row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:6106 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,106 | train | mutant | 458 | 76 | 507 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57M | F57M | 1 | 1 | 0 | 0 | 57 | F | M | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 751 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:F22M | 84 | null | null | null | 68.4 | null | 68.6 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:F22M","type":"_... | [{"datasets":[],"id":2871,"numValue":84.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":2872,"numValue":68.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":2873,"numValue":68.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":2874,"numValue":null,"references":[],"s... | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6107 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,107 | train | mutant | 458 | 76 | 507 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57M | F57M | 1 | 1 | 0 | 0 | 57 | F | M | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 8,852 | ProTherm | 4.3 | DSC | Thermal | GlyGly/HCl | 10 mM | 25 | 1BPI_A:F22M | null | null | 8.8 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GlyGly/HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER... | [{"datasets":[],"id":29991,"numValue":8.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29992,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6108 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,108 | train | mutant | 873 | 76 | 988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57A | F57A | 1 | 1 | 0 | 0 | 57 | F | A | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 1,506 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:F22A | 78 | -9 | null | null | 68 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":5512,"numValue":78.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":5513,"numValue":-9.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":5514,"numValue":68.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id"... | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6109 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,109 | train | mutant | 873 | 76 | 988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57A | F57A | 1 | 1 | 0 | 0 | 57 | F | A | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 2,960 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:F22A | 24.5 | -14.7 | null | null | 37 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Broom_S605.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S2204.csv"],"id":10736,"numValue":24.5,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":10737,"numValue":-14.7,"references":[],"strValue":null... | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6110 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,110 | train | mutant | 873 | 76 | 988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57A | F57A | 1 | 1 | 0 | 0 | 57 | F | A | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 8,179 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:F22A | null | null | null | 2 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","potapov_with_uniprot_mapping.csv"],"id":27748,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27749,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6111 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,111 | train | mutant | 873 | 76 | 988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57A | F57A | 1 | 1 | 0 | 0 | 57 | F | A | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 9,239 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 N | 1BPI_A:F22A | null | null | 7.8 | 1.2 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":31554,"numValue":7.8,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":31555,"numValue":1.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":31556,"numValue":null,"references":[],"strValue":"Unknown","type":"RE... | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6112 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,112 | train | mutant | 873 | 76 | 988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57A | F57A | 1 | 1 | 0 | 0 | 57 | F | A | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 12,786 | ProTherm | 2 | CD | GdnHCl | glycine | 20 mM | 20 | 1BPI_A:F22A | null | null | 8 | 1 | null | null | null | 8.19 | 0.97 | null | null | null | null | null | null | null | yes (>90%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 822 | ARTICLE | Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding. | 2,002 | 10.1021/bi0116947 | 11841216 | Biochemistry;41;2246-53 | 3 | Li Renhao|Battiste John L|Woodward Clare | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC... | [{"datasets":[],"id":46457,"numValue":8.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46458,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46459,"numValue":0.97,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46460,"numValue":8.19,"references":[],"s... | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6113 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,113 | train | mutant | 4,819 | 76 | 5,360 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F57L | F57L | 1 | 1 | 0 | 0 | 57 | F | L | 6 | CONSERVATION | 1BPI | 57 | null | 57 | A | E | false | false | 24.594619 | 4.535455 | 11,324 | ProTherm | 8.7 | Gel electrophoresis | Urea | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:F22L | null | null | 5.6 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 755 | ARTICLE | Mutational analysis of the BPTI folding pathway: II. Effects of aromatic-->leucine substitutions on folding kinetics and thermodynamics. | 1,997 | 10.1002/pro.5560060720 | 9232657 | Protein Sci;6;1563-76 | 2 | Goldenberg D P|Zhang J X | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Gel electrophoresis","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","ty... | [{"datasets":[],"id":38988,"numValue":5.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38989,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7643,"numValue":6.0,"position":57,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6114 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,114 | train | mutant | 874 | 76 | 989 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y58A | Y58A | 1 | 1 | 0 | 0 | 58 | Y | A | 8 | CONSERVATION | 1BPI | 57 | null | 58 | A | E | false | false | 9.961935 | 5.358333 | 1,507 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:Y23A | 54 | -33 | null | null | 45 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":5516,"numValue":54.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":5517,"numValue":-33.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":5518,"numValue":45.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id... | [{"id":7644,"numValue":8.0,"position":58,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6115 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,115 | train | mutant | 874 | 76 | 989 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y58A | Y58A | 1 | 1 | 0 | 0 | 58 | Y | A | 8 | CONSERVATION | 1BPI | 57 | null | 58 | A | E | false | false | 9.961935 | 5.358333 | 9,240 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 N | 1BPI_A:Y23A | null | null | 3.1 | 5.9 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":31557,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":31558,"numValue":5.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":31559,"numValue":null,"references"... | [{"id":7644,"numValue":8.0,"position":58,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6116 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,116 | train | mutant | 874 | 76 | 989 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y58A | Y58A | 1 | 1 | 0 | 0 | 58 | Y | A | 8 | CONSERVATION | 1BPI | 57 | null | 58 | A | E | false | false | 9.961935 | 5.358333 | 12,787 | ProTherm | 2 | CD | GdnHCl | glycine | 20 mM | 20 | 1BPI_A:Y23A | null | null | 3 | 6 | null | null | null | 3.53 | 0.85 | null | null | null | null | null | null | null | yes (>90%) | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 822 | ARTICLE | Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding. | 2,002 | 10.1021/bi0116947 | 11841216 | Biochemistry;41;2246-53 | 3 | Li Renhao|Battiste John L|Woodward Clare | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC... | [{"datasets":[],"id":46462,"numValue":3.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":46463,"numValue":6.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46464,"numValue":0.85,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46465,"numValue":3.53,... | [{"id":7644,"numValue":8.0,"position":58,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6117 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,117 | train | mutant | 4,820 | 76 | 5,361 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y58L | Y58L | 1 | 1 | 0 | 0 | 58 | Y | L | 8 | CONSERVATION | 1BPI | 57 | null | 58 | A | E | false | false | 9.961935 | 5.358333 | 11,325 | ProTherm | 8.7 | Gel electrophoresis | Urea | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:Y23L | null | null | 7.1 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 755 | ARTICLE | Mutational analysis of the BPTI folding pathway: II. Effects of aromatic-->leucine substitutions on folding kinetics and thermodynamics. | 1,997 | 10.1002/pro.5560060720 | 9232657 | Protein Sci;6;1563-76 | 2 | Goldenberg D P|Zhang J X | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Gel electrophoresis","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","ty... | [{"datasets":[],"id":38990,"numValue":7.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38991,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7644,"numValue":8.0,"position":58,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6118 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,118 | train | mutant | 1,569 | 76 | 1,768 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N59A | N59A | 1 | 1 | 0 | 0 | 59 | N | A | 8 | CONSERVATION | 1BPI | 57 | null | 59 | A | E | false | false | 37.196583 | 5.075 | 2,961 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:N24A | 23.4 | -15.8 | null | null | 40 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Broom_S605.