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PMC11469630 | core_pubmed_pmc | Subcutaneous Versus Intravenous Amivantamab, Both in Combination With Lazertinib, in Refractory Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer: Primary Results From the Phase III PALOMA-3 Study | Subcutaneous Versus Intravenous Amivantamab, Both in Combination With Lazertinib, in Refractory Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung Cancer: Primary Results From the Phase III PALOMA-3 Study Abstract Abstract PURPOSE Phase III studies of intravenous amivantamab demonstrated efficacy across epide... |
PMC9137891 | core_pubmed_pmc | Key Factors in Effective Patient-Tailored Dosing of Fluoroquinolones in Urological Infections: Interindividual Pharmacokinetic and Pharmacodynamic Variability | Key Factors in Effective Patient-Tailored Dosing of Fluoroquinolones in Urological Infections: Interindividual Pharmacokinetic and Pharmacodynamic Variability Abstract Abstract Fluoroquinolones (FQs) are a critical group of antimicrobials prescribed in urological infections as they have a broad antimicrobial spectrum o... |
PMC12151713 | core_pubmed_pmc | Beta 2 ‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration | Beta 2 ‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration Abstract Abstract Salbutamol is a common short‐acting beta 2 ‐adrenergic agonist used in treatment of asthma and exercise‐induced bronchoconstriction but also possesses anabolic... |
PMC12857586 | core_pubmed_pmc | The Present and Future of Pain Management in Patients With Chronic Kidney Disease: A Narrative Review | The Present and Future of Pain Management in Patients With Chronic Kidney Disease: A Narrative Review Abstract Chronic kidney disease (CKD) is an increasingly common ailment, greatly affecting the quality of life, morbidity, and mortality of the population. In addition, more than half of patients with CKD experience ch... |
PMC12093351 | core_pubmed_pmc | If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain–Barré syndrome | If it does not help, it might hurt: Pharmacodynamics of a second IVIg course in Guillain–Barré syndrome Abstract Abstract Objectives Intravenous immunoglobulin (IVIg) is an effective treatment for Guillain–Barré syndrome (GBS), but recovery varies between patients. This study aims to evaluate the pharmacokinetics (PK) ... |
PMC10069443 | core_pubmed_pmc | Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring | Precision sirolimus dosing in children: The potential for model-informed dosing and novel drug monitoring Abstract Abstract The mTOR inhibitor sirolimus is prescribed to treat children with varying diseases, ranging from vascular anomalies to sporadic lymphangioleiomyomatosis to transplantation (solid organ or hematopo... |
PMC10604101 | core_pubmed_pmc | Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice | Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice Abstract Low tumor delivery efficiency is a critical barrier in cancer nanomedicine. This study reports an updated version of “Nano-Tumor Database”, which increases the number of time-dependent concentration data sets for differ... |
PMC7205843 | core_pubmed_pmc | Phase I pharmacological study of continuous chronomodulated capecitabine treatment | Phase I pharmacological study of continuous chronomodulated capecitabine treatment Abstract Purpose Capecitabine is an oral pre-pro-drug of the anti-cancer drug 5-fluorouracil (5-FU). The biological activity of the 5-FU degrading enzyme, dihydropyrimidine dehydrogenase (DPD), and the target enzyme thymidylate synthase ... |
PMC4461087 | core_pubmed_pmc | Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy | Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy Abstract Regimen adherence, systemic toxicities, and limited drug penetrance to viral reservoirs are obstacles limiting the effectiveness of antiretroviral therapy (ART). Our lab... |
PMC12227211 | core_pubmed_pmc | Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial | Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial Abstract Background: Sugammadex is well tolerated and effective for reversing neuromuscular blockade (NMB) in adults and children as young as 2 yr old. There is little infor... |
PMC10505123 | core_pubmed_pmc | Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations | Assessment of Drug–Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations Abstract Abstract Introduction An unsafe injection practice is one of the major contributors to new hepa... |
PMC12916861 | core_pubmed_pmc | Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long‐Acting Injectables ‐ Where to Begin With Critical Bioavailability Attributes? | Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long‐Acting Injectables ‐ Where to Begin With Critical Bioavailability Attributes? Abstract ABSTRACT Long‐acting injectables (LAI) are of increasing interest as they facilitate improved medication adherence and exposure, with target plasma concentrati... |
PMC8047196 | core_pubmed_pmc | Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients | Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients Abstract Background : The goal of the study was to assess the relationship between single nucleotide variants (SNVs) in calcineurin inhibitor (CNI) pharmacokinetic a... |
