id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC8709051 | core_pubmed_pmc | Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of Vildagliptin: In Vitro and In Vivo Studies | Formulation of Lipid-Based Tableted Spray-Congealed Microparticles for Sustained Release of Vildagliptin: In Vitro and In Vivo Studies Abstract Abstract Spray-congealing (SPC) technology was utilized to prepare lipid-based microparticles (MP) capable of sustaining the release of Vildagliptin (VG) for use as a once-dail... |
PMC6153808 | core_pubmed_pmc | Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B | Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B Abstract Disfiguring skin lesions caused by several species of the Leishmania parasite characterize cutaneous leishmaniasis (CL). Successful treatment of CL with intravenous (... |
PMC10693922 | core_pubmed_pmc | Thoracic Epidural Anesthesia After a Transversus Abdominis Plane Block With Liposomal Bupivacaine in a Patient With Chronic Opioid Use: A Case Report | Thoracic Epidural Anesthesia After a Transversus Abdominis Plane Block With Liposomal Bupivacaine in a Patient With Chronic Opioid Use: A Case Report Abstract Abstract Liposomal bupivacaine is a long-acting local anesthetic drug that provides extended analgesia. A 45-year-old man with metastatic colon cancer and an int... |
PMC9388998 | core_pubmed_pmc | Nanocarriers for effective delivery: modulation of innate immunity for the management of infections and the associated complications | Nanocarriers for effective delivery: modulation of innate immunity for the management of infections and the associated complications Abstract Innate immunity is the first line of defense against invading pathogens. Innate immune cells can recognize invading pathogens through recognizing pathogen-associated molecular pa... |
PMC10818831 | core_pubmed_pmc | The Use of Population Pharmacokinetics to Extrapolate Food Effects from Human Adults and Beagle Dogs to the Pediatric Population Illustrated with Paracetamol as a Test Case | The Use of Population Pharmacokinetics to Extrapolate Food Effects from Human Adults and Beagle Dogs to the Pediatric Population Illustrated with Paracetamol as a Test Case Abstract Abstract To date, food–drug interactions in the pediatric population remain understudied. The current food effect studies are mostly perfo... |
PMC9905187 | core_pubmed_pmc | Cabozantinib exposure–response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma | Cabozantinib exposure–response analysis for the phase 3 CheckMate 9ER trial of nivolumab plus cabozantinib versus sunitinib in first-line advanced renal cell carcinoma Abstract Abstract Purpose In the phase 3 CheckMate 9ER trial, intravenous nivolumab (240 mg every 2 weeks) plus oral cabozantinib (40 mg/day) improved p... |
PMC10941576 | core_pubmed_pmc | Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia | Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia Abstract Abstract Model‐informed precision dosing using virtual twins (MIPD‐VTs) is an emerging strategy to predict target drug concentrations in clinical practice. Using a high virtualization MIPD‐VT appro... |
PMC10812549 | core_pubmed_pmc | Endotoxin-Induced Sepsis on Ceftriaxone-Treated Rats’ Ventilatory Mechanics and Pharmacokinetics | Endotoxin-Induced Sepsis on Ceftriaxone-Treated Rats’ Ventilatory Mechanics and Pharmacokinetics Abstract Sepsis can trigger acute respiratory distress syndrome (ARDS), which can lead to a series of physiological changes, modifying the effectiveness of therapy and culminating in death. For all experiments, male Wistar ... |
PMC3466827 | core_pubmed_pmc | Monitoring of Anticoagulant Therapy in Heart Disease: Considerations for the Current Assays | Monitoring of Anticoagulant Therapy in Heart Disease: Considerations for the Current Assays Abstract Clinicians should be aware of new developments to familiarize themselves with pharmacokinetic and pharmacodynamic characteristics of new anticoagulant agents to appropriately and safely use them. For the moment, cardiol... |
PMC12029500 | core_pubmed_pmc | Comparative Evaluation of Cytotoxic and Apoptotic Effects of Natural Compounds in SH-SY5Y Neuroblastoma Cells in Relation to Their Physicochemical Properties | Comparative Evaluation of Cytotoxic and Apoptotic Effects of Natural Compounds in SH-SY5Y Neuroblastoma Cells in Relation to Their Physicochemical Properties Abstract Abstract The cytotoxic and apoptotic properties of four bioactive natural compounds, the prenylated α-pyronephloroglucinol heterodimer arzanol (ARZ), the... |
PMC12520407 | core_pubmed_pmc | Phytochemical profiling and GC-MS analysis of bioactive compounds in methanolic crude extract of Beta vulgaris (BV) root from Bangladesh | Phytochemical profiling and GC-MS analysis of bioactive compounds in methanolic crude extract of Beta vulgaris (BV) root from Bangladesh Abstract Abstract Beta vulgaris (BV) is distributed worldwide and has long been used as a culinary and in traditional medicine to treat diseases. The objective of the present study wa... |
PMC5346141 | core_pubmed_pmc | Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice | Effect of sildenafil on the activity of some antidepressant drugs and electroconvulsive shock treatment in the forced swim test in mice Abstract Sildenafil, a potent and selective inhibitor of phosphodiesterase type 5, is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. It is often tak... |