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S2204.csv"],"id":10740,"numValue":23.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10741,"numValue":-15.8,"references":... | [{"id":7645,"numValue":8.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6119 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,119 | train | mutant | 1,569 | 76 | 1,768 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N59A | N59A | 1 | 1 | 0 | 0 | 59 | N | A | 8 | CONSERVATION | 1BPI | 57 | null | 59 | A | E | false | false | 37.196583 | 5.075 | 8,180 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:N24A | null | null | null | 2.2 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27750,"numValue":2.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27751,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7645,"numValue":8.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6121 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,121 | train | mutant | 1,570 | 76 | 1,769 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K61A | K61A | 1 | 1 | 0 | 0 | 61 | K | A | 3 | CONSERVATION | 1BPI | 57 | null | 61 | A | T | false | false | 203.984488 | 6.958889 | 8,181 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:K26A | null | null | null | 0 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27752,"numValue":0.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_map... | [{"id":7647,"numValue":3.0,"position":61,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6122 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,122 | train | mutant | 1,571 | 76 | 1,770 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G63A | G63A | 1 | 1 | 0 | 0 | 63 | G | A | 4 | CONSERVATION | 1BPI | 57 | null | 63 | A | T | false | false | 40.872364 | 5.4125 | 2,963 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:G28A | 31.9 | -7.3 | null | null | 43 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10748,"numValue":31.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10749,"numValue":-7.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":["Saraboji_... | [{"id":7649,"numValue":4.0,"position":63,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6123 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,123 | train | mutant | 1,571 | 76 | 1,770 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G63A | G63A | 1 | 1 | 0 | 0 | 63 | G | A | 4 | CONSERVATION | 1BPI | 57 | null | 63 | A | T | false | false | 40.872364 | 5.4125 | 8,182 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:G28A | null | null | null | 1 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27754,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27755,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7649,"numValue":4.0,"position":63,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6124 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,124 | train | mutant | 459 | 76 | 508 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | L64M | L64M | 1 | 1 | 0 | 0 | 64 | L | M | 3 | CONSERVATION | 1BPI | 57 | null | 64 | A | E | false | false | 103.734369 | 5.8925 | 752 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:L29M | 100.8 | null | null | null | 78.9 | null | 80 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | HotMuSiC_S1626.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:L29M","type":"_... | [{"datasets":["HotMuSiC_S1626.csv"],"id":2875,"numValue":100.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["HotMuSiC_S1626.csv"],"id":2876,"numValue":78.9,"references":[],"strValue":null,"type":"DH"},{"datasets":["HotMuSiC_S1626.csv"],"id":2877,"numValue":80.0,"references":[],"strValue":null,"type":"DHVH"... | [{"id":7650,"numValue":3.0,"position":64,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6125 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,125 | train | mutant | 459 | 76 | 508 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | L64M | L64M | 1 | 1 | 0 | 0 | 64 | L | M | 3 | CONSERVATION | 1BPI | 57 | null | 64 | A | E | false | false | 103.734369 | 5.8925 | 8,853 | ProTherm | 4.3 | DSC | Thermal | GlyGly/HCl | 10 mM | 25 | 1BPI_A:L29M | null | null | 13.3 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GlyGly/HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER... | [{"datasets":[],"id":29993,"numValue":13.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29994,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7650,"numValue":3.0,"position":64,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6126 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,126 | train | mutant | 1,572 | 76 | 1,771 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | L64A | L64A | 1 | 1 | 0 | 0 | 64 | L | A | 3 | CONSERVATION | 1BPI | 57 | null | 64 | A | E | false | false | 103.734369 | 5.8925 | 2,964 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:L29A | 39.5 | 0.3 | null | null | 42 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1962.csv|Broom_S605.csv|PoPMuSiC-2.0_S2648.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10752,"numValue":39.5,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","capriotti_S1615_map.csv","guerios_625_map.cs... | [{"id":7650,"numValue":3.0,"position":64,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6127 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,127 | train | mutant | 1,572 | 76 | 1,771 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | L64A | L64A | 1 | 1 | 0 | 0 | 64 | L | A | 3 | CONSERVATION | 1BPI | 57 | null | 64 | A | E | false | false | 103.734369 | 5.8925 | 8,183 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:L29A | null | null | null | 0 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27756,"numValue":0.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_map... | [{"id":7650,"numValue":3.0,"position":64,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6128 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,128 | train | mutant | 6,843 | 76 | 7,485 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65A|C86A | C65A|C86A | 2 | 2 | 0 | 0 | 65 | C | A | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,672 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30A 1BPI_A:C51A | 71 | -33 | null | null | 59.4 | null | 64.8 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54256,"numValue":71.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54257,"numValue":-33.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54258,"numValue":59.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54259,"numValue":64.8,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6129 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,129 | train | mutant | 6,843 | 76 | 7,485 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65A|C86A | C65A|C86A | 2 | 2 | 0 | 0 | 65 | C | A | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,865 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30A 1BPI_A:C51A | null | null | null | 6.14 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54861,"numValue":6.14,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54862,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6131 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,131 | train | mutant | 6,844 | 76 | 7,486 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65V|C86A | C65V|C86A | 2 | 2 | 0 | 0 | 65 | C | V | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,673 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30V 1BPI_A:C51A | 72 | -32 | null | null | 59.5 | null | 58.9 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54261,"numValue":72.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54262,"numValue":-32.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54263,"numValue":59.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54264,"numValue":58.9,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6132 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,132 | train | mutant | 6,844 | 76 | 7,486 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65V|C86A | C65V|C86A | 2 | 2 | 0 | 0 | 65 | C | V | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,866 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30V 1BPI_A:C51A | null | null | null | 5.95 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54863,"numValue":5.95,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54864,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6134 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,134 | train | mutant | 6,845 | 76 | 7,487 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65G|C86A | C65G|C86A | 2 | 2 | 0 | 0 | 65 | C | G | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,674 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30G 1BPI_A:C51A | 57 | -47 | null | null | 51.9 | null | 54.6 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54266,"numValue":57.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54267,"numValue":-47.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54268,"numValue":51.9,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54269,"numValue":54.6,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6135 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,135 | train | mutant | 6,845 | 76 | 7,487 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65G|C86A | C65G|C86A | 2 | 2 | 0 | 0 | 65 | C | G | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,867 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30G 1BPI_A:C51A | null | null | null | 8.74 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54865,"numValue":8.74,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54866,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6136 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,136 | train | mutant | 6,846 | 76 | 7,488 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65T|C86A | C65T|C86A | 2 | 2 | 0 | 0 | 65 | C | T | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,675 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30T 1BPI_A:C51A | 62 | -42 | null | null | 52.4 | null | 53.9 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54271,"numValue":62.