PMC6315196 | core_pubmed_pmc | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong | The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong Abstract Abstract The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based... |
PMC5850836 | core_pubmed_pmc | The road from development to approval: evaluating the body of evidence to confirm biosimilarity | The road from development to approval: evaluating the body of evidence to confirm biosimilarity Abstract Abstract Biosimilars are products that contain a similar version of the active substance of an already authorized original biologic medicinal product (reference medicinal product). Their development requires special... |
PMC7125069 | core_pubmed_pmc | The impact of patient characteristics on enzalutamide pharmacokinetics and how this relates to treatment toxicity and efficacy in metastatic prostate cancer patients | The impact of patient characteristics on enzalutamide pharmacokinetics and how this relates to treatment toxicity and efficacy in metastatic prostate cancer patients Abstract Abstract Purpose The aim of the study is to investigate the influence of patient characteristics, age and body mass index (BMI), on pharmacokinet... |
PMC8170747 | core_pubmed_pmc | Development and Comparison of Intramuscularly Injected Long-acting Testosterone Undecanoate Nano-/Microcrystal Suspensions with Three Different Particle Size | Development and Comparison of Intramuscularly Injected Long-acting Testosterone Undecanoate Nano-/Microcrystal Suspensions with Three Different Particle Size Abstract The aim of this study was to develop and compare the pharmacokinetic property of testosterone undecanoate (TU) nano-/microcrystal suspension with three d... |
PMC8165402 | core_pubmed_pmc | The EMA assessment of avapritinib in the treatment of gastrointestinal stromal tumours harbouring the PDGFRA D842V mutation | The EMA assessment of avapritinib in the treatment of gastrointestinal stromal tumours harbouring the PDGFRA D842V mutation Abstract Avapritinib is a protein kinase inhibitor designed to selectively inhibit oncogenic KIT and platelet-derived growth factor receptor alpha (PDGFRA) mutants by targeting the active conforma... |
PMC12716709 | core_pubmed_pmc | Dose-finding for dobutamine during transitional circulation in the very preterm infant: The study protocol | Dose-finding for dobutamine during transitional circulation in the very preterm infant: The study protocol Abstract Abstract Background Hemodynamic insufficiency occurs when tissue oxygen delivery fails to meet demand. Preterm infants are vulnerable to early circulatory failure after birth, impacting mortality and morb... |
PMC11210524 | core_pubmed_pmc | Revolutionizing migraine management: advances and challenges in CGRP-targeted therapies and their clinical implications | Revolutionizing migraine management: advances and challenges in CGRP-targeted therapies and their clinical implications Abstract Abstract Migraine, a prevalent neurological disorder, affects approximately 14.1% of the global population and disproportionately impacts females. This debilitating condition significantly co... |
PMC5008110 | core_pubmed_pmc | Population pharmacokinetics of tenofovir and tenofovir‐diphosphate in healthy women | Population pharmacokinetics of tenofovir and tenofovir‐diphosphate in healthy women Abstract Abstract The objective of this analysis was to develop and qualify a population pharmacokinetic model describing plasma tenofovir (TFV) concentrations and tenofovir‐diphosphate (TFV‐DP) concentrations in peripheral blood mononu... |
PMC3573828 | core_pubmed_pmc | Oral treatment with etoposide in small cell lung cancer – dilemmas and solutions | Oral treatment with etoposide in small cell lung cancer – dilemmas and solutions Abstract Background Etoposide is a chemotherapeutic agent, widely used for the treatment of various malignancies, including small cell lung cancer (SCLC), an aggressive disease with poor prognosis. Oral etoposide administration exhibits ad... |
PMC11242736 | core_pubmed_pmc | Protective Effect of Arzanol against H 2 O 2 -Induced Oxidative Stress Damage in Differentiated and Undifferentiated SH-SY5Y Cells | Protective Effect of Arzanol against H 2 O 2 -Induced Oxidative Stress Damage in Differentiated and Undifferentiated SH-SY5Y Cells Abstract Abstract Oxidative stress can damage neuronal cells, greatly contributing to neurodegenerative diseases (NDs). In this study, the protective activity of arzanol, a natural prenylat... |
PMC6154683 | core_pubmed_pmc | High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates | High-Throughput Determination of Sodium Danshensu in Beagle Dogs by the LCMS/MS Method, Employing Liquid-Liquid Extraction Based on 96-Well Format Plates Abstract Sodium Danshensu (sodium d -(+)-β-(3,4-dihydroxyphenyl) lactate), one of the water-soluble ingredients in Salvia miltiorrhiza , exhibits potent relaxation of... |
