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PMC4513234 | core_pubmed_pmc | In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves | In vivo antimicrobial activity of marbofloxacin against Pasteurella multocida in a tissue cage model in calves Abstract Abstract Marbofloxacin is a fluoroquinolone specially developed for use in veterinary medicine with broad-spectrum antibacterial activity. The objective of our study was to re-evaluate in vivo antimic... |
PMC9427971 | core_pubmed_pmc | Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers | Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers Abstract Abstract Background Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving ... |
PMC10456450 | core_pubmed_pmc | Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration | Pharmacokinetics of Danofloxacin in Gushi Chickens after Single Oral and Intravenous Administration Abstract This study aimed to determine the pharmacokinetics of danofloxacin in Gushi chickens after a single oral (PO) and intravenous (IV) dose at 5 mg/kg body weight (BW). Thirty-two Gushi chickens, aged 20 weeks, were... |
PMC5897409 | core_pubmed_pmc | Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice | Differential effect of morphine on gastrointestinal transit, colonic contractions and nerve-evoked relaxations in Toll-Like Receptor deficient mice Abstract Toll-like receptors (TLRs) are expressed in enteric neurons, glia, gastrointestinal (GI) smooth muscle and mucosa, yet their functional roles in the GI tract are n... |
PMC10751856 | core_pubmed_pmc | A descriptive pharmacokinetic/pharmacodynamic analysis of ceftazidime‐avibactam in a case series of critically ill patients with augmented renal clearance | A descriptive pharmacokinetic/pharmacodynamic analysis of ceftazidime‐avibactam in a case series of critically ill patients with augmented renal clearance Abstract Abstract To describe the pharmacokinetics/pharmacodynamics (PK/PD) of a 2 h infusion of ceftazidime‐avibactam (CAZ‐AVI) in critically ill patients with augm... |
PMC4621714 | core_pubmed_pmc | Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update | Ticagrelor: Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Profile: An Update Abstract Despite advancements in treatments for acute coronary syndromes over the last 10 years, they continue to be life-threatening disorders. Currently, the standard of treatment includes dual antiplatelet therapy consisting of aspir... |
PMC8376135 | core_pubmed_pmc | Population pharmacokinetic and exposure–response analyses of intravenous and subcutaneous rituximab in patients with chronic lymphocytic leukemia | Population pharmacokinetic and exposure–response analyses of intravenous and subcutaneous rituximab in patients with chronic lymphocytic leukemia Abstract Abstract A subcutaneous formulation of the anti‐CD20 antibody rituximab has been developed. Fixed‐dose subcutaneous rituximab delivers noninferior serum trough conce... |
PMC6391590 | core_pubmed_pmc | Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial | Iduronate-2-Sulfatase with Anti-human Transferrin Receptor Antibody for Neuropathic Mucopolysaccharidosis II: A Phase 1/2 Trial Abstract Hunter syndrome (mucopolysaccharidosis II [MPS II]), a deficiency of iduronate-2-sulfatase (IDS), causes an accumulation of glycosaminoglycans, giving rise to multiple systemic and CN... |
PMC8944851 | core_pubmed_pmc | Interprofessional Collaboration between ICU Physicians, Staff Nurses, and Hospital Pharmacists Optimizes Antimicrobial Treatment and Improves Quality of Care and Economic Outcome | Interprofessional Collaboration between ICU Physicians, Staff Nurses, and Hospital Pharmacists Optimizes Antimicrobial Treatment and Improves Quality of Care and Economic Outcome Abstract Abstract (1) Background: Antibiotic resistance is a worldwide health threat. The WHO published a global strategic plan in 2001 to co... |
PMC10440845 | core_pubmed_pmc | Clinical outcomes of chemotherapy in cancer patients with different ethnicities | Clinical outcomes of chemotherapy in cancer patients with different ethnicities Abstract Abstract Background Choosing the most effective chemotherapeutic agent with safest side effect profile is a common challenge in cancer treatment. Although there are standardized chemotherapy protocols in place, protocol changes mad... |
PMC4448983 | core_pubmed_pmc | Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses | Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses Abstract Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in... |
PMC8843208 | core_pubmed_pmc | Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy | Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy Abstract Abstract The traditional systemic chemotherapy through intravenous infusion of doxorubicin (DOX) has many side effects. The aim of this study was to develop a PLGA-based DOX-loaded implant and to evaluate the effi... |
PMC10324072 | core_pubmed_pmc | Molecular Representations in Machine-Learning-Based Prediction of PK Parameters for Insulin Analogs | Molecular Representations in Machine-Learning-Based Prediction of PK Parameters for Insulin Analogs Abstract Therapeutic peptides and proteins derived from either endogenous hormones, such as insulin, or de novo design via display technologies occupy a distinct pharmaceutical space in between small molecules and large ... |
