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PMC6327336 | core_pubmed_pmc | Potential Anti-Cancer Flavonoids Isolated From Caesalpinia bonduc Young Twigs and Leaves: Molecular Docking and In Silico Studies | Potential Anti-Cancer Flavonoids Isolated From Caesalpinia bonduc Young Twigs and Leaves: Molecular Docking and In Silico Studies Abstract Abstract Tyrosine kinase (TK), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMP) are important cancer therapeutic target proteins. Based on reported ant... |
PMC3794864 | core_pubmed_pmc | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study Abstract The systemic bioavailability of free fatty acid (FFA) forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid ... |
PMC8590161 | core_pubmed_pmc | Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model | Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model Abstract Purpose Current melphalan-based regimens for intravitreal chemotherapy for retinoblastoma vitreous seeds are effective but toxic to the retina. Thus, alternative agents... |
PMC12177941 | core_pubmed_pmc | Rational Design of Safer Inorganic Nanoparticles via Mechanistic Modeling-Informed Machine Learning | Rational Design of Safer Inorganic Nanoparticles via Mechanistic Modeling-Informed Machine Learning Abstract The safety of inorganic nanoparticles (NPs) remains a critical challenge for their clinical translation. To address this, we developed a machine learning (ML) framework that predicts NP toxicity both in vitro an... |
PMC6189874 | core_pubmed_pmc | Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future | Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future Abstract Abstract β-Lactams represent perhaps the most important class of antibiotics yet discovered. However, despite many years of active research, none of the currently approved drugs in this class com... |
PMC9604962 | core_pubmed_pmc | Insights into CD24 and Exosome Physiology and Potential Role in View of Recent Advances in COVID-19 Therapeutics: A Narrative Review | Insights into CD24 and Exosome Physiology and Potential Role in View of Recent Advances in COVID-19 Therapeutics: A Narrative Review Abstract Abstract Cluster of differentiation (CD) 24, a long-known protein with multifaceted functions, has gained attention as a possible treatment for Coronavirus Disease 19 (COVID-19) ... |
PMC2958653 | core_pubmed_pmc | Developmental Pharmacogenetics in Pediatric Rheumatology: Utilizing a New Paradigm to Effectively Treat Patients with Juvenile Idiopathic Arthritis with Methotrexate | Developmental Pharmacogenetics in Pediatric Rheumatology: Utilizing a New Paradigm to Effectively Treat Patients with Juvenile Idiopathic Arthritis with Methotrexate Abstract Abstract Although methotrexate is widely used in clinical practice there remains significant lack of understanding of its mechanisms of action an... |
PMC12395082 | core_pubmed_pmc | Computational modeling of drug-eluting balloons in peripheral artery disease: Mechanisms, optimization, and translational insights | Computational modeling of drug-eluting balloons in peripheral artery disease: Mechanisms, optimization, and translational insights Abstract Abstract Drug-eluting balloons (DEBs) represent a promising alternative to stent-based interventions for peripheral artery disease (PAD), and their therapeutic efficacy is dependen... |
PMC12491691 | core_pubmed_pmc | Metallic nanomedicine in cancer immunotherapy | Metallic nanomedicine in cancer immunotherapy Abstract Immunotherapy has become a pivotal modality in clinical cancer treatment. However, its effectiveness is limited to a small subset of patients due to the low antigenicity, impaired innate response, and various adaptive immune resistance mechanisms of the tumor micro... |
PMC8253325 | core_pubmed_pmc | Evaluation of pharmacokinetics of single-dose primaquine in undernourished versus normally nourished children diagnosed with Plasmodium vivax malaria in Mumbai | Evaluation of pharmacokinetics of single-dose primaquine in undernourished versus normally nourished children diagnosed with Plasmodium vivax malaria in Mumbai Abstract Abstract Background: The pharmacokinetics of primaquine [PQ] have been the subject of studies in both adults and healthy participants. However, there i... |
PMC12840083 | core_pubmed_pmc | Targeting CRHR1 Signaling in Experimental Infantile Epileptic Spasms Syndrome: Evidence for Route-Dependent Efficacy | Targeting CRHR1 Signaling in Experimental Infantile Epileptic Spasms Syndrome: Evidence for Route-Dependent Efficacy Abstract Abstract Highlights What are the main findings? CRHR1 antagonists suppress experimental infantile spasms in a route-, drug-, and brain-site-specific manner. Systemic SN003 reduces spasms, wherea... |
PMC4702464 | core_pubmed_pmc | Intranasal Human Growth Hormone (hGH) Induces IGF-1 Levels Comparable With Subcutaneous Injection With Lower Systemic Exposure to hGH in Healthy Volunteers | Intranasal Human Growth Hormone (hGH) Induces IGF-1 Levels Comparable With Subcutaneous Injection With Lower Systemic Exposure to hGH in Healthy Volunteers Abstract Context: The development of an improved, efficacious human GH (hGH) product administered by a noninjectable route of delivery such as the nasal route is hi... |
