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PMC11854889 | core_pubmed_pmc | GC-MS Profiling of Ethanol-Extracted Polyherbal Compounds from Medicinal Plant ( Citrullus colocynthis , Curcuma longa , and Myristica fragrans ): In Silico and Analytical Insights into Diabetic Neuropathy Therapy via Targeting the Aldose Reductase | GC-MS Profiling of Ethanol-Extracted Polyherbal Compounds from Medicinal Plant ( Citrullus colocynthis , Curcuma longa , and Myristica fragrans ): In Silico and Analytical Insights into Diabetic Neuropathy Therapy via Targeting the Aldose Reductase Abstract Abstract Diabetic neuropathy is one of the severe complication... |
PMC7578299 | core_pubmed_pmc | The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets | The antiviral effects of baloxavir marboxil against influenza A virus infection in ferrets Abstract Abstract Background Baloxavir marboxil (BXM), the oral prodrug of baloxavir acid (BXA), greatly reduces virus titers as well as influenza symptoms of uncomplicated influenza in patients. Objectives To investigate the pha... |
PMC3298802 | core_pubmed_pmc | Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease | Evaluation of blood-brain barrier transport and CNS drug metabolism in diseased and control brain after intravenous L-DOPA in a unilateral rat model of Parkinson's disease Abstract Abstract Background Changes in blood-brain barrier (BBB) functionality have been implicated in Parkinson's disease. This study aimed to inv... |
PMC5863311 | core_pubmed_pmc | Rethinking the Viability and Utility of Inhaled Insulin in Clinical Practice | Rethinking the Viability and Utility of Inhaled Insulin in Clinical Practice Abstract Abstract Despite considerable advances in pharmacotherapy and self-monitoring technologies in the last decades, a large percentage of adults with diabetes remain unsuccessful in achieving optimal glucose due to suboptimal medication a... |
PMC10865503 | core_pubmed_pmc | Immediate and sustained terminal complement inhibition with ravulizumab in patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder | Immediate and sustained terminal complement inhibition with ravulizumab in patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder Abstract Objective To assess the pharmacokinetics and pharmacodynamics of the long-acting terminal complement 5 (C5) inhibitor ravulizumab in adults with ant... |
PMC11880937 | core_pubmed_pmc | Pharmacokinetics of a single oral administration of two cannabidiol formulations in fed and fasted horses | Pharmacokinetics of a single oral administration of two cannabidiol formulations in fed and fasted horses Abstract Pain management in horses plays a pivotal role in the therapeutic approach to several diseases. Horses have cannabinoid receptors at the level of dorsal root ganglia, blood vessels, and synoviocytes that c... |
PMC2800316 | core_pubmed_pmc | Two Dosages of Oral Fluoropyrimidine S-1 of 35 and 40 mg/m 2 bid: Comparison of the Pharmacokinetic Profiles in Korean Patients with Advanced Gastric Cancer | Two Dosages of Oral Fluoropyrimidine S-1 of 35 and 40 mg/m 2 bid: Comparison of the Pharmacokinetic Profiles in Korean Patients with Advanced Gastric Cancer Abstract Abstract Objective In this study, we compared the pharmacokinetic profiles of 5-fluorouracil (5-FU), tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and po... |
PMC11531824 | core_pubmed_pmc | Population pharmacokinetics of oral fosfomycin calcium in healthy women | Population pharmacokinetics of oral fosfomycin calcium in healthy women Abstract Abstract Background Fosfomycin is an antibiotic extensively used to treat uncomplicated urinary tract infections in women, and it is available in different salts and formulations. The European Medicines Agency (EMA) recommends further stud... |
PMC8819684 | core_pubmed_pmc | Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of CMAB807, a New Denosumab Biosimilar, in Healthy Chinese Subjects | Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of CMAB807, a New Denosumab Biosimilar, in Healthy Chinese Subjects Abstract Abstract Objective: Pharmacokinetics (PK), pharmacodynamics (PD), safety and immunogenicity studies were conducted to evaluate the bioequivalence of CMAB807, a biosimilar to denosum... |
PMC6856034 | core_pubmed_pmc | Optimal Sampling Strategies for Therapeutic Drug Monitoring of First-Line Tuberculosis Drugs in Patients with Tuberculosis | Optimal Sampling Strategies for Therapeutic Drug Monitoring of First-Line Tuberculosis Drugs in Patients with Tuberculosis Abstract Background The 24-h area under the concentration–time curve (AUC 24 )/minimal inhibitory concentration ratio is the best predictive pharmacokinetic/pharmacodynamic (PK/PD) parameter of the... |
PMC4696213 | core_pubmed_pmc | The understanding of core pharmacological concepts among health care students in their final semester | The understanding of core pharmacological concepts among health care students in their final semester Abstract Abstract Background The overall aim of the study was to explore health care students´ understanding of core concepts in pharmacology. Method An interview study was conducted among twelve students in their fina... |