PMC9006903 | core_pubmed_pmc | Stimulus-responsive self-assembled prodrugs in cancer therapy | Stimulus-responsive self-assembled prodrugs in cancer therapy Abstract Abstract Small-molecule prodrugs have become the main toolbox to improve the unfavorable physicochemical properties of potential therapeutic compounds in contemporary anti-cancer drug development. Many approved small-molecule prodrugs, however, stil... |
PMC12189272 | core_pubmed_pmc | Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States | Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States Abstract The resurgence of phage therapy in Western societies has been in direct response to recent increases in antimicrobial resistance (AMR) that have ravaged many societies. While phage therapy as a concept has been ... |
PMC12649288 | core_pubmed_pmc | Population Pharmacokinetic and Exposure‐Efficacy Analyses of Valbenazine in Patients with Huntington's Disease: Supporting Dose Selection for Chorea Management | Population Pharmacokinetic and Exposure‐Efficacy Analyses of Valbenazine in Patients with Huntington's Disease: Supporting Dose Selection for Chorea Management Abstract Abstract Valbenazine improved chorea in individuals with Huntington's disease compared to placebo in a phase 3, placebo‐controlled study (KINECT‐HD). P... |
PMC4768075 | core_pubmed_pmc | Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish | Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish Abstract Abstract The Adverse Outcome Pathway (AOP) framework represents a valuable conceptual tool to systematically integrate existing toxicological knowledge from a mechanistic perspective to facilitate predictions of ... |
PMC9597002 | core_pubmed_pmc | The Combination of Individual Herb of Mi-Jian-Chang-Pu Formula Exerts a Synergistic Effect in the Treatment of Ischemic Stroke in Rats | The Combination of Individual Herb of Mi-Jian-Chang-Pu Formula Exerts a Synergistic Effect in the Treatment of Ischemic Stroke in Rats Abstract Mi-Jian-Chang-Pu formula (MJCPF), composed of Crocus sativus L . and Acorus tatarinowii Schott, is a well-known TCM for treatment of hemiplegia, facial paralysis as well as lan... |
PMC9523343 | core_pubmed_pmc | Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens | Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens Abstract Abstract Background Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in la... |
PMC5836964 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis | Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis Abstract Abstract Etrolizumab, a humanized monoclonal antibody, specifically binds to the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. Pharmacokinetic (PK) and pharmaco... |
PMC4916199 | core_pubmed_pmc | Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen | Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen Abstract Introduction Acetaminophen (paracetamol) is mainly metabolized via glucuronidation and sulphation, while the minor pathway through cytochrome P450 (CYP) 2E1 is held responsible for hepatotoxicity. In obese patients, CYP2E1 act... |
PMC7987154 | core_pubmed_pmc | Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study | Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study Abstract Abstract Interleukin-7 (IL-7) signaling modulates T cell activity and is implicated in numerous autoimmune diseases. An anti-IL-7 receptor mo... |
PMC5241936 | core_pubmed_pmc | Is there a justification for classifying GLP-1 receptor agonists as basal and prandial? | Is there a justification for classifying GLP-1 receptor agonists as basal and prandial? Abstract Several GLP-1 receptor agonists are currently available for treatment of type 2 diabetic patients. Based on their pharmacokinetic/pharmacodynamic profile, these drugs are classified as short-acting GLP-1 receptor agonists (... |
PMC12642347 | core_pubmed_pmc | Asundexian: a systematic review of safety, efficacy, and pharmacological insights in thrombosis | Asundexian: a systematic review of safety, efficacy, and pharmacological insights in thrombosis Abstract Abstract Background Asundexian, a novel oral Factor XIa (FXIa) inhibitor, targets the intrinsic coagulation pathway to prevent thrombosis while potentially reducing bleeding risk compared to direct oral anticoagulan... |
PMC10874917 | core_pubmed_pmc | Prolonged versus intermittent β-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials | Prolonged versus intermittent β-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials Abstract Abstract Background The two latest studies on prolonged versus intermittent use of β-lactam antibiotics in patients with sepsis did not reach consistent conclusions, further contribu... |
PMC8121850 | core_pubmed_pmc | In-vitro and in-vivo metabolism of different aspirin formulations studied by a validated liquid chromatography tandem mass spectrometry method | In-vitro and in-vivo metabolism of different aspirin formulations studied by a validated liquid chromatography tandem mass spectrometry method Abstract Abstract Low-dose aspirin (ASA) is used to prevent cardiovascular events. The most commonly used formulation is enteric-coated ASA (EC-ASA) that may be absorbed more sl... |