PMC11445346 | core_pubmed_pmc | Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study | Preparation and characterization of Sorafenib nano-emulsion: impact on pharmacokinetics and toxicity; an in vitro and in vivo study Abstract Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related deaths worldwide. Current treatment strategies include surgical resection, liver transplantation,... |
PMC12525650 | core_pubmed_pmc | Pharmacokinetic Profile of Extracts from the Chayote ( Sechium edule ) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications | Pharmacokinetic Profile of Extracts from the Chayote ( Sechium edule ) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications Abstract Abstract The hybrid Sechium edule H387 07, commonly known as chayote, has shown potential as an antiproliferative, cytotoxic,... |
PMC8309110 | core_pubmed_pmc | Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies | Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies Abstract This study was conducted to develop a rapid, simple and reproducible method for the quantification of ceftaroline in plasma samples by high-performance l... |
PMC12521055 | core_pubmed_pmc | Machine Learning‐Based Model Selection and Averaging Outperform Single‐Model Approaches for a Priori Vancomycin Precision Dosing | Machine Learning‐Based Model Selection and Averaging Outperform Single‐Model Approaches for a Priori Vancomycin Precision Dosing Abstract ABSTRACT Selecting an appropriate population pharmacokinetic (PK) model for individual patients in model‐informed precision dosing (MIPD) can be challenging, particularly in the abse... |
PMC9144954 | core_pubmed_pmc | Epidural Oxycodone for Acute Pain | Epidural Oxycodone for Acute Pain Abstract Epidural analgesia is commonly used in labour analgesia and in postoperative pain after major surgery. It is highly effective in severe acute pain, has minimal effects on foetus and newborn, may reduce postoperative complications, and enhance patient satisfaction. In epidural ... |
PMC11732092 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review | Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review Abstract Orthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-t... |
PMC2829539 | core_pubmed_pmc | Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes | Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes Abstract Background The reduced drug accumulation based on enhanced drug efflux and metabolic capacity, identified in triclabendazole (TCBZ)-resi... |
PMC12845070 | core_pubmed_pmc | Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle | Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle Abstract Background/Objectives : Given the clinical limitations of azathioprine (AZA) in treating inflammatory bowel dise... |
PMC6205597 | core_pubmed_pmc | Faster emergence behavior from ketamine/xylazine anesthesia with atipamezole versus yohimbine | Faster emergence behavior from ketamine/xylazine anesthesia with atipamezole versus yohimbine Abstract Recent interest in reversal of the hypnotic effects of anesthesia has mainly focused on overcoming a surge in GABA-mediated inhibitory signaling through activation of subcortical arousal circuits or antagonizing GABA ... |
PMC12364634 | core_pubmed_pmc | Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr) | Trial in progress: phase I study of non-viral gene-modified CAR-T cell therapy for malignant solid tumors expressing EPHB4 receptor (CARTiEr) Abstract Abstract Background Ephrin type-B receptor 4 (EPHB4) is overexpressed on the surface of various tumor cells, including cells from malignant bone and soft-tissue tumors. ... |
PMC11766596 | core_pubmed_pmc | Efficacy and Safety Assessment of Antifungal Prophylaxis with Posaconazole Using Therapeutic Drug Monitoring in Pediatric Patients with Oncohematological Disorders—A Single-Centre Study | Efficacy and Safety Assessment of Antifungal Prophylaxis with Posaconazole Using Therapeutic Drug Monitoring in Pediatric Patients with Oncohematological Disorders—A Single-Centre Study Abstract Introduction: Posaconazole is recommended for prophylaxis in pediatric immunocompromised patients. Due to its variability in ... |
PMC8130657 | core_pubmed_pmc | The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs | The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs Abstract Abstract There is evidence that use of drugs with anticholinergic properties increases the risk of cognitive impairment, and increased exposure to these drugs potentiates this risk. Anticholinergic dr... |
PMC3589633 | core_pubmed_pmc | A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors | A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors Abstract Summary Background This trial evaluated the safety, tolerability and maximum tolerated dose (MTD) of afatinib, a novel ErbB Family Blocker. Methods In this open-label, dose-... |
PMC5836974 | core_pubmed_pmc | Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study * | Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study * Abstract Abstract Background and Aims Take‐home naloxone can prevent death from heroin/opioid overdose, but pre‐provision is difficult because naloxone is usually given by injection. Non‐injectable alte... |
