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PMC6288471 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration | Pharmacokinetics and Pharmacodynamics of an Oral Formulation of Apixaban in Horses After Oral and Intravenous Administration Abstract Abstract Horses with inflammatory and infectious disorders are often treated with injectable heparin anticoagulants to prevent thrombotic complications. In humans, a new class of direct ... |
PMC10491557 | core_pubmed_pmc | Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study | Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study Abstract Background Cardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients are the most affected by cardiovascular diseases, and b... |
PMC9155615 | core_pubmed_pmc | Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization–Recommended Weight Band Doses and Formulations | Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization–Recommended Weight Band Doses and Formulations Abstract Abstract Background Dispersible pediatric fixed-dose combination (FDC) tablets delivering higher doses of first-line antituberculosis drugs in World Health Organiza... |
PMC12704320 | core_pubmed_pmc | Non-linear pharmacokinetics of penciclovir in healthy cats after single and multiple oral administration of famciclovir | Non-linear pharmacokinetics of penciclovir in healthy cats after single and multiple oral administration of famciclovir Abstract Introduction Feline Infectious Rhinobronchitis (FVR) is a common and serious infectious upper respiratory disease. Famciclovir, an antiviral prodrug initially developed for human herpesviruse... |
PMC5391214 | core_pubmed_pmc | Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects | Association of genetic variations with pharmacokinetics and lipid-lowering response to atorvastatin in healthy Korean subjects Abstract Background Statins are effective agents in the primary and secondary prevention of cardiovascular disease, but treatment response to statins varies among individuals. We analyzed multi... |
PMC8347666 | core_pubmed_pmc | Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats | Assessment of glibenclamide pharmacokinetics in poloxamer 407-induced hyperlipidemic rats Abstract The aim of the present research was to describe the consequences of hyperlipidemia (HL) on the pharmacokinetics of glibenclamide (Gb) in poloxamer 407-induced hyperlipidemic rats. Rats were given intraperitoneal dose of p... |
PMC7322745 | core_pubmed_pmc | Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng | Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng Abstract Abstract Background It is well recognized that gut microbiota is involved in the biotransformation of ginsenosides by converting the polar ginsenos... |
PMC11168663 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of intravenously and subcutaneously administered pantoprazole in sheep ( Ovis aries ) | Pharmacokinetics and pharmacodynamics of intravenously and subcutaneously administered pantoprazole in sheep ( Ovis aries ) Abstract Abstract Abomasal ulcers are recognized in sheep of all ages, but research regarding therapeutic interventions is limited. Proton Pump Inhibitors (PPIs) such as pantoprazole, are clinical... |
PMC10960884 | core_pubmed_pmc | Exposure–Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome | Exposure–Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome Abstract Abstract Introduction Trofinetide was recently approved for the treatment of Rett syndrome (RTT) on the basis of the efficacy and safety findings of the phase 3 LAVENDER study, which used a body weight-based dos... |
PMC4858693 | core_pubmed_pmc | Triple combination MPT vaginal microbicide using curcumin and efavirenz loaded lactoferrin nanoparticles | Triple combination MPT vaginal microbicide using curcumin and efavirenz loaded lactoferrin nanoparticles Abstract We report that a combination of anti-HIV-1 drug efavirenz (EFV), anti-microbial-spermicidal curcumin (Cur) and lactoferrin nanoparticles (ECNPs) act as MPT formulation. These nanoparticles are of well dispe... |
PMC7899551 | core_pubmed_pmc | Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors | Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Abstract Abstract Background: Differential responses to tamoxifen may be due to inter-patient variability in tamoxifen metabolism into pharmacologically active Z-endoxifen. Z-endoxifen administration ... |
PMC11545717 | core_pubmed_pmc | Determining the Pharmacokinetic Properties of Two Different Doses of Meloxicam in Barred Owls ( Strix varia ) | Determining the Pharmacokinetic Properties of Two Different Doses of Meloxicam in Barred Owls ( Strix varia ) Abstract Simple Summary Wildlife are negatively affected by human activities, and these encounters often lead to traumatic injuries requiring treatment. Unfortunately, our understanding of analgesics for injure... |