PMC4206209 | core_pubmed_pmc | Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study | Lack of effect of ezogabine/retigabine on the pharmacokinetics of digoxin in healthy individuals: results from a drug–drug interaction study Abstract Introduction The potential for ezogabine/retigabine (EZG/RTG) and its N -acetyl metabolite (NAMR) to inhibit the transporter protein P-glycoprotein-(P-gp)-mediated digoxi... |
PMC12398224 | core_pubmed_pmc | Evaluation of the Safety and Pharmacokinetics of Single‐Dose Oral Probenecid Administration in Healthy Dogs | Evaluation of the Safety and Pharmacokinetics of Single‐Dose Oral Probenecid Administration in Healthy Dogs Abstract ABSTRACT Background Grape‐induced acute kidney injury (AKI) is caused by tartaric acid and may lead to death in dogs. Probenecid, an organic anion transporter‐1 inhibitor, recently has been shown to bloc... |
PMC5355170 | core_pubmed_pmc | Unveiling changes in the landscape of patient populations in cancer early drug development | Unveiling changes in the landscape of patient populations in cancer early drug development Abstract Abstract The introduction of new Molecularly Targeted Agents (MTA) has changed the landscape in Early Drug Development (EDD) over the last two decades, leading to an improvement in clinical trial design. Previous Phase 1... |
PMC12833461 | core_pubmed_pmc | Cycloastragenol in inflammation-related diseases: mechanisms, pharmacokinetics, and translational prospects | Cycloastragenol in inflammation-related diseases: mechanisms, pharmacokinetics, and translational prospects Abstract Abstract Chronic inflammation, driven by dysregulated immune responses and oxidative stress, underlies the pathogenesis of numerous diseases, from neurodegeneration to cancer. Cycloastragenol (CAG), a bi... |
PMC7169407 | core_pubmed_pmc | Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study | Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study Abstract Abstract This work demonstrated a sensitive, selective, and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitation... |
PMC12632117 | core_pubmed_pmc | Decoding multicomponent crosstalk: integrated pharmacodynamic‒pharmacokinetic network of sour jujube seed | Decoding multicomponent crosstalk: integrated pharmacodynamic‒pharmacokinetic network of sour jujube seed Abstract Abstract Ziziphus jujuba var. spinosa seed (SJS) is a multicomponent traditional remedy with diverse pharmacological activities, including sedative, neuroprotective, anxiolytic, and cardiometabolic effects... |
PMC9696414 | core_pubmed_pmc | Pharmacokinetics and Biological Activity of Cucurbitacins | Pharmacokinetics and Biological Activity of Cucurbitacins Abstract Abstract Cucurbitacins are a class of secondary metabolites initially isolated from the Cucurbitaceae family. They are important for their analgesic, anti-inflammatory, antimicrobial, antiviral, and anticancer biological actions. This review addresses p... |
PMC10701780 | core_pubmed_pmc | The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78 / BiP to induce unfolded protein response‐mediated apoptosis in myeloma | The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78 / BiP to induce unfolded protein response‐mediated apoptosis in myeloma Abstract Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anticancer properties. A recently developed SOT, 1‐[2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oyl]‐4(‐pyridin‐... |
PMC6004620 | core_pubmed_pmc | Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study | Simultaneous determination of acetaminophen and oxycodone in human plasma by LC–MS/MS and its application to a pharmacokinetic study Abstract Abstract A simple and rapid liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for simultaneous determination of acetaminophen and oxyco... |
PMC12219357 | core_pubmed_pmc | Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial | Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial Abstract Iatrogenic nerve injury is a surgical complication with significant morbidity. This clinical trial, now complete, investigates the systemic administration of bevonescein, which selectively binds to nerves, in a s... |
PMC4356883 | core_pubmed_pmc | Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients | Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients Abstract Abstract Background Volume of distribution is an important pharmacokinetic property that indicates the extent of a drug’s distribution in the body tissues. This paper addresses the... |
PMC9331678 | core_pubmed_pmc | A High-Throughput Clinical Laboratory Methodology for the Therapeutic Monitoring of Ibrutinib and Dihydrodiol Ibrutinib | A High-Throughput Clinical Laboratory Methodology for the Therapeutic Monitoring of Ibrutinib and Dihydrodiol Ibrutinib Abstract Abstract Ibrutinib (IBR) is an oral anticancer medication that inhibits Bruton tyrosine kinase irreversibly. Due to the high risk of adverse effects and its pharmacokinetic variability, the s... |
