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PMC8016336 | core_pubmed_pmc | Impact of initial vancomycin pharmacokinetic/pharmacodynamic parameters on the clinical and microbiological outcomes of methicillin-resistant Staphylococcus aureus bacteremia in children | Impact of initial vancomycin pharmacokinetic/pharmacodynamic parameters on the clinical and microbiological outcomes of methicillin-resistant Staphylococcus aureus bacteremia in children Abstract Abstract Optimal vancomycin exposure is important to minimize treatment failure of methicillin-resistant Staphylococcus aure... |
PMC4869592 | core_pubmed_pmc | Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB | Serial image analysis of Mycobacterium tuberculosis colony growth reveals a persistent subpopulation in sputum during treatment of pulmonary TB Abstract Summary Faster elimination of drug tolerant ‘persister’ bacteria may shorten treatment of tuberculosis (TB) but no method exists to quantify persisters in clinical sam... |
PMC10052210 | core_pubmed_pmc | Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier | Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier Abstract Extracellular vesicles are lipid bilayer-delimited nanoparticles excreted into the extracellular space by all cells. They carry a cargo rich in proteins, lipids and DNA, as well as a full complement of RNA species, whic... |
PMC6360659 | core_pubmed_pmc | Susceptibility breakpoint for Danofloxacin against swine Escherichia coli | Susceptibility breakpoint for Danofloxacin against swine Escherichia coli Abstract Abstract Background Improper use of antimicrobials results in poor treatment and severe bacterial resistance. Breakpoints are routinely used in the clinical laboratory setting to guide clinical decision making. Therefore, the objective o... |
PMC10146281 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects | Pharmacokinetic and Pharmacodynamic Characteristics of Pelubiprofen Tromethamine vs. Pelubiprofen in Healthy Subjects Abstract Compared to pelubiprofen, a cyclooxygenase-2-selective inhibitor, pelubiprofen tromethamine has been reported to exhibit improved solubility and absorption. Pelubiprofen tromethamine combines t... |
PMC4418713 | core_pubmed_pmc | In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene | In Vitro and In Vivo Evaluations of PLGA Microspheres Containing Nalmefene Abstract Abstract Poor patient compliance, untoward reactions and unstable blood drug levels after the bolus administration are impeding the pharmacotherapy for insobriety. A long-acting preparation may address these limitations. The aim of this... |
PMC10583261 | core_pubmed_pmc | Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC‐92480), a novel cereblon E3 ligase modulator | Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC‐92480), a novel cereblon E3 ligase modulator Abstract Abstract Mezigdomide is a novel cereblon E3 ligase modulator (CELMoD) agent with enhanced autonomous cell‐killing activity in multiple myeloma (MM) cells, and promis... |
PMC6284848 | core_pubmed_pmc | In Vitro and In Vivo Evaluation of Different Solid Dosage Forms Containing Captopril | In Vitro and In Vivo Evaluation of Different Solid Dosage Forms Containing Captopril Abstract Aim. Comparison of Captopril generic formulations on the Romanian market with the reference formulation Capoten (Bristol Myers Squibb), in terms of in vitro release kinetics of active substance and in vivo pharmacokinetics. Ma... |
PMC8727892 | core_pubmed_pmc | Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity | Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity Abstract Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal ... |
PMC12823442 | core_pubmed_pmc | The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome | The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome Abstract VOWST (VOWST oral spores, VOS; fecal microbiota spores, live-brpk, formerly SER-109) is an FDA-approved, orally administered consortium of purified Firmicutes spores developed to prevent recurrent Clostridioides difficile ... |
PMC5768983 | core_pubmed_pmc | Single‐dose pharmacokinetic study comparing the pharmacokinetics of recombinant human chorionic gonadotropin in healthy Japanese and Caucasian women and recombinant human chorionic gonadotropin and urinary human chorionic gonadotropin in healthy Japanese women | Single‐dose pharmacokinetic study comparing the pharmacokinetics of recombinant human chorionic gonadotropin in healthy Japanese and Caucasian women and recombinant human chorionic gonadotropin and urinary human chorionic gonadotropin in healthy Japanese women Abstract Abstract Purpose Recombinant hCG (r‐hCG) was appro... |
PMC4857956 | core_pubmed_pmc | Pharmacokinetics of Total Thyroxine after Repeated Oral Administration of Levothyroxine Solution and its Clinical Efficacy in Hypothyroid Dogs | Pharmacokinetics of Total Thyroxine after Repeated Oral Administration of Levothyroxine Solution and its Clinical Efficacy in Hypothyroid Dogs Abstract Abstract Background Oral levothyroxine ( l ‐T 4 ) supplementation is commonly used to treat hypothyroid dogs. Objectives Investigate the plasma profile and pharmacokine... |
