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PMC9774927 | core_pubmed_pmc | The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults | The Blood–Brain Barrier and Pharmacokinetic/Pharmacodynamic Optimization of Antibiotics for the Treatment of Central Nervous System Infections in Adults Abstract Abstract Bacterial central nervous system (CNS) infections are serious and carry significant morbidity and mortality. They encompass many syndromes, the most ... |
PMC8380870 | core_pubmed_pmc | Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2 | Accelerated first-in-human clinical trial of EIDD-2801/MK-4482 (molnupiravir), a ribonucleoside analog with potent antiviral activity against SARS-CoV-2 Abstract Abstract A recently published article described the safety, tolerability, and pharmacokinetic profile of molnupiravir (Painter et al. 2021), a novel antiviral... |
PMC3165084 | core_pubmed_pmc | A Phase 1 Trial Dose Escalation Study of Tipifarnib on a Week-On, Week-Off Schedule in Relapsed, Refractory or High-Risk Myeloid Leukemia | A Phase 1 Trial Dose Escalation Study of Tipifarnib on a Week-On, Week-Off Schedule in Relapsed, Refractory or High-Risk Myeloid Leukemia Abstract Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. We report the results of a phase 1 dose escalation stud... |
PMC8167502 | core_pubmed_pmc | The effect of morning versus evening administration of empagliflozin on its pharmacokinetics and pharmacodynamics characteristics in healthy adults: a two-way crossover, non-randomised trial | The effect of morning versus evening administration of empagliflozin on its pharmacokinetics and pharmacodynamics characteristics in healthy adults: a two-way crossover, non-randomised trial Abstract Background : Empagliflozin is an SGLT2 inhibitor approved for use in patients with diabetes mellitus type 2 (DMT2) with ... |
PMC12582837 | core_pubmed_pmc | Mechanism, research progress and warning of the effects of acupuncture at Zusanli point (ST36) on pharmacokinetics: A review | Mechanism, research progress and warning of the effects of acupuncture at Zusanli point (ST36) on pharmacokinetics: A review Abstract In traditional Chinese medicine, acupuncture is considered free of harmful side effects when properly performed. Pharmacokinetics provides a valuable approach to explore how acupuncture ... |
PMC4875984 | core_pubmed_pmc | Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer | Curcumin and Resveratrol as Promising Natural Remedies with Nanomedicine Approach for the Effective Treatment of Triple Negative Breast Cancer Abstract Researchers have made considerable progress in last few decades in understanding mechanisms underlying pathogenesis of breast cancer, its phenotypes, its molecular and ... |
PMC12535240 | core_pubmed_pmc | A Systematic Review of Population Pharmacokinetics, Safety, and Factors Influencing Trough Concentrations of Voriconazole in Asian Patients with Liver Dysfunction | A Systematic Review of Population Pharmacokinetics, Safety, and Factors Influencing Trough Concentrations of Voriconazole in Asian Patients with Liver Dysfunction Abstract Abstract Objective This study systematically reviews recent research on voriconazole (VRC) use in Asian patients with liver dysfunction to provide a... |
PMC7419427 | core_pubmed_pmc | Murine Thigh Microdialysis to Evaluate the Pharmacokinetic/Pharmacodynamic Integration of Cefquinome Against Actinobacillus pleuropneumoniae | Murine Thigh Microdialysis to Evaluate the Pharmacokinetic/Pharmacodynamic Integration of Cefquinome Against Actinobacillus pleuropneumoniae Abstract This study aimed to explore the application of microdialysis in pharmacokinetic (PK)/pharmacodynamic (PD) integration of cefquinome against Actinobacillus pleuropneumonia... |
PMC10381519 | core_pubmed_pmc | New Perspective for Drug–Drug Interaction in Perioperative Period | New Perspective for Drug–Drug Interaction in Perioperative Period Abstract In this review, we aim to discuss current information on drug interactions in the perioperative period. During this period, patients receive several drugs that may interact with each other and affect the efficacy and safety of the treatment. The... |
PMC12180079 | core_pubmed_pmc | Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1 | Insights Into Atorvastatin Pharmacokinetics in Rats Reveal Regulation of CYP3A1 by Humanization of SLCO2B1 Abstract ABSTRACT The organic anion transporting polypeptide (OATP) 2B1 is expressed in pharmacokinetically relevant organs such as the liver, the kidney, and the small intestine and it is known to transport a bro... |
PMC11481060 | core_pubmed_pmc | Exploring the clinical factors affecting lithium dose and plasma level and the effect of brand | Exploring the clinical factors affecting lithium dose and plasma level and the effect of brand Abstract Abstract Background: Optimal use of lithium involves adjustment of the dose, to keep the plasma level within the narrow, recommended range. Brand-specific prescribing has long been considered critical to achieving th... |
PMC10649793 | core_pubmed_pmc | Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice | Local and distant response to intratumoral immunotherapy assessed by immunoPET in mice Abstract Abstract Background Despite the promising efficacy of immune checkpoint blockers (ICB), tumor resistance and immune-related adverse events hinder their success in cancer treatment. To address these challenges, intratumoral d... |
