id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
118,548,836
O=C(N[C@H](Cc1cc(F)cc(F)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cl)c(C(F)(F)F)c1
NCC1CCC(C(F)F)CC1
O=C(N[Dy])[C@@H](Cc1cc(F)cc(F)c1)Nc1nc(NCC2CCC(C(F)F)CC2)nc(Nc2ccc(Cl)c(C(F)(F)F)c2)n1
sEH
1
47,619,796
Cc1cc(Br)c(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
NCCCCN1CCCC1
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
Cc1cc(Br)c(C(=O)N[Dy])cc1Nc1nc(NCCCCN2CCCC2)nc(Nc2n[nH]c3c(Cl)cc([N+](=O)[O-])cc23)n1
HSA
1
82,097,714
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(F)c(N)c1
COC(=O)c1cc(Cl)nc(Cl)c1N
COC(=O)c1cc(Cl)nc(Cl)c1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cc(C)ccc2F)n1
sEH
1
37,806,610
COc1ccc([C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
NCCC1CSC1
Cl.Cl.NCCc1nc2c(s1)COCC2
COc1ccc([C@H](Nc2nc(NCCc3nc4c(s3)COCC4)nc(NCCC3CSC3)n2)C(=O)N[Dy])cc1
HSA
1
82,806,422
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
C=C(Cl)CN.Cl
Nc1nc2ccccc2o1
C=C(Cl)CNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2nc3ccccc3o2)n1
sEH
1
126,240,459
O=C(N[C@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCCC2=O
COc1cc(CN)sn1.Cl.Cl
COc1cc(CNc2nc(Nc3ccc4c(c3)CCCC4=O)nc(N[C@H](Cc3ccc([N+](=O)[O-])cc3)C(=O)N[Dy])n2)sn1
BRD4
1
18,321,621
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccc(CC2COC(=O)N2)cc1
Cc1ccc(CN)c(OC2CCOC2)c1
Cc1ccc(CNc2nc(Nc3ccc(CC4COC(=O)N4)cc3)nc(NC(CC(C)C)C(=O)N[Dy])n2)c(OC2CCOC2)c1
BRD4
1
81,895,139
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1OC
Cl.Cl.NCC(O)c1ccncc1
COC(=O)c1ccc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC(O)c3ccncc3)n2)cc1OC
sEH
1
72,622,242
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
N#Cc1ccnc(N)c1
CC(C)(C#N)c1ccc(N)cc1
CC(C)(C#N)c1ccc(Nc2nc(Nc3cc(C#N)ccn3)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)cc1
BRD4
1
82,444,337
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCC1(Cc2ccccc2)CC1
NCc1nc(-c2ccsc2)no1
O=C(N[Dy])C1CCC(CNc2nc(NCc3nc(-c4ccsc4)no3)nc(NCC3(Cc4ccccc4)CC3)n2)CC1
sEH
1
82,203,155
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(-n2cncn2)cc1
Nc1cc(-c2cccc(Br)c2)no1
O=C(N[Dy])C1CCC(CNc2nc(NCc3ccc(-n4cncn4)cc3)nc(Nc3cc(-c4cccc(Br)c4)no3)n2)CC1
sEH
1
126,602,009
O=C(N[C@H](Cc1ccccc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
COCc1ccccc1CN
Cl.NCCN1C(=O)SC(=Cc2cccs2)C1=O
COCc1ccccc1CNc1nc(NCCN2C(=O)SC(=Cc3cccs3)C2=O)nc(N[C@H](Cc2ccccc2Cl)C(=O)N[Dy])n1
sEH
1
249,815,350
O=C(O)C[C@@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1[nH][nH]c(=O)c1CCN
Nc1n[nH]c2ccc([N+](=O)[O-])cc12
Cc1[nH][nH]c(=O)c1CCNc1nc(Nc2n[nH]c3ccc([N+](=O)[O-])cc23)nc(N[C@@H](CC(=O)N[Dy])Cc2ccc(I)cc2)n1
HSA
1
127,715,211
O=C(N[C@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cc(N)ccn1
