row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:6448 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,448 | train | mutant | 1,275 | 117 | 1,425 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101F | D101F | 1 | 1 | 0 | 0 | 101 | D | F | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 2,439 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:D19F | 48.1 | -4.6 | null | null | null | null | 99 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|Broom_S605.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":8966,"numValue":48.1,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":8967,"numValue":-4.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6450 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,450 | train | mutant | 1,275 | 117 | 1,425 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101F | D101F | 1 | 1 | 0 | 0 | 101 | D | F | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 13,333 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D19F | null | null | 4 | 1.5 | null | null | null | 0.67 | 0.9 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 845 | ARTICLE | Stability effects of increasing the hydrophobicity of solvent-exposed side chains in staphylococcal nuclease. | 1,998 | 10.1021/bi9725069 | 9578580 | Biochemistry;37;6939-48 | 4 | Stites W E|Schwehm J M|Kristyanne E S|Biggers C C | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49020,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":49021,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49022,"numValue":0.9,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":49023,"numValue":0.67,"... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6451 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,451 | train | mutant | 5,944 | 117 | 6,514 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101A | D101A | 1 | 1 | 0 | 0 | 101 | D | A | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 12,812 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D19A | null | null | 5.5 | 0.1 | null | null | null | 0.79 | 1 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46576,"numValue":5.5,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46577,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46578,"numValue":1.0,"references"... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6453 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,453 | train | mutant | 5,945 | 117 | 6,515 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101G | D101G | 1 | 1 | 0 | 0 | 101 | D | G | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 12,813 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D19G | null | null | 5.1 | 0.5 | null | null | null | 0.74 | 1 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46581,"numValue":5.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":46582,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46583,"numValue":1.0,"references":[],"strValue":nul... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6454 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,454 | train | mutant | 5,945 | 117 | 6,515 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101G | D101G | 1 | 1 | 0 | 0 | 101 | D | G | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 13,573 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D19G | null | null | 5.1 | 0.3 | null | null | null | 0.73 | 1.04 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 856 | ARTICLE | Evidence for strained interactions between side-chains and the polypeptide backbone. | 1,994 | 10.1016/s0022-2836(05)80008-7 | 8289248 | J Mol Biol;235;27-32 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50195,"numValue":5.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S983.csv"],"id":50196,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":50197,"numValue":1.04,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":50198,"numValue":0.73,"... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6455 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,455 | train | mutant | 6,043 | 117 | 6,628 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101K | D101K | 1 | 1 | 0 | 0 | 101 | D | K | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 12,918 | ProTherm | 7 | Fluorescence | GdnHCl | sodium phosphate | 25 mM | 20 | sodium chloride | 100 mM | 1STN_A:D19K | null | null | 5.1 | 0.3 | null | null | null | 0.74 | 6.93 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 828 | ARTICLE | Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects. | 2,003 | 10.1021/bi0266434 | 12549934 | Biochemistry;42;1118-28 | 5 | Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47106,"numValue":5.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47107,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47108,"numValue":6.93,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4710... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6456 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,456 | train | mutant | 6,044 | 117 | 6,629 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D101N | D101N | 1 | 1 | 0 | 0 | 101 | D | N | 9 | CONSERVATION | 1STN | 140 | null | 101 | A | E | false | false | 5.116371 | 16.81375 | 12,919 | ProTherm | 7 | Fluorescence | GdnHCl | sodium phosphate | 25 mM | 20 | sodium chloride | 100 mM | 1STN_A:D19N | null | null | 5.2 | 0.2 | null | null | null | 0.87 | 5.94 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 828 | ARTICLE | Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects. | 2,003 | 10.1021/bi0266434 | 12549934 | Biochemistry;42;1118-28 | 5 | Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47111,"numValue":5.2,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47112,"numValue":0.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47113,"numValue":5.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4711... | [{"id":7871,"numValue":9.0,"position":101,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6457 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,457 | train | mutant | 6,124 | 117 | 6,712 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102A | G102A | 1 | 1 | 0 | 0 | 102 | G | A | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,036 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:G20A | null | null | 5.2 | 0.3 | null | null | null | 0.81 | 0.94 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47651,"numValue":5.2,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":47652,"numValue":0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47653,"numValue":0.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4765... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6458 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,458 | train | mutant | 6,125 | 117 | 6,713 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102V | G102V | 1 | 1 | 0 | 0 | 102 | G | V | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,037 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:G20V | null | null | 3.2 | 2.3 | null | null | null | 0.5 | 0.93 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47656,"numValue":3.2,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":47657,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47658,"numValue":0.93,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":47659,"numValue":0.5,"... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6459 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,459 | train | mutant | 6,201 | 117 | 6,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102E | G102E | 1 | 1 | 0 | 0 | 102 | G | E | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,155 | ProTherm | 3.9 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:G20E | null | null | 6.3 | 3.2 | null | null | null | 1.3 | 4.7 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":3.9,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48157,"numValue":6.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S983.csv"],"id":48158,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48159,"numValue":4.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48160,"numValue":1.3,"re... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6460 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,460 | train | mutant | 6,201 | 117 | 6,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102E | G102E | 1 | 1 | 0 | 0 | 102 | G | E | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,156 | ProTherm | 4.9 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:G20E | null | null | 8.2 | 3.5 | null | null | null | 1.6 | 5.1 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":4.9,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48162,"numValue":8.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48163,"numValue":3.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48164,"numValue":5.1,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48165,"numValue":1.6,"references":[],"str... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6461 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,461 | train | mutant | 6,201 | 117 | 6,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102E | G102E | 1 | 1 | 0 | 0 | 102 | G | E | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,157 | ProTherm | 6 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:G20E | null | null | 8 | 3.7 | null | null | null | 1.5 | 5.2 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48167,"numValue":8.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":48168,"numValue":3.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48169,"numValue":5.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48170,"numValue":1.5,"r... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6462 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,462 | train | mutant | 6,201 | 117 | 6,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102E | G102E | 1 | 1 | 0 | 0 | 102 | G | E | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,158 | ProTherm | 7.9 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:G20E | null | null | 7.8 | 4.1 | null | null | null | 1.5 | 5.1 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":7.9,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48172,"numValue":7.