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32,242,875
Indian J Med Res
Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories.
Background & objectives: An outbreak of respiratory illness of unknown aetiology was reported from Hubei province of Wuhan, People's Republic of China, in December 2019. The outbreak was attributed to a novel coronavirus (CoV), named as severe acute respiratory syndrome (SARS)-CoV-2 and the disease as COVID-19. Within ...
virus research and diagnostic laboratory; diagnosis; preparedness; quality control; quarantine; severe acute respiratory syndrome-cov-2;covid-19
Journal Article
Gupta, Nivedita;Potdar, Varsha;Praharaj, Ira;Giri, Sidhartha;Sapkal, Gajanan;Yadav, Pragya;Choudhary, Manohar Lal;Dar, Lalit;Sugunan, A P;Kaur, Harmanmeet;Munivenkatappa, Ashok;Shastri, Jayanthi;Kaveri, Krishnasamy;Dutta, Shanta;Malhotra, Bharti;Jain, Amita;Nagamani, Kammilli;Shantala, G B;Raut, Sharmila;Vegad, M M;Sha...
10.4103/ijmr.IJMR_594_20
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories. [Abstract]: Background & objectives: An outbreak of respiratory illness of unknown aetiology was reported from Hubei province of Wuhan, People's Republic of China, in December 2019. The ou...
33,077,432
Occup Environ Med
COVID-19 risk management at the workplace, fear of infection and fear of transmission of infection among frontline employees.
OBJECTIVES: We compared COVID-19 risk management, fear of infection and fear of transmission of infection among frontline employees working within eldercare, hospital/rehabilitation, psychiatry, childcare and ambulance service and explored if group differences in fear of infection and transmission could be explained by...
communicable diseases;health and safety;health care workers;occupational health practice;public health
Journal Article;Research Support, Non-U.S. Gov't
Nabe-Nielsen, Kirsten;Nilsson, Charlotte Juul;Juul-Madsen, Maria;Bredal, Charlotte;Hansen, Lars Ole Preisler;Hansen, Ase Marie
10.1136/oemed-2020-106831
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: COVID-19 risk management at the workplace, fear of infection and fear of transmission of infection among frontline employees. [Abstract]: OBJECTIVES: We compared COVID-19 risk management, fear of infection and fear of transmission of infection among frontline employees working within eldercare, hospital/rehabi...
32,733,488
Front Immunol
Potential Fast COVID-19 Containment With Trehalose.
Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapidly spreading infecti...
covid-19;sars-cov-2;autophagy;prophylaxis;trehalose
Journal Article;Review
Martinon, Daisy;Borges, Vanessa F;Gomez, Angela C;Shimada, Kenichi
10.3389/fimmu.2020.01623
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: Potential Fast COVID-19 Containment With Trehalose. [Abstract]: Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and ...
32,668,058
J Thromb Haemost
Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis.
BACKGROUND: Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, and acute excessive inflammation are potential mechanisms reported by previous studies. Better understanding of the underlying mech...
covid-19;tafi;fibrinolysis;plasminogen activator inhibitor 1;thrombin generation;tissue plasminogen activator
Journal Article
Nougier, Christophe;Benoit, Remi;Simon, Marie;Desmurs-Clavel, Helene;Marcotte, Guillaume;Argaud, Laurent;David, Jean Stephane;Bonnet, Aurelie;Negrier, Claude;Dargaud, Yesim
10.1111/jth.15016
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis. [Abstract]: BACKGROUND: Thirty percent of Covid-19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, ...
32,583,078
Acta Diabetol
Diabetes increases the mortality of patients with COVID-19: a meta-analysis.
AIMS: Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovascular disease, and cerebrovascular disease are major risk factors for patients with COVID-19. METH...
covid-19;diabetes;meta-analysis;sars-cov-2
Journal Article;Meta-Analysis;Systematic Review
Wu, Zeng-Hong;Tang, Yun;Cheng, Qing
10.1007/s00592-020-01546-0
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Diabetes increases the mortality of patients with COVID-19: a meta-analysis. [Abstract]: AIMS: Nowadays, the ongoing pandemic of COVID-19 caused by the novel coronavirus Syndrome-Coronavirus-2 (SARS-CoV-2) is an emerging, rapidly evolving situation. Complications such as hypertension, diabetes, COPD, cardiovas...
32,660,218
Epidemiol Health
Air filtration and SARS-CoV-2.
Air filtration in various implementations has become a critical intervention in managing the spread of coronavirus disease 2019 (COVID-19). However, the proper deployment of air filtration has been hampered by an insufficient understanding of its principles. These misconceptions have led to uncertainty about the effect...
aerosols;covid-19;coronavirus;filtration;hepa;mpps
Journal Article
Nazarenko, Yevgen
10.4178/epih.e2020049
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Air filtration and SARS-CoV-2. [Abstract]: Air filtration in various implementations has become a critical intervention in managing the spread of coronavirus disease 2019 (COVID-19). However, the proper deployment of air filtration has been hampered by an insufficient understanding of its principles. These mis...
32,037,389
Biosci Trends
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.
Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Sh...
2019-ncov;shufeng jiedu capsule;arbidol;lopinavir;ritonavir
Case Reports;Journal Article
Wang, Zhenwei;Chen, Xiaorong;Lu, Yunfei;Chen, Feifei;Zhang, Wei
10.5582/bst.2020.01030
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. [Abstract]: Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antivi...
32,942,143
Biosens Bioelectron
Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases.
Global health and food security constantly face the challenge of emerging human and plant diseases caused by bacteria, viruses, fungi, and other pathogens. Disease outbreaks such as SARS, MERS, Swine Flu, Ebola, and COVID-19 (on-going) have caused suffering, death, and economic losses worldwide. To prevent the spread o...
dna/rna extraction;infectious diseases;nucleic acid amplification;plant diseases;point-of-care diagnostics;raw samples
Journal Article;Review
Paul, Rajesh;Ostermann, Emily;Wei, Qingshan
10.1016/j.bios.2020.112592
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Advances in point-of-care nucleic acid extraction technologies for rapid diagnosis of human and plant diseases. [Abstract]: Global health and food security constantly face the challenge of emerging human and plant diseases caused by bacteria, viruses, fungi, and other pathogens. Disease outbreaks such as SARS,...
32,841,215
JCI Insight
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease.
The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection owing to low-affinity binding to the murine angiotensin-converting enzyme 2 (ACE2) pr...
covid-19;infectious disease;molecular pathology;mouse models
Journal Article;Research Support, Non-U.S. Gov't
Golden, Joseph W;Cline, Curtis R;Zeng, Xiankun;Garrison, Aura R;Carey, Brian D;Mucker, Eric M;White, Lauren E;Shamblin, Joshua D;Brocato, Rebecca L;Liu, Jun;Babka, April M;Rauch, Hypaitia B;Smith, Jeffrey M;Hollidge, Bradley S;Fitzpatrick, Collin;Badger, Catherine V;Hooper, Jay W
10.1172/jci.insight.142032
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease. [Abstract]: The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (M...
32,328,364
Cureus
Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy.
Coronavirus disease 2019 (COVID-19) is a pandemic. Neurological complications of COVID-19 have not been reported. Encephalopathy has not been described as a presenting symptom or complication of COVID-19. We report a case of a 74-year-old patient who traveled from Europe to the United States and presented with encephal...
covid-19;encephalopathy
Case Reports
Filatov, Asia;Sharma, Pamraj;Hindi, Fawzi;Espinosa, Patricio S
10.7759/cureus.7352
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Neurological Complications of Coronavirus Disease (COVID-19): Encephalopathy. [Abstract]: Coronavirus disease 2019 (COVID-19) is a pandemic. Neurological complications of COVID-19 have not been reported. Encephalopathy has not been described as a presenting symptom or complication of COVID-19. We report a case...
32,895,065
Infect Control Hosp Epidemiol
Impact of the coronavirus disease 2019 (COVID-19) pandemic on nosocomial Clostridioides difficile infection.
OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has induced a reinforcement of infection control measures in the hospital setting. Here, we assess the impact of the COVID-19 pandemic on the incidence of nosocomial Clostridioides difficile infection (CDI). METHODS: We retrospectively compared the incidence ...
Journal Article
Ponce-Alonso, Manuel;Saez de la Fuente, Javier;Rincon-Carlavilla, Angela;Moreno-Nunez, Paloma;Martinez-Garcia, Laura;Escudero-Sanchez, Rosa;Pintor, Rosario;Garcia-Fernandez, Sergio;Cobo, Javier
10.1017/ice.2020.454
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Impact of the coronavirus disease 2019 (COVID-19) pandemic on nosocomial Clostridioides difficile infection. [Abstract]: OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has induced a reinforcement of infection control measures in the hospital setting. Here, we assess the impact of the COVID-19 pan...
33,051,386
Brain Nerve
[Neuromuscular Manifestations and Pathogenesis of COVID-19].
A novel coronavirus infection, coronavirus disease 2019 (COVID-19), is frequently associated with neuromuscular symptoms. It is characterized by taste and smell disturbances, and nonspecific symptoms such as headache and dizziness. Neuromuscular complications such as cerebrovascular disease, encephalopathy, meningoence...
Journal Article
Shimohata, Takayoshi
10.11477/mf.1416201642
[ 0, 1, 0, 1, 0, 0, 0 ]
[Title]: [Neuromuscular Manifestations and Pathogenesis of COVID-19]. [Abstract]: A novel coronavirus infection, coronavirus disease 2019 (COVID-19), is frequently associated with neuromuscular symptoms. It is characterized by taste and smell disturbances, and nonspecific symptoms such as headache and dizziness. Neurom...
32,425,182
G Ital Cardiol (Rome)
[Risk communication during the COVID-19 pandemic: lessons for lifestyle interventions in cardiovascular prevention].
Lifestyle is a cornerstone of cardiovascular prevention and the process of risk communication constitutes an important step to obtain favorable changes in daily habits. Nevertheless, there is no definite consensus on how health operators should provide information on cardiovascular risk, and several models have been pr...
Journal Article
Angelino, Elisabetta;Ambrosetti, Marco;Fattirolli, Francesco
10.1714/3359.33321
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: [Risk communication during the COVID-19 pandemic: lessons for lifestyle interventions in cardiovascular prevention]. [Abstract]: Lifestyle is a cornerstone of cardiovascular prevention and the process of risk communication constitutes an important step to obtain favorable changes in daily habits. Nevertheless,...
32,725,087
Cad Saude Publica
Description and comparison of demographic characteristics and comorbidities in SARI from COVID-19, SARI from influenza, and the Brazilian general population.
