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PMC6033053 | core_pubmed_pmc | A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT) | A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT) Abstract Abstract MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These ... |
PMC12034077 | core_pubmed_pmc | Aligning kidney function assessment in patients with cancer to global practices in internal medicine | Aligning kidney function assessment in patients with cancer to global practices in internal medicine Abstract Summary The kidney disease: Improving Global Outcomes (KDIGO) guideline recommends assessing kidney function using glomerular filtration rate (GFR) either through direct measurement or through estimation (eGFR)... |
PMC6268962 | core_pubmed_pmc | The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients | The Effect of β-Carotene Supplementation on the Pharmacokinetics of Nelfinavir and Its Active Metabolite M8 in HIV-1-infected Patients Abstract β-Carotene supplements are often taken by individuals living with HIV-1. Contradictory results from in vitro studies suggest that β-carotene may inhibit or induce cytochrome P4... |
PMC5623333 | core_pubmed_pmc | Pharmacokinetics of marbofloxacin administered via intravenous regional limb perfusion in dairy cows: evaluation of two different tourniquets | Pharmacokinetics of marbofloxacin administered via intravenous regional limb perfusion in dairy cows: evaluation of two different tourniquets Abstract Objectives This study evaluated synovial and systemic plasma pharmacokinetic variables of marbofloxacin after a single intravenous regional limb perfusion (IVRLP) perfor... |
PMC7357259 | core_pubmed_pmc | Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections | Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections Abstract Abstract Background In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day) has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data are available. We designed a pr... |
PMC12652054 | core_pubmed_pmc | Derivatization of Bufadienolides at Carbon-3 of the Steroid Core and Their Consequences for the Interaction with Na + ,K + -ATPase | Derivatization of Bufadienolides at Carbon-3 of the Steroid Core and Their Consequences for the Interaction with Na + ,K + -ATPase Abstract Abstract Bufadienolides exert broad-spectrum pharmacological activities relevant to cardiology and novel cancer treatments. Their efficacy, toxicity, and pharmacokinetic profiles a... |
PMC6986409 | core_pubmed_pmc | Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity | Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity Abstract Abstract Background Breast cancer is the leading cause of cancer death in women. Chemotherapy to inhibit the proliferation of cancer cells is considered to be the most important ... |
PMC10786692 | core_pubmed_pmc | Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation | Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation Abstract BACKGROUND P hase 1 study of ATR i nhibition al o ne or with radiation t herapy (PATRIOT) was a first-in-human phase I study of the oral ATR (ataxia telangiectasia and Rad3-related) inhibitor ceralasertib... |
PMC4792630 | core_pubmed_pmc | Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure | Therapeutic drug monitoring of enteric-coated mycophenolate sodium by limited sampling strategies is associated with a high rate of failure Abstract Abstract Background Therapeutic drug monitoring of mycophenolic acid (MPA) is usually performed with a limited sampling strategy (LSS), which relies on a limited number of... |
PMC9697349 | core_pubmed_pmc | Mouse Pharmacokinetics and In Vitro Metabolism of SH-11037 and SH-11008, Synthetic Homoisoflavonoids for Retinal Neovascularization | Mouse Pharmacokinetics and In Vitro Metabolism of SH-11037 and SH-11008, Synthetic Homoisoflavonoids for Retinal Neovascularization Abstract Cremastranone is a member of the homoisoflavanone family with anti-angiogenic activity in the eyes. SH-11037, a potent and selective synthetic homoisoflavonoid derived from cremas... |
PMC9290582 | core_pubmed_pmc | Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP‐5862, in patients with B‐cell malignancies and in healthy subjects using a population pharmacokinetic approach | Improved characterization of the pharmacokinetics of acalabrutinib and its pharmacologically active metabolite, ACP‐5862, in patients with B‐cell malignancies and in healthy subjects using a population pharmacokinetic approach Abstract Abstract This analysis aimed to describe the pharmacokinetics (PK) of acalabrutinib ... |
PMC3600329 | core_pubmed_pmc | A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment | A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment Abstract Abstract Chlorophenoxy compounds, particularly 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-chloro-2-methylphenoxy)acetic acid (MCPA), are amongst the most widely used herbicides in the Unit... |
PMC10425489 | core_pubmed_pmc | Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting | Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting Abstract Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients threatens therapeutic success. Model-i... |