PMC10539217 | core_pubmed_pmc | Pharmacokinetic relevance of glomerular hyperfiltration for drug dosing | Pharmacokinetic relevance of glomerular hyperfiltration for drug dosing Abstract ABSTRACT In chronic kidney disease (CKD) patients, hypofiltration may lead to the accumulation of drugs that are cleared mainly by the kidney and, vice versa, hyperfiltration may cause augmented renal excretion of the same drugs. In this r... |
PMC7438808 | core_pubmed_pmc | Tumor Growth Dynamic Modeling in Oncology Drug Development and Regulatory Approval: Past, Present, and Future Opportunities | Tumor Growth Dynamic Modeling in Oncology Drug Development and Regulatory Approval: Past, Present, and Future Opportunities Abstract Model‐informed drug development (MIDD) approaches have rapidly advanced in drug development in recent years. Additionally, the Prescription Drug User Fee Act (PDUFA) VI has specific commi... |
PMC8997953 | core_pubmed_pmc | Polyphenols and Their Metabolites in Renal Diseases: An Overview | Polyphenols and Their Metabolites in Renal Diseases: An Overview Abstract Abstract Kidney diseases constitute a worldwide public health problem, contributing to morbidity and mortality. The present study aimed to provide an overview of the published data regarding the potential beneficial effects of polyphenols on majo... |
PMC9870224 | core_pubmed_pmc | Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma | Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric BRAF V600–Mutant Low-Grade Glioma Abstract PURPOSE BRAF V600 mutations occur in many childhood cancers, including approximately 20% of low-grade gliomas (LGGs). Here, we describe a phase I/II study establishing pediatric dosing... |
PMC11647907 | core_pubmed_pmc | Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity | Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity Abstract Human sapiens caseinolytic protease P (ClpP) is essential for maintaining mitochondrial proteome homeostasis, and its activation is increasingly recognized as a promising cancer ... |
PMC10579980 | core_pubmed_pmc | SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties | SRF617 Is a Potent Inhibitor of CD39 with Immunomodulatory and Antitumor Properties Abstract Abstract CD39 (ENTPD1) is a key enzyme responsible for degradation of extracellular ATP and is upregulated in the tumor microenvironment (TME). Extracellular ATP accumulates in the TME from tissue damage and immunogenic cell de... |
PMC10915730 | core_pubmed_pmc | The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses | The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses Abstract Abstract Mitiperstat is a myeloperoxidase inhibitor in clinical development for treatment of patients with heart failure and preserved or mildly reduced ejection fraction, non‐alcoholic steatohepa... |
PMC7170455 | core_pubmed_pmc | Insulin/carbohydrates ratio during the first 6‐month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study | Insulin/carbohydrates ratio during the first 6‐month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study Abstract Abstract Background No data exist about the changes induced by the transition from first‐generation lo... |
PMC6832515 | core_pubmed_pmc | A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery | A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery Abstract Abstract Dexmedetomidine is a selective alpha-2 adrenergic agonist with concurrent sedative and analgesic effects, and it is being increasingly used in pediatric anesthesia and intensive ca... |
PMC9243584 | core_pubmed_pmc | Population Pharmacokinetics of Colistin Sulfate in Critically Ill Patients: Exposure and Clinical Efficacy | Population Pharmacokinetics of Colistin Sulfate in Critically Ill Patients: Exposure and Clinical Efficacy Abstract Abstract Background: Presently, colistin is commercially available in two different forms, namely, colistin sulfate and its sulphomethylated derivative, colistimethate sodium (CMS). However, in the curren... |
PMC9544110 | core_pubmed_pmc | Pharmacokinetics of maropitant citrate in Rhode Island Red chickens ( Gallus gallus domesticus ) following subcutaneous administration | Pharmacokinetics of maropitant citrate in Rhode Island Red chickens ( Gallus gallus domesticus ) following subcutaneous administration Abstract Abstract Maropitant citrate is a synthetic neurokinin‐1 receptor antagonist and substance P inhibitor used for control of emesis in dogs in cats. Maropitant citrate is used emp... |
PMC8611774 | core_pubmed_pmc | Defining and unpacking the core concepts of pharmacology education | Defining and unpacking the core concepts of pharmacology education Abstract Abstract Pharmacology education currently lacks a research‐based consensus on which core concepts all graduates should know and understand, as well as a valid and reliable means to assess core conceptual learning. The Core Concepts in Pharmacol... |
PMC12944037 | core_pubmed_pmc | Molecularly Tailored Artesunate Nanomedicine with Well-Balanced Nanoassembly and Anticancer Performance | Molecularly Tailored Artesunate Nanomedicine with Well-Balanced Nanoassembly and Anticancer Performance Abstract Background : Artesunate (ART), a natural product derivative of artemisinin, exhibits striking antitumor activity. However, the clinical translation of ART is limited by rapid clearance, poor tumor selectivit... |