The study aims to describe patients hospitalized for severe acute respiratory illness (SARI) due to COVID-19 (SARI-COVID) in Brazil according to demographic characteristics and comorbidities up to the 21st Epidemiological Week of 2020. The study aimed to compare these characteristics with those of patients hospitalized...
Comparative Study;Journal Article
Niquini, Roberta Pereira;Lana, Raquel Martins;Pacheco, Antonio Guilherme;Cruz, Oswaldo Goncalves;Coelho, Flavio Codeco;Carvalho, Luiz Max;Villela, Daniel Antunes Maciel;Gomes, Marcelo Ferreira da Costa;Bastos, Leonardo Soares
10.1590/0102-311x00149420
[ 0, 1, 1, 0, 0, 0, 0 ]
[Title]: Description and comparison of demographic characteristics and comorbidities in SARI from COVID-19, SARI from influenza, and the Brazilian general population. [Abstract]: The study aims to describe patients hospitalized for severe acute respiratory illness (SARI) due to COVID-19 (SARI-COVID) in Brazil according...
32,515,393
J Pak Med Assoc
Long term complications and rehabilitation of COVID-19 patients.
With the ongoing pandemic of COVID-19 having caught the world almost unaware millions of people across the globe are presently grappling to deal with its acute effects . Our previous experience with members of the same corona virus family (SARS and MERS) which have caused two major epidemics in the past albeit of much ...
covid 19, long term complications, cardiopulmonary, glucometabolic, neuropsychiatric
Journal Article
Dasgupta, Arundhati;Kalhan, Atul;Kalra, Sanjay
10.5455/JPMA.32
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Long term complications and rehabilitation of COVID-19 patients. [Abstract]: With the ongoing pandemic of COVID-19 having caught the world almost unaware millions of people across the globe are presently grappling to deal with its acute effects . Our previous experience with members of the same corona virus fa...
32,396,101
IEEE Rev Biomed Eng
Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic.
Coronavirus disease 2019 (COVID-19) has emerged as a pandemic with serious clinical manifestations including death. A pandemic at the large-scale like COVID-19 places extraordinary demands on the world's health systems, dramatically devastates vulnerable populations, and critically threatens the global communities in a...
Journal Article;Review
Ding, Xiao-Rong;Clifton, David;Ji, Nan;Lovell, Nigel Hamilton;Bonato, Paolo;Chen, Wei;Yu, Xinge;Xue, Zhong;Xiang, Ting;Long, Xi;Xu, Ke;Jiang, Xinyu;Wang, Qi;Yin, Bin;Feng, Guodong;Zhang, Yuanting
10.1109/RBME.2020.2992838
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic. [Abstract]: Coronavirus disease 2019 (COVID-19) has emerged as a pandemic with serious clinical manifestations including death. A pandemic at the large-scale like COVID-19 places extraordinary demands on the wor...
32,778,180
Epidemiol Infect
COVID-19 in India: transmission dynamics, epidemiological characteristics, testing, recovery and effect of weather.
The spread of COVID-19 is recent in India, which has within 4 months caused over 190 000 infections, as of 1 June 2020, despite four stringent lockdowns. With the current rate of the disease transmission in India, which is home to over 1.35 billion people, the infection spread is predicted to be worse than the USA in t...
covid-19;coronavirus;india;epidemiology;transmission;weather
Journal Article
Chanda, Arnab
10.1017/S0950268820001776
[ 0, 1, 1, 0, 1, 0, 0 ]
[Title]: COVID-19 in India: transmission dynamics, epidemiological characteristics, testing, recovery and effect of weather. [Abstract]: The spread of COVID-19 is recent in India, which has within 4 months caused over 190 000 infections, as of 1 June 2020, despite four stringent lockdowns. With the current rate of the ...
32,869,133
Aesthetic Plast Surg
The Role of Virtual Consultations in Plastic Surgery During COVID-19 Lockdown.
BACKGROUND: COVID-19 has led to government enforced 'lockdown' in the UK severely limiting face-to-face patient interaction. Virtual consultations present a means for continued patient access to health care. Our aim was to evaluate the use of virtual consultations (VCons) during lockdown and their possible role in the ...
patient safety;plastic surgery;technology;telemedicine;virtual consultation
Journal Article
Sinha, Vikram;Malik, Mohsan;Nugent, Nora;Drake, Paul;Cavale, Naveen
10.1007/s00266-020-01932-7
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: The Role of Virtual Consultations in Plastic Surgery During COVID-19 Lockdown. [Abstract]: BACKGROUND: COVID-19 has led to government enforced 'lockdown' in the UK severely limiting face-to-face patient interaction. Virtual consultations present a means for continued patient access to health care. Our aim was ...
32,641,171
J Laryngol Otol
Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method.
BACKGROUND: Fibre-optic nasoendoscopy and fibre-optic laryngoscopy are high-risk procedures in the coronavirus disease 2019 era, as they are potential aerosol-generating procedures. Barrier protection remains key to preventing transmission. METHODS: A device was developed that patients can wear to reduce potential aero...
covid-19;coronavirus;laryngoscopy;otolaryngologists;personal protective equipment
Journal Article
Curran, J;Calder, N;Yaneza, M;Iyer, A
10.1017/S0022215120001413
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method. [Abstract]: BACKGROUND: Fibre-optic nasoendoscopy and fibre-optic laryngoscopy are high-risk procedures in the coronavirus disease 2019 era, as they are potential aerosol-generating procedures. Barrier protection remains key to...
32,781,669
Int J Environ Res Public Health
An Examination on the Transmission of COVID-19 and the Effect of Response Strategies: A Comparative Analysis.
The major purpose of this paper was to examine the transmission of COVID-19 and the associated factors that affect the transmission. A qualitative analysis was conducted by comparing the COVID-19 transmission of six countries: China, Korea, Japan, Italy, the USA, and Brazil. This paper attempted to examine the mitigati...
covid-19;mitigation effectiveness;pandemic severity;transmission;viral testing
Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Chen, Yi-Tui;Yen, Yung-Feng;Yu, Shih-Heng;Su, Emily Chia-Yu
10.3390/ijerph17165687
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: An Examination on the Transmission of COVID-19 and the Effect of Response Strategies: A Comparative Analysis. [Abstract]: The major purpose of this paper was to examine the transmission of COVID-19 and the associated factors that affect the transmission. A qualitative analysis was conducted by comparing the CO...
32,875,970
Perit Dial Int
Peritoneal dialysis for treatment of acute kidney injury in a case of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2.
This short report describes the case discussion of 9-year-old patient with acute kidney injury due to paediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 with successful peritoneal dialysis via a peritoneal dialysis catheter inserted at the bedside in ...
aki;pims-ts;sars-cov-2;peritoneal dialysis
Case Reports;Journal Article
McCulloch, Mignon;Abugrain, Khadija;Mosalakatane, Thembisile;Coetzee, Ashton;Webb, Kate;Scott, Christiaan
10.1177/0896860820953716
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Peritoneal dialysis for treatment of acute kidney injury in a case of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. [Abstract]: This short report describes the case discussion of 9-year-old patient with acute kidney injury due to paediatric inflammatory multisystem syndrom...
32,921,862
Biocybern Biomed Eng
A deep learning approach to detect Covid-19 coronavirus with X-Ray images.
Rapid and accurate detection of COVID-19 coronavirus is necessity of time to prevent and control of this pandemic by timely quarantine and medical treatment in absence of any vaccine. Daily increase in cases of COVID-19 patients worldwide and limited number of available detection kits pose difficulty in identifying the...
computer-aided diagnosis;coronavirus detection;covid-19;deep learning;pneumonia;x-ray
Journal Article
Jain, Govardhan;Mittal, Deepti;Thakur, Daksh;Mittal, Madhup K
10.1016/j.bbe.2020.08.008
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: A deep learning approach to detect Covid-19 coronavirus with X-Ray images. [Abstract]: Rapid and accurate detection of COVID-19 coronavirus is necessity of time to prevent and control of this pandemic by timely quarantine and medical treatment in absence of any vaccine. Daily increase in cases of COVID-19 pati...
33,045,596
Med Hypotheses
A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections.
Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment. Zinc is a vital microelement that actively supports respiratory epithelium barrier integrity, innate and...
antiviral;covid-19;hinokitiol;sars-cov-2;zinc;zinc ionophore
Journal Article
Hoang, Ba X;Han, Bo
10.1016/j.mehy.2020.110333
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections. [Abstract]: Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable ...
32,862,289
Eur Radiol
Observer agreement and clinical significance of chest CT reporting in patients suspected of COVID-19.
OBJECTIVES: To assess interobserver agreement and clinical significance of chest CT reporting in patients suspected of COVID-19. METHODS: From 16 to 24 March 2020, 241 consecutive patients addressed to hospital for COVID-19 suspicion had both chest CT and SARS-CoV-2 RT-PCR. Eight observers (2 thoracic and 2 general sen...
coronavirus infections;pneumonia;tomography, x-ray computed
Journal Article
Debray, Marie-Pierre;Tarabay, Helena;Males, Lisa;Chalhoub, Nisrine;Mahdjoub, Elyas;Pavlovsky, Thomas;Visseaux, Benoit;Bouzid, Donia;Borie, Raphael;Wackenheim, Catherine;Crestani, Bruno;Rioux, Christophe;Saker, Loukbi;Choquet, Christophe;Mullaert, Jimmy;Khalil, Antoine
10.1007/s00330-020-07126-8
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Observer agreement and clinical significance of chest CT reporting in patients suspected of COVID-19. [Abstract]: OBJECTIVES: To assess interobserver agreement and clinical significance of chest CT reporting in patients suspected of COVID-19. METHODS: From 16 to 24 March 2020, 241 consecutive patients addresse...
33,051,394
Brain Nerve
[Neurological Manifestations of COVID-19 and Work-up at the Emergency Room and the Intensive Care Unit].
The global pandemic due to the Coronavirus Disease 2019 (COVID-19) has placed tremendous strain on healthcare services. This review provides guidance to neurologists on the appropriate management of neurological and neurocritical conditions and diseases during the COVID-19 pandemic in the emergency room and the intensi...
Journal Article;Review
Nagayama, Masao
10.11477/mf.1416201650
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: [Neurological Manifestations of COVID-19 and Work-up at the Emergency Room and the Intensive Care Unit]. [Abstract]: The global pandemic due to the Coronavirus Disease 2019 (COVID-19) has placed tremendous strain on healthcare services. This review provides guidance to neurologists on the appropriate managemen...
32,720,233
J Neurovirol
Severe rapidly progressive Guillain-Barre syndrome in the setting of acute COVID-19 disease.