PMC8213412 | core_pubmed_pmc | A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions | A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions Abstract Abstract The success of applications of physiologically‐based pharmacokinetic (PBPK) modeling in drug development and drug lab... |
PMC11670174 | core_pubmed_pmc | Pharmacokinetics, Pharmacodynamics and Bioavailability of ACM‐001.1 ( S ‐Pindolol Benzoate) in Healthy Volunteers | Pharmacokinetics, Pharmacodynamics and Bioavailability of ACM‐001.1 ( S ‐Pindolol Benzoate) in Healthy Volunteers Abstract ABSTRACT Background S ‐pindolol has metabolic effects of potential benefit in cancer cachexia: reduced catabolism through nonselective β‐blockade; increased anabolism through partial β2 receptor ag... |
PMC12529378 | core_pubmed_pmc | Synthetic Epoxy–Phenanthridine–Triazole Conjugates Induce Dual Redox Imbalance and Metabolic Remodeling in Breast Cancer Cells: An Integrative Mechanistic Evaluation from Synthesis to Mitochondrial Collapse | Synthetic Epoxy–Phenanthridine–Triazole Conjugates Induce Dual Redox Imbalance and Metabolic Remodeling in Breast Cancer Cells: An Integrative Mechanistic Evaluation from Synthesis to Mitochondrial Collapse Abstract Abstract Because of resistance and the absence of effective targeted therapies, breast cancer, particula... |
PMC11054330 | core_pubmed_pmc | Development of Mechanistic In Vitro–In Vivo Extrapolation to Support Bioequivalence Assessment of Long-Acting Injectables | Development of Mechanistic In Vitro–In Vivo Extrapolation to Support Bioequivalence Assessment of Long-Acting Injectables Abstract Abstract Long-acting injectable (LAI) formulations provide sustained drug release over an extended period ranging from weeks to several months to improve efficacy, safety, and compliance. N... |
PMC12107079 | core_pubmed_pmc | A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis | A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis Abstract Abstract Objectives The primary objective was the safety of s.c. immunoglobulin, IgPro20 (Hizentra, CSL Behring) in adults with dcSSc. Secondary objectives included pharmacokin... |
PMC6133080 | core_pubmed_pmc | Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects | Effects of Ketoconazole and Rifampicin on the Pharmacokinetics of Nintedanib in Healthy Subjects Abstract Abstract Background Nintedanib is a substrate for p-glycoprotein which can impact bioavailability. We investigated the effects of ketoconazole, a p-glycoprotein inhibitor, and rifampicin, a p-glycoprotein inducer, ... |
PMC12206899 | core_pubmed_pmc | A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli | A Comparison of in-vitro Pharmacokinetics and Pharmacodynamics of Branded and Its Locally Produced Cefuroxime Sodium Against Staphylococcus and Escherichia Escherichia coli Abstract Purpose To compare the in-vitro antibacterial effects of branded and its locally produced cefuroxime sodium against Staphylococcus ATCC292... |
PMC9298828 | core_pubmed_pmc | Bioequivalence and Pharmacokinetic Evaluation of 2 Pyrazinamide Formulations in Healthy Chinese Adults: A Single‐Dose, Open‐Label, Randomized‐Sequence, 2×2 Crossover Study | Bioequivalence and Pharmacokinetic Evaluation of 2 Pyrazinamide Formulations in Healthy Chinese Adults: A Single‐Dose, Open‐Label, Randomized‐Sequence, 2×2 Crossover Study Abstract Abstract A single‐dose, open‐label, randomized‐sequence, 2×2 crossover study was conducted in healthy Chinese adults, after fasting and pos... |
PMC9283366 | core_pubmed_pmc | Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients | Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients Abstract Purpose A population pharmacokinetic (popPK) model may be used to improve tacrolimus dosing and minimize under- and overexposure in kidney transplant recipients. It is unknown how body composition parameters relate ... |
PMC5186771 | core_pubmed_pmc | Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil | Optimized Cocktail Phenotyping Study Protocol Using Physiological Based Pharmacokinetic Modeling and In silico Assessment of Metabolic Drug–Drug Interactions Involving Modafinil Abstract In vivo cocktail pathway phenotyping (ICPP) is routinely used to assess the metabolic drug–drug interaction (mDDI) potential of new d... |
PMC5973963 | core_pubmed_pmc | A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types | A population pharmacokinetic model of cabozantinib in healthy volunteers and patients with various cancer types Abstract Abstract Purpose An integrated population pharmacokinetic (popPK) model was developed to describe the pharmacokinetics (PK) of tyrosine kinase inhibitor cabozantinib in healthy volunteers (HVs) and p... |
PMC12746395 | core_pubmed_pmc | Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches | Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches Abstract Abstract In silico pharmacokinetic–pharmacodynamic (PK–PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK–PD models capture the change in parasite count... |