PMC12436669 | core_pubmed_pmc | The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants | The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants Abstract ABSTRACT This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (f... |
PMC6090208 | core_pubmed_pmc | Association of Variability and Pharmacogenomics With Bioequivalence of Gefitinib in Healthy Male Subjects | Association of Variability and Pharmacogenomics With Bioequivalence of Gefitinib in Healthy Male Subjects Abstract Abstract Objective: The aim of the study was to explore the association of pharmacokinetic variability and pharmacogenomics with the bioequivalence of orally administered gefitinib (Iressa®, AstraZeneca) p... |
PMC5595955 | core_pubmed_pmc | Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose‐ranging study | Treatment of spontaneous preterm labour with retosiban: a phase II pilot dose‐ranging study Abstract Abstract Aims The aims of the present study were to investigate the maternal, fetal and neonatal safety and tolerability, pharmacodynamics and pharmacokinetics of intravenous (IV) retosiban in pregnant women with sponta... |
PMC9616544 | core_pubmed_pmc | Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies | Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies Abstract Abstract Background Patients with haematological malignancies frequently endure neutropenia and gastrointestinal (GI)-mucositis after high-dose che... |
PMC2965867 | core_pubmed_pmc | A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients | A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients Abstract Background: Human hepatocellular carcinoma (HCC) cells are largely deficient of argininosuccinate synthetase and thus auxotrophic for arginine. This study aims to investigate the efficac... |
PMC12013723 | core_pubmed_pmc | Pharmacokinetics of cannabidiol, (-)- trans -Δ 9 -tetrahydrocannabinol, and their oxidative metabolites after intravenous and oral administration of a cannabidiol-dominant full-spectrum hemp product to beagle dogs | Pharmacokinetics of cannabidiol, (-)- trans -Δ 9 -tetrahydrocannabinol, and their oxidative metabolites after intravenous and oral administration of a cannabidiol-dominant full-spectrum hemp product to beagle dogs Abstract Abstract Introduction This study investigated the pharmacokinetics, safety, and tolerability of a... |
PMC9891774 | core_pubmed_pmc | Prevalence and factors associated with potentially inappropriate medication and medication complexity for older adults in the emergency department of a secondary teaching hospital in Indonesia | Prevalence and factors associated with potentially inappropriate medication and medication complexity for older adults in the emergency department of a secondary teaching hospital in Indonesia Abstract Abstract Background: Older adults experience progressive decline in various organs and changes in pharmacokinetics and... |
PMC9070820 | core_pubmed_pmc | Pharmacokinetics and Safety of 3 Months of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Pregnant Women | Pharmacokinetics and Safety of 3 Months of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention in Pregnant Women Abstract Abstract Background Pregnancy increases the risk of tuberculosis and its complications. A 3-month regimen of weekly isoniazid and rifapentine (3HP) is safe and effective for tuberculosis pr... |
PMC8645681 | core_pubmed_pmc | Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib | Application of Physiologically Based Pharmacokinetic Modeling to Evaluate the Drug–Drug and Drug–Disease Interactions of Apatinib Abstract Abstract Aim: Apatinib is an orally administered vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitors approved for the treatment of advanced gastric adenocar... |
PMC10975475 | core_pubmed_pmc | Dose Prediction and Pharmacokinetic Simulation of XZP-5610, a Small Molecule for NASH Therapy, Using Allometric Scaling and Physiologically Based Pharmacokinetic Models | Dose Prediction and Pharmacokinetic Simulation of XZP-5610, a Small Molecule for NASH Therapy, Using Allometric Scaling and Physiologically Based Pharmacokinetic Models Abstract Abstract The objectives of this study were to support dose selection of a novel FXR agonist XZP-5610 in first-in-human (FIH) trials and to pre... |
PMC9655233 | core_pubmed_pmc | Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from Ligusticum sinense Oliv.cv. Chaxiong | Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from Ligusticum sinense Oliv.cv. Chaxiong Abstract Abstract Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and ... |
PMC4863542 | core_pubmed_pmc | Effect of anions or foods on absolute bioavailability of calcium from calcium salts in mice by pharmacokinetics | Effect of anions or foods on absolute bioavailability of calcium from calcium salts in mice by pharmacokinetics Abstract Abstract We studied the absolute bioavailability of calcium from calcium L-lactate in mice using pharmacokinetics, and reviewed the absolute bioavailability of calcium from three other calcium salts ... |
