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PMC4910469 | core_pubmed_pmc | Therapeutic monitoring of amikacin and gentamicin in critically and noncritically ill patients | Therapeutic monitoring of amikacin and gentamicin in critically and noncritically ill patients Abstract Abstract Objective: Therapeutic drug monitoring (TDM) enables individualization in the treatment to optimize clinical benefit and minimize drugs' side effects. Critically ill septic patients represent a challenge for... |
PMC9759570 | core_pubmed_pmc | Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism | Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism Abstract Little is known about the impact of morphological disorders in distinct zones on metabolic zonation. It was described recently that periportal fibrosis did affect the expression of CYP proteins, a set of pericentrally locat... |
PMC10787204 | core_pubmed_pmc | Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330 | Bridging population pharmacokinetic and semimechanistic absorption modeling of APX3330 Abstract Abstract APX3330 ((2E)‐2‐[(4,5‐dimethoxy‐2‐methyl‐3,6‐dioxo‐1,4‐cyclohexadien‐1‐yl)methylene]‐undecanoic acid), a selective inhibitor of APE1/Ref‐1, has been investigated in treatment of hepatitis, cancer, diabetic retinopat... |
PMC6972567 | core_pubmed_pmc | Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail | Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail Abstract Abstract The aim of this study was to characterize the effects of upadacitinib, a Janus kinase 1 inhibitor, on in vivo activity of different cytochr... |
PMC12202309 | core_pubmed_pmc | Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice | Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice Abstract Abstract Background A detailed understanding of alterations in olanzapine pharmacokinetics during acute inflammatory states, associated wi... |
PMC9357092 | core_pubmed_pmc | Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases | Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases Abstract Abstract Purpose: This study evaluated the central nervous system (CNS) pharmacokinetics and target engagement of lapatinib, neratinib, ... |
PMC10031315 | core_pubmed_pmc | Effect of participation of typical clinical pharmacists in patient medication in ICUs with different approaches: An investigation and case analysis | Effect of participation of typical clinical pharmacists in patient medication in ICUs with different approaches: An investigation and case analysis Abstract Abstract Purpose To investigate and study the impact on patient recovery of pharmacists’ participation in the medication guidance and intervention of patients in i... |
PMC12501467 | core_pubmed_pmc | Clinical therapeutics in feline medicine: updates for old and new drugs | Clinical therapeutics in feline medicine: updates for old and new drugs Abstract Abstract Practical relevance: Over the past 10 years, feline medicine has significantly advanced through the addition of new pharmaceuticals and alternative formulations available for cats, as well as improvements in the knowledge about ex... |
PMC4467398 | core_pubmed_pmc | Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor | Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor Abstract ST7612AA1 (property of Sigma-Tau), a thioacetate-ω (γ-lactam amide) derivative, is a potent, second generation, oral pan-histone deacetylase inhibitor (HDACi). Aim of the study was to assess the... |
PMC10221009 | core_pubmed_pmc | Unknown Organofluorine Mixtures in U.S. Adult Serum:Contribution from Pharmaceuticals? | Unknown Organofluorine Mixtures in U.S. Adult Serum:Contribution from Pharmaceuticals? Abstract Abstract Organofluorines occur in human serum as complex mixtures of known and unidentified compounds. Human biomonitoring traditionally uses targeted analysis to measure the presence of known and quantifiable per- and polyf... |
PMC8624447 | core_pubmed_pmc | Model-Based Approach for Designing an Efficient Bioequivalence Study for Highly Variable Drugs | Model-Based Approach for Designing an Efficient Bioequivalence Study for Highly Variable Drugs Abstract Abstract The statistical procedures as outlined by the European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) guidelines for bioequivalence testing of highly variable drugs (HVDs) are co... |
PMC12915198 | core_pubmed_pmc | Pharmacokinetics, safety and preliminary efficacy study of montelukast in critically ill infants with developing bronchopulmonary dysplasia (PRISM) | Pharmacokinetics, safety and preliminary efficacy study of montelukast in critically ill infants with developing bronchopulmonary dysplasia (PRISM) Abstract Abstract Bronchopulmonary dysplasia (BPD) is an inflammatory disease stemming from premature birth and iatrogenic lung injury. BPD is relatively common and frequen... |