PMC3525213 | core_pubmed_pmc | The Human Cytochrome P450 ( CYP ) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects | The Human Cytochrome P450 ( CYP ) Allele Nomenclature website: a peer-reviewed database of CYP variants and their associated effects Abstract Abstract Pharmacogenetics affects both pharmacokinetics and pharmacodynamics, thereby influencing an individual's response to drugs, both in terms of response and adverse reactio... |
PMC12059348 | core_pubmed_pmc | Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: a pharmacokinetic interaction study in rats in vivo | Hydroxychloroquine increases the exposure of methotrexate in plasma and red blood cells: a pharmacokinetic interaction study in rats in vivo Abstract Abstract Introduction Hydroxychloroquine (HCQ) has been demonstrated to be potential to enhance the therapeutic efficacy of methotrexate (MTX) for rheumatoid arthritis (R... |
PMC11471297 | core_pubmed_pmc | Use of Long-Acting Injectables for Severe Mental Illness in the Peripartum Period: A Case Report and a Scoping Review | Use of Long-Acting Injectables for Severe Mental Illness in the Peripartum Period: A Case Report and a Scoping Review Abstract Abstract The management of acute mania during pregnancy poses a complex clinical task, necessitating careful consideration of treatment options and demanding a delicate balance between the risk... |
PMC11597746 | core_pubmed_pmc | A Pharmacokinetic Study of the Interaction Between Regorafenib and Paracetamol in Male Rats | A Pharmacokinetic Study of the Interaction Between Regorafenib and Paracetamol in Male Rats Abstract Background : In clinical practice, the prevalent problem of polypharmacy could result in increased risks of drug–drug interactions. Regorafenib (REG) is commonly co-administered with paracetamol (PA) as a treatment prot... |
PMC10587682 | core_pubmed_pmc | Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study | Modeling the protein binding non-linearity in population pharmacokinetic model of valproic acid in children with epilepsy: a systematic evaluation study Abstract Background: Several studies have investigated the population pharmacokinetics (popPK) of valproic acid (VPA) in children with epilepsy. However, the predictiv... |
PMC4751284 | core_pubmed_pmc | A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model | A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model Abstract Development of iniparib as an anti-cancer agent was hindered in part by lingering questions regarding its mechanism of action, the activity of its metabolites, and t... |
PMC9026017 | core_pubmed_pmc | Investigating the Potential Use of Andrographolide as a Coadjuvant in Sickle Cell Anemia Therapy | Investigating the Potential Use of Andrographolide as a Coadjuvant in Sickle Cell Anemia Therapy Abstract Andrographolide is one of the main active principles of Andrographolide paniculata and has been extensively explored for its therapeutic use. Current studies focus on phytotherapeutics-based adjuvant therapy to sym... |
PMC6349812 | core_pubmed_pmc | Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome | Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome Abstract Nephrotic syndrome is one of the most common glomerular disorders in childhood. Glucocorticoids have been the cornerstone of the treatment of childhood nephrotic syndrome for several decades, as the majority of... |
PMC4243902 | core_pubmed_pmc | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling | Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling Abstract Abstract Aims The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two... |
PMC8201112 | core_pubmed_pmc | Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies | Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies Abstract Simple Summary High-dose methotrexate is commonly used to treat several types of cancer. While effective, elimination of high-dose methotrexate from the body is highly variable and dela... |
PMC11291427 | core_pubmed_pmc | Pharmacokinetics of oxytetracycline in hybrid catfish ( Clarias macrocephalus x C. gariepinus ) after intravascular and oral administrations | Pharmacokinetics of oxytetracycline in hybrid catfish ( Clarias macrocephalus x C. gariepinus ) after intravascular and oral administrations Abstract Importance Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish ( Cla... |
PMC8844994 | core_pubmed_pmc | Using Electronic Health Records for Personalized Dosing of Intravenous Vancomycin in Critically Ill Neonates: Model and Web-Based Interface Development Study | Using Electronic Health Records for Personalized Dosing of Intravenous Vancomycin in Critically Ill Neonates: Model and Web-Based Interface Development Study Abstract Abstract Background Intravenous (IV) vancomycin is used in the treatment of severe infection in neonates. However, its efficacy is compromised by elevate... |
PMC12015468 | core_pubmed_pmc | Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis | Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis Abstract Abstract Background Host immune responses to HIV-associated cryptococcal meningitis are critical in disease outcome. Their interaction with antifungal drug exposure is po... |