PMC4964204 | core_pubmed_pmc | Invasiveness of pharmacokinetic studies in children: a systematic review | Invasiveness of pharmacokinetic studies in children: a systematic review Abstract Abstract Objectives To explore whether pharmacokinetic (PK) studies in paediatric patients are becoming less invasive. This will be evaluated by analysing the number of samples and volume of blood collected for each study within four diff... |
PMC6678684 | core_pubmed_pmc | Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use | Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use Abstract Abstract Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer products for complementary health or recreational use. CBD has intrinsic pharmacologic effects and associated a... |
PMC10465962 | core_pubmed_pmc | Metabolomics in drug research and development: The recent advances in technologies and applications | Metabolomics in drug research and development: The recent advances in technologies and applications Abstract Abstract Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of metabolism in biological systems. With advanced a... |
PMC11730072 | core_pubmed_pmc | Risk Factors and Patterns of Drug‐Drug Interactions in Two Categories of Level‐3 Hospitals in Dhaka: A Cross‐Sectional Study | Risk Factors and Patterns of Drug‐Drug Interactions in Two Categories of Level‐3 Hospitals in Dhaka: A Cross‐Sectional Study Abstract ABSTRACT Background and Aims Drug‐drug interactions (DDIs) are a significant health issue that may adversely affect the health and well‐being of patients. This study assesses and compare... |
PMC5599956 | core_pubmed_pmc | Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study | Effect of Food Intake on the Pharmacodynamics of Tenapanor: A Phase 1 Study Abstract Abstract Tenapanor (RDX5791/AZD1722) is a minimally systemic small‐molecule inhibitor of the sodium/hydrogen exchanger NHE3. Tenapanor acts in the gut to reduce absorption of sodium and phosphate. This phase 1 open‐label, 3‐way crossov... |
PMC6267664 | core_pubmed_pmc | Phase I trial of afatinib and 3-weekly trastuzumab with optimal anti-diarrheal management in patients with HER2-positive metastatic cancer | Phase I trial of afatinib and 3-weekly trastuzumab with optimal anti-diarrheal management in patients with HER2-positive metastatic cancer Abstract Background Trastuzumab is the mainstay of therapy for patients with HER2-positive breast and gastric cancer but resistance frequently occurs. Afatinib, an irreversible oral... |
PMC6895912 | core_pubmed_pmc | Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo | Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo Abstract Abstract These studies compared the efficacies of our clinical agent galeterone (Gal) and the FDA-approved prostat... |
PMC6030777 | core_pubmed_pmc | Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations | Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations Abstract Background Ambroxol relieves cough symptoms based on its secretagogue, anti-inflammatory, anti-oxidant, anti-bacterial, anti-viral, immunomodulatory and local anesthetic effects. The... |
PMC9930700 | core_pubmed_pmc | Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects | Results From a Randomized, Open-Label, Crossover Study Evaluating the Effect of the Aldosterone Synthase Inhibitor Baxdrostat on the Pharmacokinetics of Metformin in Healthy Human Subjects Abstract Background Due to the high comorbidity of diabetes and hypertension, co-administration of metformin with anti-hypertensive... |
PMC11988034 | core_pubmed_pmc | Exposure–Response Relationships for Toceranib in Dogs with Solid Tumors: A Pilot Study | Exposure–Response Relationships for Toceranib in Dogs with Solid Tumors: A Pilot Study Abstract Simple Summary Toceranib phosphate, the most commonly used tyrosine kinase inhibitor in veterinary oncology, meets most of the criteria for therapeutic drug monitoring (TDM); however, its exposure–response relationships have... |
PMC4320559 | core_pubmed_pmc | Efficacy of intranasal administration of artesunate in experimental cerebral malaria | Efficacy of intranasal administration of artesunate in experimental cerebral malaria Abstract Abstract Background Improving management of patients suffering from cerebral malaria is needed to reduce the devastating mortality and morbidity of the disease in endemic areas. Intravenous artesunate is currently the first-li... |
PMC10042133 | core_pubmed_pmc | The use of nanoparticles for targeted drug delivery in non-small cell lung cancer | The use of nanoparticles for targeted drug delivery in non-small cell lung cancer Abstract Lung cancer is a global health problem affecting millions of people each year. Non-small cell lung cancer (NSCLC) is the most common form of lung cancer with various conventional treatment available in the clinic. Application of ... |
