC9469698 | core_pubmed_pmc | A population PK–PD model of YH4808, a novel P‐CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808 | A population PK–PD model of YH4808, a novel P‐CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808 Abstract Abstract YH4808 is a novel potassium‐competitive acid blocker that is under clinical development to treat patients with gastroesophageal r... |
PMC10145512 | core_pubmed_pmc | A Systematic Review of Clinical Pharmacokinetics of Inhaled Antiviral | A Systematic Review of Clinical Pharmacokinetics of Inhaled Antiviral Abstract Abstract Background and Objectives : The study of clinical pharmacokinetics of inhaled antivirals is particularly important as it helps one to understand the therapeutic efficacy of these drugs and how best to use them in the treatment of re... |
PMC9219807 | core_pubmed_pmc | A Simple Method for the Prediction of Human Concentration–Time Profiles and Pharmacokinetics of Antibody–Drug Conjugates (ADC) from Rats or Monkeys | A Simple Method for the Prediction of Human Concentration–Time Profiles and Pharmacokinetics of Antibody–Drug Conjugates (ADC) from Rats or Monkeys Abstract Abstract Knowledge of human concentration–time profiles from animal data can be useful during early drug development. The objective of this study is to predict hum... |
PMC8377511 | core_pubmed_pmc | Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects | Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects Abstract Background: RT234 (vardenafil inhalation powder) is being developed for pulmonary administration “as needed”, to acutely improve exercise tolerance... |
PMC7036132 | core_pubmed_pmc | Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract | Effects of the Salt-Processing Method on the Pharmacokinetics and Tissue Distribution of Orally Administered Morinda officinalis How. Extract Abstract Abstract Salt processing, which involves steaming with salt water, directs herbs into the kidney channel. After being salt processed, kidney invigorating effects occur. ... |
PMC9965536 | core_pubmed_pmc | Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254) | Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254) Abstract Abstract A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic... |
PMC4460031 | core_pubmed_pmc | Nevirapine Concentration in Hair Samples Is a Strong Predictor of Virologic Suppression in a Prospective Cohort of HIV-Infected Patients | Nevirapine Concentration in Hair Samples Is a Strong Predictor of Virologic Suppression in a Prospective Cohort of HIV-Infected Patients Abstract Effective antiretroviral (ARV) therapy depends on adequate drug exposure, yet methods to assess ARV exposure are limited. Concentrations of ARV in hair are the product of ste... |
PMC3728816 | core_pubmed_pmc | Vasopressin vs Terlipressin in Treatment of Refractory Shock | Vasopressin vs Terlipressin in Treatment of Refractory Shock Abstract Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Recent clinical data suggest that early... |
PMC4531525 | core_pubmed_pmc | Pharmacokinetics of fluticasone furoate, umeclidinium, and vilanterol as a triple therapy in healthy volunteers | Pharmacokinetics of fluticasone furoate, umeclidinium, and vilanterol as a triple therapy in healthy volunteers Abstract Abstract Objective: Two single-center, four-way, single-dose, crossover studies assessed the systemic exposure, systemic pharmacodynamics (PD), and safety profile of the closed triple fluticasone fur... |
PMC12660201 | core_pubmed_pmc | Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation | Morusin as a drug candidate: opportunities, limitations, and the path toward clinical translation Abstract Prenylflavonoids are widespread in plants, which are considered valuable sources of natural polyphenolic compounds with isoprenyl groups, including flavones, flavanones, chalcones and aurones. Among the notable pr... |
PMC10943695 | core_pubmed_pmc | Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment | Neutrophil elastase as a versatile cleavage enzyme for activation of αvβ3 integrin-targeted small molecule drug conjugates with different payload classes in the tumor microenvironment Abstract Abstract Introduction: The development of bioconjugates for the targeted delivery of anticancer agents is gaining momentum afte... |
PMC11662891 | core_pubmed_pmc | Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics | Retention of indoxyl sulfate in different genotypes of ABCC2 may explain variation in tacrolimus pharmacokinetics Abstract Abstract Background Microbiota-derived toxins indoxyl sulfate and hippuric acid were previously reported to be associated with altered pharmacokinetics of the immunosuppressant tacrolimus in liver ... |
PMC10005075 | core_pubmed_pmc | Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer’s Disease in Rats by LC-MS/MS | Study on Absorption, Distribution and Excretion of a New Candidate Compound XYY-CP1106 against Alzheimer’s Disease in Rats by LC-MS/MS Abstract XYY-CP1106, a candidate compound synthesized from a hybrid of hydroxypyridinone and coumarin, has been shown to be remarkably effective in treating Alzheimer’s disease. A simpl... |