PMC6626639 | core_pubmed_pmc | Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council | Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council Abstract Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society.... |
PMC4488783 | core_pubmed_pmc | The Potential for Zinc Stable Isotope Techniques and Modelling to Determine Optimal Zinc Supplementation | The Potential for Zinc Stable Isotope Techniques and Modelling to Determine Optimal Zinc Supplementation Abstract Abstract It is well recognised that zinc deficiency is a major global public health issue, particularly in young children in low-income countries with diarrhoea and environmental enteropathy. Zinc supplemen... |
PMC11446860 | core_pubmed_pmc | Optimizing tacrolimus dosing in Hispanic renal transplant patients: insights from real-world data | Optimizing tacrolimus dosing in Hispanic renal transplant patients: insights from real-world data Abstract Abstract Aim Tacrolimus, an immunosuppressant used to prevent organ rejection in renal transplant patients, exhibits high inter-patient variability, necessitating therapeutic drug monitoring. Early post-transplant... |
PMC11859798 | core_pubmed_pmc | Pharmacokinetics of Snake Antivenom Following Intravenous and Intramuscular Administration in Envenomed Large Animal Model | Pharmacokinetics of Snake Antivenom Following Intravenous and Intramuscular Administration in Envenomed Large Animal Model Abstract Background : The parenteral administration of antivenoms is the mainstay in snakebite envenoming therapy. The standardized protocol does not exist, but it is agreed that the intravenous ( ... |
PMC12280724 | core_pubmed_pmc | From radiolabeling to receptor quantification: preclinical assessment of [ 99m Tc]Tc-carvedilol as a cardiac β-adrenoceptor probe | From radiolabeling to receptor quantification: preclinical assessment of [ 99m Tc]Tc-carvedilol as a cardiac β-adrenoceptor probe Abstract Abstract Introduction Accurate cardiac adrenoceptor assessment is crucial for managing cardiovascular diseases. This study introduces a novel radiotracer, technetium-99m-labeled car... |
PMC4195470 | core_pubmed_pmc | Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda | Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda Abstract Objectives Oral quinine is used for the treatment of uncomplicated malaria during pregnancy, but few pharmacokinetic data are available for this population. Previous studies have reported a subst... |
PMC11154823 | core_pubmed_pmc | PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives | PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives Abstract Abstract Leukemia is a heterogeneous group of life‐threatening malignant disorders of the hematopoietic system. Immunotherapy, radiotherapy, stem cell transplantation, targeted therapy, and chemotherapy are among the approve... |
PMC5946014 | core_pubmed_pmc | Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties | Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties Abstract Abstract Introduction Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase via a sequence-specific molecular protrusion (reactive ... |
PMC12115180 | core_pubmed_pmc | Development of Rifampicin Eye Drops for the Treatment of Exudative Age-Related Macular Degeneration | Development of Rifampicin Eye Drops for the Treatment of Exudative Age-Related Macular Degeneration Abstract Abstract Background/Objectives : Exudative age-related macular degeneration (AMD) is a disease of choroidal neovascularization that causes blindness. Current treatments to preserve vision in this prevalent and b... |
PMC10376356 | core_pubmed_pmc | Software- and TDM-Guided Dosing of Meropenem Promises High Rates of Target Attainment in Critically Ill Patients | Software- and TDM-Guided Dosing of Meropenem Promises High Rates of Target Attainment in Critically Ill Patients Abstract Various studies have reported insufficient beta-lactam concentrations in critically ill patients. The optimal dosing strategy for beta-lactams in critically ill patients, particularly in septic pati... |
PMC3748675 | core_pubmed_pmc | A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model | A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model Abstract Abstract Background: The square root of time (SqRT) model had been used to predict the uptake of volatile agents. Methods: We studied the rate of uptake of isoflurane in 10 patients using liquid iso... |
PMC3292705 | core_pubmed_pmc | Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions | Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions Abstract Abstract Mathematical models have substantially improved our ability to predict the response of a complex biological system to perturbation, but their use is typically limited by difficulties in s... |
PMC7719386 | core_pubmed_pmc | Pharmacokinetics, Pharmacodynamics, and Exposure‐Response of Lanadelumab for Hereditary Angioedema | Pharmacokinetics, Pharmacodynamics, and Exposure‐Response of Lanadelumab for Hereditary Angioedema Abstract Hereditary angioedema (HAE) with C1 inhibitor deficiency is a rare disorder characterized by unpredictable, potentially life‐threatening recurrent angioedema attacks. Lanadelumab is a fully human monoclonal antib... |