PMC3797760 | core_pubmed_pmc | Influence of Obstructive Jaundice on Pharmacodynamics of Rocuronium | Influence of Obstructive Jaundice on Pharmacodynamics of Rocuronium Abstract Background Anesthetics are variable in patients with obstructive jaundice. The minimum alveolar concentration awake of desflurane is reduced in patients with obstructive jaundice, while it has no effect on pharmacodynamics and pharmacokinetics... |
PMC10386724 | core_pubmed_pmc | Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir | Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir Abstract Background: Ganciclovir and valganciclovir are used for prophylaxis and treatment of cytomegalovirus infection. However, there is great interindividual variability in ganciclovir’s pharma... |
PMC7823237 | core_pubmed_pmc | Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan | Optimal Monitoring of Weekly IGF-I Levels During Growth Hormone Therapy With Once-Weekly Somapacitan Abstract Abstract Context Somapacitan is a long-acting growth hormone (GH) in development for once-weekly treatment of GH deficiency (GHD). Optimal monitoring of insulin-like growth factor-I (IGF-I) levels must account ... |
PMC8024110 | core_pubmed_pmc | Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19 | Rational design of flavonoid based potential inhibitors targeting SARS-CoV 3CL protease for the treatment of COVID-19 Abstract Abstract The current outbreak of Coronavirus Disease 2019 (COVID-19) pandemic has reported thousands of deaths worldwide due to the rapid transmission rate and the lack of antiviral drugs and v... |
PMC11384081 | core_pubmed_pmc | Population-based model selection for an accurate estimation of time-integrated activity using non-linear mixed-effects modelling | Population-based model selection for an accurate estimation of time-integrated activity using non-linear mixed-effects modelling Abstract Purpose Personalized treatment planning in Molecular Radiotherapy (MRT) with accurately determining the absorbed dose is highly desirable. The absorbed dose is calculated based on th... |
PMC8047826 | core_pubmed_pmc | Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis | Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis Abstract Abstract Background: Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are a bothersome frequent symptom in adult... |
PMC5340007 | core_pubmed_pmc | A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors | A phase I dose-escalation study of selumetinib in combination with docetaxel or dacarbazine in patients with advanced solid tumors Abstract Abstract Background The RAS/RAF/MEK/ERK pathway is constitutively activated in many cancers. Selumetinib (AZD6244, ARRY-142886) is an oral, potent and highly selective, allosteric ... |
PMC11335869 | core_pubmed_pmc | Physiologically-based pharmacokinetic/pharmacodynamic modeling of meropenem in critically ill patients | Physiologically-based pharmacokinetic/pharmacodynamic modeling of meropenem in critically ill patients Abstract This study aimed to develop a physiologically based pharmacokinetic/pharmacodynamic model (PBPK/PD) of meropenem for critically ill patients. A PBPK model of meropenem in healthy adults was established using ... |
PMC11094190 | core_pubmed_pmc | A simple and highly sensitive LC–MS workflow for characterization and quantification of ADC cleavable payloads | A simple and highly sensitive LC–MS workflow for characterization and quantification of ADC cleavable payloads Abstract Abstract Antibody–drug conjugates (ADC) payloads are cleavable drugs that act as the warhead to exert an ADC’s cytotoxic effects on cancer cells intracellularly. A simple and highly sensitive workflow... |
PMC10145339 | core_pubmed_pmc | Influence of Intramuscular Injection Sites on Pharmacokinetics of Amoxicillin in Olive Flounder ( Paralichthys olivaceus ) and Its Implication for Antibacterial Efficacy | Influence of Intramuscular Injection Sites on Pharmacokinetics of Amoxicillin in Olive Flounder ( Paralichthys olivaceus ) and Its Implication for Antibacterial Efficacy Abstract Abstract This study aimed to investigate the effects of different injection sites, including dorsal, cheek, and pectoral fin muscles, on the ... |
PMC8000608 | core_pubmed_pmc | Receptor-Based Pharmacophore Modeling in the Search for Natural Products for COVID-19 M pro | Receptor-Based Pharmacophore Modeling in the Search for Natural Products for COVID-19 M pro Abstract Abstract Considering the urgency of the COVID-19 pandemic, we developed a receptor-based pharmacophore model for identifying FDA-approved drugs and hits from natural products. The COVID-19 main protease (M pro ) was sel... |
PMC7081932 | core_pubmed_pmc | Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique | Preparation, characterization, and in vitro/vivo evaluation of polymer-assisting formulation of atorvastatin calcium based on solid dispersion technique Abstract Due to low solubility and bioavailability, atorvastatin calcium is confronted with challenge in conceiving appropriate formulation. Solid dispersion of atorva... |