PMC7902330 | core_pubmed_pmc | Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats | Pharmacokinetic study of traditional Japanese Kampo medicine shimotsuto used to treat gynecological diseases in rats Abstract Abstract Shimotsuto is a traditional Japanese Kampo medicine used to treat gynecological diseases, such as irregular menstruation, in addition to oversensitivity to cold and chilblains. Part of ... |
PMC9772935 | core_pubmed_pmc | Clinical Impact of Melphalan Pharmacokinetics on Transplantation Outcomes in Children Undergoing Hematopoietic Stem Cell Transplantation | Clinical Impact of Melphalan Pharmacokinetics on Transplantation Outcomes in Children Undergoing Hematopoietic Stem Cell Transplantation Abstract Melphalan is widely used for hematopoietic stem cell transplantation (HSCT) conditioning. However, the relationship between its pharmacokinetic (PK) and transplantation outco... |
PMC3857037 | core_pubmed_pmc | Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults | Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults Abstract Abstract Many physiologic differences between children and adults may result in age-related changes in pharmacokinetics and pharmacodynamics. Factors such as gastric pH and emptying time, intestinal transit time, imm... |
PMC10383245 | core_pubmed_pmc | Transdermal Flunixin Meglumine as a Pain Relief in Donkeys: A Pharmacokinetics Pilot Study | Transdermal Flunixin Meglumine as a Pain Relief in Donkeys: A Pharmacokinetics Pilot Study Abstract Recent approval of transdermal flunixin meglumine (FM) (Banamine ® ) in cattle has opened the door for the drug’s potential application in other species. Transdermal FM could provide a safe and effective form of pain rel... |
PMC11770821 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial | Pharmacokinetics and pharmacodynamics of an innovative psychedelic N,N-dimethyltryptamine/harmine formulation in healthy participants: a randomized controlled trial Abstract Abstract Background Recent interest in the clinical use of psychedelics has highlighted plant-derived medicines like ayahuasca showing rapid-actin... |
PMC7393820 | core_pubmed_pmc | Machine learning reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis | Machine learning reveals that Mycobacterium tuberculosis genotypes and anatomic disease site impacts drug resistance and disease transmission among patients with proven extra-pulmonary tuberculosis Abstract Abstract Background There is a general dearth of information on extrapulmonary tuberculosis (EPTB). Here, we inve... |
PMC12315901 | core_pubmed_pmc | Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats | Safety Profile of Intravenous Ferulic Acid Nanoparticles: Acute Toxicity and Neurological Effects in Sprague-Dawley Rats Abstract Abstract Background Ferulic acid (FA) exhibits therapeutic potential for various disorders, but its clinical application is hindered by poor bioavailability and solubility. This study aimed ... |
PMC6192681 | core_pubmed_pmc | An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse | An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse Abstract Abstract Tobacco use disorder is the leading cause of disease and preventable death worldwide, but current medications that are based on pharmacodynamics have low efficacy. Novel pharmacokinetic approache... |
PMC6146116 | core_pubmed_pmc | SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases | SMMDB: a web-accessible database for small molecule modulators and their targets involved in neurological diseases Abstract Abstract High-throughput screening and better understanding of small molecule’s structure–activity relationship (SAR) using computational biology techniques have greatly expanded the face of drug ... |
PMC7211195 | core_pubmed_pmc | The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid | The influence of the coadministration of the p-glycoprotein modulator elacridar on the pharmacokinetics of lapatinib and its distribution in the brain and cerebrospinal fluid Abstract Summary Background Lapatinib is a small-molecule tyrosine kinase inhibitor of human epidermal receptor 2 (HER2) and EGFR that has curren... |
PMC10354316 | core_pubmed_pmc | Rationale and evidence for the use of new beta-lactam/beta-lactamase inhibitor combinations and cefiderocol in critically ill patients | Rationale and evidence for the use of new beta-lactam/beta-lactamase inhibitor combinations and cefiderocol in critically ill patients Abstract Background Healthcare-associated infections involving Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) phenotype are associated with impaired patient-cente... |
