id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC8143174 | core_pubmed_pmc | Laboratory Monitoring of Direct Oral Anticoagulants (DOACs) | Laboratory Monitoring of Direct Oral Anticoagulants (DOACs) Abstract The introduction of direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban, provides safe and effective alternative to previous anticoagulant therapies. DOACs directly, selectively, and reversibly inhib... |
PMC6810667 | core_pubmed_pmc | Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam | Higher MICs (>2 mg/L) Predict 30-Day Mortality in Patients With Lower Respiratory Tract Infections Caused by Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa Treated With Ceftolozane/Tazobactam Abstract Abstract Background Ceftolozane/tazobactam (C/T) efficacy and safety in ventilator-associated pneumon... |
PMC6819847 | core_pubmed_pmc | Computational and spectral studies of 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) | Computational and spectral studies of 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one) Abstract Detection and qualification of unknown impurities during commercial drug synthesis have been mandated by the regulatory authorities. 3,3'-(propane-1,3-diyl)bis(7,8-dimethoxy-1,3,4,5-tetrah... |
PMC11872518 | core_pubmed_pmc | Palbociclib exposure in relation to efficacy and toxicity in patients with advanced breast cancer | Palbociclib exposure in relation to efficacy and toxicity in patients with advanced breast cancer Abstract Abstract Background Data on exposure–response or exposure–toxicity relationships of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are limited and inconclusive. We aimed to investigate whether there is an associ... |
PMC11678214 | core_pubmed_pmc | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics | Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics Abstract Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effectiv... |
PMC5315738 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of Afatinib | Clinical Pharmacokinetics and Pharmacodynamics of Afatinib Abstract Afatinib is an oral, irreversible ErbB family blocker that covalently binds to the kinase domains of epidermal growth factor receptor (EGFR), human EGFRs (HER) 2, and HER4, resulting in irreversible inhibition of tyrosine kinase autophosphorylation. St... |
PMC11500426 | core_pubmed_pmc | Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans | Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans Abstract Abstract Chlorinated polyfluorinated ether sulfonic acid (F-53B), a commonly utilized alternative for perfluorooctane sulfonate, was detected in pregnant women and cord blood recently.... |
PMC9909267 | core_pubmed_pmc | Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience | Multicenter review of a tadalafil suspension formulation for infants and children with pulmonary hypertension: A North American experience Abstract Introduction Phosphodiesterase type 5 (PDE5) inhibitors, with sildenafil the earliest among them, are widely used in the management of pediatric pulmonary arterial hyperten... |
PMC11742092 | core_pubmed_pmc | UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research | UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research Abstract Abstract Background Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma. Purpose This study ai... |
PMC7383509 | core_pubmed_pmc | The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine | The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Oliceridine Abstract Abstract Oliceridine is a G protein–biased ligand at the μ‐opioid receptor in development for treatment of moderate to severe acute pain. A phase 1, open‐label, single‐dose study investigated the pharm... |
PMC12383002 | core_pubmed_pmc | Ceftazidime–Avibactam in Critically Ill Patients: A Multicenter Observational Study | Ceftazidime–Avibactam in Critically Ill Patients: A Multicenter Observational Study Abstract Abstract Ceftazidime–avibactam (CAZ-AVI) is a second-generation intravenous β-lactam/β-lactamase inhibitor combination. In recent years, substantial evidence has emerged regarding the efficacy and safety of CAZ-AVI. However, da... |
PMC7993283 | core_pubmed_pmc | Effect of Crohn’s Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine | Effect of Crohn’s Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine Abstract Changes in absorptive capacity and first‐pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing phys... |
PMC10098839 | core_pubmed_pmc | Single‐dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs | Single‐dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs Abstract Abstract Telmisartan is an angiotensin II receptor blocker that has great potential to improve the treatment of hypertension, proteinuria, and cardiovascular disease in dogs. A feline‐approved telmisartan oral solution (TOS... |