Nc1c(O)ncnc1O
COc1cc(Nc2nc(Nc3c(O)ncnc3O)nc(N[C@H](Cc3csc4ccccc34)C(=O)N[Dy])n2)ccn1
BRD4
1
82,521,779
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1cccc2c1OCO2
CC12CCC(CN)(C1)OC2.Cl
CC12CCC(CNc3nc(NCc4cccc5c4OCO5)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)(C1)OC2
sEH
1
217,102,406
O=C(Nc1cccnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1cncc(N)c1
N#Cc1nc[nH]c1N
COc1cncc(Nc2nc(Nc3cccnc3C(=O)N[Dy])nc(Nc3[nH]cnc3C#N)n2)c1
sEH
1
207,175,174
O=C(Nc1cccc(-c2cccc(C(=O)O)c2)c1O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(F)c(F)cc1N
Nc1nc(=O)[nH]cc1Br
COC(=O)c1cc(F)c(F)cc1Nc1nc(Nc2cccc(-c3cccc(C(=O)N[Dy])c3)c2O)nc(Nc2nc(=O)[nH]cc2Br)n1
HSA
1
82,304,645
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCCCN1C(=O)CCC1=O
NCC1CCCCC(F)(F)C1
O=C(N[Dy])C1CCC(CNc2nc(NCCCN3C(=O)CCC3=O)nc(NCC3CCCCC(F)(F)C3)n2)CC1
sEH
1
164,997,265
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
NCc1cn2cccc(F)c2n1
O=C(N[Dy])c1ccc(C(=O)O)c(Nc2nc(NCc3cn4cccc(F)c4n3)nc(NC[C@@H]3CCO[C@H]3c3cn[nH]c3)n2)c1
HSA
1
82,969,151
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(F)c(F)cc1N
Nc1n[nH]c2cc(Cl)ccc12
COC(=O)c1cc(F)c(F)cc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2n[nH]c3cc(Cl)ccc23)n1
sEH
1
231,072,661
O=C(Nc1ncc(C(=O)O)s1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1cnc(N)cn1
CCOC(=O)c1ncccc1N
CCOC(=O)c1cnc(Nc2nc(Nc3ncc(C(=O)N[Dy])s3)nc(Nc3cccnc3C(=O)OCC)n2)cn1
HSA
1
280,704,256
O=C(O)[C@@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
N#Cc1ccc(N)cc1C(F)(F)F
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(Nc4ccc(C#N)c(C(F)(F)F)c4)nc(N4CCC[C@H]4C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
82,173,200
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1CCN(C(N)=O)C1
NCc1nc2ccccc2s1
NC(=O)N1CCC(CNc2nc(NCc3nc4ccccc4s3)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)C1
sEH
1
270,952,330
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
COc1ncc(N)cn1
COc1ncc(Nc2nc(NCCC3CSC3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(I)cc3)n2)cn1
HSA
1
267,029,614
O=C(O)C[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1csc(N)n1
Br.Br.NCC1CCCN1c1cccnn1
CCOC(=O)c1csc(Nc2nc(NCC3CCCN3c3cccnn3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(Cl)c(Cl)c3)n2)n1
HSA
1
270,453,450
O=C(O)C[C@H](Cc1ccc(I)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
Br.Br.NCC1CCCN1c1cccnn1
COc1ccc(Nc2nc(NCC3CCCN3c3cccnn3)nc(N[C@H](CC(=O)N[Dy])Cc3ccc(I)cc3)n2)cc1OC
BRD4
1
112,075,347
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
Cl.NCc1cc(Br)no1
O=C1CCc2cc(Nc3nc(NCc4cc(Br)no4)nc(N[C@H](C(=O)N[Dy])C4CC4)n3)ccc21
BRD4
1
167,341,891
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
CCc1cc(N)n[nH]1