PMC4983396 | core_pubmed_pmc | Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies | Emerging Technologies and Generic Assays for the Detection of Anti-Drug Antibodies Abstract Abstract Anti-drug antibodies induced by biologic therapeutics often impact drug pharmacokinetics, pharmacodynamics response, clinical efficacy, and patient safety. It is critical to assess the immunogenicity risk of potential b... |
PMC3258012 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus | Pharmacokinetics and pharmacodynamics of insulin analogs in special populations with type 2 diabetes mellitus Abstract Abstract Introduction The goal of insulin therapy in patients with either type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) is to match as closely as possible normal physiologic insuli... |
PMC10190255 | core_pubmed_pmc | Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy | Systematic Evaluation of Pharmacokinetic Models for Model-Informed Precision Dosing of Meropenem in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Abstract ABSTRACT The altered pharmacokinetics of renally cleared drugs such as meropenem in critically ill patients receiving continuous renal repl... |
PMC11561661 | core_pubmed_pmc | Pharmacokinetics of PP353 , a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study | Pharmacokinetics of PP353 , a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study Abstract Abstract Background Bacterial infection of the intervertebral disc is difficult to treat becau... |
PMC4285808 | core_pubmed_pmc | Pharmacokinetic overview of ethinyl estradiol dose and bioavailability using two transdermal contraceptive systems and a standard combined oral contraceptive | Pharmacokinetic overview of ethinyl estradiol dose and bioavailability using two transdermal contraceptive systems and a standard combined oral contraceptive Abstract Abstract Objective: To determine the relative bioavailability of ethinyl estradiol (EE) and gestodene (GSD) after application of a novel transdermal cont... |
PMC10875779 | core_pubmed_pmc | Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies | Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies Abstract Background Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in t... |
PMC12436539 | core_pubmed_pmc | Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients | Serum Concentration of Apixaban in Relation to Renal Function in Older Hospitalized Patients Abstract Abstract Background and Objective Apixaban is the most prescribed direct-acting oral anticoagulant drug. According to its product information, clearance is only partially renal. However, little is known about the impac... |
PMC11993231 | core_pubmed_pmc | Pharmacokinetics and Side Effects of Δ 9 -Tetrahydrocannabinol and Cannabidiol in Patients with Different Stages of CKD | Pharmacokinetics and Side Effects of Δ 9 -Tetrahydrocannabinol and Cannabidiol in Patients with Different Stages of CKD Abstract Introduction Chronic kidney disease (CKD) affects approximately 10% of the global population and is associated with a large symptom burden. Medicinal cannabis is advised against in patients w... |
PMC10261012 | core_pubmed_pmc | Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer | Phase 1b trial of anti-EGFR antibody JMT101 and Osimertinib in EGFR exon 20 insertion-positive non-small-cell lung cancer Abstract EGFR exon 20 insertion (20ins)-positive non-small-cell lung cancer (NSCLC) is an uncommon disease with limited therapeutic options and dismal prognosis. Here we report the activity, tolerab... |
PMC4006077 | core_pubmed_pmc | A missed opportunity – consequences of unknown levetiracepam pharmacokinetics in a peritoneal dialysis patient | A missed opportunity – consequences of unknown levetiracepam pharmacokinetics in a peritoneal dialysis patient Abstract Background Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 6... |
PMC11116716 | core_pubmed_pmc | Population pharmacokinetics, dosing optimization and clinical outcomes of biapenem in patients with sepsis | Population pharmacokinetics, dosing optimization and clinical outcomes of biapenem in patients with sepsis Abstract Introduction: Biapenem is a carbapenem antibiotic widely used in Asia, can be used for the treatment of adults and children with infections due to susceptible bacteria. Although biapenem is utilized in th... |
PMC11930543 | core_pubmed_pmc | Population Pharmacokinetics and Pharmacodynamics of Sitafloxacin in Plasma and Alveolar Epithelial Lining Fluid of Critically Ill Thai Patients With Pneumonia | Population Pharmacokinetics and Pharmacodynamics of Sitafloxacin in Plasma and Alveolar Epithelial Lining Fluid of Critically Ill Thai Patients With Pneumonia Abstract ABSTRACT Sitafloxacin is one of the oral respiratory quinolones for the treatment of community‐acquired pneumonia. The pharmacokinetic (PK) changes of s... |
PMC7911130 | core_pubmed_pmc | The Protein-Binding Behavior of Platinum Anticancer Drugs in Blood Revealed by Mass Spectrometry | The Protein-Binding Behavior of Platinum Anticancer Drugs in Blood Revealed by Mass Spectrometry Abstract Abstract Cisplatin and its analogues are widely used as chemotherapeutic agents in clinical practice. After being intravenously administrated, a substantial amount of platinum will bind with proteins in the blood. ... |