PMC6048694 | core_pubmed_pmc | Knowledge is power: general practitioners prescribing of new oral anticoagulants in Ireland | Knowledge is power: general practitioners prescribing of new oral anticoagulants in Ireland Abstract Abstract Objective New oral anticoagulants (NOACs) aim to overcome warfarin’s shortcomings, however their pharmacokinetic characteristics make prescribing complex. Thus it is imperative that general practitioners (GPs) ... |
PMC3927193 | core_pubmed_pmc | Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure | Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure Abstract Abstract Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse e... |
PMC4478358 | core_pubmed_pmc | L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson's Disease: A Randomised Study | L-Dopa Pharmacokinetic Profile with Effervescent Melevodopa/Carbidopa versus Standard-Release Levodopa/Carbidopa Tablets in Parkinson's Disease: A Randomised Study Abstract Abstract Objectives. To characterize the pharmacokinetic profile of levodopa (L-dopa) and carbidopa after repeated doses of the effervescent tablet... |
PMC10975701 | core_pubmed_pmc | PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy | PK Modeling of L-4-Boronophenylalanine and Development of Bayesian Predictive Platform for L-4-Boronophenylalanine PKs for Boron Neutron Capture Therapy Abstract Abstract L-4-[( 10 B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron c... |
PMC6141109 | core_pubmed_pmc | Pharmacokinetics of evocalcet in secondary hyperparathyroidism patients receiving hemodialysis: first-in-patient clinical trial in Japan | Pharmacokinetics of evocalcet in secondary hyperparathyroidism patients receiving hemodialysis: first-in-patient clinical trial in Japan Abstract Abstract Purpose Cinacalcet is a positive allosteric modulator of calcium-sensing receptors in the parathyroid gland and an effective treatment for secondary hyperparathyroid... |
PMC6035379 | core_pubmed_pmc | Effect of Korean Red Ginseng extracts on drug-drug interactions | Effect of Korean Red Ginseng extracts on drug-drug interactions Abstract Abstract Background Ginseng has been the subject of many experimental and clinical studies to uncover the diverse biological activities of its constituent compounds. It is a traditional medicine that has been used for its immunostimulatory, antith... |
PMC9695321 | core_pubmed_pmc | Aptamer-Based Probes for Cancer Diagnostics and Treatment | Aptamer-Based Probes for Cancer Diagnostics and Treatment Abstract Abstract Aptamers are single-stranded DNA or RNA oligomers that have the ability to generate unique and diverse tertiary structures that bind to cognate molecules with high specificity. In recent years, aptamer researches have witnessed a huge surge, ow... |
PMC11434876 | core_pubmed_pmc | Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians | Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians Abstract Abstract Prevention, assessment, and identification of drug–drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessme... |
PMC12786445 | core_pubmed_pmc | Discovering the Anti-Inflammatory Potential of Compounds Isolated from the Aerial Parts of Gelasia tomentosa (L.) Zaika, Sukhor. & N.Kilian (Syn. Scorzonera tomentosa ), Through In Vitro Techniques and Advanced In Silico Modeling Approaches | Discovering the Anti-Inflammatory Potential of Compounds Isolated from the Aerial Parts of Gelasia tomentosa (L.) Zaika, Sukhor. & N.Kilian (Syn. Scorzonera tomentosa ), Through In Vitro Techniques and Advanced In Silico Modeling Approaches Abstract Abstract Gelasia tomentosa (L.) Zaika, Sukhor. & N.Kilian which is kno... |
PMC7070709 | core_pubmed_pmc | Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease | Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Abstract A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic ... |
PMC12256768 | core_pubmed_pmc | Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification | Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification Abstract Abstract Background The relationship between an elevated triglyceride-glucose index (TyG) combined with intracranial arterial stenosis (ICAS) and stroke recu... |
PMC4425807 | core_pubmed_pmc | Investigating interactions between phentermine, dexfenfluramine, and 5-HT 2C agonists, on food intake in the rat | Investigating interactions between phentermine, dexfenfluramine, and 5-HT 2C agonists, on food intake in the rat Abstract Rationale Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT 2C antagon... |
PMC3969253 | core_pubmed_pmc | In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions | In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions Abstract P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from mammalian c... |
PMC9045709 | core_pubmed_pmc | The Efficacy of a Didactic and Case-Based Pharmacogenomics Education Program on Improving the Knowledge and Confidence of Alberta Pharmacists | The Efficacy of a Didactic and Case-Based Pharmacogenomics Education Program on Improving the Knowledge and Confidence of Alberta Pharmacists Abstract Background Pharmacogenomics (PGx) is the study of how genetic variations for functional proteins, such as metabolizing enzymes and drug receptors, impact drug pharmacoki... |