PMC8107818 | core_pubmed_pmc | The Mechanism of Lavender Essential Oil in the Treatment of Acute Colitis Based on “Quantity–Effect” Weight Coefficient Network Pharmacology | The Mechanism of Lavender Essential Oil in the Treatment of Acute Colitis Based on “Quantity–Effect” Weight Coefficient Network Pharmacology Abstract Abstract This study aimed to introduce a new weight coefficient combined with network pharmacology to predict the potential active components, action targets, and signal ... |
PMC5537312 | core_pubmed_pmc | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart | Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart Abstract The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. The present study investigated the effects of scutellarin against DOX-induced cardiotoxicity in rats using pha... |
PMC6712828 | core_pubmed_pmc | Laboratory School Protocol Mini-Review: Use of Direct Observational and Objective Measures to Assess ADHD Treatment Response Across the Lifespan | Laboratory School Protocol Mini-Review: Use of Direct Observational and Objective Measures to Assess ADHD Treatment Response Across the Lifespan Abstract Introduction The time of onset and the duration of treatment effect are important considerations in the choice of the medication to be prescribed in treating children... |
PMC10634021 | core_pubmed_pmc | Male contraception: narrative review of ongoing research | Male contraception: narrative review of ongoing research Abstract Background Since the release of the combined oral contraceptive pill in 1960, women have shouldered the burden of contraception and family planning. Over 60 years later, this is still the case as the only practical, effective contraceptive options availa... |
PMC6781309 | core_pubmed_pmc | Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators | Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators Abstract Loxoprofen (LOX) is a non-selective cyclooxygenase inhibitor that is widely used for the treatment of pain and inflammation caused by chronic and transitory conditions. Its alcoholic metabolites are formed by ca... |
PMC5458052 | core_pubmed_pmc | A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance | A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance Abstract K13 gene mutations are a primary marker of artemisinin resistance in Plasmodium falciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therapies, the cornerstone... |
PMC4782111 | core_pubmed_pmc | Results from a phase 1 study of nusinersen (ISIS-SMN Rx ) in children with spinal muscular atrophy | Results from a phase 1 study of nusinersen (ISIS-SMN Rx ) in children with spinal muscular atrophy Abstract Abstract Objective: To examine safety, tolerability, pharmacokinetics, and preliminary clinical efficacy of intrathecal nusinersen (previously ISIS-SMN Rx ), an antisense oligonucleotide designed to alter splicin... |
PMC6160928 | core_pubmed_pmc | Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry | Simultaneous Determination of Five Cytochrome P450 Probe Substrates and Their Metabolites and Organic Anion Transporting Polypeptide Probe Substrate in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Abstract Abstract A rapid and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) meth... |
PMC11415013 | core_pubmed_pmc | Patient-centric microsampling for abrocitinib pharmacokinetics: multiple-analytes assay bridging using Tasso device | Patient-centric microsampling for abrocitinib pharmacokinetics: multiple-analytes assay bridging using Tasso device Abstract Abstract Aim: The feasibility of using Tasso devices (Tasso-SST ® and Tasso + ) collecting capillary blood samples for measuring abrocitinib and its metabolites were evaluated, and assay concorda... |
PMC5411174 | core_pubmed_pmc | A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers | A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers Abstract Objectives DWP05195 is a transient receptor potential vanilloid 1 (TRPV1) antagonist developed for managing pain. The purpose of this study was to evaluate the phar... |
PMC10610259 | core_pubmed_pmc | Evaluating Sex Differences in Efficacy, Safety and Pharmacokinetics in Patients Treated with Cannabis by a Metered-Dose Inhaler | Evaluating Sex Differences in Efficacy, Safety and Pharmacokinetics in Patients Treated with Cannabis by a Metered-Dose Inhaler Abstract Abstract Background: Clinical studies on medical cannabis (MC) treatment have shown sex-related differences, including higher susceptibility to adverse events among women and greater ... |
PMC5306155 | core_pubmed_pmc | Multilevel pharmacokinetics-driven modeling of metabolomics data | Multilevel pharmacokinetics-driven modeling of metabolomics data Abstract Introduction Multilevel modeling is a quantitative statistical method to investigate variability and relationships between variables of interest, taking into account population structure and dependencies. It can be used for prediction, data reduc... |
PMC6139228 | core_pubmed_pmc | Rapid, Validated UPLC-MS/MS Method for Determination of Glibenclamide in Rat Plasma | Rapid, Validated UPLC-MS/MS Method for Determination of Glibenclamide in Rat Plasma Abstract Quick and specific bioanalytical methods are required for analyzing drugs in biological samples. A simple, quick, sensitive, and specific UPLC-MS/MS method was developed and validated for glibenclamide determination in plasma s... |
