id
int64
553
295M
buildingblock1_smiles
stringclasses
271 values
buildingblock2_smiles
stringclasses
693 values
buildingblock3_smiles
stringclasses
866 values
molecule_smiles
stringlengths
44
121
protein_name
stringclasses
3 values
binds
int64
0
1
164,477,991
O=C(Nc1cc(C(=O)O)ccc1Br)OCC1c2ccccc2-c2ccccc21
Nc1ncc(F)cn1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(Nc3ncc(F)cn3)nc(Nc3cc(C(=O)N[Dy])ccc3Br)n2)ccc1=O
BRD4
1
237,018,504
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
Cl.NCCC[C@@H]1NC(=O)NC1=O
CC(=O)SCCN.Cl
CC(=O)SCCNc1nc(NCCC[C@@H]2NC(=O)NC2=O)nc(NC(CC(=O)N[Dy])c2ccc(Br)cc2)n1
BRD4
1
69,147,047
N#Cc1ccc([C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.Cl.NCc1cncc(F)c1
CCOC(=O)c1cc(N)[nH]n1
CCOC(=O)c1cc(Nc2nc(NCc3cncc(F)c3)nc(N[C@@H](CC(=O)N[Dy])c3ccc(C#N)cc3)n2)[nH]n1
sEH
1
213,476,675
O=C(Nc1cccc(F)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cncnc1
N#Cc1c[nH]nc1N
N#Cc1c[nH]nc1Nc1nc(Nc2cncnc2)nc(Nc2cccc(F)c2C(=O)N[Dy])n1
sEH
1
82,111,214
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cccc(OCCCN)c1C.Cl
CC(C)(C)c1ccc(O)c(N)c1
Cc1cccc(OCCCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(C(C)(C)C)ccc3O)n2)c1C
sEH
1
83,879,966
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1noc2ccc(F)cc12
Cc1c(N)cccc1Br
Cc1c(Br)cccc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2noc3ccc(F)cc23)n1
sEH
1
83,648,627
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)c([N+](=O)[O-])cn1
Cl.NCCCNC(=O)C1CCC1
O=C(NCCCNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2cc(Cl)c([N+](=O)[O-])cn2)n1)C1CCC1
sEH
1
81,748,496
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)(CN)C(=O)N1CCCC1
Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1
CC(C)(CNc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)n1)C(=O)N1CCCC1
sEH
1
83,054,849
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
Nc1nc(=O)[nH]cc1Br
COc1ccc(CNc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3nc(=O)[nH]cc3Br)n2)c(C)c1OC
sEH
1
187,996,552
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
Cl.NCCN1C(=O)SC(=Cc2cccs2)C1=O
NCC1CS(=O)(=O)c2ccccc21
O=C(N[Dy])c1ccc(Nc2nc(NCCN3C(=O)SC(=Cc4cccs4)C3=O)nc(NCC3CS(=O)(=O)c4ccccc43)n2)cc1
HSA
1
109,530,171
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.NCCC1CCCC1(F)F
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCCC3CCCC3(F)F)nc(N[C@@H](Cc3cscn3)C(=O)N[Dy])n2)ccc1=O
BRD4
1