PMC6441808 | core_pubmed_pmc | Preparation, characterization, and in vivo evaluation of a polymorphic form of valnemulin hydrogen tartrate | Preparation, characterization, and in vivo evaluation of a polymorphic form of valnemulin hydrogen tartrate Abstract Abstract We prepared a polymorphic form of valnemulin hydrogen tartrate (Form I) to overcome the instability and irritating odor of valnemulin hydrochloride that affect its use in the production and appl... |
PMC8847740 | core_pubmed_pmc | A Model Perspective Explanation of the Long-Term Sustainability of a Fully Human BCMA-Targeting CAR (CT103A) T-Cell Immunotherapy | A Model Perspective Explanation of the Long-Term Sustainability of a Fully Human BCMA-Targeting CAR (CT103A) T-Cell Immunotherapy Abstract Different from canonical drugs, CAR T-cells are “living drugs”, which derived from patient’s own blood. Studies of the pharmacokinetics of CAR T-cells could improve our understandin... |
PMC8054631 | core_pubmed_pmc | Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes | Durability of VEGF Suppression With Intravitreal Aflibercept and Brolucizumab: Using Pharmacokinetic Modeling to Understand Clinical Outcomes Abstract Purpose To investigate whether vascular endothelial growth factor (VEGF)–suppression durations contribute to our understanding of clinical trial outcomes by simulating v... |
PMC6942017 | core_pubmed_pmc | Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes | Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes Abstract IL-7 receptor-α (IL-7Rα) blockade has been shown to reverse autoimmune diabetes in the non-obese diabetic mou... |
PMC7567554 | core_pubmed_pmc | Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions | Pharmacokinetics and Bioequivalence of Two Formulations of Valsartan 80 mg Capsules: A Randomized, Single Dose, 4-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions Abstract Abstract Purpose To compare the bioequivalence of two formulations of valsartan (80 mg capsules) under fasting ... |
PMC12930014 | core_pubmed_pmc | Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study | Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study Abstract Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐s... |
PMC9820866 | core_pubmed_pmc | Bioanalytical Assay Strategies and Considerations for Measuring Cellular Kinetics | Bioanalytical Assay Strategies and Considerations for Measuring Cellular Kinetics Abstract Abstract A vast evolution of drug modalities has occurred over the last several decades. Novel modalities such as cell and gene therapies have proven to be efficacious for numerous clinical indications–primarily in rare disease a... |
PMC12114491 | core_pubmed_pmc | Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study | Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study Abstract Background: Esketamine is a rapidly acting antidepressant with robust efficacy in treatment-resistant depression (TRD). Diminishing therapeutic effects and attenuated side effects have been reported after long-... |
PMC6358182 | core_pubmed_pmc | Darunavir Population Pharmacokinetic Model Based on HIV Outpatient Data | Darunavir Population Pharmacokinetic Model Based on HIV Outpatient Data Abstract Supplemental Digital Content is Available in the Text. Key Words: pharmacokinetics, protease inhibitor, HIV-1 infection, therapeutic drug monitoring Abstract Background: Darunavir is a second-generation protease inhibitor and is registered... |
PMC10820640 | core_pubmed_pmc | An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma | An Intravenous Pharmacokinetic Study of Cannabidiol Solutions in Piglets through the Application of a Validated Ultra-High-Pressure Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for the Simultaneous Quantification of CBD and Its Carboxylated Metabolite in Plasma Abstract Cannabidiol (CBD) has multipl... |
PMC8520754 | core_pubmed_pmc | Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open‐source R package mapbayr | Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open‐source R package mapbayr Abstract Abstract Pharmacokinetic (PK) parameter estimation is a critical and complex step in the model‐informed precision dosing (MIPD) approach. The mapbayr package was developed to perform ... |
PMC12250628 | core_pubmed_pmc | Pharmacokinetics of Cannabidiol in Rat Brain Tissue After Single-Dose Administration of Different Formulations | Pharmacokinetics of Cannabidiol in Rat Brain Tissue After Single-Dose Administration of Different Formulations Abstract Cannabidiol (CBD), a phytocannabinoid commonly isolated from chemotype III Cannabis sativa plants, is known for its therapeutic potential. However, comprehensive information on its bioavailability is ... |
PMC9472132 | core_pubmed_pmc | Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy | Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy Abstract Abstract Background Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after t... |
PMC5516312 | core_pubmed_pmc | Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics | Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics Abstract The recognition of invading pathogens and endogenous molecules from damaged tissues by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However, exce... |