PMC9188223 | core_pubmed_pmc | Fluazuron orally administered to guinea pigs: pharmacokinetic and efficacy against Amblyomma sculptum | Fluazuron orally administered to guinea pigs: pharmacokinetic and efficacy against Amblyomma sculptum Abstract Background Brazilian spotted fever (BSF), the most lethal tick-borne disease in the Western Hemisphere, is caused by the bacterium Rickettsia rickettsii and transmitted by the bite of Amblyomma sculptum . Capy... |
PMC12332861 | core_pubmed_pmc | Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction | Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction Abstract Highlights • JK07 is a complex biologic consisting of the active domain of a fully human recombinant neuregulin-1 fused with an ErbB3 antagonist antibody, designed to selectively stimulate ErbB4. • Fourt... |
PMC12185637 | core_pubmed_pmc | Clinical Pharmacology of Loop Diuretics in Critical Care | Clinical Pharmacology of Loop Diuretics in Critical Care Abstract Abstract Loop diuretics are a cornerstone in the management of fluid overload in critically ill patients; however, their use is often complicated by variable pharmacokinetics and the phenomenon of diuretic resistance. This narrative review comprehensivel... |
PMC5340827 | core_pubmed_pmc | Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn 2+ -Suspension After Single Subcutaneous Injection in Female Rats | Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn 2+ -Suspension After Single Subcutaneous Injection in Female Rats Abstract Background and Objectives Although many synthetic gonadoliberin analogs have been developed, only a few of them, including buserelin, were introduced into cl... |
PMC12313450 | core_pubmed_pmc | Evaluation of amoxicillin and benzylpenicillin therapy in early-onset neonatal sepsis: a pharmacometric external validation and simulation study | Evaluation of amoxicillin and benzylpenicillin therapy in early-onset neonatal sepsis: a pharmacometric external validation and simulation study Abstract Abstract Background and objectives Early-onset sepsis (EOS) poses a significant morbidity and mortality risk in neonates, for which early diagnosis and adequate antib... |
PMC11570885 | core_pubmed_pmc | Preclinical characterization of MTX-101: a novel bispecific CD8 Treg modulator that restores CD8 Treg functions to suppress pathogenic T cells in autoimmune diseases | Preclinical characterization of MTX-101: a novel bispecific CD8 Treg modulator that restores CD8 Treg functions to suppress pathogenic T cells in autoimmune diseases Abstract Introduction Regulatory CD8 T cells (CD8 Treg) are responsible for the selective killing of self-reactive and pathogenic CD4 T cells. In autoimmu... |
PMC7398703 | core_pubmed_pmc | Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro | Antipsychotics drug aripiprazole as a lead against breast cancer cell line (MCF-7) in vitro Abstract Breast cancer is the second leading cause of death among women globally. The existing treatment options for breast cancer are largely associated with severe toxicities, and lower efficacies. Therefore, there is an urgen... |
PMC6933454 | core_pubmed_pmc | Sotatercept Safety and Effects on Hemoglobin, Bone, and Vascular Calcification | Sotatercept Safety and Effects on Hemoglobin, Bone, and Vascular Calcification Abstract Abstract Introduction Patients with end-stage kidney disease (ESKD) exhibit anemia, chronic kidney disease‒mineral bone disorder (CKD–MBD), and cardiovascular disease. The REN-001 and REN-002 phase II, multicenter, randomized studie... |
PMC10121353 | core_pubmed_pmc | Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis | Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis Abstract Abstract Objective To elucidate the mechanism of Spatholobi Caulis (SC) in treating osteoporosis (OP) integrated zebrafish model and bioinformatics. Methods Skeleton staining coupled with image quantific... |
PMC5760785 | core_pubmed_pmc | Development and validation of analytical method for the estimation of lamivudine in rabbit plasma | Development and validation of analytical method for the estimation of lamivudine in rabbit plasma Abstract Abstract Lamivudine has been widely used in the treatment of HIV disease. A reliable, sensitive reversed phase high performance liquid chromatography (RP-HPLC) method was developed and validated for lamivudine in ... |
PMC11285397 | core_pubmed_pmc | Smoking reduction using an electronic nicotine delivery system (ENDS) with nicotine delivery similar to combustible cigarettes | Smoking reduction using an electronic nicotine delivery system (ENDS) with nicotine delivery similar to combustible cigarettes Abstract Abstract Background Electronic nicotine delivery systems (ENDS) offer a promising approach to tobacco harm reduction, but many people use both ENDS and combustible cigarettes (“dual us... |
PMC7004556 | core_pubmed_pmc | First‐in‐human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors | First‐in‐human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors Abstract Abstract Fibroblast growth factor receptors (FGFR) are a family of transmembrane receptor tyrosine kinases involved in regulating cellular processes. FGFR mutations are i... |