PMC12524202 | core_pubmed_pmc | Liver-Specific Nanoparticle-Mediated Delivery and MMP-Triggered Release of Veratridine to Effectively Target Metastatic Colorectal Cancer | Liver-Specific Nanoparticle-Mediated Delivery and MMP-Triggered Release of Veratridine to Effectively Target Metastatic Colorectal Cancer Abstract Abstract Simple Summary Encapsulating an anti-metastatic molecule, veratridine (VTD), by mesoporous silica nanoparticles (MSNs) and calcium carbonate submicroparticles (CCSM... |
PMC10309101 | core_pubmed_pmc | Characterization of Extended-Release Lorazepam | Characterization of Extended-Release Lorazepam Abstract Purpose/Background Once-daily extended-release (ER) lorazepam was developed to reduce fluctuations in plasma levels compared with lorazepam immediate-release (IR) for short-term anxiety relief. Here we report a series of phase 1 randomized, open-label, multiperiod... |
PMC11775251 | core_pubmed_pmc | Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection | Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection Abstract Abstract Enterococcus faecalis is responsible for numerous serious infections, and treatment options often include ampicillin combined with an aminoglycoside or dual... |
PMC11094416 | core_pubmed_pmc | Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses | Lipid-Encapsulated mRNAs Encoding Complex Fusion Proteins Potentiate Antitumor Immune Responses Abstract Abstract Lipid nanoparticle (LNP)–encapsulated mRNA has been used for in vivo production of several secreted protein classes, such as IgG, and has enabled the development of personalized vaccines in oncology. Establ... |
PMC12254004 | core_pubmed_pmc | Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies | Exosomal delivery of IL-10: Biodistribution, pharmacokinetics, and preterm birth prevention strategies Abstract Abstract This study investigates the potential of extracellular vesicles (EVs) loaded with interleukin-10 (IL-10) to reduce infection-induced preterm birth (PTB). IL-10 has shown promise in reducing PTB by da... |
PMC12354565 | core_pubmed_pmc | Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study | Influence of Pharmacokinetic-Pharmacodynamic Failure Mechanisms on Outcomes in Biologic Therapy Sequencing in Inflammatory Bowel Disease: A Retrospective Cohort Study Abstract Background Increasing therapeutic options for inflammatory bowel disease calls for tools to aid choice of sequencing. We investigated if pharmac... |
PMC12409547 | core_pubmed_pmc | Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody–Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms | Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody–Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms Abstract Antibody–drug conjugates (ADCs) represent a transformative class of cancer therapies that combine the specificity of monoclonal antibodies with the cytotoxicity of potent d... |
PMC8374649 | core_pubmed_pmc | IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study | IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study Abstract Background IBI362 (LY3305677) is a novel weekly-dose glucagon-like peptide-1 and glucagon receptor dual agonist bein... |
PMC11570808 | core_pubmed_pmc | JAK inhibitors: an evidence-based choice of the most appropriate molecule | JAK inhibitors: an evidence-based choice of the most appropriate molecule Abstract Janus kinase inhibitors (JAKis) represent a fundamental therapeutic tool for the treatment of patients with immune-mediated inflammatory diseases. Although JAKis are often considered a homogeneous class of drugs whose members are thought... |
PMC12784194 | core_pubmed_pmc | Comprehensive pharmacokinetic/pharmacodynamic analysis of commercially available premixed daptomycin preparations against Staphylococcus aureus and Enterococcus spp. bloodstream infections using Monte Carlo simulation in adult patients | Comprehensive pharmacokinetic/pharmacodynamic analysis of commercially available premixed daptomycin preparations against Staphylococcus aureus and Enterococcus spp. bloodstream infections using Monte Carlo simulation in adult patients Abstract Abstract Objectives The current approach to dosing daptomycin is primarily ... |
PMC12781667 | core_pubmed_pmc | Management of anticoagulation in patients with atrial fibrillation and renal dysfunction: A systematic review | Management of anticoagulation in patients with atrial fibrillation and renal dysfunction: A systematic review Abstract BACKGROUND Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with significant morbidity and mortality, particularly in patients with concomitant renal dysfunction. Anticoagulation t... |
PMC9416163 | core_pubmed_pmc | Antiproliferative Copper(II) Complexes Bearing Mixed Chelating Ligands: Structural Characterization, ROS Scavenging, In Silico Studies, and Anti-Melanoma Activity | Antiproliferative Copper(II) Complexes Bearing Mixed Chelating Ligands: Structural Characterization, ROS Scavenging, In Silico Studies, and Anti-Melanoma Activity Abstract Melanoma is a skin cancer characterized by rapid growth and spread for which current therapies produce both resistance and increased risk of infecti... |
PMC10053447 | core_pubmed_pmc | Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles | Oral Administration as a Potential Alternative for the Delivery of Small Extracellular Vesicles Abstract Abstract Small extracellular vesicles (sEVs) have burst into biomedicine as a natural therapeutic alternative for different diseases. Considered nanocarriers of biological origin, various studies have demonstrated t... |