PMC9964951 | core_pubmed_pmc | Topical Application of Linezolid–Loaded Chitosan Nanoparticles for the Treatment of Eye Infections | Topical Application of Linezolid–Loaded Chitosan Nanoparticles for the Treatment of Eye Infections Abstract Abstract Linezolid (LZ) loaded chitosan–nanoparticles (CSNPs) was developed by the ionic–gelation method using Tripolyphosphate–sodium as a crosslinker for topical application for the treatment of bacterial eye i... |
PMC12629111 | core_pubmed_pmc | Pharmacokinetics of lopinavir/ritonavir in second-line treatment of children with HIV in the CHAPAS-4 trial | Pharmacokinetics of lopinavir/ritonavir in second-line treatment of children with HIV in the CHAPAS-4 trial Abstract Abstract Objective: Lopinavir/ritonavir (LPV/r) remains a much used drug combination for treatment of children with HIV, but pharmacokinetic data when the adult formulation (LPV/r 200/50 mg) is used for ... |
PMC8464813 | core_pubmed_pmc | A Novel Carbon Dots/Thermo-Sensitive In Situ Gel for a Composite Ocular Drug Delivery System: Characterization, Ex-Vivo Imaging, and In Vivo Evaluation | A Novel Carbon Dots/Thermo-Sensitive In Situ Gel for a Composite Ocular Drug Delivery System: Characterization, Ex-Vivo Imaging, and In Vivo Evaluation Abstract Abstract We developed a potential composite ocular drug delivery system for the topical administration of diclofenac sodium (DS). The novel carbon dot CD C-HP ... |
PMC11052801 | core_pubmed_pmc | Population Pharmacodynamic Dose–Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate | Population Pharmacodynamic Dose–Response Analysis of Serum Potassium Following Dosing with Sodium Zirconium Cyclosilicate Abstract Abstract Background Sodium zirconium cyclosilicate (SZC) is an approved oral treatment for hyperkalemia that selectively binds potassium (K + ) in the gastrointestinal tract and removes K +... |
PMC6126112 | core_pubmed_pmc | Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes | Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats by Protecting the Renal Podocytes Abstract Podocytes injury was a crucial factor resulting in diabetic nephropathy (DN). Erzhi formula extract (EZF) was a clinical effective Chinese medicine on DN, but its mechanism was unclear. In this study, the... |
PMC6595371 | core_pubmed_pmc | Pharmacokinetics, safety and tolerability of the novel β‐hCG derived immunomodulatory compound, EA‐230 | Pharmacokinetics, safety and tolerability of the novel β‐hCG derived immunomodulatory compound, EA‐230 Abstract Abstract Aims EA‐230 is a newly developed synthetic linear tetrapeptide (AQGV) derived from the chorionic gonadotropin hormone (β‐hCG). We investigated the pharmacokinetics, safety and tolerability of EA‐230 ... |
PMC6844228 | core_pubmed_pmc | Development Of Novel Liposome-Encapsulated Combretastatin A4 Acylated Derivatives: Prodrug Approach For Improving Antitumor Efficacy | Development Of Novel Liposome-Encapsulated Combretastatin A4 Acylated Derivatives: Prodrug Approach For Improving Antitumor Efficacy Abstract Abstract Purpose The objective of the present study was to develop a liposomal drug delivery system based on combretastatin A4 (CA4) prodrugs modified with varying alkyl chains a... |
PMC9144547 | core_pubmed_pmc | Comparison of Paliperidone Palmitate from Different Crystallization Processes and Effect on Formulations In Vitro and In Vivo | Comparison of Paliperidone Palmitate from Different Crystallization Processes and Effect on Formulations In Vitro and In Vivo Abstract Abstract The quality of active pharmaceutical ingredients (APIs) is an important factor which can affect the safety and efficacy of pharmaceuticals. This study was designed to investiga... |
PMC7683794 | core_pubmed_pmc | Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ Failure | Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ Failure Abstract Background: New treatment platforms that can prevent acute respiratory di... |
PMC8264498 | core_pubmed_pmc | Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers | Pharmacokinetic Modeling of Morphine’s Effect on Plasma Concentrations of Ticagrelor and Its Metabolite in Healthy Volunteers Abstract This study aimed to build a mathematical model describing the pharmacokinetics of ticagrelor and its active metabolite (AR-C124910XX) in a stable setting with concomitant administration... |
PMC9784852 | core_pubmed_pmc | Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review | Oral Pharmacokinetics of Hydroxycinnamic Acids: An Updated Review Abstract Abstract Hydroxycinnamic acids (HCAs) such as caffeic acid (CA), chlorogenic acid (CGA), coumaric acid (COA) isomers, ferulic acid (FA) and rosmarinic acid (RA) are natural phenolic acids with widespread distribution in vegetal foods and well-do... |
PMC8382995 | core_pubmed_pmc | Advances in flux balance analysis by integrating machine learning and mechanism-based models | Advances in flux balance analysis by integrating machine learning and mechanism-based models Abstract The availability of multi-omics data sets and genome-scale metabolic models for various organisms provide a platform for modeling and analyzing genotype-to-phenotype relationships. Flux balance analysis is the main too... |