PMC9579396 | core_pubmed_pmc | First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers | First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers Abstract Abstract HDIT101 is a first‐in‐class humanized monoclonal antibody recognizing a conserved epitope in glycoprotein B, a target present on the su... |
PMC10772511 | core_pubmed_pmc | Product Attributes of CAR T-cell Therapy Differentially Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma (ZUMA-7) | Product Attributes of CAR T-cell Therapy Differentially Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma (ZUMA-7) Abstract Abstract Treatment resistance and toxicities remain a risk following chimeric antigen receptor (CAR) T-cell therapy. Herein, we report pharmacokinetics, pharmacodynamics, a... |
PMC9825453 | core_pubmed_pmc | DrugMAP: molecular atlas and pharma-information of all drugs | DrugMAP: molecular atlas and pharma-information of all drugs Abstract Abstract The efficacy and safety of drugs are widely known to be determined by their interactions with multiple molecules of pharmacological importance, and it is therefore essential to systematically depict the molecular atlas and pharma-information... |
PMC6989267 | core_pubmed_pmc | Evolving role of modeling and simulation in drug development | Evolving role of modeling and simulation in drug development Abstract Abstract Pharmacokinetic-pharmacodynamic model is a kind of language that quantitatively describes the drug-related outcomes in the form of mathematical formula. Various outcomes can be subjected to modeling analysis if they can be expressed in numbe... |
PMC7021855 | core_pubmed_pmc | Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study | Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study Abstract Abstract Introduction Spebrutinib (CC-292) is an orally administered, covalent, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK), part of the ... |
PMC7647722 | core_pubmed_pmc | The effect of supplementary ultraviolet wavelengths on the performance of broiler chickens | The effect of supplementary ultraviolet wavelengths on the performance of broiler chickens Abstract Qualities of the light environment, such as the spectral composition of light, have been shown to impact growth and performance of broiler chickens. UVA light is visible to broiler chickens, whereas UVB wavelengths promo... |
PMC10583566 | core_pubmed_pmc | Revealing the dynamic landscape of drug-drug interactions through network analysis | Revealing the dynamic landscape of drug-drug interactions through network analysis Abstract Introduction: The landscape of drug-drug interactions (DDIs) has evolved significantly over the past 60 years, necessitating a retrospective analysis to identify research trends and under-explored areas. While methodologies like... |
PMC5651349 | core_pubmed_pmc | Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor | Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor Abstract Abstract Objectives Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, JNJ-54861911, were assessed aft... |
PMC11275388 | core_pubmed_pmc | The Preparation and Evaluation of a Hydrochloride Hydrogel Patch with an Iontophoresis-Assisted Release of Terbinafine for Transdermal Delivery | The Preparation and Evaluation of a Hydrochloride Hydrogel Patch with an Iontophoresis-Assisted Release of Terbinafine for Transdermal Delivery Abstract Abstract Background: Terbinafine hydrochloride (TEB) is a broad-spectrum antifungal medication commonly used to treat fungal infections of the skin. This study designe... |
PMC5562140 | core_pubmed_pmc | Nonvitamin K antagonist oral anticoagulant use in patients with renal impairment | Nonvitamin K antagonist oral anticoagulant use in patients with renal impairment Abstract Abstract The nonvitamin K antagonist oral anticoagulants (NOACs), also referred to as direct oral anticoagulants (DOACs), dabigatran, apixaban, edoxaban, and rivaroxaban, have emerged as effective alternatives to vitamin K antagon... |
PMC12813969 | core_pubmed_pmc | Cefiderocol Elimination During Peritoneal Dialysis: A Short Report | Cefiderocol Elimination During Peritoneal Dialysis: A Short Report Abstract Cefiderocol is a siderophore cephalosporin with potent activity against multidrug-resistant Gram-negative pathogens, yet pharmacokinetic data for patients receiving peritoneal dialysis (PD) are lacking. We report the first clinical observation ... |
PMC7033403 | core_pubmed_pmc | Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions | Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions Abstract Abstract Two separate studies were conducted to establish bioequivalence (BE) for two doses of atorvastatin/metformi... |
PMC12559525 | core_pubmed_pmc | A comprehensive review of alkaloids in cancer therapy: focusing on molecular mechanisms and synergistic potential of piperine in colorectal cancer | A comprehensive review of alkaloids in cancer therapy: focusing on molecular mechanisms and synergistic potential of piperine in colorectal cancer Abstract Alkaloids exhibit a wide range of anticancer activities, including the induction of apoptosis, regulation of autophagy, arrest of the cell cycle, inhibition of angi... |