PMC10245548 | core_pubmed_pmc | Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement | Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement Abstract Background Antimicrobial resistance represents a major critical issue for the management of the critically ill patients hospitalized in the intensive care unit (ICU), since infec... |
PMC7825923 | core_pubmed_pmc | Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition | Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition Abstract In the current study, a structure-based virtual screening paradigm was used to screen a small molecular database against the Non-structural protein 15 (Nsp15) endoribonuclease of Severe Ac... |
PMC3836662 | core_pubmed_pmc | New Antimalarial Hits from Dacryodes edulis (Burseraceae) - Part I: Isolation, In Vitro Activity, In Silico “drug-likeness” and Pharmacokinetic Profiles | New Antimalarial Hits from Dacryodes edulis (Burseraceae) - Part I: Isolation, In Vitro Activity, In Silico “drug-likeness” and Pharmacokinetic Profiles Abstract Abstract The aims of the present study were to identify the compounds responsible for the anti-malarial activity of Dacryoedes edulis (Burseraceae) and to inv... |
PMC6214120 | core_pubmed_pmc | Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies | Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies Abstract Abstract Florfenicol (FFC) is a valuable synthetic fluorinated derivative of thiamphenicol widely used to treat infectious diseases in food animals. The aims of the stud... |
PMC9508025 | core_pubmed_pmc | Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice | Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice Abstract Abstract Chimeric antigen receptor (CAR) T cell therapies have revolutionized the treatment of hematologic malignancies and have potentials ... |
PMC6412839 | core_pubmed_pmc | Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract | Inhibition of Amyloid Beta Aggregation and Deposition of Cistanche tubulosa Aqueous Extract Abstract Cistanche tubulosa aqueous extract (CTE) is already used as a botanical prescription drug for treating dementia in China. Our previous studies reported that phenylethanoid glycosides of CTE have anti-Alzheimer’s disease... |
PMC10937897 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of aildenafil citrate tablets, a novel oral PDE5 inhibitor, in healthy Chinese volunteers after multiple-dose administration | Safety, tolerability, and pharmacokinetics of aildenafil citrate tablets, a novel oral PDE5 inhibitor, in healthy Chinese volunteers after multiple-dose administration Abstract Abstract Background Aildenafil citrate is a potent and selective inhibitor of cyclic guanosine monophosphate–specific phosphodiesterase type 5,... |
PMC12143985 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Axatilimab in Healthy Japanese Male Participants: Results from a Phase 1, Randomized, Double-Blind, Dose-Escalation Study | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Axatilimab in Healthy Japanese Male Participants: Results from a Phase 1, Randomized, Double-Blind, Dose-Escalation Study Abstract Background Axatilimab, an anti-colony-stimulating factor 1 receptor (CSF-1R) antibody, blocks colony-stimulating factor 1 (CS... |
PMC3258408 | core_pubmed_pmc | BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems | BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems Abstract Abstract We developed a detailed, whole-body physiologically based pharmacokinetic (PBPK) modeling tool for calculating the distribution of pharmaceutical agents in the various tissu... |
PMC12321116 | core_pubmed_pmc | Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation | Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation Abstract Abstract Purpose Corneal sensory innervation plays a crucial role in maintaining ocular surface integrity and immune homeostasis by regulati... |
PMC8100448 | core_pubmed_pmc | Competence Mining of Vancomycin (VAN) in the Management of Infections Due to Bacterial Strains With High VAN Minimum Inhibitory Concentrations (MICs): A Novel Dosing Strategy Based on Pharmacokinetic/Pharmacodynamic Modeling | Competence Mining of Vancomycin (VAN) in the Management of Infections Due to Bacterial Strains With High VAN Minimum Inhibitory Concentrations (MICs): A Novel Dosing Strategy Based on Pharmacokinetic/Pharmacodynamic Modeling Abstract The increasing emergence of bacterial strains with high VAN MICs (BS H – V AN– M ), su... |
PMC6704357 | core_pubmed_pmc | The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders | The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders Abstract Abstract KH176 is a potent intracellular reduction–oxidation‐modulating compound developed to treat mitochondrial disease. We studied tolerability, safety, pharmacokinetics, pharmacodynamics, and efficacy of twice da... |
PMC7294046 | core_pubmed_pmc | Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers | Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers Abstract Background Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism. Methods Two SMV carrier sy... |