CCc1cc(Nc2nc(NCc3cnc4n3CCOC4)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)n[nH]1
HSA
1
96,260,980
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)c(Cl)n1
Cc1cc2cc(CN)ccc2[nH]1
Cc1ccc(Nc2nc(NCc3ccc4[nH]c(C)cc4c3)nc(N[C@@H](Cc3ccc(Cl)cc3Cl)C(=O)N[Dy])n2)c(Cl)n1
HSA
1
117,237,733
O=C(N[C@H](CCC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1nnc2ncccn12
CN(C)c1cccnc1CN
CN(C)c1cccnc1CNc1nc(NCc2nnc3ncccn23)nc(N[C@H](CCC2CCCCC2)C(=O)N[Dy])n1
HSA
1
3,469,697
C#CC[C@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1occc1N
Cl.NCC12CC3CC(CC(C3)C1)C2
C#CC[C@H](CC(=O)N[Dy])Nc1nc(NCC23CC4CC(CC(C4)C2)C3)nc(Nc2ccoc2C(=O)OC)n1
sEH
1
20,806,464
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CCOC(=O)c1cnc(SC)nc1N
COc1ccc(N)cc1OC
CCCCC(Nc1nc(Nc2ccc(OC)c(OC)c2)nc(Nc2nc(SC)ncc2C(=O)OCC)n1)C(=O)N[Dy]
BRD4
1
149,785,548
O=C(Nc1c(F)cc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(N)ccc1=O
Nc1ccc2c(c1)CNC2=O
Cn1cc(Nc2nc(Nc3ccc4c(c3)CNC4=O)nc(Nc3c(F)cc(C(=O)N[Dy])cc3F)n2)ccc1=O
BRD4
1
82,423,142
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
N#Cc1ccnc(N)c1
CC1(C)CCOC1CCN
CC1(C)CCOC1CCNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cc(C#N)ccn2)n1
sEH
1
17,565,918
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
CCn1cc2cc(N)ccc2n1
NCc1nc2ccccc2s1
CCn1cc2cc(Nc3nc(NCc4nc5ccccc5s4)nc(NC(CC(C)C)C(=O)N[Dy])n3)ccc2n1
BRD4
1
81,885,659
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)ccc1C
NCC1(CO)CC=CC1
COC(=O)c1cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(CO)CC=CC3)n2)ccc1C
sEH
1
285,345,232
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
Cc1n[nH]c(N)c1C
Cc1n[nH]c(Nc2nc(Nc3cccc4cnccc34)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)c1C
HSA
1
81,756,242
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)c1nnc([C@H]2C[C@H](CN)[C@H](O)C2)[nH]1
CC12CCC(CN)(C1)OC2.Cl
CC(C)c1nnc([C@H]2C[C@H](CNc3nc(NCC4CCC(C(=O)N[Dy])CC4)nc(NCC45CCC(C)(CO4)C5)n3)[C@H](O)C2)[nH]1
sEH
1
83,232,170
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1nc(N)ccc1[N+](=O)[O-]
Nc1n[nH]c2c(Cl)cc([N+](=O)[O-])cc12
Cc1nc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3n[nH]c4c(Cl)cc([N+](=O)[O-])cc34)n2)ccc1[N+](=O)[O-]
sEH
1
161,497,806
O=C(Nc1cc(Br)cnc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
Cl.Cn1cc(N)ccc1=O
COc1ccc(CNc2nc(Nc3ccc(=O)n(C)c3)nc(Nc3cc(Br)cnc3C(=O)N[Dy])n2)c(C)c1OC
BRD4
1
82,271,990
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CC2(C1)CC2(F)F
Nc1cc(C(F)(F)F)cnc1Cl
O=C(N[Dy])C1CCC(CNc2nc(NCC3CC4(C3)CC4(F)F)nc(Nc3cc(C(F)(F)F)cnc3Cl)n2)CC1
sEH
1
167,697,817
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Nc1ccncc1Cl
Cc1ccc(CN)c(Cl)n1
Cc1ccc(CNc2nc(Nc3ccncc3Cl)nc(Nc3cc(C(=O)N[Dy])ccc3Cl)n2)c(Cl)n1
HSA
1
19,285,313
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCCC1CSC1