PMC9312211 | core_pubmed_pmc | Association between Augmented Renal Clearance and Inadequate Vancomycin Pharmacokinetic/Pharmacodynamic Targets in Chinese Adult Patients: A Prospective Observational Study | Association between Augmented Renal Clearance and Inadequate Vancomycin Pharmacokinetic/Pharmacodynamic Targets in Chinese Adult Patients: A Prospective Observational Study Abstract Abstract This study aimed to examine the risk factors of augmented renal clearance (ARC) and the association between ARC and vancomycin ph... |
PMC7545999 | core_pubmed_pmc | Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors | Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors Abstract Background: There has been growing interest in nanobubbles for their potential to extend bubble-mediated ultrasound approaches beyond that of their larger microbubble counterparts. In particular, the smaller scale o... |
PMC6939174 | core_pubmed_pmc | Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children | Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children Abstract Abstract Background Montelukast, a potent oral selective leukotriene-receptor antagonist, inhibits the action of cysteinyl-leukotriene in patients with asthma. Although pharmacokinetic studies of montelukast have been... |
PMC9805977 | core_pubmed_pmc | Formulation of metoclopramide HCl gastroretentive film and in vitro - in silico prediction using Gastroplus® PBPK software | Formulation of metoclopramide HCl gastroretentive film and in vitro - in silico prediction using Gastroplus® PBPK software Abstract Abstract The new trends in pharmaceutical studies focus on targeting drug delivery and computer software that help in the body environment simulation, such as Gastroplus® software. The int... |
PMC4151019 | core_pubmed_pmc | Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots | Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots Abstract The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and P-glycoprotein (P-gp) using a cocktail approach. Ten voluntee... |
PMC12718062 | core_pubmed_pmc | VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results | VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results Abstract Abstract Background VH3810109 (N6LS) is a CD4-binding site antibody with broad and potent neutralizing activity in vitro. Here, we present efficacy, safe... |
PMC11251612 | core_pubmed_pmc | Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial | Safety and pharmacokinetics of VRC07-523LS administered via different routes and doses (HVTN 127/HPTN 087): A Phase I randomized clinical trial Abstract Abstract Background Broadly neutralizing antibodies (bnAbs) are a promising approach for HIV-1 prevention. In the Antibody Mediated Prevention (AMP) trials, a CD4-bind... |
PMC5170492 | core_pubmed_pmc | Parasite Clearance and Artemether Pharmacokinetics Parameters Over the Course of Artemether-Lumefantrine Treatment for Malaria in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Ugandan Children | Parasite Clearance and Artemether Pharmacokinetics Parameters Over the Course of Artemether-Lumefantrine Treatment for Malaria in Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Ugandan Children Abstract Abstract Background. Artemisinins are primarily responsible for initial parasite clearance. Antimalar... |
PMC12317701 | core_pubmed_pmc | Recent Advances in Nanozymes for the Treatment of Atherosclerosis | Recent Advances in Nanozymes for the Treatment of Atherosclerosis Abstract Abstract Atherosclerosis (AS) is a complex, multifactorial cardiovascular disease characterized by lipid accumulation, chronic inflammation, oxidative stress, and endothelial dysfunction. Conventional therapies, including lipid-lowering and anti... |
PMC9283748 | core_pubmed_pmc | A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK‐1654 in healthy Japanese adults | A phase I study to evaluate safety, pharmacokinetics, and pharmacodynamics of respiratory syncytial virus neutralizing monoclonal antibody MK‐1654 in healthy Japanese adults Abstract Abstract Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among all infants worldwide and rema... |
PMC11602960 | core_pubmed_pmc | Exposure–response modelling of osimertinib in patients with non‐small cell lung cancer | Exposure–response modelling of osimertinib in patients with non‐small cell lung cancer Abstract Aims Osimertinib is a third‐generation, irreversible, central nervous system‐active, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with efficacy in EGFR‐mutated non‐small cell lung cancer (NSCLC). W... |
PMC6118294 | core_pubmed_pmc | Quantitative Prediction of OATP‐Mediated Drug‐Drug Interactions With Model‐Based Analysis of Endogenous Biomarker Kinetics | Quantitative Prediction of OATP‐Mediated Drug‐Drug Interactions With Model‐Based Analysis of Endogenous Biomarker Kinetics Abstract Quantitative prediction of the magnitude of transporter‐mediated clinical drug‐drug interactions (DDIs) solely from in vitro inhibition data remains challenging. The objective of the prese... |
PMC7496954 | core_pubmed_pmc | Absorption, distribution, metabolism and excretion of molidustat in healthy participants | Absorption, distribution, metabolism and excretion of molidustat in healthy participants Abstract Abstract The absorption, distribution, metabolism and excretion of molidustat were investigated in healthy male participants. In study 1, a mass balance study, radiolabelled molidustat 25 mg (3.57 MBq) was administered as ... |