PMC8215415 | core_pubmed_pmc | Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo | Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo Abstract Abstract State-of-the-art small interfering RNA (siRNA) therapeutics such as givosiran and fitusiran are constructed from three variable components: a fully-modified RNA core that conveys m... |
PMC6379869 | core_pubmed_pmc | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration Abstract Refractory hypothyroidism is caused by decreased gut absorption, increased metabolism, and poor compliance. Previous studies suggested that the weekly oral, suppository, or intra... |
PMC4542109 | core_pubmed_pmc | Optimising plasma levels of clozapine during metabolic interactions: a review and case report with adjunct rifampicin treatment | Optimising plasma levels of clozapine during metabolic interactions: a review and case report with adjunct rifampicin treatment Abstract Background Clozapine is the only licensed medication for treatment-resistant schizophrenia. The metabolism of clozapine is affected by multiple pharmacokinetic interactions, so the co... |
PMC12329490 | core_pubmed_pmc | Volatile anesthetics in the intensive care unit | Volatile anesthetics in the intensive care unit Abstract Abstract The use of volatile anesthetics as an alternative sedation modality in the intensive care unit (ICU) has gained traction over the last several years. Volatile agents such as sevo- flurane and isoflurane possess favorable pharmacokinetic and pharmacodynam... |
PMC4949011 | core_pubmed_pmc | A Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Lisdexamfetamine Dimesylate in Individuals With Normal and Impaired Renal Function | A Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Lisdexamfetamine Dimesylate in Individuals With Normal and Impaired Renal Function Abstract Supplemental Digital Content is Available in the Text. Background: Lisdexamfetamine (LDX) and d -amphetamine pharmacokinetics were assessed in ... |
PMC3480750 | core_pubmed_pmc | Determination and Estimation of Pharmacokinetic Profile of Caffeine in Form of Extract of Green Tea Leaves and its Analogy with Synthetic Form | Determination and Estimation of Pharmacokinetic Profile of Caffeine in Form of Extract of Green Tea Leaves and its Analogy with Synthetic Form Abstract Abstract The aim of the study was to formulate and investigate the pharmacokinetic parameters for the tablets of herbal extract of caffeine with comparison to synthetic... |
PMC8340548 | core_pubmed_pmc | Impact of Obesity in Critical Illness | Impact of Obesity in Critical Illness Abstract The prevalence of obesity is rising worldwide. Adipose tissue exerts anatomic and physiological effects with significant implications for critical illness. Changes in respiratory mechanics cause expiratory flow limitation, atelectasis, and V̇/Q̇ mismatch with resultant hyp... |
PMC8588213 | core_pubmed_pmc | Development of Natural Polysaccharide–Based Nanoparticles of Berberine to Enhance Oral Bioavailability: Formulation, Optimization, Ex Vivo, and In Vivo Assessment | Development of Natural Polysaccharide–Based Nanoparticles of Berberine to Enhance Oral Bioavailability: Formulation, Optimization, Ex Vivo, and In Vivo Assessment Abstract The phytogenous alkaloid berberine (BBR) has become a potential drug for the treatment of diabetes, hyperlipidemia, and cancer. However, its therape... |
PMC4594700 | core_pubmed_pmc | Opposite malaria and pregnancy effect on oral bioavailability of artesunate – a population pharmacokinetic evaluation | Opposite malaria and pregnancy effect on oral bioavailability of artesunate – a population pharmacokinetic evaluation Abstract Abstract Aim The aim was to compare the pharmacokinetic properties of artesunate and dihydroartemisinin in the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregn... |
PMC11873365 | core_pubmed_pmc | Population Pharmacokinetic and Exposure–Response Analyses for Ponatinib in the Phase 3 PhALLCON Study | Population Pharmacokinetic and Exposure–Response Analyses for Ponatinib in the Phase 3 PhALLCON Study Abstract ABSTRACT In March 2024, ponatinib received accelerated FDA approval for the treatment of newly diagnosed Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph + ALL) in combination with chemotherap... |
PMC7338319 | core_pubmed_pmc | Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection | Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection Abstract Background Treatment in bipolar disorder (BD) is commonly applied as a multimodal therapy based on decision algorithms that lack an integr... |
PMC11140628 | core_pubmed_pmc | The Safety, Tolerability, Pharmacokinetics, and Clinical Efficacy of the NLRX1 agonist NX-13 in Active Ulcerative Colitis: Results of a Phase 1b Study | The Safety, Tolerability, Pharmacokinetics, and Clinical Efficacy of the NLRX1 agonist NX-13 in Active Ulcerative Colitis: Results of a Phase 1b Study Abstract Abstract Background and Aims NX-13 activation of NLRX1 reduces intracellular reactive oxygen species and decreases inflammation in animal models of colitis. A p... |