PMC12018549 | core_pubmed_pmc | Exposure–response relationship of niraparib in maintenance therapy for recurrent ovarian cancer: ancillary analysis of the French GINECO–NiQoLe study | Exposure–response relationship of niraparib in maintenance therapy for recurrent ovarian cancer: ancillary analysis of the French GINECO–NiQoLe study Abstract Abstract Background Interindividual variability in pharmacokinetics may influence clinical outcomes of niraparib in patients with platinum-sensitive recurrent ov... |
PMC12737763 | core_pubmed_pmc | Precision Glyco-Modulation of Macrophages with EF-M2 (Immutalon TM ) Improves Function and Lowers Inflammatory Biomarkers in Aging Dogs: A Double-Blind, Placebo-Controlled Trial | Precision Glyco-Modulation of Macrophages with EF-M2 (Immutalon TM ) Improves Function and Lowers Inflammatory Biomarkers in Aging Dogs: A Double-Blind, Placebo-Controlled Trial Abstract Simple Summary Older dogs often slow down and lose “vitality” because of low-grade, chronic inflammation. EF-M2 is a protein-based tr... |
PMC6220428 | core_pubmed_pmc | Dolutegravir/rilpivirine for the treatment of HIV-1 infection | Dolutegravir/rilpivirine for the treatment of HIV-1 infection Abstract Abstract Much progress has been made in the development of antiretroviral therapies (ARTs) for HIV-1 infection. Beginning a little over a decade ago, single tablet combination regimens (STRs) became available, and subsequently, newer STR formulation... |
PMC8550862 | core_pubmed_pmc | OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma | OATP1B1 Plays an Important Role in the Transport and Treatment Efficacy of Sorafenib in Hepatocellular Carcinoma Abstract Background Sorafenib is an anticancer drug used in the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It is a substrate for the human OATP1B1. This study is ai... |
PMC12069994 | core_pubmed_pmc | Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study | Effect of ABCB1 SNP polymorphisms on the plasma concentrations and clinical outcomes of rivaroxaban in Chinese NVAF patients: a population pharmacokinetic-based study Abstract Abstract Background This study utilized a population pharmacokinetic (PPK) approach to assess the influence of ABCB1 genetic polymorphisms on th... |
PMC10099546 | core_pubmed_pmc | Population Pharmacokinetics of Tenecteplase in Patients With Acute Myocardial Infarction and Application to Patients With Acute Ischemic Stroke | Population Pharmacokinetics of Tenecteplase in Patients With Acute Myocardial Infarction and Application to Patients With Acute Ischemic Stroke Abstract Abstract The pharmacokinetics (PK) of tenecteplase in patients with acute ischemic stroke has not been extensively studied. This study aimed to describe PK characteris... |
PMC5121396 | core_pubmed_pmc | Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure | Xpert MTB/RIF Assay Shows Faster Clearance of Mycobacterium tuberculosis DNA with Higher Levels of Rifapentine Exposure Abstract Abstract The Xpert MTB/RIF assay is both sensitive and specific as a diagnostic test. Xpert also reports quantitative output in cycle threshold ( C T ) values, which may provide a dynamic mea... |
PMC9784628 | core_pubmed_pmc | Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide | Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide Abstract Abstract Tacrolimus (Tac) is a pivotal immunosuppressant agent used to prevent graft-versus-host disease (GV... |
PMC7719391 | core_pubmed_pmc | Dose‐Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men | Dose‐Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men Abstract Abstract The rapamycin analogue everolimus (EVR) is a potent inhibitor of the mammalian target of rapamycin (mTOR) and clinically used to prevent allograft rejections as well a... |
PMC11835429 | core_pubmed_pmc | Population Pharmacokinetic/Pharmacodynamic and Exposure‐Response Modeling Analyses of Sotatercept in Healthy Participants and Patients with Pulmonary Arterial Hypertension | Population Pharmacokinetic/Pharmacodynamic and Exposure‐Response Modeling Analyses of Sotatercept in Healthy Participants and Patients with Pulmonary Arterial Hypertension Abstract Sotatercept is a breakthrough, first‐in‐class biologic, recently approved by the Food and Drug Administration (FDA) for the treatment of pu... |
PMC10630019 | core_pubmed_pmc | A Systematic Review of Phytochemistry, Nutritional Composition, and Pharmacologic Application of Species of the Genus Viola in Noncommunicable Diseases (NCDs) | A Systematic Review of Phytochemistry, Nutritional Composition, and Pharmacologic Application of Species of the Genus Viola in Noncommunicable Diseases (NCDs) Abstract Viola L. is the largest genus of the Violaceae family with more than 500 species across the globe. The present extensive literature survey revealed Viol... |
PMC7183808 | core_pubmed_pmc | Omadacycline as a promising new agent for the treatment of infections with Mycobacterium abscessus | Omadacycline as a promising new agent for the treatment of infections with Mycobacterium abscessus Abstract Abstract Background Despite intensive treatment regimens, the outcome of Mycobacterium abscessus infections is extremely poor and thus novel treatment regimens are needed. Although tigecycline seems to be one of ... |