PMC4037836 | core_pubmed_pmc | Phase I study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies | Phase I study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies Abstract Abstract Background: We assessed the maximum tolerated regimen (MTR) and dose-limiting toxicities of pazopanib and lapatinib in combination with weekly paclitaxel, and the effect of pazopanib and lapat... |
PMC11662097 | core_pubmed_pmc | RETRACTED ARTICLE: Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor | RETRACTED ARTICLE: Identifying therapeutic target for prostate cancer: exploring Diosmetin as a CYP inhibitor Abstract Abstract Prostate cancer is a prevalent and highly heterogeneous malignancy that affects men globally. Despite the availability of various treatment targets, Cytochrome P450 (CYP) enzymes have gained s... |
PMC3489518 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults | Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults Abstract Background Severe malaria is a medical emergency with high mortality. Prompt achievement of therapeutic concentrations of highly effective anti-malarial drugs reduces the risk of death. The aim of ... |
PMC5412890 | core_pubmed_pmc | A phase 1/2 trial of ublituximab, a novel anti‐ CD 20 monoclonal antibody, in patients with B‐cell non‐Hodgkin lymphoma or chronic lymphocytic leukaemia previously exposed to rituximab | A phase 1/2 trial of ublituximab, a novel anti‐ CD 20 monoclonal antibody, in patients with B‐cell non‐Hodgkin lymphoma or chronic lymphocytic leukaemia previously exposed to rituximab Abstract Summary This phase 1/2 study evaluated the safety, pharmacokinetic behavior and anti‐tumour activity of ublituximab, a unique ... |
PMC4857081 | core_pubmed_pmc | PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers | PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers Abstract Abstract Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-... |
PMC4158154 | core_pubmed_pmc | Hypoxia in Head and Neck Cancer in Theory and Practice: A PET-Based Imaging Approach | Hypoxia in Head and Neck Cancer in Theory and Practice: A PET-Based Imaging Approach Abstract Abstract Hypoxia plays an important role in tumour recurrence among head and neck cancer patients. The identification and quantification of hypoxic regions are therefore an essential aspect of disease management. Several predi... |
PMC12185669 | core_pubmed_pmc | Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling | Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling Abstract Abstract The emergence of novel synthetic opioids (NSOs) poses significant challenges to public health, toxicologists, and law enforcement. Since the comprehensive scheduling of fentanyl analog... |
PMC6356991 | core_pubmed_pmc | Systematic Review and Bayesian Meta-analysis of the Dose-response Relationship between Folic Acid Intake and Changes in Blood Folate Concentrations | Systematic Review and Bayesian Meta-analysis of the Dose-response Relationship between Folic Acid Intake and Changes in Blood Folate Concentrations Abstract The threshold for population-level optimal red blood cell (RBC) folate concentration among women of reproductive age for the prevention of neural tube defects has ... |
PMC8915582 | core_pubmed_pmc | Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats | Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats Abstract Filgotinib is a selective JAK1 (Janus kinase) inhibitor, showed efficacy in patients suffering from moderate-to-severe rheumatoid arthritis. In this paper, we present the data on the... |
PMC10984953 | core_pubmed_pmc | Therapeutic drug monitoring of liposomal amphotericin B in children. Are we there yet? A systematic review | Therapeutic drug monitoring of liposomal amphotericin B in children. Are we there yet? A systematic review Abstract Abstract Introduction Therapeutic drug monitoring (TDM) is a tool that supports personalized dosing, but its role for liposomal amphotericin B (L-amb) is unclear. This systematic review assessed the evide... |
PMC10321640 | core_pubmed_pmc | The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody | The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody Abstract Abstract We have previously demonstrated that KS-133 is a specific and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2)... |
PMC7601871 | core_pubmed_pmc | Some Suggestions from PK/PD Principles to Contain Resistance in the Clinical Setting—Focus on ICU Patients and Gram-Negative Strains | Some Suggestions from PK/PD Principles to Contain Resistance in the Clinical Setting—Focus on ICU Patients and Gram-Negative Strains Abstract Abstract The containment of the phenomenon of resistance towards antimicrobials is a priority, especially in preserving molecules acting against Gram-negative pathogens, which re... |
PMC8858085 | core_pubmed_pmc | Pharmacokinetic and subjective assessment of prototype JUUL2 electronic nicotine delivery system in two nicotine concentrations, JUUL system, IQOS, and combustible cigarette | Pharmacokinetic and subjective assessment of prototype JUUL2 electronic nicotine delivery system in two nicotine concentrations, JUUL system, IQOS, and combustible cigarette Abstract Rationale Electronic nicotine delivery systems and heated tobacco products are noncombustible alternatives for adult smokers. Evidence su... |