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48173,"numValue":4.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48174,"numValue":5.1,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48175,"numValue":1.5,"references":[],"str... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6463 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,463 | train | mutant | 6,201 | 117 | 6,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | G102E | G102E | 1 | 1 | 0 | 0 | 102 | G | E | 9 | CONSERVATION | 1STN | 140 | null | 102 | A | T | true | false | 0 | 10.09 | 13,159 | ProTherm | 9.1 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:G20E | null | null | 7.8 | 3.8 | null | null | null | 1.5 | 5.2 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":9.1,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48177,"numValue":7.8,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":48178,"numValue":3.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48179,"numValue":5.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48180,"numValue":1.5,"r... | [{"id":7872,"numValue":9.0,"position":102,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6464 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,464 | train | mutant | 2,192 | 117 | 2,489 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103K | D103K | 1 | 1 | 0 | 0 | 103 | D | K | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 4,334 | ProTherm | 7 | Fluorescence | Thermal | Sodium phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:D21K | 61.2 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | TM|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 415 | ARTICLE | Increasing the thermostability of staphylococcal nuclease: implications for the origin of protein thermostability. | 2,000 | 10.1006/jmbi.2000.4140 | 11023780 | J Mol Biol;303;125-30 | 4 | Chen J|Lu Z|Sakon J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","... | [{"datasets":[],"id":16053,"numValue":61.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16054,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6465 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,465 | train | mutant | 2,192 | 117 | 2,489 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103K | D103K | 1 | 1 | 0 | 0 | 103 | D | K | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 12,920 | ProTherm | 7 | Fluorescence | GdnHCl | sodium phosphate | 25 mM | 20 | sodium chloride | 100 mM | 1STN_A:D21K | null | null | 6.4 | -1 | null | null | null | 1.02 | 6.34 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 828 | ARTICLE | Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects. | 2,003 | 10.1021/bi0266434 | 12549934 | Biochemistry;42;1118-28 | 5 | Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47116,"numValue":6.4,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":47117,"numValue":-1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47118,"numValue":6.34,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":47119,"numValue":1.02... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6466 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,466 | train | mutant | 2,192 | 117 | 2,489 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103K | D103K | 1 | 1 | 0 | 0 | 103 | D | K | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 13,619 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21K | null | null | 6.4 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 415 | ARTICLE | Increasing the thermostability of staphylococcal nuclease: implications for the origin of protein thermostability. | 2,000 | 10.1006/jmbi.2000.4140 | 11023780 | J Mol Biol;303;125-30 | 4 | Chen J|Lu Z|Sakon J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50393,"numValue":6.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":50394,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6468 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,468 | train | mutant | 2,193 | 117 | 2,490 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103N | D103N | 1 | 1 | 0 | 0 | 103 | D | N | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 12,921 | ProTherm | 7 | Fluorescence | GdnHCl | sodium phosphate | 25 mM | 20 | sodium chloride | 100 mM | 1STN_A:D21N | null | null | 6.8 | -1.4 | null | null | null | 1.05 | 6.47 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 828 | ARTICLE | Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects. | 2,003 | 10.1021/bi0266434 | 12549934 | Biochemistry;42;1118-28 | 5 | Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47121,"numValue":6.8,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":47122,"numValue":-1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47123,"numValue":6.47,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":47124,"numValue":1.05... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6469 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,469 | train | mutant | 2,193 | 117 | 2,490 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103N | D103N | 1 | 1 | 0 | 0 | 103 | D | N | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 13,620 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21N | null | null | 6.8 | null | null | null | null | null | null | null | null | null | null | null | null | null | Unknown | DG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 415 | ARTICLE | Increasing the thermostability of staphylococcal nuclease: implications for the origin of protein thermostability. | 2,000 | 10.1006/jmbi.2000.4140 | 11023780 | J Mol Biol;303;125-30 | 4 | Chen J|Lu Z|Sakon J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50395,"numValue":6.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":50396,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6470 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,470 | train | mutant | 5,946 | 117 | 6,516 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103A | D103A | 1 | 1 | 0 | 0 | 103 | D | A | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 12,814 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21A | null | null | 6.3 | -0.7 | null | null | null | 0.94 | 0.96 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46586,"numValue":6.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":46587,"numValue":-0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46588,"numValue":0.96,"references":[],"strValue":n... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6471 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,471 | train | mutant | 5,946 | 117 | 6,516 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103A | D103A | 1 | 1 | 0 | 0 | 103 | D | A | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 13,570 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21A | null | null | 6.1 | -0.7 | null | null | null | 0.94 | 0.96 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 856 | ARTICLE | Evidence for strained interactions between side-chains and the polypeptide backbone. | 1,994 | 10.1016/s0022-2836(05)80008-7 | 8289248 | J Mol Biol;235;27-32 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50180,"numValue":6.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":50181,"numValue":-0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":50182,"numValue":0.96,"references":[],"strValue":n... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6472 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,472 | train | mutant | 5,947 | 117 | 6,517 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103G | D103G | 1 | 1 | 0 | 0 | 103 | D | G | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 12,815 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21G | null | null | 5.9 | -0.3 | null | null | null | 0.89 | 0.96 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 827 | ARTICLE | Contributions of the ionizable amino acids to the stability of staphylococcal nuclease. | 1,996 | 10.1021/bi960171+ | 8639591 | Biochemistry;35;6443-9 | 3 | Shortle D|Garcia-Moreno B|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46591,"numValue":5.9,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46592,"numValue":-0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46593,"numValue":0.96,"reference... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6473 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,473 | train | mutant | 5,947 | 117 | 6,517 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | D103G | D103G | 1 | 1 | 0 | 0 | 103 | D | G | 9 | BINDING_SITE|CONSERVATION | 1STN | 140 | null | 103 | A | T | true | true | 8.66979 | 13.87625 | 13,571 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:D21G | null | null | 5.7 | -0.3 | null | null | null | 0.89 | 0.96 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 856 | ARTICLE | Evidence for strained interactions between side-chains and the polypeptide backbone. | 1,994 | 10.1016/s0022-2836(05)80008-7 | 8289248 | J Mol Biol;235;27-32 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50185,"numValue":5.7,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":50186,"numValue":-0.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":50187,"numValue":0.96,"reference... | [{"id":34,"numValue":null,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"BINDING_SITE"},{"id":7873,"numValue":9.0,"position":103,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6475 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,475 | train | mutant | 1,245 | 117 | 1,395 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104S | T104S | 1 | 1 | 0 | 0 | 104 | T | S | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,504 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22S | 51.5 | -1.5 | null | null | null | null | 83 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":[],"id":9226,"numValue":51.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":9227,"numValue":-1.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9228,"numValue":83.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":9229,"numValue":null,"references":[],"... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6476 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,476 | train | mutant | 1,245 | 117 | 1,395 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104S | T104S | 1 | 1 | 0 | 0 | 104 | T | S | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 13,511 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22S | null | null | 5 | 0.6 | null | null | null | 0.7 | 1.06 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 853 | ARTICLE | Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease. | 1,995 | 10.1021/bi00042a029 | 7577991 | Biochemistry;34;13949-60 | 4 | Stites W E|Byrne M P|Manuel R L|Lowe L G | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49898,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":49899,"numValue":0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49900,"numValue":1.06,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4990... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6477 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,477 | train | mutant | 1,253 | 117 | 1,403 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104V | T104V | 1 | 1 | 0 | 0 | 104 | T | V | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,417 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22V | 49.1 | -3.6 | null | null | null | null | 76 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1925.csv|HotMuSiC_S1626.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|Saraboji_S1396.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv|M47andM8_S1810.csv|AUTOMUTE_S1962.csv|Saraboji_S2204.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":["AUTOMUTE_S1925.csv","HotMuSiC_S1626.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S2760.csv","Saraboji_S1396.csv","SVM-WIN31_SVM-3D12_S1634.csv","SVM-WIN31_SVM-3D12_S1681.csv"],"id":8878,"numValue":49.1,"references":[],"strValue":null,"type":"TM"},{"datasets":["AU... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6478 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,478 | train | mutant | 1,253 | 117 | 1,403 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104V | T104V | 1 | 1 | 0 | 0 | 104 | T | V | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,512 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22V | 51.3 | -1.7 | null | null | null | null | 77 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | STRUM_Q306.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["STRUM_Q306.csv","STRUM_Q3421.csv"],"id":9258,"numValue":51.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["STRUM_Q306.csv","STRUM_Q3421.csv"],"id":9259,"numValue":-1.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":["STRUM_Q306.csv","STRUM_Q3421.csv"],"id":9260,"numValue":77.0,"re... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6479 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,479 | train | mutant | 1,253 | 117 | 1,403 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104V | T104V | 1 | 1 | 0 | 0 | 104 | T | V | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 13,519 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22V | null | null | 4.7 | 0.9 | null | null | null | 0.71 | 0.99 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 853 | ARTICLE | Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease. | 1,995 | 10.1021/bi00042a029 | 7577991 | Biochemistry;34;13949-60 | 4 | Stites W E|Byrne M P|Manuel R L|Lowe L G | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49938,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49939,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49940,"numValue":0.99,"references":[],"strValue":nu... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6480 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,480 | train | mutant | 1,261 | 117 | 1,411 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104C | T104C | 1 | 1 | 0 | 0 | 104 | T | C | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,425 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22C | 48.9 | -3.8 | null | null | null | null | 74 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":8910,"numValue":48.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":8911,"numValue":-3.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":891... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6481 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,481 | train | mutant | 1,261 | 117 | 1,411 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104C | T104C | 1 | 1 | 0 | 0 | 104 | T | C | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,520 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22C | 51.2 | -1.8 | null | null | null | null | 79 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | Broom_S605.csv|STRUM_Q3421.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["Broom_S605.csv","STRUM_Q3421.csv"],"id":9290,"numValue":51.2,"references":[],"strValue":null,"type":"TM"},{"datasets":["Broom_S605.csv","STRUM_Q3421.csv"],"id":9291,"numValue":-1.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9292,"numValue":79.0,"references":[],"strValue":null,"type... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6482 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,482 | train | mutant | 1,261 | 117 | 1,411 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104C | T104C | 1 | 1 | 0 | 0 | 104 | T | C | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 13,527 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22C | null | null | 4.7 | 0.9 | null | null | null | 0.68 | 1.02 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 853 | ARTICLE | Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease. | 1,995 | 10.1021/bi00042a029 | 7577991 | Biochemistry;34;13949-60 | 4 | Stites W E|Byrne M P|Manuel R L|Lowe L G | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49978,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":49979,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49980,"numValue":1.02,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":49981,"numValue":0.68,... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6483 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,483 | train | mutant | 1,268 | 117 | 1,418 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104I | T104I | 1 | 1 | 0 | 0 | 104 | T | I | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,432 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22I | 49.7 | -3 | null | null | null | null | 74 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | HotMuSiC_S1626.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":["HotMuSiC_S1626.csv"],"id":8938,"numValue":49.7,"references":[],"strValue":null,"type":"TM"},{"datasets":["HotMuSiC_S1626.csv"],"id":8939,"numValue":-3.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["HotMuSiC_S1626.csv"],"id":8940,"numValue":74.0,"references":[],"strValue":null,"type":"DHVH"... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6484 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,484 | train | mutant | 1,268 | 117 | 1,418 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104I | T104I | 1 | 1 | 0 | 0 | 104 | T | I | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 2,527 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:T22I | 49.4 | -3.6 | null | null | null | null | 78 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | Broom_S605.csv|STRUM_Q3421.csv|EASE-MM_S238.csv|PoPMuSiC-2.0_S2648.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["Broom_S605.csv"],"id":9318,"numValue":49.4,"references":[],"strValue":null,"type":"TM"},{"datasets":["STRUM_Q3421.csv"],"id":9319,"numValue":-3.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":["Broom_S605.csv"],"id":9320,"numValue":78.0,"references":[],"strValue":null,"type":"DHVH"},{"dataset... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6485 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,485 | train | mutant | 1,268 | 117 | 1,418 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104I | T104I | 1 | 1 | 0 | 0 | 104 | T | I | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 12,778 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22I | null | null | 4.7 | 0.7 | null | null | null | 0.74 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 821 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines. | 2,001 | 10.1021/bi011267t | 11705391 | Biochemistry;40;13998-4003 | 6 | Chen J|Stites W E|Spencer D S|Byrne M P|Holder J B|Bennett A F | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46417,"numValue":4.7,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":46418,"numValue":0.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46419,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46420,"numValue":0.74,"... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6486 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,486 | train | mutant | 6,169 | 117 | 6,757 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104G | T104G | 1 | 1 | 0 | 0 | 104 | T | G | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 13,085 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22G | null | null | 3.1 | 2.4 | null | null | null | 0.41 | 1.1 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47894,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":47895,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47896,"numValue":1.1,"references":[],"strValue":nul... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6487 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,487 | train | mutant | 6,170 | 117 | 6,758 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | T104A | T104A | 1 | 1 | 0 | 0 | 104 | T | A | 9 | CONSERVATION | 1STN | 140 | null | 104 | A | E | true | true | 10.507478 | 11.005714 | 13,086 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:T22A | null | null | 3.9 | 1.6 | null | null | null | 0.54 | 1.07 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 833 | ARTICLE | Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state. | 1,992 | 10.1021/bi00140a005 | 1610820 | Biochemistry;31;5717-28 | 3 | Shortle D|Meeker A K|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":47899,"numValue":3.9,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":47900,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":47901,"numValue":1.07,"references":[],"strValue":nu... | [{"id":7874,"numValue":9.0,"position":104,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6488 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,488 | train | mutant | 1,217 | 117 | 1,367 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105T | V105T | 1 | 1 | 0 | 0 | 105 | V | T | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 2,380 | ProTherm | 7 | CD | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:V23T | 38 | -14.7 | null | null | null | null | 67 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | Broom_S605.csv|PoPMuSiC-2.0_S2648.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu... | [{"datasets":[],"id":8730,"numValue":38.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["Broom_S605.csv","PoPMuSiC-2.0_S2648.csv"],"id":8731,"numValue":-14.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":["PoPMuSiC-2.0_S2648.csv"],"id":8732,"numValue":67.0,"references":[],"strValue":null,"type":... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6489 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,489 | train | mutant | 1,217 | 117 | 1,367 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105T | V105T | 1 | 1 | 0 | 0 | 105 | V | T | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 2,475 | ProTherm | 7 | Fluorescence | Thermal | Phosphate | 25 mM | null | NaCl | 100 mM | 1STN_A:V23T | 39 | -14 | null | null | null | null | 68 | null | null | null | null | null | null | null | null | null | Unknown | TM|DTM|DHVH|REVERSIBILITY | AUTOMUTE_S1962.csv|Saraboji_S2204.csv|PoPMuSiC-2.0_S2648.csv|STRUM_Q3421.csv|Broom_S605.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 225 | ARTICLE | Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation. | 2,007 | 10.1016/j.bpc.2006.10.014 | 17134819 | Biophys Chem;125;490-6 | 2 | Byrne Michael P|Stites Wesley E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"... | [{"datasets":["AUTOMUTE_S1962.csv","Saraboji_S2204.csv"],"id":9110,"numValue":39.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1962.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":9111,"numValue":-14.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":["Broom_... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6490 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,490 | train | mutant | 1,217 | 117 | 1,367 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105T | V105T | 1 | 1 | 0 | 0 | 105 | V | T | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,478 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23T | null | null | 2.4 | 3.2 | null | null | null | 0.31 | 1.17 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 853 | ARTICLE | Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease. | 1,995 | 10.1021/bi00042a029 | 7577991 | Biochemistry;34;13949-60 | 4 | Stites W E|Byrne M P|Manuel R L|Lowe L G | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49736,"numValue":2.4,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49737,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49738,"numValue":1.17,"references":[],"strValue":nu... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6492 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,492 | train | mutant | 1,602 | 117 | 1,802 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105A | V105A | 1 | 1 | 0 | 0 | 105 | V | A | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 11,078 | ProTherm | 5.6 | Fluorescence | GdnHCl | Sodium acetate | 50 mM | 25 | NaCl | 100 mM | 1STN_A:V23A | null | null | 1.7 | null | null | null | null | null | 8.2 | null | null | null | null | null | null | null | Unknown | DG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 741 | ARTICLE | A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease. | 1,999 | 10.1038/12338 | 10467101 | Nat Struct Biol;6;876-83 | 2 | Wrabl J|Shortle D | [{"numValue":5.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","t... | [{"datasets":[],"id":38137,"numValue":1.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38138,"numValue":8.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38139,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6493 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,493 | train | mutant | 1,602 | 117 | 1,802 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105A | V105A | 1 | 1 | 0 | 0 | 105 | V | A | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 11,079 | ProTherm | 5.2 | Fluorescence | GdnHCl | Sodium acetate | 50 mM | 25 | NaCl | 100 mM | 1STN_A:V23A | null | null | 2.2 | null | null | null | null | null | 7.7 | null | null | null | null | null | null | null | Unknown | DG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 741 | ARTICLE | A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease. | 1,999 | 10.1038/12338 | 10467101 | Nat Struct Biol;6;876-83 | 2 | Wrabl J|Shortle D | [{"numValue":5.2,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","t... | [{"datasets":[],"id":38140,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38141,"numValue":7.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38142,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6494 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,494 | train | mutant | 1,602 | 117 | 1,802 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105A | V105A | 1 | 1 | 0 | 0 | 105 | V | A | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,421 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23A | null | null | 2.58 | 2.9 | null | null | null | 0.3 | 1.18 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 850 | ARTICLE | Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease. | 1,990 | 10.1021/bi00487a007 | 2261461 | Biochemistry;29;8033-41 | 3 | Shortle D|Stites W E|Meeker A K | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":49453,"numValue":2.58,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49454,"numValue":2.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49455,"numValue":1.18,"references":[],"strValue":n... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6495 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,495 | train | mutant | 1,602 | 117 | 1,802 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105A | V105A | 1 | 1 | 0 | 0 | 105 | V | A | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,544 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23A | null | null | 2.6 | null | null | null | null | null | 8.1 | null | null | null | null | null | null | null | Unknown | DG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 741 | ARTICLE | A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease. | 1,999 | 10.1038/12338 | 10467101 | Nat Struct Biol;6;876-83 | 2 | Wrabl J|Shortle D | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":50054,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":50055,"numValue":8.1,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":50056,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6496 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,496 | train | mutant | 1,790 | 117 | 2,004 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F | V105F | 1 | 1 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 3,442 | ProTherm | 5.35 | NMR | Thermal | Unknown | null | NaCl | 0.3 M | 1STN_A:V23F | 37.6 | -10.2 | null | null | null | null | 28.7 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DHVH|REVERSIBILITY | EASE-MM_S1676.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S2760.csv|PoPMuSiC-2.0_S2648.csv|Saraboji_S1396.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S499.csv|AUTOMUTE_S1749.csv|AUTOMUTE_S1962.csv|Saraboji_S1791.csv|Saraboji_S2204.csv|Broom_S605.csv | PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION | 307 | ARTICLE | Coupling between local structure and global stability of a protein: mutants of staphylococcal nuclease. | 1,990 | 10.1021/bi00471a003 | 2372535 | Biochemistry;29;4516-25 | 3 | Alexandrescu A T|Hinck A P|Markley J L | [{"numValue":5.35,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"NMR","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Unknown","type":"BUFFER"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"numValue":null,"strValue":"0.3 M","type":"ION_CONC"},{"numVa... | [{"datasets":["EASE-MM_S1676.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S2760.csv","PoPMuSiC-2.0_S2648.csv","Saraboji_S1396.csv","STRUM_Q3421.csv","SVM-WIN31_SVM-3D12_S499.csv"],"id":12720,"numValue":37.6,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S17... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6497 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,497 | train | mutant | 1,790 | 117 | 2,004 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F | V105F | 1 | 1 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,293 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F | null | null | null | 2.3 | null | null | null | null | 0.84 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | SAAFEC_S1262.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":["SAAFEC_S1262.csv"],"id":48845,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48846,"numValue":0.84,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48847,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6498 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,498 | train | mutant | 5,884 | 117 | 6,454 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I | V105I | 1 | 1 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 12,726 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I | null | null | 5.2 | 0.2 | null | null | null | 0.86 | 6.08 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 821 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines. | 2,001 | 10.1021/bi011267t | 11705391 | Biochemistry;40;13998-4003 | 6 | Chen J|Stites W E|Spencer D S|Byrne M P|Holder J B|Bennett A F | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46157,"numValue":5.2,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46158,"numValue":0.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46159,"numValue":6.08,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4616... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6499 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,499 | train | mutant | 5,885 | 117 | 6,455 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L | V105L | 1 | 1 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 12,727 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L | null | null | 5.3 | 0.1 | null | null | null | 0.83 | 6.39 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | SAAFEC_S1262.csv|SAAFEC_S983.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 821 | ARTICLE | Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines. | 2,001 | 10.1021/bi011267t | 11705391 | Biochemistry;40;13998-4003 | 6 | Chen J|Stites W E|Spencer D S|Byrne M P|Holder J B|Bennett A F | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":46162,"numValue":5.3,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46163,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46164,"numValue":6.39,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4616... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||