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54272,"numValue":-42.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54273,"numValue":52.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54274,"numValue":53.9,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6137 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,137 | train | mutant | 6,846 | 76 | 7,488 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65T|C86A | C65T|C86A | 2 | 2 | 0 | 0 | 65 | C | T | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,868 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30T 1BPI_A:C51A | null | null | null | 7.81 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54867,"numValue":7.81,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54868,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6138 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,138 | train | mutant | 6,846 | 76 | 7,488 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65T|C86A | C65T|C86A | 2 | 2 | 0 | 0 | 65 | C | T | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 15,303 | ProTherm | 7.8 | Absorbance | GdnHCl | Potassium phosphate | 10 mM | 25 | 1BPI_A:C30T 1BPI_A:C51A | null | null | 4.6 | null | null | null | null | 3.81 | 1.21 | null | null | null | null | null | null | null | yes | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 924 | ARTICLE | Denaturant-dependent folding of bovine pancreatic trypsin inhibitor mutants with two intact disulfide bonds. | 1,990 | 10.1021/bi00470a021 | 1693524 | Biochemistry;29;4410-9 | 5 | Anderson S|Hurle M R|Marks C B|Kosen P A|Kuntz I D | [{"numValue":7.8,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Absorbance","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM"... | [{"datasets":[],"id":56155,"numValue":4.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":56156,"numValue":1.21,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":56157,"numValue":3.81,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":56158,"numValue":null,"references":[],"s... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6139 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,139 | train | mutant | 6,847 | 76 | 7,489 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65S|C86A | C65S|C86A | 2 | 2 | 0 | 0 | 65 | C | S | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,676 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30S 1BPI_A:C51A | 61 | -43 | null | null | 55.7 | null | 56.6 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54276,"numValue":61.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54277,"numValue":-43.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54278,"numValue":55.7,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54279,"numValue":56.6,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6140 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,140 | train | mutant | 6,847 | 76 | 7,489 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65S|C86A | C65S|C86A | 2 | 2 | 0 | 0 | 65 | C | S | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,869 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30S 1BPI_A:C51A | null | null | null | 8 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54869,"numValue":8.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54870,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6141 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,141 | train | mutant | 6,848 | 76 | 7,490 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65A|C86S | C65A|C86S | 2 | 2 | 0 | 0 | 65 | C | A | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,677 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | null | NaCl | 0.1 M | 1BPI_A:C30A 1BPI_A:C51S | 56 | -48 | null | null | 50.4 | null | 57.5 | null | null | null | null | null | null | null | null | null | no | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":... | [{"datasets":[],"id":54281,"numValue":56.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54282,"numValue":-48.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54283,"numValue":50.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54284,"numValue":57.5,"references":[... | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6142 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,142 | train | mutant | 6,848 | 76 | 7,490 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | C65A|C86S | C65A|C86S | 2 | 2 | 0 | 0 | 65 | C | A | 9 | CONSERVATION | 1BPI | 57 | null | 65|86 | A | E|H | false | false | 14.826247 | 4.950833 | 14,870 | ProTherm | 7 | DSC | Thermal | Potassium phosphate | 10 mM | 105 | NaCl | 0.1 M | 1BPI_A:C30A 1BPI_A:C51S | null | null | null | 8.93 | null | null | null | null | null | null | null | null | null | null | null | null | no | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 905 | ARTICLE | "Designing out" disulfide bonds: thermodynamic properties of 30-51 cystine substitution mutants of bovine pancreatic trypsin inhibitor. | 1,997 | 10.1021/bi962423c | 9154914 | Biochemistry;36;5323-35 | 3 | Liu Y|Anderson S|Breslauer K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":105.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","typ... | [{"datasets":[],"id":54871,"numValue":8.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":54872,"numValue":null,"references":[],"strValue":"no","type":"REVERSIBILITY"}] | [{"id":7651,"numValue":9.0,"position":65,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7672,"numValue":9.0,"position":86,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6144 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,144 | train | mutant | 1,573 | 76 | 1,772 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Q66A | Q66A | 1 | 1 | 0 | 0 | 66 | Q | A | 5 | CONSERVATION | 1BPI | 57 | null | 66 | A | E | false | false | 64.748916 | 5.978889 | 8,184 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:Q31A | null | null | null | 1 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27758,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27759,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7652,"numValue":5.0,"position":66,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6145 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,145 | train | mutant | 460 | 76 | 509 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | T67M | T67M | 1 | 1 | 0 | 0 | 67 | T | M | 3 | CONSERVATION | 1BPI | 57 | null | 67 | A | E | false | false | 80.287234 | 4.832857 | 753 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:T32M | 91 | null | null | null | 64.8 | null | 67.5 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | HotMuSiC_S1626.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:T32M","type":"_... | [{"datasets":["HotMuSiC_S1626.csv"],"id":2879,"numValue":91.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["HotMuSiC_S1626.csv"],"id":2880,"numValue":64.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":2881,"numValue":67.5,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id"... | [{"id":7653,"numValue":3.0,"position":67,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6146 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,146 | train | mutant | 460 | 76 | 509 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | T67M | T67M | 1 | 1 | 0 | 0 | 67 | T | M | 3 | CONSERVATION | 1BPI | 57 | null | 67 | A | E | false | false | 80.287234 | 4.832857 | 8,854 | ProTherm | 4.3 | DSC | Thermal | GlyGly/HCl | 10 mM | 25 | 1BPI_A:T32M | null | null | 9.3 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GlyGly/HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER... | [{"datasets":[],"id":29995,"numValue":9.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":29996,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7653,"numValue":3.0,"position":67,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6147 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,147 | train | mutant | 1,574 | 76 | 1,773 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | T67A | T67A | 1 | 1 | 0 | 0 | 67 | T | A | 3 | CONSERVATION | 1BPI | 57 | null | 67 | A | E | false | false | 80.287234 | 4.832857 | 2,966 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:T32A | 38.8 | -0.4 | null | null | 40 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1925.csv|AUTOMUTE_S1962.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1925.csv","AUTOMUTE_S1962.csv","EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S2760.csv","PON-TStab_dataset.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S2204.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],... | [{"id":7653,"numValue":3.0,"position":67,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6148 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,148 | train | mutant | 1,574 | 76 | 1,773 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | T67A | T67A | 1 | 1 | 0 | 0 | 67 | T | A | 3 | CONSERVATION | 1BPI | 57 | null | 67 | A | E | false | false | 80.287234 | 4.832857 | 8,185 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:T32A | null | null | null | 0.1 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27760,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27761,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7653,"numValue":3.0,"position":67,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6149 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,149 | train | mutant | 1,842 | 76 | 2,063 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F68A | F68A | 1 | 1 | 0 | 0 | 68 | F | A | 9 | CONSERVATION | 1BPI | 57 | null | 68 | A | E | false | false | 22.817444 | 4.789091 | 3,555 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:F33A | 77.7 | -16.5 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:F33A","type":"_PDB_... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13084,"numValue":77.7,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13085,"numValue":-16.5,"references":[],"strValue":nu... | [{"id":7654,"numValue":9.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6150 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,150 | train | mutant | 4,464 | 76 | 4,984 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F68I | F68I | 1 | 1 | 0 | 0 | 68 | F | I | 9 | CONSERVATION | 1BPI | 57 | null | 68 | A | E | false | false | 22.817444 | 4.789091 | 10,554 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:F33I | null | null | null | 2.4 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["SAAFEC_S1262.csv"],"id":36291,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36292,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7654,"numValue":9.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6151 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,151 | train | mutant | 4,465 | 76 | 4,985 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F68L | F68L | 1 | 1 | 0 | 0 | 68 | F | L | 9 | CONSERVATION | 1BPI | 57 | null | 68 | A | E | false | false | 22.817444 | 4.789091 | 10,555 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:F33L | null | null | null | 1.3 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["SAAFEC_S1262.csv"],"id":36293,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36294,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7654,"numValue":9.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6152 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,152 | train | mutant | 4,465 | 76 | 4,985 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F68L | F68L | 1 | 1 | 0 | 0 | 68 | F | L | 9 | CONSERVATION | 1BPI | 57 | null | 68 | A | E | false | false | 22.817444 | 4.789091 | 11,326 | ProTherm | 8.7 | Gel electrophoresis | Urea | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:F33L | null | null | 4.1 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 755 | ARTICLE | Mutational analysis of the BPTI folding pathway: II. Effects of aromatic-->leucine substitutions on folding kinetics and thermodynamics. | 1,997 | 10.1002/pro.5560060720 | 9232657 | Protein Sci;6;1563-76 | 2 | Goldenberg D P|Zhang J X | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Gel electrophoresis","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","ty... | [{"datasets":[],"id":38992,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38993,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7654,"numValue":9.0,"position":68,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6153 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,153 | train | mutant | 1,575 | 76 | 1,774 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | V69A | V69A | 1 | 1 | 0 | 0 | 69 | V | A | 4 | CONSERVATION | 1BPI | 57 | null | 69 | A | E | false | false | 61.858894 | 6.002857 | 2,967 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:V34A | 30.2 | -9 | null | null | 41 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|AUTOMUTE_S1925.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":[],"id":10764,"numValue":30.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1925.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S1810.csv","M47andM8_S2760.csv","Saraboji_S1791.csv"],"id":10765,"numValue":-9.0,"references":[... | [{"id":7655,"numValue":4.0,"position":69,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6154 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,154 | train | mutant | 1,575 | 76 | 1,774 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | V69A | V69A | 1 | 1 | 0 | 0 | 69 | V | A | 4 | CONSERVATION | 1BPI | 57 | null | 69 | A | E | false | false | 61.858894 | 6.002857 | 3,566 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:V34A | 94.2 | 0 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:V34A","type":"_PDB_... | [{"datasets":["STRUM_Q3421.csv"],"id":13117,"numValue":94.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":13118,"numValue":0.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":13119,"numValue":null,"references":[],"strValue":"yes","type":"REVE... | [{"id":7655,"numValue":4.0,"position":69,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6155 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,155 | train | mutant | 1,575 | 76 | 1,774 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | V69A | V69A | 1 | 1 | 0 | 0 | 69 | V | A | 4 | CONSERVATION | 1BPI | 57 | null | 69 | A | E | false | false | 61.858894 | 6.002857 | 8,186 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:V34A | null | null | null | 1.2 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27762,"numValue":1.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27763,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7655,"numValue":4.0,"position":69,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6157 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,157 | train | mutant | 875 | 76 | 990 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70G | Y70G | 1 | 1 | 0 | 0 | 70 | Y | G | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 2,984 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:Y35G | 69 | -18 | null | null | 38 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":10831,"numValue":69.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":10832,"numValue":-18.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":10833,"numValue":38.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],... | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6158 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,158 | train | mutant | 875 | 76 | 990 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70G | Y70G | 1 | 1 | 0 | 0 | 70 | Y | G | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 8,762 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 M | 1BPI_A:Y35G | null | null | 4 | 5 | null | 0.7 | null | null | null | null | null | null | null | null | null | null | Unknown | DCP|DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":29599,"numValue":0.7,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29600,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":29601,"numValue... | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6159 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,159 | train | mutant | 875 | 76 | 990 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70G | Y70G | 1 | 1 | 0 | 0 | 70 | Y | G | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 9,241 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 N | 1BPI_A:Y35G | null | null | 4 | 5 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":31560,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":31561,"numValue":5.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":31562,"numValue... | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6160 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,160 | train | mutant | 875 | 76 | 990 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70G | Y70G | 1 | 1 | 0 | 0 | 70 | Y | G | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 10,559 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:Y35G | null | null | null | 5 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":36301,"numValue":5.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36302,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6161 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,161 | train | mutant | 1,576 | 76 | 1,775 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70A | Y70A | 1 | 1 | 0 | 0 | 70 | Y | A | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 2,968 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:Y35A | 30.9 | -8.3 | null | null | 29 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1925.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|SVM-WIN31_SVM-3D12_S499.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|EASE-MM_S1676.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1925.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S1810.csv","M47andM8_S2760.csv","SVM-WIN31_SVM-3D12_S499.csv"],"id":10768,"numValue":30.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1925.csv","I_Mutant2.0_... | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6162 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,162 | train | mutant | 1,576 | 76 | 1,775 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70A | Y70A | 1 | 1 | 0 | 0 | 70 | Y | A | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 3,557 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:Y35A | 78 | -16.2 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:Y35A","type":"_PDB_... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13090,"numValue":78.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13091,"numValue":-16.2,"references":[],"strValue":nu... | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6163 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,163 | train | mutant | 1,576 | 76 | 1,775 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70A | Y70A | 1 | 1 | 0 | 0 | 70 | Y | A | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 8,187 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:Y35A | null | null | null | 1.1 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27764,"numValue":1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27765,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6164 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,164 | train | mutant | 1,576 | 76 | 1,775 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70A | Y70A | 1 | 1 | 0 | 0 | 70 | Y | A | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 10,556 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:Y35A | null | null | null | 4.7 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["SAAFEC_S1262.csv"],"id":36295,"numValue":4.