PMC6306724 | core_pubmed_pmc | Pharmacogenomic Profiling of ADME Gene Variants: Current Challenges and Validation Perspectives | Pharmacogenomic Profiling of ADME Gene Variants: Current Challenges and Validation Perspectives Abstract Abstract In the past decades, many efforts have been made to individualize medical treatments, taking into account molecular profiles and the individual genetic background. The development of molecularly targeted dr... |
PMC12642743 | core_pubmed_pmc | First-In-Human Trial of Encapsulated Cell-Based Protein Producers for Localized IL-2 in Patients with High-Grade Serous Ovarian Carcinoma | First-In-Human Trial of Encapsulated Cell-Based Protein Producers for Localized IL-2 in Patients with High-Grade Serous Ovarian Carcinoma Abstract Abstract Background: Platinum-resistant high-grade serous ovarian carcinomas (HGSOC) are associated with poor therapeutic outcomes. While HGSOC frequently metastasizes to th... |
PMC9557049 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against Clostridium perfringens in an intestinal infection model | Pharmacokinetics and pharmacodynamics of isopropoxy benzene guanidine against Clostridium perfringens in an intestinal infection model Abstract Abstract This study aimed to evaluate the antibacterial activity of isopropoxy benzene guanidine (IBG) against C. perfringens based on pharmacokinetics/pharmacodynamics (PK/PD)... |
PMC10420276 | core_pubmed_pmc | Prescribed Versus Taken Polypharmacy and Drug–Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study | Prescribed Versus Taken Polypharmacy and Drug–Drug Interactions in Older Cardiovascular Patients during the COVID-19 Pandemic: Observational Cross-Sectional Analytical Study Abstract The study aimed to assess clinical pharmacology patterns of prescribed and taken medications in older cardiovascular patients using elect... |
PMC8082150 | core_pubmed_pmc | Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis | Minireview on Novel Anti-infectious Treatment Options and Optimized Drug Regimens for Sepsis Abstract Abstract Sepsis, a life-threatening organ dysfunction caused by a dysregulated response to infection is a major public health concern, as it is a leading cause of mortality and critical illness worldwide. Antibiotics a... |
PMC8956739 | core_pubmed_pmc | A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens | A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens Abstract Abstract The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are often the only therapeutic optio... |
PMC6019484 | core_pubmed_pmc | Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers | Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers Abstract Abstract Background: Vicagrel is a novel anti-platelet drug and hydrolyzed to the same intermediate as clopidogrel via esterase, instead of CYP2C19. Here we report the first cl... |
PMC10066622 | core_pubmed_pmc | Assessing the Knowledge and Perceptions of Medical Students After Using Kahoot! in Pharmacology Practical Sessions at King Abdulaziz University, Jeddah | Assessing the Knowledge and Perceptions of Medical Students After Using Kahoot! in Pharmacology Practical Sessions at King Abdulaziz University, Jeddah Abstract Objective Game-based e-learning (GbEl) has been shown to motivate students significantly, encourage learning, and improve academic performance. Kahoot! is one ... |
PMC6591615 | core_pubmed_pmc | Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection | Fluoroquinolones in Drug-Resistant Tuberculosis: Culture Conversion and Pharmacokinetic/Pharmacodynamic Target Attainment To Guide Dose Selection Abstract Fluoroquinolones are group A drugs in tuberculosis guidelines. We aim to compare the culture conversion between new-generation (levofloxacin and moxifloxacin) and ol... |
PMC11551477 | core_pubmed_pmc | An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction | An integrated population pharmacokinetic model of febuxostat in pediatric patients with hyperuricemia including gout and adult population of healthy subjects and patients with renal dysfunction Abstract Abstract The study objective was to validate febuxostat dosage and administration in pediatric patients with hyperuri... |
PMC8186476 | core_pubmed_pmc | Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infection | Pharmacogenomic considerations for repurposing of dexamethasone as a potential drug against SARS-CoV-2 infection Abstract Abstract Immunomodulatory and analgesic effects of dexamethasone are clinically well established, and this synthetic corticosteroid acts as an agonist of glucocorticoid receptors. Early results of t... |
PMC7477386 | core_pubmed_pmc | Pharmacodynamic Properties of Subcutaneous Immunoglobulin in Myasthenia Gravis: Sub-analyses From an Open-Label Trial | Pharmacodynamic Properties of Subcutaneous Immunoglobulin in Myasthenia Gravis: Sub-analyses From an Open-Label Trial Abstract Abstract Background: We previously reported an open-label prospective trial of subcutaneous immunoglobulin (SCIg) in mild to moderate exacerbations of myasthenia gravis (MG). The effective dose... |