PMC11923969 | core_pubmed_pmc | Supramolecular Modulation of Tumor Microenvironment Through Host−Guest Recognition and Metal Coordination to Potentiate Cancer Chemoimmunotherapy | Supramolecular Modulation of Tumor Microenvironment Through Host−Guest Recognition and Metal Coordination to Potentiate Cancer Chemoimmunotherapy Abstract Abstract The massive amount of indoleamine 2,3‐dioxygenase 1 (IDO‐1) in tumor cells and tumor‐associated immune cells forms a feedback loop that maintains immunosupp... |
PMC7935699 | core_pubmed_pmc | Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs | Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs Abstract Abstract Tuberculosis (TB) is still the number one cause of death due to an infectious disease. Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB treatment and help to prevent slow re... |
PMC9795234 | core_pubmed_pmc | Mathematical modeling of antihypertensive therapy | Mathematical modeling of antihypertensive therapy Abstract Hypertension is a multifactorial disease arising from complex pathophysiological pathways. Individual characteristics of patients result in different responses to various classes of antihypertensive medications. Therefore, evaluating the efficacy of therapy bas... |
PMC9541865 | core_pubmed_pmc | Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure | Clinical Pharmacology of Insulin Aspart Biosimilar GP40071: Pharmacokinetic/Pharmacodynamic Comparability in Hyperinsulinemic Euglycemic Clamp Procedure Abstract Abstract Insulin aspart is a short‐acting insulin analogue that is used to control postprandial glycemia levels in diabetic patients. The aim of this clinical... |
PMC9056957 | core_pubmed_pmc | Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal † | Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal † Abstract PEC is a new generation of phosphamide ester anti-hepatitis B virus drug. It is a prodrug of tenofovir and can be rapidly metabolized to tenofovir. However, its poor solubility in water (0.219 mg mL −1 at... |
PMC4346004 | core_pubmed_pmc | New insights into the use of currently available non-steroidal anti-inflammatory drugs | New insights into the use of currently available non-steroidal anti-inflammatory drugs Abstract Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a key component of the pharmacological management of acute a... |
PMC8683663 | core_pubmed_pmc | Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro - in vivo correlation of P-glycoprotein inhibition | Oral etoposide and zosuquidar bioavailability in rats: Effect of co-administration and in vitro - in vivo correlation of P-glycoprotein inhibition Abstract P-glycoprotein inhibitors, like zosuquidar, have widely been used to study the role of P-glycoprotein in oral absorption. Still, systematic studies on the inhibitor... |
PMC11106146 | core_pubmed_pmc | Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole | Personalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole Abstract Background and Objective Posaconazole is a pharmacotherapeutic pillar for prophylaxis and treatment of invasive fungal diseases. Dose individualization is of utmost importance as achieving adequate antifungal exposure is as... |
PMC12596047 | core_pubmed_pmc | Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis | Antagonistic interaction between posaconazole and olorofim in a murine model of invasive pulmonary aspergillosis Abstract Abstract Background Olorofim is a new antifungal agent with a novel mechanism of action with in vitro activity against Aspergillus fumigatus and other clinically important moulds. As antifungal comb... |
PMC11781947 | core_pubmed_pmc | Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women | Transfer of the Oral Gonadotropin‐Releasing Hormone Receptor Antagonist Relugolix Into Breast Milk of Healthy Lactating Women Abstract ABSTRACT Relugolix is an oral gonadotropin‐releasing hormone receptor antagonist that suppresses sex steroid hormones and is approved as monotherapy for prostate cancer and as a fixed‐d... |
PMC9674622 | core_pubmed_pmc | Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification | Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification Abstract Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tis... |
PMC7398395 | core_pubmed_pmc | A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir: a study of HIV-infected Zimbabwean adolescents | A population pharmacokinetic model is beneficial in quantifying hair concentrations of ritonavir-boosted atazanavir: a study of HIV-infected Zimbabwean adolescents Abstract Background Adolescents experience higher levels of non-adherence to HIV treatment. Drug concentration in hair promises to be reliable for assessing... |
PMC7195552 | core_pubmed_pmc | Efficacy and Safety of High Vs Standard Daptomycin Doses Examined in Chinese Patients With Severe Burn Injuries by Pharmacokinetic Evaluation | Efficacy and Safety of High Vs Standard Daptomycin Doses Examined in Chinese Patients With Severe Burn Injuries by Pharmacokinetic Evaluation Abstract Abstract Previous studies and the concentration-dependent antibacterial actions of daptomycin suggested that a high dose would be needed for difficult-to-treat infection... |
