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PMC4224420 | core_pubmed_pmc | Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics | Unsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamics Abstract With the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the interm... |
PMC7469251 | core_pubmed_pmc | Gestational Age–Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics | Gestational Age–Dependent Abundance of Human Placental Transporters as Determined by Quantitative Targeted Proteomics Abstract Abstract Some women take medication during pregnancy to address a variety of clinical conditions. Because of ethical and logistical concerns, it is impossible to determine fetal drug exposure, ... |
PMC3289390 | core_pubmed_pmc | Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action | Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action Abstract Abstract Conventional chemotherapeutic agents are often toxic not only to tumor cells but also to normal cells, limiting their therapeutic use in the clinic. Novel natural pr... |
PMC4467237 | core_pubmed_pmc | Effects of Ketoconazole on the Pharmacokinetics of Lenvatinib (E7080) in Healthy Participants | Effects of Ketoconazole on the Pharmacokinetics of Lenvatinib (E7080) in Healthy Participants Abstract Background Lenvatinib is an oral, multitargeted, tyrosine kinase inhibitor under clinical investigation in solid tumors. In vitro evidence indicates that lenvatinib metabolism may be modulated by ketoconazole, an inhi... |
PMC10059125 | core_pubmed_pmc | The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics | The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics Abstract Abstract Current evidence supports the use of extra virgin olive oil (EVOO) and its minor components such as hydroxytyrosol or 3,4-dihydroxyphenyl ethanol (DOPET), to improve cardiovascular and metabolic health. Nevertheless... |
PMC12888862 | core_pubmed_pmc | An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of Klebsiella pneumoniae pneumonia | An alveolar macrophage-targeted ciprofloxacin polymeric prodrug improves survival in a murine model of Klebsiella pneumoniae pneumonia Abstract ABSTRACT Klebsiella pneumoniae is a leading cause of both hospital- and community-acquired pneumonia. Nanomaterials have the potential to deliver antibiotics directly to sites ... |
PMC11451978 | core_pubmed_pmc | Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays | Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays Abstract Abstract Disease associated pathological aggregates of alpha-synuclein (αSyn D ) exhibit prion-like spreading in synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).... |
PMC11170845 | core_pubmed_pmc | Population pharmacokinetics and dose optimization of magnesium sulfate in Chinese preeclampsia population | Population pharmacokinetics and dose optimization of magnesium sulfate in Chinese preeclampsia population Abstract Abstract Objective To establish the population pharmacokinetics (PPK) of magnesium sulfate (MgSO 4 )in women with preeclampsia (PE), and to determine the key covariates having an effect in magnesium pharma... |
PMC5473410 | core_pubmed_pmc | Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials | Dose Titration Algorithm Tuning (DTAT) should supersede ‘the’ Maximum Tolerated Dose (MTD) in oncology dose-finding trials Abstract Background . Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent ‘confirmatory’ Phase III trials risk suboptimal dosing, with resulting loss of statisti... |
PMC12027173 | core_pubmed_pmc | Pharmacogenomic and Pharmacomicrobiomic Aspects of Drugs of Abuse | Pharmacogenomic and Pharmacomicrobiomic Aspects of Drugs of Abuse Abstract Background/Objectives: This review examines the role of pharmacogenomics in individual responses to the pharmacotherapy of various drugs of abuse, including alcohol, cocaine, and opioids, to identify genetic variants that contribute to variabili... |
PMC7414100 | core_pubmed_pmc | Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo | Thermoresponsive sol-gel improves ocular bioavailability of Dipivefrin hydrochloride and potentially reduces the elevated intraocular pressure in vivo Abstract The present study involves the development of Dipivefrin hydrochloride (DV) containing Poloxamers (P407 and P188)-Carbopol-934 (CP) based thermoresponsive-gels ... |
PMC7138916 | core_pubmed_pmc | Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats | Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats Abstract Abstract In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pha... |
PMC5973995 | core_pubmed_pmc | Vortioxetine: Clinical Pharmacokinetics and Drug Interactions | Vortioxetine: Clinical Pharmacokinetics and Drug Interactions Abstract Abstract Vortioxetine is a novel antidepressant with multimodal activity currently approved for the treatment of major depressive disorder. Vortioxetine is orally administered once daily at 5- to 20-mg doses. The pharmacokinetics of vortioxetine are... |