fireprotdb:6500 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,500 | train | mutant | 6,202 | 117 | 6,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105E | V105E | 1 | 1 | 0 | 0 | 105 | V | E | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,160 | ProTherm | 3.9 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:V23E | null | null | 5 | 4.4 | null | null | null | 1 | 5 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":3.9,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48182,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48183,"numValue":4.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48184,"numValue":5.0,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48185,"numValue":1.0,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6501 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,501 | train | mutant | 6,202 | 117 | 6,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105E | V105E | 1 | 1 | 0 | 0 | 105 | V | E | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,161 | ProTherm | 5 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:V23E | null | null | 6.7 | 5.1 | null | null | null | 1.2 | 5.7 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48187,"numValue":6.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48188,"numValue":5.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48189,"numValue":5.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48190,"numValue":1.2,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6502 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,502 | train | mutant | 6,202 | 117 | 6,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105E | V105E | 1 | 1 | 0 | 0 | 105 | V | E | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,162 | ProTherm | 6 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:V23E | null | null | 5.7 | 6 | null | null | null | 1 | 5.6 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48192,"numValue":5.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48193,"numValue":6.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48194,"numValue":5.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48195,"numValue":1.0,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6503 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,503 | train | mutant | 6,202 | 117 | 6,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105E | V105E | 1 | 1 | 0 | 0 | 105 | V | E | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,163 | ProTherm | 7.9 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:V23E | null | null | 4.4 | 7.5 | null | null | null | 0.7 | 5.9 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":7.9,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48197,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48198,"numValue":7.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48199,"numValue":5.9,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48200,"numValue":0.7,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6504 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,504 | train | mutant | 6,202 | 117 | 6,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105E | V105E | 1 | 1 | 0 | 0 | 105 | V | E | 6 | CONSERVATION | 1STN | 140 | null | 105 | A | E | true | false | 0.537484 | 12.74 | 13,164 | ProTherm | 9.1 | Fluorescence | GdnHCl | HEPES | 10 mM | 20 | NaCl | 100 mM | 1STN_A:V23E | null | null | 0 | 7.5 | null | null | null | 0.7 | 6 | null | null | null | null | null | null | null | Unknown | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 840 | ARTICLE | Charges in the hydrophobic interior of proteins. | 2,010 | 10.1073/pnas.1004213107 | 20798341 | Proc Natl Acad Sci U S A;107;16096-100 | 5 | Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D | [{"numValue":9.1,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF... | [{"datasets":[],"id":48202,"numValue":0.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48203,"numValue":7.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48204,"numValue":6.0,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48205,"numValue":0.7,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6506 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,506 | train | mutant | 7,220 | 117 | 7,875 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|L119A | V105F|L119A | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|119 | A | E|T | true | true | 6.987289 | 12.391875 | 15,529 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:L37A | null | null | null | 3.17 | null | null | null | null | 0.73 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57001,"numValue":3.17,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57002,"numValue":0.73,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57003,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7889,"numValue":9.0,"position":119,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6507 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,507 | train | mutant | 7,221 | 117 | 7,876 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|E157V | V105F|E157V | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|157 | A | E | true | false | 3.667694 | 12.810555 | 15,530 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:E75V | null | null | null | 4.79 | null | null | null | null | 0.58 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57004,"numValue":4.79,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57005,"numValue":0.58,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57006,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7927,"numValue":8.0,"position":157,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6508 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,508 | train | mutant | 7,222 | 117 | 7,877 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|G161S | V105F|G161S | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|161 | A | E|S | true | false | 9.747139 | 12.81125 | 15,531 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:G79S | null | null | null | 4.75 | null | null | null | null | 0.59 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57007,"numValue":4.75,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57008,"numValue":0.59,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57009,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7931,"numValue":6.0,"position":161,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6509 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,509 | train | mutant | 7,235 | 117 | 7,890 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|T115S | V105F|T115S | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|115 | A | E | true | false | 18.686926 | 12.672143 | 15,545 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:T33S | null | null | null | 2.72 | null | null | null | null | 1.03 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57049,"numValue":2.72,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57050,"numValue":1.03,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57051,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7885,"numValue":7.0,"position":115,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6510 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,510 | train | mutant | 7,236 | 117 | 7,891 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|A151T | V105F|A151T | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|151 | A | E|L | true | false | 12.862065 | 14.283 | 15,546 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:A69T | null | null | null | 4 | null | null | null | null | 1.17 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57052,"numValue":4.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57053,"numValue":1.17,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57054,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7921,"numValue":6.0,"position":151,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6511 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,511 | train | mutant | 7,237 | 117 | 7,892 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|A172S | V105F|A172S | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|172 | A | E | true | false | 0.268742 | 10.278 | 15,547 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:A90S | null | null | null | 3.31 | null | null | null | null | 1.06 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57055,"numValue":3.31,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57056,"numValue":1.06,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57057,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7942,"numValue":8.0,"position":172,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6512 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,512 | train | mutant | 7,252 | 117 | 7,907 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|I154V | V105F|I154V | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|154 | A | E | true | false | 6.971821 | 11.65125 | 15,562 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:I72V | null | null | null | 2.9 | null | null | null | null | 0.95 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57100,"numValue":2.