PMC11060733 | core_pubmed_pmc | Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing | Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing Abstract Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable; however, designs suitable for clinical translation are needed. We designed a fully human, rapamycin-regulated drug produ... |
PMC9680514 | core_pubmed_pmc | Rates of Divergent Pharmacogenes in a Psychiatric Cohort of Inpatients with Depression—Arguments for Preemptive Testing | Rates of Divergent Pharmacogenes in a Psychiatric Cohort of Inpatients with Depression—Arguments for Preemptive Testing Abstract Background: The international drug agencies annotate pharmacogenes for many years. Pharmacogenetic testing is thus far only established in few settings, assuming that only few patients are ac... |
PMC8443777 | core_pubmed_pmc | Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of Erigeron breviscapus | Advances in Chemical Constituents, Clinical Applications, Pharmacology, Pharmacokinetics and Toxicology of Erigeron breviscapus Abstract Dengzhanxixin (DZXX), the dried whole plant of Erigeron breviscapus (Vaniot) Hand.-Mazz., belonging to Compositae and first published in Materia Medica of South Yunnan by Lan Mao in t... |
PMC9283706 | core_pubmed_pmc | Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs | Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs Abstract Abstract Among the advancements in drug structural modifications, the increased focus on drug metabolic and pharmacokinetic properties in the anesthetic drug design process has led to significant developments. Drug metabolism al... |
PMC11495198 | core_pubmed_pmc | Self-Nanoemulsifying Drug Delivery System of Morin: A New Approach for Combating Acute Alcohol Intoxication | Self-Nanoemulsifying Drug Delivery System of Morin: A New Approach for Combating Acute Alcohol Intoxication Abstract Abstract Purpose Acute alcohol intoxication (AAI) is a life-threatening medical condition resulting from excessive alcohol consumption. Our research revealed the potential of morin (MOR) in treating AAI.... |
PMC6349786 | core_pubmed_pmc | The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients | The potential impact of hematocrit correction on evaluation of tacrolimus target exposure in pediatric kidney transplant patients Abstract Background Tacrolimus is an important immunosuppressive agent with high intra- and inter-individual pharmacokinetic variability and a narrow therapeutic index. As tacrolimus extensi... |
PMC8861059 | core_pubmed_pmc | In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids | In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids Abstract X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, i... |
PMC10452719 | core_pubmed_pmc | Pharmacodynamic Model of the Dynamic Response of Pseudomonas aeruginosa Biofilms to Antibacterial Treatments | Pharmacodynamic Model of the Dynamic Response of Pseudomonas aeruginosa Biofilms to Antibacterial Treatments Abstract Abstract Accurate pharmacokinetic–pharmacodynamic (PK-PD) models of biofilm treatment could be used to guide formulation and administration strategies to better control bacterial lung infections. To thi... |
PMC10728507 | core_pubmed_pmc | Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice | Adrenaline auto injectors pharmacokinetic/pharmacodynamic studies and potential consequences for clinical practice Abstract Abstract Background Anaphylaxis is a sudden multisystem allergic reaction which may result in a fatal outcome if not treated promptly. Guidelines worldwide suggest intramuscular adrenaline as the ... |
PMC9355056 | core_pubmed_pmc | Dipeptidyl peptidase IV inhibition of phytocompounds from Artocarpus champeden (Lour.) Stokes: In silico molecular docking study and ADME-Tox prediction approach | Dipeptidyl peptidase IV inhibition of phytocompounds from Artocarpus champeden (Lour.) Stokes: In silico molecular docking study and ADME-Tox prediction approach Abstract ABSTRACT The present study examines the potential activity prediction based on free binding energy (ΔG) and interaction confirmation of phytocompound... |
PMC3996866 | core_pubmed_pmc | Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients | Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients Abstract Abstract Carbapenem-resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units. A... |
PMC8089108 | core_pubmed_pmc | Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP ® ) Biosimilar, to Those of NESP ® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects | Comparison of Pharmacokinetic, Pharmacodynamic and Tolerability Profiles of CKD-11101, Darbepoetin Alfa (NESP ® ) Biosimilar, to Those of NESP ® After a Single Subcutaneous or Intravenous Administration to Healthy Subjects Abstract Introduction Darbepoetin alfa (NESP ® and ARANESP ® ) has a sustained erythropoietic act... |
PMC8309192 | core_pubmed_pmc | Investigating Ex Vivo Animal Models to Test the Performance of Intravitreal Liposomal Drug Delivery Systems | Investigating Ex Vivo Animal Models to Test the Performance of Intravitreal Liposomal Drug Delivery Systems Abstract Abstract There is a strong need for innovative and efficient drug delivery systems for ocular therapy development. However, testing intravitreal drug delivery systems without using live animals is challe... |