PMC12800244 | core_pubmed_pmc | Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier | Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier Abstract The Blood–Brain Barrier (BBB) is a selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. Its function continues to ev... |
PMC12896365 | core_pubmed_pmc | Development of a Pregnancy‐Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin | Development of a Pregnancy‐Specific Physiologically Based Pharmacokinetics (PBPK) Model for Aspirin Abstract ABSTRACT Aspirin is one of the most commonly used medications in pregnancy, particularly for the prevention of hypertensive disorders. Despite aspirin's widespread use in pregnancy for preeclampsia prevention, i... |
PMC7224248 | core_pubmed_pmc | Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs? | Software Tools for Model-Informed Precision Dosing: How Well Do They Satisfy the Needs? Abstract Abstract Model-informed precision dosing (MIPD) software tools are used to optimize dosage regimens in individual patients, aiming to achieve drug exposure targets associated with desirable clinical outcomes. Over the last ... |
PMC2967470 | core_pubmed_pmc | Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition | Flavopiridol Pharmacogenetics: Clinical and Functional Evidence for the Role of SLCO1B1/OATP1B1 in Flavopiridol Disposition Abstract Background Flavopiridol is a cyclin-dependent kinase inhibitor in phase II clinical development for treatment of various forms of cancer. When administered with a pharmacokinetically (PK)... |
PMC8298633 | core_pubmed_pmc | Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations | Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations Abstract Abstract Cannabis is a complex mixture of hundreds of bioactive molecules. This provides the potential for pharmacological interactions between cannabis constituents, a phenomenon referred ... |
PMC8732812 | core_pubmed_pmc | Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4–5 Years with Attention-Deficit/Hyperactivity Disorder | Pharmacokinetics, Safety, and Tolerability of SHP465 Mixed Amphetamine Salts After Administration of Multiple Daily Doses in Children Aged 4–5 Years with Attention-Deficit/Hyperactivity Disorder Abstract Background Given the limited treatment options for younger children with attention-deficit/hyperactivity disorder (A... |
PMC7536268 | core_pubmed_pmc | Increased Antimicrobial Activity of Colistin in Combination With Gamithromycin Against Pasteurella multocida in a Neutropenic Murine Lung Infection Model | Increased Antimicrobial Activity of Colistin in Combination With Gamithromycin Against Pasteurella multocida in a Neutropenic Murine Lung Infection Model Abstract Abstract We investigate the antimicrobial activity of combined colistin and gamithromycin against nine Pasteurella multocida strains by testing in vitro susc... |
PMC6587269 | core_pubmed_pmc | Tamoxifen in horses: pharmacokinetics and safety study | Tamoxifen in horses: pharmacokinetics and safety study Abstract Abstract Background Tamoxifen (TAM), a selective modulator of estrogen receptors (SERMs) has been recently explored as a therapeutic option for the oral treatment of airway inflammation in the horse. The objective of this work was to establish pharmacokine... |
PMC5368958 | core_pubmed_pmc | GABA B receptor allosteric modulators exhibit pathway‐dependent and species‐selective activity | GABA B receptor allosteric modulators exhibit pathway‐dependent and species‐selective activity Abstract Abstract Positive modulation of the GABA B receptor (GABA B R) represents a potentially useful therapeutic approach for the treatment of nicotine addiction. The positive allosteric modulators (PAMs) of GABA B R GS397... |
PMC8742557 | core_pubmed_pmc | Pharmacokinetics of chloroquine and primaquine in healthy volunteers | Pharmacokinetics of chloroquine and primaquine in healthy volunteers Abstract Abstract Background Vivax malaria is a neglected disease. There is an irrefutable need for better treatments with higher acceptability and efficacy. The treatment efficacy is influenced by many factors, including bioavailability. Hence, a str... |
PMC9569971 | core_pubmed_pmc | New Oxazolo[5,4- d ]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research | New Oxazolo[5,4- d ]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research Abstract Cancer is a large group of diseases in which the rapid proliferation of abnormal cells generally leads to metastasis to surrounding tissues or more distant ones through the lymphat... |
PMC9346113 | core_pubmed_pmc | Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic | Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic Abstract Abstract Background BET inhibitors have been tested in several clinical trials where, despite encouraging preclinical results, substantial clinical benefit in monotherapy remains limited. This work illustrates the translat... |