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57101,"numValue":0.95,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57102,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6513 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,513 | train | mutant | 7,253 | 117 | 7,908 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|Y167A | V105F|Y167A | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|167 | A | E|T | true | true | 79.042329 | 15.436667 | 15,563 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:Y85A | null | null | null | 2.51 | null | null | null | null | 0.86 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57103,"numValue":2.51,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57104,"numValue":0.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57105,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7937,"numValue":9.0,"position":167,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6514 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,514 | train | mutant | 7,254 | 117 | 7,909 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|I174V | V105F|I174V | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|174 | A | E | true | false | 0.73904 | 11.021875 | 15,564 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:I92V | null | null | null | 2.01 | null | null | null | null | 0.96 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57106,"numValue":2.01,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57107,"numValue":0.96,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57108,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7944,"numValue":8.0,"position":174,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6515 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,515 | train | mutant | 7,255 | 117 | 7,910 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105F|Y195A | V105F|Y195A | 2 | 2 | 0 | 0 | 105 | V | F | 6 | CONSERVATION | 1STN | 140 | null | 105|195 | A | E|L | true | true | 84.763165 | 23.2675 | 15,565 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23F 1STN_A:Y113A | null | null | null | 1.89 | null | null | null | null | 0.91 | null | null | null | null | null | null | null | yes | DDG|M|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 842 | ARTICLE | Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. | 1,993 | 10.1021/bi00089a032 | 8399139 | Biochemistry;32;10131-9 | 2 | Shortle D|Green S M | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":57109,"numValue":1.89,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":57110,"numValue":0.91,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":57111,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7965,"numValue":9.0,"position":195,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:6517 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,517 | train | mutant | 7,997 | 117 | 8,724 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|V148I | V105I|L107I|V148I | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,149 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:V66I | null | null | 2.5 | 2.9 | null | null | null | 0.43 | 5.68 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63149,"numValue":2.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63150,"numValue":2.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63151,"numValue":5.68,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63152,"numValue":0.43,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6519 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,519 | train | mutant | 7,999 | 117 | 8,726 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148I | V105I|L107V|V148I | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,151 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66I | null | null | 2.7 | 2.7 | null | null | null | 0.46 | 5.81 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63159,"numValue":2.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63160,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63161,"numValue":5.81,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63162,"numValue":0.46,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6520 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,520 | train | mutant | 8,000 | 117 | 8,727 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148L | V105I|L107V|V148L | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,152 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66L | null | null | 3.3 | 2.1 | null | null | null | 0.6 | 5.49 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63164,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63165,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63166,"numValue":5.49,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63167,"numValue":0.6,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6521 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,521 | train | mutant | 8,001 | 117 | 8,728 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|V148L | V105L|L107V|V148L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,153 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:V66L | null | null | 3.4 | 2 | null | null | null | 0.56 | 6.14 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63169,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63170,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63171,"numValue":6.14,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63172,"numValue":0.56,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6523 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,523 | train | mutant | 8,003 | 117 | 8,730 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148I | V105L|L107I|V148I | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,155 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66I | null | null | 2.3 | 3.1 | null | null | null | 0.4 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63179,"numValue":2.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63180,"numValue":3.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63181,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63182,"numValue":0.4,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6524 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,524 | train | mutant | 8,004 | 117 | 8,731 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148L | V105L|L107I|V148L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148 | A | E|H | true | false | 1.077795 | 12.489524 | 17,156 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66L | null | null | 3 | 2.4 | null | null | null | 0.51 | 5.81 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63184,"numValue":3.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63185,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63186,"numValue":5.81,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63187,"numValue":0.51,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6525 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,525 | train | mutant | 8,005 | 117 | 8,732 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|I154V | V105I|L107I|I154V | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,157 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:I72V | null | null | 2.6 | 2.8 | null | null | null | 0.38 | 6.86 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63189,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63190,"numValue":2.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63191,"numValue":6.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63192,"numValue":0.38,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6526 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,526 | train | mutant | 8,006 | 117 | 8,733 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|I154L | V105I|L107I|I154L | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,158 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:I72L | null | null | 3.7 | 1.7 | null | null | null | 0.6 | 6.2 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63194,"numValue":3.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63195,"numValue":1.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63196,"numValue":6.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63197,"numValue":0.6,"references":[],"str... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6527 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,527 | train | mutant | 8,007 | 117 | 8,734 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|I154V | V105I|L107V|I154V | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,159 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:I72V | null | null | 3.1 | 2.3 | null | null | null | 0.44 | 7.05 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63199,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63200,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63201,"numValue":7.05,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63202,"numValue":0.44,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6529 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,529 | train | mutant | 8,009 | 117 | 8,736 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|I154V | V105L|L107V|I154V | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,161 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:I72V | null | null | 2.6 | 2.8 | null | null | null | 0.35 | 7.51 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63209,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63210,"numValue":2.