PMC12735975 | core_pubmed_pmc | Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively | Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively Abstract Abstract Background/Objectives : Metabolic enzymes are crucial for the detoxification of exogenously administered dr... |
PMC11087235 | core_pubmed_pmc | Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury | Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury Abstract Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercapr... |
PMC7212907 | core_pubmed_pmc | Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine | Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine Abstract Abstract Background Hundreds of systemic chemotherapy trials in diffuse intrinsic pontine glioma (DIPG) have not improved survival, potentially due to lack of intratumoral penetration, which has not p... |
PMC10583237 | core_pubmed_pmc | Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B | Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B Abstract Abstract The orally available anti‐hepatitis C virus (HCV) drug simeprevir exhibits nonlinear pharmacokinetics at the clinical doses due to saturation of cytochro... |
PMC12009141 | core_pubmed_pmc | Drug-Drug Interactions Leading to Tacrolimus Toxicity in a Renal Transplant Patient With COVID-19: The Role of Paxlovid and the Mitigating Use of Phenytoin | Drug-Drug Interactions Leading to Tacrolimus Toxicity in a Renal Transplant Patient With COVID-19: The Role of Paxlovid and the Mitigating Use of Phenytoin Abstract Abstract Tacrolimus, a calcineurin inhibitor widely used in transplant immunosuppression, requires careful monitoring due to its narrow therapeutic index a... |
PMC3065800 | core_pubmed_pmc | Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles | Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles Abstract Abstract The purpose of this study was to use solid lipid nanoparticles (SLN) to improve the pharmacological activity of ofloxacin. Ofloxacin-loaded SLN were prepared using palmitic acid as lipid matrix and poly vinyl alcoho... |
PMC10616546 | core_pubmed_pmc | Pharmacokinetic profiles and egg residue patterns of levamisole in laying hens at two dosing rates and two routes of administration | Pharmacokinetic profiles and egg residue patterns of levamisole in laying hens at two dosing rates and two routes of administration Abstract The levamisole maximum residue limit for edible fat, kidney, and muscle of chickens is 0.01 mg/kg. However, no maximum residue limit has been established for eggs. In the present ... |
PMC10990730 | core_pubmed_pmc | Comparison of the pharmacokinetic characteristics and bioequivalence between two nanosuspension formulations of megestrol acetate in healthy Korean male subjects | Comparison of the pharmacokinetic characteristics and bioequivalence between two nanosuspension formulations of megestrol acetate in healthy Korean male subjects Abstract Abstract Megestrol is commonly used to address appetite loss, cachexia, and significant weight loss in cancer or acquired immune deficiency syndrome ... |
PMC8408929 | core_pubmed_pmc | Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation | Influence of osmolality on gastrointestinal fluid volume and drug absorption: potential impact on oral salt supplementation Abstract Abstract Background The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most frequent cause of hyponatremia in patients with cerebrovascular disease, and is oft... |
PMC3523151 | core_pubmed_pmc | Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats | Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats Abstract Abstract Paullinia cupana is used in weight-loss programs as a constituent of medicinal/dietary supplements. This study aimed to assess a potential herb-drug interaction among a standardized (certifie... |
PMC8313742 | core_pubmed_pmc | KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats | KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats Abstract Objective Dual amylin and calcitonin receptor agonists (DACRAs) are novel therapeutic agents that not only improve insulin sensitivity but also work as an adjunct to... |
PMC12252992 | core_pubmed_pmc | Breathing hazards: Perspective on the adverse health effects of organophosphate flame retardants | Breathing hazards: Perspective on the adverse health effects of organophosphate flame retardants Abstract Since the 1970s, flame retardants have been applied to consumer and industrial products to prevent combustion and the spread of fires, with polybrominated diphenyl ethers (PBDEs) being the most prevalent. However, ... |
PMC9019273 | core_pubmed_pmc | Liposome co-encapsulation of anti-cancer agents for pharmacological optimization of nanomedicine-based combination chemotherapy | Liposome co-encapsulation of anti-cancer agents for pharmacological optimization of nanomedicine-based combination chemotherapy Abstract Abstract Aim : Co-encapsulation of anti-cancer agents in pegylated liposomes may provide an effective tool to maximize efficacy of combined drug therapy by taking advantage of the lon... |