PMC7241456 | core_pubmed_pmc | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning | Research progress of aconitine toxicity and forensic analysis of aconitine poisoning Abstract Abstract Chinese herbal medicines have been extensively used in China and other countries for centuries. Aconitine, a diterpenoid alkaloid extracted from Aconitum plants, has anti-inflammatory and analgesic activities, but can... |
PMC6539458 | core_pubmed_pmc | Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS | Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS Abstract Abstract Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of m... |
PMC9751437 | core_pubmed_pmc | Pharmacokinetics and efficacy of a novel long-acting bupivacaine formulation for cornual nerve block in calves | Pharmacokinetics and efficacy of a novel long-acting bupivacaine formulation for cornual nerve block in calves Abstract Local anesthetics are commonly used in farm animals to provide analgesia for painful procedures but can cause adverse effects at high systemic concentrations. The pharmacokinetics and efficacy of a lo... |
PMC10431053 | core_pubmed_pmc | Population pharmacokinetic analysis of the P2X3‐receptor antagonist gefapixant | Population pharmacokinetic analysis of the P2X3‐receptor antagonist gefapixant Abstract Abstract Gefapixant, a P2X3‐receptor antagonist, demonstrated objective and subjective efficacy in individuals with refractory or unexplained chronic cough. We report a population pharmacokinetic (PopPK) analysis that characterizes ... |
PMC10798361 | core_pubmed_pmc | Tunable control of B. infantis abundance and gut metabolites by co-administration of human milk oligosaccharides | Tunable control of B. infantis abundance and gut metabolites by co-administration of human milk oligosaccharides Abstract ABSTRACT Precision engineering of the gut microbiome holds promise as an effective therapeutic approach for diseases associated with a disruption in this microbial community. Engrafting a live bioth... |
PMC4926074 | core_pubmed_pmc | Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer | Pharmacokinetics in Mouse and Comparative Effects of Frondosides in Pancreatic Cancer Abstract The frondosides are triterpenoid glycosides from the Atlantic sea cucumber Cucumaria frondosa . Frondoside A inhibits growth, invasion, metastases and angiogenesis and induces apoptosis in diverse cancer types, including panc... |
PMC9261181 | core_pubmed_pmc | Rational identification of small molecules derived from 9,10-dihydrophenanthrene as potential inhibitors of 3CL pro enzyme for COVID-19 therapy: a computer-aided drug design approach | Rational identification of small molecules derived from 9,10-dihydrophenanthrene as potential inhibitors of 3CL pro enzyme for COVID-19 therapy: a computer-aided drug design approach Abstract Abstract Small molecules such as 9,10-dihydrophenanthrene derivatives have remarkable activity toward inhibition of SARS-CoV-2 3... |
PMC5896653 | core_pubmed_pmc | Pharmacokinetic equivalence study of nonsteroidal anti-inflammatory drug etoricoxib | Pharmacokinetic equivalence study of nonsteroidal anti-inflammatory drug etoricoxib Abstract Abstract Purpose The current study aimed to evaluate whether a generic product of etoricoxib 120 mg film-coated tablet (the test drug) was bioequivalent to the reference product (Arcoxia® film-coated tablet 120 mg). Methods Thi... |
PMC5159431 | core_pubmed_pmc | Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human | Prediction of Deoxypodophyllotoxin Disposition in Mouse, Rat, Monkey, and Dog by Physiologically Based Pharmacokinetic Model and the Extrapolation to Human Abstract Abstract Deoxypodophyllotoxin (DPT) is a potential anti-tumor candidate prior to its clinical phase. The aim of the study was to develop a physiologically ... |
PMC6590960 | core_pubmed_pmc | Analysis of the symptom response to esomeprazole 20 mg over days 1–4 of a 14-day course of treatment for frequent heartburn: results of two randomised controlled trials | Analysis of the symptom response to esomeprazole 20 mg over days 1–4 of a 14-day course of treatment for frequent heartburn: results of two randomised controlled trials Abstract Background Drug exposure and corresponding antisecretory effects increase over the first 4–5 days of esomeprazole treatment. To date, this eff... |
PMC11695982 | core_pubmed_pmc | Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial | Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial Abstract Abstract GT103 is a first-in-class, fully human, IgG3 monoclonal antibody targeting complement factor H that kills tumor cells and promotes anti-cancer immunity in preclinical models. We cond... |
PMC6656474 | core_pubmed_pmc | A Phase II Trial of Selinexor (KPT‐330) for Metastatic Triple‐Negative Breast Cancer | A Phase II Trial of Selinexor (KPT‐330) for Metastatic Triple‐Negative Breast Cancer Abstract Abstract Lessons Learned. Single‐agent selinexor has limited activity in heavily pretreated patients with metastatic triple‐negative breast cancer. Selinexor 60 mg by mouth twice weekly was generally well tolerated with a side... |