PMC12066935 | core_pubmed_pmc | Plasma and Urine Pharmacokinetics of Long‐Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses | Plasma and Urine Pharmacokinetics of Long‐Acting Injectable Omeprazole Following Intramuscular Administrations to Healthy Thoroughbred Horses Abstract ABSTRACT Omeprazole is a gastric acid secretion inhibitor used as an effective anti‐ulcer drug. Based on oral administration studies, its International Screening Limit (... |
PMC7960760 | core_pubmed_pmc | Repurposing Treatment of Wernicke–Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile | Repurposing Treatment of Wernicke–Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile Abstract Coronavirus disease identified in 2019 (COVID-19) can be complicated by the Th17 cell-mediated IL-17 proin... |
PMC4082882 | core_pubmed_pmc | Quercetin Significantly Inhibits the Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP 1 A 2*1 C (−2964G>A) and *1 F (734C>A) Gene Polymorphisms | Quercetin Significantly Inhibits the Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP 1 A 2*1 C (−2964G>A) and *1 F (734C>A) Gene Polymorphisms Abstract Abstract Background . Quercetin is abundant in plants and human diets. Previous studies indicated that quercetin inhibited the activity of C... |
PMC12144534 | core_pubmed_pmc | The impact of sex on blood pressure | The impact of sex on blood pressure Abstract Purpose of review Hypertension is the most prevalent cardiovascular disease worldwide and the leading cause of mortality in both men and women. Despite well documented sex differences in prevalence, risk factors, and treatment responses, current guidelines still fail to take... |
PMC9825299 | core_pubmed_pmc | Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1 -mutant glioma: A multicenter, open-label, phase Ib/II trial | Olutasidenib (FT-2102) in patients with relapsed or refractory IDH1 -mutant glioma: A multicenter, open-label, phase Ib/II trial Abstract Abstract Background Olutasidenib (FT-2102) is a highly potent, orally bioavailable, brain-penetrant and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). The aim of th... |
PMC6058521 | core_pubmed_pmc | Multivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization | Multivesicular liposomes for sustained release of bevacizumab in treating laser-induced choroidal neovascularization Abstract Abstract Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have ... |
PMC2784073 | core_pubmed_pmc | Effect of apomorphine on cognitive performance and sensorimotor gating in humans | Effect of apomorphine on cognitive performance and sensorimotor gating in humans Abstract Introduction Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using... |
PMC4153977 | core_pubmed_pmc | Does a Hot Drink Provide Faster Absorption of Paracetamol Than a Tablet? A Pharmacoscintigraphic Study in Healthy Male Volunteers | Does a Hot Drink Provide Faster Absorption of Paracetamol Than a Tablet? A Pharmacoscintigraphic Study in Healthy Male Volunteers Abstract Purpose To investigate the hypothesis that paracetamol is absorbed faster from a hot drink than from a standard tablet using simultaneous scintigraphic imaging and pharmacokinetic s... |
PMC4959752 | core_pubmed_pmc | Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity | Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity Abstract 5-[(4-carboxybutanoyl)amino]-2-hydroxybenzoic acid ( C2 ) is a novel synthetic derivative of 5-aminosalicylic acid (5-ASA... |
PMC10515999 | core_pubmed_pmc | Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation | Anti-thymocyte globulin exposure in patients with diffuse cutaneous systemic sclerosis undergoing autologous haematopoietic stem cell transplantation Abstract Abstract Introduction: Autologous haematopoietic stem cell transplantation improves event-free survival and lung function and reduces skin thickening in patients... |
PMC12956365 | core_pubmed_pmc | A Phase 1b Study of Lenvatinib plus Nivolumab in Patients with Unresectable Hepatocellular Carcinoma | A Phase 1b Study of Lenvatinib plus Nivolumab in Patients with Unresectable Hepatocellular Carcinoma Abstract Abstract Introduction Despite recent advances in treatment for unresectable hepatocellular carcinoma (uHCC), median overall survival (OS) in the first-line setting across immune-based combination therapies has ... |
PMC8025786 | core_pubmed_pmc | Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom | Single-Arm, Multicenter Phase I/II Clinical Trial for the Treatment of Envenomings by Massive Africanized Honey Bee Stings Using the Unique Apilic Antivenom Abstract We evaluated the safety, optimal dose, and preliminary effectiveness of a new-approach Africanized honeybee ( Apis mellifera ) Antivenom (AAV) in a phase ... |
PMC8086052 | core_pubmed_pmc | The safety, tolerability and pharmacokinetics of niraparib in Japanese patients with solid tumours: results of a phase I dose-escalation study | The safety, tolerability and pharmacokinetics of niraparib in Japanese patients with solid tumours: results of a phase I dose-escalation study Abstract Abstract Background Niraparib is the only poly (adenosine diphosphate-ribose)-polymerase (PARP) inhibitor available as oral monotherapy for maintenance, regardless of B... |