PMC10590806 | core_pubmed_pmc | Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach | Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach Abstract Background Helicobacter pylori ( H. pylori ) is a persistent bacterial inhabitant in the stomachs of approximately half the global populace. This bacterium is d... |
PMC3902632 | core_pubmed_pmc | Therapeutic drug monitoring for imatinib: Current status and Indian experience | Therapeutic drug monitoring for imatinib: Current status and Indian experience Abstract Abstract Imatinib is the current gold standard for treatment of chronic myeloid leukemia (CML). Recent pharmacokinetic studies have shown considerable variability in trough concentrations of imatinib due to variations in its metabol... |
PMC7935830 | core_pubmed_pmc | Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model | Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model Abstract Abstract Purpose A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model bui... |
PMC6402530 | core_pubmed_pmc | Mathematical modeling and computational prediction of cancer drug resistance | Mathematical modeling and computational prediction of cancer drug resistance Abstract Abstract Diverse forms of resistance to anticancer drugs can lead to the failure of chemotherapy. Drug resistance is one of the most intractable issues for successfully treating cancer in current clinical practice. Effective clinical ... |
PMC10537526 | core_pubmed_pmc | Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol | Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol Abstract Abstract Following the contraindication of codeine use in children, increasing use of tramadol has been observed in pain management protocols. However, tramadol’s pharmacokinetics (PK) and pharmacodynamics are influenced by cyt... |
PMC12587609 | core_pubmed_pmc | Deconvoluting drug interactions using M. tuberculosis physiologic processes: transcriptional disaggregation of the BPaL regimen in vivo | Deconvoluting drug interactions using M. tuberculosis physiologic processes: transcriptional disaggregation of the BPaL regimen in vivo Abstract ABSTRACT A key challenge in preclinical tuberculosis drug development is identifying optimal antibiotic combinations. Drug interactions are complex because one drug may affect... |
PMC9365383 | core_pubmed_pmc | Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab | Model-Based Characterization of the Bidirectional Interaction Between Pharmacokinetics and Tumor Growth Dynamics in Patients with Metastatic Merkel Cell Carcinoma Treated with Avelumab Abstract Abstract Purpose: Empirical time-varying clearance models have been reported for several immune checkpoint inhibitors, includi... |
PMC12808451 | core_pubmed_pmc | Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates | Neoantigen immune responses in healthy volunteers: insights from multiple integrated keyhole limpet hemocyanin challenge studies on repeated immunization and response covariates Abstract Introduction Investigational immunomodulatory drugs are often initially investigated in healthy volunteers, which lack drug-target en... |
PMC12420565 | core_pubmed_pmc | Semaglutide - properties, action and chromatographic analysis | Semaglutide - properties, action and chromatographic analysis Abstract Objectives This review assessed the selected information on semaglutide’s activity, its potential for the treatment of various diseases, and its pharmacokinetics. It is intended as a guide for future research. Chromatographic procedures used for the... |
PMC8470483 | core_pubmed_pmc | Bidirectional Influences of Cranberry on the Pharmacokinetics and Pharmacodynamics of Warfarin with Mechanism Elucidation | Bidirectional Influences of Cranberry on the Pharmacokinetics and Pharmacodynamics of Warfarin with Mechanism Elucidation Abstract Cranberry is a dietary supplement popularly used for the prophylaxis of urinary tract infection. Interestingly, cranberry–warfarin interactions in clinical reports have shown bidirectional ... |
PMC4784825 | core_pubmed_pmc | Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery | Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery Abstract Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic chemotherapy combined with radiation, but there is a clear need for improvement of ... |
PMC8772788 | core_pubmed_pmc | Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model | Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model Abstract We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas aeruginosa i... |
PMC10317528 | core_pubmed_pmc | Microbiologic Cure with a Simplified Dosage of Intravenous Colistin in Adults: A Retrospective Cohort Study | Microbiologic Cure with a Simplified Dosage of Intravenous Colistin in Adults: A Retrospective Cohort Study Abstract Abstract Purpose Colistin’s FDA weight-based dosing (WBD) and frequency are both expressed in a broad range. Therefore, a simplified fixed-dose regimen (SFDR) of intravenous colistin based on three body-... |
PMC6466860 | core_pubmed_pmc | A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia | A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled Polymyxins for Gram-Negative Pneumonia Abstract Despite advancements in therapy, pneumonia remains the leading cause of death due to infectious diseases. Novel treatment strategies are desperately needed to optimize the antimicrobial therapy of patie... |