There is concern that the global burden of coronavirus disease of 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection might yield an increased occurrence of Guillain-Barre syndrome (GBS). It is currently unknown whether concomitant SARS-CoV-2 infection and GBS are pathophysiolo...
coronavirus-19;guillain-barre syndrome;neuromuscular disorders;polyneuropathy;sars-cov-2
Case Reports;Journal Article
Abrams, Rory M C;Kim, Brian D;Markantone, Desiree M;Reilly, Kaitlin;Paniz-Mondolfi, Alberto E;Gitman, Melissa R;Choo, S Yoon;Tse, Winona;Robinson-Papp, Jessica
10.1007/s13365-020-00884-7
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Severe rapidly progressive Guillain-Barre syndrome in the setting of acute COVID-19 disease. [Abstract]: There is concern that the global burden of coronavirus disease of 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection might yield an increased occurrence of Guillai...
32,348,054
Rev Med Suisse
[Left behind populations, COVID-19 and risks of health inequities : a guide of the local social-health network (Vaud, Switzerland)].
Since the emergence of the COVID-19 pandemic, the Confederation has referred to << vulnerable populations >> over the age of 65 and/or with co-morbidities as potentially at risk. This group should not overshadow other highly vulnerable populations such as forced migrants, people deprived of their liberty, and the homel...
Journal Article
Bodenmann, Patrick;Pahud-Vermeulen, Brigitte;Bouche, Laurence;Sanchis Zozaya, Javier;Bauermeister, Murielle;Berzig, Ahmed
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: [Left behind populations, COVID-19 and risks of health inequities : a guide of the local social-health network (Vaud, Switzerland)]. [Abstract]: Since the emergence of the COVID-19 pandemic, the Confederation has referred to << vulnerable populations >> over the age of 65 and/or with co-morbidities as potentia...
32,662,099
Drug Dev Res
Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome.
Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavirus (CoV) known as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). As much as the researchers are inundate...
covid-19;sars cov-2;antiviral drugs;cytokines;nonstructural proteins;pneumonia;severe acute respiratory syndrome;viremia
Journal Article;Review
Sadia, Aatika;Basra, Muhammad Asim Raza
10.1002/ddr.21710
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Therapeutic dilemma in the repression of severe acute respiratory syndrome coronavirus-2 proteome. [Abstract]: Currently, the pandemic coronavirus disease 2019 (COVID-19) has unprecedentedly captivated its human hosts by causing respiratory illnesses because of evolution of the genetic makeup of novel coronavi...
32,359,227
Am J Perinatol
Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2.
OBJECTIVE: To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate postdischarge SARS-CoV-2 status of newborns to mothers with COVID-19 in pregnancy that, at birth, were ne...
Journal Article;Observational Study
Buonsenso, Danilo;Costa, Simonetta;Sanguinetti, Maurizio;Cattani, Paola;Posteraro, Brunella;Marchetti, Simona;Carducci, Brigida;Lanzone, Antonio;Tamburrini, Enrica;Vento, Giovanni;Valentini, Piero
10.1055/s-0040-1710541
[ 0, 1, 1, 0, 0, 0, 0 ]
[Title]: Neonatal Late Onset Infection with Severe Acute Respiratory Syndrome Coronavirus 2. [Abstract]: OBJECTIVE: To date, no information on late-onset infection in newborns to mother with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contracted in pregnancy are available. This study aimed to evaluate ...
32,964,913
Clin Infect Dis
Decreased mortality in COVID-19 patients treated with Tocilizumab: a rapid systematic review and meta-analysis of observational studies.
BACKGROUND: We systematically reviewed the literature to answer the following research questions: 1) does IL-6 (receptor) antagonist therapy reduce mortality in COVID-19 patients compared to patients not treated with IL-6 (receptor) antagonists and 2) is there an increased risk of side effects in COVID-19 patients trea...
covid-19;il-6 receptor antagonists;mortality;tocilizumab
Journal Article
Malgie, Jishnu;Schoones, Jan W;Pijls, Bart G
10.1093/cid/ciaa1445
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Decreased mortality in COVID-19 patients treated with Tocilizumab: a rapid systematic review and meta-analysis of observational studies. [Abstract]: BACKGROUND: We systematically reviewed the literature to answer the following research questions: 1) does IL-6 (receptor) antagonist therapy reduce mortality in C...
33,062,951
ACS Pharmacol Transl Sci
SARS-CoV-2 Vaccine Development: An Overview and Perspectives.
Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, China, and by mid-March 2020, the disease had spread globally. As of July 17, 2020, this pandemic virus has infected...
Journal Article;Review
Liu, Yi;Wang, Kai;Massoud, Tarik F;Paulmurugan, Ramasamy
10.1021/acsptsci.0c00109
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: SARS-CoV-2 Vaccine Development: An Overview and Perspectives. [Abstract]: Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, China, and by mid-March 2020, the...
32,935,064
Heliyon
Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects?
The COVID-19 outbreak emerged in December 2019 and has rapidly become a global pandemic. A great deal of effort has been made to find effective drugs against this disease. Chloroquine (CQ) and hydroxychloroquine (HCQ) were widely adopted in treating COVID-19, but the results were contradictive. CQ/HCQ have been used to...
calcium;cardiology;chloroquine;clinical toxicology;eye-ear-nose-throat;hcn;hydroxychloroquine;immunology;infectious disease;internal medicine;neurology;pathology;pharmacology;sars-cov-2;toxicology
Journal Article;Review
Zhan, Xiping;Dowell, Sharon;Shen, Ying;Lee, Dexter L
10.1016/j.heliyon.2020.e04900
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Chloroquine to fight COVID-19: A consideration of mechanisms and adverse effects? [Abstract]: The COVID-19 outbreak emerged in December 2019 and has rapidly become a global pandemic. A great deal of effort has been made to find effective drugs against this disease. Chloroquine (CQ) and hydroxychloroquine (HCQ)...
32,919,586
Healthc (Amst)
Qualitative review of early experiences of off-site COVID-19 testing centers and associated considerations.
Given the predicted need for continued SARS-CoV-2 diagnostic testing, as well as the evolving availability and types of diagnostic tests, off-site COVID-19 testing centers (OSCTC) leaders need timely guidance to ensure they are meeting the needs of their unique populations. This research discusses the challenges and of...
covid-19;ppe;regional;testing
Journal Article
Brammer, Craig;Donohue, Stacy;Elwell, Timothy;Fishbein, Eliza;Forschino, D'Ante;Horne, Dorothy;Lloyd-Krejci, Buffy;Little, Jessica;Nikiforova, Bistra;Winterbauer, Elizabeth
10.1016/j.hjdsi.2020.100449
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Qualitative review of early experiences of off-site COVID-19 testing centers and associated considerations. [Abstract]: Given the predicted need for continued SARS-CoV-2 diagnostic testing, as well as the evolving availability and types of diagnostic tests, off-site COVID-19 testing centers (OSCTC) leaders nee...
32,386,848
Mol Genet Metab
Impact of COVID-19 related healthcare crisis on treatments for patients with lysosomal storage disorders, the first Italian experience.
The direct and indirect effects of Coronavirus Disease-19 (COVID-19) pandemic, on Italian patients with lysosomal storage disorders receiving therapy, were analyzed by a phone questionnaire. No proved COVID-19 emerged among 102 interviewed. No problems were reported by patients receiving oral treatments. Forty-nine% of...
covid-19;enzyme replacement therapy;lysosomal storage disorders
Journal Article
Sechi, Annalisa;Macor, Daniela;Valent, Serena;Da Riol, Rosalia Maria;Zanatta, Manuela;Spinelli, Alessandro;Bianchi, Katja;Bertossi, Nadia;Dardis, Andrea;Valent, Francesca;Scarpa, Maurizio
10.1016/j.ymgme.2020.04.002
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Impact of COVID-19 related healthcare crisis on treatments for patients with lysosomal storage disorders, the first Italian experience. [Abstract]: The direct and indirect effects of Coronavirus Disease-19 (COVID-19) pandemic, on Italian patients with lysosomal storage disorders receiving therapy, were analyze...
32,645,630
Int Immunopharmacol
Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis.
BACKGROUND: There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS: A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science ...
human coronavirus;mers-cov;sars-cov;sars-cov-2;type i interferons
Journal Article;Meta-Analysis;Systematic Review
Yu, Chengjun;Kang, Lian;Chen, Jiadong;Zang, Na
10.1016/j.intimp.2020.106740
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis. [Abstract]: BACKGROUND: There is no vaccine or specific antiviral treatment for HCoVs infec...
32,835,530
Clin Exp Hypertens
Survival rate in hypertensive patients with COVID-19.
INTRODUCTION: A life-threatening respiratory disease, coronavirus 2019 (COVID-19), has spread across the globe since December 2019. Many prognostic factors have already been put forward to predict the risk of death and other outcomes. The current study is evaluating the survival rate between hypertensive and non-hypert...
covid-19;hypertension;survival
Journal Article
Emami, Amir;Javanmardi, Fatemeh;Akbari, Ali;Kojuri, Javad;Bakhtiari, Hamid;Rezaei, Tahereh;Keshavarzi, Abdolkhalegh;Falahati, Farshad
10.1080/10641963.2020.1812624
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Survival rate in hypertensive patients with COVID-19. [Abstract]: INTRODUCTION: A life-threatening respiratory disease, coronavirus 2019 (COVID-19), has spread across the globe since December 2019. Many prognostic factors have already been put forward to predict the risk of death and other outcomes. The curren...
33,064,753
PLoS One
COVID-19 observations and accompanying dataset of non-pharmaceutical interventions across U.S. universities, March 2020.
BACKGROUND: The Centers for Disease Control and Prevention (CDC) publishes COVID-19 non-pharmaceutical intervention (NPI) guidance for specific institutional audiences to limit community spread. Audiences include: business, clinical, public health, education, community, and state/local government. The swift, severe, an...
Journal Article
Cevasco, Kevin E;North, Hayley M;Zeitoun, Sheryne A;Wofford, Rachel N;Matulis, Graham A;Gregory, Abigail F;Hassan, Maha H;Abdo, Aya D;Farris, David;Roess, Amira A;von Fricken, Michael E
10.1371/journal.pone.0240786
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: COVID-19 observations and accompanying dataset of non-pharmaceutical interventions across U.S. universities, March 2020. [Abstract]: BACKGROUND: The Centers for Disease Control and Prevention (CDC) publishes COVID-19 non-pharmaceutical intervention (NPI) guidance for specific institutional audiences to limit c...
32,460,133
Crit Rev Oncol Hematol
Considerations for interactions of drugs used for the treatment of COVID-19 with anti-cancer treatments.