PMC8664670 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of Desmoteplase | Clinical Pharmacokinetics and Pharmacodynamics of Desmoteplase Abstract Desmoteplase is a bat ( Desmodus rotundus ) saliva-derived fibrinolytic enzyme resembling a urokinase and tissue plasminogen activator. It is highly dependent on fibrin and has some neuroprotective attributes. Intravenous administration of desmotep... |
PMC6258891 | core_pubmed_pmc | Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia | Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia Abstract Abstract Introduction Solanezumab treatment was previously shown to significantly increase total (bound + unbound) cerebrospinal fluid (CSF) levels of amyloid β (Aβ) 1–40 and Aβ 1–42 in patients with mild to moderate Alzheimer... |
PMC7913839 | core_pubmed_pmc | The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance | The Minimum Inhibitory Concentration of Antibiotics: Methods, Interpretation, Clinical Relevance Abstract Inefficiency of medical therapies used in order to cure patients with bacterial infections requires not only to actively look for new therapeutic strategies but also to carefully select antibiotics based on variety... |
PMC7383501 | core_pubmed_pmc | Pharmacokinetic and dose‐finding studies on efpeglenatide in patients with type 2 diabetes | Pharmacokinetic and dose‐finding studies on efpeglenatide in patients with type 2 diabetes Abstract Abstract Aim To assess the efficacy, safety and pharmacokinetic/pharmacodynamic properties of efpeglenatide, a long‐acting glucagon‐like peptide‐1 receptor agonist, in patients with type 2 diabetes (T2D). Research design... |
PMC4552636 | core_pubmed_pmc | Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites | Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites Abstract Allyl-isothiocyanate (AITC) is an organosulfur phytochemical found in abundance in common cruciferous vegetables such as mustard, wasabi, and cabbage. Although AITC is metabolized primarily through ... |
PMC4284384 | core_pubmed_pmc | Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals | Quantitative Measurement of the Target-Mediated Internalization Kinetics of Biopharmaceuticals Abstract Purpose Measurement of internalization of biopharmaceuticals targeting cell surface proteins can greatly facilitate drug development. The objective of this study was to develop a reliable method for determination of ... |
PMC10398856 | core_pubmed_pmc | Discovery of Hybrid Thiouracil–Coumarin Conjugates as Potential Novel Anti-SARS-CoV-2 Agents Targeting the Virus’s Polymerase “RdRp” as a Confirmed Interacting Biomolecule | Discovery of Hybrid Thiouracil–Coumarin Conjugates as Potential Novel Anti-SARS-CoV-2 Agents Targeting the Virus’s Polymerase “RdRp” as a Confirmed Interacting Biomolecule Abstract The coronavirus (COVID-19) pandemic, along with its various strains, has emerged as a global health crisis that has severely affected human... |
PMC7325314 | core_pubmed_pmc | Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling | Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically‐Based Pharmacokinetic Modeling Abstract Antiretroviral therapy during pregnancy reduces the risk of vertical HIV‐1 transmission. However, drug dosing is challenging as pharmacokinetics (PK) may be ... |
PMC10859324 | core_pubmed_pmc | Obesity: a gender-view | Obesity: a gender-view Abstract Purpose There is a growing awareness of the importance of understanding gender differences in obesity. The aim of this short review was to revise the current evidence on anthropometric characteristics and nutritional and pharmacological aspects of obesity from a gender perspective. Metho... |
PMC4050360 | core_pubmed_pmc | Biological conversion of aripiprazole lauroxil - An N -acyloxymethyl aripiprazole prodrug | Biological conversion of aripiprazole lauroxil - An N -acyloxymethyl aripiprazole prodrug Abstract N -acyloxyalkylation of NH -acidic compounds can be a prodrug approach for e.g. tertiary or some N -heterocyclic amines and secondary amides and have the potential to modify the properties of the parent drug for specific ... |
PMC8257471 | core_pubmed_pmc | Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers | Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers Abstract BACKGROUND: Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exp... |
PMC12574446 | core_pubmed_pmc | Blood Pressure Reduction During Anesthetic Induction with Remimazolam versus Propofol in Elderly Patients: Pharmacodynamic Modeling of Remimazolam | Blood Pressure Reduction During Anesthetic Induction with Remimazolam versus Propofol in Elderly Patients: Pharmacodynamic Modeling of Remimazolam Abstract Purpose Remimazolam, a novel hypnotic agent, has demonstrated superior hemodynamic stability compared with propofol during general anesthesia, particularly in elder... |