PMC6390583 | core_pubmed_pmc | In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) | In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) Abstract Abstract Background Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in t... |
PMC9381887 | core_pubmed_pmc | Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases | Multi‐model averaging improves the performance of model‐guided infliximab dosing in patients with inflammatory bowel diseases Abstract Abstract Infliximab dosage de‐escalation without prior knowledge of drug concentrations may put patients at risk for underexposure and trigger the loss of response. A single‐model appro... |
PMC9834004 | core_pubmed_pmc | Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model | Biodistribution and pharmacokinetic evaluation of Korean Red Ginseng components using radioisotopes in a rat model Abstract Abstract Background Although many studies have evaluated the efficacy and pharmacokinetics of Korean Red Ginseng (KRG) components (Rg1, Rb1, Rg3, Rd, etc.), few have examined the in vivo pharmacok... |
PMC4989500 | core_pubmed_pmc | Determination of diclofenac concentrations in human plasma using a sensitive gas chromatography mass spectrometry method | Determination of diclofenac concentrations in human plasma using a sensitive gas chromatography mass spectrometry method Abstract Abstract Background A gas chromatography mass spectrometry (GCMS) method for the determination of diclofenac in human plasma has been developed and validated. Results This method utilizes he... |
PMC7946665 | core_pubmed_pmc | Concentration–QTc analysis of quizartinib in patients with relapsed/refractory acute myeloid leukemia | Concentration–QTc analysis of quizartinib in patients with relapsed/refractory acute myeloid leukemia Abstract Purpose This analysis evaluated the relationship between concentrations of quizartinib and its active metabolite AC886 and QT interval corrected using Fridericia’s formula (QTcF) in patients with relapsed/refr... |
PMC12104385 | core_pubmed_pmc | Corchorus olitorius exhibits antiproliferative potential supported by metabolic profiling and integrative biological analyses | Corchorus olitorius exhibits antiproliferative potential supported by metabolic profiling and integrative biological analyses Abstract Abstract Herbal nutraceuticals could be employed as alternative or complementary routes for alleviating cancer. Corchorus olitorius (Malvaceae) was employed traditionally in the managem... |
PMC5910468 | core_pubmed_pmc | A Randomized Trial Investigating the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Semaglutide Once-Weekly in Healthy Male Japanese and Caucasian Subjects | A Randomized Trial Investigating the Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Semaglutide Once-Weekly in Healthy Male Japanese and Caucasian Subjects Abstract Abstract Introduction Semaglutide is a glucagon-like peptide-1 analogue for once-weekly subcutaneous treatment of type 2 diabetes. This tri... |
PMC5553100 | core_pubmed_pmc | Phase I study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus Fortecortin dexamethasone tablets | Phase I study evaluating the safety, tolerability and pharmacokinetics of a novel oral dissolvable film containing dexamethasone versus Fortecortin dexamethasone tablets Abstract ABSTRACT Introduction : Systemic corticosteroids are anti-inflammatory agents with dexamethasone among the most potent in the class. Within (... |
PMC7856757 | core_pubmed_pmc | Temporarily switching from oral to intravenous selexipag in patients with pulmonary arterial hypertension: safety, tolerability, and pharmacokinetic results from an open-label, phase III study | Temporarily switching from oral to intravenous selexipag in patients with pulmonary arterial hypertension: safety, tolerability, and pharmacokinetic results from an open-label, phase III study Abstract Background The oral IP receptor agonist selexipag is approved for the long-term treatment of pulmonary arterial hypert... |
PMC3402269 | core_pubmed_pmc | Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes | Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes Abstract Abstract OBJECTIVE Metabolic activation of the innate immune system governed by interleukin (IL)-1β contributes to β-cell failure in type 2 diabetes. Gevokizumab is a novel, human-engineered monoclonal anti–IL-1β antibody. We evalua... |
PMC9344630 | core_pubmed_pmc | Continuous infusion versus intermittent infusion of vancomycin in critically ill patients undergoing continuous venovenous hemofiltration: a prospective interventional study | Continuous infusion versus intermittent infusion of vancomycin in critically ill patients undergoing continuous venovenous hemofiltration: a prospective interventional study Abstract Background A prospective interventional study comparing outcomes in critically ill patients receiving intermittent infusion (II) or conti... |
PMC12098381 | core_pubmed_pmc | Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients | Correlation analysis of pharmacokinetic parameters of docetaxel AUC and adverse reactions in breast cancer patients Abstract Abstract Background Docetaxel is commonly used in breast cancer chemotherapy. The previous drug dose is generally calculated based on body surface area (BSA). However, the metabolism varies great... |