SARS-CoV2 infection is an emerging issue worldwide. Cancer patient are at increased risk of infection compared to general population. On the other hand, these patients are at major risk of drug interactions caused by renal and hepatic impairment background. Because of the long-term use of chemotherapy drugs, drug inter...
covid-19;cancer;chemotherapy;drug interaction;sars-cov2
Journal Article;Review
Jafari, Anya;Dadkhahfar, Sahar;Perseh, Sahra
10.1016/j.critrevonc.2020.102982
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Considerations for interactions of drugs used for the treatment of COVID-19 with anti-cancer treatments. [Abstract]: SARS-CoV2 infection is an emerging issue worldwide. Cancer patient are at increased risk of infection compared to general population. On the other hand, these patients are at major risk of drug ...
32,219,006
Quant Biol
Modeling the epidemic dynamics and control of COVID-19 outbreak in China.
Background: The coronavirus disease 2019 (COVID-19) is rapidly spreading in China and more than 30 countries over last two months. COVID-19 has multiple characteristics distinct from other infectious diseases, including high infectivity during incubation, time delay between real dynamics and daily observed number of co...
sars-cov-2;coronavirus disease 2019;epidemic model
Journal Article
Zhao, Shilei;Chen, Hua
10.1007/s40484-020-0199-0
[ 0, 0, 1, 0, 0, 1, 0 ]
[Title]: Modeling the epidemic dynamics and control of COVID-19 outbreak in China. [Abstract]: Background: The coronavirus disease 2019 (COVID-19) is rapidly spreading in China and more than 30 countries over last two months. COVID-19 has multiple characteristics distinct from other infectious diseases, including high ...
32,437,338
MMWR Morb Mortal Wkly Rep
High COVID-19 Attack Rate Among Attendees at Events at a Church - Arkansas, March 2020.
On March 16, 2020, the day that national social distancing guidelines were released (1), the Arkansas Department of Health (ADH) was notified of two cases of coronavirus disease 2019 (COVID-19) from a rural county of approximately 25,000 persons; these cases were the first identified in this county. The two cases occur...
Journal Article
James, Allison;Eagle, Lesli;Phillips, Cassandra;Hedges, D Stephen;Bodenhamer, Cathie;Brown, Robin;Wheeler, J Gary;Kirking, Hannah
10.15585/mmwr.mm6920e2
[ 0, 0, 1, 0, 1, 0, 0 ]
[Title]: High COVID-19 Attack Rate Among Attendees at Events at a Church - Arkansas, March 2020. [Abstract]: On March 16, 2020, the day that national social distancing guidelines were released (1), the Arkansas Department of Health (ADH) was notified of two cases of coronavirus disease 2019 (COVID-19) from a rural coun...
32,176,772
Clin Infect Dis
Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China.
BACKGROUND: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed. METHODS: We reviewed 69 patients who were hospitalized in Union hospital in Wuhan...
wuhan;coronavirus;pneumonia
Journal Article
Wang, Zhongliang;Yang, Bohan;Li, Qianwen;Wen, Lu;Zhang, Ruiguang
10.1093/cid/ciaa272
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China. [Abstract]: BACKGROUND: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical feat...
32,302,435
J Thromb Haemost
Thrombocytopenia and its association with mortality in patients with COVID-19.
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease 2019 (COVID-19), is spreading rapidly around the world. Thrombocytopenia in patients with COVID-19 has not been fully studied. OBJECTIVE: To describe thrombocytopenia in patients with COVID-19. METHODS: For ...
covid-19;sars-cov-2;generalized linear model;mortality;thrombocytopenia
Comparative Study;Journal Article
Yang, Xiaobo;Yang, Qingyu;Wang, Yaxin;Wu, Yongran;Xu, Jiqian;Yu, Yuan;Shang, You
10.1111/jth.14848
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Thrombocytopenia and its association with mortality in patients with COVID-19. [Abstract]: BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease 2019 (COVID-19), is spreading rapidly around the world. Thrombocytopenia in patients with COVID-19 has not ...
33,037,564
Plant Foods Hum Nutr
Potential Inhibitors for SARS-CoV-2 and Functional Food Components as Nutritional Supplement for COVID-19: A Review.
The severe acute respiratory syndrome is a viral respiratory infection and commonly called as COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It widely transmitted through direct or indirect contact. Currently, no specific treatment against SARS-CoV-2 are available; only prevention and...
covid-19;food ingredients;immune-boosting;potential inhibitors;sars-cov-2
Journal Article;Review
Singh, Pushpendra;Tripathi, Manish Kumar;Yasir, Mohammad;Khare, Ruchi;Tripathi, Manoj Kumar;Shrivastava, Rahul
10.1007/s11130-020-00861-9
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Potential Inhibitors for SARS-CoV-2 and Functional Food Components as Nutritional Supplement for COVID-19: A Review. [Abstract]: The severe acute respiratory syndrome is a viral respiratory infection and commonly called as COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It wid...
32,313,181
Bone Marrow Transplant
Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati.
Italy is the second exposed country worldwide, after China, and Lombardia is the most affected region in Italy, with more than half of the national cases, with 13% of whom being healthcare professionals. The Clinica Pediatrica Universita degli Studi di Milano Bicocca is a general pediatric and hematology oncology and t...
Journal Article;Review
Balduzzi, Adriana;Brivio, Erica;Rovelli, Attilio;Rizzari, Carmelo;Gasperini, Serena;Melzi, Maria Luisa;Conter, Valentino;Biondi, Andrea
10.1038/s41409-020-0895-4
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Lessons after the early management of the COVID-19 outbreak in a pediatric transplant and hemato-oncology center embedded within a COVID-19 dedicated hospital in Lombardia, Italy. Estote parati. [Abstract]: Italy is the second exposed country worldwide, after China, and Lombardia is the most affected region in...
33,078,135
Econ Disaster Clim Chang
COVID-19: The impact of social distancing policies, cross-country analysis.
At the onset of the COVID-19 pandemic a large number of countries introduced a range of non-pharmaceutical interventions. Whereas the policies are similar across countries, country characteristics vary substantially. We examine the effectiveness of such policies using a cross-country variation in socio-economic, enviro...
covid-19;cross-country analysis;non-pharmaceutical interventions
Journal Article
Castex, Gonzalo;Dechter, Evgenia;Lorca, Miguel
10.1007/s41885-020-00076-x
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: COVID-19: The impact of social distancing policies, cross-country analysis. [Abstract]: At the onset of the COVID-19 pandemic a large number of countries introduced a range of non-pharmaceutical interventions. Whereas the policies are similar across countries, country characteristics vary substantially. We exa...
32,710,646
J Med Virol
Is it all in the heart? Myocardial injury as major predictor of mortality among hospitalized COVID-19 patients.
Coronavirus disease 2019 (COVID-19) is an infection caused by the virus SARS-CoV-2, and has caused the most widespread global pandemic in over 100 years. Given the novelty of the disease, risk factors of mortality and adverse outcomes in hospitalized patients remain to be elucidated. We present the results of a retrosp...
cellular effect;coronavirus;epidemiology;pandemics;physiology;virus classification
Journal Article
Harmouch, Farah;Shah, Kashyap;Hippen, John T;Kumar, Ashish;Goel, Harsh
10.1002/jmv.26347
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Is it all in the heart? Myocardial injury as major predictor of mortality among hospitalized COVID-19 patients. [Abstract]: Coronavirus disease 2019 (COVID-19) is an infection caused by the virus SARS-CoV-2, and has caused the most widespread global pandemic in over 100 years. Given the novelty of the disease,...
32,841,117
IEEE Pulse
COVID-19 Testing: What New Mexico Did Right.
Unlike many other states across America that struggled to get enough diagnostic tests for coronavirus 2019 disease (COVID-19) this past spring, New Mexico was able to not only meet the demand for testing symptomatic patients, but was able to begin expanding its screening to asymptomatic individuals. How did this largel...
Journal Article
Mertz, Leslie
10.1109/MPULS.2020.3008450
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: COVID-19 Testing: What New Mexico Did Right. [Abstract]: Unlike many other states across America that struggled to get enough diagnostic tests for coronavirus 2019 disease (COVID-19) this past spring, New Mexico was able to not only meet the demand for testing symptomatic patients, but was able to begin expand...
32,499,187
J Plast Reconstr Aesthet Surg
How the COVID-19 pandemic changed the Plastic Surgery activity in a regional referral center in Northern Italy.
The Covid 19 epidemic has modified the way that plastic surgeons can treat their patients. At our hospital all elective surgery was canceled and only the more severe cases were admitted. The outpatient department activity has been reduced also. We present the number and diagnoses of patients, treated as in- and out-pat...
corona virus pandemic;covid-19;plastic surgery;telemedicine
Journal Article
Pignatti, Marco;Pinto, Valentina;Miralles, Maria Elisa Lozano;Giorgini, Federico A;Cannamela, Giacomo;Cipriani, Riccardo
10.1016/j.bjps.2020.05.002
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: How the COVID-19 pandemic changed the Plastic Surgery activity in a regional referral center in Northern Italy. [Abstract]: The Covid 19 epidemic has modified the way that plastic surgeons can treat their patients. At our hospital all elective surgery was canceled and only the more severe cases were admitted. ...
32,837,212
Prat Anesth Reanim
[Nutritional support for critically ill patients suffering from SARS-CoV-2 infection].
Patients with severe cases of COVID-19 are at high nutritional risk during their ICU stay. Prolonged immobilization associated with an exacerbated systemic inflammatory response is a major provider of ICU-acquired muscle weakness. Early enteral nutrition is recommended to gradually reach the energy target of 25 kcal/kg...
covid-19;fish oil;nutrition;refeeding syndrome
English Abstract;Journal Article;Review
Pardo, Emmanuel
10.1016/j.pratan.2020.07.002
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: [Nutritional support for critically ill patients suffering from SARS-CoV-2 infection]. [Abstract]: Patients with severe cases of COVID-19 are at high nutritional risk during their ICU stay. Prolonged immobilization associated with an exacerbated systemic inflammatory response is a major provider of ICU-acquire...
32,455,942
Molecules
Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming.
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2') cleavage sites that are processed by human host proteases. The exact nature of these cleavage sites, and their respective p...
anthrax toxin;covid19;sars-cov2;tmprss2;furin;protecting antigen
Journal Article
Barile, Elisa;Baggio, Carlo;Gambini, Luca;Shiryaev, Sergey A;Strongin, Alex Y;Pellecchia, Maurizio
10.3390/molecules25102424
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming. [Abstract]: Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2') cleavage sites that are pro...
32,426,388
Biomed J
Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor.
Background: The present study demonstrates the potential of flavanoid narcissoside against the novel corona virus (COVID-19) complications using molecular docking studies. Methods: The computation molecular docking screening was performed using Molegro Virtual Docker software (MVD) with grid resolution of 30 A. Protein...