PMC12053227 | core_pubmed_pmc | A translational physiologically-based pharmacokinetic model for MMAE-based antibody-drug conjugates | A translational physiologically-based pharmacokinetic model for MMAE-based antibody-drug conjugates Abstract The objective of this work was to develop a translational physiologically-based pharmacokinetic (PBPK) model for antibody-drug conjugates (ADCs), using monomethyl auristatin E (MMAE)-based ADCs. A previously est... |
PMC6442111 | core_pubmed_pmc | Development and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection | Development and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection Abstract Abstract Tacrolimus has been widely applied to prevent organ rejection after transplantation. However, the conventional pharmaceutical formulation of tacrolimus limits its applications in ocular therapy ... |
PMC6543330 | core_pubmed_pmc | The Pre-clinical Toolbox of Pharmacokinetics and Pharmacodynamics: in vitro and ex vivo Models | The Pre-clinical Toolbox of Pharmacokinetics and Pharmacodynamics: in vitro and ex vivo Models Abstract Prevention strategies against sexual transmission of human immunodeficiency virus (HIV) are essential to curb the rate of new infections. In the absence of a correlate of protection against HIV infection, pre-clinica... |
PMC9395488 | core_pubmed_pmc | First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors | First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors Abstract Preclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS). This first-in-... |
PMC5338049 | core_pubmed_pmc | Applications of polymers in intraocular drug delivery systems | Applications of polymers in intraocular drug delivery systems Abstract Abstract We are entering a new era of ophthalmic pharmacology where new drugs are rapidly being developed for the treatment of anterior and posterior segment of the eye disease. The pharmacokinetics of drug delivery to the eye remains a very active ... |
PMC9963565 | core_pubmed_pmc | Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma | Design, Characterization and Pharmacokinetic–Pharmacodynamic Evaluation of Poloxamer and Kappa-Carrageenan-Based Dual-Responsive In Situ Gel of Nebivolol for Treatment of Open-Angle Glaucoma Abstract Abstract This study developed a dual-responsive in situ gel of nebivolol (NEB), a selective β-adrenergic antagonist. The... |
PMC11847257 | core_pubmed_pmc | Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma | Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma Abstract Background In this report, we present results from studies of eribulin as monotherapy (Study 223) and in c... |
PMC10145603 | core_pubmed_pmc | Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery | Recent Advances in Biocompatible Ionic Liquids in Drug Formulation and Delivery Abstract The development of effective drug formulations and delivery systems for newly developed or marketed drug molecules remains a significant challenge. These drugs can exhibit polymorphic conversion, poor bioavailability, and systemic ... |
PMC8866912 | core_pubmed_pmc | Impact of polymorphisms of pharmacokinetics‐related genes and the inflammatory response on the metabolism of voriconazole | Impact of polymorphisms of pharmacokinetics‐related genes and the inflammatory response on the metabolism of voriconazole Abstract Abstract The effects of inflammatory responses and polymorphisms of the genes encoding cytochrome P450 (CYP) ( CYP2C19 and CYP3A5 ), flavin‐containing monooxygenase 3 ( FMO3 ), pregnane X r... |
PMC8658079 | core_pubmed_pmc | Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome—A Single Center Prospective Study | Anti-Xa Activity of Enoxaparin for Prevention of Venous Thromboembolism in Severe Nephrotic Syndrome—A Single Center Prospective Study Abstract Severe nephrotic syndrome (NS) is associated with high risk of venous thromboembolic events (VTE), as well as presumably altered heparin pharmacokinetics and pharmacodynamics. ... |
PMC7894405 | core_pubmed_pmc | A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans | A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans Abstract Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) outbreak initiated the global coronavirus disease 2019 (COVID‐19) pandemic resulting in 42.9 million confirmed... |
PMC7490523 | core_pubmed_pmc | A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers | A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Recombinant Human Hyaluronidase PH20 Administered Intravenously in Healthy Volunteers Abstract Abstract Background Recombinant human hyaluronidase PH20 (rHuPH20) is used in subcutaneous formulations (eg, RITUXAN HYCELA [ritu... |
PMC9468560 | core_pubmed_pmc | A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of inhaled ribavirin | A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of inhaled ribavirin Abstract Abstract Ribavirin is an inosine monophosphate dehydrogenase inhibitor. Studies suggest ribavirin aerosol could be a safe and efficacious treatment option in the fight against coronaviruses. However, current tre... |