PMC4065678 | core_pubmed_pmc | Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept | Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept Abstract Abstract Ankylosing spondylitis (AS) is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF) α are effec... |
PMC3265487 | core_pubmed_pmc | Lentiviral Transgenic MicroRNA-Based shRNA Suppressed Mouse Cytochromosome P450 3A (CYP3A) Expression in a Dose-Dependent and Inheritable Manner | Lentiviral Transgenic MicroRNA-Based shRNA Suppressed Mouse Cytochromosome P450 3A (CYP3A) Expression in a Dose-Dependent and Inheritable Manner Abstract Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. T... |
PMC4865542 | core_pubmed_pmc | Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment | Pharmacodynamic modeling of adverse effects of anti-cancer drug treatment Abstract Abstract Purpose Adverse effects related to anti-cancer drug treatment influence patient’s quality of life, have an impact on the realized dosing regimen, and can hamper response to treatment. Quantitative models that relate drug exposur... |
PMC12905990 | core_pubmed_pmc | From qualitative prediction to quantitative insight: combined meteorological patterns and regional dynamics of severe fever with thrombocytopenia syndrome in Liaoning Province, China, 2010–2024 | From qualitative prediction to quantitative insight: combined meteorological patterns and regional dynamics of severe fever with thrombocytopenia syndrome in Liaoning Province, China, 2010–2024 Abstract Abstract Background Severe fever with thrombocytopenia syndrome(SFTS) is an emerging tick-borne disease with an expan... |
PMC12257032 | core_pubmed_pmc | Metformin efficacy and tolerance according to genetic polymorphisms of organic cation transporter 1 in Tunisian patients with type 2 diabetes | Metformin efficacy and tolerance according to genetic polymorphisms of organic cation transporter 1 in Tunisian patients with type 2 diabetes Abstract Purpose Metformin efficacy and tolerance vary at equivalent dose in type 2 diabetes. Inter-individual variability in the response to metformin with approximately 35% of ... |
PMC9966293 | core_pubmed_pmc | Breynia cernua : Chemical Profiling of Volatile Compounds in the Stem Extract and Its Antioxidant, Antibacterial, Antiplasmodial and Anticancer Activity In Vitro and In Silico | Breynia cernua : Chemical Profiling of Volatile Compounds in the Stem Extract and Its Antioxidant, Antibacterial, Antiplasmodial and Anticancer Activity In Vitro and In Silico Abstract Breynia cernua has been used as an alternative medicine for wounds, smallpox, cervical cancer, and breast cancer. This plant is a poten... |
PMC12246443 | core_pubmed_pmc | Exploring the impact of three meteorological factors and their specific effect sizes on chronic obstructive pulmonary disease admission in Qingyang, China | Exploring the impact of three meteorological factors and their specific effect sizes on chronic obstructive pulmonary disease admission in Qingyang, China Abstract It’s unclear exactly how variations in a number of meteorological factors relate to the chance of being hospitalized with COPD. The majority of earlier rese... |
PMC10966180 | core_pubmed_pmc | Abelacimab: A leap forward in anticoagulation with FXI and FXIa Inhibition | Abelacimab: A leap forward in anticoagulation with FXI and FXIa Inhibition Abstract Abstract Direct Oral Anticoagulants (DOACs) have revolutionized the treatment of thromboembolic disorders, offering targeted, effective, and safer alternatives to traditional anticoagulants like heparins and vitamin K antagonists (VKAs)... |
PMC7897905 | core_pubmed_pmc | Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors | Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors Abstract Abstract Olaratumab is a monoclonal antibody that specifically binds to platelet‐derived growth factor receptor alpha (PDGFRα) and blocks receptor ... |
PMC3380549 | core_pubmed_pmc | A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: improvements and limitations | A review of modern insulin analogue pharmacokinetic and pharmacodynamic profiles in type 2 diabetes: improvements and limitations Abstract Insulin analogues have been engineered to enhance desired molecular properties without altering immunogenicity. The majority of insulin pharmacology studies are conducted in healthy... |
PMC8915896 | core_pubmed_pmc | Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future | Internal Threshold of Toxicological Concern (iTTC): Where We Are Today and What Is Possible in the Near Future Abstract Abstract The Threshold of Toxicological Concern (TTC) is a risk assessment tool for evaluating low-level exposure to chemicals with limited toxicological data. A next step in the ongoing development o... |
PMC8803749 | core_pubmed_pmc | Systematic Review of the Pharmacological Evidence for the Selection of Antimicrobials in Bacterial Infections of the Central Nervous System in Dogs and Cats | Systematic Review of the Pharmacological Evidence for the Selection of Antimicrobials in Bacterial Infections of the Central Nervous System in Dogs and Cats Abstract Bacterial meningitis in dogs and cats is a rare disease associated with a high lethality rate. The spectrum of causative bacteria includes a diverse set o... |