PMC9636444 | core_pubmed_pmc | Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial | Safety of sildenafil in premature infants at risk of bronchopulmonary dysplasia: Rationale and methods of a phase II randomized trial Abstract Abstract Bronchopulmonary dysplasia (BPD) is a disease of chronic respiratory insufficiency stemming from premature birth and iatrogenic lung injury leading to alveolar simplifi... |
PMC8604880 | core_pubmed_pmc | Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases | Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases Abstract There are several antibody therapeutics in preclinical and clinical development, industry-wide, for the treatment of central nervous system (CNS) disorders. Due to the limited permeability of ... |
PMC12443583 | core_pubmed_pmc | Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial | Defactinib with avutometinib in patients with solid tumors: the phase 1 FRAME trial Abstract Use of signal transduction inhibitors as single agents to treat cancer leads to resistance because of the plasticity of intracellular signaling, and combination therapy can overcome this. We describe the first-in-human trial of... |
PMC12481485 | core_pubmed_pmc | Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer | Development of Optimized Exatecan-Based Immunoconjugates with Potent Antitumor Efficacy in HER2-Positive Breast Cancer Abstract The prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer has significantly improved with the advent of anti-HER2 therapies, especially antibody-drug conjugates (... |
PMC3884839 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis | Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis Abstract SUMMARY This review presents a progression strategy for the discovery of new anti-parasitic d... |
PMC10822116 | core_pubmed_pmc | In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease | In vitro and in vivo Biological Evaluation of Newly Tacrine-Selegiline Hybrids as Multi-Target Inhibitors of Cholinesterases and Monoamine Oxidases for Alzheimer’s Disease Abstract Purpose Alzheimer’s disease (AD) is the most common neurodegenerative disease, and its multifactorial nature increases the difficulty of me... |
PMC9205434 | core_pubmed_pmc | In vitro Antibacterial Activity and Resistance Prevention of Antimicrobial Combinations for Dihydropteroate Synthase-Carrying Stenotrophomonas maltophilia | In vitro Antibacterial Activity and Resistance Prevention of Antimicrobial Combinations for Dihydropteroate Synthase-Carrying Stenotrophomonas maltophilia Abstract Abstract Background Stenotrophomonas maltophilia ( S. maltophilia ) is a multidrug-resistant gram-negative bacillus that is known to be an opportunistic pat... |
PMC12847419 | core_pubmed_pmc | Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review | Population pharmacokinetics of imipenem in different populations for individualized dosing: a systematic review Abstract Abstract Background Imipenem is a broad-spectrum carbapenem antibiotic for severe infections with significant pharmacokinetic (PK) variability. This review systematically synthesized published popula... |
PMC4875921 | core_pubmed_pmc | Characterisation of Population Pharmacokinetics and Endogenous Follicle-Stimulating Hormone (FSH) Levels After Multiple Dosing of a Recombinant Human FSH (FE 999049) in Healthy Women | Characterisation of Population Pharmacokinetics and Endogenous Follicle-Stimulating Hormone (FSH) Levels After Multiple Dosing of a Recombinant Human FSH (FE 999049) in Healthy Women Abstract Abstract Objective The aim of this study was to characterise the population pharmacokinetics of FE 999049, a novel recombinant h... |
PMC12660502 | core_pubmed_pmc | Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear | Intratympanic dexamethasone microcrystals/lidocaine‐loaded PLGA non‐spherical microparticles for local drug delivery to the inner ear Abstract Abstract Background Sudden sensorineural hearing loss (SSNHL), often associated with tinnitus, significantly impacts individuals' quality of life. Current treatments, such as fr... |
PMC5064742 | core_pubmed_pmc | Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [ 13 C 8 ]‐evacetrapib as a tracer | Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [ 13 C 8 ]‐evacetrapib as a tracer Abstract This open‐label, single‐period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administrat... |
PMC11755472 | core_pubmed_pmc | The Pharmacokinetic Changes in Cystic Fibrosis Patients Population: Narrative Review | The Pharmacokinetic Changes in Cystic Fibrosis Patients Population: Narrative Review Abstract Abstract Cystic fibrosis (CF) is a rare genetic disorder commonly affecting multiple organs such as the lungs, pancreas, liver, kidney, and intestine. Our search focuses on the pathophysiological changes that affect the drugs’... |
PMC10683027 | core_pubmed_pmc | Discovery of tert -Butyl Ester Based 6-Diazo-5-oxo- l -norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery | Discovery of tert -Butyl Ester Based 6-Diazo-5-oxo- l -norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery Abstract The glutamine antagonist 6-diazo-5-oxo- l -norleucine (DON) exhibits remarkable anticancer efficacy; however, its therapeutic potential is hindered by its toxicity to gastrointestinal ... |