PMC12775016 | core_pubmed_pmc | When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds | When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds Abstract Background The impact of acute subdural hematoma (aSDH) on measures of glymphatic–meningeal lymphatic function has not previously been reported. We present a descriptive observational study including a small case se... |
PMC4649706 | core_pubmed_pmc | Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response | Alpha-2-macroglobulin loaded microcapsules enhance human leukocyte functions and innate immune response Abstract Abstract Synthetic microstructures can be engineered to deliver bioactive compounds impacting on their pharmacokinetics and pharmacodynamics. Herein, we applied dextran-based layer-by-layer (LbL) microcapsul... |
PMC9272939 | core_pubmed_pmc | Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro / in vivo evaluation | Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro / in vivo evaluation Abstract Abstract Asthma represents a globally serious non-communicable ailment with significant public health outcomes for both pediatrics an... |
PMC10640380 | core_pubmed_pmc | FooDrugs: a comprehensive food–drug interactions database with text documents and transcriptional data | FooDrugs: a comprehensive food–drug interactions database with text documents and transcriptional data Abstract Abstract Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects ... |
PMC11371380 | core_pubmed_pmc | Long-term efficacy and safety of subcutaneous tocilizumab in clinical trials of polyarticular or systemic juvenile idiopathic arthritis | Long-term efficacy and safety of subcutaneous tocilizumab in clinical trials of polyarticular or systemic juvenile idiopathic arthritis Abstract Abstract Objective To investigate the safety and efficacy of subcutaneous tocilizumab (SC-TCZ) treatment in a long-term extension (LTE) of clinical trials in polyarticular or ... |
PMC6594083 | core_pubmed_pmc | Clinical pharmacology study of ipragliflozin in Japanese patients with type 1 diabetes mellitus: A phase 2, randomized, placebo‐controlled trial | Clinical pharmacology study of ipragliflozin in Japanese patients with type 1 diabetes mellitus: A phase 2, randomized, placebo‐controlled trial Abstract Abstract Aim To evaluate the pharmacodynamics, pharmacokinetics, and safety of the novel oral sodium‐glucose co‐transporter‐2 inhibitor, ipragliflozin, in Japanese pa... |
PMC6354225 | core_pubmed_pmc | Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer | Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer Abstract Abstract The prostate-specific membrane antigen (PSMA)–targeted radiotracers 68 Ga/ 177 Lu-PSMA-I&T and 99m Tc-PSMA-I&S (for i maging and s urgery) are currently succes... |
PMC12259427 | core_pubmed_pmc | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy Abstract Abstract Purpose It is well known that pharmacokinetics (PK) of drugs is significantly altered in sepsis patients receiving continuous renal replacement therapy (CRRT). However, c... |
PMC4532713 | core_pubmed_pmc | Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants | Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants Abstract Purpose Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing. This study investigates paracetamol clearan... |
PMC8858832 | core_pubmed_pmc | Pharmacokinetics of Esomeprazole in Critically Ill Patients | Pharmacokinetics of Esomeprazole in Critically Ill Patients Abstract Abstract Background Esomeprazole, a potent proton pump inhibitor (PPI), is widely used for the prevention of stress ulcers in intensive care unit (ICU) patients. Objective This study investigates the pharmacokinetics (PK) of esomeprazole in critically... |
PMC6836086 | core_pubmed_pmc | Population Pharmacokinetics of Cis -, Trans -, and Total Cefprozil in Healthy Male Koreans | Population Pharmacokinetics of Cis -, Trans -, and Total Cefprozil in Healthy Male Koreans Abstract Cefprozil, one of cephalosporin antibiotics, has been used extensively in clinics. However, pharmacokinetic (PK) information on cefprozil is still very limited. There have been no reports of population pharmacokinetics (... |
PMC7414938 | core_pubmed_pmc | Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions | Bioequivalence Study of Amitriptyline Hydrochloride Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions Abstract Purpose This study compares the pharmacokinetic and safety profiles between a new generic and a branded reference formulation of amitriptyline hydrochloride tablets, and assesses the bioeq... |
PMC7509523 | core_pubmed_pmc | Safety and efficacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial | Safety and efficacy of intravenous belimumab in children with systemic lupus erythematosus: results from a randomised, placebo-controlled trial Abstract Abstract Objectives This ongoing Phase-2, randomised, placebo-controlled, double-blind study evaluated the efficacy, safety and pharmacokinetics of intravenous belimum... |