PMC10689914 | core_pubmed_pmc | In vitro synergy of the combination of sulbactam-durlobactam and cefepime at clinically relevant concentrations against A. baumannii , P. aeruginosa and Enterobacterales | In vitro synergy of the combination of sulbactam-durlobactam and cefepime at clinically relevant concentrations against A. baumannii , P. aeruginosa and Enterobacterales Abstract Abstract Background Sulbactam-durlobactam is a potent combination active against Acinetobacter baumannii ; however, it lacks activity against... |
PMC10956049 | core_pubmed_pmc | Safety, efficacy, and pharmacokinetics of nirmatrelvir and ritonavir in patients with severe COVID-19 and renal impairment: A case report | Safety, efficacy, and pharmacokinetics of nirmatrelvir and ritonavir in patients with severe COVID-19 and renal impairment: A case report Abstract Nirmatrelvir/ritonavir (N/r) has received emergency use authorization for mild-to-moderate COVID-19 treatment in adult and pediatric patients (aged and weighing at least 12 ... |
PMC8463036 | core_pubmed_pmc | Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings | Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings Abstract ABSTRACT Constant technological advancement enabled the production of therapeutic monoclonal antibodies (mAbs) and will continue to contribute to their rapid expansion. Compared to small-molecule drugs, mAbs have favor... |
PMC7218526 | core_pubmed_pmc | Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy | Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy Abstract Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein o... |
PMC5667771 | core_pubmed_pmc | Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation | Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation Abstract Pyrazinamide is the main driver of sterilizing effect in the standard regimen in adults and older children, and this effect is concentration-dependent. Tuberculosis patients co-infected with human ... |
PMC9836147 | core_pubmed_pmc | Awareness on current status of usage of ritonavir in the management of covid among dental students | Awareness on current status of usage of ritonavir in the management of covid among dental students Abstract Abstract Ritonavir's pharmacodynamics raise questions regarding whether medication concentrations high enough to block the SARS-CoV-2 proteases can be obtained. Ritonavir may have a therapeutic benefit at any sta... |
PMC10980240 | core_pubmed_pmc | From Flora to Pharmaceuticals: 100 new additions to angiosperms of Gafargaon subdistrict in Bangladesh and unraveling antidiabetic drug candidates targeting DPP4 through in silico approach | From Flora to Pharmaceuticals: 100 new additions to angiosperms of Gafargaon subdistrict in Bangladesh and unraveling antidiabetic drug candidates targeting DPP4 through in silico approach Abstract Addition to the angiosperm flora provides essential insights into the biodiversity of a region, contributing to ecological... |
PMC10051381 | core_pubmed_pmc | Therapeutic Drug Monitoring of Vedolizumab in Inflammatory Bowel Disease Patients during Maintenance Treatment—TUMMY Study | Therapeutic Drug Monitoring of Vedolizumab in Inflammatory Bowel Disease Patients during Maintenance Treatment—TUMMY Study Abstract Abstract There are limited data on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD) patients treated with vedolizumab (VDZ). Although an exposure–response relation has... |
PMC7670518 | core_pubmed_pmc | Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation | Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel “Cytotopic” Anti‐Thrombin Without Prolonged Anticoagulation Abstract Abstract Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinicall... |
PMC4363860 | core_pubmed_pmc | Sensitization of Gram-negative bacteria to rifampin and OAK combinations | Sensitization of Gram-negative bacteria to rifampin and OAK combinations Abstract While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of one compound have potentiated the other by 2–4 orders of mag... |
PMC11687410 | core_pubmed_pmc | Model‐based interspecies interpretation of botulinum neurotoxin type A on muscle‐contraction inhibition | Model‐based interspecies interpretation of botulinum neurotoxin type A on muscle‐contraction inhibition Abstract Abstract Botulinum neurotoxins (BoNTs) are commonly used in therapeutic and cosmetic applications. One such neurotoxin, BoNT type A (BoNT/A), has been studied widely for its effects on muscle function and co... |
PMC10572397 | core_pubmed_pmc | Effect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects | Effect of Food on the Pharmacokinetics of Tenofovir Amibufenamide: A Phase I, Randomized, Open-Label, Two-Period Crossover Trial in Healthy Adult Subjects Abstract Abstract Purpose Tenofovir amibufenamide (TMF) is a novel nucleotide reverse transcriptase inhibitor. The aim of this study was to investigate the effect of... |
PMC8116206 | core_pubmed_pmc | Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats | Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats Abstract Abstract Alpinia officinarum Hance of the Chinese traditional herb for the treatment of emesis, abdominal pain and dia... |