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36296,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6166 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,166 | train | mutant | 4,467 | 76 | 4,987 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70F | Y70F | 1 | 1 | 0 | 0 | 70 | Y | F | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 10,558 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:Y35F | null | null | null | 0.6 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["SAAFEC_S1262.csv"],"id":36299,"numValue":0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36300,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6167 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,167 | train | mutant | 4,468 | 76 | 4,988 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | Y70L | Y70L | 1 | 1 | 0 | 0 | 70 | Y | L | 9 | CONSERVATION | 1BPI | 57 | null | 70 | A | E | false | false | 14.639038 | 5.239167 | 10,560 | ProTherm | 8.7 | HPLC | GSSG, GSH | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:Y35L | null | null | null | 3.7 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 693 | ARTICLE | Probing the determinants of disulfide stability in native pancreatic trypsin inhibitor. | 1,993 | 10.1021/bi00062a015 | 7681323 | Biochemistry;32;2835-44 | 4 | Goldenberg D P|Bekeart L S|Laheru D A|Zhou J D | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"HPLC","type":"MEASURE"},{"numValue":null,"strValue":"GSSG, GSH","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","type":"BUFFE... | [{"datasets":["SAAFEC_S1262.csv"],"id":36303,"numValue":3.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":36304,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7656,"numValue":9.0,"position":70,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6170 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,170 | train | mutant | 1,577 | 76 | 1,776 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G71A | G71A | 1 | 1 | 0 | 0 | 71 | G | A | 8 | CONSERVATION | 1BPI | 57 | null | 71 | A | L | false | false | 0.295561 | 5.1375 | 2,969 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:G36A | 23.8 | -15.4 | null | null | 31 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10772,"numValue":23.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10773,"numValue":-15.4,"references":[],"strValue":null,"type":"DTM"},{... | [{"id":7657,"numValue":8.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6171 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,171 | train | mutant | 1,577 | 76 | 1,776 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G71A | G71A | 1 | 1 | 0 | 0 | 71 | G | A | 8 | CONSERVATION | 1BPI | 57 | null | 71 | A | L | false | false | 0.295561 | 5.1375 | 3,559 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:G36A | 82.5 | -11.7 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:G36A","type":"_PDB_... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13096,"numValue":82.5,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":13097,"numValue":-11.7,"references":[],"strValue":nu... | [{"id":7657,"numValue":8.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6173 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,173 | train | mutant | 1,645 | 76 | 1,847 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G71S | G71S | 1 | 1 | 0 | 0 | 71 | G | S | 8 | CONSERVATION | 1BPI | 57 | null | 71 | A | L | false | false | 0.295561 | 5.1375 | 3,078 | ProTherm | 4.6 | CD | Thermal | citrate | 5 mM | null | 1BPI_A:G36S | 67.9 | -4.5 | null | null | null | null | 51 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 279 | ARTICLE | Designed replacement of an internal hydration water molecule in BPTI: structural and functional implications of a glycine-to-serine mutation. | 1,993 | 10.1021/bi00068a012 | 7683491 | Biochemistry;32;4564-70 | 4 | Berndt K D|Beunink J|Schr?der W|W?thrich K | [{"numValue":4.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"citrate","type":"BUFFER"},{"numValue":null,"strValue":"5 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:G36S","type":"_PDB_C... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":11193,"numValue":67.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","STRUM_Q3421.csv"],"id":11194,"numValue":-4.5,"references":[],"strValue":null,"type":"DTM"},{"dat... | [{"id":7657,"numValue":8.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6174 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,174 | train | mutant | 1,645 | 76 | 1,847 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G71S | G71S | 1 | 1 | 0 | 0 | 71 | G | S | 8 | CONSERVATION | 1BPI | 57 | null | 71 | A | L | false | false | 0.295561 | 5.1375 | 6,609 | ProTherm | 4.6 | CD | Thermal | citrate | 5 mM | 72.6 | 1BPI_A:G36S | null | null | null | 0.7 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 279 | ARTICLE | Designed replacement of an internal hydration water molecule in BPTI: structural and functional implications of a glycine-to-serine mutation. | 1,993 | 10.1021/bi00068a012 | 7683491 | Biochemistry;32;4564-70 | 4 | Berndt K D|Beunink J|Schr?der W|W?thrich K | [{"numValue":4.6,"strValue":null,"type":"PH"},{"numValue":72.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"citrate","type":"BUFFER"},{"numValue":null,"strValue":"5 mM","type":"BUFFER_CONC... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":23593,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":23594,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7657,"numValue":8.0,"position":71,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6176 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,176 | train | mutant | 1,578 | 76 | 1,777 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G72A | G72A | 1 | 1 | 0 | 0 | 72 | G | A | 9 | CONSERVATION | 1BPI | 57 | null | 72 | A | S | false | false | 36.140744 | 6.7575 | 2,970 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:G37A | 22 | -17.2 | null | null | 34 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":[],"id":10776,"numValue":22.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":10777,"numValue":-17.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":10778,"numValue":34.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],... | [{"id":7658,"numValue":9.0,"position":72,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6177 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,177 | train | mutant | 1,578 | 76 | 1,777 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G72A | G72A | 1 | 1 | 0 | 0 | 72 | G | A | 9 | CONSERVATION | 1BPI | 57 | null | 72 | A | S | false | false | 36.140744 | 6.7575 | 2,985 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:G37A | 66 | -21 | null | null | 47 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":10835,"numValue":66.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":10836,"numValue":-21.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":10837,"numValue":47.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],... | [{"id":7658,"numValue":9.0,"position":72,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6178 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,178 | train | mutant | 1,578 | 76 | 1,777 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G72A | G72A | 1 | 1 | 0 | 0 | 72 | G | A | 9 | CONSERVATION | 1BPI | 57 | null | 72 | A | S | false | false | 36.140744 | 6.7575 | 3,558 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:G37A | 90 | -4.2 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1925.csv|AUTOMUTE_S1962.csv|EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:G37A","type":"_PDB_... | [{"datasets":["AUTOMUTE_S1925.csv","AUTOMUTE_S1962.csv","EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S1810.csv","M47andM8_S2760.csv","PON-TStab_dataset.csv","Saraboji_S2204.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],"id"... | [{"id":7658,"numValue":9.0,"position":72,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6179 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,179 | train | mutant | 1,578 | 76 | 1,777 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G72A | G72A | 1 | 1 | 0 | 0 | 72 | G | A | 9 | CONSERVATION | 1BPI | 57 | null | 72 | A | S | false | false | 36.140744 | 6.7575 | 8,189 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:G37A | null | null | null | 2.3 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv"],"id":27768,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27769,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7658,"numValue":9.0,"position":72,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6180 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,180 | train | mutant | 1,578 | 76 | 1,777 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | G72A | G72A | 1 | 1 | 0 | 0 | 72 | G | A | 9 | CONSERVATION | 1BPI | 57 | null | 72 | A | S | false | false | 36.140744 | 6.7575 | 8,763 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 M | 1BPI_A:G37A | null | null | 4.1 | 4.9 | null | 0.7 | null | null | null | null | null | null | null | null | null | null | Unknown | DCP|DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":29603,"numValue":0.7,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29604,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv"],"id":29605,"numValue":4.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":29606,"numValu... | [{"id":7658,"numValue":9.0,"position":72,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6184 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,184 | train | mutant | 461 | 76 | 510 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | R74M | R74M | 1 | 1 | 0 | 0 | 74 | R | M | 2 | CONSERVATION | 1BPI | 57 | null | 74 | A | S | false | false | 190.612925 | 15.307273 | 754 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:R39M | 100.8 | null | null | null | 75 | null | 74.8 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | AUTOMUTE_S1925.csv|EASE-MM_S1676.csv|HotMuSiC_S1626.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PON-TStab_dataset.csv|Saraboji_S1396.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:R39M","type":"_... | [{"datasets":[],"id":2883,"numValue":100.