PMC12278049 | core_pubmed_pmc | Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial | Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial Abstract Background Despite the high prevalence of social and performance anxiety, current treatments do not meet the full needs of patients. Deve... |
PMC8071222 | core_pubmed_pmc | Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates | Design, Synthesis, and Antimicrobial Activity of Certain New Indole-1,2,4 Triazole Conjugates Abstract The increasing prevalence of microbial infections and the emergence of resistance to the currently available antimicrobial drugs urged the development of potent new chemical entities with eminent pharmacokinetic and/o... |
PMC7780989 | core_pubmed_pmc | Effect of Inhibiting Tumor Angiogenesis After Embolization in the Treatment of HCC with Apatinib-Loaded p( N -Isopropyl-Acrylamide- co -Butyl Methyl Acrylate) Temperature-Sensitive Nanogel | Effect of Inhibiting Tumor Angiogenesis After Embolization in the Treatment of HCC with Apatinib-Loaded p( N -Isopropyl-Acrylamide- co -Butyl Methyl Acrylate) Temperature-Sensitive Nanogel Abstract Abstract Background Transcatheter arterial embolization (TAE) is widely used in hepatocellular carcinoma (HCC) therapy. Tu... |
PMC9227859 | core_pubmed_pmc | Pharmacogenetic Analysis of Voriconazole Treatment in Children | Pharmacogenetic Analysis of Voriconazole Treatment in Children Abstract Abstract Voriconazole is among the first-line antifungal drugs to treat invasive fungal infections in children and known for its pronounced inter- and intraindividual pharmacokinetic variability. Polymorphisms in genes involved in the metabolism an... |
PMC11390544 | core_pubmed_pmc | Association of combined lead, cadmium, and mercury with systemic inflammation | Association of combined lead, cadmium, and mercury with systemic inflammation Abstract Background Exposure to environmental metals has been increasingly associated with systemic inflammation, which is implicated in the pathogenesis of various chronic diseases, including those with neurodegenerative aspects. However, th... |
PMC9676785 | core_pubmed_pmc | Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations | Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations Abstract Background and Objectives Prediction of antimicrobial target-site pharmacokinetics is of relevance to optimize treatment with antimicrobial agents. A physiologically based pharmaco... |
PMC11055451 | core_pubmed_pmc | Enabling a novel solvent method on Albendazole solid dispersion to improve the in vivo bioavailability | Enabling a novel solvent method on Albendazole solid dispersion to improve the in vivo bioavailability Abstract Abstract Albendazole, a vital medication endorsed by the World Health Organization for combating parasitic infections, encounters a challenge stemming from its low solubility, significantly impeding absorptio... |
PMC9291887 | core_pubmed_pmc | Population Pharmacokinetics of Viloxazine Extended‐Release Capsules in Pediatric Subjects With Attention Deficit/Hyperactivity Disorder | Population Pharmacokinetics of Viloxazine Extended‐Release Capsules in Pediatric Subjects With Attention Deficit/Hyperactivity Disorder Abstract Abstract Viloxazine extended‐release capsules (viloxazine ER; Qelbree) is a novel nonstimulant, recently approved by the US Food and Drug Administration for the treatment of A... |
PMC11369465 | core_pubmed_pmc | QSAR, molecular docking, and pharmacokinetic analysis of thiosemicarbazone-indole compounds targeting prostate cancer cells | QSAR, molecular docking, and pharmacokinetic analysis of thiosemicarbazone-indole compounds targeting prostate cancer cells Abstract Abstract Objectives By 2030, prostate cancer is estimated to account for 1.7 million new cases and 499,000 deaths. The objectives of this research were to create a model revealing the act... |
PMC11095706 | core_pubmed_pmc | Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment | Machine-learning and mechanistic modeling of metastatic breast cancer after neoadjuvant treatment Abstract Abstract Clinical trials involving systemic neoadjuvant treatments in breast cancer aim to shrink tumors before surgery while simultaneously allowing for controlled evaluation of biomarkers, toxicity, and suppress... |
PMC10857990 | core_pubmed_pmc | A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic | A novel nanobody-based immunocytokine of a mutant interleukin-2 as a potential cancer therapeutic Abstract Abstract The immunotherapeutic application of interleukin-2 (IL-2) in cancer treatment is limited by its off-target effects on different cell populations and insufficient activation of anti-tumor effector cells at... |
PMC9145981 | core_pubmed_pmc | Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection | Fluorescent Labeling of Polymannuronic Acid and Its Distribution in Mice by Tail Vein Injection Abstract Polymannuronic acid (PM) possesses more pharmacological activities than sodium alginate, but there have been few studies on its absorption mechanism, tissue distribution, and pharmacokinetics. Studies of pharmacokin... |