PMC10977476 | core_pubmed_pmc | A Single Ascending-Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Respiratory Stimulant ENA-001 | A Single Ascending-Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Respiratory Stimulant ENA-001 Abstract Background ENA-001 (formerly known as GAL-021) is a novel, first-in-class respiratory stimulant. Pharmacokinetic and pharmacodynamic properties, plus safety and tolerabil... |
PMC5874833 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of ( S )-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats | Pharmacokinetics and Pharmacodynamics of ( S )-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats Abstract The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of ( S )-ketoprofen following oral administration in a gout-type p... |
PMC9541882 | core_pubmed_pmc | Multi-component pharmacokinetic study of prunus mume fructus extract after oral administration in rats using UPLC-MS/MS | Multi-component pharmacokinetic study of prunus mume fructus extract after oral administration in rats using UPLC-MS/MS Abstract Abstract Prunus mume fructus (MF) is used in traditional Chinese medicine and food, as it exerts pharmacological effects, such as antibacterial, antioxidant, antitumour, thirst-relieving, and... |
PMC8579302 | core_pubmed_pmc | Assessment of the Utility of Physiologically-based Pharmacokinetic Model for prediction of Pharmacokinetics in Chinese and Japanese Populations | Assessment of the Utility of Physiologically-based Pharmacokinetic Model for prediction of Pharmacokinetics in Chinese and Japanese Populations Abstract Abstract The objective for the present analyses was to evaluate the utility of physiologically-based pharmacokinetic (PBPK) modeling for prediction of the pharmacokine... |
PMC12106086 | core_pubmed_pmc | Safety, efficacy, and immunogenicity of a novel IgG degrading enzyme (KJ103): results from two randomised, blinded, phase 1 clinical trials | Safety, efficacy, and immunogenicity of a novel IgG degrading enzyme (KJ103): results from two randomised, blinded, phase 1 clinical trials Abstract The approved intravenous adeno-associated virus (AAV) therapies are limited by the widespread prevalence of pre-existing anti-AAV antibodies in the general population, whi... |
PMC9943251 | core_pubmed_pmc | Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation | Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation Abstract Abstract The present research study limns the preparation of MNF loaded transethosomes (MNF-TE) to improve MNF solubility, bioava... |
PMC11261485 | core_pubmed_pmc | Les effets du variant CYP3A5*3 sur la pharmacocinétique du tacrolimus et le pronostic de transplantés rénaux tunisiens | Les effets du variant CYP3A5*3 sur la pharmacocinétique du tacrolimus et le pronostic de transplantés rénaux tunisiens Abstract RESUME Introduction: Le tacrolimus présente une variabilité pharmacocinétique interindividuelle et un index thérapeutique étroit. L’influence du single nucleotide polymorphism (SNP) CYP3A5 698... |
PMC9840549 | core_pubmed_pmc | Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of Hedyotis diffusa Willd in Liver Cancer | Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of Hedyotis diffusa Willd in Liver Cancer Abstract Abstract Purpose Hedyotis diffusa Willd (HDW) is one of the most well-known herbs used in the therapy of cancer. However, the potential mechanisms of its antiangiogenic effects ha... |
PMC6246693 | core_pubmed_pmc | The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer | The Histone H3 Lysine 4 Presenter WDR5 as an Oncogenic Protein and Novel Epigenetic Target in Cancer Abstract The histone H3 lysine 4 (H3K4) presenter WDR5 forms protein complexes with H3K4 methyltransferases MLL1-MLL4 and binding partner proteins including RBBP5, ASH2L, and DPY30, and plays a key role in histone H3K4 ... |
PMC9375538 | core_pubmed_pmc | Impact of genetic polymorphisms at the promoter area of IL-10 gene on tacrolimus level in Jordanian renal transplantation recipients | Impact of genetic polymorphisms at the promoter area of IL-10 gene on tacrolimus level in Jordanian renal transplantation recipients Abstract Background Tacrolimus is a widely used immunosuppressant that prevents solid organ transplant rejection. The pharmacokinetics of Tacrolimus show considerable varia - bility. Inte... |
PMC9506492 | core_pubmed_pmc | Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning | Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning Abstract One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the bloo... |
PMC11594044 | core_pubmed_pmc | Modification of B-Nor Steroids Mediated by Filamentous Fungus Fusarium culmorum : Focus on 15α-Hydroxylase Activity | Modification of B-Nor Steroids Mediated by Filamentous Fungus Fusarium culmorum : Focus on 15α-Hydroxylase Activity Abstract Abstract The metabolic activities of microorganisms to modify the chemical structures of organic compounds are an effective tool for the production of high-value steroidal drugs or active pharmac... |