PMC2912846 | core_pubmed_pmc | Treatment of CoQ 10 Deficient Fibroblasts with Ubiquinone, CoQ Analogs, and Vitamin C: Time- and Compound-Dependent Effects | Treatment of CoQ 10 Deficient Fibroblasts with Ubiquinone, CoQ Analogs, and Vitamin C: Time- and Compound-Dependent Effects Abstract Background Coenzyme Q 10 (CoQ 10 ) and its analogs are used therapeutically by virtue of their functions as electron carriers, antioxidant compounds, or both. However, published studies s... |
PMC5289534 | core_pubmed_pmc | NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease | NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease Abstract Abstract Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity... |
PMC10520114 | core_pubmed_pmc | Population Pharmacokinetic Analysis Supports Initiation Treatment and Bridging from Sublingual Buprenorphine to Subcutaneous Administration of a Buprenorphine Depot (CAM2038) in the Treatment of Opioid Use Disorder | Population Pharmacokinetic Analysis Supports Initiation Treatment and Bridging from Sublingual Buprenorphine to Subcutaneous Administration of a Buprenorphine Depot (CAM2038) in the Treatment of Opioid Use Disorder Abstract Abstract Background and Objective In treating opioid use disorder (OUD), subcutaneous (SC) exten... |
PMC6539736 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Models for CYP 1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam | Physiologically‐Based Pharmacokinetic Models for CYP 1A2 Drug–Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam Abstract This study provides whole‐body physiologically‐based pharmacokinetic models of the strong index cytochrome P450 ( CYP )1A2 inhibitor an... |
PMC12637173 | core_pubmed_pmc | Investigation on LASSBio‐1971 and LASSBio‐1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile | Investigation on LASSBio‐1971 and LASSBio‐1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile Abstract ABSTRACT Due to the arising of clinically relevant resistant EGFR‐related phenotype through innovative mechanisms, mainly EGFR L858R/T790M , the emergence of novel molecules with dual or multi‐target ... |
PMC10723574 | core_pubmed_pmc | Meropenem extraction by ex vivo extracorporeal life support circuits | Meropenem extraction by ex vivo extracorporeal life support circuits Abstract Background : Meropenem is a broad-spectrum carbapenem-type antibiotic commonly used to treat critically ill patients infected with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. As many of these patients require extracorpo... |
PMC6272519 | core_pubmed_pmc | Pharmacokinetics and Tissue Distribution Study of Caudatin in Normal and Diethylnitrosamine-Induced Hepatocellular Carcinoma Model Rats | Pharmacokinetics and Tissue Distribution Study of Caudatin in Normal and Diethylnitrosamine-Induced Hepatocellular Carcinoma Model Rats Abstract Abstract Caudatin is a potential antitumor agent isolated from the traditional Chinese medicine “ baishouwu ”, which was the root tuber of Cynanchum auriculatum Royle ex Wight... |
PMC12943293 | core_pubmed_pmc | Drivers of Methotrexate Polyglutamate Concentration in Erythrocytes: Insights from Immune-Mediated Inflammatory Diseases and Pediatric Acute Lymphoblastic Leukemia | Drivers of Methotrexate Polyglutamate Concentration in Erythrocytes: Insights from Immune-Mediated Inflammatory Diseases and Pediatric Acute Lymphoblastic Leukemia Abstract Abstract Background/Objectives : Methotrexate (MTX) is a cornerstone drug used to treat immune-mediated inflammatory diseases (IMIDs) in low doses ... |
PMC11926880 | core_pubmed_pmc | Procognitive Potential of Neuroprotective Triazine 5-HT 6 Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile | Procognitive Potential of Neuroprotective Triazine 5-HT 6 Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile Abstract Among serotonin receptors, the 5-HT 6 subtype is an important protein target and its ligands ma... |
PMC12463259 | core_pubmed_pmc | Stochastic treatment regimes in climate-health research: Reassessing malaria risk under warming scenarios in Colombia | Stochastic treatment regimes in climate-health research: Reassessing malaria risk under warming scenarios in Colombia Abstract Malaria remains a significant public health challenge, mainly because climate change is altering transmission dynamics. This study investigates the relationship between rising temperatures and ... |
PMC7767934 | core_pubmed_pmc | Efficacy and safety of apalutamide in Japanese patients with nonmetastatic castration-resistant prostate cancer: a subgroup analysis of a randomized, double-blind, placebo-controlled, Phase-3 study | Efficacy and safety of apalutamide in Japanese patients with nonmetastatic castration-resistant prostate cancer: a subgroup analysis of a randomized, double-blind, placebo-controlled, Phase-3 study Abstract Abstract Background In the global Phase-3 Selective Prostate Androgen Receptor Targeting with ARN-509 study, apal... |
PMC5559813 | core_pubmed_pmc | Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study | Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study Abstract Abstract Background Nausea is a subjective sensation which is difficult to measure in non-verbal species. The aims of this study were... |