6w63;covid-19;flavonoid;mvd;molecular docking;x77
Journal Article
Dubey, Kushagra;Dubey, Raghvendra
10.1016/j.bj.2020.05.002
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Computation screening of narcissoside a glycosyloxyflavone for potential novel coronavirus 2019 (COVID-19) inhibitor. [Abstract]: Background: The present study demonstrates the potential of flavanoid narcissoside against the novel corona virus (COVID-19) complications using molecular docking studies. Methods: ...
33,062,538
Cureus
Efficacy and Use of Cloth Masks: A Scoping Review.
During the coronavirus disease 2019 (COVID-19) pandemic, there has been a global shortage of personal protective equipment (PPE). In this setting, cloth masks may play an important role in limiting disease transmission; however, current literature on the use of cloth masks remains inconclusive. This review aims to inte...
cloth;coronavirus;covid-19;masks;pandemic;personal protective equipment;ppe;public health
Journal Article;Review
Jain, Mehr;Kim, Sonya T;Xu, Chenchen;Li, Heidi;Rose, Greg
10.7759/cureus.10423
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Efficacy and Use of Cloth Masks: A Scoping Review. [Abstract]: During the coronavirus disease 2019 (COVID-19) pandemic, there has been a global shortage of personal protective equipment (PPE). In this setting, cloth masks may play an important role in limiting disease transmission; however, current literature ...
32,114,745
Zhonghua Nei Ke Za Zhi
[Characteristics of peripheral blood leukocyte differential counts in patients with COVID-19].
To investigate the early changes of peripheral blood leukocyte differential counts in patients with COVID-19. Ten patients with COVID-19 and 30 patients with other viral pneumonia (non-COVID-19) admitted to Shanghai Jiao Tong University Affiliated Sixth People's Hospital and Jinshan Branch Hospital from January 22 to F...
covid-19;eosinophil;viral pneumonia
English Abstract;Journal Article
Li, Y X;Wu, W;Yang, T;Zhou, W;Fu, Y M;Feng, Q M;Ye, J M
3760.10/cma.j.cn112138-20200221-00114
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: [Characteristics of peripheral blood leukocyte differential counts in patients with COVID-19]. [Abstract]: To investigate the early changes of peripheral blood leukocyte differential counts in patients with COVID-19. Ten patients with COVID-19 and 30 patients with other viral pneumonia (non-COVID-19) admitted ...
32,773,182
Crit Care Nurs Clin North Am
Igniting Change: Supporting the Well-Being of Academicians Who Practice and Teach Critical Care.
Academicians who maintain a critical care clinical practice encounter numerous stressors, especially during the COVID-19 pandemic, which can influence well-being. This article provides historical perspectives on the stressors inherent in working in the critical care environment as well as the stressors of working in th...
clinical practice;critical care;critical care nursing;nursing education;nursing faculty;well-being;wellness
Journal Article;Review
Roney, Linda Nancy;Beauvais, Audrey M;Bartos, Susan
10.1016/j.cnc.2020.05.008
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Igniting Change: Supporting the Well-Being of Academicians Who Practice and Teach Critical Care. [Abstract]: Academicians who maintain a critical care clinical practice encounter numerous stressors, especially during the COVID-19 pandemic, which can influence well-being. This article provides historical perspe...
32,864,627
Lancet Rheumatol
Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study.
Background: Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse events associated with its authorisation for emergency use to treat patients with COVID-19 pneumonia. We studied the safety of hydroxychloroquine, alone and in combination with...
Journal Article
Lane, Jennifer C E;Weaver, James;Kostka, Kristin;Duarte-Salles, Talita;Abrahao, Maria Tereza F;Alghoul, Heba;Alser, Osaid;Alshammari, Thamir M;Biedermann, Patricia;Banda, Juan M;Burn, Edward;Casajust, Paula;Conover, Mitchell M;Culhane, Aedin C;Davydov, Alexander;DuVall, Scott L;Dymshyts, Dmitry;Fernandez-Bertolin, Serg...
10.1016/S2665-9913(20)30276-9
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis: a multinational, retrospective study. [Abstract]: Background: Hydroxychloroquine, a drug commonly used in the treatment of rheumatoid arthritis, has received much negative publicity for adverse event...
32,742,318
Exp Ther Med
Interpretable artificial intelligence framework for COVID-19 screening on chest X-rays.
COVID-19 has led to an unprecedented healthcare crisis with millions of infected people across the globe often pushing infrastructures, healthcare workers and entire economies beyond their limits. The scarcity of testing kits, even in developed countries, has led to extensive research efforts towards alternative soluti...
covid-19;chest x-rays;interpretable artificial intelligence;transfer learning
Journal Article
Tsiknakis, Nikos;Trivizakis, Eleftherios;Vassalou, Evangelia E;Papadakis, Georgios Z;Spandidos, Demetrios A;Tsatsakis, Aristidis;Sanchez-Garcia, Jose;Lopez-Gonzalez, Rafael;Papanikolaou, Nikolaos;Karantanas, Apostolos H;Marias, Kostas
10.3892/etm.2020.8797
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Interpretable artificial intelligence framework for COVID-19 screening on chest X-rays. [Abstract]: COVID-19 has led to an unprecedented healthcare crisis with millions of infected people across the globe often pushing infrastructures, healthcare workers and entire economies beyond their limits. The scarcity o...
32,726,792
Stereotact Funct Neurosurg
Gamma Knife Radiosurgery for Treatment of Brain Metastases during the COVID-19 Outbreak.
INTRODUCTION: The WHO declared 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a public health emergency of international concern. The National and Regional Health System has been reorganized, and many oncological patients died during this period or had to interrupt their therapies. This study summari...
brain metastases;covid-19;gamma knife;radiosurgery
Journal Article
Crisa, Francesco Maria;Leocata, Filippo;Arienti, Virginia Maria;Picano, Marco;Berta, Luca;Mainardi, Hae Song;Monti, Angelo Filippo;Musca, Francesco;Colombo, Silvia;Palazzi, Mauro;La Camera, Alessandro
10.1159/000510271
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Gamma Knife Radiosurgery for Treatment of Brain Metastases during the COVID-19 Outbreak. [Abstract]: INTRODUCTION: The WHO declared 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a public health emergency of international concern. The National and Regional Health System has been reorganized,...
33,033,703
Perspect Clin Res
Pharmacovigilance and assessment of drug safety reports during COVID 19.
The speed and volume of clinical research to discover effective drug against novel corona virus has been remarkable. To address the unmet medical need, the regulations are made flexible and convenient without any relaxation in drug safety reporting. The pharmacovigilance activities, especially adverse event reporting r...
covid-19;causality assessment;pharmacovigilance
Journal Article
Desai, Mira K
10.4103/picr.PICR_171_20
[ 1, 0, 1, 0, 0, 0, 0 ]
[Title]: Pharmacovigilance and assessment of drug safety reports during COVID 19. [Abstract]: The speed and volume of clinical research to discover effective drug against novel corona virus has been remarkable. To address the unmet medical need, the regulations are made flexible and convenient without any relaxation in...
32,763,956
RMD Open
Reactive arthritis after COVID-19 infection.
Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection...
arthritis;infectious;reactive
Case Reports;Journal Article
Ono, Keisuke;Kishimoto, Mitsumasa;Shimasaki, Teppei;Uchida, Hiroko;Kurai, Daisuke;Deshpande, Gautam A;Komagata, Yoshinori;Kaname, Shinya
10.1136/rmdopen-2020-001350
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Reactive arthritis after COVID-19 infection. [Abstract]: Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he seve...
32,928,835
BMJ Case Rep
Guillain-Barre syndrome presenting with COVID-19 infection.
A construction worker in his 30s presented three times in 4 days with progressive upper and then lower limb weakness. On the first two occasions he had no systemic symptoms, but on the third presentation he had fever and cough, starting from day 4 of weakness. Examination identified weakness in all four limbs and arefl...
clinical neurophysiology;emergency medicine;infections;influenza;peripheral nerve disease
Case Reports;Journal Article
Ameer, Nasir;Shekhda, Kalyan Mansukhbhai;Cheesman, Ann
10.1136/bcr-2020-236978
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Guillain-Barre syndrome presenting with COVID-19 infection. [Abstract]: A construction worker in his 30s presented three times in 4 days with progressive upper and then lower limb weakness. On the first two occasions he had no systemic symptoms, but on the third presentation he had fever and cough, starting fr...
32,603,901
J Allergy Clin Immunol Pract
SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation.
BACKGROUND: Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is not known. OBJECTIVE: T...
asthma;covid-19;coronavirus;europe;exacerbation;france;sars-cov-2;sars-cov-2 pneumonia
Journal Article
Grandbastien, Manon;Piotin, Anays;Godet, Julien;Abessolo-Amougou, Ines;Ederle, Carole;Enache, Irina;Fraisse, Philippe;Tu Hoang, Thi Cam;Kassegne, Loic;Labani, Aissam;Leyendecker, Pierre;Manien, Louise;Marcot, Christophe;Pamart, Guillaume;Renaud-Picard, Benjamin;Riou, Marianne;Doyen, Virginie;Kessler, Romain;Fafi-Kremer...
10.1016/j.jaip.2020.06.032
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: SARS-CoV-2 Pneumonia in Hospitalized Asthmatic Patients Did Not Induce Severe Exacerbation. [Abstract]: BACKGROUND: Viral infections are known to exacerbate asthma in adults. Previous studies have found few patients with asthma among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia cases....
33,041,632
Annu Rev Control
From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves.
Two mathematical models of the COVID-19 dynamics are considered as the health system in some country consists in a network of regional hospital centers. The first macroscopic model for the virus dynamics at the level of the general population of the country is derived from a standard SIR model. The second local model r...
covid-19;epidemiology;identifiability;identification;observability
Journal Article
Scharbarg, Emeric;Moog, Claude H;Mauduit, Nicolas;Califano, Claudia
10.1016/j.arcontrol.2020.09.007
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves. [Abstract]: Two mathematical models of the COVID-19 dynamics are considered as the health system in some country consists in a network of regional hospital centers. The first macroscopic model for...
32,826,334
Proc Natl Acad Sci U S A
Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates.
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now undergoing extensive scrutiny to understand the routes of transmission and sensitivity in different species. Here, we utilized a ...
ace2;covid-19;sars-cov-2;comparative genomics;species conservation
Comparative Study;Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Damas, Joana;Hughes, Graham M;Keough, Kathleen C;Painter, Corrie A;Persky, Nicole S;Corbo, Marco;Hiller, Michael;Koepfli, Klaus-Peter;Pfenning, Andreas R;Zhao, Huabin;Genereux, Diane P;Swofford, Ross;Pollard, Katherine S;Ryder, Oliver A;Nweeia, Martin T;Lindblad-Toh, Kerstin;Teeling, Emma C;Karlsson, Elinor K;Lewin, Ha...