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63211,"numValue":7.51,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63212,"numValue":0.35,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6530 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,530 | train | mutant | 8,010 | 117 | 8,737 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|I154L | V105L|L107V|I154L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,162 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:I72L | null | null | 3.9 | 1.5 | null | null | null | 0.57 | 6.86 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63214,"numValue":3.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63215,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63216,"numValue":6.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63217,"numValue":0.57,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6531 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,531 | train | mutant | 8,011 | 117 | 8,738 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|I154V | V105L|L107I|I154V | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,163 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:I72V | null | null | 2.9 | 2.5 | null | null | null | 0.41 | 7.05 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63219,"numValue":2.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63220,"numValue":2.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63221,"numValue":7.05,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63222,"numValue":0.41,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6532 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,532 | train | mutant | 8,012 | 117 | 8,739 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|I154L | V105L|L107I|I154L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154 | A | E | true | false | 4.647881 | 11.6475 | 17,164 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:I72L | null | null | 4 | 1.4 | null | null | null | 0.6 | 6.79 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63224,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63225,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63226,"numValue":6.79,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63227,"numValue":0.6,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6533 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,533 | train | mutant | 8,029 | 117 | 8,756 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|V148I|I154L | V105I|V148I|I154L | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,181 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:V66I 1STN_A:I72L | null | null | 3.4 | 2 | null | null | null | 0.62 | 5.42 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63309,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63310,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63311,"numValue":5.42,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63312,"numValue":0.62,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6534 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,534 | train | mutant | 8,030 | 117 | 8,757 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|V148I|I154V | V105I|V148I|I154V | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,182 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:V66I 1STN_A:I72V | null | null | 3.8 | 1.6 | null | null | null | 0.63 | 6.07 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63314,"numValue":3.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63315,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63316,"numValue":6.07,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63317,"numValue":0.63,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6536 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,536 | train | mutant | 8,032 | 117 | 8,759 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|V148L|I154V | V105I|V148L|I154V | 3 | 3 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,184 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:V66L 1STN_A:I72V | null | null | 4.5 | 0.9 | null | null | null | 0.76 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63324,"numValue":4.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63325,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63326,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63327,"numValue":0.76,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6537 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,537 | train | mutant | 8,033 | 117 | 8,760 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|V148I|I154L | V105L|V148I|I154L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,185 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:V66I 1STN_A:I72L | null | null | 3.4 | 2 | null | null | null | 0.58 | 5.94 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63329,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63330,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63331,"numValue":5.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63332,"numValue":0.58,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6538 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,538 | train | mutant | 8,034 | 117 | 8,761 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|V148I|I154V | V105L|V148I|I154V | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,186 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:V66I 1STN_A:I72V | null | null | 3.8 | 1.6 | null | null | null | 0.57 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63334,"numValue":3.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63335,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63336,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63337,"numValue":0.57,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6539 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,539 | train | mutant | 8,035 | 117 | 8,762 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|V148L|I154L | V105L|V148L|I154L | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,187 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:V66L 1STN_A:I72L | null | null | 4.1 | 1.3 | null | null | null | 0.65 | 6.27 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63339,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63340,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63341,"numValue":6.27,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63342,"numValue":0.65,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6540 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,540 | train | mutant | 8,036 | 117 | 8,763 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|V148L|I154V | V105L|V148L|I154V | 3 | 3 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|148|154 | A | E|H | true | false | 5.546514 | 12.130357 | 17,188 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:V66L 1STN_A:I72V | null | null | 4.1 | 1.3 | null | null | null | 0.64 | 6.46 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63344,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63345,"numValue":1.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63346,"numValue":6.46,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63347,"numValue":0.64,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6541 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,541 | train | mutant | 8,061 | 117 | 8,788 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|V148I|I154V | V105I|L107I|V148I|I154V | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,213 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:V66I 1STN_A:I72V | null | null | 2.2 | 3.2 | null | null | null | 0.35 | 6.14 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63469,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63470,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63471,"numValue":6.14,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63472,"numValue":0.35,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6542 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,542 | train | mutant | 8,062 | 117 | 8,789 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|V148I|I154L | V105I|L107I|V148I|I154L | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,214 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:V66I 1STN_A:I72L | null | null | 2.2 | 3.2 | null | null | null | 0.4 | 5.55 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63474,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63475,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63476,"numValue":5.55,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63477,"numValue":0.4,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6543 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,543 | train | mutant | 8,063 | 117 | 8,790 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|V148L|I154L | V105I|L107I|V148L|I154L | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,215 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:V66L 1STN_A:I72L | null | null | 2.7 | 2.7 | null | null | null | 0.47 | 5.75 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63479,"numValue":2.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63480,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63481,"numValue":5.75,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63482,"numValue":0.47,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6544 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,544 | train | mutant | 8,064 | 117 | 8,791 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107I|V148L|I154V | V105I|L107I|V148L|I154V | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,216 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25I 1STN_A:V66L 1STN_A:I72V | null | null | 2.8 | 2.6 | null | null | null | 0.48 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63484,"numValue":2.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63485,"numValue":2.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63486,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63487,"numValue":0.48,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6545 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,545 | train | mutant | 8,065 | 117 | 8,792 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148I|I154V | V105I|L107V|V148I|I154V | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,217 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66I 1STN_A:I72V | null | null | 2.4 | 3 | null | null | null | 0.37 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63489,"numValue":2.