PMC7470163 | core_pubmed_pmc | Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats | Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats Abstract Abstract Context Rivaroxaban and ticagrelor are two common drugs for the treatment of atrial fibrillation and acute coronary syndrome. However, the drug–drug interaction between them is still unknown. Objective To investigate the effects of t... |
PMC8585621 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator PB-201 and its effects on the glucose excursion profile in drug-naïve Chinese patients with type 2 diabetes: a randomised controlled, crossover, single-centre phase 1 trial | Safety, tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator PB-201 and its effects on the glucose excursion profile in drug-naïve Chinese patients with type 2 diabetes: a randomised controlled, crossover, single-centre phase 1 trial Abstract Background PB-201, a partial, pancreas/liver-dua... |
PMC4217115 | core_pubmed_pmc | Ethanol Pharmacokinetics in Neonates and Infants | Ethanol Pharmacokinetics in Neonates and Infants Abstract Introduction Ethanol has been used for years in neonatal and infant liquid medications, yet the pharmacokinetics, pharmacodynamics, and safety of ethanol in this vulnerable population have not been well characterized. The purpose of this review is to raise aware... |
PMC10791220 | core_pubmed_pmc | Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release | Unexpectedly Prolonged Serotonin Syndrome and Fatal Complications Following a Massive Overdose of Paroxetine Controlled-Release Abstract Abstract Symptoms caused by a selective serotonin reuptake inhibitor (SSRI) overdose are often mild and can be managed with supportive care and close monitoring, even when complicated... |
PMC8008783 | core_pubmed_pmc | Network bioinformatics analysis provides insight into drug repurposing for COVID-19 | Network bioinformatics analysis provides insight into drug repurposing for COVID-19 Abstract Abstract The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 can yield treatments with known preclinic... |
PMC5800563 | core_pubmed_pmc | Shared and unshared exposure measurement error in occupational cohort studies and their effects on statistical inference in proportional hazards models | Shared and unshared exposure measurement error in occupational cohort studies and their effects on statistical inference in proportional hazards models Abstract Exposure measurement error represents one of the most important sources of uncertainty in epidemiology. When exposure uncertainty is not or only poorly account... |
PMC6235379 | core_pubmed_pmc | The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial | The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial Abstract Objectives Dexmedetomidine, a highly selective central α 2 -agonist, undergoes mainly biotransformation in the liver. The pharmacokinetics of dexmedetomidine were significantly affected by hepatic insufficiency. The... |
PMC6495008 | core_pubmed_pmc | Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B | Preclinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antifungal Activity of Liposomal Amphotericin B Abstract Abstract The improved safety profile and antifungal efficacy of liposomal amphotericin B (LAmB) compared to conventional amphotericin B deoxycholate (DAmB) is due to several factors includi... |
PMC9905677 | core_pubmed_pmc | Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins | Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins Abstract Although interactions of small molecular drugs with serum proteins have been widely studied from pharmacokinetic and pharmacodynamic perspectives, there have been few report... |
PMC10155203 | core_pubmed_pmc | Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo – In Vitro – In Silico Approach | Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo – In Vitro – In Silico Approach Abstract Encorafenib is a kinase inhibitor indicated for the treatment of patients with BRAF mutant melanoma and BRAF mutant metastatic colorectal cancer. To understand the effect of food and coadmini... |
PMC11763814 | core_pubmed_pmc | Tacrolimus- and Mycophenolate-Mediated Toxicity: Clinical Considerations and Options in Management of Post-Transplant Patients | Tacrolimus- and Mycophenolate-Mediated Toxicity: Clinical Considerations and Options in Management of Post-Transplant Patients Abstract Abstract Tacrolimus and mycophenolate are important immunosuppressive agents used to prevent organ rejection in post-transplant patients. While highly effective, their use is associate... |
PMC5605895 | core_pubmed_pmc | Medication dosing errors and associated factors in hospitalized pediatric patients from the South Area of the West Bank - Palestine | Medication dosing errors and associated factors in hospitalized pediatric patients from the South Area of the West Bank - Palestine Abstract Background Medication dosing errors are a significant global concern and can cause serious medical consequences for patients. Pediatric patients are at increased risk of dosing er... |
PMC9477921 | core_pubmed_pmc | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability Abstract Abstract Status epilepticus (SE) is an acute, life-threatening medical condition that requires immediate, effective therapy. Therefore, the acute care of prolonged ... |