PMC6434233 | core_pubmed_pmc | Cyclosporin population pharmacokinetics in pediatric refractory nephrotic syndrome based on real-world studies: Effects of body weight and spirolactone administration | Cyclosporin population pharmacokinetics in pediatric refractory nephrotic syndrome based on real-world studies: Effects of body weight and spirolactone administration Abstract Different models of population pharmacokinetics (PPK) of cyclosporin have been established in various populations. However, the cyclosporin PPK ... |
PMC6900894 | core_pubmed_pmc | Single-dose and Steady-state Pharmacokinetics of Vancomycin in Critically Ill Patients Admitted to Medical Intensive Care Unit of India | Single-dose and Steady-state Pharmacokinetics of Vancomycin in Critically Ill Patients Admitted to Medical Intensive Care Unit of India Abstract ABSTRACT Rationale Vancomycin remains the standard of care for gram-positive bacterial infections, though there are significant developments in newer antibacterial agents. Eff... |
PMC12072223 | core_pubmed_pmc | Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions | Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions Abstract ABSTRACT Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 a... |
PMC6084369 | core_pubmed_pmc | Bioequivalence and Safety of Twice‐Daily Sustained‐Release Paracetamol (Acetaminophen) Compared With 3‐ and 4‐Times‐Daily Paracetamol: A Repeat‐Dose, Crossover Pharmacokinetic Study in Healthy Volunteers | Bioequivalence and Safety of Twice‐Daily Sustained‐Release Paracetamol (Acetaminophen) Compared With 3‐ and 4‐Times‐Daily Paracetamol: A Repeat‐Dose, Crossover Pharmacokinetic Study in Healthy Volunteers Abstract Abstract Twice‐daily sustained‐release (SR) paracetamol (acetaminophen) offers convenient administration to... |
PMC6581757 | core_pubmed_pmc | VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle | VetCAST Method for Determination of the Pharmacokinetic-Pharmacodynamic Cut-Off Values of a Long-Acting Formulation of Florfenicol to Support Clinical Breakpoints for Florfenicol Antimicrobial Susceptibility Testing in Cattle Abstract Abstract The PK/PD cut-off (PK/PD CO ) value of florfenicol for calf pathogens was de... |
PMC10674159 | core_pubmed_pmc | Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study | Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study Abstract A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric ... |
PMC11222773 | core_pubmed_pmc | Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study | Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study Abstract Abstract Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any relat... |
PMC6783595 | core_pubmed_pmc | Pharmacokinetics and safety of tadalafil in a paediatric population with pulmonary arterial hypertension: A multiple ascending‐dose study | Pharmacokinetics and safety of tadalafil in a paediatric population with pulmonary arterial hypertension: A multiple ascending‐dose study Abstract Abstract Aims To evaluate the pharmacokinetics and safety of once‐daily (QD) tadalafil in paediatric patients with pulmonary arterial hypertension (PAH) to establish an appr... |
PMC10835503 | core_pubmed_pmc | Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants | Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL‐286, a novel retinoic acid receptor‐β agonist for treatment of spinal cord injury, in male healthy participants Abstract Abstract Aims KCL‐286 is an orally available agonist that activates the retinoic acid receptor (RAR) β2, a transcript... |
PMC9598571 | core_pubmed_pmc | Imaging Technologies for Cerebral Pharmacokinetic Studies: Progress and Perspectives | Imaging Technologies for Cerebral Pharmacokinetic Studies: Progress and Perspectives Abstract Pharmacokinetic assessment of drug disposition processes in vivo is critical in predicting pharmacodynamics and toxicology to reduce the risk of inappropriate drug development. The blood–brain barrier (BBB), a special physiolo... |
PMC8436259 | core_pubmed_pmc | Intranasal Corticosteroids: Topical Potency, Systemic Activity and Therapeutic Index | Intranasal Corticosteroids: Topical Potency, Systemic Activity and Therapeutic Index Abstract Abstract Intranasal corticosteroid (INCS) therapy is the preferred treatment option for allergic rhinitis (AR). Although all INCSs for the treatment of AR are considered safe and effective, differences in potency, molecular st... |
PMC6330697 | core_pubmed_pmc | Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies | Vaccination Guidelines for Patients With Immune-Mediated Disorders on Immunosuppressive Therapies Abstract Abstract Background: Patients with immune-mediated diseases on immunosuppressive therapies have more infectious episodes than healthy individuals, yet vaccination practices by physicians for this patient populatio... |