PMC8965223 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses | Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses Abstract Abstract Background The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols. Hypothesis and Objectives Administration of gabapentin at 40 and 120 mg/kg PO ... |
PMC5934980 | core_pubmed_pmc | Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets | Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets Abstract Abstract Multidrug binding and transport by the ATP-binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic profiles o... |
PMC12618412 | core_pubmed_pmc | Population Pharmacokinetic Analysis of Balcinrenone in Healthy Participants and Participants with Heart Failure and Chronic Kidney Disease | Population Pharmacokinetic Analysis of Balcinrenone in Healthy Participants and Participants with Heart Failure and Chronic Kidney Disease Abstract Abstract Background and Objective Balcinrenone is a novel mineralocorticoid receptor modulator which, based on preclinical data, maintains cardio-renal benefits without inc... |
PMC12856346 | core_pubmed_pmc | Long-term follow-up of zevor-cel in patients with relapsed/refractory multiple myeloma ∗ | Long-term follow-up of zevor-cel in patients with relapsed/refractory multiple myeloma ∗ Abstract Key Points • At ∼5-year follow-up, objective response rate with zevor-cel was 100%, and 78.6% patients achieved complete or better response. • No grade ≥3 cytokine release syndrome, grade ≥3 neurotoxicity, or other delayed... |
PMC12621395 | core_pubmed_pmc | Analgesic and sedative drug dosing in critically ill patients with Acute Kidney Injury undergoing different modalities of Kidney Replacement Therapy | Analgesic and sedative drug dosing in critically ill patients with Acute Kidney Injury undergoing different modalities of Kidney Replacement Therapy Abstract Critically ill patients frequently require analgesic and sedative medications to manage pain, agitation, and the stress associated with their condition. The onset... |
PMC11489133 | core_pubmed_pmc | Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non‐human primate studies and clinical trials | Obicetrapib exhibits favorable physiochemical and pharmacokinetic properties compared to previous cholesteryl ester transfer protein inhibitors: An integrated summary of results from non‐human primate studies and clinical trials Abstract Abstract Anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor previo... |
PMC11771128 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients | Pharmacokinetics and pharmacodynamics of ciprofol after continuous infusion in elderly patients Abstract Abstract Background Ciprofol, a novel intravenous anesthetic, which has primarily been used for the induction and maintenance of general anesthesia in adults, is characterized by rapid onset, short duration of actio... |
PMC4232039 | core_pubmed_pmc | Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients | Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients Abstract Abstract This study aimed to evaluate the change in the pharmacokinetics (PK) of cyclosporine in the non-steady-state period in the first week after renal transplantation; the factors influencing this change,... |
PMC8240971 | core_pubmed_pmc | Electrosteric stealth Rivastigmine loaded liposomes for brain targeting: preparation, characterization, ex vivo , bio-distribution and in vivo pharmacokinetic studies | Electrosteric stealth Rivastigmine loaded liposomes for brain targeting: preparation, characterization, ex vivo , bio-distribution and in vivo pharmacokinetic studies Abstract Abstract Being one of the highly effective drugs in treatment of Alzheimer’s disease, Rivastigmine brain targeting is highly demandable, therefo... |
PMC11771590 | core_pubmed_pmc | Time Course of Reversal of Fentanyl‐Induced Respiratory Depression in Healthy Subjects by Intramuscular Nalmefene and Intramuscular and Intranasal Naloxone | Time Course of Reversal of Fentanyl‐Induced Respiratory Depression in Healthy Subjects by Intramuscular Nalmefene and Intramuscular and Intranasal Naloxone Abstract Abstract The increase in opioid overdose deaths, particularly involving potent, long‐acting synthetic opioids, has led to calls for stronger, longer‐acting... |
PMC6260118 | core_pubmed_pmc | Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban | Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban Abstract Summary Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag... |
PMC6890626 | core_pubmed_pmc | Are Standard Doses of Renally-Excreted Antiretrovirals in Older Patients Appropriate: A PBPK Study Comparing Exposures in the Elderly Population With Those in Renal Impairment | Are Standard Doses of Renally-Excreted Antiretrovirals in Older Patients Appropriate: A PBPK Study Comparing Exposures in the Elderly Population With Those in Renal Impairment Abstract Abstract Background and Objectives The elderly population receives the majority of prescription drugs but are usually excluded from Pha... |
PMC12408551 | core_pubmed_pmc | From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health | From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health Abstract Abstract Tetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine Ligusticum wallichii ( Chuanxiong) ,... |