PMC5414891 | core_pubmed_pmc | Impact of Physiologically Based Pharmacokinetic Models on Regulatory Reviews and Product Labels: Frequent Utilization in the Field of Oncology | Impact of Physiologically Based Pharmacokinetic Models on Regulatory Reviews and Product Labels: Frequent Utilization in the Field of Oncology Abstract Physiologically based pharmacokinetic (PBPK) modeling can be used to predict drug pharmacokinetics in virtual populations using models that integrate understanding of p... |
PMC4129930 | core_pubmed_pmc | Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System | Modified Titanium Implant as a Gateway to the Human Body: The Implant Mediated Drug Delivery System Abstract The aim of this study was to investigate the efficacy of a proposed new implant mediated drug delivery system (IMDDS) in rabbits. The drug delivery system is applied through a modified titanium implant that is c... |
PMC6155683 | core_pubmed_pmc | Pharmacokinetics Studies of 12 Alkaloids in Rat Plasma after Oral Administration of Zuojin and Fan-Zuojin Formulas | Pharmacokinetics Studies of 12 Alkaloids in Rat Plasma after Oral Administration of Zuojin and Fan-Zuojin Formulas Abstract Abstract Zuojin formula (ZJ) is a traditional Chinese medicine (TCM) prescription consisted of Coptidis Rhizoma (CR) and Euodiae Fructus (EF), and has been used to treat gastrointestinal (GI) dise... |
PMC12958104 | core_pubmed_pmc | Artificial lipidation of proteins and peptides: from mechanism to clinical applications | Artificial lipidation of proteins and peptides: from mechanism to clinical applications Abstract Abstract The landscape of modern medicine has been transformed by protein‐based therapeutics, offering targeted treatments for complex disorders with remarkable specificity and efficacy. However, these biologics face signif... |
PMC5899833 | core_pubmed_pmc | Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients | Population pharmacokinetics/pharmacodynamics of micafungin against Candida species in obese, critically ill, and morbidly obese critically ill patients Abstract Abstract Background Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and ... |
PMC12561008 | core_pubmed_pmc | Pharmacokinetics of Sofosbuvir and Velpatasvir for Hepatitis C Treatment in Pregnancy | Pharmacokinetics of Sofosbuvir and Velpatasvir for Hepatitis C Treatment in Pregnancy Abstract Abstract Background : Pregnancy is a time when women are uniquely engaged with the healthcare system and are often motivated to participate in activities directed toward improvement of their own health and ensuring the health... |
PMC11739129 | core_pubmed_pmc | Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma | Impact of Methotrexate and 7‐Hydroxymethotrexate Exposure on Renal Toxicity in Pediatric Non‐Hodgkin Lymphoma Abstract ABSTRACT Background 7‐Hydroxymethotrexate (7‐OHMTX) is the main metabolite in plasma following high‐dose MTX (HD‐MTX), which may result in activity and toxicity of the MTX. Moreover, 7‐OHMTX could prod... |
PMC8706398 | core_pubmed_pmc | Therapeutic Potential of Injectable Nano-Mupirocin Liposomes for Infections Involving Multidrug-Resistant Bacteria | Therapeutic Potential of Injectable Nano-Mupirocin Liposomes for Infections Involving Multidrug-Resistant Bacteria Abstract Abstract Antibiotic resistance is a global health threat. There are a few antibiotics under development, and even fewer with new modes of action and no cross-resistance to established antibiotics.... |
PMC11568265 | core_pubmed_pmc | Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate | Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate Abstract Asenapine maleate (ASPM) is a second-generation atypical antipsychotic that is approved for treating acute schizophre... |
PMC7708882 | core_pubmed_pmc | COVID-19 infection in a kidney transplant recipient—special emphasis on pharmacokinetic interactions: A case report | COVID-19 infection in a kidney transplant recipient—special emphasis on pharmacokinetic interactions: A case report Abstract Abstract BACKGROUND Solid organ transplant recipients are considered to be at high-risk of developing coronavirus disease 2019 (COVID-19)-related complications. The optimal treatment for this pat... |
PMC11354333 | core_pubmed_pmc | Three Years On: The Role of Pegcetacoplan in Paroxysmal Nocturnal Hemoglobinuria (PNH) since Its Initial Approval | Three Years On: The Role of Pegcetacoplan in Paroxysmal Nocturnal Hemoglobinuria (PNH) since Its Initial Approval Abstract Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease characterized by complement-mediated hemolysis and potentially life-threatening complications. Pegcetacoplan, an inhibitor of co... |
PMC12389255 | core_pubmed_pmc | Population Pharmacokinetics of Tideglusib in Congenital and Childhood Myotonic Dystrophy Type 1: Influence of Demographic and Clinical Factors on Systemic Exposure | Population Pharmacokinetics of Tideglusib in Congenital and Childhood Myotonic Dystrophy Type 1: Influence of Demographic and Clinical Factors on Systemic Exposure Abstract Background : GSK3β is an intracellular regulatory kinase that is dysregulated in multiple tissues in Type 1 myotonic dystrophy (DM-1). Tideglusib i... |