10.1073/pnas.2010146117
[ 0, 0, 0, 1, 1, 0, 0 ]
[Title]: Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates. [Abstract]: The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 (ACE2), is now unde...
32,792,288
Paediatr Respir Rev
Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19.
The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated host immune res...
children;immune dysregulation;multi-system inflammatory syndrome [mis-c];sars-cov-2;treatment
Journal Article;Review
Tanner, Tamara;Wahezi, Dawn M
10.1016/j.prrv.2020.07.003
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19. [Abstract]: The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is a...
32,623,963
Emerg Microbes Infect
Advances in detection of infectious agents by aptamer-based technologies.
Infectious diseases still remain one of the biggest challenges for human health. Accurate and early detection of infectious pathogens are crucial for transmission control, clinical diagnosis, and therapy. For a traditional reason, most immunological and microbiological laboratories are equipped with instruments designa...
aptamer;hbv;hcv;hiv;amoeba;leishmania;tuberculosis
Journal Article;Review
Li, Hui-Yan;Jia, Wan-Nan;Li, Xin-Yi;Zhang, Li;Liu, Chang;Wu, Jian
10.1080/22221751.2020.1792352
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Advances in detection of infectious agents by aptamer-based technologies. [Abstract]: Infectious diseases still remain one of the biggest challenges for human health. Accurate and early detection of infectious pathogens are crucial for transmission control, clinical diagnosis, and therapy. For a traditional re...
32,979,586
Int J Infect Dis
Maintaining robust HIV and tuberculosis services in the COVID-19 era: A public health dilemma in Zimbabwe.
Coronavirus disease 2019 (COVID-19) has challenged health systems worldwide. In Zimbabwe, the COVID-19 response has seen the diversion of human capital, equipment, and other resources that were meant for the HIV and tuberculosis (TB) programmes. In a country with one of the worst HIV and TB burdens globally, the author...
covid-19;hiv;pandemic;tuberculosis;zimbabwe
Journal Article
Mukwenha, Solomon;Dzinamarira, Tafadzwa;Mugurungi, Owen;Musuka, Godfrey
10.1016/j.ijid.2020.09.1425
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Maintaining robust HIV and tuberculosis services in the COVID-19 era: A public health dilemma in Zimbabwe. [Abstract]: Coronavirus disease 2019 (COVID-19) has challenged health systems worldwide. In Zimbabwe, the COVID-19 response has seen the diversion of human capital, equipment, and other resources that wer...
32,703,908
Science
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we report a humanized monoclonal antibody, H014, that efficiently neut...
Journal Article;Research Support, Non-U.S. Gov't
Lv, Zhe;Deng, Yong-Qiang;Ye, Qing;Cao, Lei;Sun, Chun-Yun;Fan, Changfa;Huang, Weijin;Sun, Shihui;Sun, Yao;Zhu, Ling;Chen, Qi;Wang, Nan;Nie, Jianhui;Cui, Zhen;Zhu, Dandan;Shaw, Neil;Li, Xiao-Feng;Li, Qianqian;Xie, Liangzhi;Wang, Youchun;Rao, Zihe;Qin, Cheng-Feng;Wang, Xiangxi
10.1126/science.abc5881
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody. [Abstract]: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vacci...
32,451,657
Int Orthop
Impact of the COVID-19 pandemic on patients suffering from musculoskeletal tumours.
BACKGROUND: The aim of the current study was to evaluate the impact of the coronavirus disease (COVID-19) pandemic on musculoskeletal tumor service by conducting an online survey of physicians. METHODS: The survey was conducted among the members of the ISOLS (International Society of Limb Salvage) and the EMSOS (Europe...
covid-19;healthcare;musculoskeletal tumor;oncology;pandemic;sars-cov-2;sarcoma;severe acute respiratory syndrome coronavirus 2
Journal Article
Thaler, Martin;Khosravi, Ismail;Leithner, Andreas;Papagelopoulos, Panayiotis J;Ruggieri, Pietro
10.1007/s00264-020-04636-4
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Impact of the COVID-19 pandemic on patients suffering from musculoskeletal tumours. [Abstract]: BACKGROUND: The aim of the current study was to evaluate the impact of the coronavirus disease (COVID-19) pandemic on musculoskeletal tumor service by conducting an online survey of physicians. METHODS: The survey w...
32,993,656
Respir Res
Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics.
SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract are incompletely characterized. We analyzed publicly available RNA microarray datasets for SARS-CoV-2 entry receptors and cofactors AC...
ace-2;asthma;basigin;covid-19;coronavirus;furin;respiratory epithelium;sars-cov-2;smoking;tmprss2
Comparative Study;Letter;Review
Matusiak, Magdalena;Schurch, Christian M
10.1186/s12931-020-01521-x
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics. [Abstract]: SARS-CoV-2 is causing a pandemic with currently > 29 million confirmed cases and > 900,000 deaths worldwide. The locations and mechanisms of virus entry into the human respiratory tract...
33,022,076
J Cell Physiol
Immunobiology and immunotherapy of COVID-19: A clinically updated overview.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVID-19). COVID-9 has become a global pandemic with severe health issues around the world. Identifying the accurate immunopathogenesis of the COVID-19 and the immune response ...
covid-19;sars-cov-2;clinical trial;immunopathogenesis;immunotherapy
Journal Article;Review
Esmaeilzadeh, Abdolreza;Elahi, Reza
10.1002/jcp.30076
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Immunobiology and immunotherapy of COVID-19: A clinically updated overview. [Abstract]: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVID-19). COVID-9 has become a global pandemic with severe health issues aroun...
32,834,593
Chaos Solitons Fractals
Analysis of a mathematical model for COVID-19 population dynamics in Lagos, Nigeria.
This work examines the impact of various non-pharmaceutical control measures (government and personal) on the population dynamics of the novel coronavirus disease 2019 (COVID-19) in Lagos, Nigeria, using an appropriately formulated mathematical model. Using the available data, since its first reported case on 16 March ...
covid-19;case-detection;face-mask;model-fitting;simulations;social distancing
Journal Article
Okuonghae, D;Omame, A
10.1016/j.chaos.2020.110032
[ 0, 0, 1, 0, 0, 1, 0 ]
[Title]: Analysis of a mathematical model for COVID-19 population dynamics in Lagos, Nigeria. [Abstract]: This work examines the impact of various non-pharmaceutical control measures (government and personal) on the population dynamics of the novel coronavirus disease 2019 (COVID-19) in Lagos, Nigeria, using an appropr...
32,879,035
Respir Care
Re-Examining the Race to Send Ventilators to Low-Resource Settings.
COVID-19 is devastating health systems globally and causing severe ventilator shortages. Since the beginning of the outbreak, the provision and use of ventilators has been a key focus of public discourse. Scientists and engineers from leading universities and companies have rushed to develop low-cost ventilators in hop...
covid-19;cost effectiveness;global health;low-resource settings;mechanical ventilation;resource allocation
Journal Article;Review
Mantena, Sreekar;Rogo, Khama;Burke, Thomas F
10.4187/respcare.08185
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Re-Examining the Race to Send Ventilators to Low-Resource Settings. [Abstract]: COVID-19 is devastating health systems globally and causing severe ventilator shortages. Since the beginning of the outbreak, the provision and use of ventilators has been a key focus of public discourse. Scientists and engineers f...
32,427,157
J Am Coll Emerg Physicians Open
Coronavirus disease 2019: International public health considerations.
On December 31, 2019, the Chinese government announced an outbreak of a novel coronavirus, recently named COVID-19. During the following weeks the international medical community has witnessed with unprecedented coverage the public health response both domestically by the Chinese government, and on an international sca...
Journal Article;Review
Greene, Christopher J;Burleson, Samuel L;Crosby, James C;Heimann, Matthew A;Pigott, David C
10.1002/emp2.12040
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Coronavirus disease 2019: International public health considerations. [Abstract]: On December 31, 2019, the Chinese government announced an outbreak of a novel coronavirus, recently named COVID-19. During the following weeks the international medical community has witnessed with unprecedented coverage the publ...
32,903,841
Front Public Health
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis.
Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of ...
covid-19;d-dimer;sars-cov-2;coagulation;thrombosis
Systematic Review
Paliogiannis, Panagiotis;Mangoni, Arduino Aleksander;Dettori, Paola;Nasrallah, Gheyath K;Pintus, Gianfranco;Zinellu, Angelo
10.3389/fpubh.2020.00432
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis. [Abstract]: Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all c...
32,293,168
ACS Nano
Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor.
Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously called 2019-nCoV). Based on the rapid increase in the rate of human infection, the World Health Organization (WHO) has classified the COVID-19 outbreak as a ...
2019-ncov;covid-19;fet;sars-cov-2;biosensor
Journal Article;Research Support, Non-U.S. Gov't
Seo, Giwan;Lee, Geonhee;Kim, Mi Jeong;Baek, Seung-Hwa;Choi, Minsuk;Ku, Keun Bon;Lee, Chang-Seop;Jun, Sangmi;Park, Daeui;Kim, Hong Gi;Kim, Seong-Jun;Lee, Jeong-O;Kim, Bum Tae;Park, Edmond Changkyun;Kim, Seung Il
10.1021/acsnano.0c02823
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor. [Abstract]: Coronavirus disease 2019 (COVID-19) is a newly emerging human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, prev...
32,827,214
J Gerontol B Psychol Sci Soc Sci
Dementia Caregiving During the "Stay-at-Home" Phase of COVID-19 Pandemic.
OBJECTIVE: Assess family caregivers' primary appraisal of stressors related to COVID-19 stay-at-home orders, secondary appraisal of resources and support availability, and use of coping strategies as predictors of perceived role overload during the stay-at-home phase of the pandemic. METHOD: Telephone interviews with 5...
family caregivers;memory loss;rural;stress
Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Savla, Jyoti;Roberto, Karen A;Blieszner, Rosemary;McCann, Brandy Renee;Hoyt, Emily;Knight, Aubrey L
10.1093/geronb/gbaa129
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Dementia Caregiving During the "Stay-at-Home" Phase of COVID-19 Pandemic. [Abstract]: OBJECTIVE: Assess family caregivers' primary appraisal of stressors related to COVID-19 stay-at-home orders, secondary appraisal of resources and support availability, and use of coping strategies as predictors of perceived r...
32,835,459
Am J Manag Care
Chronic disease management in the COVID-19 era.
In the coronavirus disease 2019 (COVID-19) era, clinical registries and innovative virtual care delivery tools should be leveraged to engage populations in effective chronic disease management.