PMC7235792 | core_pubmed_pmc | Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates | Effect of the Most Relevant CYP3A4 and CYP3A5 Polymorphisms on the Pharmacokinetic Parameters of 10 CYP3A Substrates Abstract Abstract Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced enzyme function. We aimed to evaluate the influence of these alleles on the pharmacokinetic parameters (PK... |
PMC11591679 | core_pubmed_pmc | Collagen I Microfiber Promotes Brain Capillary Network Formation in Three–Dimensional Blood–Brain Barrier Microphysiological Systems | Collagen I Microfiber Promotes Brain Capillary Network Formation in Three–Dimensional Blood–Brain Barrier Microphysiological Systems Abstract Background: The blood–brain barrier (BBB) strictly regulates the penetration of substances into the brain, which, although important for maintaining brain homeostasis, may delay ... |
PMC11250615 | core_pubmed_pmc | Very low monomethyl fumarate exposure via human milk: a case report—a contribution from the ConcePTION project | Very low monomethyl fumarate exposure via human milk: a case report—a contribution from the ConcePTION project Abstract Introduction While breastfeeding is recommended, knowledge regarding medicine transfer to human milk and its safety for nursing infants is limited. Only one paper has previously described dimethyl fum... |
PMC5849655 | core_pubmed_pmc | In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics | In vitro studies and in silico predictions of fluconazole and CYP2C9 genetic polymorphism impact on siponimod metabolism and pharmacokinetics Abstract Abstract Purpose The purpose of the study is to investigate the enzyme(s) responsible for siponimod metabolism and to predict the inhibitory effects of fluconazole as we... |
PMC9554867 | core_pubmed_pmc | Adherence to metformin in adults with type 2 diabetes: a combined method approach | Adherence to metformin in adults with type 2 diabetes: a combined method approach Abstract Background Medication adherence, one of the most important aspects in the process of optimal medicines use, is unfortunately still a major challenge in modern healthcare, and further research is required into how adherence can be... |
PMC7642756 | core_pubmed_pmc | Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues | Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues Abstract Abstract Since coronavirus disease 2019 (COVID-19) started as a fast-spreading pandemic, causing a huge number of deaths worldwide, several therapeutic options have been tested to counteract or reduce the clinical symptom... |
PMC11281481 | core_pubmed_pmc | Safety and Efficacy of Antiviral Drugs and Vaccines in Pregnant Women: Insights from Physiologically Based Pharmacokinetic Modeling and Integration of Viral Infection Dynamics | Safety and Efficacy of Antiviral Drugs and Vaccines in Pregnant Women: Insights from Physiologically Based Pharmacokinetic Modeling and Integration of Viral Infection Dynamics Abstract Abstract Addressing the complexities of managing viral infections during pregnancy is essential for informed medical decision-making. T... |
PMC12300890 | core_pubmed_pmc | Marine-Derived Compounds: A New Horizon in Cancer, Renal, and Metabolic Disease Therapeutics | Marine-Derived Compounds: A New Horizon in Cancer, Renal, and Metabolic Disease Therapeutics Abstract Abstract Marine-derived compounds represent a rich source of structurally diverse molecules with therapeutic potential for cancer, renal disorders, metabolic-associated fatty liver disease (MAFLD), and atherosclerosis.... |
PMC12683522 | core_pubmed_pmc | Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment | Bioequivalence of a single dose of two palbociclib formulations in healthy Chinese subjects under fasting conditions: a two-period crossover study with rabeprazole pre-treatment Abstract Abstract Objectives This study assessed the pharmacokinetics, safety, and bioequivalence of generic and original palbociclib tablets ... |
PMC9576339 | core_pubmed_pmc | A Novel Dextran-Based Dual Drug Conjugate Targeted Tumors with High Biodistribution Ratio of Tumors to Normal Tissues | A Novel Dextran-Based Dual Drug Conjugate Targeted Tumors with High Biodistribution Ratio of Tumors to Normal Tissues Abstract Purpose Most chemotherapeutic agents possess poor water solubility and show more significant accumulations in normal tissues than in tumor tissues, resulting in serious side effects. To this en... |
PMC3702484 | core_pubmed_pmc | Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer | Comparison of capecitabine and 5-fluorouracil in chemoradiotherapy for locally advanced pancreatic cancer Abstract Abstract Background Although capecitabine has theoretical advantages in the pharmacokinetics, such as higher intratumoral and lower systemic concentration, relative to bolus 5-fluorouracil (5-FU), outcomes... |
PMC4260869 | core_pubmed_pmc | Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-Induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment | Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-Induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment Abstract Abstract Focused ultrasound (FUS) exposure with the presence of microbubbles has been shown to transiently open the blood-brain barrier (BBB), and thus ... |