PMC9499369 | core_pubmed_pmc | Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems? | Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems? Abstract Abstract Recent data show that young people, mainly due to the pressure of some risk factors or due to disrupt... |
PMC11084493 | core_pubmed_pmc | Evaluation of Target Attainment for Tobramycin in Children and Adults with Cystic Fibrosis | Evaluation of Target Attainment for Tobramycin in Children and Adults with Cystic Fibrosis Abstract Introduction: Patients with cystic fibrosis (CF) commonly experience pulmonary exacerbations, and it is recommended by the TOPIC study to treat this with tobramycin at a dose of 10 mg/kg once daily. The aim of this study... |
PMC3697037 | core_pubmed_pmc | Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose | Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose Abstract Several software tools are available that facilitate the use of the NONMEM software and extend its functionality. This tutorial shows how three commonly used and freely available tools, Pirana, PsN, and Xpose, form a tightly integ... |
PMC7893776 | core_pubmed_pmc | Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones | Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones Abstract Background The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting ... |
PMC5533163 | core_pubmed_pmc | Studies on Pharmacokinetic Drug Interaction Potential of Vinpocetine | Studies on Pharmacokinetic Drug Interaction Potential of Vinpocetine Abstract Abstract Background Vinpocetine, a semi-synthetic derivative of vincamine, is a popular dietary supplement used for the treatment of several central nervous system related disorders. Despite its wide use, no pharmacokinetic drug interaction s... |
PMC8788552 | core_pubmed_pmc | Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Peptides: When Is the Assessment of Certain Factors Warranted? | Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Peptides: When Is the Assessment of Certain Factors Warranted? Abstract Abstract Peptides are short chains of 2 to 50 amino acids (molecular weight of less than 10 kDa) linked together by peptide bonds. As therapeutic agents, peptides are of interest ... |
PMC7654909 | core_pubmed_pmc | Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model | Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pathogen of immense public health concern. Efforts to control the disease have only proven mildly successful,... |
PMC6801784 | core_pubmed_pmc | Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring? | Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring? Abstract Therapeutic drug monitoring is routinely performed to maintain optimal tacrolimus concentrations in kidney transplant recipients. Nonetheless, toxicity and rejection still occur within an acce... |
PMC4987691 | core_pubmed_pmc | Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children | Serum pharmacodynamic biomarkers for chronic corticosteroid treatment of children Abstract Corticosteroids are extensively used in pediatrics, yet the burden of side effects is significant. Availability of a simple, fast, and reliable biochemical read out of steroidal drug pharmacodynamics could enable a rapid and obje... |
PMC3137402 | core_pubmed_pmc | Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy | Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy Abstract Abstract Background: The objectives of this phase I study were to dete... |
PMC8607219 | core_pubmed_pmc | Evaluation of heparin infusion rates in patients with intravenous drug misuse | Evaluation of heparin infusion rates in patients with intravenous drug misuse Abstract Abstract To evaluate the hypothesis that patients with a history of intravenous drug misuse (IVDM) initiated on weight-based heparin infusions require higher than expected infusion rates to achieve therapeutic activated partial throm... |
PMC10674960 | core_pubmed_pmc | Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics | Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics Abstract Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer t... |
PMC7548281 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alirocumab in Healthy Chinese Subjects: A Randomized, Double-Blind, Placebo-Controlled, Ascending Single-Dose Study Abstract Background The addition of alirocumab (a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 [PCSK9]) ... |
PMC3370352 | core_pubmed_pmc | Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects | Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects Abstract AIM To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded v... |
PMC6153967 | core_pubmed_pmc | Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain | Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain Abstract Background ALZ-801 is an oral, small-molecule inhibitor of beta amyloid (Aβ) oligomer formation in clinical development for Alzheimer’s disease (AD).... |
PMC5548939 | core_pubmed_pmc | Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y 12 inhibitors | Perioperative management and monitoring of antiplatelet agents: a focused review on aspirin and P2Y 12 inhibitors Abstract Platelets play pivotal roles in hemostasis as well as pathological arterial thrombosis. The combination of aspirin and a P2Y 12 inhibitor has become the mainstay therapy in the ageing population wi... |