PMC7560740 | core_pubmed_pmc | Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use | Design and in vivo evaluation of a microparticulate depot formulation of buprenorphine for veterinary use Abstract Buprenorphine is a frequently used analgetic agent in veterinary medicine. A major drawback, however, is the short duration of action requiring several daily administrations. We therefore designed a poly-l... |
PMC7242285 | core_pubmed_pmc | JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study | JNJ-4178 (adafosbuvir, odalasvir, and simeprevir) in Japanese patients with chronic hepatitis C virus genotype 1 or 2 infection with or without compensated cirrhosis: the Phase IIa OMEGA-3 study Abstract Background The efficacy, safety, and pharmacokinetics of the combination of three direct-acting antiviral (DAA) agen... |
PMC9343941 | core_pubmed_pmc | Population Pharmacokinetics and Pharmacodynamics of Isoniazid and its Metabolite Acetylisoniazid in Chinese Population | Population Pharmacokinetics and Pharmacodynamics of Isoniazid and its Metabolite Acetylisoniazid in Chinese Population Abstract Objective: We aimed to establish a population pharmacokinetic (PPK) model for isoniazid (INH) and its major metabolite Acetylisoniazid (AcINH) in healthy Chinese participants and tuberculosis ... |
PMC12280725 | core_pubmed_pmc | Clinical pharmacokinetics of potassium competitive acid blockers: a systematic review and meta-analysis | Clinical pharmacokinetics of potassium competitive acid blockers: a systematic review and meta-analysis Abstract Background Potassium competitive acid blockers (P-CABs) are a new class of acid suppressants that provide rapid and sustained inhibition of gastric acid secretion. Understanding the pharmacokinetic (PK) char... |
PMC9379304 | core_pubmed_pmc | Population pharmacokinetic models of anti-PD-1 mAbs in patients with multiple tumor types: A systematic review | Population pharmacokinetic models of anti-PD-1 mAbs in patients with multiple tumor types: A systematic review Abstract Aims and background A number of population pharmacokinetic (PPK) models of anti-programmed cell death-1 (PD-1) monoclonal antibodies (mAbs) in multiple tumor types have been published to characterize ... |
PMC11222276 | core_pubmed_pmc | Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses | Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses Abstract Abstract Background and Objective Managing drug-food interactions is essential for optimizing the effectiveness and safety profile of quinolones. Following PRISMA guidelines... |
PMC4346873 | core_pubmed_pmc | Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae | Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae Abstract Abstract Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many... |
PMC9051964 | core_pubmed_pmc | Study of influence of Catha edulis (Khat) chewing on oral pharmacokinetics of irbesartan in rats using a newly developed HPLC-UV method | Study of influence of Catha edulis (Khat) chewing on oral pharmacokinetics of irbesartan in rats using a newly developed HPLC-UV method Abstract Khat consumers might use a number of drugs for underlying conditions; however the potential drug-herb interaction between khat and other drugs including Irbesartan (IRB) is un... |
PMC11580331 | core_pubmed_pmc | Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies | Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies Abstract The merging of physiology and toxicokinetics, or pharmacokinetics, with computational modeling to characterize dosimetry has led to major advances for both the chemical an... |
PMC6347888 | core_pubmed_pmc | Levetiracetam optimal dose-finding as first-line treatment for neonatal seizures occurring in the context of hypoxic-ischaemic encephalopathy (LEVNEONAT-1): study protocol of a phase II trial | Levetiracetam optimal dose-finding as first-line treatment for neonatal seizures occurring in the context of hypoxic-ischaemic encephalopathy (LEVNEONAT-1): study protocol of a phase II trial Abstract Introduction Therapeutic schedules for treating neonatal seizures remain elusive. First-line treatment with phenobarbit... |
PMC11530481 | core_pubmed_pmc | Computational Modelling of the Impact of Evaporation on In-Vitro Dermal Absorption | Computational Modelling of the Impact of Evaporation on In-Vitro Dermal Absorption Abstract Abstract Purpose Volatiles are common in personal care products and dermatological drugs. Determining the impact of evaporation of volatiles on skin permeation is crucial to evaluate and understand their delivery, bioavailabilit... |
PMC6956244 | core_pubmed_pmc | Noninvasive Assessment of Exosome Pharmacokinetics In Vivo: A Review | Noninvasive Assessment of Exosome Pharmacokinetics In Vivo: A Review Abstract Abstract Exosomes, intraluminal vesicles that contain informative DNA, RNA, proteins, and lipid membranes derived from the original donor cells, have recently been introduced to therapy and diagnosis. With their emergence as an alternative to... |
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