PMC7894397 | core_pubmed_pmc | A population pharmacokinetics analysis assessing the exposure of raltegravir once‐daily 1200 mg in pregnant women living with HIV | A population pharmacokinetics analysis assessing the exposure of raltegravir once‐daily 1200 mg in pregnant women living with HIV Abstract Abstract Once‐daily two 600 mg tablets (1200 mg q.d.) raltegravir offers an easier treatment option compared to the twice‐daily regimen of one 400 mg tablet. No pharmacokinetic, eff... |
PMC5677780 | core_pubmed_pmc | Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse | Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse Abstract Abstract The aims of this study were to assess the plasma concentrations of romifidine in horses after intravenous injection, to evaluate the red blood cell ( RBC ) partitioning of the... |
PMC6469740 | core_pubmed_pmc | Objective measures of non-adherence in cardiometabolic diseases: a review focused on urine biochemical screening | Objective measures of non-adherence in cardiometabolic diseases: a review focused on urine biochemical screening Abstract Abstract Cardiometabolic diseases are among the most prevalent and harmful conditions worldwide. They are complex, comorbid conditions that require polypharmacy – a known contributor to non-adherenc... |
PMC6521709 | core_pubmed_pmc | Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis -infected BALB/c mice | Pharmacokinetics of neutron-irradiated meglumine antimoniate in Leishmania amazonensis -infected BALB/c mice Abstract Abstract Background: Cutaneous leishmaniasis (CL) is a parasitic disease caused by the protozoan Leishmania spp. Pentavalent antimonial agents have been used as an effective therapy, despite their side ... |
PMC12559684 | core_pubmed_pmc | Repurposing Existing Drugs for the Treatment of Post-Traumatic Stress Disorder | Repurposing Existing Drugs for the Treatment of Post-Traumatic Stress Disorder Abstract Abstract Chronic stress and traumatic events affect the psychological and physiological state of a person. Post-traumatic stress disorder (PTSD) is a type of psychological stress that occurs in critical situations that pose a direct... |
PMC6611588 | core_pubmed_pmc | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors Abstract CD47 is an immune checkpoint molecule that downregulates key aspects of both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα, and it is expressed at high levels... |
PMC10386912 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide | Clinical Pharmacokinetics and Pharmacodynamics of the Next Generation Androgen Receptor Inhibitor—Darolutamide Abstract Abstract Darolutamide is a next-generation androgen receptor signaling inhibitor (ARSI) currently approved for the treatment of nonmetastatic castration-resistant prostate cancer (nmCRPC) and metastat... |
PMC9411058 | core_pubmed_pmc | Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia | Pharmacometric approach to assist dosage regimen design in neonates undergoing therapeutic hypothermia Abstract Background Therapeutic hypothermia (TH) is the treatment of choice for neonates diagnosed with perinatal asphyxia (PA). Dosing recommendations of various therapeutic agents including antimicrobials were not s... |
PMC7071312 | core_pubmed_pmc | Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals | Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals Abstract Plasma vitamin C concentrations fluctuate in response to recent dietary intake; therefore levels are typically determined in the fasting state. Erythrocyte ascorbate concentrations ... |
PMC4622731 | core_pubmed_pmc | Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig TM ) molecule that specifically and potently neutralizes both IL-1α and IL-1β | Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig TM ) molecule that specifically and potently neutralizes both IL-1α and IL-1β Abstract Interleukin-1 (IL-1) cytokines such as IL-1α, IL-1β, and IL-1Ra contribute to immune regulation and inflammatory processes by exerting a wide r... |
PMC6977279 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer’s disease | Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer’s disease Abstract Background Crenezumab, a fully humanized anti-beta-amyloid (Aβ) immunoglobulin G4 (IgG4) monoclonal antibody, binds to both monomeric and aggregated for... |
PMC9821414 | core_pubmed_pmc | Drug-drug interaction and acute kidney injury development: A correlation-based network analysis | Drug-drug interaction and acute kidney injury development: A correlation-based network analysis Abstract Abstract Background Drug-induced nephrotoxicity is a relatively common preventable cause of acute kidney injury (AKI), providing early recognition and management. The pharmacokinetics or pharmacodynamics of drug-dru... |