PMC6598168 | core_pubmed_pmc | Development and validation of an LC-MS/MS method for tyrphostin A9 | Development and validation of an LC-MS/MS method for tyrphostin A9 Abstract Abstract Here we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as ... |
PMC3428318 | core_pubmed_pmc | Pharmacodynamics of Antimicrobials against Mycoplasma mycoides mycoides Small Colony, the Causative Agent of Contagious Bovine Pleuropneumonia | Pharmacodynamics of Antimicrobials against Mycoplasma mycoides mycoides Small Colony, the Causative Agent of Contagious Bovine Pleuropneumonia Abstract Abstract Background Mycoplasma mycoides subspecies mycoides Small Colony ( Mmm SC) is the causative agent of Contagious Bovine Pleuropneumonia (CBPP), a disease of subs... |
PMC4548739 | core_pubmed_pmc | Efficacy and safety of the long-acting β 2 -agonist olodaterol over 4 weeks in Japanese patients with chronic obstructive pulmonary disease | Efficacy and safety of the long-acting β 2 -agonist olodaterol over 4 weeks in Japanese patients with chronic obstructive pulmonary disease Abstract Abstract Background Olodaterol is a novel long-acting β 2 -agonist with proven ≥24-hour duration of action in preclinical and clinical studies. Objective This randomized, ... |
PMC8246766 | core_pubmed_pmc | Pharmacokinetics of Belimumab in Children With Systemic Lupus Erythematosus | Pharmacokinetics of Belimumab in Children With Systemic Lupus Erythematosus Abstract Abstract The phase 2 placebo‐controlled, double‐blind PLUTO trial characterized the pharmacokinetics of belimumab plus standard systemic lupus erythematosus (SLE) therapy in patients with childhood‐onset SLE (cSLE) and demonstrated sim... |
PMC12180593 | core_pubmed_pmc | Model-Informed Precision Dosing of Remimazolam in General Anesthesia Patients | Model-Informed Precision Dosing of Remimazolam in General Anesthesia Patients Abstract Purpose This study aimed to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of remimazolam in patients under general anesthesia using a population analysis and to develop a web-based dashboard tool that directly displays t... |
PMC11089243 | core_pubmed_pmc | The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses | The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses Abstract Abstract Introduction: TT-01025-CL is an oral, irreversible small molecule that potently inhibits vascular adhesion protein-1 (VAP-1) for the treatment... |
PMC11701949 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Neonatal Fc Receptor Inhibitor Rozanolixizumab: An Ethnic Sensitivity Study in Healthy Japanese, Chinese, and White Participants | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Neonatal Fc Receptor Inhibitor Rozanolixizumab: An Ethnic Sensitivity Study in Healthy Japanese, Chinese, and White Participants Abstract Abstract Rozanolixizumab is an anti‐human neonatal Fc receptor humanized immunoglobulin (Ig) G4 monoclonal antibod... |
PMC5321639 | core_pubmed_pmc | Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus | Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus Abstract NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus . Our objective was to identify NZ2114 derivatives wit... |
PMC12304798 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study | Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study Abstract Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors ha... |
PMC11284144 | core_pubmed_pmc | A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects | A phase 1, randomized, double-blind, placebo-controlled, dose escalation study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-1905, a long-acting anti-thymic stromal lymphopoietin antibody, in healthy subjects Abstract Abstract Introduction Thymic stromal lymphopoietin (TSLP) is integr... |
PMC8951011 | core_pubmed_pmc | Effect of Caffeine and Flavonoids on the Binding of Tigecycline to Human Serum Albumin: A Spectroscopic Study and Molecular Docking | Effect of Caffeine and Flavonoids on the Binding of Tigecycline to Human Serum Albumin: A Spectroscopic Study and Molecular Docking Abstract Abstract Human serum albumin (HSA) has a very significant role in the transport of drugs, in their pharmacokinetic and pharmacodynamic properties, as well as the unbound concentra... |
PMC9137536 | core_pubmed_pmc | Drug Regimens of Novel Antibiotics in Critically Ill Patients with Varying Renal Functions: A Rapid Review | Drug Regimens of Novel Antibiotics in Critically Ill Patients with Varying Renal Functions: A Rapid Review Abstract Abstract There is currently an increase in the emergence of multidrug-resistant bacteria (MDR) worldwide, requiring the development of novel antibiotics. However, it is not only the choice of antibiotic t... |
PMC4504870 | core_pubmed_pmc | Absorption, distribution and excretion of intravenously injected 68 Ge/ 68 Ga generator eluate in healthy rats, and estimation of human radiation dosimetry | Absorption, distribution and excretion of intravenously injected 68 Ge/ 68 Ga generator eluate in healthy rats, and estimation of human radiation dosimetry Abstract Abstract Background This study evaluated the absorption, distribution, and excretion of Gallium-68 ( 68 Ga) radionuclide after a single intravenous (i.v.) ... |