PMC11933637 | core_pubmed_pmc | Are All Pharmacokinetic Equations Created Equal? A Comparative Analysis of Trapezoidal and Non-Trapezoidal Methods for Estimating Day 1 Area Under the Curve in Adult Hospitalized Patients with Staphylococcus aureus Bacteremia | Are All Pharmacokinetic Equations Created Equal? A Comparative Analysis of Trapezoidal and Non-Trapezoidal Methods for Estimating Day 1 Area Under the Curve in Adult Hospitalized Patients with Staphylococcus aureus Bacteremia Abstract Abstract Introduction This study compared the calculated vancomycin area under the cu... |
PMC12783228 | core_pubmed_pmc | Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum | Development of a Semi-Mechanistic Population Pharmacokinetic Model for Predicting Tenofovir Disoproxil Fumarate and Tenofovir Alafenamide Exposure in Plasma and Cellular Matrices During Pregnancy and Postpartum Abstract Abstract Background and Objective Tenofovir (TFV)-based regimens are backbones of both HIV treatment... |
PMC7003773 | core_pubmed_pmc | Dalbavancin Population Pharmacokinetic Modeling and Target Attainment Analysis | Dalbavancin Population Pharmacokinetic Modeling and Target Attainment Analysis Abstract Abstract Dalbavancin is indicated for the treatment of acute bacterial skin and skin structure infections caused by susceptible gram‐positive microorganisms. This analysis represents the update of the population pharmacokinetics (po... |
PMC10223637 | core_pubmed_pmc | Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project | Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project Abstract Abstract Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of materna... |
PMC12425505 | core_pubmed_pmc | Peptide-based drug as atherosclerosis multitarget therapy from Lytechinus variegatus spine: An in silico study | Peptide-based drug as atherosclerosis multitarget therapy from Lytechinus variegatus spine: An in silico study Abstract Abstract Atherosclerosis is a leading cardiovascular disease characterized by the buildup of plaques within arterial walls. The aim of this study was to investigate the potential of peptides derived f... |
PMC10376599 | core_pubmed_pmc | Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients | Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Obese Patients Abstract Obesity is a significant global public health concern that is associated with an elevated risk of comorbidities as well as severe postoperative and nosocomial infections. The treatment of infections in critically ill obese patients ... |
PMC10870500 | core_pubmed_pmc | Impact of model-informed precision dosing in adults receiving vancomycin via continuous infusion: a randomized, controlled clinical trial | Impact of model-informed precision dosing in adults receiving vancomycin via continuous infusion: a randomized, controlled clinical trial Abstract Background Vancomycin is a commonly prescribed antibiotic to treat gram-positive infections. The efficacy of vancomycin is known to be directly related to the pharmacokineti... |
PMC12939220 | core_pubmed_pmc | In Silico Molecular Docking and Pharmacokinetic Evaluation of Cannabinoid Derivatives as Multi-Target Inhibitors for EGFR, VEGFR-1, and VEGFR-2 Proteins | In Silico Molecular Docking and Pharmacokinetic Evaluation of Cannabinoid Derivatives as Multi-Target Inhibitors for EGFR, VEGFR-1, and VEGFR-2 Proteins Abstract Abstract Cancer therapy development increasingly focuses on multi-target approaches to inhibit key proteins involved in tumor growth and angiogenesis. This st... |
PMC11529615 | core_pubmed_pmc | Safety and efficacy of personalised versus standard dosing of linezolid in patients with sepsis (SePkLin): a pragmatic, multicentre, randomised, controlled and superiority clinical trial protocol | Safety and efficacy of personalised versus standard dosing of linezolid in patients with sepsis (SePkLin): a pragmatic, multicentre, randomised, controlled and superiority clinical trial protocol Abstract Abstract Introduction Linezolid is a broadly used antibiotic to treat complicated infections caused by gram-positiv... |
PMC12664903 | core_pubmed_pmc | A Single Dose, Randomized, Open‐Label, Cross‐Over Bioequivalence Study of Budesonide Pressurized Metered‐Dose Inhaler in Healthy Chinese Subjects | A Single Dose, Randomized, Open‐Label, Cross‐Over Bioequivalence Study of Budesonide Pressurized Metered‐Dose Inhaler in Healthy Chinese Subjects Abstract ABSTRACT Budesonide is a first‐line inhaled glucocorticoid (ICS) for asthma treatment in adults and children. The purpose of this study was to compare the pharmacoki... |
PMC3706980 | core_pubmed_pmc | Prospective cohort study of the circadian rhythm pattern in allogeneic sibling donors undergoing standard granulocyte colony-stimulating factor mobilization | Prospective cohort study of the circadian rhythm pattern in allogeneic sibling donors undergoing standard granulocyte colony-stimulating factor mobilization Abstract Introduction Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administratio... |
PMC8551406 | core_pubmed_pmc | CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics | CRISPR-Cas9: A method for establishing rat models of drug metabolism and pharmacokinetics Abstract The 2020 Nobel Prize in Chemistry recognized CRISPR-Cas9, a super-selective and precise gene editing tool. CRISPR-Cas9 has an obvious advantage in editing multiple genes in the same cell, and presents great potential in d... |