PMC6720094 | core_pubmed_pmc | Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats | Comparative pharmacokinetics of oxyresveratrol alone and in combination with piperine as a bioenhancer in rats Abstract Background Oxyresveratrol is a major bioactive component derived from the heartwood of Artocarpus lacucha . This compound exerts several biological activities, including neuroprotective effects in vit... |
PMC8648015 | core_pubmed_pmc | Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles | Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles Abstract Abstract Context As an inhibitor cytochrome P450 family 2 subfamily C polypeptide 8 (CYP2C8), quercetin is a naturally occurring flavonoid with its glycosides consumed at least 100 mg per day in food. However, it is s... |
PMC10912040 | core_pubmed_pmc | CD19-CAR-DNT cells (RJMty19) in patients with relapsed or refractory large B-cell lymphoma: a phase 1, first-in-human study | CD19-CAR-DNT cells (RJMty19) in patients with relapsed or refractory large B-cell lymphoma: a phase 1, first-in-human study Abstract Summary Background Current approved chimeric antigen receptor (CAR) T-cell products are autologous cell therapies that are costly and poorly accessible to patients. We aimed to evaluate t... |
PMC4345959 | core_pubmed_pmc | Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease | Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease Abstract Aims To establish the dose−response for pharmacodynamics (bronchodilatation), safety and pharmacokinetics for a nebulized formulation of the long acting mu... |
PMC9421621 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study | Pharmacokinetic and pharmacodynamic profiles of a novel phospholipid-aspirin complex liquid formulation and low dose enteric-coated aspirin: results from a prospective, randomized, crossover study Abstract Abstract Low dose enteric-coated aspirin (EC-ASA) is routinely used for secondary cardiovascular event prevention.... |
PMC9580807 | core_pubmed_pmc | Computational Models for Diagnosing and Treating Endometriosis | Computational Models for Diagnosing and Treating Endometriosis Abstract Abstract Endometriosis is a common but poorly understood disease. Symptoms can begin early in adolescence, with menarche, and can be debilitating. Despite this, people often suffer several years before being correctly diagnosed and adequately treat... |
PMC10119371 | core_pubmed_pmc | A Mouse Model to Test Novel Therapeutics for Parkinson’s Disease: an Update on the Thy1-aSyn (“line 61”) Mice | A Mouse Model to Test Novel Therapeutics for Parkinson’s Disease: an Update on the Thy1-aSyn (“line 61”) Mice Abstract Development of neuroprotective therapeutics for Parkinson’s disease (PD) is facing a lack of translation from pre-clinical to clinical trials. One strategy for improvement is to increase predictive val... |
PMC4302124 | core_pubmed_pmc | Modelling chemotherapy effects on granulopoiesis | Modelling chemotherapy effects on granulopoiesis Abstract Abstract Background Although the growth-factor G-CSF is widely used to prevent granulotoxic side effects of cytotoxic chemotherapies, its optimal use is still unknown since treatment outcome depends on many parameters such as dosing and timing of chemotherapies,... |
PMC3102616 | core_pubmed_pmc | Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches | Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches Abstract Abstract Background Indacaterol is a once-daily long-acting inhaled β 2 -agonist indicated for maintenance treatment of moderate-to-severe chronic obstructive... |
PMC9618653 | core_pubmed_pmc | Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin | Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin Abstract The successful treatment of breast cancer is hampered by toxicity to normal cells, impaired drug accumulation at the tumor site, and multidrug resistance. We designed a novel multifunctional liposome, CUR-DTX-L, to co-deliv... |
PMC7179577 | core_pubmed_pmc | An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment | An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment Abstract Treating malaria in HIV-coinfected individuals should consider potential drug-drug interactions. Artemether-lumefantrine is the most widely recommend... |
PMC9685553 | core_pubmed_pmc | Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants | Comparative pharmacokinetics of new curcumin preparations and evidence for increased bioavailability in healthy adult participants Abstract Abstract Objective: Theracurmin, which contains the curcumin composition, CR-033P, has been demonstrated to be highly bioavailable. To compare the pharmacokinetics of the three com... |
PMC9469693 | core_pubmed_pmc | Exposure‐response relationships of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis | Exposure‐response relationships of etrolizumab in patients with moderately‐to‐severely active ulcerative colitis Abstract Abstract Etrolizumab is an IgG1‐humanized monoclonal anti‐β7 integrin antibody. Phase III trials with induction and/or maintenance phases were conducted in patients with moderately‐to‐severely activ... |