Cl.NCc1cc(Br)no1
CC(OC(C)(C)C)C(Nc1nc(NCCC2CSC2)nc(NCc2cc(Br)no2)n1)C(=O)N[Dy]
sEH
1
82,553,294
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Br)ccc1CO
N#Cc1ccccc1N
N#Cc1ccccc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2cc(Br)ccc2CO)n1
sEH
1
19,198,716
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Nc1ccc(O)cc1Cl
Cl.Cl.NCc1nc2c(s1)CCC2
CC(OC(C)(C)C)C(Nc1nc(NCc2nc3c(s2)CCC3)nc(Nc2ccc(O)cc2Cl)n1)C(=O)N[Dy]
BRD4
1
113,614,927
O=C(N[C@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
CS(=O)CC(O)CN.Cl
Cc1cc(CN)c(C)[nH]1
Cc1cc(CNc2nc(NCC(O)CS(C)=O)nc(N[C@H](C(=O)N[Dy])C3CCCCC3)n2)c(C)[nH]1
HSA
1
104,906,449
O=C(N[C@@H](Cc1ccco1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CSCc1nnc(CN)[nH]1.Cl
Nc1n[nH]c2ncccc12
CSCc1nnc(CNc2nc(Nc3n[nH]c4ncccc34)nc(N[C@@H](Cc3ccco3)C(=O)N[Dy])n2)[nH]1
HSA
1
81,616,893
O=C(NC1(C(=O)O)CCc2ccccc21)OCC1c2ccccc2-c2ccccc21
Nc1cccc2ocnc12
Nc1cc(Cl)c(O)c(Cl)c1
O=C(N[Dy])C1(Nc2nc(Nc3cc(Cl)c(O)c(Cl)c3)nc(Nc3cccc4ocnc34)n2)CCc2ccccc21
BRD4
1
292,736,675
O=C(O)[C@H]1C[C@H](O)CN1C(=O)OCC1c2ccccc2-c2ccccc21
NCC1CCN(c2ccncc2)CC1
COC(=O)c1nc(N)sc1Br
COC(=O)c1nc(Nc2nc(NCC3CCN(c4ccncc4)CC3)nc(N3C[C@@H](O)C[C@@H]3C(=O)N[Dy])n2)sc1Br
sEH
1
214,416,339
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
COC1CCC(CCN)CC1
COC1CCC(CCNc2nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])nc(Nc3cccc(I)c3C(=O)N[Dy])n2)CC1
BRD4
1
201,748,064
O=C(Nc1ccc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cncc(N)c1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
COC(=O)c1cncc(Nc2nc(NCc3ccc(-c4nnn[nH]4)cc3)nc(Nc3ccc(F)cc3C(=O)N[Dy])n2)c1
sEH
1
292,488,691
O=C(O)[C@H]1C[C@H](O)CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cl.Cl.NCc1ncccc1F
O=C(N[Dy])[C@H]1C[C@H](O)CN1c1nc(NCc2cncc(F)c2)nc(NCc2ncccc2F)n1
HSA
1
191,424,817
O=C(Nc1ccc(C(=O)O)cc1F)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
CCc1cc(N)n[nH]1
CCc1cc(Nc2nc(NCCC3CSC3)nc(Nc3ccc(C(=O)N[Dy])cc3F)n2)n[nH]1
HSA
1
83,490,977
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cn1nccc1CN1C[C@@H](F)C[C@H]1CN
CCc1cc(N)n[nH]1
CCc1cc(Nc2nc(NC[C@@H]3C[C@H](F)CN3Cc3ccnn3C)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)n[nH]1
sEH
1
188,384,147
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
Cl.NCC12CC3CC(CC(C3)C1)C2
O=C(N[Dy])c1ccc(Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(Nc3cccc4cnccc34)n2)cc1
sEH
1
264,145,421
O=C(O)C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Cl.NCCS(=O)(=O)Nc1ccccc1
O=C(C[C@H](Cc1c(F)c(F)c(F)c(F)c1F)Nc1nc(NCCS(=O)(=O)Nc2ccccc2)nc(NCc2ccc(O)c3ncccc23)n1)N[Dy]
sEH
1
203,827,518
O=C(Nc1ccc([N+](=O)[O-])c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Cl.Cn1cc(N)ccc1=O