PMC10328871 | core_pubmed_pmc | Safety, Tolerability, and Pharmacokinetics of Recombinant Human Neuregulin-1 in Healthy Chinese Subjects | Safety, Tolerability, and Pharmacokinetics of Recombinant Human Neuregulin-1 in Healthy Chinese Subjects Abstract Abstract Background We investigated the safety, tolerability, and pharmacokinetics of intravenous recombinant human Neuregulin-1 (rhNRG-1), a DNA recombinant protein for the treatment of chronic heart failu... |
PMC7586797 | core_pubmed_pmc | Phase 1 Study to Evaluate the Effect of the Investigational Anticancer Agent Sapanisertib on the QTc Interval in Patients With Advanced Solid Tumors | Phase 1 Study to Evaluate the Effect of the Investigational Anticancer Agent Sapanisertib on the QTc Interval in Patients With Advanced Solid Tumors Abstract Abstract The aim of this phase 1 study was to determine the effects of sapanisertib on the heart rate–corrected QT (QTc) interval in patients with advanced solid ... |
PMC6104801 | core_pubmed_pmc | Development of a population pharmacokinetic model of olanzapine for Chinese health volunteers and patients with schizophrenia | Development of a population pharmacokinetic model of olanzapine for Chinese health volunteers and patients with schizophrenia Abstract Objective Olanzapine is an atypical antipsychotic drug commonly used for the treatment of schizophrenia. However, there are still many complications associated with the use of olanzapin... |
PMC10187793 | core_pubmed_pmc | Corticosteroid–Antibiotic Interactions in Bacteria that Cause Corneal Infection | Corticosteroid–Antibiotic Interactions in Bacteria that Cause Corneal Infection Abstract Abstract Purpose Although a comprehensive knowledge of antibiotic/corticosteroid combinations is essential for the appropriate treatment of eye infections, the impact of their co-administration has not been well studied to date. A ... |
PMC9891290 | core_pubmed_pmc | Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents | Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents Abstract Background: During long-term antiplatelet agents (APAs) administration, patients with thrombotic diseases take a fairly high risk of life-threatening bleeding, especially when in need of urgent surgery. Rapid functional reversal of A... |
PMC10819729 | core_pubmed_pmc | Systemic and Brain Pharmacokinetics of Milnacipran in Mice: Comparison of Intraperitoneal and Intravenous Administration | Systemic and Brain Pharmacokinetics of Milnacipran in Mice: Comparison of Intraperitoneal and Intravenous Administration Abstract Milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the treatment of major depression or fibromyalgia. Currently, there are no studies reporting the ph... |
PMC7533164 | core_pubmed_pmc | Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling | Qualification and application of liquid chromatography-quadrupole time-of-flight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling Abstract Abstract Carisbamate is an antiepileptic drug and it al... |
PMC12575765 | core_pubmed_pmc | Synergistic effects of colistin-based combinations against colistin and carbapenem-resistant Klebsiella pneumoniae isolated from nosocomial bloodstream infections | Synergistic effects of colistin-based combinations against colistin and carbapenem-resistant Klebsiella pneumoniae isolated from nosocomial bloodstream infections Abstract The emergence of colistin and carbapenem-resistant Klebsiella pneumoniae (CRCR-KP) poses a critical challenge in treating bloodstream infections. As... |
PMC12030428 | core_pubmed_pmc | Pharmacokinetics of Psilocybin: A Systematic Review | Pharmacokinetics of Psilocybin: A Systematic Review Abstract Abstract Background: Psilocybin has shown promise in therapeutic applications for mental disorders. Understanding the pharmacokinetics of psilocybin and its active metabolite psilocin is crucial for optimizing its clinical use and minimizing adverse effects. ... |
PMC6451721 | core_pubmed_pmc | Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation | Population Pharmacokinetics of Fludarabine in Children and Adults during Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation Abstract Background Fludarabine is often used as an important drug in reduced toxicity conditioning regimens prior to hematopoietic cell transplantation (HCT). As no definitive ph... |
PMC9897045 | core_pubmed_pmc | Novel Investigational Anti-SARS-CoV-2 Agent Ensitrelvir “S-217622”: A Very Promising Potential Universal Broad-Spectrum Antiviral at the Therapeutic Frontline of Coronavirus Species | Novel Investigational Anti-SARS-CoV-2 Agent Ensitrelvir “S-217622”: A Very Promising Potential Universal Broad-Spectrum Antiviral at the Therapeutic Frontline of Coronavirus Species Abstract Abstract Lately, nitrogenous heterocyclic antivirals, such as nucleoside-like compounds, oxadiazoles, thiadiazoles, triazoles, qu... |
PMC12702981 | core_pubmed_pmc | Population pharmacokinetics of efpeglenatide in individuals with obesity and with type 2 diabetes | Population pharmacokinetics of efpeglenatide in individuals with obesity and with type 2 diabetes Abstract Background Efpeglenatide (HM11260C) is a long-acting GLP-1 receptor agonist under development for obesity. A population pharmacokinetic (PK) analysis was conducted to characterize its PK properties and evaluate co... |