PMC11515340 | core_pubmed_pmc | Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumonia e: pharmacokinetics-pharmacodynamics combined with transcriptomic approach | Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumonia e: pharmacokinetics-pharmacodynamics combined with transcriptomic approach Abstract Abstract Objectives The aim of this study was to identify the synergistic effect and mechanisms of fosfomycin (FM) combined with colistin (COL) aga... |
PMC10754550 | core_pubmed_pmc | Patient with congenital factor VII deficiency undergoing brain tumor neurosurgery successfully treated with recombinant factor VIIa and fresh frozen plasma: A case report and literature review | Patient with congenital factor VII deficiency undergoing brain tumor neurosurgery successfully treated with recombinant factor VIIa and fresh frozen plasma: A case report and literature review Abstract Abstract Rationale: Congenital factor VII deficiency is the most common among rare bleeding disorders, characterized b... |
PMC4554462 | core_pubmed_pmc | New developments in atherosclerosis: clinical potential of PCSK9 inhibition | New developments in atherosclerosis: clinical potential of PCSK9 inhibition Abstract Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is a secreted 692-amino acid protein that binds surface low-density lipoprotein (LDL) receptor (LDLR) and targets it toward lysosomal degradation. As a consequence, the number of L... |
PMC7925021 | core_pubmed_pmc | UPLC-MS/MS for the Herb-Drug Interactions of Xiao-Ai-Ping Injection on Enasidenib in Rats Based on Pharmacokinetics | UPLC-MS/MS for the Herb-Drug Interactions of Xiao-Ai-Ping Injection on Enasidenib in Rats Based on Pharmacokinetics Abstract Objective To develop and validate a sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of enasidenib in rat plasma and t... |
PMC6819656 | core_pubmed_pmc | Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections In Situ | Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections In Situ Abstract Molecular imaging is an emerging technology that enables the noninvasive visualization, characterization, and quantification of molecular events within living subjects. Positron emission tomography (PET) is a clinically available m... |
PMC11531826 | core_pubmed_pmc | Clinically important interactions of macrolides and tetracyclines with dietary interventions—a systematic review with meta-analyses | Clinically important interactions of macrolides and tetracyclines with dietary interventions—a systematic review with meta-analyses Abstract Abstract Background Effective management of drug–food interactions is crucial for enhancing antibiotics’ efficacy/safety. Adhering to PRISMA guidelines, we conducted a systematic ... |
PMC11891238 | core_pubmed_pmc | Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study | Changes in the blood cyclosporine level after switching from voriconazole to isavuconazole in a patient with aplastic anemia: insights from physiologically based pharmacokinetic model simulation and the Adverse Event Reporting System database study Abstract Introduction Isavuconazole, a broad-spectrum triazole approved... |
PMC10056013 | core_pubmed_pmc | Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review | Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review Abstract Abstract Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of drug delivery methods. These model... |
PMC3675041 | core_pubmed_pmc | A Biomathematical Model of Human Erythropoiesis under Erythropoietin and Chemotherapy Administration | A Biomathematical Model of Human Erythropoiesis under Erythropoietin and Chemotherapy Administration Abstract Abstract Anaemia is a common haematologic side effect of dose-dense multi-cycle cytotoxic polychemotherapy requiring erythrocyte transfusions or erythropoietin (EPO) administration. To simulate the effectivenes... |
PMC3465130 | core_pubmed_pmc | Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer | Preparation and characterization of albumin nanoparticles encapsulating curcumin intended for the treatment of breast cancer Abstract Abstract Introduction: For the real-time clinical utilization of curcumin (an ayurvedic natural product) to treat breast cancer, its dissolution, rate limited solubility, poor tissue abs... |
PMC12922225 | core_pubmed_pmc | Continuous versus intermittent vancomycin infusions in critically ill children with gram-positive bacterial infections: a randomized controlled trial | Continuous versus intermittent vancomycin infusions in critically ill children with gram-positive bacterial infections: a randomized controlled trial Abstract Abstract Objective This randomized controlled trial (RCT) compares continuous intravenous infusion (CIV) and intermittent infusion of vancomycin (IIV) regimens (... |
PMC9079007 | core_pubmed_pmc | Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice | Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice Abstract Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show that therapeutic level... |