PMC6714879 | core_pubmed_pmc | The Renal Elimination Pathways of the Dabigatran Reversal Agent Idarucizumab and its Impact on Dabigatran Elimination | The Renal Elimination Pathways of the Dabigatran Reversal Agent Idarucizumab and its Impact on Dabigatran Elimination Abstract Idarucizumab, a humanized monoclonal antibody fragment (Fab), provides rapid and sustained reversal of dabigatran-mediated anticoagulation. Idarucizumab and dabigatran are mainly eliminated via... |
PMC8422903 | core_pubmed_pmc | Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS | Validation of a Triplex Pharmacokinetic Assay for Simultaneous Quantitation of HIV-1 Broadly Neutralizing Antibodies PGT121, PGDM1400, and VRC07-523-LS Abstract Abstract The outcome of the recent Antibody Mediated Prevention (AMP) trials that tested infusion of the broadly neutralizing antibody (bnAb) VRC01 provides pr... |
PMC11368109 | core_pubmed_pmc | A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx ® in Healthy Chinese Male Subjects | A Randomized, Double-Blind, Parallel-Group Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of CMAB015, a Candidate Secukinumab Biosimilar, with Its Reference Product Cosentyx ® in Healthy Chinese Male Subjects Abstract Purpose Secukinumab, a monoclonal antibody targeting interleukin (IL)-17A, i... |
PMC5655093 | core_pubmed_pmc | Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence | Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence Abstract ABSTRACT In pharmacokinetic/pharmacodynamic models of pulmonary Mycobacterium abscessus complex, the recommended macrolide-containing combination therapy has poor kill rates. H... |
PMC8841444 | core_pubmed_pmc | Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non‐Japanese | Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non‐Japanese Abstract Abstract Cenobamate (XCOPRI and ONTOZRY) is a novel antiseizure medication for the treatment of focal‐onset seizures. Nonetheless, there is limited information on t... |
PMC9283741 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics profiles of enteric‐coated mycophenolate sodium in female patients with difficult‐to‐treat lupus nephritis | Pharmacokinetics and pharmacodynamics profiles of enteric‐coated mycophenolate sodium in female patients with difficult‐to‐treat lupus nephritis Abstract Abstract Relapsed or resistant lupus nephritis (LN) is considered a difficult‐to‐treat type of LN, and enteric‐coated mycophenolate sodium (EC‐MPS) has been used in t... |
PMC11886941 | core_pubmed_pmc | Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005 , a C1q Inhibitor, in Patients With Guillain–Barré Syndrome | Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005 , a C1q Inhibitor, in Patients With Guillain–Barré Syndrome Abstract ABSTRACT Background and Aims Guillain–Barré syndrome (GBS) is an acute autoimmune peripheral neuropathy driven by autoantibodi... |
PMC6709425 | core_pubmed_pmc | Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer | Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer Abstract Bevacizumab‐pemetrexed/cisplatin ( BEV ‐ PEM / CIS ) is a first‐line therapeutic for advanced nonsquamous non‐small cell lung cancer. Bevacizumab potentiates PEM / CIS cytotoxicity by inducing transient tumor vascul... |
PMC8857873 | core_pubmed_pmc | IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET) | IMI2-PainCare-BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET) Abstract Backgrou... |
PMC9543358 | core_pubmed_pmc | Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects | Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects Abstract Aim To characterize cabotegravir population pharmacokinetics using data from phase 1, 2 and 3 studies and evaluate the association of intri... |
PMC12850606 | core_pubmed_pmc | Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria | Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated Plasmodium falciparum malaria Abstract Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged... |
PMC9147223 | core_pubmed_pmc | Semi-Automated Therapeutic Drug Monitoring as a Pillar toward Personalized Medicine for Tuberculosis Management | Semi-Automated Therapeutic Drug Monitoring as a Pillar toward Personalized Medicine for Tuberculosis Management Abstract Standard tuberculosis (TB) management has failed to control the growing number of drug-resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate TB. Model-informed prec... |
PMC3834932 | core_pubmed_pmc | Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers | Bioavailability of a Lipidic Formulation of Curcumin in Healthy Human Volunteers Abstract Numerous publications have reported the significant pharmacodynamic activity of Curcumin (CRM) despite low or undetectable levels in plasma. The objective of the present study was to perform a detailed pharmacokinetic evaluation o... |