PMC9866629 | core_pubmed_pmc | Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model | Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model Abstract Abstract Novel furoxan/coumarin hybrids were synthesized, and pharmacologic studies showed that the compounds displayed potent antiproliferation activities via downregulating both th... |
PMC7300220 | core_pubmed_pmc | Initial Dosage Recommendation for Sirolimus in Children With Tuberous Sclerosis Complex | Initial Dosage Recommendation for Sirolimus in Children With Tuberous Sclerosis Complex Abstract Sirolimus is already used in the treatment of tuberous sclerosis complex (TSC), however, with narrow therapeutic range and considerable inter- and intra-individual pharmacokinetic variability, making it hard to develop an a... |
PMC8443776 | core_pubmed_pmc | Population Pharmacokinetics of Rituximab in Pediatric Patients With Frequent-Relapsing or Steroid-Dependent Nephrotic Syndrome | Population Pharmacokinetics of Rituximab in Pediatric Patients With Frequent-Relapsing or Steroid-Dependent Nephrotic Syndrome Abstract Abstract Objectives: Rituximab is frequently used off-label for the treatment of frequent-relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS), but the re... |
PMC11843070 | core_pubmed_pmc | Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit | Correlations of vancomycin trough concentration and its efficacy and toxicity in patients in the intensive care unit Abstract BACKGROUND Plasma concentration monitoring is crucial for optimizing vancomycin use, particularly in patients in the intensive care unit (ICU). However, the reference interval for vancomycin pla... |
PMC11192707 | core_pubmed_pmc | BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer | BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer Abstract Background The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positi... |
PMC9840109 | core_pubmed_pmc | Consecutive baicalin treatment relieves its accumulation in rats with intrahepatic cholestasis by increasing MRP2 expression | Consecutive baicalin treatment relieves its accumulation in rats with intrahepatic cholestasis by increasing MRP2 expression Abstract Abstract Baicalin, an important flavonoid isolated from Scutellaria baicalensis Georgi, is a Chinese herb widely used in clinical practice. We previously reported the in vivo accumulatio... |
PMC5856873 | core_pubmed_pmc | A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation | A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation Abstract Background Multiple clinical, demographic, and genetic factors affect the pharmacokinetics of tacrolimus in children, yet in daily practice, a uniform body-weight based starting do... |
PMC8415218 | core_pubmed_pmc | A pharmacokinetics‐based approach to the monitoring of patient adherence to atorvastatin therapy | A pharmacokinetics‐based approach to the monitoring of patient adherence to atorvastatin therapy Abstract Abstract The inadequate adherence of patients whose hyperlipidemia is treated with atorvastatin (ATR) to medical instructions presents a serious health risk. Our aim was to develop a flexible approach based on ther... |
PMC3837842 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization | Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization Abstract Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which were too low, particularly for high-risk groups such as young children and pregnant women. This may accelerate the emergence and... |
PMC5306091 | core_pubmed_pmc | Pharmacokinetic and exposure–response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer | Pharmacokinetic and exposure–response analyses of pertuzumab in combination with trastuzumab and docetaxel during neoadjuvant treatment of HER2+ early breast cancer Abstract Purpose The NeoSphere trial evaluated pertuzumab in the neoadjuvant setting [early breast cancer (EBC)] with pathological complete response (pCR) ... |
PMC5548487 | core_pubmed_pmc | Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets | Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets Abstract Abstract The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a metho... |
PMC5766727 | core_pubmed_pmc | Clinical Pharmacokinetic Characteristics of Cebranopadol, a Novel First-in-Class Analgesic | Clinical Pharmacokinetic Characteristics of Cebranopadol, a Novel First-in-Class Analgesic Abstract Abstract Background and Objectives Cebranopadol is a novel first-in-class analgesic acting as a nociceptin/orphanin FQ peptide and opioid peptide receptor agonist with central analgesic activity. It is currently in clini... |