PMC8423982 | core_pubmed_pmc | Reldesemtiv in Patients with Spinal Muscular Atrophy: a Phase 2 Hypothesis-Generating Study | Reldesemtiv in Patients with Spinal Muscular Atrophy: a Phase 2 Hypothesis-Generating Study Abstract Abstract This phase 2, double-blind, placebo-controlled, hypothesis-generating study evaluated the effects of oral reldesemtiv , a fast skeletal muscle troponin activator, in patients with spinal muscular atrophy (SMA).... |
PMC12649291 | core_pubmed_pmc | Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma | Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma Abstract Abstract Valemetostat is a dual inhibitor of EZH2/1 approved in Japan for the treatment of relapsed/refractory (R/R) adult T–cell lymphoma/leukemia (... |
PMC11881160 | core_pubmed_pmc | Evaluation of Luteolin Nanosuspensions on Pharmacokinetics of Atorvastatin: Drug-Drug Interactions Using Rat Models | Evaluation of Luteolin Nanosuspensions on Pharmacokinetics of Atorvastatin: Drug-Drug Interactions Using Rat Models Abstract Purpose The co-administration of luteolin (LUT) and atorvastatin (ATV) may drive synergetic effects on against atherosclerotic cardiovascular disease (ASCVD). This study aims to explore the pharm... |
PMC9544596 | core_pubmed_pmc | Comparison of Race‐Based and Non–Race‐Based Equations for Kidney Function Estimation in Critically Ill Thai Patients for Vancomycin Dosing | Comparison of Race‐Based and Non–Race‐Based Equations for Kidney Function Estimation in Critically Ill Thai Patients for Vancomycin Dosing Abstract Abstract Empiric antibiotic dosing frequently relies on an estimate of kidney function based on age, serum creatinine, sex, and race (on occasion). New non–race‐based estim... |
PMC12610815 | core_pubmed_pmc | Personalizing IL-23 Inhibitor Therapy in IBD: Current Evidence and Future Directions in Therapeutic Drug Monitoring and Dose Optimization | Personalizing IL-23 Inhibitor Therapy in IBD: Current Evidence and Future Directions in Therapeutic Drug Monitoring and Dose Optimization Abstract Interleukin-23 (IL-23) inhibitors have rapidly become an essential component of the therapeutic armamentarium for inflammatory bowel disease (IBD). Risankizumab, mirikizumab... |
PMC8325523 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic investigation of raltegravir with or without lamivudine in the context of HIV-1 pre-exposure prophylaxis (PrEP) | Pharmacokinetic/pharmacodynamic investigation of raltegravir with or without lamivudine in the context of HIV-1 pre-exposure prophylaxis (PrEP) Abstract Abstract Background To characterize their potential use in pre-exposure prophylaxis (PrEP) we compared the pharmacokinetics of raltegravir and lamivudine in genital ti... |
PMC7930639 | core_pubmed_pmc | Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database | Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database Abstract Abstract Alismatis Rhizoma (AR) is widely used in Chinese medicine, and its major bioactive components, triterpenes, reportedly possess various pharmacological activities. Therefore... |
PMC7324464 | core_pubmed_pmc | Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader | Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader Abstract Purpose Preclinical in vivo nuclear imaging of mice offers an enabling perspective to evaluate drug efficacy at optimal dose a... |
PMC10272305 | core_pubmed_pmc | PK/PD modeling to characterize placebo and treatment effect of omalizumab for chronic spontaneous urticaria | PK/PD modeling to characterize placebo and treatment effect of omalizumab for chronic spontaneous urticaria Abstract Abstract The pharmacokinetic (PK) characteristics of omalizumab and its pharmacodynamic (PD) effect in patients has yet to be fully characterized in chronic spontaneous urticaria, which could elucidate i... |
PMC6691885 | core_pubmed_pmc | Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats | Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats Abstract Abstract Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats. Materi... |
PMC7759489 | core_pubmed_pmc | Population Pharmacodynamic Modeling Using the Sigmoid E max Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study | Population Pharmacodynamic Modeling Using the Sigmoid E max Model: Influence of Inter-individual Variability on the Steepness of the Concentration–Effect Relationship. a Simulation Study Abstract The relationship between the concentration of a drug and its pharmacological effect is often described by empirical mathemat... |
PMC8132247 | core_pubmed_pmc | Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections | Pharmacokinetic-based failure of a detergent virucidal for SARS-COV-2 nasal infections Abstract The nose is the portal for SARS-CoV-2 infection, suggesting the nose as a target for topical antiviral therapies. Because detergents are virucidal, Johnson and Johnson’s Baby Shampoo (J&J) was tested as a topical virucidal a... |