PMC12711535 | core_pubmed_pmc | Delphi-based Spanish consensus on the use of long-acting growth hormone in pediatric growth hormone deficiency: recommendations from the ConverGHe Working Group | Delphi-based Spanish consensus on the use of long-acting growth hormone in pediatric growth hormone deficiency: recommendations from the ConverGHe Working Group Abstract Background Long-acting growth hormone (LAGH) formulations have emerged as an alternative to daily recombinant human growth hormone (rhGH) in pediatric... |
PMC3815146 | core_pubmed_pmc | Pilot study of 68 Ga-DOTA-F(ab′) 2 -trastuzumab in patients with breast cancer | Pilot study of 68 Ga-DOTA-F(ab′) 2 -trastuzumab in patients with breast cancer Abstract Abstract Objective 68 Ga-1,4,7,10-Tetraazacyclododecane- N , N ′, N ′′, N ′′′-tetraacetic acid (DOTA)-F(ab′) 2 -trastuzumab [ 68 Ga-DOTA-F(ab′) 2 -trastuzumab] has been developed at our institution as a positron imaging reagent for ... |
PMC3638632 | core_pubmed_pmc | Phase I Study of Ofatumumab, a Human Anti-CD20 Antibody, in Japanese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma | Phase I Study of Ofatumumab, a Human Anti-CD20 Antibody, in Japanese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Abstract Objectives Ofatumumab is a human IgG1κ monoclonal antibody that targets a membrane proximal epitope encompassing the small and large loops of CD2... |
PMC4291235 | core_pubmed_pmc | Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir | Pharmacokinetics and safety of rifabutin in young HIV-infected children receiving rifabutin and lopinavir/ritonavir Abstract Objectives Co-treatment of HIV and TB in young children is complicated by limited treatment options and complex drug–drug interactions. Rifabutin is an alternative to rifampicin for adults receiv... |
PMC12654646 | core_pubmed_pmc | Vancomycin Penetration in Brain Extracellular Fluid of Patients with Post-Surgical Central Nervous System Infections: An Exploratory Study | Vancomycin Penetration in Brain Extracellular Fluid of Patients with Post-Surgical Central Nervous System Infections: An Exploratory Study Abstract Background and Objectives : Post-surgical central nervous system (CNS) infections are severe complications associated with high morbidity and mortality. Vancomycin is a key... |
PMC8257283 | core_pubmed_pmc | Use of medicines for covid-19 treatment in patients with loss of kidney function: a narrative review | Use of medicines for covid-19 treatment in patients with loss of kidney function: a narrative review Abstract ABSTRACT Covid-19 has been identified as the cause of acute respiratory disease with interstitial and alveolar pneumonia, but it can affect several organs, such as kidneys, heart, blood, nervous system and dige... |
PMC8732887 | core_pubmed_pmc | Research and Education Needs for Complex Generics | Research and Education Needs for Complex Generics Abstract Abstract Complex generics are generic versions of drug products that generally have complex active ingredients, complex formulations, complex routes of delivery, complex dosage forms, are complex drug-device combination products, or have other characteristics t... |
PMC6072773 | core_pubmed_pmc | Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations | Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations Abstract A quantitative analysis of dose–response relationships is essential in preclinical and clinical drug development in order to optimize drug efficacy and safety, respectively. However, th... |
PMC6272486 | core_pubmed_pmc | Simultaneous Quantification of Diazepam and Dexamethasone in Plasma by High-Performance Liquid Chromatography with Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Comparison between Normoxic and Hypoxic Rats | Simultaneous Quantification of Diazepam and Dexamethasone in Plasma by High-Performance Liquid Chromatography with Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Comparison between Normoxic and Hypoxic Rats Abstract Abstract In order to investigate the pharmacokinetics of a combination of diazepam an... |
PMC6757423 | core_pubmed_pmc | Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine | Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine Abstract Abstract Background Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission. Artemisinin-based combination... |
PMC4827594 | core_pubmed_pmc | Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells | Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells Abstract Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs) is important because these cells are regarded as culprit of breast cancer relapse. Accomplishing this kind of strategy requires a specifi... |
PMC9790453 | core_pubmed_pmc | Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models | Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models Abstract Abstract Vocacapsaicin is a novel prodrug of trans‐capsaicin (trans‐8‐methyl‐ N ‐vanillyl‐6‐nonenamide) being developed as a nonopioid, long‐lasting, site‐specific tr... |
PMC11494827 | core_pubmed_pmc | Mechanistic pharmacokinetic–pharmacodynamic modeling and simulations of naloxone auto‐injector 10 mg reversal of opioid‐induced respiratory depression | Mechanistic pharmacokinetic–pharmacodynamic modeling and simulations of naloxone auto‐injector 10 mg reversal of opioid‐induced respiratory depression Abstract Abstract The purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid‐induced respiratory depres... |