PMC8585800 | core_pubmed_pmc | Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data | Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data Abstract Introduction Vortioxetine is an antidepressant primarily metabolized by the polymorphic enzyme cytochrome P450 (CYP) 2D6. A population pharmacokinetic (popPK) model of vortioxetine and its CYP2D6-dependent m... |
PMC9854442 | core_pubmed_pmc | Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review | Pharmacokinetics of Antimicrobials in Children with Emphasis on Challenges Faced by Low and Middle Income Countries, a Clinical Review Abstract Abstract Effective antimicrobial exposure is essential to treat infections and prevent antimicrobial resistance, both being major public health problems in low and middle incom... |
PMC3852831 | core_pubmed_pmc | Urodynamic investigation by telemetry in Beagle dogs: validation and effects of oral administration of current urological drugs: a pilot study | Urodynamic investigation by telemetry in Beagle dogs: validation and effects of oral administration of current urological drugs: a pilot study Abstract Abstract Background Vesico-urethral function may be evaluated in humans and dogs by conventional urodynamic testing (cystometry and urethral pressure profilometry) or b... |
PMC9842066 | core_pubmed_pmc | Implantable device actuated by manual button clicks for noninvasive self‐drug administration | Implantable device actuated by manual button clicks for noninvasive self‐drug administration Abstract Abstract Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a ful... |
PMC5080647 | core_pubmed_pmc | Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help? | Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help? Abstract This subteam under the Drug Metabolism Leadership Group (Innovation and Quality Consortium) investigated the quantitative role of circulating inhi... |
PMC7728077 | core_pubmed_pmc | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials Abstract Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic char... |
PMC12238946 | core_pubmed_pmc | First-in-human phase I open-label study of the anti–TIM-3 monoclonal antibody INCAGN02390 in patients with select advanced or metastatic solid tumors | First-in-human phase I open-label study of the anti–TIM-3 monoclonal antibody INCAGN02390 in patients with select advanced or metastatic solid tumors Abstract Abstract Background T-cell immunoglobulin and mucin domain-containing protein-3 (TIM-3) is an immune checkpoint receptor upregulated during anti-programmed death... |
PMC12439282 | core_pubmed_pmc | Competing Risks Analysis of the Finnish Diabetes Prevention Study | Competing Risks Analysis of the Finnish Diabetes Prevention Study Abstract ABSTRACT Clinical studies often observe one interesting event in the presence of other competing events. When both types of events can occur at any time but are only observed at clinical visits (i.e., interval censored), standard survival models... |
PMC12953449 | core_pubmed_pmc | Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach | Identification of predictive biomarkers and dose optimization for camrelizumab combined with apatinib in the treatment of advanced hepatocellular carcinoma: a quantitative systems pharmacology approach Abstract Introduction The combination of camrelizumab and apatinib represents a promising treatment strategy for patie... |
PMC10046369 | core_pubmed_pmc | Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat | Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat Abstract The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent ... |
PMC9225039 | core_pubmed_pmc | Ecdysteroids as Potent Enzyme Inhibitors and Verification of Their Activity Using In Vitro and In Silico Docking Studies | Ecdysteroids as Potent Enzyme Inhibitors and Verification of Their Activity Using In Vitro and In Silico Docking Studies Abstract Ecdysteroids represent arthropods’ steroidal hormones, and they exist in about 5–6% of plant species. In this study, the enzyme inhibitory activity of 20 ecdysteroids was assessed for the fi... |
PMC4980920 | core_pubmed_pmc | Platelet-to-lymphocyte ratio but not neutrophil-to-lymphocyte ratio predicts high on-treatment platelet reactivity in clopidogrel-treated patients with acute coronary syndrome | Platelet-to-lymphocyte ratio but not neutrophil-to-lymphocyte ratio predicts high on-treatment platelet reactivity in clopidogrel-treated patients with acute coronary syndrome Abstract Abstract Objectives: Dual antiplatelet therapy (DAPT), consisting of clopidogrel and aspirin, is the main-stay treatment of acute coron... |
PMC2797436 | core_pubmed_pmc | Effect of rifampin on the pharmacokinetics of Axitinib (AG-013736) in Japanese and Caucasian healthy volunteers | Effect of rifampin on the pharmacokinetics of Axitinib (AG-013736) in Japanese and Caucasian healthy volunteers Abstract Purpose Axitinib, a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2, 3, is metabolized by cytochrome P450 3A4 and glucuronidation. This study evaluated the effect ... |
PMC3937833 | core_pubmed_pmc | Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone | Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone Abstract Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irrit... |