PMC7959684 | core_pubmed_pmc | Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An update | Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An update Abstract Abstract The review summarizes chloroquine (CQ) and its safer derivative hydroxychloroquine (HCQ) and its utility in Covid-19. Recently this well-established drug made its way back to the headlines during the SARS-CoV-2 pande... |
PMC8584095 | core_pubmed_pmc | Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature) | Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature) Abstract Abstract Pharmacogenomic studies in epilepsy are justified by the high prevalence rate of this disease and the high cost of its treatment, frequent drug resistance, different response to the drug, the possibility of using reliable methods to as... |
PMC6325983 | core_pubmed_pmc | Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II | Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II Abstract Background Alirocumab, a human monoc... |
PMC11424760 | core_pubmed_pmc | Molecular Docking and Pharmacokinetics Prediction of Piperine and Capsaicin as Human Pancreatic Lipase Inhibitors: An In Silico Study | Molecular Docking and Pharmacokinetics Prediction of Piperine and Capsaicin as Human Pancreatic Lipase Inhibitors: An In Silico Study Abstract Abstract Introduction Obesity is a complex multifaceted disease, characterized by excessive body fat accumulation. It is a major public health concern globally, affecting indivi... |
PMC11504268 | core_pubmed_pmc | Pharmacokinetics of Vancomycin in Healthy Korean Volunteers and Monte Carlo Simulations to Explore Optimal Dosage Regimens in Patients with Normal Renal Function | Pharmacokinetics of Vancomycin in Healthy Korean Volunteers and Monte Carlo Simulations to Explore Optimal Dosage Regimens in Patients with Normal Renal Function Abstract Abstract Background/Objectives : To date, population pharmacokinetic (PK) studies of vancomycin on healthy Korean adults have not been conducted. Thi... |
PMC10040578 | core_pubmed_pmc | The mechanism of action of paeoniae radix rubra–angelicae sinensis radix drug pair in the treatment of rheumatoid arthritis through PI3K/AKT/NF-κB signaling pathway | The mechanism of action of paeoniae radix rubra–angelicae sinensis radix drug pair in the treatment of rheumatoid arthritis through PI3K/AKT/NF-κB signaling pathway Abstract Objective: To investigate the effects and mechanisms of Paeoniae radix rubra–Angelicae sinensis radix (P-A) drug pair in the treatment of rheumato... |
PMC6636523 | core_pubmed_pmc | Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis | Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis Abstract This study aims to predict the active ingredients, potential targets, signaling pathways and investigate the “ingredient-target-pathway” mech... |
PMC4725634 | core_pubmed_pmc | Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility | Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility Abstract Abstract The health care costs associated with prescription drugs are enormous, particularly in patients with polypharmacy (taking more than five prescription medications), a... |
PMC9932361 | core_pubmed_pmc | An intra‐articular injectable phospholipids‐based gel for the treatment of rheumatoid arthritis | An intra‐articular injectable phospholipids‐based gel for the treatment of rheumatoid arthritis Abstract Rheumatoid arthritis (RA) is a chronic inflammatory and destructive arthropathy with a high deformity rate. Despite numerous studies and clinical trials, no curative treatment is available for large weight-bearing j... |
PMC12044326 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions of Soticlestat as a Victim of CYP Induction and Inhibition, and as a Perpetrator of CYP and P–Glycoprotein Inhibition | Physiologically Based Pharmacokinetic Modeling to Predict Drug–Drug Interactions of Soticlestat as a Victim of CYP Induction and Inhibition, and as a Perpetrator of CYP and P–Glycoprotein Inhibition Abstract Abstract Soticlestat (TAK‐935) is a cholesterol 24‐hydroxylase inhibitor. A physiologically‐based pharmacokineti... |
PMC10879530 | core_pubmed_pmc | Comparative physicochemical and structural characterisation studies establish high biosimilarity between BGL-ASP and reference insulin aspart | Comparative physicochemical and structural characterisation studies establish high biosimilarity between BGL-ASP and reference insulin aspart Abstract Abstract Biosimilar insulin analogues are increasing market access for diabetic patients globally. Scientific establishment of biosimilarity is cornerstone of this key c... |
PMC12503259 | core_pubmed_pmc | Establishment of an in vivo analytical method for detecting total anti-UFH activity and pharmacokinetic study in PS and R15 in rats | Establishment of an in vivo analytical method for detecting total anti-UFH activity and pharmacokinetic study in PS and R15 in rats Abstract Protamine sulfate (PS), the only U.S. Food and Drug Administration (FDA)-approved heparin antagonist, is encumbered by several drawbacks. R15, a synthetic polyarginine peptide, ha... |