PMC10301358 | core_pubmed_pmc | Prediction of CYP-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Modeling: A Case Study of Salbutamol and Fluvoxamine | Prediction of CYP-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Modeling: A Case Study of Salbutamol and Fluvoxamine Abstract Abstract Drug–drug interactions (DDIs) represent a significant concern in healthcare, particularly for patients undergoing polytherapy. DDIs can lead to a range of outcom... |
PMC9301199 | core_pubmed_pmc | Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray | Semi-PBPK Modeling and Simulation to Evaluate the Local and Systemic Pharmacokinetics of OC-01(Varenicline) Nasal Spray Abstract This study aimed to build a nasal semi-physiologically based pharmacokinetic (PBPK) model to predict the intranasal pharmacokinetic (PK) of the OC-01(varenicline) nasal spray and accelerate t... |
PMC9290993 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double‐blind, placebo‐controlled, dose‐titration trial | Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double‐blind, placebo‐controlled, dose‐titration trial Abstract Abstract Introduction/Aims Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting ... |
PMC7617756 | core_pubmed_pmc | Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV) | Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV) Abstract Summary Background Effective antiviral drugs prevent hospitalisation and death from COVID-19. An... |
PMC7775628 | core_pubmed_pmc | Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis | Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis Abstract Abstract Background Hypercholesterolemia has posed a serious threat of heart diseases and stroke worldwide. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid biosynthesis, is regarded... |
PMC7318171 | core_pubmed_pmc | Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling | Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling Abstract Abstract Abemaciclib, a selective inhibitor of cyclin‐dependent kinases 4 and 6, is metabolized mainly by cytochrome P450 (CYP)3A4. Clinical studies were performe... |
PMC7982486 | core_pubmed_pmc | Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis | Simplified Dosing Regimens for Gentamicin in Neonatal Sepsis Abstract Abstract Background: The effectiveness of antibiotics for the treatment of severe bacterial infections in newborns in resource-limited settings has been determined by empirical evidence. However, such an approach does not warrant optimal exposure to ... |
PMC12608915 | core_pubmed_pmc | Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy | Unlocking Mangiferin: A Therapeutic Candidate Revolutionizing Liver Disease Therapy Abstract Abstract Mangiferin (MF), a natural component widely found in fruits, vegetables, and herbs, has garnered increasing attention for its potent antioxidative properties and therapeutic potential. This bioactive xanthone compound ... |
PMC12816422 | core_pubmed_pmc | Model‐Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia | Model‐Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia Abstract Model‐informed drug development (MIDD) played a crucial role in the successful development and regulatory approval of daprodustat, a novel oral hypoxia‐inducible ... |
PMC12523803 | core_pubmed_pmc | Glycoengineering of plant-produced Pembrolizumab enhances FcRn binding and extends serum half-life in mice | Glycoengineering of plant-produced Pembrolizumab enhances FcRn binding and extends serum half-life in mice Abstract Abstract Plant systems offer scalable and cost-effective platforms for antibody production, but plant-specific glycans may affect pharmacokinetics and immunogenicity. To evaluate the impact of Fc glycosyl... |
PMC11904623 | core_pubmed_pmc | Challenges and opportunities in uncertainty quantification for healthcare and biological systems | Challenges and opportunities in uncertainty quantification for healthcare and biological systems Abstract Abstract Uncertainty quantification (UQ) is an essential aspect of computational modelling and statistical prediction. Multiple applications, including geophysics, climate science and aerospace engineering, incorpo... |
PMC4020257 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics, safety and tolerability of 4 weeks' treatment with empagliflozin in Japanese patients with type 2 diabetes mellitus | Pharmacokinetics, pharmacodynamics, safety and tolerability of 4 weeks' treatment with empagliflozin in Japanese patients with type 2 diabetes mellitus Abstract Abstract Introduction To evaluate the pharmacodynamics, pharmacokinetics, safety and tolerability of empagliflozin in Japanese patients with type 2 diabetes me... |