PMC3743526 | core_pubmed_pmc | Pharmacodynamics of vancomycin in elderly patients aged 75 years or older with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia | Pharmacodynamics of vancomycin in elderly patients aged 75 years or older with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia Abstract Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are associated with significant mortality and health care costs. To improve tr... |
PMC10968602 | core_pubmed_pmc | Nephrotic Syndrome: From Pathophysiology to Novel Therapeutic Approaches | Nephrotic Syndrome: From Pathophysiology to Novel Therapeutic Approaches Abstract Abstract Nephrotic edema stands out as one of the most common complications of nephrotic syndrome. The effective management of hypervolemia is paramount in addressing this condition. Initially, “the underfill hypothesis” suggested that pr... |
PMC9402490 | core_pubmed_pmc | Pharmacokinetic Assessment and Treatment Effect of Lusutrombopag in Child–Pugh Class C Patients: Review of Patient Data from Two Clinical Studies and Post-Marketing Surveillance | Pharmacokinetic Assessment and Treatment Effect of Lusutrombopag in Child–Pugh Class C Patients: Review of Patient Data from Two Clinical Studies and Post-Marketing Surveillance Abstract Introduction Patients with thrombocytopenia and chronic liver disease are at increased risk of bleeding during invasive procedures du... |
PMC11123365 | core_pubmed_pmc | Evaluation of the Metabolite Profile of Fish Oil Omega-3 Fatty Acids (n-3 FAs) in Micellar and Enteric-Coated Forms—A Randomized, Cross-Over Human Study | Evaluation of the Metabolite Profile of Fish Oil Omega-3 Fatty Acids (n-3 FAs) in Micellar and Enteric-Coated Forms—A Randomized, Cross-Over Human Study Abstract Abstract This study evaluated the differences in the metabolite profile of three n-3 FA fish oil formulations in 12 healthy participants: (1) standard softgel... |
PMC4674516 | core_pubmed_pmc | Potentially Inappropriate Medications in the Elderly in Korean Long-Term Care Facilities | Potentially Inappropriate Medications in the Elderly in Korean Long-Term Care Facilities Abstract Abstract Background Elderly residents of long-term care facilities are more vulnerable to being prescribed inappropriate medications because of the high incidence of co-medication in this population resulting from the pres... |
PMC6155221 | core_pubmed_pmc | A UPLC-MS/MS Method for Simultaneous Determination of Free and Total Forms of a Phenolic Acid and Two Flavonoids in Rat Plasma and Its Application to Comparative Pharmacokinetic Studies of Polygonum capitatum Extract in Rats | A UPLC-MS/MS Method for Simultaneous Determination of Free and Total Forms of a Phenolic Acid and Two Flavonoids in Rat Plasma and Its Application to Comparative Pharmacokinetic Studies of Polygonum capitatum Extract in Rats Abstract Abstract The principal active constituents of Polygonum capitatum are phenolic acids a... |
PMC6658739 | core_pubmed_pmc | Sequential Open-Label Study of the Safety, Tolerability, and Pharmacokinetic Interactions between Dihydroartemisinin-Piperaquine and Mefloquine in Healthy Thai Adults | Sequential Open-Label Study of the Safety, Tolerability, and Pharmacokinetic Interactions between Dihydroartemisinin-Piperaquine and Mefloquine in Healthy Thai Adults Abstract Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and morta... |
PMC6697719 | core_pubmed_pmc | Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development | Impact of mammalian cell culture conditions on monoclonal antibody charge heterogeneity: an accessory monitoring tool for process development Abstract Recombinant monoclonal antibodies are predominantly produced in mammalian cell culture bioprocesses. Post-translational modifications affect the micro-heterogeneity of t... |
PMC5351006 | core_pubmed_pmc | Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage | Modeling and Experimental Studies of Obeticholic Acid Exposure and the Impact of Cirrhosis Stage Abstract Obeticholic acid (OCA), a semisynthetic bile acid, is a selective and potent farnesoid X receptor (FXR) agonist in development for the treatment of chronic nonviral liver diseases. Physiologic pharmacokinetic model... |
PMC5023160 | core_pubmed_pmc | Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial | Efficacy and Safety of AmBisome in Combination with Sodium Stibogluconate or Miltefosine and Miltefosine Monotherapy for African Visceral Leishmaniasis: Phase II Randomized Trial Abstract Background SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful a... |
PMC11946702 | core_pubmed_pmc | Physicochemical Characterization and Oral Bioavailability of Curcumin–Phospholipid Complex Nanosuspensions Prepared Based on Microfluidic System | Physicochemical Characterization and Oral Bioavailability of Curcumin–Phospholipid Complex Nanosuspensions Prepared Based on Microfluidic System Abstract Background : Curcumin has been proved to have promising prospects in the fields of anti-inflammation, antibacterial, anti-oxidation, and neuroprotection. However, its... |