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","HotMuSiC_S1626.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S2760.csv","PON-TStab_dataset.csv","Saraboji_S1396.csv","SVM-WIN31_SVM-3D12... | [{"id":7660,"numValue":2.0,"position":74,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6186 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,186 | train | mutant | 1,579 | 76 | 1,778 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | R74A | R74A | 1 | 1 | 0 | 0 | 74 | R | A | 2 | CONSERVATION | 1BPI | 57 | null | 74 | A | S | false | false | 190.612925 | 15.307273 | 2,971 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:R39A | 39.2 | 0 | null | null | 41 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv|AUTOMUTE_S1749.csv|EASE-MM_S543.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S1791.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1962.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":10780,"numValue":39.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","capriotti_S1615_map.csv","EASE-MM_S543.csv","guerios_625_map.csv","khan_protherm_da... | [{"id":7660,"numValue":2.0,"position":74,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6189 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,189 | train | mutant | 1,580 | 76 | 1,779 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K76A | K76A | 1 | 1 | 0 | 0 | 76 | K | A | 8 | CONSERVATION | 1BPI | 57 | null | 76 | A | L | true | false | 97.990285 | 9.518889 | 2,972 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:K41A | 36.2 | -3 | null | null | 34 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Broom_S605.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10784,"numValue":36.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Broom_S605.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10785,"numValue":-3.0,"references":[],"strValue":null,"t... | [{"id":7662,"numValue":8.0,"position":76,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6190 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,190 | train | mutant | 1,580 | 76 | 1,779 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K76A | K76A | 1 | 1 | 0 | 0 | 76 | K | A | 8 | CONSERVATION | 1BPI | 57 | null | 76 | A | L | true | false | 97.990285 | 9.518889 | 8,191 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:K41A | null | null | null | 0.4 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27772,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27773,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7662,"numValue":8.0,"position":76,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6191 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,191 | train | mutant | 1,581 | 76 | 1,780 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | R77A | R77A | 1 | 1 | 0 | 0 | 77 | R | A | 4 | CONSERVATION | 1BPI | 57 | null | 77 | A | S | false | false | 164.406628 | 13.063636 | 2,973 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:R42A | 35.6 | -3.6 | null | null | 40 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|EASE-MM_S543.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","EASE-MM_S543.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10788,"numValue":35.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10789,"n... | [{"id":7663,"numValue":4.0,"position":77,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6192 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,192 | train | mutant | 1,581 | 76 | 1,780 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | R77A | R77A | 1 | 1 | 0 | 0 | 77 | R | A | 4 | CONSERVATION | 1BPI | 57 | null | 77 | A | S | false | false | 164.406628 | 13.063636 | 8,192 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:R42A | null | null | null | 0.5 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27774,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27775,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7663,"numValue":4.0,"position":77,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6193 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,193 | train | mutant | 876 | 76 | 991 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N78G | N78G | 1 | 1 | 0 | 0 | 78 | N | G | 9 | CONSERVATION | 1BPI | 57 | null | 78 | A | S | true | false | 1.845211 | 4.5975 | 1,509 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:N43G | 55 | -32 | null | null | 46 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":5524,"numValue":55.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":5525,"numValue":-32.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":5526,"numValue":46.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id... | [{"id":7664,"numValue":9.0,"position":78,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6194 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,194 | train | mutant | 876 | 76 | 991 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N78G | N78G | 1 | 1 | 0 | 0 | 78 | N | G | 9 | CONSERVATION | 1BPI | 57 | null | 78 | A | S | true | false | 1.845211 | 4.5975 | 2,986 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:N43G | 55 | -32 | null | null | 46 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10839,"numValue":55.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":10840,"numValue":-32.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOM... | [{"id":7664,"numValue":9.0,"position":78,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6195 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,195 | train | mutant | 876 | 76 | 991 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N78G | N78G | 1 | 1 | 0 | 0 | 78 | N | G | 9 | CONSERVATION | 1BPI | 57 | null | 78 | A | S | true | false | 1.845211 | 4.5975 | 8,764 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 M | 1BPI_A:N43G | null | null | 3.3 | 5.7 | null | 0.7 | null | null | null | null | null | null | null | null | null | null | Unknown | DCP|DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":29607,"numValue":0.7,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29608,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":29609,"numValue":5.7,"references":... | [{"id":7664,"numValue":9.0,"position":78,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6196 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,196 | train | mutant | 876 | 76 | 991 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N78G | N78G | 1 | 1 | 0 | 0 | 78 | N | G | 9 | CONSERVATION | 1BPI | 57 | null | 78 | A | S | true | false | 1.845211 | 4.5975 | 9,242 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 N | 1BPI_A:N43G | null | null | 3.3 | 5.7 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":31563,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":31564,"numValue":5.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":31565,"numValue":null,"references"... | [{"id":7664,"numValue":9.0,"position":78,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6197 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,197 | train | mutant | 1,582 | 76 | 1,781 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N79A | N79A | 1 | 1 | 0 | 0 | 79 | N | A | 8 | CONSERVATION | 1BPI | 57 | null | 79 | A | L | true | false | 21.765702 | 4.5075 | 2,974 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:N44A | 15 | -29 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|REVERSIBILITY | AUTOMUTE_S1962.csv|Broom_S605.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10792,"numValue":15.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":10793,"numValue":-29.0,"references":[],"strValue":null,"type":"DTM"},{... | [{"id":7665,"numValue":8.0,"position":79,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6198 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,198 | train | mutant | 1,582 | 76 | 1,781 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N79A | N79A | 1 | 1 | 0 | 0 | 79 | N | A | 8 | CONSERVATION | 1BPI | 57 | null | 79 | A | L | true | false | 21.765702 | 4.5075 | 8,193 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:N44A | null | null | null | 3.3 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27776,"numValue":3.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27777,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7665,"numValue":8.0,"position":79,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6199 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,199 | train | mutant | 1,592 | 76 | 1,791 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N79G | N79G | 1 | 1 | 0 | 0 | 79 | N | G | 8 | CONSERVATION | 1BPI | 57 | null | 79 | A | L | true | false | 21.765702 | 4.5075 | 2,987 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:N44G | 66 | -21 | null | null | 49 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10843,"numValue":66.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":10844,"numValue":-21.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOM... | [{"id":7665,"numValue":8.0,"position":79,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6200 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,200 | train | mutant | 1,592 | 76 | 1,791 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | N79G | N79G | 1 | 1 | 0 | 0 | 79 | N | G | 8 | CONSERVATION | 1BPI | 57 | null | 79 | A | L | true | false | 21.765702 | 4.5075 | 8,765 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 M | 1BPI_A:N44G | null | null | 4.3 | 4.7 | null | 0.7 | null | null | null | null | null | null | null | null | null | null | Unknown | DCP|DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 263 | ARTICLE | Hydrogen exchange identifies native-state motional domains important in protein folding. | 1,993 | 10.1021/bi00088a012 | 7690587 | Biochemistry;32;9600-8 | 3 | Kim K S|Fuchs J A|Woodward C K | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":29611,"numValue":0.7,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":29612,"numValue":4.