PMC4426534 | core_pubmed_pmc | Estimation of creatinine clearance using plasma creatinine or cystatin C: a secondary analysis of two pharmacokinetic studies in surgical ICU patients | Estimation of creatinine clearance using plasma creatinine or cystatin C: a secondary analysis of two pharmacokinetic studies in surgical ICU patients Abstract Abstract Background In ICU patients, glomerular filtration is often impaired, but also supraphysiological values are observed (“augmented renal clearance”, >130... |
PMC4767861 | core_pubmed_pmc | A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities | A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities Abstract The maximally tolerated dose (MTD) of cytotoxic agents has historical precedence in treating cancer, as it was believed that dose and therapeutic effect are intrinsically linked an... |
PMC10916623 | core_pubmed_pmc | Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents | Tissue distribution and pharmacokinetics of isoxanthohumol from hops in rodents Abstract Abstract Vegetables and fruits contain prenylflavonoids with biological functions that might improve human health. The prenylflavonoid isoxanthohumol (IXA) and its derivative, 8‐prenylnaringenin (8‐PN), have beneficial activities, ... |
PMC6201592 | core_pubmed_pmc | Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats | Pharmacokinetics and tissue distribution of monotropein and deacetyl asperulosidic acid after oral administration of extracts from Morinda officinalis root in rats Abstract Abstract Background Iridoid glycosides (IGs), including monotropein (MON) and deacetyl asperulosidic acid (DA) as the main ingredients, are the maj... |
PMC4426839 | core_pubmed_pmc | ADME SARfari: comparative genomics of drug metabolizing systems | ADME SARfari: comparative genomics of drug metabolizing systems Abstract Abstract Motivation: ADME SARfari is a freely available web resource that enables comparative analyses of drug-disposition genes. It does so by integrating a number of publicly available data sources, which have subsequently been used to build dat... |
PMC10467640 | core_pubmed_pmc | Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review | Current Status of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension: A Combined Study Results and Pharmacology-Based Review Abstract Pulmonary arterial hypertension (PAH) affects a wide range of people globally and has a poor prognosis despite many advancements in available treatment options. Among the... |
PMC11141576 | core_pubmed_pmc | Population Pharmacokinetic Models of Venetoclax in Hematologic Malignancies: A Systematic Review | Population Pharmacokinetic Models of Venetoclax in Hematologic Malignancies: A Systematic Review Abstract Abstract Several population pharmacokinetic (PPK) models of B cell lymphoma-2 (BCL-2) venetoclax (VEN) have been developed and published to characterize the influencing factors of pharmacokinetics in hematologic ma... |
PMC11387684 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of low doses of recombinant tissue plasminogen activator to establish a model for biosimilarity comparisons | Pharmacokinetics and pharmacodynamics of low doses of recombinant tissue plasminogen activator to establish a model for biosimilarity comparisons Abstract Background Recombinant tissue plasminogen activator (rt-PA) is a thrombolytic agent and essential in emergency medical care. Given recent supply shortages, the avail... |
PMC5613178 | core_pubmed_pmc | Determination of Plasma Concentration Reference Ranges for Risperidone and Paliperidone | Determination of Plasma Concentration Reference Ranges for Risperidone and Paliperidone Abstract Schizophrenia is a common disease managed by a range of interventions, with the primary treatment being antipsychotic medications (APS). Inadequate response, lack of adherence, and/or adverse events often prevent optimal th... |
PMC12472293 | core_pubmed_pmc | Characterizing Population Pharmacokinetics of Vatiquinone in Healthy Volunteers and Patients with Friedreich’s Ataxia | Characterizing Population Pharmacokinetics of Vatiquinone in Healthy Volunteers and Patients with Friedreich’s Ataxia Abstract Introduction: Vatiquinone is a first-in-class, small molecule designed to maintain mitochondrial function in the disorders like Friedreich’s ataxia (FA). Vatiquinone inhibits 15-lipoxygenase, c... |
PMC12852546 | core_pubmed_pmc | Evaluation of INR101, a PSMA-Targeted 18 F PET Tracer, for suspected prostate cancer: A multicenter phase I/IIa trial with histopathologic confirmation | Evaluation of INR101, a PSMA-Targeted 18 F PET Tracer, for suspected prostate cancer: A multicenter phase I/IIa trial with histopathologic confirmation Abstract Background Prostate cancer (PCa) is one of the most common malignancies among men worldwide. Early detection relies heavily on imaging accuracy, yet convention... |
PMC12554956 | core_pubmed_pmc | Structure-based screening and molecular dynamics of phytophytochemicals against pseudomonas aeruginosa quorum sensing systems | Structure-based screening and molecular dynamics of phytophytochemicals against pseudomonas aeruginosa quorum sensing systems Abstract Abstract Pseudomonas aeruginosa employs quorum sensing (QS) to regulate virulence and antibiotic resistance, making QS inhibition a promising anti-infective strategy. Here, we computati... |
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