94,778,434
O=C(N[C@@H](Cc1ccc(Cl)c(Cl)c1)C(=O)O)OCC1c2ccccc2-c2ccccc21
C#CCOc1cccc(CN)c1.Cl
COC(=O)c1cc(Cl)nc(Cl)c1N
C#CCOc1cccc(CNc2nc(Nc3c(C(=O)OC)cc(Cl)nc3Cl)nc(N[C@@H](Cc3ccc(Cl)c(Cl)c3)C(=O)N[Dy])n2)c1
HSA
1
254,611,985
O=C(O)C[C@@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
NCCC1CSC1
Nc1ccc(F)c(C(F)(F)F)c1
O=C(C[C@@H](Cc1cccs1)Nc1nc(NCCC2CSC2)nc(Nc2ccc(F)c(C(F)(F)F)c2)n1)N[Dy]
sEH
1
81,907,751
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1nccnc1N
Nc1nccc(-c2cccnc2)n1
COC(=O)c1nccnc1Nc1nc(NCC2CCC(C(=O)N[Dy])CC2)nc(Nc2nccc(-c3cccnc3)n2)n1
sEH
1
71,641,819
O=C(CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)OC1CCCCC1
NCc1cccnc1
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(NCc3cccnc3)nc(N[C@@H](CCC(=O)OC3CCCCC3)C(=O)N[Dy])n2)c1
HSA
1
106,630,371
O=C(N[C@@H](Cc1cccs1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Cc1cnc(F)c(CN)c1
Cc1cnc(F)c(CNc2nc(Nc3ccc4c(c3)CNC4=O)nc(N[C@@H](Cc3cccs3)C(=O)N[Dy])n2)c1
BRD4
1
241,793,965
O=C(O)COC[C@H]1CCCN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1cncc(Cl)n1
NCc1cnns1
O=C(COC[C@H]1CCCN1c1nc(NCc2cnns2)nc(Nc2cncc(Cl)n2)n1)N[Dy]
HSA
1
218,295,615
O=C(Nc1ccnc(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(O)c(CN)n1.Cl.Cl
Nc1cc(F)c(F)cc1Br
Cc1ccc(O)c(CNc2nc(Nc3ccnc(C(=O)N[Dy])c3)nc(Nc3cc(F)c(F)cc3Br)n2)n1
BRD4
1
83,794,403
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cccnc1Cl
CS(=O)(=O)c1ccc(N)cc1
CS(=O)(=O)c1ccc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3cccnc3Cl)n2)cc1
sEH
1
122,281,539
O=C(N[C@H](Cc1ccc(Cl)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
Cl.NCCC(=O)NCc1ccccc1
COc1ccc(Nc2nc(NCCC(=O)NCc3ccccc3)nc(N[C@H](Cc3ccc(Cl)cc3)C(=O)N[Dy])n2)cc1OC
BRD4
1
75,008,347
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCC=C(N3CCOCC3)C2=O)cc1
Nc1nc2cc(Br)ccn2n1
O=C(N[Dy])C(Cc1ccccc1)Nc1nc(Nc2ccc(N3CCC=C(N4CCOCC4)C3=O)cc2)nc(Nc2nc3cc(Br)ccn3n2)n1
HSA
1
128,819,337
O=C(N[C@H]1C=C[C@@H](C(=O)O)C1)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
COC1CCC(CCN)CC1
COc1ccc(Nc2nc(NCCC3CCC(OC)CC3)nc(N[C@H]3C=C[C@@H](C(=O)N[Dy])C3)n2)cc1OC
BRD4
1
273,324,258
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
CCC1=NN(Cc2ccccc2C)C(=O)C1CCN
CCC1=NN(Cc2ccccc2C)C(=O)C1CCNc1nc(Nc2ccc3c(c2)CNC3=O)nc(N[C@H](CC(=O)N[Dy])Cc2cccs2)n1
BRD4
1
82,571,561
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cc(Cl)nnc1Cl
Nc1cccc(F)n1