PMC12649284 | core_pubmed_pmc | Assessment of Telisotuzumab Vedotin Drug–Drug Interaction Potential Using Physiologically‐Based Pharmacokinetic Modeling and Simulations | Assessment of Telisotuzumab Vedotin Drug–Drug Interaction Potential Using Physiologically‐Based Pharmacokinetic Modeling and Simulations Abstract Abstract Telisotuzumab vedotin (Teliso‐V; ABBV‐399) is an antibody‐drug conjugate (ADC) comprised of the c‐Met targeting antibody telisotuzumab (ABT‐700) conjugated to the po... |
PMC10719486 | core_pubmed_pmc | Pharmacokinetic/LDL‐C and exposure–response analysis of tafolecimab in Chinese hypercholesterolemia patients: Results from phase I, II, and III studies | Pharmacokinetic/LDL‐C and exposure–response analysis of tafolecimab in Chinese hypercholesterolemia patients: Results from phase I, II, and III studies Abstract Abstract Tafolecimab, a novel fully human monoclonal antibody targeting PCSK9, has been assessed in Chinese healthy volunteers and patients with hypercholester... |
PMC4767189 | core_pubmed_pmc | Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression | Designing More Efficient Preclinical Experiments: A Simulation Study in Chemotherapy-Induced Myelosupression Abstract Abstract A new more efficient preclinical study design (referred to as a compact design) is proposed that removes the need for satellite animals for the collection of toxicokinetic (TK) data by sampling... |
PMC11503159 | core_pubmed_pmc | A doxorubicin loaded chitosan–poloxamer in situ implant for the treatment of breast cancer † | A doxorubicin loaded chitosan–poloxamer in situ implant for the treatment of breast cancer † Abstract Abstract Breast cancer is a serious concern for many women worldwide. Drug-loaded implants have shown several benefits over systemic administrations. To provide anti-cancer drugs with controlled release and reduced sys... |
PMC9024849 | core_pubmed_pmc | Pharmacokinetics of DA-6886, A New 5-HT 4 Receptor Agonist, in Rats | Pharmacokinetics of DA-6886, A New 5-HT 4 Receptor Agonist, in Rats Abstract DA-6886 is a novel serotonin (5-hydroxytrypamine [5-HT]) receptor 4 agonist for the potential treatment of constipation-predominant irritable bowel syndrome. The purpose of this study was to validate the quantitative assay of DA-6886 in rat pl... |
PMC5099554 | core_pubmed_pmc | Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach | Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach Abstract Aims We assessed the drug interaction profile of fermented red ginseng with respect to the activity of major cytochrome (CYP) P450 enzymes and of a drug transporter prote... |
PMC10703963 | core_pubmed_pmc | Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males | Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males Abstract Abstract Introduction Depression, anxiety, and/or panic disorder are often comorbid and have a complex etiology mediated through the same neuronal net... |
PMC5698755 | core_pubmed_pmc | Biosimilars: Key regulatory considerations and similarity assessment tools | Biosimilars: Key regulatory considerations and similarity assessment tools Abstract Abstract A biosimilar drug is defined in the US Food and Drug Administration (FDA) guidance document as a biopharmaceutical that is highly similar to an already licensed biologic product (referred to as the reference product) notwithsta... |
PMC12129647 | core_pubmed_pmc | Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia | Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia Abstract ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's diseas... |
PMC3421442 | core_pubmed_pmc | INDI: a computational framework for inferring drug interactions and their associated recommendations | INDI: a computational framework for inferring drug interactions and their associated recommendations Abstract Abstract Inferring drug–drug interactions (DDIs) is an essential step in drug development and drug administration. Most computational inference methods focus on modeling drug pharmacokinetics, aiming at interac... |
PMC4650854 | core_pubmed_pmc | In silico evaluation and exploration of antibiotic tuberculosis treatment regimens | In silico evaluation and exploration of antibiotic tuberculosis treatment regimens Abstract Background Improvement in tuberculosis treatment regimens requires selection of antibiotics and dosing schedules from a large design space of possibilities. Incomplete knowledge of antibiotic and host immune dynamics in tubercul... |
PMC10500909 | core_pubmed_pmc | Vancomycin and daptomycin dosing recommendations in patients receiving home hemodialysis using Monte Carlo simulation | Vancomycin and daptomycin dosing recommendations in patients receiving home hemodialysis using Monte Carlo simulation Abstract Abstract Background Few drug dosing recommendations for patients receiving home hemodialysis (HHD) have been published which has hindered the adoption of HHD. HHD regimens vary widely and diffe... |
PMC7232861 | core_pubmed_pmc | Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children | Adherence and Population Pharmacokinetic Properties of Amodiaquine When Used for Seasonal Malaria Chemoprevention in African Children Abstract Abstract Poor adherence to seasonal malaria chemoprevention (SMC) might affect the protective effectiveness of SMC. Here, we evaluated the population pharmacokinetic properties ... |