CCC(CNc1nc(Nc2ccc([N+](=O)[O-])c(C(=O)N[Dy])c2)nc(Nc2ccc(=O)n(C)c2)n1)Oc1ccccc1C
BRD4
1
72,561,595
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCc1cnc2n1CCOC2
Cc1nnc(N)s1
Cc1nnc(Nc2nc(NCc3cnc4n3CCOC4)nc(NC(CC3CCCCC3)C(=O)N[Dy])n2)s1
HSA
1
113,786,042
O=C(N[C@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NC[C@@H]3CCO[C@H]3c3cn[nH]c3)nc(N[C@H](C(=O)N[Dy])C3CCCCC3)n2)c1
sEH
1
146,889,014
O=C(Nc1c(Cl)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
Nc1ncnc2[nH]ncc12
O=C(N[Dy])c1cc(F)cc(Cl)c1Nc1nc(Nc2ccc(Cn3ccnc3)cc2)nc(Nc2ncnc3[nH]ncc23)n1
sEH
1
110,989,002
O=C(N[C@@H]1CC[C@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
CCn1nccc1CN
CCn1nccc1CNc1nc(Nc2ccc3c(c2)CNC3=O)nc(N[C@@H]2CC[C@H](C(=O)N[Dy])C2)n1
BRD4
1
285,357,913
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1[N+](=O)[O-]
Nc1ncnc2[nH]ncc12
O=C(N[Dy])[C@@H]1Cc2ccc(O)cc2CN1c1nc(Nc2cccnc2[N+](=O)[O-])nc(Nc2ncnc3[nH]ncc23)n1
HSA
1
113,167,938
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Nc1nccc(=O)[nH]1
O=C1NCc2cc(Nc3nc(Nc4nccc(=O)[nH]4)nc(N[C@H](C(=O)N[Dy])C4CCCC4)n3)ccc21
BRD4
1
19,334,007
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cccc(N2CCOCC2)c1
NCc1cccc(C(=O)N2CCCC2)c1
CC(OC(C)(C)C)C(Nc1nc(NCc2cccc(C(=O)N3CCCC3)c2)nc(NCc2cccc(N3CCOCC3)c2)n1)C(=O)N[Dy]
BRD4
1
18,901,765
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1cc(O)cc(C)c1N
CS(=O)(=O)c1ccc(N)cc1F
Cc1cc(O)cc(C)c1Nc1nc(Nc2ccc(S(C)(=O)=O)c(F)c2)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n1
HSA
1
53,730,080
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cc1cc(C)c(N)c([N+](=O)[O-])c1
Cl.Cl.NCc1cncc(F)c1
Cc1cc(C)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3c(C(=O)N[Dy])ccc(C)c3C)n2)c([N+](=O)[O-])c1
sEH
1
27,707,530
COC(=O)c1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1
Cl.Cl.NCC=Cc1cccnc1
Nc1ccc2nccnc2c1
COC(=O)c1ccc(C(=O)N[Dy])c(Nc2nc(NCC=Cc3cccnc3)nc(Nc3ccc4nccnc4c3)n2)c1
HSA
1
53,564,291
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
COC(=O)c1cc(N)ccc1F
Cl.Cl.NCc1ccc(O)c2ncccc12
COC(=O)c1cc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3c(C(=O)N[Dy])ccc(C)c3C)n2)ccc1F
sEH
1
82,059,002
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(CN)ccc1Oc1ccc(Cl)cc1Cl.Cl
N#Cc1cccc(N)n1
Cc1cc(CNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cccc(C#N)n3)n2)ccc1Oc1ccc(Cl)cc1Cl
sEH
1
138,831,817
O=C(Nc1c(C(=O)O)ccc2ccccc12)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC=Cc1cccnc1
Nc1cncnc1
O=C(N[Dy])c1ccc2ccccc2c1Nc1nc(NCC=Cc2cccnc2)nc(Nc2cncnc2)n1
HSA
1
31,387,825
COc1cc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)cn1
Nc1ccc(-n2cccc2)cc1
CCOC(=O)c1ncccc1N
CCOC(=O)c1ncccc1Nc1nc(Nc2ccc(-n3cccc3)cc2)nc(Nc2cnc(OC)cc2C(=O)N[Dy])n1
HSA
1
22,812,287
CCOc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(Cl)cc1C(=O)O