Journal Article
Mirsky, Jacob B;Horn, Daniel M
10.37765/ajmc.2020.43838
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Chronic disease management in the COVID-19 era. [Abstract]: In the coronavirus disease 2019 (COVID-19) era, clinical registries and innovative virtual care delivery tools should be leveraged to engage populations in effective chronic disease management. [Keywords]:
32,807,934
Nat Med
A dynamic COVID-19 immune signature includes associations with poor prognosis.
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly he...
Journal Article;Research Support, Non-U.S. Gov't
Laing, Adam G;Lorenc, Anna;Del Molino Del Barrio, Irene;Das, Abhishek;Fish, Matthew;Monin, Leticia;Munoz-Ruiz, Miguel;McKenzie, Duncan R;Hayday, Thomas S;Francos-Quijorna, Isaac;Kamdar, Shraddha;Joseph, Magdalene;Davies, Daniel;Davis, Richard;Jennings, Aislinn;Zlatareva, Iva;Vantourout, Pierre;Wu, Yin;Sofra, Vasiliki;C...
10.1038/s41591-020-1038-6
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: A dynamic COVID-19 immune signature includes associations with poor prognosis. [Abstract]: Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral b...
33,033,248
Nat Commun
Two distinct immunopathological profiles in autopsy lungs of COVID-19.
Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remai...
Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Nienhold, Ronny;Ciani, Yari;Koelzer, Viktor H;Tzankov, Alexandar;Haslbauer, Jasmin D;Menter, Thomas;Schwab, Nathalie;Henkel, Maurice;Frank, Angela;Zsikla, Veronika;Willi, Niels;Kempf, Werner;Hoyler, Thomas;Barbareschi, Mattia;Moch, Holger;Tolnay, Markus;Cathomas, Gieri;Demichelis, Francesca;Junt, Tobias;Mertz, Kirsten ...
10.1038/s41467-020-18854-2
[ 1, 1, 0, 1, 0, 0, 0 ]
[Title]: Two distinct immunopathological profiles in autopsy lungs of COVID-19. [Abstract]: Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has be...
32,292,232
Med J Armed Forces India
Healthcare impact of COVID-19 epidemic in India: A stochastic mathematical model.
Background: In India, the SARS-CoV-2 COVID-19 epidemic has grown to 1251 cases and 32 deaths as on 30 Mar 2020. The healthcare impact of the epidemic in India was studied using a stochastic mathematical model. Methods: A compartmental SEIR model was developed, in which the flow of individuals through compartments is mo...
covid-19;coronavirus;epidemiology;models;quarantine;sars-cov-2;theoretical
Journal Article
Chatterjee, Kaustuv;Chatterjee, Kaushik;Kumar, Arun;Shankar, Subramanian
10.1016/j.mjafi.2020.03.022
[ 0, 0, 1, 0, 0, 1, 0 ]
[Title]: Healthcare impact of COVID-19 epidemic in India: A stochastic mathematical model. [Abstract]: Background: In India, the SARS-CoV-2 COVID-19 epidemic has grown to 1251 cases and 32 deaths as on 30 Mar 2020. The healthcare impact of the epidemic in India was studied using a stochastic mathematical model. Methods...
32,495,288
Front Med
Linking key intervention timings to rapid declining effective reproduction number to quantify lessons against COVID-19.
Coronavirus disease 2019 (COVID-19) is currently under a global pandemic trend. The efficiency of containment measures and epidemic tendency of typical countries should be assessed. In this study, the efficiency of prevention and control measures in China, Italy, Iran, South Korea, and Japan was assessed, and the COVID...
covid-19;chinese experience;epidemic control comparison
Journal Article
Peng, Zhihang;Song, Wenyu;Ding, Zhongxing;Guan, Quanquan;Yang, Xu;Xu, Qiaoqiao;Wang, Xu;Xia, Yankai
10.1007/s11684-020-0788-3
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Linking key intervention timings to rapid declining effective reproduction number to quantify lessons against COVID-19. [Abstract]: Coronavirus disease 2019 (COVID-19) is currently under a global pandemic trend. The efficiency of containment measures and epidemic tendency of typical countries should be assesse...
32,828,864
J Hosp Infect
Environmental contamination in the isolation rooms of COVID-19 patients with severe pneumonia requiring mechanical ventilation or high-flow oxygen therapy.
BACKGROUND: Identifying the extent of environmental contamination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential for infection control and prevention. The extent of environmental contamination has not been fully investigated in the context of severe coronavirus disease (COVID-19) patients....
covid-19;environmental contamination;sars-cov-2;severe pneumonia
Journal Article
Ahn, J Y;An, S;Sohn, Y;Cho, Y;Hyun, J H;Baek, Y J;Kim, M H;Jeong, S J;Kim, J H;Ku, N S;Yeom, J-S;Smith, D M;Lee, H;Yong, D;Lee, Y-J;Kim, J W;Kim, H R;Hwang, J;Choi, J Y
10.1016/j.jhin.2020.08.014
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Environmental contamination in the isolation rooms of COVID-19 patients with severe pneumonia requiring mechanical ventilation or high-flow oxygen therapy. [Abstract]: BACKGROUND: Identifying the extent of environmental contamination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential ...
32,520,514
Clin Nucl Med
Incidental COVID-19 Pneumonia on 18F-Fluorocholine PET/CT.
We present the case of a patient who underwent F-fluorocholine PET/CT for biochemical recurrence of prostate cancer in which bilateral pneumonia was diagnosed. In the current state of COVID-19 pandemic, a high prevalence of incidental pneumonia may be expected, even with previous clinical triage, explained by a nondefi...
Case Reports;Journal Article
Garcia Vicente, Ana Maria;Soriano Castrejon, Angel
10.1097/RLU.0000000000003189
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: Incidental COVID-19 Pneumonia on 18F-Fluorocholine PET/CT. [Abstract]: We present the case of a patient who underwent F-fluorocholine PET/CT for biochemical recurrence of prostate cancer in which bilateral pneumonia was diagnosed. In the current state of COVID-19 pandemic, a high prevalence of incidental pneum...
33,060,835
Genet Med
Individuals with Down syndrome hospitalized with COVID-19 have more severe disease.
PURPOSE: Rare genetic conditions like Down syndrome (DS) are historically understudied. Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is unknown how the COVID-19 pandemic affects individuals with DS. Herein, we report an analysis of individuals with DS who were hospitalize...
covid-19;down syndrome;sars-cov-2;primary immunodeficiency;trisomy 21
Journal Article;Research Support, N.I.H., Extramural
Malle, Louise;Gao, Cynthia;Hur, Chin;Truong, Han Q;Bouvier, Nicole M;Percha, Bethany;Kong, Xiao-Fei;Bogunovic, Dusan
10.1038/s41436-020-01004-w
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: Individuals with Down syndrome hospitalized with COVID-19 have more severe disease. [Abstract]: PURPOSE: Rare genetic conditions like Down syndrome (DS) are historically understudied. Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is unknown how the COVID-19 pandem...
32,844,302
Pulm Ther
The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review.
The novel coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide socio-economic and health impact. There is increasing evidence that a combination of inflammation and hypercoagulable state are the main mechanisms of respiratory failure in these patients. This narrative review aims to summarize cu...
anti-coagulation;anti-inflammatory;covid-19;immune dysregulation;thrombosis
Journal Article;Review
Bhattacharyya, Rajat;Iyer, Prasad;Phua, Ghee Chee;Lee, Jan Hau
10.1007/s41030-020-00126-5
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review. [Abstract]: The novel coronavirus disease (COVID-19) pandemic has caused an unprecedented worldwide socio-economic and health impact. There is increasing evidence that a combination of in...
32,422,305
Life Sci
Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment.
COVID-19 pandemic has a high mortality rate and is affecting practically the entire world population. The leading cause of death is severe acute respiratory syndrome as a consequence of exacerbated inflammatory response accompanied by uncontrolled oxidative stress as well as the inflammatory reaction at the lung level....
covid-19;inflammation;melatonin;oxidation;renin-angiotensin system;vitamin d
Journal Article;Review
Martin Gimenez, Virna Margarita;Inserra, Felipe;Tajer, Carlos D;Mariani, Javier;Ferder, Leon;Reiter, Russel J;Manucha, Walter
10.1016/j.lfs.2020.117808
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment. [Abstract]: COVID-19 pandemic has a high mortality rate and is affecting practically the entire world population. The leading cause of death is severe acute respira...
32,730,380
Rev Med Chil
[With regard to COVID-19 contingency. ECMO in adults. Extracorporeal Membrane Oxygenation). To whom, how and when].
ECMO (Extracorporeal Membrane Oxygenation) is an extracorporeal life support system in catastrophic lung failure, shock and cardiopulmonary resuscitation, in different age groups, with multiple physiologic features. When the candidate to be submitted is too unstable to be transported to a hospital with ECMO, cannulatio...
Journal Article;Review
Diaz, Rodrigo;Antonini, Marta Velia;Orrego, Rodrigo;Abrams, Darryl
10.4067/S0034-98872020000300349
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: [With regard to COVID-19 contingency. ECMO in adults. Extracorporeal Membrane Oxygenation). To whom, how and when]. [Abstract]: ECMO (Extracorporeal Membrane Oxygenation) is an extracorporeal life support system in catastrophic lung failure, shock and cardiopulmonary resuscitation, in different age groups, wit...
32,174,129
AJR Am J Roentgenol
Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients.
OBJECTIVE. Available information on CT features of the 2019 novel coronavirus disease (COVID-19) is scattered in different publications, and a cohesive literature review has yet to be compiled. MATERIALS AND METHODS. This article includes a systematic literature search of PubMed, Embase (Elsevier), Google Scholar, and ...
2019-ncov;covid-19;ct scan;coronavirus;influenza;outbreak;pneumonia;radiology;systematic review;viral
Journal Article;Systematic Review
Salehi, Sana;Abedi, Aidin;Balakrishnan, Sudheer;Gholamrezanezhad, Ali
10.2214/AJR.20.23034
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. [Abstract]: OBJECTIVE. Available information on CT features of the 2019 novel coronavirus disease (COVID-19) is scattered in different publications, and a cohesive literature review has yet to be compiled. MATERIALS A...
32,984,666
Infect Dis Model
Modeling Palestinian COVID-19 Cumulative Confirmed Cases: A Comparative Study.