PMC8096952 | core_pubmed_pmc | Similar pharmacokinetics and pharmacodynamics of a new biosimilar and reference insulin aspart in healthy Chinese males | Similar pharmacokinetics and pharmacodynamics of a new biosimilar and reference insulin aspart in healthy Chinese males Abstract Abstract Insulin aspart (IAsp) is one of the main therapies used to control blood glucose after a meal. This study aimed to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of 2 ra... |
PMC5725891 | core_pubmed_pmc | Mannitol and the blood-labyrinth barrier | Mannitol and the blood-labyrinth barrier Abstract Background Characterization of the blood labyrinth barrier (BLB) is extremely important to determine whether the BLB can be manipulated pharmacologically. However, experiments to investigate the BLB are technically difficult to perform. In this report, we demonstrated a... |
PMC7692975 | core_pubmed_pmc | Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial | Assessing the safety and pharmacokinetics of the anti-HIV monoclonal antibody CAP256V2LS alone and in combination with VRC07-523LS and PGT121 in South African women: study protocol for the first-in-human CAPRISA 012B phase I clinical trial Abstract Abstract Introduction New HIV prevention strategies are urgently requir... |
PMC6406317 | core_pubmed_pmc | Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer | Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer Abstract Abstract Inter-individual variability in paclitaxel pharmacokinetics may play a role in the response to chemotherapy. Therefore, we studied the association between paclitaxel clearance and treatment response in patie... |
PMC8246733 | core_pubmed_pmc | Individual Atrasentan Exposure is Associated With Long‐term Kidney and Heart Failure Outcomes in Patients With Type 2 Diabetes and Chronic Kidney Disease | Individual Atrasentan Exposure is Associated With Long‐term Kidney and Heart Failure Outcomes in Patients With Type 2 Diabetes and Chronic Kidney Disease Abstract Abstract Atrasentan, an endothelin receptor antagonist, showed clinically significant albuminuria reduction with minimal signs of fluid retention in phase II... |
PMC12247600 | core_pubmed_pmc | Pharmacokinetics of cannabidiol and its two main phase I metabolites in Connemara ponies | Pharmacokinetics of cannabidiol and its two main phase I metabolites in Connemara ponies Abstract Introduction Cannabidiol (CBD) has shown potential therapeutic benefits in veterinary medicine, but further investigations are needed to establish its pharmacokinetics and therapeutic dosing in horses and ponies. The prese... |
PMC3531317 | core_pubmed_pmc | Chapter 7: Pharmacogenomics | Chapter 7: Pharmacogenomics Abstract There is great variation in drug-response phenotypes, and a “one size fits all” paradigm for drug delivery is flawed. Pharmacogenomics is the study of how human genetic information impacts drug response, and it aims to improve efficacy and reduced side effects. In this article, we p... |
PMC11974209 | core_pubmed_pmc | The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis | The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis Abstract Background Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium–glucose cotransporter 2 (SGLT2) inhibitors represent a new generation of ... |
PMC8452096 | core_pubmed_pmc | Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. | Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. Abstract Abstract The COVID-19 pandemic remains uncontrolled despite the rapid rollout of safe and effective SARS-CoV-2 vaccines, underscoring the need to develop highly effective antivirals. In the setting of wanin... |
PMC7017297 | core_pubmed_pmc | Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221 | Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221 Abstract Abstract LNA-i-miR-221 is a novel phosphorothioate backbone 13-mer locked nucleic acid oligonucleotide-targeting microRNA-221 designed for the treatment of human malig... |
PMC10374931 | core_pubmed_pmc | Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis | Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis Abstract Objective In response to the differences in pharmacodynamic and pharmacokinetic characteristics of neuromuscular blocking agents between children and adult... |
PMC4351835 | core_pubmed_pmc | Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays | Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays Abstract Abstract Traditional anticoagulant agents such as vitamin K antagonists (VKAs), unfractionated heparin (UFH), low molecular weight heparins (LMWHs) and fondaparinux have been widely used in the prevention a... |
PMC4618645 | core_pubmed_pmc | Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis | Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis Abstract Our previous studies revealed that sesamin caused a mechanism-based inhibition (MBI) of CYP2C9 in human liver microsomes. Additionally, we observed a similar MBI of CYP2C by sesamin in the rat liver microsomes. Sesamin-... |
PMC4832308 | core_pubmed_pmc | A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanced solid tumors or multiple myeloma | A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanced solid tumors or multiple myeloma Abstract Abstract BACKGROUND The mammalian target of rapamycin (mTOR) pathway is essential for tumor dev... |