PMC6824350 | core_pubmed_pmc | Effect of Caffeine on the Bioavailability and Pharmacokinetics of an Acetylsalicylic Acid-Paracetamol Combination: Results of a Phase I Study | Effect of Caffeine on the Bioavailability and Pharmacokinetics of an Acetylsalicylic Acid-Paracetamol Combination: Results of a Phase I Study Abstract Introduction Caffeine is used as an adjuvant in analgesic combinations to enhance their efficacy. The present study aimed to determine the effect of caffeine on the phar... |
PMC6804255 | core_pubmed_pmc | Broccoli or Sulforaphane: Is It the Source or Dose That Matters? | Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Abstract There is robust epidemiological evidence for the beneficial effects of broccoli consumption on health, many of them clearly mediated by the isothiocyanate sulforaphane. Present in the plant as its precursor, glucoraphanin, sulforaphane is formed ... |
PMC9729534 | core_pubmed_pmc | Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke | Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke Abstract Abstract Bai-Mi-Decoction (BMD), which is composed of Eugenia caryophyllata , Myristica fragrans , Moschus berezovskii , and Crocus sativu , is a characteristic TCM multi-herb formula for brain dis... |
PMC9872218 | core_pubmed_pmc | Urinary Pharmacokinetics of Immediate and Controlled Release Oxycodone and its Phase I and II Metabolites Using LC–MS-MS | Urinary Pharmacokinetics of Immediate and Controlled Release Oxycodone and its Phase I and II Metabolites Using LC–MS-MS Abstract Abstract Oxycodone (OC) is a schedule II semisynthetic opioid in the USA that is prescribed for its analgesic effects and has a high potential for abuse. Prescriptions for OC vary based on t... |
PMC12894229 | core_pubmed_pmc | From venom peptides to neurotherapeutics: BmK defensins and short-chain peptides as modulators of ion channels | From venom peptides to neurotherapeutics: BmK defensins and short-chain peptides as modulators of ion channels Abstract Scorpions, having inhabited the Earth long before the emergence of humans, represent an ancient lineage of arthropods. While often regarded with fear due to their potential to induce severe pain or fa... |
PMC7954774 | core_pubmed_pmc | Structural insights on the interaction potential of natural leads against major protein targets of SARS-CoV-2: Molecular modelling, docking and dynamic simulation studies | Structural insights on the interaction potential of natural leads against major protein targets of SARS-CoV-2: Molecular modelling, docking and dynamic simulation studies Abstract Abstract Though significant efforts are in progress for developing drugs and vaccines against COVID-19, limited therapeutic agents are avail... |
PMC7408675 | core_pubmed_pmc | Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients | Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients Abstract Abstract Tacrolimus is a first-line calcineurin inhibitor (CNI) and an integral part of the immunosuppressive strategy in solid organ transplant... |
PMC3201932 | core_pubmed_pmc | Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series | Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series Abstract Introduction The use of methadone as an analgesic is on the increase, but it is widely recognized that the goal of predictable and reproducible dosing is confounded by considerable variability in methadone phar... |
PMC5370399 | core_pubmed_pmc | Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations | Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations Abstract Development of submodels of organs within physiologically-based pharmacokinetic (PBPK) principles and beyond simple perfusion limitations may be chal... |
PMC5840103 | core_pubmed_pmc | Pharmacokinetics, Antiviral Activity, and Safety of Rilpivirine in Pregnant Women with HIV-1 Infection: Results of a Phase 3b, Multicenter, Open-Label Study | Pharmacokinetics, Antiviral Activity, and Safety of Rilpivirine in Pregnant Women with HIV-1 Infection: Results of a Phase 3b, Multicenter, Open-Label Study Abstract Introduction Physiologic changes during pregnancy may impact the pharmacokinetics of drugs. In addition, efficacy and safety/tolerability concerns have be... |
PMC2866686 | core_pubmed_pmc | Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey | Association between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the U.S. National Health and Nutrition Examination Survey Abstract Abstract Background Perfluorooctanoic acid (PFOA, also known as C8) and perfluorooctane sulfonate (PFOS) are stable compounds with many industrial and consumer uses. Their pe... |
PMC8669916 | core_pubmed_pmc | Pharmacogenetics Based Dose Prediction Model for Initial Tacrolimus Dosing in Renal Transplant Recipients | Pharmacogenetics Based Dose Prediction Model for Initial Tacrolimus Dosing in Renal Transplant Recipients Abstract Abstract Tacrolimus, an immunosuppressant used in solid organ transplantation, has a narrow therapeutic index and exhibits inter-individual pharmacokinetic variability. Achieving and maintaining a therapeu... |