O=C(N[Dy])C1CCC(CNc2nc(Nc3cccc(F)n3)nc(Nc3cc(Cl)nnc3Cl)n2)CC1
sEH
1
82,893,002
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCN(CCCN)S(C)(=O)=O
NCC1(C2CC2)CCCO1
CCN(CCCNc1nc(NCC2(C3CC3)CCCO2)nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)n1)S(C)(=O)=O
sEH
1
82,478,369
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
NCCC1SCCS1
Nc1nc2ccc(Cl)cc2o1
O=C(N[Dy])C1CCC(CNc2nc(NCCC3SCCS3)nc(Nc3nc4ccc(Cl)cc4o3)n2)CC1
sEH
1
251,902,217
O=C(O)C[C@@H](Cc1cccc(F)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
COc1c(N)cccc1F
Cl.NC[C@@H]1C[C@@H]2O[C@H]1[C@H]1C[C@H]12
COc1c(F)cccc1Nc1nc(NC[C@@H]2C[C@@H]3O[C@H]2[C@H]2C[C@H]23)nc(N[C@@H](CC(=O)N[Dy])Cc2cccc(F)c2)n1
sEH
1
54,039,463
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cl.NCc1cnc2n1CCOC2
Cl.Cl.NCC1CCNC(=O)C1
Cc1ccc(C(=O)N[Dy])c(Nc2nc(NCc3cnc4n3CCOC4)nc(NCC3CCNC(=O)C3)n2)c1C
HSA
1
13,341,333
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(N)cc1[N+](=O)[O-]
CSc1nnc(CN)s1
COc1ccc(Nc2nc(NCc3nnc(SC)s3)nc(NC(CCC(=O)OC(C)(C)C)C(=O)N[Dy])n2)cc1[N+](=O)[O-]
BRD4
1
65,100,495
N#Cc1ccc(C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
NCc1ccccc1N1CCOCC1
Cl.Cn1cc(N)ccc1=O
Cn1cc(Nc2nc(NCc3ccccc3N3CCOCC3)nc(N[C@H](Cc3ccc(C#N)cc3)C(=O)N[Dy])n2)ccc1=O
BRD4
1
107,755,759
O=C(N[C@@H](Cc1ccsc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
NCc1cc2c(s1)CCSC2
O=C(N[Dy])[C@H](Cc1ccsc1)Nc1nc(NCc2cc3c(s2)CCSC3)nc(Nc2cccc3cnccc23)n1
HSA
1
83,148,851
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(Cl)nnc1N
Nc1nc2ccc(Cl)cc2o1
Cc1cc(Cl)nnc1Nc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2nc3ccc(Cl)cc3o2)n1
sEH
1
11,087,483
CC(=O)c1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
COC(=O)c1cncc(N)c1
Cl.NCc1ccc(-c2nnn[nH]2)cc1
COC(=O)c1cncc(Nc2nc(NCc3ccc(-c4nnn[nH]4)cc3)nc(N[C@@H](Cc3ccc(C(C)=O)cc3)C(=O)N[Dy])n2)c1
sEH
1
20,972,851
CCCCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(O)c(N)c1
Nc1cc(=O)[nH]c(=O)[nH]1
CCCCC(Nc1nc(Nc2cc(=O)[nH]c(=O)[nH]2)nc(Nc2cc(OC)ccc2O)n1)C(=O)N[Dy]
HSA
1
82,637,345
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(N2CCOCC2)cn1
NCC(c1cccs1)N1CCOCC1
O=C(N[Dy])C1CCC(CNc2nc(NCC(c3cccs3)N3CCOCC3)nc(Nc3ccc(N4CCOCC4)cn3)n2)CC1
sEH
1
231,082,178
O=C(Nc1ncc(C(=O)O)s1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1ccc(F)c(Cl)c1
CCOC(=O)c1ncccc1Nc1nc(Nc2ccc(F)c(Cl)c2)nc(Nc2ncc(C(=O)N[Dy])s2)n1
sEH
1
284,791,173
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Cc1ncc(N)cc1Br