Nc1cncc(F)c1
N#Cc1c[nH]nc1N
CCOc1cc(Nc2nc(Nc3cncc(F)c3)nc(Nc3n[nH]cc3C#N)n2)c(Cl)cc1C(=O)N[Dy]
sEH
1
82,516,073
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccc2[nH]ccc2c1
Nc1ncc(-c2ccccc2)s1
O=C(N[Dy])C1CCC(CNc2nc(NCc3ccc4[nH]ccc4c3)nc(Nc3ncc(-c4ccccc4)s3)n2)CC1
sEH
1
192,007,464
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
COc1ccc(N)cc1OC
COc1ccc(Nc2nc(NCc3ccc(OC)c(OC)c3C)nc(Nc3ccc(C(=O)N[Dy])cc3O)n2)cc1OC
BRD4
1
212,095,462
O=C(Nc1cccc(Cl)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
NCC1(CO)CC=CC1
Nc1nccc(=O)[nH]1
O=C(N[Dy])c1c(Cl)cccc1Nc1nc(NCC2(CO)CC=CC2)nc(Nc2nccc(=O)[nH]2)n1
HSA
1
16,829,611
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NC[C@@H]1CCO[C@H]1c1cn[nH]c1
Cl.Cl.NCc1ncc[nH]1
CC(C)(C)OCC(Nc1nc(NCc2ncc[nH]2)nc(NC[C@@H]2CCO[C@H]2c2cn[nH]c2)n1)C(=O)N[Dy]
HSA
1
82,111,178
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cccc(OCCCN)c1C.Cl
C=C1CCC(CN)CC1.Cl
C=C1CCC(CNc2nc(NCCCOc3cccc(C)c3C)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)CC1
sEH
1
82,192,529
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCCn1cnc2ccsc2c1=O
COc1c(N)ncnc1Cl
COc1c(Cl)ncnc1Nc1nc(NCCn2cnc3ccsc3c2=O)nc(NCC2CCC(C(=O)N[Dy])CC2)n1
sEH
1
219,084,105
O=C(Nc1cnc(Cl)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCN(CCCN)S(C)(=O)=O
NCc1cc2c(s1)CCSC2
CCN(CCCNc1nc(NCc2cc3c(s2)CCSC3)nc(Nc2cnc(Cl)cc2C(=O)N[Dy])n1)S(C)(=O)=O
BRD4
1
33,559,467
COc1cc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)cc1OC
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
Cl.Cn1cc(N)ccc1=O
COc1cc(Nc2nc(Nc3ccc(=O)n(C)c3)nc(Nc3cc(N4CCNCC4)ccc3[N+](=O)[O-])n2)c(C(=O)N[Dy])cc1OC
BRD4
1
197,614,549
O=C(Nc1ccc(Cl)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1ccncc1N
Nc1ncnc2[nH]cnc12
Cc1ccncc1Nc1nc(Nc2ccc(Cl)c(C(=O)N[Dy])c2)nc(Nc2ncnc3[nH]cnc23)n1
HSA
1
37,714,223
COc1ccc([C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cl.NCc1nnc2ncccn12
COc1cncc(N)c1
COc1ccc([C@H](Nc2nc(NCc3nnc4ncccn34)nc(Nc3cncc(OC)c3)n2)C(=O)N[Dy])cc1
sEH
1
64,836,380
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cl.NCC12CC3CC(CC(C3)C1)C2
COc1ccccc1-c1nnc(N)s1
COc1ccccc1-c1nnc(Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(N[C@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)s1
sEH
1
217,957,401
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
CC(CN)S(N)(=O)=O.Cl
Nc1ccc2c(c1)CNC2=O
CC(CNc1nc(Nc2ccnc(C(=O)N[Dy])c2)nc(Nc2ccc3c(c2)CNC3=O)n1)S(N)(=O)=O
BRD4
1
192,007,482
O=C(Nc1ccc(C(=O)O)cc1O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
COc1ccc([N+](=O)[O-])c(N)n1
COc1ccc([N+](=O)[O-])c(Nc2nc(NCc3ccc(OC)c(OC)c3C)nc(Nc3ccc(C(=O)N[Dy])cc3O)n2)n1
BRD4
1
258,469,851
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccc(Cl)c1
COc1ccc(N)cc1OC