PMC6143933 | core_pubmed_pmc | An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagers | An opportunity for clinical pharmacology trained physicians to improve patient drug safety: A retrospective analysis of adverse drug reactions in teenagers Abstract Background: Adverse drug reactions (ADRs) are a major cause of hospital admissions, prolonged hospital stays, morbidity, and drug-related mortality. In thi... |
PMC6907258 | core_pubmed_pmc | Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma | Development of a prognostic composite cytokine signature based on the correlation with nivolumab clearance: translational PK/PD analysis in patients with renal cell carcinoma Abstract Background Although several therapeutic options for patients with renal cell carcinoma (RCC) have been approved over recent years, inclu... |
PMC12558385 | core_pubmed_pmc | Current progress of 1,2,3-triazole hybrids as EGFR inhibitors for cancer therapy – a literature review | Current progress of 1,2,3-triazole hybrids as EGFR inhibitors for cancer therapy – a literature review Abstract Epidermal growth factor receptor (EGFR) is a validated oncogenic driver in numerous solid tumors, and resistance to first- and second-generation tyrosine kinase inhibitors continues to limit clinical outcomes... |
PMC5883975 | core_pubmed_pmc | Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection | Serum Triamcinolone Levels following Cervical Interlaminar Epidural Injection Abstract Abstract Background Cervical interlaminar epidural steroid injections (ESIs) are commonly performed procedures to treat painful cervical radiculopathy, but little is known about the systemic absorption and serum levels of steroids fo... |
PMC7712059 | core_pubmed_pmc | Modeling Invasive Aspergillosis: How Close Are Predicted Antifungal Targets? | Modeling Invasive Aspergillosis: How Close Are Predicted Antifungal Targets? Abstract Abstract Animal model systems are a critical component of the process of discovery and development of new antifungal agents for treatment and prevention of invasive aspergillosis. The persistently neutropenic rabbit model of invasive ... |
PMC5874837 | core_pubmed_pmc | Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use | Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use Abstract Abstract Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). N... |
PMC12539412 | core_pubmed_pmc | Population Pharmacokinetic and Pharmacodynamic Modeling Analysis of rhIL-7-hyFc, a Hybrid Fc-Fused Long-Acting Interleukin-7, to Support Optimal Dosing Regimens in Patients with Solid Cancer | Population Pharmacokinetic and Pharmacodynamic Modeling Analysis of rhIL-7-hyFc, a Hybrid Fc-Fused Long-Acting Interleukin-7, to Support Optimal Dosing Regimens in Patients with Solid Cancer Abstract Purpose rhIL-7-hyFc (Efineptakin alfa) is a novel, long-acting recombinant human interleukin-7 developed to enhance immu... |
PMC9621318 | core_pubmed_pmc | Machine learning advances the integration of covariates in population pharmacokinetic models: Valproic acid as an example | Machine learning advances the integration of covariates in population pharmacokinetic models: Valproic acid as an example Abstract Abstract Background and Aim: Many studies associated with the combination of machine learning (ML) and pharmacometrics have appeared in recent years. ML can be used as an initial step for f... |
PMC11546339 | core_pubmed_pmc | Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt | Conformational Plasticity Enhances the Brain Penetration of a Metabolically Stable, Dual-Functional Opioid-Peptide CycloAnt Abstract Abstract CycloAnt is an opioid peptide that produces potent and efficacious antinociception with significantly reduced side effects upon systemic administration in mice. To verify its CNS... |
PMC3573743 | core_pubmed_pmc | In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa | In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa Abstract The development of an anti-bacterial drug in the form of a monoclonal antibody (mAb) targeting an exposed virulence factor, represents an innovative therapeutic strategy. Consequent... |
PMC10014062 | core_pubmed_pmc | Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species | Gene expression databases for physiologically based pharmacokinetic modeling of humans and animal species Abstract Abstract In drug research, developing a sound understanding of the key mechanistic drivers of pharmacokinetics (PK) for new molecular entities is essential for human PK and dose predictions. Here, characte... |
PMC3990489 | core_pubmed_pmc | Impact of Different Oseltamivir Regimens on Treating Influenza A Virus Infection and Resistance Emergence: Insights from a Modelling Study | Impact of Different Oseltamivir Regimens on Treating Influenza A Virus Infection and Resistance Emergence: Insights from a Modelling Study Abstract Several studies have proven oseltamivir to be efficient in reducing influenza viral titer and symptom intensity. However, the usefulness of oseltamivir can be compromised b... |
PMC8844171 | core_pubmed_pmc | Safety, Pharmacokinetics and Pharmacodynamics of DS-1040, in Combination with Thrombectomy, in Japanese Patients with Acute Ischemic Stroke | Safety, Pharmacokinetics and Pharmacodynamics of DS-1040, in Combination with Thrombectomy, in Japanese Patients with Acute Ischemic Stroke Abstract Abstract Background and Objectives DS-1040 is a novel inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor that may have therapeutic potential in... |