PMC8332564 | core_pubmed_pmc | Plasma Concentration and Pharmacodynamics of Edoxaban in Patients with Nonvalvular Atrial Fibrillation and Acute Heart Failure | Plasma Concentration and Pharmacodynamics of Edoxaban in Patients with Nonvalvular Atrial Fibrillation and Acute Heart Failure Abstract Abstract Objective The objective of this study was to assess the pharmacokinetic and pharmacodynamic profiles and safety of edoxaban in patients with nonvalvular atrial fibrillation (N... |
PMC11745015 | core_pubmed_pmc | A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer | A first-in-human study of JNJ-70218902, a bispecific T-cell-redirecting antibody against TMEFF2 in metastatic castration-resistant prostate cancer Abstract Abstract Background Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis, necessitating the investigation of novel treatments and targets. T... |
PMC12523034 | core_pubmed_pmc | Safety, pharmacokinetics and pharmacodynamics of Plozasiran in Chinese healthy volunteers | Safety, pharmacokinetics and pharmacodynamics of Plozasiran in Chinese healthy volunteers Abstract Background Plozasiran (VSA001, ARO-APOC3) is an RNA interference therapy that targets Apolipoprotein C3 (APOC3), a key regulator of lipoprotein metabolism. The study aimed at assessing the safety, tolerability, pharmacoki... |
PMC5051241 | core_pubmed_pmc | Evaluation of pharmacokinetics of single-dose chloroquine in malnourished children with malaria- a comparative study with normally nourished children | Evaluation of pharmacokinetics of single-dose chloroquine in malnourished children with malaria- a comparative study with normally nourished children Abstract Objectives: Studies on antimalarial kinetics in children or adults who are undernourished or malnourished are both limited and have yielded conflicting results. ... |
PMC5096281 | core_pubmed_pmc | Characterization and Bioavailability Study of Baicalin-mesoporous Carbon Nanopowder Solid Dispersion | Characterization and Bioavailability Study of Baicalin-mesoporous Carbon Nanopowder Solid Dispersion Abstract Background: Baicalin is the main bioactive constitute of the dried roots of Scutellaria baicalensis and possesses various biological activities. However, the poor water solubility and low oral bioavailability l... |
PMC8452302 | core_pubmed_pmc | Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling | Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling Abstract Abstract Quantitative assessment of drug‐drug interactions (DDIs) involving breast cancer resistance protein (BCRP) inhibition is challenged by overlapping substrate/i... |
PMC11276774 | core_pubmed_pmc | A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies | A New Tailored Nanodroplet Carrier of Astaxanthin Can Improve Its Pharmacokinetic Profile and Antioxidant and Anti-Inflammatory Efficacies Abstract Abstract Astaxanthin (ATX) is a carotenoid nutraceutical with poor bioavailability due to its high lipophilicity. We tested a new tailored nanodroplet capable of solubilizi... |
PMC10452628 | core_pubmed_pmc | Effect of Leflunomide–Metal Complexes on ROS, TNF, and Brain Indolamines in Comparison with Anti-Depressants as Adjunct Therapy in Rheumatoid Arthritic Model | Effect of Leflunomide–Metal Complexes on ROS, TNF, and Brain Indolamines in Comparison with Anti-Depressants as Adjunct Therapy in Rheumatoid Arthritic Model Abstract Leflunomide is an isoxazole immunomodulating drug used to treat rheumatoid arthritis (RA). It is adopted as a metal-containing molecule to proceed with s... |
PMC9953224 | core_pubmed_pmc | Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders | Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders Abstract Abstract Background and objective: The determination of pharmacokinetic properties of new chemical entities is a key step in the proces... |
PMC12505664 | core_pubmed_pmc | Enflicoxib for the long-term management of canine osteoarthritis—External validation of a population pharmacokinetic model in dogs with osteoarthritis | Enflicoxib for the long-term management of canine osteoarthritis—External validation of a population pharmacokinetic model in dogs with osteoarthritis Abstract Introduction Enflicoxib is a cyclooxygenase-2 (Cox-2) selective non-steroidal anti-inflammatory drug (NSAID) indicated for the treatment of pain and inflammatio... |
PMC10937462 | core_pubmed_pmc | Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report | Successful switch to ofatumumab after liver injury associated with ocrelizumab treatment in multiple sclerosis: a case report Abstract Abstract Drug-induced liver injury (DILI) is a potential adverse event of disease-modifying therapies (DMTs) for the treatment of multiple sclerosis (MS), as well as of methylprednisolo... |
PMC12114857 | core_pubmed_pmc | In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets † | In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets † Abstract Abstract Background: Physiologically based biopharmaceutics modeling (PBBM) models can help to predict drug release and in vivo absorption behaviors. Colon drug delivery syst... |
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