PMC5321813 | core_pubmed_pmc | Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics | Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics Abstract This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model Evaluation Group. Numerous tools are available... |
PMC6299220 | core_pubmed_pmc | Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA | Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA Abstract Cell wall biosynthesis inhibitors have proven highly effective for treating tuberculosis (TB). We discovered and validated members of the indazole sulfonamide class of small molecules as inhibitors of Mycobacterium tuberculosis KasA... |
PMC10877774 | core_pubmed_pmc | Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics | Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics Abstract Abstract Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clini... |
PMC7163375 | core_pubmed_pmc | Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients | Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients Abstract Aims Fanconi anaemia (FA) is a rare disorder characterized by progressive bone marrow failure that requires haematopoietic cell transplantation (HCT). Busulfan is used in conditioning r... |
PMC9003982 | core_pubmed_pmc | Plasma disappearance rate of albumin when infused as a 20% solution | Plasma disappearance rate of albumin when infused as a 20% solution Abstract Background The transcapillary leakage of albumin is increased by inflammation and major surgery, but whether exogenous albumin also disappears faster is unclear. Methods An intravenous infusion of 3 mL/kg of 20% albumin was given over 30 min t... |
PMC8197169 | core_pubmed_pmc | Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods | Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods Abstract Abstract Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to divers... |
PMC12452475 | core_pubmed_pmc | ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis | ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis Abstract ABSTRACT N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynami... |
PMC12207585 | core_pubmed_pmc | Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy | Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy Abstract Sepsis-induced coagulopathy (SIC) is a severe and frequent complication of sepsis, which is associated with high mortality in pa... |
PMC8003994 | core_pubmed_pmc | Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions | Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions Abstract Abstract With more than 90 approved drugs by 2020, therapeutic antibodies have played a central role in shifting the treatment landscape of many diseases, including autoimmune disorders and can... |
PMC6441979 | core_pubmed_pmc | Application of pharmacokinetic/pharmacodynamic analysis to evaluate the adequacy of antimicrobial therapy for pediatric acute otitis media in Spain before and after the introduction of the PCV7 vaccine | Application of pharmacokinetic/pharmacodynamic analysis to evaluate the adequacy of antimicrobial therapy for pediatric acute otitis media in Spain before and after the introduction of the PCV7 vaccine Abstract Objectives To evaluate, by applying pharmacokinetic/pharmacodynamic (PK/PD) analysis, if the change in antibi... |
PMC9025810 | core_pubmed_pmc | Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination | Interaction of Antifungal Drugs with CYP3A- and OATP1B-Mediated Venetoclax Elimination Abstract Abstract Venetoclax, a BCL-2 inhibitor used to treat certain hematological cancers, exhibits low oral bioavailability and high interpatient pharmacokinetic variability. Venetoclax is commonly administered with prophylactic a... |
PMC5655694 | core_pubmed_pmc | Pharmacology and Therapeutics Education in the European Union Needs Harmonization and Modernization: A Cross‐sectional Survey Among 185 Medical Schools in 27 Countries | Pharmacology and Therapeutics Education in the European Union Needs Harmonization and Modernization: A Cross‐sectional Survey Among 185 Medical Schools in 27 Countries Abstract Effective teaching in pharmacology and clinical pharmacology and therapeutics (CPT) is necessary to make medical students competent prescribers... |
PMC6588957 | core_pubmed_pmc | Molidustat for the treatment of renal anaemia in patients with non-dialysis-dependent chronic kidney disease: design and rationale of two phase III studies | Molidustat for the treatment of renal anaemia in patients with non-dialysis-dependent chronic kidney disease: design and rationale of two phase III studies Abstract Abstract Introduction Anaemia is a common complication of chronic kidney disease (CKD). Owing to the limitations of erythropoiesis-stimulating agents (ESAs... |
PMC8417017 | core_pubmed_pmc | Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting | Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting Abstract Abstract Background Iohexol plasma clearance-based glomerular filtration rate (GFR) determination provides an accurate method for renal function evaluation. This technique is incre... |