Nc1ccc2c(c1)CNC2=O
Cc1ncc(Nc2nc(Nc3ccc4c(c3)CNC4=O)nc(N3Cc4cc(O)ccc4C[C@H]3C(=O)N[Dy])n2)cc1Br
BRD4
1
108,728,181
O=C(N[C@@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
COC(=O)c1c[nH]c(C(=O)OC)c1N
COC(=O)c1c[nH]c(C(=O)OC)c1Nc1nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])nc(N[C@@H](Cc2csc3ccccc23)C(=O)N[Dy])n1
BRD4
1
17,159,360
CC(C)(C)OCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1ccccc1CS(=O)(=O)N1CCOCC1
Cc1cc(CN)ccc1Oc1ccc(Cl)cc1Cl.Cl
Cc1cc(CNc2nc(NCc3ccccc3CS(=O)(=O)N3CCOCC3)nc(NC(COC(C)(C)C)C(=O)N[Dy])n2)ccc1Oc1ccc(Cl)cc1Cl
sEH
1
285,307,989
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCC2=O
NCc1ccc(F)nc1
O=C1CCc2cc(Nc3nc(NCc4ccc(F)nc4)nc(N4Cc5cc(O)ccc5C[C@H]4C(=O)N[Dy])n3)ccc21
BRD4
1
72,228,887
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
CSSCCN.Cl
CSSCCN.Cl
CSSCCNc1nc(NCCSSC)nc(NC(CC2CCCCC2)C(=O)N[Dy])n1
sEH
1
220,584,607
O=C(Nc1cncc(C(=O)O)n1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
Cl.NC[C@@H]1CCO[C@@H]1c1nc(C2CC2)no1
O=C(N[Dy])c1cncc(Nc2nc(NCc3cncc(F)c3)nc(NC[C@@H]3CCO[C@@H]3c3nc(C4CC4)no3)n2)n1
HSA
1
96,399,990
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(N)ccc1=O
Cc1nc(CCN)sc1C
Cc1nc(CCNc2nc(Nc3ccc(=O)n(C)c3)nc(N[C@@H](Cc3ccc(Cl)cc3Cl)C(=O)N[Dy])n2)sc1C
BRD4
1
226,660,089
O=C(Nc1nc2ccc(C(=O)O)cc2s1)OCC1c2ccccc2-c2ccccc21
CC(CCN)S(C)=O
CC1(C)CC(CN)C(C)(C)O1
CC(CCNc1nc(NCC2CC(C)(C)OC2(C)C)nc(Nc2nc3ccc(C(=O)N[Dy])cc3s2)n1)S(C)=O
BRD4
1
146,887,015
O=C(Nc1c(Cl)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc(Cn2ccnc2)cc1
COC(=O)c1cncc(N)c1
COC(=O)c1cncc(Nc2nc(Nc3ccc(Cn4ccnc4)cc3)nc(Nc3c(Cl)cc(F)cc3C(=O)N[Dy])n2)c1
HSA
1
206,819,872
O=C(Nc1ccc2cc(C(=O)O)ccc2c1)OCC1c2ccccc2-c2ccccc21
Nc1ccc(F)c(Cl)c1F
Cl.NCc1nnc2ncccn12
O=C(N[Dy])c1ccc2cc(Nc3nc(NCc4nnc5ncccn45)nc(Nc4ccc(F)c(Cl)c4F)n3)ccc2c1
HSA
1
72,340,182
O=C(NC(CC1CCCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1nc(Cl)ccc1N
NCC1CS(=O)(=O)c2ccccc21
Cc1nc(Cl)ccc1Nc1nc(NCC2CS(=O)(=O)c3ccccc32)nc(NC(CC2CCCCC2)C(=O)N[Dy])n1
BRD4
1
18,109,158
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Nc1ccc(O)cc1Cl
Cc1cc(N)cc(Cl)c1
Cc1cc(Cl)cc(Nc2nc(Nc3ccc(O)cc3Cl)nc(NC(CC(C)C)C(=O)N[Dy])n2)c1
BRD4
1
25,885,663
CN(C(=O)OCC1c2ccccc2-c2ccccc21)[C@@H](CC1CCCCC1)C(=O)O
NCc1cccs1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCc4cccs4)nc(N(C)[C@@H](CC4CCCCC4)C(=O)N[Dy])n3)ccc2[nH]1
HSA
1