PMC10950984 | core_pubmed_pmc | Safety and pharmacokinetics of imaradenant (AZD4635) in Japanese patients with advanced solid malignancies: a phase I, open-label study | Safety and pharmacokinetics of imaradenant (AZD4635) in Japanese patients with advanced solid malignancies: a phase I, open-label study Abstract Abstract Purpose Imaradenant is a novel potent and selective adenosine A2A receptor antagonist that is hypothesized to reduce immune suppression in the tumor microenvironment.... |
PMC11420247 | core_pubmed_pmc | A sub-pharmacological test dose does not predict individual docetaxel exposure in prostate cancer patients | A sub-pharmacological test dose does not predict individual docetaxel exposure in prostate cancer patients Abstract Abstract Purpose Docetaxel is a cytotoxic drug used for first-line treatment of various malignancies. It has a narrow therapeutic index and shows wide interpatient variability in clearance and toxicity. T... |
PMC9979628 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19 | Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19 Abstract Introduction In the randomized double-blind placebo-controlled CounterCOVID study, oral imatinib treatment conferred a positive clinical outcome and a signal for reduced mortality in COVID-19 patients. High c... |
PMC12626027 | core_pubmed_pmc | A Review Vancomycin Role in Gram Positive Biofilm-Associated Infections: Challenges and Emerging Solutions | A Review Vancomycin Role in Gram Positive Biofilm-Associated Infections: Challenges and Emerging Solutions Abstract Abstract Biofilm-associated infections pose a significant challenge in clinical settings due to their increased resistance to antibiotics and evasion of host immune responses. These infections are respons... |
PMC3859605 | core_pubmed_pmc | Genetic and Non-Genetic Determinants of Raltegravir Penetration into Cerebrospinal Fluid: A Single Arm Pharmacokinetic Study | Genetic and Non-Genetic Determinants of Raltegravir Penetration into Cerebrospinal Fluid: A Single Arm Pharmacokinetic Study Abstract Abstract Background Antiretroviral drugs vary in their central nervous system penetration, with better penetration possibly conferring neurocognitive benefit during human immunodeficienc... |
PMC5297975 | core_pubmed_pmc | Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects | Pharmacokinetic Effects of Isavuconazole Coadministration With the Cytochrome P450 Enzyme Substrates Bupropion, Repaglinide, Caffeine, Dextromethorphan, and Methadone in Healthy Subjects Abstract Abstract This report describes phase 1 clinical trials performed to assess interactions of oral isavuconazole at the clinica... |
PMC9834611 | core_pubmed_pmc | Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism | Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism Abstract Abstract Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to... |
PMC10050909 | core_pubmed_pmc | Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis | Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis Abstract Background Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinami... |
PMC10983022 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose‐escalation phase I study | Pharmacokinetics, pharmacodynamics, and safety of frunexian in healthy Chinese volunteer adults: A randomized dose‐escalation phase I study Abstract Abstract The purpose of this study was to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of frunexian (formerly known as EP‐7041 and HSK36273) injec... |
PMC11163651 | core_pubmed_pmc | Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma | Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma Abstract Abstract Background Advanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer for which long-term survival rates are abysmal, though immunotherapies are showing potential. Not yet clin... |
PMC3876315 | core_pubmed_pmc | Sedative Dosing of Propofol for Treatment of Migraine Headache in the Emergency Department: A Case Series | Sedative Dosing of Propofol for Treatment of Migraine Headache in the Emergency Department: A Case Series Abstract Introduction: Migraine headaches requiring an emergency department visit due to failed outpatient rescue therapy present a significant challenge in terms of length of stay (LOS) and financial costs. Propof... |
PMC9548544 | core_pubmed_pmc | Population pharmacokinetic model of vancomycin in postoperative neurosurgical patients | Population pharmacokinetic model of vancomycin in postoperative neurosurgical patients Abstract Objective: Vancomycin is commonly used in postoperative neurosurgical patients for empirical anti-infective treatment due to the low success rate of bacterial culture in cerebrospinal fluid (about 20%) and the high mortality... |
PMC4370683 | core_pubmed_pmc | Pharmacokinetics, safety, and efficacy of APF530 (extended-release granisetron) in patients receiving moderately or highly emetogenic chemotherapy: results of two Phase II trials | Pharmacokinetics, safety, and efficacy of APF530 (extended-release granisetron) in patients receiving moderately or highly emetogenic chemotherapy: results of two Phase II trials Abstract Background Despite advances with new therapies, a significant proportion of patients (>30%) suffer delayed-onset chemotherapy-induce... |