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":29613,"numValue":4.7,"references":... | [{"id":7665,"numValue":8.0,"position":79,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6201 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,201 | train | mutant | 877 | 76 | 992 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F80A | F80A | 1 | 1 | 0 | 0 | 80 | F | A | 9 | CONSERVATION | 1BPI | 57 | null | 80 | A | B | false | false | 20.7836 | 5.191818 | 1,510 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | null | NaCl | 0.1 N | 1BPI_A:F45A | 49 | -38 | null | null | 36 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{... | [{"datasets":[],"id":5528,"numValue":49.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":5529,"numValue":-38.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":5530,"numValue":36.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id... | [{"id":7666,"numValue":9.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6202 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,202 | train | mutant | 877 | 76 | 992 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F80A | F80A | 1 | 1 | 0 | 0 | 80 | F | A | 9 | CONSERVATION | 1BPI | 57 | null | 80 | A | B | false | false | 20.7836 | 5.191818 | 9,243 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 25 | NaCl | 0.1 N | 1BPI_A:F45A | null | null | 2.1 | 6.9 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|DDG|REVERSIBILITY | capriotti_S1615_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 166 | ARTICLE | Crevice-forming mutants of bovine pancreatic trypsin inhibitor: stability changes and new hydrophobic surface. | 1,993 | 10.1002/pro.5560020410 | 7686069 | Protein Sci;2;588-96 | 5 | Fuchs J|Kim K S|Tao F|Danishefsky A T|Housset D | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":31566,"numValue":2.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["capriotti_S1615_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":31567,"numValue":6.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":31568,"numValue":null,"references"... | [{"id":7666,"numValue":9.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6203 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,203 | train | mutant | 877 | 76 | 992 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F80A | F80A | 1 | 1 | 0 | 0 | 80 | F | A | 9 | CONSERVATION | 1BPI | 57 | null | 80 | A | B | false | false | 20.7836 | 5.191818 | 12,789 | ProTherm | 2 | CD | GdnHCl | glycine | 20 mM | 20 | 1BPI_A:F45A | null | null | 2.2 | 6.8 | null | null | null | 2.7 | 0.83 | null | null | null | null | null | null | null | yes (>90%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 822 | ARTICLE | Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding. | 2,002 | 10.1021/bi0116947 | 11841216 | Biochemistry;41;2246-53 | 3 | Li Renhao|Battiste John L|Woodward Clare | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"glycine","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC... | [{"datasets":[],"id":46472,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46473,"numValue":6.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46474,"numValue":0.83,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46475,"numValue":2.7,"references":[],"st... | [{"id":7666,"numValue":9.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6204 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,204 | train | mutant | 4,821 | 76 | 5,362 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | F80L | F80L | 1 | 1 | 0 | 0 | 80 | F | L | 9 | CONSERVATION | 1BPI | 57 | null | 80 | A | B | false | false | 20.7836 | 5.191818 | 11,328 | ProTherm | 8.7 | Gel electrophoresis | Urea | Tris-HCl | 0.1 M | 25 | KCl | 0.2 M | 1BPI_A:F45L | null | null | 6.3 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 755 | ARTICLE | Mutational analysis of the BPTI folding pathway: II. Effects of aromatic-->leucine substitutions on folding kinetics and thermodynamics. | 1,997 | 10.1002/pro.5560060720 | 9232657 | Protein Sci;6;1563-76 | 2 | Goldenberg D P|Zhang J X | [{"numValue":8.7,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Gel electrophoresis","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Tris-HCl","type":"BUFFER"},{"numValue":null,"strValue":"0.1 M","ty... | [{"datasets":[],"id":38996,"numValue":6.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38997,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7666,"numValue":9.0,"position":80,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:6205 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,205 | train | mutant | 465 | 76 | 514 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K81M | K81M | 1 | 1 | 0 | 0 | 81 | K | M | 4 | CONSERVATION | 1BPI | 57 | null | 81 | A | S | false | false | 161.299361 | 7.976667 | 758 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:K46M | 100 | null | null | null | 80.2 | null | 82.2 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:K46M","type":"_... | [{"datasets":[],"id":2899,"numValue":100.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":2900,"numValue":80.2,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":2901,"numValue":82.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":2902,"numValue":null,"references":[],"... | [{"id":7667,"numValue":4.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6206 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,206 | train | mutant | 465 | 76 | 514 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K81M | K81M | 1 | 1 | 0 | 0 | 81 | K | M | 4 | CONSERVATION | 1BPI | 57 | null | 81 | A | S | false | false | 161.299361 | 7.976667 | 8,856 | ProTherm | 4.3 | DSC | Thermal | GlyGly/HCl | 10 mM | 25 | 1BPI_A:K46M | null | null | 13.8 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GlyGly/HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER... | [{"datasets":[],"id":29999,"numValue":13.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30000,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7667,"numValue":4.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6207 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,207 | train | mutant | 1,583 | 76 | 1,782 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K81A | K81A | 1 | 1 | 0 | 0 | 81 | K | A | 4 | CONSERVATION | 1BPI | 57 | null | 81 | A | S | false | false | 161.299361 | 7.976667 | 2,975 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:K46A | 39.8 | 0.6 | null | null | 42 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|STRUM_Q306.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":10795,"numValue":39.8,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q306.csv","STRUM_Q3421.csv"],"id":10796,"numValue":0.6,"references":[],"strValue":null,... | [{"id":7667,"numValue":4.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6208 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,208 | train | mutant | 1,583 | 76 | 1,782 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | K81A | K81A | 1 | 1 | 0 | 0 | 81 | K | A | 4 | CONSERVATION | 1BPI | 57 | null | 81 | A | S | false | false | 161.299361 | 7.976667 | 3,568 | ProTherm | 3 | CD | Thermal | NaH2PO4 | 10 mM | null | 1BPI_A:K46A | 94.2 | 0 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 327 | ARTICLE | Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin. | 1,996 | 10.1021/bi960515w | 8784199 | Biochemistry;35;11435-46 | 2 | Anderson S|Castro M J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:K46A","type":"_PDB_... | [{"datasets":[],"id":13123,"numValue":94.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":13124,"numValue":0.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":13125,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7667,"numValue":4.0,"position":81,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:6210 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,210 | train | mutant | 1,584 | 76 | 1,783 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | S82A | S82A | 1 | 1 | 0 | 0 | 82 | S | A | 7 | CONSERVATION | 1BPI | 57 | null | 82 | A | S | false | false | 32.490674 | 5.271667 | 2,976 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:S47A | 27.3 | -11.9 | null | null | 42 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q306.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q306.csv","STRUM_Q3421.csv"],"id":10799,"numValue":27.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv"],"id":10800,"numValue":-11.9,"references":[],"strValue":nul... | [{"id":7668,"numValue":7.0,"position":82,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6211 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,211 | train | mutant | 1,584 | 76 | 1,783 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | S82A | S82A | 1 | 1 | 0 | 0 | 82 | S | A | 7 | CONSERVATION | 1BPI | 57 | null | 82 | A | S | false | false | 32.490674 | 5.271667 | 8,195 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:S47A | null | null | null | 1.6 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27780,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27781,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7668,"numValue":7.0,"position":82,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6212 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,212 | train | mutant | 462 | 76 | 511 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | E84M | E84M | 1 | 1 | 0 | 0 | 84 | E | M | 5 | CONSERVATION | 1BPI | 57 | null | 84 | A | H | false | false | 114.218785 | 7.6 | 755 | ProTherm | 4.3 | DSC | Thermal | acetate/Na | 10 mM | null | 1BPI_A:E49M | 98 | null | null | null | 77.8 | null | 76 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"acetate/Na","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:E49M","type":"_... | [{"datasets":[],"id":2887,"numValue":98.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":2888,"numValue":77.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":2889,"numValue":76.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":2890,"numValue":null,"references":[],"s... | [{"id":7670,"numValue":5.