Cn1ccc(S(=O)(=O)NCCN)c1
COc1ccc(Nc2nc(NCCNS(=O)(=O)c3ccn(C)c3)nc(N[C@H](CC(=O)N[Dy])c3cccc(Cl)c3)n2)cc1OC
BRD4
1
78,975,393
O=C(NC1(C(=O)O)CCCCC1)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(N)ccc1=O
Cc1cscc1CN
Cc1cscc1CNc1nc(Nc2ccc(=O)n(C)c2)nc(NC2(C(=O)N[Dy])CCCCC2)n1
BRD4
1
82,471,349
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCC1CCOC1
Nc1nc2c(s1)CN(C(=O)OCc1ccccc1)CC2
O=C(N[Dy])C1CCC(CNc2nc(NCCC3CCOC3)nc(Nc3nc4c(s3)CN(C(=O)OCc3ccccc3)CC4)n2)CC1
sEH
1
167,185,013
O=C(Nc1cc(C(=O)O)ccc1Cl)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc(O)c2ncccc12
Nc1ncco1
O=C(N[Dy])c1ccc(Cl)c(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3ncco3)n2)c1
sEH
1
83,603,048
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCc1ccc2[nH]ccc2c1
NCc1cnc(-c2ccccc2)s1
O=C(N[Dy])[C@H]1CC[C@H](CNc2nc(NCc3ccc4[nH]ccc4c3)nc(NCc3cnc(-c4ccccc4)s3)n2)CC1
sEH
1
87,144,066
O=C(N[C@@H](C(=O)O)C1CCCCC1)OCC1c2ccccc2-c2ccccc21
Nc1nnc(S)s1
NCc1ccsc1Br
O=C(N[Dy])[C@H](Nc1nc(NCc2ccsc2Br)nc(Nc2nnc(S)s2)n1)C1CCCCC1
BRD4
1
83,683,412
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Br)c(F)n1
COc1ncc(N)cc1C(F)(F)F
COc1ncc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3ccc(Br)c(F)n3)n2)cc1C(F)(F)F
sEH
1
19,016,369
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1ccc(O)c2ncccc12
Cc1cnc(CN)s1
Cc1cnc(CNc2nc(NCc3ccc(O)c4ncccc34)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n2)s1
sEH
1
165,018,020
O=C(Nc1cc(C(=O)O)ccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Nc1ncnc2[nH]ncc12
O=C(N[Dy])c1ccc(C(=O)O)c(Nc2nc(NCc3cncc(F)c3)nc(Nc3ncnc4[nH]ncc34)n2)c1
sEH
1
229,110,330
O=C(Nc1ncc(Br)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CSSCCN.Cl
CCOC(=O)c1c[nH]nc1N
CCOC(=O)c1c[nH]nc1Nc1nc(NCCSSC)nc(Nc2ncc(Br)cc2C(=O)N[Dy])n1
BRD4
1
7,893,240
C=CCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(N)cc1OC
Cc1sc(N)c(C#N)c1C
C=CCC[C@@H](Nc1nc(Nc2ccc(OC)c(OC)c2)nc(Nc2sc(C)c(C)c2C#N)n1)C(=O)N[Dy]
BRD4
1
54,518,523
Cc1ccc(C(=O)O)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
CC(C)CC(C)(CN)NC(=O)c1cc(Cl)c(Cl)[nH]1.Cl
NCc1ccc(CN2CCCC2=O)cc1
Cc1ccc(C(=O)N[Dy])cc1Nc1nc(NCc2ccc(CN3CCCC3=O)cc2)nc(NCC(C)(CC(C)C)NC(=O)c2cc(Cl)c(Cl)[nH]2)n1
BRD4
1
18,106,974
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCc1noc2ccc(F)cc12
Cl.NC1CCC(=O)CC1
CC(C)CC(Nc1nc(NCc2noc3ccc(F)cc23)nc(NC2CCC(=O)CC2)n1)C(=O)N[Dy]
BRD4
1
17,981,232
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.NCC1(F)CCCCC1
COc1ccc(N)cc1OC
COc1ccc(Nc2nc(NCC3(F)CCCCC3)nc(NC(CC(C)C)C(=O)N[Dy])n2)cc1OC
BRD4
1
82,169,951
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCC1(N2CCOCC2)CCOCC1
Cc1cc(N)cc(Cl)c1
Cc1cc(Cl)cc(Nc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(NCC3(N4CCOCC4)CCOCC3)n2)c1
sEH
1