237,181,721
O=C(O)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)c1ccc(Br)cc1
NCCC1CSC1
Cl.NC[C@H]1CC[C@H](C(N)=O)CC1
NC(=O)[C@H]1CC[C@H](CNc2nc(NCCC3CSC3)nc(NC(CC(=O)N[Dy])c3ccc(Br)cc3)n2)CC1
sEH
1
82,148,732
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1nccn1-c1ncccc1CN
Cc1ccc([N+](=O)[O-])c(N)n1
Cc1ccc([N+](=O)[O-])c(Nc2nc(NCc3cccnc3-n3ccnc3C)nc(NCC3CCC(C(=O)N[Dy])CC3)n2)n1
sEH
1
74,584,647
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1ccc[n+]([O-])c1
CCOc1cc(N)ccn1
CCOc1cc(Nc2nc(NCc3ccc[n+]([O-])c3)nc(NC(Cc3ccccc3)C(=O)N[Dy])n2)ccn1
BRD4
1
116,433,669
O=C(N[C@H](CC1CCCC1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CNC2=O
Nc1cc[nH]n1
O=C1NCc2cc(Nc3nc(Nc4cc[nH]n4)nc(N[C@H](CC4CCCC4)C(=O)N[Dy])n3)ccc21
BRD4
1
221,331,129
O=C(Nc1cnccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CNC(=O)COCCN.Cl
NCc1cc(C(F)F)on1
CNC(=O)COCCNc1nc(NCc2cc(C(F)F)on2)nc(Nc2cnccc2C(=O)N[Dy])n1
BRD4
1
111,492,898
O=C(N[C@H](C(=O)O)C1CC1)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)n(C(C)C)n1
Nc1ncnc(=O)[nH]1
Cc1cc(Nc2nc(Nc3ncnc(=O)[nH]3)nc(N[C@H](C(=O)N[Dy])C3CC3)n2)n(C(C)C)n1
HSA
1
187,672,602
O=C(Nc1ccc(C(=O)O)cc1)OCC1c2ccccc2-c2ccccc21
COc1cccc(N)c1F
Cn1nccc1[C@@H]1OCC[C@H]1CN
COc1cccc(Nc2nc(NC[C@@H]3CCO[C@H]3c3ccnn3C)nc(Nc3ccc(C(=O)N[Dy])cc3)n2)c1F
BRD4
1
28,347,048
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
CC(=O)c1ccc(N)c(F)c1
CC(=O)c1ccc(N)c(F)c1
COc1c(F)ccc(C(=O)N[Dy])c1Nc1nc(Nc2ccc(C(C)=O)cc2F)nc(Nc2ccc(C(C)=O)cc2F)n1
BRD4
1
53,948,806
Cc1ccc(C(=O)O)c(NC(=O)OCC2c3ccccc3-c3ccccc32)c1C
Cl.NCC1CC2(C1)CC2(F)F
NCc1cc(C(F)F)on1
Cc1ccc(C(=O)N[Dy])c(Nc2nc(NCc3cc(C(F)F)on3)nc(NCC3CC4(C3)CC4(F)F)n2)c1C
HSA
1
19,528,281
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1ccnc(Cl)n1
Cl.Cn1cc(N)ccc1=O
CC(OC(C)(C)C)C(Nc1nc(Nc2ccc(=O)n(C)c2)nc(Nc2ccnc(Cl)n2)n1)C(=O)N[Dy]
BRD4
1
245,319,616
O=C(O)C[C@@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cnc(N)cn1
Cl.Cl.NCc1cncc(F)c1
COC(=O)c1cnc(Nc2nc(NCc3cncc(F)c3)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(Cl)c(Cl)c3)n2)cn1
HSA
1
510,229
C#CC[C@@H](CC(=O)O)NC(=O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cncc(F)c1
COc1ccc2nc(N)sc2c1
C#CC[C@@H](CC(=O)N[Dy])Nc1nc(NCc2cncc(F)c2)nc(Nc2nc3ccc(OC)cc3s2)n1
HSA
1
66,968,443
N#Cc1ccc(C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)cc1
Cl.Cl.NCc1cncc(F)c1
Cl.NCc1cc(Br)no1