PMC8227119 | core_pubmed_pmc | Urinary Elimination of Ecdysterone and Its Metabolites Following a Single-Dose Administration in Humans | Urinary Elimination of Ecdysterone and Its Metabolites Following a Single-Dose Administration in Humans Abstract Abstract Ecdysterone is a phytosteroid widely discussed for its various pharmacological, growth-promoting, and anabolic effects, mediated by the activation of estrogen receptor beta (ERbeta). Performance-enh... |
PMC5496343 | core_pubmed_pmc | Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women | Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women Abstract Background Pregnancy has considerable effects on the pharmacokinetic properties of drugs used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic variation on anti-ma... |
PMC10304583 | core_pubmed_pmc | Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout ( Oncorhynchus mykiss ) following Oral Administration | Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout ( Oncorhynchus mykiss ) following Oral Administration Abstract Abstract Simple Summary Doxycycline, an approved aquacultural antibiotic, is extensively used in the treatment of bacterial diseases in fis... |
PMC11945303 | core_pubmed_pmc | Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data | Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data Abstract Abstract MK-6194, an interleukin-2 mutein designed to selectively activate regulatory T cells (Tregs), was evaluated for sa... |
PMC9047675 | core_pubmed_pmc | Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis | Omadacycline pharmacokinetics and soft-tissue penetration in diabetic patients with wound infections and healthy volunteers using in vivo microdialysis Abstract Abstract Objectives We assessed the plasma and soft-tissue pharmacokinetic exposure of omadacycline in infected patients with diabetic foot infection (DFI) and... |
PMC11770492 | core_pubmed_pmc | Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons | Pharmacokinetics of difloxacin after single intravenous, oral and intramuscular administration in pigeons Abstract This study aimed to investigate the pharmacokinetics of difloxacin in pigeons following oral ( PO ), intramuscular ( IM ), and intravenous ( IV ) administration. Thirty pigeons were randomly divided into t... |
PMC10927247 | core_pubmed_pmc | Hypoxia‐activated ADCC‐enhanced humanized anti‐CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity | Hypoxia‐activated ADCC‐enhanced humanized anti‐CD147 antibody for liver cancer imaging and targeted therapy with improved selectivity Abstract Abstract Therapeutic antibodies (Abs) improve the clinical outcome of cancer patients. However, on‐target off‐tumor toxicity limits Ab‐based therapeutics. Cluster of differentia... |
PMC10582665 | core_pubmed_pmc | A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of ART‐001 with a novel oral pediatric formulation in healthy subjects | A randomized, placebo‐controlled study to evaluate safety and pharmacokinetics of ART‐001 with a novel oral pediatric formulation in healthy subjects Abstract Abstract ART‐001 is an orally available selective PI3Kα inhibitor currently being developed for the treatment of slow‐flow vascular malformations (SFVMs). ART‐00... |
PMC9241727 | core_pubmed_pmc | Evaluating Mono- and Combination Therapy of Meropenem and Amikacin against Pseudomonas aeruginosa Bacteremia in the Hollow-Fiber Infection Model | Evaluating Mono- and Combination Therapy of Meropenem and Amikacin against Pseudomonas aeruginosa Bacteremia in the Hollow-Fiber Infection Model Abstract ABSTRACT Debate continues as to the role of combination antibiotic therapy for the management of Pseudomonas aeruginosa infections. We studied the extent of bacterial... |
PMC12823310 | core_pubmed_pmc | Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation | Integrating Population Approaches With Physiologically Based Pharmacokinetic Models: A Novel Framework for Parameter Estimation Abstract ABSTRACT Physiologically Based Pharmacokinetic (PBPK) modeling is a powerful tool in drug development that integrates drug‐specific information with physiological parameters to predic... |
PMC11313610 | core_pubmed_pmc | Clinical Significance and Patterns of Potential Drug–Drug Interactions in Cardiovascular Patients: Focus on Low-Dose Aspirin and Angiotensin-Converting Enzyme Inhibitors | Clinical Significance and Patterns of Potential Drug–Drug Interactions in Cardiovascular Patients: Focus on Low-Dose Aspirin and Angiotensin-Converting Enzyme Inhibitors Abstract Objective : This study assessed the patterns and clinical significance of potential drug–drug interactions (pDDIs) in patients with diseases ... |
PMC12486823 | core_pubmed_pmc | Safety, pharmacokinetics, and pharmacodynamics of human interferon-α2b spray in healthy participants | Safety, pharmacokinetics, and pharmacodynamics of human interferon-α2b spray in healthy participants Abstract ABSTRACT The safety, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple doses of human interferon (IFN)-α2b spray administered via nasal and oropharyngeal routes were evaluated in a randomized, double... |