PMC4787342 | core_pubmed_pmc | Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma | Determination and Pharmacokinetic Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodis rhizoma Abstract Abstract Background: In traditional Chinese medicine, Atractylodis rhizoma is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. After be... |
PMC4112042 | core_pubmed_pmc | Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors | Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors Abstract Abstract Purpose Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme important in DNA repair. PARP-1 activation at points of DNA strand break results in poly(ADP-... |
PMC7289991 | core_pubmed_pmc | Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections | Population Pharmacokinetics and Limited Sampling Strategy for Therapeutic Drug Monitoring of Polymyxin B in Chinese Patients With Multidrug-Resistant Gram-Negative Bacterial Infections Abstract Abstract Polymyxin B is used as a last therapeutic option for the treatment of multidrug-resistant Gram-negative bacterial inf... |
PMC8928006 | core_pubmed_pmc | Efficacy of Losartan in Hospitalized Patients With COVID-19–Induced Lung Injury | Efficacy of Losartan in Hospitalized Patients With COVID-19–Induced Lung Injury Abstract Key Points Question What is the effect of losartan on lung injury in hospitalized patients with COVID-19? Findings In this randomized clinical trial in 205 patients with evidence of COVID-19–induced acute lung injury, angiotensin r... |
PMC5430436 | core_pubmed_pmc | [ 18 F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model | [ 18 F]tetrafluoroborate-PET/CT enables sensitive tumor and metastasis in vivo imaging in a sodium iodide symporter-expressing tumor model Abstract Abstract Cancer cell metastasis is responsible for most cancer deaths. Non-invasive in vivo cancer cell tracking in spontaneously metastasizing tumor models still poses a c... |
PMC11620486 | core_pubmed_pmc | Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination | Gentamicin concentration and acute kidney injury in term neonates treated for neonatal sepsis with gentamicin and ampicillin-cloxacillin combination Abstract ABSTRACT Gentamicin is widely used to treat neonatal infections caused by both Gram-negative and Gram-positive bacteria, and the WHO recommends its use while moni... |
PMC5760801 | core_pubmed_pmc | Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats | Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats Abstract The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Solanum lyratum Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration ... |
PMC11434290 | core_pubmed_pmc | Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1 H -1,2,4-Triazol-3-ylthio-conjugate of Prottremine | Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1 H -1,2,4-Triazol-3-ylthio-conjugate of Prottremine Abstract Abstract The novel antiparkinsonian agent PA-96 is the focus of our research. PA-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits in M... |
PMC12213583 | core_pubmed_pmc | Characterization and functional evaluation of JS207, a novel bispecific antibody against human PD-1 and VEGFA | Characterization and functional evaluation of JS207, a novel bispecific antibody against human PD-1 and VEGFA Abstract Introduction Cancer immunotherapy has been revolutionized by targeting PD-1 to restore antitumor T-cell activity and blocking VEGF to attenuate immunosuppressive tumor angiogenesis. While combining PD-... |
PMC12232335 | core_pubmed_pmc | Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024) | Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024) Abstract Abstract Objectives This study aimed to: (1) characterise the pharmacokinetics of GS‐441524 following intravenous (iv) ad... |
PMC7386737 | core_pubmed_pmc | Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos ( Hemidactylus frenatus ) after single-dose oral administration of enrofloxacin | Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos ( Hemidactylus frenatus ) after single-dose oral administration of enrofloxacin Abstract Highlights • No adverse reactions observed in geckos during oral dosing of enrofloxacin. • Ciprofloxacin contributed negligibly to total... |
PMC3994918 | core_pubmed_pmc | Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers ☆ | Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers ☆ Abstract Abstract Background Olmesartan is an angiotensin II receptor antagonist and is effective and well tolerated in the treatment of arterial hypertension. Probenecid is a well-established hypouricemic agent for ... |
PMC9082252 | core_pubmed_pmc | Four months of rifampicin monotherapy for latent tuberculosis infection in children | Four months of rifampicin monotherapy for latent tuberculosis infection in children Abstract Abstract Diagnosing and treating latent tuberculosis infection (LTBI) is an important part of efforts to combat tuberculosis (TB). The Korean guidelines for TB published in 2020 recommend 2 LTBI regimens for children and adoles... |