PMC8842656 | core_pubmed_pmc | The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats | The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats Abstract Purpose CMC 2.24, a chemically modified curcumin, was developed as a novel, pleiotropic MMP-inhibitor to treat various inflammatory/collagenolytic diseases including periodontitis. To date, this compound has shown e... |
PMC11635537 | core_pubmed_pmc | Drug Therapy-related Problems Detected by Clinical Pharmacists in a Closed Loop Medication Management; A Cross-sectional Study in UAE | Drug Therapy-related Problems Detected by Clinical Pharmacists in a Closed Loop Medication Management; A Cross-sectional Study in UAE Abstract Abstract Introduction: Drug therapy-related problems (DTRP) can lead to avoidable negative health consequences, particularly during hospital admissions. This study aimed to asse... |
PMC7615677 | core_pubmed_pmc | DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex | DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex Abstract New drugs for visceral leishmaniasis that are safe, low cost and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new chemical entities with nove... |
PMC8518427 | core_pubmed_pmc | Benefit‐Risk Assessment of Off‐Label Drug Use in Children: The Bravo Framework | Benefit‐Risk Assessment of Off‐Label Drug Use in Children: The Bravo Framework Abstract Abstract A drug is granted a license for use after a thorough assessment of risks and benefits based on high‐quality scientific proof of its efficacy and safety. Many drugs that are relevant to children are not licensed for use in t... |
PMC4225328 | core_pubmed_pmc | A clinical and pharmacokinetic study of the combination of etravirine plus raltegravir in HIV patients with expanded intolerance or resistance | A clinical and pharmacokinetic study of the combination of etravirine plus raltegravir in HIV patients with expanded intolerance or resistance Abstract Introduction The combination of etravirine (ETR) plus raltegravir (RAL) could be an option for HIV patients with resistance, intolerance or important interactions with ... |
PMC11634579 | core_pubmed_pmc | Network pharmacology, experimental validation and pharmacokinetics integrated strategy to reveal pharmacological mechanism of goutengsan on methamphetamine dependence | Network pharmacology, experimental validation and pharmacokinetics integrated strategy to reveal pharmacological mechanism of goutengsan on methamphetamine dependence Abstract Background Goutengsan (GTS) is a traditional Chinese medicine formula that can improve multiple nervous system diseases, such as methamphetamine... |
PMC12616239 | core_pubmed_pmc | Tarlatamab Exposure–Efficacy and Exposure–Safety Relationships to Inform Dose Selection in Patients with Small Cell Lung Cancer | Tarlatamab Exposure–Efficacy and Exposure–Safety Relationships to Inform Dose Selection in Patients with Small Cell Lung Cancer Abstract Abstract Purpose: Tarlatamab is a first-in-class, half-life extended bispecific T-cell engager immunotherapy targeting delta-like ligand 3, currently approved for the treatment of adu... |
PMC10879373 | core_pubmed_pmc | A Randomized, Open-Label Study Conducted to Evaluate the Bioequivalence of Pegfilgrastim-cbqv On-Body Injector Versus Prefilled Syringe in Healthy Male Participants | A Randomized, Open-Label Study Conducted to Evaluate the Bioequivalence of Pegfilgrastim-cbqv On-Body Injector Versus Prefilled Syringe in Healthy Male Participants Abstract Introduction To help prevent febrile neutropenia, pegfilgrastim-cbqv (UDENYCA ® ; Coherus BioSciences), a pegfilgrastim (NEULASTA ® ; Amgen) biosi... |
PMC9439991 | core_pubmed_pmc | Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain–Barré Syndrome | Population Pharmacokinetic Modelling of Intravenous Immunoglobulin Treatment in Patients with Guillain–Barré Syndrome Abstract Abstract Background and Objective Intravenous immunoglobulin (IVIg) at a standard dosage is the treatment of choice for Guillain–Barré syndrome. The pharmacokinetics, however, is highly variabl... |
PMC8529019 | core_pubmed_pmc | Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses | Evaluation of Natalizumab Pharmacokinetics and Pharmacodynamics: Toward Individualized Doses Abstract Background: Plasma concentration of natalizumab falls above the therapeutic threshold in many patients who, therefore, receive more natalizumab than necessary and have higher risk of progressive multifocal leukoencepha... |
PMC12440994 | core_pubmed_pmc | Advances of paeoniflorin in depression: the molecular mechanism and formula application | Advances of paeoniflorin in depression: the molecular mechanism and formula application Abstract Abstract Paeoniflorin (PF) is widely present in species of the Paeonia genus. In recent years, numerous preclinical studies have shown that PF has preventive and therapeutic effects on various neurological diseases, particu... |
PMC12821564 | core_pubmed_pmc | First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults | First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults Abstract Abstract Fibrodysplasia ossificans progressiva is a rare, progressive autosomal dominant genetic disease caused by an activin receptor‐like kinase 2 (ALK2) mutation with a n... |