PMC11466258 | core_pubmed_pmc | From bench to babies – drug development for male subfertility | From bench to babies – drug development for male subfertility Abstract Abstract Infertility is estimated to affect more than 50 million couples around the world, with the male factor accounting for half of these cases, yet there is a notable absence of effective treatment options for men, other than in-vitro fertilisat... |
PMC4640432 | core_pubmed_pmc | In vitro - in vivo Pharmacokinetic correlation model for quality assurance of antiretroviral drugs | In vitro - in vivo Pharmacokinetic correlation model for quality assurance of antiretroviral drugs Abstract Abstract Introduction: The in vitro-in vivo pharmacokinetic correlation models (IVIVC) are a fundamental part of the drug discovery and development process. The ability to accurately predict the in vivo pharmacok... |
PMC5036603 | core_pubmed_pmc | Stealth, biocompatible monoolein-based lyotropic liquid crystalline nanoparticles for enhanced aloe-emodin delivery to breast cancer cells: in vitro and in vivo studies | Stealth, biocompatible monoolein-based lyotropic liquid crystalline nanoparticles for enhanced aloe-emodin delivery to breast cancer cells: in vitro and in vivo studies Abstract Recently, research has progressively highlighted on clues from conventional use of herbal medicines to introduce new anticancer drugs. Aloe-em... |
PMC12770982 | core_pubmed_pmc | Plasma cannabinoid concentrations and transference during long-term industrial hemp administration in cattle | Plasma cannabinoid concentrations and transference during long-term industrial hemp administration in cattle Abstract Abstract With recent legalization of industrial hemp (IH) production and increased interest in including IH and its byproducts in cattle feed, there is a need to establish the pharmacokinetic profiles o... |
PMC10697884 | core_pubmed_pmc | Efficacy of ceftiofur N -acyl homoserine lactonase niosome in the treatment of multi-resistant Klebsiella pneumoniae in broilers | Efficacy of ceftiofur N -acyl homoserine lactonase niosome in the treatment of multi-resistant Klebsiella pneumoniae in broilers Abstract In this study, the efficiency of the ceftiofur N -acyl homoserine lactonase niosome against multi-resistant Klebsiella pneumoniae in broilers was evaluated. Fifty-six K. pneumonia e ... |
PMC12950451 | core_pubmed_pmc | Pharmacokinetics and Renal Safety Evaluation of Colistin Methanesulfonate Sodium in Korean Healthy Male Volunteers: An Open-Label, Multiple-Dose Study | Pharmacokinetics and Renal Safety Evaluation of Colistin Methanesulfonate Sodium in Korean Healthy Male Volunteers: An Open-Label, Multiple-Dose Study Abstract Abstract Purpose The objective of this study was to evaluate the pharmacokinetics and renal safety of colistin methanesulfonate sodium (CMS) following single an... |
PMC11652804 | core_pubmed_pmc | Sex‐Dependent Effects of CYP2D6 on the Pharmacokinetics of Berberine in Humans | Sex‐Dependent Effects of CYP2D6 on the Pharmacokinetics of Berberine in Humans Abstract An over‐the‐counter product berberine (a major alkaloid in goldenseal) is a substrate of the uptake transporter OCT1 and the metabolizing enzyme CYP2D6. The two genes exhibit common functional polymorphisms. Approximately 9% of Euro... |
PMC10709251 | core_pubmed_pmc | A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab | A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab Abstract Abstract Aims/hypothesis We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokin... |
PMC10011747 | core_pubmed_pmc | Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer | Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer Abstract Summary Background Despite the advent of improved therapeutic options for advanced prostate cancer, the durability of clinical benefits is limited due to inevit... |
PMC11921695 | core_pubmed_pmc | Selumetinib in Combination with Anti Retroviral Therapy in HIV-associated Kaposi sarcoma (SCART): an open-label, multicentre, phase I/II trial | Selumetinib in Combination with Anti Retroviral Therapy in HIV-associated Kaposi sarcoma (SCART): an open-label, multicentre, phase I/II trial Abstract Abstract Background Kaposi sarcoma (KS) is the commonest HIV-associated malignancy. It is caused by co-infection with Kaposi sarcoma herpesvirus (KSHV), which upregulat... |
PMC6079620 | core_pubmed_pmc | Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA | Isolated Perfused Rat Livers to Quantify the Pharmacokinetics and Concentrations of Gd-BOPTA Abstract Abstract With recent advances in liver imaging, the estimation of liver concentrations is now possible following the injection of hepatobiliary contrast agents and radiotracers. However, how these images are generated ... |