PMC9078534 | core_pubmed_pmc | Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats | Cytosolic β-glucosidase inhibition and renal blood flow suppression are leading causes for the enhanced systemic exposure of salidroside in hypoxic rats Abstract The promising benefits of salidroside (SAL) in alleviating high altitude sickness boost investigations on its pharmacokinetics and biological activity. Howeve... |
PMC11272083 | core_pubmed_pmc | Efficacy, Safety, and Pharmacokinetics by Body Mass Index Category in Phase 3/3b Long-Acting Cabotegravir Plus Rilpivirine Trials | Efficacy, Safety, and Pharmacokinetics by Body Mass Index Category in Phase 3/3b Long-Acting Cabotegravir Plus Rilpivirine Trials Abstract Abstract Background Cabotegravir plus rilpivirine (CAB + RPV) is a guideline-recommended long-acting (LA) injectable regimen for the maintenance of human immunodeficiency virus-1 (H... |
PMC9483253 | core_pubmed_pmc | Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines | Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines Abstract Abstract Traditional medicine has provided a basis for health care and disease treatment to Chinese people for millennia, and herbal medicines are regulated as drug products in China. Chinese herbal medicines have two feat... |
PMC12939196 | core_pubmed_pmc | Invasive Fungal Infections During Extracorporeal Membrane Oxygenation: A Case Series from Intensive Care Unit and Literature Review | Invasive Fungal Infections During Extracorporeal Membrane Oxygenation: A Case Series from Intensive Care Unit and Literature Review Abstract Background : Extracorporeal membrane oxygenation (ECMO) support is associated with potentially life-threatening complications, among which nosocomial infections play a significant... |
PMC8432874 | core_pubmed_pmc | Investigating myotoxicity following Australian red-bellied black snake ( Pseudechis porphyriacus ) envenomation | Investigating myotoxicity following Australian red-bellied black snake ( Pseudechis porphyriacus ) envenomation Abstract Abstract Background Myotoxicity is one of the common clinical manifestations of red-bellied black snake ( Pseudechis porphyriacus ) envenomation characterised by elevated creatine kinase (CK) concent... |
PMC6055619 | core_pubmed_pmc | Twice‐weekly ixazomib in combination with lenalidomide‐dexamethasone in patients with newly diagnosed multiple myeloma | Twice‐weekly ixazomib in combination with lenalidomide‐dexamethasone in patients with newly diagnosed multiple myeloma Abstract Summary Weekly ixazomib with lenalidomide‐dexamethasone (Rd) is feasible and has shown activity in newly diagnosed multiple myeloma ( NDMM ) patients. This phase 1/2 study ( NCT 01383928) eval... |
PMC8245892 | core_pubmed_pmc | Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study | Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study Abstract ABSTRACT Background Curcuminoids from turmeric rhizome have significant health benefits but low bioavailability. Objectives To assess the pharmacokinetics of a novel natural turmeric dried coll... |
PMC4624821 | core_pubmed_pmc | Evaluation of optimized bronchoalveolar lavage sampling designs for characterization of pulmonary drug distribution | Evaluation of optimized bronchoalveolar lavage sampling designs for characterization of pulmonary drug distribution Abstract Abstract Bronchoalveolar lavage (BAL) is a pulmonary sampling technique for characterization of drug concentrations in epithelial lining fluid and alveolar cells. Two hypothetical drugs with diff... |
PMC9192636 | core_pubmed_pmc | Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML | Adjunction of a fish oil emulsion to cytarabine and daunorubicin induction chemotherapy in high-risk AML Abstract The treatment of acute myeloid leukemia (AML) with unfavorable cytogenetics treatment remains a challenge. We previously established that ex vivo exposure of AML blasts to eicosapentaenoic acid (EPA), docos... |
PMC12903914 | core_pubmed_pmc | Development of an LC-MS/MS method for amantadine detection in human plasma using ZIF-8 as adsorbent and pharmacokinetic investigation | Development of an LC-MS/MS method for amantadine detection in human plasma using ZIF-8 as adsorbent and pharmacokinetic investigation Abstract In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative determination of amantadine in human plasma, w... |
PMC5587524 | core_pubmed_pmc | Effects of Food on the Pharmacokinetics of Omega-3-Carboxylic Acids in Healthy Japanese Male Subjects: A Phase I, Randomized, Open-label, Three-period, Crossover Trial | Effects of Food on the Pharmacokinetics of Omega-3-Carboxylic Acids in Healthy Japanese Male Subjects: A Phase I, Randomized, Open-label, Three-period, Crossover Trial Abstract Abstract Aims : Omega-3-carboxylic acids (OM3-CA) contain omega-3 free fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic aci... |
PMC11279629 | core_pubmed_pmc | Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors | Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors Abstract Abstract Optimized syntheses of ( E )-5-(2-ethoxyphenyl)- N -(3-(methylsulfonyl)allyl)-1 H -pyrazole-3-carboxamide (RA-0002034, 1 ), a promising antiviral cov... |