PMC8647693 | core_pubmed_pmc | Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration | Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration Abstract Supplemental Digital Content is Available in the Text. Objective: To describe and compare systemic and local pharmacokinetics (PK) and cervicovaginal (CV) pharmacodynamics (PD) ... |
PMC6966182 | core_pubmed_pmc | Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis | Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis Abstract Abstract Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (... |
PMC12902727 | core_pubmed_pmc | Model‐Informed Abatacept Dose Recommendation in Pediatric Patients With Acute Graft Versus Host Disease | Model‐Informed Abatacept Dose Recommendation in Pediatric Patients With Acute Graft Versus Host Disease Abstract Abstract This study uses a population pharmacokinetic (PPK) approach to provide abatacept dosing recommendations in pediatric patients 2 to < 6 years of age receiving unrelated donor hematopoietic stem cell ... |
PMC12495782 | core_pubmed_pmc | Exploratory high-throughput screening of repurposed drugs for canine lymphoid malignancies | Exploratory high-throughput screening of repurposed drugs for canine lymphoid malignancies Abstract Abstract Background Lymphoid malignancies are common in dogs. However, the limitations of existing chemotherapy highlight the need for alternative therapies. Drug repositioning is a promising approach for discovering new... |
PMC5814527 | core_pubmed_pmc | Access to the CNS: Biomarker Strategies for Dopaminergic Treatments | Access to the CNS: Biomarker Strategies for Dopaminergic Treatments Abstract Abstract Despite substantial research carried out over the last decades, it remains difficult to understand the wide range of pharmacological effects of dopaminergic agents. The dopaminergic system is involved in several neurological disorders... |
PMC8793782 | core_pubmed_pmc | Post-hoc Analysis of Pharmacodynamics and Single-Agent Activity of CD3xCD123 Bispecific Antibody APVO436 in Relapsed/Refractory AML and MDS Resistant to HMA or Venetoclax Plus HMA | Post-hoc Analysis of Pharmacodynamics and Single-Agent Activity of CD3xCD123 Bispecific Antibody APVO436 in Relapsed/Refractory AML and MDS Resistant to HMA or Venetoclax Plus HMA Abstract Abstract APVO436 is a recombinant bispecific antibody designed to direct host cytotoxic T-cells to CD123-expressing blast cells in ... |
PMC6714928 | core_pubmed_pmc | Effects of Obesity on Warfarin Reversal With Vitamin K | Effects of Obesity on Warfarin Reversal With Vitamin K Abstract Abstract Phytonadione (vitamin K1, VK) is fat soluble and may be sequestered by adipose tissue, thus potentially altering drug distribution in obese patients requiring warfarin reversal. This single-center retrospective cohort study aimed to determine the ... |
PMC4041784 | core_pubmed_pmc | Stereoselective Property of 20( S )-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein | Stereoselective Property of 20( S )-Protopanaxadiol Ocotillol Type Epimers Affects Its Absorption and Also the Inhibition of P-Glycoprotein Abstract Abstract Stereoselectivity has been proved to be tightly related to drug action including pharmacodynamics and pharmacokinetics. (20S,24R)-epoxy-dammarane-3,12,25-triol (2... |
PMC11868361 | core_pubmed_pmc | Repeated Switching Between CT-P17 and EU Reference Adalimumab in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: A Randomized, Double-Blind, Active-Controlled, Phase 3, Interchangeability Study | Repeated Switching Between CT-P17 and EU Reference Adalimumab in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: A Randomized, Double-Blind, Active-Controlled, Phase 3, Interchangeability Study Abstract Abstract Introduction This study aimed to demonstrate the interchangeability of biosimilar CT-P17 and Euro... |
PMC5799260 | core_pubmed_pmc | Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster | Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster Abstract Abstract Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains ... |
PMC6702932 | core_pubmed_pmc | Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution | Pharmacokinetics of combination antiparasitic drug preparation for dogs and cats in the form of spot-on solution Abstract Abstract Objective: The object of the study was to examine the major pharmacokinetic parameters after a single application of a complex drug preparation for veterinary use based on fipronil, praziqu... |
PMC6617747 | core_pubmed_pmc | Monoclonal Antibodies and Fc‐Fusion Proteins for Pediatric Use: Dosing, Immunogenicity, and Modeling and Simulation in Data Submitted to the US Food and Drug Administration | Monoclonal Antibodies and Fc‐Fusion Proteins for Pediatric Use: Dosing, Immunogenicity, and Modeling and Simulation in Data Submitted to the US Food and Drug Administration Abstract Abstract The experience with the use of monoclonal antibodies and Fc‐fusion proteins (mAb/Fc) in the pediatric population is limited. The ... |