PMC8656167 | core_pubmed_pmc | Preliminary Pharmacogenomic-Based Predictive Models of Tamoxifen Response in Hormone-dependent Chilean Breast Cancer Patients | Preliminary Pharmacogenomic-Based Predictive Models of Tamoxifen Response in Hormone-dependent Chilean Breast Cancer Patients Abstract Tamoxifen (TAM), a selective oestrogen receptor modulator, is one of the most used treatments in oestrogen receptor-positive (ER+) early and metastatic breast cancer (BC) patients. The ... |
PMC10772343 | core_pubmed_pmc | Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial | Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial Abstract Summary Macrophage Clever-1 contributes to impaired antigen presentation and suppression of anti-tumor immunity. This first-in-human trial investigates the safety and tolerability o... |
PMC9330032 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review | Pharmacokinetic/Pharmacodynamic Modeling and Application in Antibacterial and Antifungal Pharmacotherapy: A Narrative Review Abstract Pharmacokinetics and pharmacodynamics are areas in pharmacology related to different themes in the pharmaceutical sciences, including therapeutic drug monitoring and different stages of ... |
PMC4629597 | core_pubmed_pmc | Fosfomycin: Uses and potentialities in veterinary medicine | Fosfomycin: Uses and potentialities in veterinary medicine Abstract Fosfomycin (FOS) is a natural bactericidal broad-spectrum antibiotic which acts on proliferating bacteria by inhibiting cell wall and early murein/peptidoglycan synthesis. Bactericidal activity is evident against Gram positive and Gram negative bacteri... |
PMC5464911 | core_pubmed_pmc | SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains | SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains Abstract Inhibition of oncogenic transcriptional programs is a promising therapeutic strategy. A substituted tricyclic benzimidazole, SEL120-34A, is a novel inhibitor of Cyclin-... |
PMC6780046 | core_pubmed_pmc | Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection | Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection Abstract Background and Purpose Severe influenza A virus (IAV) infections are associated with damaging hyperinflammation that can be fatal. There is an urgent need to identify new therapeutic agents to ... |
PMC5008646 | core_pubmed_pmc | The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate | The influence of different long-circulating materials on the pharmacokinetics of liposomal vincristine sulfate Abstract Abstract Purpose This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, po... |
PMC10269625 | core_pubmed_pmc | Comparative Activities of Novel Therapeutic Agents against Molecularly Characterized Clinical Carbapenem-Resistant Enterobacterales Isolates | Comparative Activities of Novel Therapeutic Agents against Molecularly Characterized Clinical Carbapenem-Resistant Enterobacterales Isolates Abstract ABSTRACT Limited treatment options exist for the treatment of carbapenem-resistant Enterobacterales (CRE) bacteria. Fortunately, there are several recently approved antib... |
PMC7903657 | core_pubmed_pmc | Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy | Acute pharmacodynamic effects of pimobendan in client-owned cats with subclinical hypertrophic cardiomyopathy Abstract Background Prior studies have suggested that pimobendan is associated with several positive effects in cats, including improved survival in cats with congestive heart failure and improved left atrial f... |
PMC4199987 | core_pubmed_pmc | Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers | Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers Abstract Purpose Evogliptin (DA-1229) is a novel, potent, and selective dipeptidyl peptidase IV (DPP-IV) inhibitor in clinical development for the treatment of type 2 diabetes me... |
PMC4034564 | core_pubmed_pmc | Defining antibiotic resistance-towards international harmonization | Defining antibiotic resistance-towards international harmonization Abstract Abstract Antimicrobial susceptibility testing with phenotypic methods requires breakpoints, i.e. a minimum inhibitory concentration (MIC) categorizing micro-organisms into susceptible, intermediately susceptible, and resistant for the relevant ... |
PMC8505636 | core_pubmed_pmc | Metformin hydrochloride entrapment in sorbitan monostearate for intestinal permeability enhancement and pharmacodynamics | Metformin hydrochloride entrapment in sorbitan monostearate for intestinal permeability enhancement and pharmacodynamics Abstract Penetration enhancement of metformin hydrochloride via its molecular dispersion in sorbitan monostearate microparticles is reported. This represents basic philosophy to maximize its entrapme... |