N#Cc1ccc(C[C@H](Nc2nc(NCc3cncc(F)c3)nc(NCc3cc(Br)no3)n2)C(=O)N[Dy])cc1
HSA
1
279,077,591
O=C(O)[C@@H]1CCCCN1C(=O)OCC1c2ccccc2-c2ccccc21
COC(=O)c1cc(N)cc(F)c1
CC(CN)Sc1ccccc1
COC(=O)c1cc(F)cc(Nc2nc(NCC(C)Sc3ccccc3)nc(N3CCCC[C@H]3C(=O)N[Dy])n2)c1
sEH
1
18,787,335
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
COc1ccc(N)cc1OC
NCC1CCCn2ccnc21
COc1ccc(Nc2nc(NCC3CCCn4ccnc43)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n2)cc1OC
BRD4
1
17,864,175
CC(C)CC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cc1nc(Cl)ccc1N
NCC1CCC(F)(F)CC1
Cc1nc(Cl)ccc1Nc1nc(NCC2CCC(F)(F)CC2)nc(NC(CC(C)C)C(=O)N[Dy])n1
BRD4
1
82,723,658
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Nc1cnc(Br)cn1
Cl.NCc1ccsc1C(F)(F)F
O=C(N[Dy])C1CCC(CNc2nc(NCc3ccsc3C(F)(F)F)nc(Nc3cnc(Br)cn3)n2)CC1
sEH
1
83,127,839
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1c(CN)oc2ccc(F)cc12.Cl
Cl.NCC1CC2CC1C1CC21
Cc1c(CNc2nc(NCC3CC4CC3C3CC43)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)oc2ccc(F)cc12
sEH
1
74,343,006
O=C(NC(Cc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(CN)c(C)c1OC
COc1cc(C#N)c(F)cc1N
COc1cc(C#N)c(F)cc1Nc1nc(NCc2ccc(OC)c(OC)c2C)nc(NC(Cc2ccccc2)C(=O)N[Dy])n1
BRD4
1
58,251,829
Cc1ccc(NC(=O)OCC2c3ccccc3-c3ccccc32)c(C(=O)O)c1
Cl.Cl.NCc1cncc(F)c1
Nc1ccc2nccn2c1
Cc1ccc(Nc2nc(NCc3cncc(F)c3)nc(Nc3ccc4nccn4c3)n2)c(C(=O)N[Dy])c1
HSA
1
195,132,824
O=C(Nc1ccc(C(=O)O)nc1)OCC1c2ccccc2-c2ccccc21
CCOC(=O)c1ncccc1N
Nc1nc2c(Br)cccc2s1
CCOC(=O)c1ncccc1Nc1nc(Nc2ccc(C(=O)N[Dy])nc2)nc(Nc2nc3c(Br)cccc3s2)n1
sEH
1
29,715,559
COc1cc(C(=O)O)c(N)cc1NC(=O)OCC1c2ccccc2-c2ccccc21
COc1ncc(N)cn1
Cl.Cl.NCc1ccc(O)c2ncccc12
COc1ncc(Nc2nc(NCc3ccc(O)c4ncccc34)nc(Nc3cc(N)c(C(=O)N[Dy])cc3OC)n2)cn1
HSA
1
65,926,532
N#Cc1ccc(C[C@H](CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Cl.NCC12CC3CC(CC(C3)C1)C2
N#CC1=C(N)CCC1
N#CC1=C(Nc2nc(NCC34CC5CC(CC(C5)C3)C4)nc(N[C@@H](CC(=O)N[Dy])Cc3ccc(C#N)cc3)n2)CCC1
sEH
1
82,982,513
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
COC(=O)c1ccc(N)cc1OC
Cc1nc(Cl)ccc1N
COC(=O)c1ccc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3ccc(Cl)nc3C)n2)cc1OC
sEH
1
216,082,620
O=C(Nc1ccccc1C(=O)c1ccccc1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)ccc1F
Cn1cc(C(F)F)c(CN)n1
Cc1cc(Nc2nc(NCc3nn(C)cc3C(F)F)nc(Nc3ccccc3C(=O)c3ccccc3C(=O)N[Dy])n2)ccc1F
BRD4
1
214,041,823
O=C(Nc1cccc(I)c1C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cccc(-n2ccnn2)c1
COc1cncc(N)n1