PMC9578216 | core_pubmed_pmc | An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria | An area under the concentration–time curve threshold as a predictor of efficacy and nephrotoxicity for individualizing polymyxin B dosing in patients with carbapenem-resistant gram-negative bacteria Abstract Abstract Background Evidence supports therapeutic drug monitoring of polymyxin B, but clinical data for establis... |
PMC7463651 | core_pubmed_pmc | Phase I/Ib Study of Tenalisib (RP6530), a Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma | Phase I/Ib Study of Tenalisib (RP6530), a Dual PI3K δ/γ Inhibitor in Patients with Relapsed/Refractory T-Cell Lymphoma Abstract Abstract Tenalisib (RP6530), a dual phosphoinositide 3-kinase δ/γ inhibitor was evaluated in a phase I/Ib study for maximum tolerated dose (MTD), pharmacokinetics, and efficacy in patients wit... |
PMC12736062 | core_pubmed_pmc | Photodynamic Action of Hypocrellin A and Hypocrellin B against Cancer—A Review | Photodynamic Action of Hypocrellin A and Hypocrellin B against Cancer—A Review Abstract Cancer is a major global health concern, affecting nearly 20 million individuals annually, according to the International Agency for Research on Cancer (IARC). There are some unconventional and conventional treatments for cancer. Ty... |
PMC11086890 | core_pubmed_pmc | The fungicidal effectiveness of 2-Chloro-3-hydrazinylquinoxaline, a newly developed quinoxaline derivative, against Candida species | The fungicidal effectiveness of 2-Chloro-3-hydrazinylquinoxaline, a newly developed quinoxaline derivative, against Candida species Abstract Background Candida represents a prevalent fungal infection, notable for its substantial implications on morbidity and mortality rates. In the landscape of prospective treatments, ... |
PMC12345486 | core_pubmed_pmc | Preliminary Pharmacokinetics and Appetite Stimulant Efficacy of Oral Mirtazapine in Guinea Pigs ( Cavia porcellus ) | Preliminary Pharmacokinetics and Appetite Stimulant Efficacy of Oral Mirtazapine in Guinea Pigs ( Cavia porcellus ) Abstract Simple Summary Guinea pigs are cecal fermenters requiring frequent and consistent feed intake to ensure normal gut motility. Transport, age-related disease, diet changes, and other sources of chr... |
PMC8711605 | core_pubmed_pmc | Week 96 extension results of a Phase 3 study evaluating long-acting cabotegravir with rilpivirine for HIV-1 treatment | Week 96 extension results of a Phase 3 study evaluating long-acting cabotegravir with rilpivirine for HIV-1 treatment Abstract Background: ATLAS (NCT02951052), a phase 3, multicenter, open-label study, demonstrated that switching to injectable cabotegravir (CAB) with rilpivirine (RPV) long-acting dosed every 4 weeks wa... |
PMC8091127 | core_pubmed_pmc | Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients | Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients Abstract Abstract Aim: Kukoamine B, a small molecule compound, is being developed for the treatment of sepsis in a Phase II clinical trial. The objective of this study was to optimize dosing selection for ... |
PMC11370788 | core_pubmed_pmc | Evaluation of Factors Predictive of Efficacy Among Patients With Complicated Urinary Tract Infection and/or Acute Pyelonephritis | Evaluation of Factors Predictive of Efficacy Among Patients With Complicated Urinary Tract Infection and/or Acute Pyelonephritis Abstract Abstract Background Antibiotic treatment for complicated urinary tract infections (cUTI)/acute pyelonephritis (AP) is often followed by recurrent bacteriuria in the absence of clinic... |
PMC3815145 | core_pubmed_pmc | First-day iodine kinetics is useful for individualizing radiation safety precautions for thyroid carcinoma patients | First-day iodine kinetics is useful for individualizing radiation safety precautions for thyroid carcinoma patients Abstract Abstract Objective There is considerable variation in the national regulations of different countries for the release of patients from hospitals after radioiodine therapy. Individual variations m... |
PMC3260134 | core_pubmed_pmc | Anticancer activity of an extract from needles and twigs of Taxus cuspidata and its synergistic effect as a cocktail with 5-fluorouracil | Anticancer activity of an extract from needles and twigs of Taxus cuspidata and its synergistic effect as a cocktail with 5-fluorouracil Abstract Abstract Background Botanical medicines are increasingly combined with chemotherapeutics as anticancer drug cocktails. This study aimed to assess the chemotherapeutic potenti... |
PMC8914174 | core_pubmed_pmc | Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing | Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing Abstract Abstract Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost ex... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.