PMC12546782 | core_pubmed_pmc | Targeting norovirus RdRp: A computational study on the inhibitory potential of ursolic acid and apigenin-7-O-glucoside | Targeting norovirus RdRp: A computational study on the inhibitory potential of ursolic acid and apigenin-7-O-glucoside Abstract Abstract Objective Norovirus is a highly contagious pathogen responsible for significant global morbidity and mortality due to severe gastrointestinal illnesses, particularly in settings such ... |
PMC12823296 | core_pubmed_pmc | A Nonparametric Population Pharmacokinetic Model of Selumetinib in Pediatric Patients Diagnosed With Neurofibromatosis‐I or Plexiform Neurofibromas | A Nonparametric Population Pharmacokinetic Model of Selumetinib in Pediatric Patients Diagnosed With Neurofibromatosis‐I or Plexiform Neurofibromas Abstract ABSTRACT A twice‐daily administration of oral selumetinib (SLT) in the fasted state is the only approved pharmaceutical option for treating inoperable neurofibroma... |
PMC9182892 | core_pubmed_pmc | Is Time-Restricted Eating Safe in the Treatment of Type 2 Diabetes?—A Review of Intervention Studies | Is Time-Restricted Eating Safe in the Treatment of Type 2 Diabetes?—A Review of Intervention Studies Abstract Abstract Time-restricted eating (TRE) has been shown to improve body weight and glucose metabolism in people at high risk of type 2 diabetes. However, the safety of TRE in the treatment of type 2 diabetes is un... |
PMC7909551 | core_pubmed_pmc | Population Pharmacokinetics Analysis of Amikacin Initial Dosing Regimen in Elderly Patients | Population Pharmacokinetics Analysis of Amikacin Initial Dosing Regimen in Elderly Patients Abstract There are limited data of amikacin pharmacokinetics (PK) in the elderly population. Hence, we aimed to describe the population PK of amikacin in elderly patients (>70 years old) and to establish optimized initial dosing... |
PMC10266225 | core_pubmed_pmc | Determination of the 95% effective dose of remimazolam tosylate in anesthesia induction inhibits endotracheal intubation response in senile patients | Determination of the 95% effective dose of remimazolam tosylate in anesthesia induction inhibits endotracheal intubation response in senile patients Abstract Background and Purpose: The prevalence of elderly patients prompts anesthesiologists to determine the optimal dose of medication due to the altered pharmacokineti... |
PMC8923182 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Acceptability of Oral and Long-Acting Cabotegravir in HIV-Negative Chinese Men | Safety, Tolerability, Pharmacokinetics, and Acceptability of Oral and Long-Acting Cabotegravir in HIV-Negative Chinese Men Abstract ABSTRACT Long-acting (LA) cabotegravir demonstrated superior efficacy versus daily oral standard-of-care for HIV-1 preexposure prophylaxis. This phase 1 study assessed safety, tolerability... |
PMC8201735 | core_pubmed_pmc | Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin | Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin Abstract Background Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular... |
PMC9246934 | core_pubmed_pmc | Effects of excessive alcohol drinking on nicotine biotransformation in rats | Effects of excessive alcohol drinking on nicotine biotransformation in rats Abstract Abstract Alcohol and nicotine (tobacco smoke) are often used together, and taking both addictive substances is associated with an increased risk of certain diseases. It is extremely important to understand the pharmacodynamic and pharm... |
PMC7970697 | core_pubmed_pmc | Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method | Inhibition and Induction by Poziotinib of Different Rat Cytochrome P450 Enzymes In Vivo and in an In Vitro Cocktail Method Abstract Abstract Poziotinib is an orally active, irreversible, pan-HER tyrosine kinase inhibitor used to treat non-small cell lung cancer, breast cancer, and gastric cancer. Poziotinib is currentl... |
PMC4611158 | core_pubmed_pmc | Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats | Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats Abstract High doses of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine can elicit somatic signs resembling those associated with nicotine withdrawal in nicotine-naïve adult rats. Understanding this phenomen... |
PMC8688178 | core_pubmed_pmc | Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics | Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics Abstract Objective By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Altho... |
PMC10621790 | core_pubmed_pmc | Simulating clinical trials for model-informed precision dosing: using warfarin treatment as a use case | Simulating clinical trials for model-informed precision dosing: using warfarin treatment as a use case Abstract Abstract Treatment response variability across patients is a common phenomenon in clinical practice. For many drugs this inter-individual variability does not require much (if any) individualisation of dosing... |