COc1cncc(Nc2nc(NCc3cccc(-n4ccnn4)c3)nc(Nc3cccc(I)c3C(=O)N[Dy])n2)n1
HSA
1
28,451,761
COc1c(F)ccc(C(=O)O)c1NC(=O)OCC1c2ccccc2-c2ccccc21
CCOc1ccnc(N)c1
N#Cc1c[nH]nc1N
CCOc1ccnc(Nc2nc(Nc3n[nH]cc3C#N)nc(Nc3c(C(=O)N[Dy])ccc(F)c3OC)n2)c1
HSA
1
285,107,820
O=C(O)[C@@H]1Cc2ccc(O)cc2CN1C(=O)OCC1c2ccccc2-c2ccccc21
NCC1CCCCC(F)(F)C1
CC(CCN)S(C)=O
CC(CCNc1nc(NCC2CCCCC(F)(F)C2)nc(N2Cc3cc(O)ccc3C[C@H]2C(=O)N[Dy])n1)S(C)=O
BRD4
1
82,275,998
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.NCC1CCCC1
Cc1cc2cc(CN)ccc2[nH]1
Cc1cc2cc(CNc3nc(NCC4CCCC4)nc(NCC4CCC(C(=O)N[Dy])CC4)n3)ccc2[nH]1
sEH
1
73,987,651
O=C(NC(CCc1ccccc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1cccc2cnccc12
CC1CN(S(=O)(=O)CCN)CC(C)O1
CC1CN(S(=O)(=O)CCNc2nc(Nc3cccc4cnccc34)nc(NC(CCc3ccccc3)C(=O)N[Dy])n2)CC(C)O1
HSA
1
82,840,463
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)Cn1cnc2c(N)nc3ccccc3c21
C=C(C)COCCN.Cl
C=C(C)COCCNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2nc3ccccc3c3c2ncn3CC(C)C)n1
sEH
1
81,752,363
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CC(C)CC(C)(CN)NC(=O)c1cc(Cl)c(Cl)[nH]1.Cl
CC1(C)NC(=O)N(CCCN)C1=O.Cl
CC(C)CC(C)(CNc1nc(NCCCN2C(=O)NC(C)(C)C2=O)nc(NCC2CCC(C(=O)N[Dy])CC2)n1)NC(=O)c1cc(Cl)c(Cl)[nH]1
sEH
1
13,808,619
CC(C)(C)OC(=O)CCC(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCC1(CO)CCOC1
Nc1ccc2c(c1)CNC2=O
CC(C)(C)OC(=O)CCC(Nc1nc(NCC2(CO)CCOC2)nc(Nc2ccc3c(c2)CNC3=O)n1)C(=O)N[Dy]
BRD4
1
112,631,922
O=C(N[C@H](C(=O)O)C1CCCC1)OCC1c2ccccc2-c2ccccc21
Cc1cnc(Cl)cc1N
COc1ccc2nc(N)sc2c1
COc1ccc2nc(Nc3nc(Nc4cc(Cl)ncc4C)nc(N[C@H](C(=O)N[Dy])C4CCCC4)n3)sc2c1
BRD4
1
146,079,393
O=C(Nc1c(Cl)cc(F)cc1C(=O)O)OCC1c2ccccc2-c2ccccc21
CCC(CN)Oc1ccccc1C.Cl
Nc1ccc2c(c1)CNC2=O
CCC(CNc1nc(Nc2ccc3c(c2)CNC3=O)nc(Nc2c(Cl)cc(F)cc2C(=O)N[Dy])n1)Oc1ccccc1C
BRD4
1
127,730,718
O=C(N[C@H](Cc1csc2ccccc12)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ccc(N)cc1OC
Cn1cc(-c2ccccc2CN)cn1
COc1ccc(Nc2nc(NCc3ccccc3-c3cnn(C)c3)nc(N[C@H](Cc3csc4ccccc34)C(=O)N[Dy])n2)cc1OC
BRD4
1
98,578,546
O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Cl.Cn1cc(CN)c(Br)n1
COc1ccc2nc(N)sc2c1
COc1ccc2nc(Nc3nc(NCc4cn(C)nc4Br)nc(N[C@@H](Cc4ccc(F)cc4)C(=O)N[Dy])n3)sc2c1
HSA
1
82,798,721
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
C#Cc1ccc(N)cc1
Cl.NCc1nc2ccccc2o1
C#Cc1ccc(Nc2nc(NCc3nc4ccccc4o3)nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)n2)cc1
sEH
1
260,402,223