PMC7448909 | core_pubmed_pmc | Pharmacokinetics and tissue residue of enrofloxacin in healthy, Eimeria -infected broiler chickens and those pre-treated with amprolium and toltrazuril | Pharmacokinetics and tissue residue of enrofloxacin in healthy, Eimeria -infected broiler chickens and those pre-treated with amprolium and toltrazuril Abstract ABSTRACT The pharmacokinetics of enrofloxacin was compared in healthy chickens, Eimeria infected chickens and in Eimeria infected chickens pre-treated with amp... |
PMC10930379 | core_pubmed_pmc | A Systematic Review of Clozapine Concentration–Dose Ratio from Therapeutic Drug Monitoring Studies in Children and Adolescents Treated with Clozapine for Mental Disorders | A Systematic Review of Clozapine Concentration–Dose Ratio from Therapeutic Drug Monitoring Studies in Children and Adolescents Treated with Clozapine for Mental Disorders Abstract Abstract Background: Therapeutic drug monitoring of clozapine in children and adolescents has received insufficient attention. Calculation o... |
PMC4226160 | core_pubmed_pmc | Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development | Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development Abstract Abstract The empirical hypothesis generation and testing approach to pharmaceutical research and development (R&D), and biomedical research has proven very effective over the last half-cen... |
PMC7973531 | core_pubmed_pmc | Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers | Confirmation of the cardiac safety of nolasiban in a randomised cohort of healthy female volunteers Abstract Abstract Nolasiban is an orally active oxytocin receptor antagonist being developed to increase the efficiency of assisted reproductive technologies. This study evaluated the pharmacokinetics, pharmacodynamics, ... |
PMC7034090 | core_pubmed_pmc | Drug-interactive mPEG- b -PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel | Drug-interactive mPEG- b -PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel Abstract Abstract Docetaxel (DTX) is one of the most promising chemotherapeutic agents for a variety of solid tumors. However, the clinical efficacy of the marketed formulation, Taxotere ® , is limited due to its ... |
PMC8188985 | core_pubmed_pmc | Direct Oral Anticoagulants: From Randomized Clinical Trials to Real-World Clinical Practice | Direct Oral Anticoagulants: From Randomized Clinical Trials to Real-World Clinical Practice Abstract Abstract Direct oral anticoagulants (DOACs) are a more manageable alternative than vitamin K antagonists (VKAs) to prevent stroke in patients with nonvalvular atrial fibrillation and to prevent and treat venous thromboe... |
PMC11936838 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study | Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of ALXN1820 (Tarperprumig) in Healthy Adults: Results of a Phase I Study Abstract ABSTRACT Properdin is an endogenous positive regulator of the complement alternative pathway (AP). Tarperprumig (ALXN1820), a novel humanized bispecific antibody... |
PMC5034697 | core_pubmed_pmc | Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis | Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis Abstract This study aimed to derive quantitative abundance values for key hepatic transporters suitable for in vitro–in vivo extrapolation within a physiologically based pharmacokinetic modeling framework. A meta-analysis was performed whereby data on abu... |
PMC4147055 | core_pubmed_pmc | Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain | Diurnal Variation in P-glycoprotein-Mediated Transport and Cerebrospinal Fluid Turnover in the Brain Abstract Nearly all bodily processes exhibit circadian rhythmicity. As a consequence, the pharmacokinetic and pharmacodynamic properties of a drug may also vary with time of day. The objective of this study was to inves... |
PMC6628362 | core_pubmed_pmc | A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4- d ]Pyrimidine Dual Src/P-Glycoprotein Inhibitor | A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4- d ]Pyrimidine Dual Src/P-Glycoprotein Inhibitor Abstract Abstract Overexpression of P-glycoprotein (P-gp) and other ATP-binding cassette (ABC) transporters in multidrug resistant (MDR) cancer cells is ... |
PMC3787887 | core_pubmed_pmc | Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics | Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics Abstract Abstract Phospho-sulindac (PS) is a safe sulindac derivative with promising anticancer efficacy in colon cancer. We evaluated whether its combination with curcumin could enhance the efficacy in the ... |
PMC12298344 | core_pubmed_pmc | Advances in Liposomal Drug Delivery: Multidirectional Perspectives on Overcoming Biological Barriers | Advances in Liposomal Drug Delivery: Multidirectional Perspectives on Overcoming Biological Barriers Abstract Abstract Liposomes represent a cornerstone of modern drug delivery systems due to their unique structural and physicochemical characteristics. Extensive research has refined their formulation, stability, and ta... |
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