PMC6045908 | core_pubmed_pmc | Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma | Montmorillonite/chitosan nanoparticles as a novel controlled-release topical ophthalmic delivery system for the treatment of glaucoma Abstract Abstract Background To date, the rapid clearance from ocular surface has been a huge obstacle for using eye drops to treat glaucoma, since it has led to the short preocular resi... |
PMC6769327 | core_pubmed_pmc | Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents | Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents Abstract Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for vete... |
PMC4981171 | core_pubmed_pmc | Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique | Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique Abstract Abstract The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME) for oral administration to improve its solubility and enhance its bioavailability. Based on a solubility stu... |
PMC8309196 | core_pubmed_pmc | Radioimmunotheranostic Pair Based on the Anti-HER2 Monoclonal Antibody: Influence of Chelating Agents and Radionuclides on Biological Properties | Radioimmunotheranostic Pair Based on the Anti-HER2 Monoclonal Antibody: Influence of Chelating Agents and Radionuclides on Biological Properties Abstract The oncogene HER2 is an important molecular target in oncology because it is associated with aggressive disease and the worst prognosis. The development of non-invasi... |
PMC6045477 | core_pubmed_pmc | Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6 | Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6 Abstract Abstract The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp( N Me)K) was decorated with different chel... |
PMC8960636 | core_pubmed_pmc | Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved | Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved Abstract Abstract Liver steatosis is a key pathology in non-alcoholic or metabolic associated fatty liver disease. Though largely ignored for decades it is currently becoming the focus of re... |
PMC6332349 | core_pubmed_pmc | Simultaneous Determination of Eight Ginsenosides in Rat Plasma by Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry: Application to Their Pharmacokinetics | Simultaneous Determination of Eight Ginsenosides in Rat Plasma by Liquid Chromatography–Electrospray Ionization Tandem Mass Spectrometry: Application to Their Pharmacokinetics Abstract Abstract A high-performance liquid chromatography–electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) method was successful... |
PMC9633546 | core_pubmed_pmc | Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance | Redesign of Rifamycin Antibiotics to Overcome ADP‐Ribosylation‐Mediated Resistance Abstract Abstract Rifamycin antibiotics are a valuable class of antimicrobials for treating infections by mycobacteria and other persistent bacteria owing to their potent bactericidal activity against replicating and non‐replicating path... |
PMC3641071 | core_pubmed_pmc | Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer | Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer Abstract Introduction Breast cancer brain metastases (BCBM) are a challenging consequence of advanced BC. Nanoparticle agents, including liposomes, have shown enhanced delivery to solid tumors and brain. We compar... |
PMC12931065 | core_pubmed_pmc | Green evaluation of human plasma levels of metformin, linagliptin, and empagliflozin using HPLC and HPTLC methods: a pharmacokinetic study | Green evaluation of human plasma levels of metformin, linagliptin, and empagliflozin using HPLC and HPTLC methods: a pharmacokinetic study Abstract Two simple, rapid, cost-effective, and environmentally friendly chromatographic methods were developed and validated for the simultaneous determination of metformin (MEF), ... |
PMC6771554 | core_pubmed_pmc | Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054 | Randomized phase I clinical trial of anti–α‐synuclein antibody BIIB054 Abstract Abstract Background Pathological and genetic evidence implicates toxic effects of aggregated α‐synuclein in the pathophysiology of neuronal dysfunction and degeneration in Parkinson's disease. Immunotherapy targeting aggregated α‐synuclein ... |
PMC6994638 | core_pubmed_pmc | Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol’s pharmacokinetics: a prospective cohort study | Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol’s pharmacokinetics: a prospective cohort study Abstract Abstract Some previous studies have indicated that valproate (VPA) might change the pharmacokinetics and enhance the effects of propofol. W... |
PMC6788505 | core_pubmed_pmc | Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01495k | Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body † †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc01495k Abstract The ability to measure drugs in the body rapidly and in real time would advance both our understanding of pharmacokine... |
PMC6868114 | core_pubmed_pmc | Handling underlying discrete variables with bivariate mixed hidden Markov models in NONMEM | Handling underlying discrete variables with bivariate mixed hidden Markov models in NONMEM Abstract Non-linear mixed effects models typically deal with stochasticity in observed processes but models accounting for only observed processes may not be the most appropriate for all data. Hidden Markov models (HMMs) characte... |