O=C(O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)c1cccs1
CC(=O)SCCN.Cl
Cn1cc(CN)cn1
CC(=O)SCCNc1nc(NCc2cnn(C)c2)nc(N[C@H](CC(=O)N[Dy])c2cccs2)n1
BRD4
1
82,928,582
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
CCSCCN.Cl
Cc1cnc(Cl)nc1N
CCSCCNc1nc(NC[C@H]2CC[C@H](C(=O)N[Dy])CC2)nc(Nc2nc(Cl)ncc2C)n1
sEH
1
96,171,199
O=C(N[C@@H](Cc1ccc(Cl)cc1Cl)C(=O)O)OCC1c2ccccc2-c2ccccc21
COc1ncccc1N
Cc1cc2cc(CN)ccc2[nH]1
COc1ncccc1Nc1nc(NCc2ccc3[nH]c(C)cc3c2)nc(N[C@@H](Cc2ccc(Cl)cc2Cl)C(=O)N[Dy])n1
HSA
1
272,745,506
O=C(O)C[C@H](Cc1cccs1)NC(=O)OCC1c2ccccc2-c2ccccc21
Cc1cc(N)on1
CC(C)(CN)CCC#N
Cc1cc(Nc2nc(NCC(C)(C)CCC#N)nc(N[C@H](CC(=O)N[Dy])Cc3cccs3)n2)on1
sEH
1
83,187,632
O=C(NC[C@H]1CC[C@H](C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1ccc(N)c(Cl)n1
CS(=O)(=O)Nc1ccc(-c2csc(N)n2)cc1
Cc1ccc(Nc2nc(NC[C@H]3CC[C@H](C(=O)N[Dy])CC3)nc(Nc3nc(-c4ccc(NS(C)(=O)=O)cc4)cs3)n2)c(Cl)n1
sEH
1
19,376,401
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Nc1cc(Cl)ccc1F
Nc1nnn[nH]1
CC(OC(C)(C)C)C(Nc1nc(Nc2nnn[nH]2)nc(Nc2cc(Cl)ccc2F)n1)C(=O)N[Dy]
HSA
1
109,898,379
O=C(N[C@@H](Cc1cscn1)C(=O)O)OCC1c2ccccc2-c2ccccc21
Nc1ccc2c(c1)CCCC2=O
NCc1noc2c1COCC2
O=C1CCCc2cc(Nc3nc(NCc4noc5c4COCC5)nc(N[C@@H](Cc4cscn4)C(=O)N[Dy])n3)ccc21
BRD4
1
19,037,148
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
Cl.Cl.NCc1ncc[nH]1
COC(=O)c1ccc(N)cc1C
COC(=O)c1ccc(Nc2nc(NCc3ncc[nH]3)nc(NC(C(=O)N[Dy])C(C)OC(C)(C)C)n2)cc1C
BRD4
1
82,210,679
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cl.Cl.NCc1cccc(-n2ccnn2)c1
Nc1nccs1
O=C(N[Dy])C1CCC(CNc2nc(NCc3cccc(-n4ccnn4)c3)nc(Nc3nccs3)n2)CC1
sEH
1
19,322,046
CC(OC(C)(C)C)C(NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
NCc1cc(-c2ccccc2)[nH]n1
Nc1cc(N2CCNCC2)ccc1[N+](=O)[O-]
CC(OC(C)(C)C)C(Nc1nc(NCc2cc(-c3ccccc3)[nH]n2)nc(Nc2cc(N3CCNCC3)ccc2[N+](=O)[O-])n1)C(=O)N[Dy]
BRD4
1
182,958,227
O=C(Nc1ccc(C(=O)O)c(C(=O)O)c1)OCC1c2ccccc2-c2ccccc21
Nc1cn[nH]c1
Nc1cncc(F)c1
O=C(O)c1cc(Nc2nc(Nc3cn[nH]c3)nc(Nc3cncc(F)c3)n2)ccc1C(=O)N[Dy]
sEH
1
56,555,635
Cc1ccc(C(CC(=O)O)NC(=O)OCC2c3ccccc3-c3ccccc32)cc1
Nc1cccc2cnccc12
CN1CCN(c2ccc(N)cc2F)CC1
Cc1ccc(C(CC(=O)N[Dy])Nc2nc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc(Nc3cccc4cnccc34)n2)cc1
HSA
1
82,112,225
O=C(NCC1CCC(C(=O)O)CC1)OCC1c2ccccc2-c2ccccc21
Cc1cccc(OCCCN)c1C.Cl
Cn1c(=O)cc(N)[nH]c1=O
Cc1cccc(OCCCNc2nc(NCC3CCC(C(=O)N[Dy])CC3)nc(Nc3cc(=O)n(C)c(=O)[nH]3)n2)c1C
sEH
1