PMC7379096 | core_pubmed_pmc | In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules | In Situ Forming Injectable Thermoresponsive Hydrogels for Controlled Delivery of Biomacromolecules Abstract Due to their relatively large molecular sizes and delicate nature, biologic drugs such as peptides, proteins, and antibodies often require high and repeated dosing, which can cause undesired side effects and phys... |
PMC7484986 | core_pubmed_pmc | Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology | Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology Abstract Bispecific antibodies (bsAbs) have become an integral component of the therapeutic research strategy to treat cancer. In addition to clinically validated immune cell re‐targeting, bsAbs are ... |
PMC9138153 | core_pubmed_pmc | Comparison of Piperacillin and Tazobactam Pharmacokinetics in Critically Ill Patients with Trauma or with Burn | Comparison of Piperacillin and Tazobactam Pharmacokinetics in Critically Ill Patients with Trauma or with Burn Abstract Abstract Critical illness caused by burn and sepsis is associated with pathophysiologic changes that may result in the alteration of pharmacokinetics (PK) of antibiotics. However, it is unclear if one... |
PMC6748587 | core_pubmed_pmc | Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 | Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4 Abstract ABSTRACT Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream... |
PMC4992966 | core_pubmed_pmc | Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy | Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy Abstract ABSTRACT Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a stan... |
PMC12282105 | core_pubmed_pmc | In vitro and in silico studies of the SARS-CoV-2 main protease inhibition and antioxidant activities of isolated compounds from Marrubium alysson L. † | In vitro and in silico studies of the SARS-CoV-2 main protease inhibition and antioxidant activities of isolated compounds from Marrubium alysson L. † Abstract Abstract A phytochemical investigation of the aerial parts of Marrubium alysson L. yielded 10 compounds: β-sitosterol (1), glycerol monopalmitate (2), β-sitoste... |
PMC6921430 | core_pubmed_pmc | Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients | Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients Abstract Background Tamoxifen is considered a prodrug of its active metabolite endoxifen, which is dependent on the CYP2D6 and CYP3A enzymes. Tamoxifen pharmacokinetic variability influences endoxif... |
PMC12681151 | core_pubmed_pmc | Design, optimization of Niosomal gel capability for solubility and bioavailability enhancement of Kynurenic acid after intranasal administration: In Vitro and In Vivo Evaluation | Design, optimization of Niosomal gel capability for solubility and bioavailability enhancement of Kynurenic acid after intranasal administration: In Vitro and In Vivo Evaluation Abstract Background Kynurenic acid (KNA) could be useful in treating neurological diseases; nevertheless, the fact that it couldn’t penetrate ... |
PMC9083226 | core_pubmed_pmc | Hydromorphone Prescription for Pain in Children—What Place in Clinical Practice? | Hydromorphone Prescription for Pain in Children—What Place in Clinical Practice? Abstract While morphine is the gold standard treatment for severe nociceptive pain in children, hydromorphone is increasingly prescribed in this population. This review aims to assess available knowledge about hydromorphone and explore the... |
PMC11251465 | core_pubmed_pmc | How many patients do you need? Investigating trial designs for anti‐seizure treatment in acute brain injury patients | How many patients do you need? Investigating trial designs for anti‐seizure treatment in acute brain injury patients Abstract Abstract Background/objectives Epileptiform activity (EA), including seizures and periodic patterns, worsens outcomes in patients with acute brain injuries (e.g., aneurysmal subarachnoid hemorrh... |
PMC3995251 | core_pubmed_pmc | Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population | Mapping of hepatic expression quantitative trait loci (eQTLs) in a Han Chinese population Abstract Abstract Background Elucidating the genetic basis underlying hepatic gene expression variability is of importance to understand the aetiology of the disease and variation in drug metabolism. To date, no genome-wide expres... |
PMC6682894 | core_pubmed_pmc | Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies | Dietary Anthocyanins and Stroke: A Review of Pharmacokinetic and Pharmacodynamic Studies Abstract Cerebrovascular accidents are currently the second major cause of death and the third leading cause of disability in the world, according to the World Health Organization (WHO), which has provided protocols for stroke prev... |
PMC3661232 | core_pubmed_pmc | Duloxetine: A Review of Its Safety and Efficacy in the Management of Fibromyalgia Syndrome | Duloxetine: A Review of Its Safety and Efficacy in the Management of Fibromyalgia Syndrome Abstract Abstract Fibromyalgia (FM) is a chronic disorder characterized by widespread pain and other associated symptoms including fatigue, insomnia, cognitive/memory problems, and even psychological distress. Duloxetine is one o... |
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