PMC9686758 | core_pubmed_pmc | Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin | Pharmacological Activity, Pharmacokinetics, and Clinical Research Progress of Puerarin Abstract As a kind of medicine and food homologous plant, kudzu root ( Pueraria lobata (Willd.) Ohwi ) is called an “official medicine” in Chinese folk medicine. Puerarin is the main active component extracted from kudzu root, and it... |
PMC6207998 | core_pubmed_pmc | Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection | Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection Abstract Purpose Quantitative understanding of the transport of therapeutic macromolecules following intraocular injections is critical for the design of efficient strategies in treating eye diseases, such as neovascular (wet) age-rela... |
PMC11595143 | core_pubmed_pmc | Population Pharmacokinetic Model of Vitamin D 3 and Metabolites in Chronic Kidney Disease Patients with Vitamin D Insufficiency and Deficiency | Population Pharmacokinetic Model of Vitamin D 3 and Metabolites in Chronic Kidney Disease Patients with Vitamin D Insufficiency and Deficiency Abstract Abstract Vitamin D insufficiency and deficiency are highly prevalent in patients with chronic kidney disease (CKD), and their pharmacokinetics are not well described. T... |
PMC11959933 | core_pubmed_pmc | Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study | Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study Abstract Peptide receptor radionuclide therapy (PRRT) with radiolabeled SSTR2 agonists is a treatment option tha... |
PMC12844755 | core_pubmed_pmc | Population Pharmacokinetics and Model-Informed Dose Optimization of Teicoplanin in Adults with Hematological Malignancies | Population Pharmacokinetics and Model-Informed Dose Optimization of Teicoplanin in Adults with Hematological Malignancies Abstract Abstract Background: Teicoplanin is widely used for the empirical and targeted treatment of febrile neutropenia in patients with hematological malignancies. However, the pathophysiological ... |
PMC7867136 | core_pubmed_pmc | Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5 | Anti-Infective and Anti-Inflammatory Mode of Action of Peptide 19-2.5 Abstract Abstract The polypeptide Pep19-2.5 (Aspidasept ® ) has been described to act efficiently against infection-inducing bacteria by binding and neutralizing their most potent toxins, i.e., lipopolysaccharides (LPS) and lipoproteins/peptides (LP)... |
PMC7913753 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum : Clinical and Forensic Aspects | Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum : Clinical and Forensic Aspects Abstract Abstract Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S. divinorum had b... |
PMC12564667 | core_pubmed_pmc | Anticoagulation Therapies and microRNAs in Heart Failure | Anticoagulation Therapies and microRNAs in Heart Failure Abstract Heart Failure (HF) remains a major cause of mortality despite the advances in pharmacological treatment. Anticoagulation therapies, including Clopidogrel, Aspirin, Warfarin, and novel oral anticoagulants (NOACs) such as Apixaban, Rivaroxaban, Edoxaban, a... |
PMC12669112 | core_pubmed_pmc | From bench to bedside, boswellic acids in anti-inflammatory therapy — mechanistic insights, bioavailability challenges, and optimization approaches | From bench to bedside, boswellic acids in anti-inflammatory therapy — mechanistic insights, bioavailability challenges, and optimization approaches Abstract Boswellic acids (BAs), a group of pentacyclic triterpenoids derived from the gum resin of Boswellia species, exhibit promising anti-inflammatory potential through ... |
PMC3118832 | core_pubmed_pmc | Orally Formulated Artemisinin in Healthy Fasting Vietnamese Male Subjects: A Randomized, Four-Sequence, Open-Label, Pharmacokinetic Crossover Study | Orally Formulated Artemisinin in Healthy Fasting Vietnamese Male Subjects: A Randomized, Four-Sequence, Open-Label, Pharmacokinetic Crossover Study Abstract Background Artemisinin derivatives are used in antimalarial drug combination therapy. Artemisinin and piperaquine have recently been proven to be prospective candi... |
PMC7723291 | core_pubmed_pmc | A new pharmacodynamic approach to study antibiotic combinations against enterococci in vivo : Application to ampicillin plus ceftriaxone | A new pharmacodynamic approach to study antibiotic combinations against enterococci in vivo : Application to ampicillin plus ceftriaxone Abstract The combination of ampicillin (AMP) and ceftriaxone (CRO) is considered synergistic against Enterococcus faecalis based on in vitro tests and the rabbit endocarditis model, h... |
PMC12664493 | core_pubmed_pmc | Asparagine endopeptidase (AEP) inhibitor formulation via zein-based nanoparticle improves the therapeutic efficacy toward Alzheimer's disease | Asparagine endopeptidase (AEP) inhibitor formulation via zein-based nanoparticle improves the therapeutic efficacy toward Alzheimer's disease Abstract Asparagine endopeptidase (AEP) plays a critical role in Alzheimer's disease (AD) by cleaving amyloid precursor protein (APP) at N585 and tau protein at N368. Genetic del... |
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