PMC4753396 | core_pubmed_pmc | In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques | In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques Abstract Free radicals, particularly reactive oxygen species (ROS), are involved in various pathologies, injuries related to radiation, ischemia-reperfusion or ageing. Unfortunately... |
PMC12086322 | core_pubmed_pmc | Pharmacodynamic Effect of Different Dosage Regimes of Oseltamivir in Severe Influenza Patients Requiring Mechanical Ventilation: A Multicentre Randomised Controlled Trial | Pharmacodynamic Effect of Different Dosage Regimes of Oseltamivir in Severe Influenza Patients Requiring Mechanical Ventilation: A Multicentre Randomised Controlled Trial Abstract ABSTRACT Background and Objectives This randomised controlled trial evaluated whether higher doses of oseltamivir would improve virological ... |
PMC4492732 | core_pubmed_pmc | The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats | The distribution and clearance of (2S,6S)-hydroxynorketamine, an active ketamine metabolite, in Wistar rats Abstract Abstract The distribution, clearance, and bioavailability of (2S,6S)-hydroxynorketamine has been studied in the Wistar rat. The plasma and brain tissue concentrations over time of (2S,6S)-hydroxynorketam... |
PMC12657313 | core_pubmed_pmc | A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying | A comparison of theacrine and methylliberine with caffeine as salivary markers for determining gastric emptying Abstract Gastric emptying is a critical determinant of the pharmacokinetics of orally administered drugs. A key limitation in studies using caffeine as a marker for gastric emptying is the requirement for pri... |
PMC7356959 | core_pubmed_pmc | Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs | Quantification of Pharmacokinetic Profiles of PD-1/PD-L1 Antibodies by Validated ELISAs Abstract Abstract Immunotherapy has changed the paradigm of cancer treatments. In this way, several combinatorial strategies based on monoclonal antibodies (mAb) such as anti (a)-PD-1 or anti (a)-PD-L1 are often reported to yield pr... |
PMC3967138 | core_pubmed_pmc | Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients | Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients Abstract Tacrolimus is a calcineurin inhibitor immunosuppressant that has seen considerable use in both adult and pediatric solid organ transplant recipients. Though there is much pharmacokinetic da... |
PMC6789481 | core_pubmed_pmc | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows | A Comparative Pharmacokinetic Analysis of Oral and Subcutaneous Meloxicam Administered to Postpartum Dairy Cows Abstract The dairy industry needs evidence-based solutions to mitigate painful procedures and conditions in dairy cattle. The objective of this study was to compare the pharmacokinetic properties of orally ve... |
PMC8663927 | core_pubmed_pmc | Pharmacokinetic drug interactions of integrase strand transfer inhibitors | Pharmacokinetic drug interactions of integrase strand transfer inhibitors Abstract The integrase strand transfer inhibitor (INSTI)-containing regimens are currently considered as the first-line treatment of human immunodeficiency virus (HIV) infection. Although possessing a common mechanism of action to inhibit HIV int... |
PMC6429202 | core_pubmed_pmc | Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation | Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation Abstract Abstract A small library of new drug-1,3,4-thiazidazole hybrid compounds ( 3a – 3i ) was synthesized, characterized, and assessed for their acetyl choli... |
PMC12566120 | core_pubmed_pmc | In Vitro Metabolism of a Benzofuran-Substituted Nitazene: Ethyleneoxynitazene | In Vitro Metabolism of a Benzofuran-Substituted Nitazene: Ethyleneoxynitazene Abstract Abstract Background/Objectives : New synthetic opioids (NSOs) like nitazenes pose significant public health risks due to their high potency and increasing prevalence. Ethyleneoxynitazene, a benzofuran-containing nitazene, recently em... |
PMC9292591 | core_pubmed_pmc | Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation | Assessment of the safe and efficacious dose of the selective progesterone receptor modulator vilaprisan for the treatment of patients with uterine fibroids by exposure–response modelling and simulation Abstract Aims We report population pharmacokinetic (popPK) and exposure–response (E–R) analyses for efficacy (induced ... |
PMC9434412 | core_pubmed_pmc | Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors | Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors Abstract Abstract Background Activation of leukemia inhibitory factor (LIF) is linked to an immunosuppressive tumor microenvironment (TME), with a strong association between LIF e... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.