PMC12127131 | core_pubmed_pmc | In Silico, In Vitro, and In Vivo Investigations of Anticancer Properties of a Novel Platinum (II) Complex and Its PLGA Encapsulated Form | In Silico, In Vitro, and In Vivo Investigations of Anticancer Properties of a Novel Platinum (II) Complex and Its PLGA Encapsulated Form Abstract Abstract In recent years, the development of multinuclear platinum complexes has introduced a new era in platinum-based chemotherapy, offering improved cytotoxicity and the a... |
PMC7067890 | core_pubmed_pmc | Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity | Processing and Polyherbal Formulation of Tetradium ruticarpum (A. Juss.) Hartley: Phytochemistry, Pharmacokinetics, and Toxicity Abstract Herbal medicine is a major part of traditional Chinese medicine (TCM), which is evolved as a system of medical practice from ancient China. The use of herbal medicine is mainly based... |
PMC7004020 | core_pubmed_pmc | Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal seizures or generalized tonic‐clonic seizures | Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12 years) with inadequately controlled focal seizures or generalized tonic‐clonic seizures Abstract Abstract Objective Study 311 ( NCT02849626 ) was a global, multicenter, open‐label, single‐arm study that asse... |
PMC7363835 | core_pubmed_pmc | The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort | The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort Abstract Abstract Warfarin is a frequently prescribed oral anticoagulant with a narrow therapeutic index, requiring careful dosing and monitoring. However, patients respond with significant inter-ind... |
PMC12445756 | core_pubmed_pmc | Impact of ageing on sevoflurane’s hypnotic potency and induction kinetics during wash-in period: A prospective observational study | Impact of ageing on sevoflurane’s hypnotic potency and induction kinetics during wash-in period: A prospective observational study Abstract Abstract Background and Aims: The age-dependent decline in sevoflurane’s minimum alveolar concentration is well established. However, the relationship between ageing and its hypnot... |
PMC11074935 | core_pubmed_pmc | Factors contributing to variability in metformin concentration in polycystic ovary syndrome | Factors contributing to variability in metformin concentration in polycystic ovary syndrome Abstract Aim To investigate the factors affecting metformin concentrations after chronic administration in patients with polycystic ovary syndrome (PCOS), focusing on the pharmacokinetic variability and its implications for pers... |
PMC4133921 | core_pubmed_pmc | Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant | Basic Aspects of the Pharmacodynamics of Tolperisone, A Widely Applicable Centrally Acting Muscle Relaxant Abstract Abstract Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicab... |
PMC6334931 | core_pubmed_pmc | Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients | Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients Abstract Abstract Background Flubendazole, originally developed to treat infections with intestinal nematodes, has been shown to be efficacious in animal models... |
PMC9790930 | core_pubmed_pmc | A randomized, double-blind, placebo-controlled phase I trial of inhalation treatment of recombinant TFF2-IFN protein: A multifunctional candidate for the treatment of COVID-19 | A randomized, double-blind, placebo-controlled phase I trial of inhalation treatment of recombinant TFF2-IFN protein: A multifunctional candidate for the treatment of COVID-19 Abstract Background and Objectives: Coronavirus disease 2019 (COVID-19) has caused global pandemics in the last 3 years, and the development of ... |
PMC5424195 | core_pubmed_pmc | Ex Vivo and In Vivo Characterization of Interpolymeric Blend/Nanoenabled Gastroretentive Levodopa Delivery Systems | Ex Vivo and In Vivo Characterization of Interpolymeric Blend/Nanoenabled Gastroretentive Levodopa Delivery Systems Abstract Abstract One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances o... |
PMC5762083 | core_pubmed_pmc | Local Radiotherapy Affects Drug Pharmacokinetics—Exploration of a Neglected but Significant Uncertainty of Cancer Therapy | Local Radiotherapy Affects Drug Pharmacokinetics—Exploration of a Neglected but Significant Uncertainty of Cancer Therapy Abstract Abstract Purpose: Concurrent chemoradiation therapy is the mainstay of treatment for many types of malignancies. However, concurrent chemoradiation therapy is associated with a greater numb... |
PMC11015086 | core_pubmed_pmc | Population pharmacokinetic modeling of oral brepocitinib in healthy volunteers and patients with immuno‐inflammatory diseases | Population pharmacokinetic modeling of oral brepocitinib in healthy volunteers and patients with immuno‐inflammatory diseases Abstract Abstract The objective of this population pharmacokinetic (PK) analysis was to characterize the concentration–time profile of brepocitinib plasma concentration after single‐ and multipl... |
PMC12960560 | core_pubmed_pmc | Effects of sleeve gastrectomy on rivaroxaban pharmacokinetics, efficacy, and safety | Effects of sleeve gastrectomy on rivaroxaban pharmacokinetics, efficacy, and safety Abstract Abstract Background Thromboembolic events are potentially serious complications in patients undergoing bariatric surgery. Several studies have investigated the use of rivaroxaban in patients undergoing bariatric surgery. Furthe... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.