PMC12299947 | core_pubmed_pmc | Comparative Bioavailability Study of Jaspine B: Impact of Nanoliposomal Drug Delivery System on Pharmacokinetics | Comparative Bioavailability Study of Jaspine B: Impact of Nanoliposomal Drug Delivery System on Pharmacokinetics Abstract Background/Objectives : Jaspine B, a synthetic analog of anhydrophytosphingosine, demonstrates significant anticancer activity; however, its clinical application is hindered by its poor oral bioavai... |
PMC9976450 | core_pubmed_pmc | Virtual screening, pharmacokinetic, and DFT studies of anticancer compounds as potential V600E-BRAF kinase inhibitors | Virtual screening, pharmacokinetic, and DFT studies of anticancer compounds as potential V600E-BRAF kinase inhibitors Abstract Objectives V600E-BRAF kinase is an essential therapeutic target in melanoma and other types of tumors. Because of its resistance to known inhibitors and the adverse effects of some identified i... |
PMC5609923 | core_pubmed_pmc | Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma: preparation, characterization, pharmacokinetics and tissue distribution | Bufalin-loaded bovine serum albumin nanoparticles demonstrated improved anti-tumor activity against hepatocellular carcinoma: preparation, characterization, pharmacokinetics and tissue distribution Abstract Objective To prepare and evaluate the liver-targeted drug delivery system of Bufalin with higher liver uptake and... |
PMC10326685 | core_pubmed_pmc | Application of physiologically based pharmacokinetic modeling to understand real‐world outcomes in patients receiving imatinib for chronic myeloid leukemia | Application of physiologically based pharmacokinetic modeling to understand real‐world outcomes in patients receiving imatinib for chronic myeloid leukemia Abstract Abstract We aimed to use physiologically based pharmacokinetic (PBPK) modeling and simulation to predict imatinib steady‐state plasma exposure in patients ... |
PMC12503793 | core_pubmed_pmc | Real-World Patient Outcomes on the Efficacy of Lanreotide Treatment for Neuroendocrine Tumors: The Influence of Body Mass Index, Body Surface Area, and Renal Function | Real-World Patient Outcomes on the Efficacy of Lanreotide Treatment for Neuroendocrine Tumors: The Influence of Body Mass Index, Body Surface Area, and Renal Function Abstract Abstract Introduction Lanreotide is an effective and safe first-line therapy to treat patients with a gastroenteropancreatic (GEP) neuroendocrin... |
PMC9516400 | core_pubmed_pmc | Meticulous parade on naringin respecting its pharmacological activities and novel formulations | Meticulous parade on naringin respecting its pharmacological activities and novel formulations Abstract Objective: Medicinal plants having antioxidant potential possess numerous constituents which are responsible for different beneficial effects and are used as an alternative resource of medicine to lessen diseases lin... |
PMC7293912 | core_pubmed_pmc | A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects | A Randomized, Crossover, Pharmacokinetic and Adhesion Performance Study of a Lidocaine Topical System 1.8% During Physical Activity and Heat Treatment in Healthy Subjects Abstract Purpose This study compares the pharmacokinetic (PK) profile, adhesion, and safety of lidocaine topical system 1.8%, a novel lidocaine topic... |
PMC4383362 | core_pubmed_pmc | A Phase I Trial to Evaluate the Multiple-Dose Safety and Antitumor Activity of Ursolic Acid Liposomes in Subjects with Advanced Solid Tumors | A Phase I Trial to Evaluate the Multiple-Dose Safety and Antitumor Activity of Ursolic Acid Liposomes in Subjects with Advanced Solid Tumors Abstract Abstract Ursolic acid liposome (UAL), a new antitumor drug, has potential therapeutic value. However, limited clinical data exists regarding multiple-dose safety, antitum... |
PMC12195795 | core_pubmed_pmc | Pharmacokinetic Equations Applied to Obtain New Topological Models in the Search of Antibacterial Compounds | Pharmacokinetic Equations Applied to Obtain New Topological Models in the Search of Antibacterial Compounds Abstract Abstract Background: QSAR (Quantitative Structure–Activity Relationships) methods have been the basis for the design of new molecules with a certain activity. The great advantage of QSAR methods is that ... |
PMC3594918 | core_pubmed_pmc | The pharmacokinetics and safety of an intraoperative bupivacaine-collagen implant (XaraColl ® ) for postoperative analgesia in women following total abdominal hysterectomy | The pharmacokinetics and safety of an intraoperative bupivacaine-collagen implant (XaraColl ® ) for postoperative analgesia in women following total abdominal hysterectomy Abstract Background XaraColl ® , a collagen-based intraoperative implant that delivers bupivacaine to the site of surgical trauma, is under developm... |
PMC12320182 | core_pubmed_pmc | Dual-targeted N-PMI plus @CA nanoplatform for concurrent MDM2 and β-catenin inhibition in p53 wild-type lung adenocarcinoma | Dual-targeted N-PMI plus @CA nanoplatform for concurrent MDM2 and β-catenin inhibition in p53 wild-type lung adenocarcinoma Abstract Abstract Lung adenocarcinoma (LUAD) harboring wild-type p53 remains therapeutically challenging because of the oncogenic MDM2-driven suppression of p53 activity and compensatory activatio... |
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