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6213 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,213 | train | mutant | 462 | 76 | 511 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | E84M | E84M | 1 | 1 | 0 | 0 | 84 | E | M | 5 | CONSERVATION | 1BPI | 57 | null | 84 | A | H | false | false | 114.218785 | 7.6 | 8,857 | ProTherm | 4.3 | DSC | Thermal | GlyGly/HCl | 10 mM | 25 | 1BPI_A:E49M | null | null | 12.6 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 84 | ARTICLE | Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI). | 2,002 | 10.1110/ps.4460102 | 11910035 | Protein Sci;11;924-32 | 3 | Buczek Olga|Krowarsch Daniel|Otlewski Jacek | [{"numValue":4.3,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GlyGly/HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER... | [{"datasets":[],"id":30001,"numValue":12.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30002,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7670,"numValue":5.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6214 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,214 | train | mutant | 1,585 | 76 | 1,784 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 5 | CONSERVATION | 1BPI | 57 | null | 84 | A | H | false | false | 114.218785 | 7.6 | 2,977 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:E49A | 37.9 | -1.3 | null | null | 43 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":[],"id":10803,"numValue":37.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":10804,"numValue":-1.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":10805,"numValue":43.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"... | [{"id":7670,"numValue":5.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6215 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,215 | train | mutant | 1,585 | 76 | 1,784 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | E84A | E84A | 1 | 1 | 0 | 0 | 84 | E | A | 5 | CONSERVATION | 1BPI | 57 | null | 84 | A | H | false | false | 114.218785 | 7.6 | 8,196 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:E49A | null | null | null | 0.2 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27782,"numValue":0.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27783,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7670,"numValue":5.0,"position":84,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6216 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,216 | train | mutant | 1,586 | 76 | 1,785 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | D85A | D85A | 1 | 1 | 0 | 0 | 85 | D | A | 5 | CONSERVATION | 1BPI | 57 | null | 85 | A | H | false | false | 51.450897 | 6.86625 | 2,978 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | null | NaCl | 150 mM | 1BPI_A:D50A | 36.6 | -2.6 | null | null | 44 | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DH|REVERSIBILITY | AUTOMUTE_S1749.csv|AUTOMUTE_S1962.csv|Saraboji_S1791.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1925.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|Saraboji_S1396.csv|EASE-MM_S1676.csv|PON-TStab_dataset.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"n... | [{"datasets":[],"id":10807,"numValue":36.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","AUTOMUTE_S1962.csv","Saraboji_S1791.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":10808,"numValue":-2.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1925.csv","I_Mutant... | [{"id":7671,"numValue":5.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6217 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,217 | train | mutant | 1,586 | 76 | 1,785 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | D85A | D85A | 1 | 1 | 0 | 0 | 85 | D | A | 5 | CONSERVATION | 1BPI | 57 | null | 85 | A | H | false | false | 51.450897 | 6.86625 | 8,197 | ProTherm | 7 | DSC | Thermal | phosphate | 10 mM | 39 | NaCl | 150 mM | 1BPI_A:D50A | null | null | null | 0.4 | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DDG|REVERSIBILITY | capriotti_S1615_map.csv|guerios_625_map.csv|khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 262 | ARTICLE | Contribution of individual side-chains to the stability of BPTI examined by alanine-scanning mutagenesis. | 1,995 | 10.1006/jmbi.1995.0304 | 7540212 | J Mol Biol;249;388-97 | 3 | Yu M H|Weissman J S|Kim P S | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":39.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_... | [{"datasets":["capriotti_S1615_map.csv","guerios_625_map.csv","khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27784,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27785,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7671,"numValue":5.0,"position":85,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6219 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,219 | train | mutant | 83 | 76 | 92 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | M87L | M87L | 1 | 1 | 0 | 0 | 87 | M | L | 5 | CONSERVATION | 1BPI | 57 | null | 87 | A | H | false | false | 122.639795 | 7.6475 | 127 | ProTherm | 2.5 | DSC | Thermal | glycine-HCl | 10 mM | null | 1BPI_A:M52L | 86.3 | null | null | null | 70 | 0.3 | 67.8 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DCP|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 11 | ARTICLE | Amino-acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability. | 2,001 | 10.1110/ps.38101 | 11274462 | Protein Sci;10;715-24 | 2 | Krowarsch D|Otlewski J | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:M52L","type":"... | [{"datasets":[],"id":502,"numValue":86.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":503,"numValue":70.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":504,"numValue":0.3,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":505,"numValue":67.8,"references":[],"strValu... | [{"id":7673,"numValue":5.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6220 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,220 | train | mutant | 83 | 76 | 92 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | M87L | M87L | 1 | 1 | 0 | 0 | 87 | M | L | 5 | CONSERVATION | 1BPI | 57 | null | 87 | A | H | false | false | 122.639795 | 7.6475 | 128 | ProTherm | 3 | DSC | Thermal | glycine-HCl | 10 mM | null | 1BPI_A:M52L | 91.7 | null | null | null | 71 | 0.35 | 69.8 | null | null | null | null | null | null | null | null | null | yes | TM|DH|DCP|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 11 | ARTICLE | Amino-acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability. | 2,001 | 10.1110/ps.38101 | 11274462 | Protein Sci;10;715-24 | 2 | Krowarsch D|Otlewski J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1BPI_A:M52L","type":"... | [{"datasets":[],"id":507,"numValue":91.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":508,"numValue":71.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":509,"numValue":0.35,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":510,"numValue":69.8,"references":[],"strVal... | [{"id":7673,"numValue":5.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6222 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,222 | train | mutant | 83 | 76 | 92 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | M87L | M87L | 1 | 1 | 0 | 0 | 87 | M | L | 5 | CONSERVATION | 1BPI | 57 | null | 87 | A | H | false | false | 122.639795 | 7.6475 | 6,466 | ProTherm | 3 | DSC | Thermal | glycine-HCl | 10 mM | 89 | 1BPI_A:M52L | null | null | 0.49 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 11 | ARTICLE | Amino-acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability. | 2,001 | 10.1110/ps.38101 | 11274462 | Protein Sci;10;715-24 | 2 | Krowarsch D|Otlewski J | [{"numValue":3.0,"strValue":null,"type":"PH"},{"numValue":89.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":23208,"numValue":0.49,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":23209,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7673,"numValue":5.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6223 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,223 | train | mutant | 83 | 76 | 92 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | M87L | M87L | 1 | 1 | 0 | 0 | 87 | M | L | 5 | CONSERVATION | 1BPI | 57 | null | 87 | A | H | false | false | 122.639795 | 7.6475 | 6,485 | ProTherm | 2.5 | DSC | Thermal | glycine-HCl | 10 mM | 83 | 1BPI_A:M52L | null | null | 0.6 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 11 | ARTICLE | Amino-acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability. | 2,001 | 10.1110/ps.38101 | 11274462 | Protein Sci;10;715-24 | 2 | Krowarsch D|Otlewski J | [{"numValue":2.5,"strValue":null,"type":"PH"},{"numValue":83.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":23250,"numValue":0.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":23251,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7673,"numValue":5.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:6224 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,224 | train | mutant | 83 | 76 | 92 | 100 | 100 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | 9 | Pancreatic trypsin inhibitor | Bos taurus | 1 | P00974 | IPR002223|IPR036880|IPR020901|IPR050098 | M87L | M87L | 1 | 1 | 0 | 0 | 87 | M | L | 5 | CONSERVATION | 1BPI | 57 | null | 87 | A | H | false | false | 122.639795 | 7.6475 | 6,516 | ProTherm | 2 | DSC | Thermal | glycine-HCl | 10 mM | 81 | 1BPI_A:M52L | null | null | 0.44 | null | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 11 | ARTICLE | Amino-acid substitutions at the fully exposed P1 site of bovine pancreatic trypsin inhibitor affect its stability. | 2,001 | 10.1110/ps.38101 | 11274462 | Protein Sci;10;715-24 | 2 | Krowarsch D|Otlewski J | [{"numValue":2.0,"strValue":null,"type":"PH"},{"numValue":81.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"glycine-HCl","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFE... | [{"datasets":[],"id":23336,"numValue":0.44,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":23337,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7673,"numValue":5.0,"position":87,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] |
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