PMC8049919 | core_pubmed_pmc | Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor | Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor Abstract Prasugrel and ticagrelor are potent oral platelet P2Y 12 inhibitors and are recommended over clopidogrel in patients with acute coronary syndrome (ACS). Oral plate... |
PMC10674621 | core_pubmed_pmc | External Evaluation of Population Pharmacokinetics Models of Lithium in the Bipolar Population | External Evaluation of Population Pharmacokinetics Models of Lithium in the Bipolar Population Abstract Abstract Lithium has been used in the treatment of bipolar disorder for several decades. Treatment optimization is recommended for this drug, due to its narrow therapeutic range and a large pharmacokinetics (PK) vari... |
PMC12358301 | core_pubmed_pmc | Isavuconazole and Calcium Channel Blocker for Invasive Fungal Disease Accompanied With Hypertension: Evidence From the FAERS and PBPK/PD Model | Isavuconazole and Calcium Channel Blocker for Invasive Fungal Disease Accompanied With Hypertension: Evidence From the FAERS and PBPK/PD Model Abstract ABSTRACT Patients with invasive fungal disease (IFD) frequently present with hypertension, necessitating polypharmacy and increasing the risk of drug–drug interactions ... |
PMC8312158 | core_pubmed_pmc | Drug-Drug interaction among admitted patients at primary, district and referral hospitals’ medical wards in East Gojjam Zone, Amhara Regional State, Ethiopia | Drug-Drug interaction among admitted patients at primary, district and referral hospitals’ medical wards in East Gojjam Zone, Amhara Regional State, Ethiopia Abstract Abstract Objectives: This study was aimed to assess the type, prevalence, characteristics of drug interaction and factors associated from admitted patien... |
PMC3853247 | core_pubmed_pmc | Saturable human neopterin response to interferon-α assessed by a pharmacokinetic-pharmacodynamic model | Saturable human neopterin response to interferon-α assessed by a pharmacokinetic-pharmacodynamic model Abstract Background In this study, we developed a pharmacokinetic (PK)- pharmacodynamic (PD) model of a new sustained release formulation of interferon-α-2a (SR-IFN-α) using the blood concentration of IFN-α and neopte... |
PMC7891606 | core_pubmed_pmc | Effect of Opicapone Tablets on Levodopa and 3‐O‐Methyldopa Pharmacokinetics in Healthy Japanese Subjects: Phase 1 Study | Effect of Opicapone Tablets on Levodopa and 3‐O‐Methyldopa Pharmacokinetics in Healthy Japanese Subjects: Phase 1 Study Abstract Abstract This study evaluated the effect of a small‐tablet formulation of opicapone for use in clinical trials in Japan on the pharmacokinetics of levodopa ( l ‐dopa) and 3‐O‐methyldopa (3‐OM... |
PMC12566936 | core_pubmed_pmc | DST-3, a Novel Modified Cryptotanshinone, Protects Against Pulmonary Fibrosis via Inhibiting STAT3/Smad Signaling Pathway and Improves Bioavailability | DST-3, a Novel Modified Cryptotanshinone, Protects Against Pulmonary Fibrosis via Inhibiting STAT3/Smad Signaling Pathway and Improves Bioavailability Abstract Abstract Background/Objectives : Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by progressive loss of lung function and poor prognos... |
PMC10106804 | core_pubmed_pmc | Nanoparticle-Based Combination Therapy for Ovarian Cancer | Nanoparticle-Based Combination Therapy for Ovarian Cancer Abstract Abstract Ovarian cancer is one of the most common malignant tumors in gynecology with a high incidence. Combination therapy, eg, administration of paclitaxel followed by a platinum anticancer drug is recommended to treat ovarian cancer due to its advant... |
PMC6902850 | core_pubmed_pmc | Association Between Ambient Air Pollution and Elevated Risk of Tuberculosis Development | Association Between Ambient Air Pollution and Elevated Risk of Tuberculosis Development Abstract Background Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly u... |
PMC8621697 | core_pubmed_pmc | Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs | Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations & Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs Abstract Abstract A series of methyl β-D-galactopyranoside (MGP, 1 ) analogs were selectively acylated with cinnamoyl chloride in anhydrous N , N -dimet... |
PMC7012088 | core_pubmed_pmc | Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain | Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain Abstract ABSTRACT Introduction : Transporters comprising the blood-brain barrier complicate delivery of many therapeutics to the central nervous system. The present study ascertained whether the natural product botryllamide G is viable... |
PMC12863071 | core_pubmed_pmc | predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs | predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs Abstract Abstract We recently used drug-induced transcriptomic responses and whole-genome sequences in healthy human induced pluripotent stem cell (iPSC)-derived cardiomyocytes to identify cellular ... |
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