PMC9436819 | core_pubmed_pmc | A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants | A Phase 1 Dose-Escalation Study of the Cardiac Myosin Inhibitor Aficamten in Healthy Participants Abstract Highlights • Certain genetic hypertrophic cardiomyopathies may result from hypercontractility of cardiac muscle, caused by pathogenic variants in genes encoding proteins of the cardiac sarcomere. • Aficamten (form... |
PMC6173237 | core_pubmed_pmc | Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study | Plasma concentrations of second-line antituberculosis drugs in relation to minimum inhibitory concentrations in multidrug-resistant tuberculosis patients in China: a study protocol of a prospective observational cohort study Abstract Introduction Individualised treatment through therapeutic drug monitoring (TDM) may im... |
PMC7251674 | core_pubmed_pmc | Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study | Influence of extracorporeal membrane oxygenation on the pharmacokinetics of ceftolozane/tazobactam: an ex vivo and in vivo study Abstract Abstract Background Extracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated... |
PMC12439278 | core_pubmed_pmc | From In Vitro Efficacy to Long‐Term HbA1c Response for GLP‐1R/GlucagonR Agonism Using the 4GI‐HbA1c Systems Model | From In Vitro Efficacy to Long‐Term HbA1c Response for GLP‐1R/GlucagonR Agonism Using the 4GI‐HbA1c Systems Model Abstract ABSTRACT For the treatment of Type 2 Diabetes, high efficacy approaches such as Glucagon‐like peptide 1 (GLP‐1)‐based therapies are recommended for glucose control. Prediction of the clinical outco... |
PMC6201488 | core_pubmed_pmc | Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood | Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood Abstract Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. A ultraperformance liquid chromatography-tandem mass spectrometr... |
PMC8632807 | core_pubmed_pmc | In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Profiles of Tulathromycin in an Experimental Intraperitoneal Haemophilus parasuis Infection Model in Neutropenic Guinea Pigs | In vivo Pharmacokinetic/Pharmacodynamic (PK/PD) Profiles of Tulathromycin in an Experimental Intraperitoneal Haemophilus parasuis Infection Model in Neutropenic Guinea Pigs Abstract Abstract Tulathromycin is a semi-synthetic macrolide antimicrobial that has an important role in veterinary medicine for respiratory disea... |
PMC10090446 | core_pubmed_pmc | Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients | Population pharmacokinetic analysis and dosing optimization of polymyxin B in critically ill patients Abstract Abstract Objectives: Since the global broadcast of multidrug-resistant gram-negative bacteria is accelerating, the use of Polymyxin B is sharply increasing, especially in critically ill patients. Unsatisfactor... |
PMC9296589 | core_pubmed_pmc | Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin‐resistant tuberculosis | Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin‐resistant tuberculosis Abstract Aims We aimed to explore the effect of pregnancy on bedaquiline pharmacokinetics (PK) and describe bedaquiline exposure in the breast milk of mothers treated for rifampicin‐resistant tuberculosis (TB), where the... |
PMC8609443 | core_pubmed_pmc | A practical strategy to subcutaneous administered in-situ gelling co-delivery system of arsenic and retinoic acid for the treatment of acute promyelocytic leukemia | A practical strategy to subcutaneous administered in-situ gelling co-delivery system of arsenic and retinoic acid for the treatment of acute promyelocytic leukemia Abstract Arsenic trioxide (ATO) combined with all trans retinoic acid (ATRA) is the first choice for the treatment of low and medium risk acute promyelocyti... |
PMC4273730 | core_pubmed_pmc | Theory-based analysis of clinical efficacy of triptans using receptor occupancy | Theory-based analysis of clinical efficacy of triptans using receptor occupancy Abstract Background Triptans, serotonin 5-HT 1B/1D receptor agonists, exert their action by targeting serotonin 5-HT 1B/1D receptors, are used for treatment of migraine attack. Presently, 5 different triptans, namely sumatriptan, zolmitript... |
PMC11680164 | core_pubmed_pmc | Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice | Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice Abstract Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of the vaccine response may be limited. Antiviral treatments, such as remdesi... |
PMC12473083 | core_pubmed_pmc | Designing a Small Molecule for PET Radiotracing: [ 18 F]MC225 in Human Trials for Early Diagnosis in CNS Pathologies | Designing a Small Molecule for PET Radiotracing: [ 18 F]MC225 in Human Trials for Early Diagnosis in CNS Pathologies Abstract Abstract P-Glycoprotein (P-gp, also known as MDR1 or ABCB1) is an ATP-binding cassette (ABC) transporter that actively effluxes a wide range of structurally and functionally diverse molecules, p... |
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