COVID-19 is still a major pandemic threatening all the world. In Palestine, there were 26,764 COVID-19 cumulative confirmed cases as of 27th August 2020. In this paper, two statistical approaches, autoregressive integrated moving average (ARIMA) and k-th moving averages - ARIMA models are used for modeling the COVID-19...
arima models;covid-19;forecasting;moving average models;pandemic
Journal Article
Dawoud, Issam
10.1016/j.idm.2020.09.001
[ 0, 0, 1, 0, 0, 1, 0 ]
[Title]: Modeling Palestinian COVID-19 Cumulative Confirmed Cases: A Comparative Study. [Abstract]: COVID-19 is still a major pandemic threatening all the world. In Palestine, there were 26,764 COVID-19 cumulative confirmed cases as of 27th August 2020. In this paper, two statistical approaches, autoregressive integrat...
32,396,922
Nature
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2.
An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 2019(1,2). Following an unprecedented global spread(3), the World Health Organization declared COVID-19 a pandemic on 11 Ma...
Journal Article;Research Support, N.I.H., Intramural
Munster, Vincent J;Feldmann, Friederike;Williamson, Brandi N;van Doremalen, Neeltje;Perez-Perez, Lizzette;Schulz, Jonathan;Meade-White, Kimberly;Okumura, Atsushi;Callison, Julie;Brumbaugh, Beniah;Avanzato, Victoria A;Rosenke, Rebecca;Hanley, Patrick W;Saturday, Greg;Scott, Dana;Fischer, Elizabeth R;de Wit, Emmie
10.1038/s41586-020-2324-7
[ 0, 0, 0, 1, 0, 0, 0 ]
[Title]: Respiratory disease in rhesus macaques inoculated with SARS-CoV-2. [Abstract]: An outbreak of coronavirus disease 2019 (COVID-19), which is caused by a novel coronavirus (named SARS-CoV-2) and has a case fatality rate of approximately 2%, started in Wuhan (China) in December 2019(1,2). Following an unprecedent...
32,705,222
Mol Med Rep
Clinical characteristics of 2019 novel coronavirus pneumonia in Zhejiang province, China.
Since December 2019, an increasing number of cases associated with the 2019 novel coronavirus (2019nCoV) have emerged in Wuhan, China, which has resulted in a rapid outbreak in China and worldwide. The present study aimed to describe the clinical, laboratory and radiological characteristics of 2019nCoV pneumonia (NCP) ...
Journal Article
Chen, Ling;Jin, Qiuhong;Zhou, Ying;Yang, Jiao;Wang, Zhehua;Ge, Ke;Yang, Jiangle;Wang, Hong
10.3892/mmr.2020.11329
[ 0, 1, 0, 0, 0, 0, 0 ]
[Title]: Clinical characteristics of 2019 novel coronavirus pneumonia in Zhejiang province, China. [Abstract]: Since December 2019, an increasing number of cases associated with the 2019 novel coronavirus (2019nCoV) have emerged in Wuhan, China, which has resulted in a rapid outbreak in China and worldwide. The present...
32,336,467
Cir Esp
SARS-CoV-2 pandemic on the activity and professionals of a General Surgery and Digestive Surgery Service in a tertiary hospital.
INTRODUCTION: The rapid spread of SARS-CoV-2 infection has led to a radical reorganization of healthcare resources. Surgical Departments need to adapt to this change. METHODS: We performed a prospective descriptive observational study of the incidence of COVID-19 in patients and surgeons of a General Surgical Departmen...
covid-19;cirugia;enfermedades infecciosas;healthcare personnel;infectious diseases;personal sanitario;surgery
Journal Article;Observational Study
Alvarez Gallego, Mario;Gortazar de Las Casas, Sara;Pascual Miguelanez, Isabel;Rubio-Perez, Ines;Barragan Serrano, Cristina;Alvarez Pena, Estibaliz;Diaz Dominguez, Joaquin
10.1016/j.ciresp.2020.04.001
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: SARS-CoV-2 pandemic on the activity and professionals of a General Surgery and Digestive Surgery Service in a tertiary hospital. [Abstract]: INTRODUCTION: The rapid spread of SARS-CoV-2 infection has led to a radical reorganization of healthcare resources. Surgical Departments need to adapt to this change. MET...
32,489,692
Aging Dis
Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease.
A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease 2019 (COVID-19). These outcomes displayed that intravenous infiltration of MSCs is a safe and efficacy treatment for COVID-19 pneumonia, a...
adipocyte secreted exosomal microrna;covid-19;adipose derived stem cells;coronavirus;mesenchymal stem cells
Editorial
Gentile, Pietro;Sterodimas, Aris
10.14336/AD.2020.0422
[ 1, 0, 0, 0, 0, 0, 0 ]
[Title]: Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease. [Abstract]: A recent and interesting study reported improved respiratory activity after intravenous administration of mesenchymal stem cells (MSCs) into patients affected by coronavirus disease...
32,970,989
Cell
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2.
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the ACE2-binding site. Both ACE2 and heparin can bind independently to spike...
covid-19;sars-cov-2;coronavirus;heparan sulfate;heparan sulfate-binding proteins;heparin;lung epithelial cells;pseudotyped virus;spike proteins
Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Clausen, Thomas Mandel;Sandoval, Daniel R;Spliid, Charlotte B;Pihl, Jessica;Perrett, Hailee R;Painter, Chelsea D;Narayanan, Anoop;Majowicz, Sydney A;Kwong, Elizabeth M;McVicar, Rachael N;Thacker, Bryan E;Glass, Charles A;Yang, Zhang;Torres, Jonathan L;Golden, Gregory J;Bartels, Phillip L;Porell, Ryan N;Garretson, Aaron...
10.1016/j.cell.2020.09.033
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. [Abstract]: We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site ...
32,766,815
Clin Infect Dis
COVID-19 in solid organ transplant: A multi-center cohort study.
BACKGROUND: The COVID-19 pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features, outcomes, and predictors of mortality in SOT recipients are not well-described. METHO...
covid-19;sars-cov-2;coronavirus;solid organ transplantation;transplantation
Journal Article
Kates, Olivia S;Haydel, Brandy M;Florman, Sander S;Rana, Meenakshi M;Chaudhry, Zohra S;Ramesh, Mayur S;Safa, Kassem;Kotton, Camille Nelson;Blumberg, Emily A;Besharatian, Behdad D;Tanna, Sajal D;Ison, Michael G;Malinis, Maricar;Azar, Marwan M;Rakita, Robert M;Morillas, Jose A;Majeed, Aneela;Sait, Afrah S;Spaggiari, Mari...
10.1093/cid/ciaa1097
[ 1, 1, 0, 0, 0, 0, 0 ]
[Title]: COVID-19 in solid organ transplant: A multi-center cohort study. [Abstract]: BACKGROUND: The COVID-19 pandemic has led to significant reductions in transplantation, motivated in part by concerns of disproportionately more severe disease among solid organ transplant (SOT) recipients. However, clinical features,...
32,734,636
J Surg Oncol
Low-cost, safe, and effective smoke evacuation device for surgical procedures in the COVID-19 age.
BACKGROUND: Smoke is generated by energy-based surgical instruments. The airborne by-products may have potential health implications. METHODS: We developed a simple way to use de conventional surgical evacuator coupled with de electrosurgical pen attached to a 14G bladder catheter for open surgery. It was used in ten p...
covid-19;breast surgery;smoke evacuation device;smoke in surgery;surgical smoke
Journal Article
Andrade, Wesley Pereira;Goncalves, Graziella Galvao;Medeiros, Luciana Cortelazzi;Araujo, Danielle Cristina Miyamoto;Pereira, Gisele Tolaini Gomes;Moraes, Daniela Martins Pereira;Spencer, Ranyell M S S B
10.1002/jso.26133
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Low-cost, safe, and effective smoke evacuation device for surgical procedures in the COVID-19 age. [Abstract]: BACKGROUND: Smoke is generated by energy-based surgical instruments. The airborne by-products may have potential health implications. METHODS: We developed a simple way to use de conventional surgical...
32,599,669
Child Adolesc Ment Health
Debate: COVID-19 and children in India.
The COVID-19 pandemic impact on children is a growing concern. The United Nations and its agencies (the World Health Organization and UNICEF), Indian Association For Child and Adolescent Mental Health and National Institute of Mental Health and Neuroscience in India warn about the broader impacts on children and call f...
covid-19;india;children;mental health;pandemic
Journal Article
Kumar, Anant;Nayar, K Rajasekharan;Bhat, Lekha D
10.1111/camh.12398
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Debate: COVID-19 and children in India. [Abstract]: The COVID-19 pandemic impact on children is a growing concern. The United Nations and its agencies (the World Health Organization and UNICEF), Indian Association For Child and Adolescent Mental Health and National Institute of Mental Health and Neuroscience i...
32,999,267
Am J Case Rep
A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia.
BACKGROUND Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, in late 2019 and has led to an ongoing pandemic. COVID-19 typically affects the respiratory tract and mucous membranes, leading to pathological involvement of vario...
Case Reports;Journal Article
Adekiigbe, Riliwan;Ugbode, Franklin;Seoparson, Sunil;Katriyar, Neeraj;Fetterman, Alan
10.12659/AJCR.926886
[ 0, 0, 0, 0, 0, 0, 1 ]
[Title]: A 47-Year-Old Hispanic Man Who Developed Cutaneous Vasculitic Lesions and Gangrene of the Toes Following Admission to Hospital with COVID-19 Pneumonia. [Abstract]: BACKGROUND Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan...
32,772,540
Am Psychol
Religion and reactance to COVID-19 mitigation guidelines.
During the current COVID-19 pandemic, religious gatherings have become intense hot spots for the spread of the virus. In this research, we focus on the religiosity of communities to examine whether religiosity helps or hinders adherence to mitigation policies such as shelter-in-place directives. Prior research has made...
Journal Article
DeFranza, David;Lindow, Mike;Harrison, Kevin;Mishra, Arul;Mishra, Himanshu
10.1037/amp0000717
[ 0, 0, 1, 0, 0, 0, 0 ]
[Title]: Religion and reactance to COVID-19 mitigation guidelines. [Abstract]: During the current COVID-19 pandemic, religious gatherings have become intense hot spots for the spread of the virus. In this research, we focus on the religiosity of communities to examine whether religiosity helps or hinders adherence to m...
32,872,736
Korean J Intern Med
Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea.
Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angiotensin-aldosterone system (RAAS) inhibitors and the risk and severity of COVID-19. Methods: We performed a case-control study that utilized up-to-date data ...
ace inhibitor;arb;covid-19;raas inhibitor;hypertension
Journal Article;Observational Study
Seo, Jeongkuk;Son, Minkook
10.3904/kjim.2020.380
[ 1, 0, 0, 1, 0, 0, 0 ]
[Title]: Update on association between exposure to renin-angiotensin-aldosterone system inhibitors and coronavirus disease 2019 in South Korea. [Abstract]: Background/Aims: Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, there have been concerns about the association between exposure to renin-angio...