PMC12908354 | core_pubmed_pmc | Engineered extracellular vesicles displaying bi-specific T-cell engagers for targeted therapy of B-cell malignancies | Engineered extracellular vesicles displaying bi-specific T-cell engagers for targeted therapy of B-cell malignancies Abstract Despite the clinical success of T cell-based immunotherapies such as CAR-T cells and bispecific T cell engagers (BiTEs), therapeutic resistance and immune suppression remain significant barriers... |
PMC12934994 | core_pubmed_pmc | Pediatric Oral Cavity Physiologically Based Pharmacokinetic Model to Predict Pharmacokinetics of Mucoadhesive Atropine Gel to Treat Sialorrhea | Pediatric Oral Cavity Physiologically Based Pharmacokinetic Model to Predict Pharmacokinetics of Mucoadhesive Atropine Gel to Treat Sialorrhea Abstract Abstract Sialorrhea is a debilitating condition that significantly impairs quality of life in children with neurodevelopmental disorders, including cerebral palsy and n... |
PMC8383318 | core_pubmed_pmc | Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks | Preclinical Pharmacokinetics, Tissue Distribution, and Primary Safety Evaluation of Indo5, a Novel Selective Inhibitor of c-Met and Trks Abstract The compound [3-(1H-benzimidazol-2-methylene)-5-(2-methylphenylaminosulfo)-2-indolone], known as Indo5, is a novel selective inhibitor of c-Met and Trks, and it is a promisin... |
PMC4695035 | core_pubmed_pmc | Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer | Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer Abstract Disseminated triple negative breast cancer (TNBC) is an incurable disease with limited therapeutic options beyond chemotherapy. Therefore, identification of druggable vulnerabilities is an important aim. Protein ki... |
PMC12605714 | core_pubmed_pmc | Clinical and translational study of ivosidenib plus nivolumab in advanced solid tumors harboring IDH1 mutations | Clinical and translational study of ivosidenib plus nivolumab in advanced solid tumors harboring IDH1 mutations Abstract Abstract Background Cancers that do not respond to immunotherapy typically harbor a non-T cell-inflamed tumor microenvironment (TME), characterized by the absence of type I/II interferon signaling an... |
PMC6320780 | core_pubmed_pmc | Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient | Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient Abstract Abstract Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets... |
PMC9944146 | core_pubmed_pmc | Potential Drug–Drug Interactions Among Hospitalised Elderly Patients in Northern Sri Lanka, A Lower Middle-Income Country: A Retrospective Analysis | Potential Drug–Drug Interactions Among Hospitalised Elderly Patients in Northern Sri Lanka, A Lower Middle-Income Country: A Retrospective Analysis Abstract Abstract Background and Objectives Elderly individuals are more vulnerable to potential drug–drug interactions (pDDIs) as age-related physiological changes, polyph... |
PMC12525253 | core_pubmed_pmc | Navigating the Central Nervous System (CNS): A Pharmacokinetic Approach to the Treatment of CNS Tumors, Glioblastoma Multiforme (GBM), in Particular | Navigating the Central Nervous System (CNS): A Pharmacokinetic Approach to the Treatment of CNS Tumors, Glioblastoma Multiforme (GBM), in Particular Abstract Tumors of the central nervous system (CNS) represent a unique therapeutic challenge due to the complexity of the CNS and the protective role of the blood–brain ba... |
PMC6930855 | core_pubmed_pmc | Predicting Paclitaxel Disposition in Humans With Whole‐Body Physiologically‐Based Pharmacokinetic Modeling | Predicting Paclitaxel Disposition in Humans With Whole‐Body Physiologically‐Based Pharmacokinetic Modeling Abstract Abstract Paclitaxel is a commonly used drug in the treatment of multiple solid tumors, including cancers of the breast, lung, and ovaries. Despite the established exposure–pharmacodynamic relationships fo... |
PMC9618397 | core_pubmed_pmc | Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells | Moringa oleifera leaf extract induces osteogenic-like differentiation of human osteosarcoma SaOS2 cells Abstract Introduction Moringa oleifera is known as a ‘natural nutrition of the tropics’ because it provides vital nutritional supplements and a variety of pharmacological benefits. The focus of this study was to eluc... |
PMC11530514 | core_pubmed_pmc | Introducing the Biosimilar Paradigm to Neurology: The Totality of Evidence for the First Biosimilar Natalizumab | Introducing the Biosimilar Paradigm to Neurology: The Totality of Evidence for the First Biosimilar Natalizumab Abstract A biosimilar medicine is a successor to a reference (‘originator’/’original-brand’) biologic medicine brought to market once the patent and exclusive marketing rights for the reference have expired. ... |
PMC12527135 | core_pubmed_pmc | In vivo assessment of buparvaquone resistant Theileria annulata populations: genetic structure, transmission dynamics, drug susceptibility and pharmacokinetics | In vivo assessment of buparvaquone resistant Theileria annulata populations: genetic structure, transmission dynamics, drug susceptibility and pharmacokinetics Abstract Tropical theileriosis, caused by the protozoan parasite Theileria annulata and transmitted by several species of ixodid ticks of the genus Hyalomma, is... |
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