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63490,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63491,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63492,"numValue":0.37,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6546 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,546 | train | mutant | 8,066 | 117 | 8,793 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148I|I154L | V105I|L107V|V148I|I154L | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,218 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66I 1STN_A:I72L | null | null | 2.6 | 2.8 | null | null | null | 0.45 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63494,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63495,"numValue":2.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63496,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63497,"numValue":0.45,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6547 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,547 | train | mutant | 8,067 | 117 | 8,794 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148L|I154L | V105I|L107V|V148L|I154L | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,219 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66L 1STN_A:I72L | null | null | 2.9 | 2.5 | null | null | null | 0.49 | 5.94 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63499,"numValue":2.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63500,"numValue":2.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63501,"numValue":5.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63502,"numValue":0.49,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6548 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,548 | train | mutant | 8,068 | 117 | 8,795 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148L|I154V | V105I|L107V|V148L|I154V | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,220 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66L 1STN_A:I72V | null | null | 3.3 | 2.1 | null | null | null | 0.52 | 6.33 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63504,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63505,"numValue":2.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63506,"numValue":6.33,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63507,"numValue":0.52,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6549 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,549 | train | mutant | 8,069 | 117 | 8,796 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148I|I154V | V105L|L107I|V148I|I154V | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,221 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66I 1STN_A:I72V | null | null | 2 | 3.4 | null | null | null | 0.32 | 6.4 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63509,"numValue":2.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63510,"numValue":3.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63511,"numValue":6.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63512,"numValue":0.32,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6550 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,550 | train | mutant | 8,070 | 117 | 8,797 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148I|I154L | V105L|L107I|V148I|I154L | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,222 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66I 1STN_A:I72L | null | null | 2.2 | 3.2 | null | null | null | 0.37 | 5.88 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63514,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63515,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63516,"numValue":5.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63517,"numValue":0.37,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6551 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,551 | train | mutant | 8,071 | 117 | 8,798 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148L|I154L | V105L|L107I|V148L|I154L | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,223 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66L 1STN_A:I72L | null | null | 3 | 2.4 | null | null | null | 0.48 | 6.27 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63519,"numValue":3.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63520,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63521,"numValue":6.27,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63522,"numValue":0.48,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6552 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,552 | train | mutant | 8,072 | 117 | 8,799 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107I|V148L|I154V | V105L|L107I|V148L|I154V | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,224 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25I 1STN_A:V66L 1STN_A:I72V | null | null | 2.8 | 2.6 | null | null | null | 0.41 | 6.73 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63524,"numValue":2.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63525,"numValue":2.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63526,"numValue":6.73,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63527,"numValue":0.41,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6553 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,553 | train | mutant | 8,073 | 117 | 8,800 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|V148I|I154V | V105L|L107V|V148I|I154V | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,225 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:V66I 1STN_A:I72V | null | null | 2 | 3.4 | null | null | null | 0.28 | 7.05 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63529,"numValue":2.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63530,"numValue":3.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63531,"numValue":7.05,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63532,"numValue":0.28,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6554 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,554 | train | mutant | 8,074 | 117 | 8,801 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|V148I|I154L | V105L|L107V|V148I|I154L | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,226 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:V66I 1STN_A:I72L | null | null | 2.6 | 2.8 | null | null | null | 0.41 | 6.2 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63534,"numValue":2.6,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63535,"numValue":2.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63536,"numValue":6.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63537,"numValue":0.41,"references":[],"st... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6555 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,555 | train | mutant | 8,075 | 117 | 8,802 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|V148L|I154L | V105L|L107V|V148L|I154L | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,227 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:V66L 1STN_A:I72L | null | null | 3.4 | 2 | null | null | null | 0.52 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63539,"numValue":3.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63540,"numValue":2.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63541,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63542,"numValue":0.52,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6556 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,556 | train | mutant | 8,076 | 117 | 8,803 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105L|L107V|V148L|I154V | V105L|L107V|V148L|I154V | 4 | 4 | 0 | 0 | 105 | V | L | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154 | A | E|H | true | false | 4.159886 | 12.007768 | 17,228 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23L 1STN_A:L25V 1STN_A:V66L 1STN_A:I72V | null | null | 2.9 | 2.5 | null | null | null | 0.42 | 6.79 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 984 | ARTICLE | Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease. | 2,001 | 10.1021/bi011269d | 11705393 | Biochemistry;40;14012-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63544,"numValue":2.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63545,"numValue":2.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63546,"numValue":6.79,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63547,"numValue":0.42,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6557 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,557 | train | mutant | 8,093 | 117 | 8,820 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|I154V|I174V | V105I|L107V|I154V|I174V | 4 | 4 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|154|174 | A | E | true | false | 3.72106 | 11.061563 | 17,245 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:I72V 1STN_A:I92V | null | null | 3 | 2.4 | null | null | null | 0.41 | 7.18 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 985 | ARTICLE | Packing is a key selection factor in the evolution of protein hydrophobic cores. | 2,001 | 10.1021/bi011776v | 11735410 | Biochemistry;40;15280-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63629,"numValue":3.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63630,"numValue":2.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63631,"numValue":7.18,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63632,"numValue":0.41,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang... | |||||||||||
fireprotdb:6558 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 6,558 | train | mutant | 8,094 | 117 | 8,821 | 231 | 231 | 11 | Thermonuclease | Staphylococcus aureus | 1 | 11 | Thermonuclease | Staphylococcus aureus | 1 | P00644 | IPR035437|IPR016071|IPR002071 | 3.1.31.1 | V105I|L107V|V148L|I154V|I174V | V105I|L107V|V148L|I154V|I174V | 5 | 5 | 0 | 0 | 105 | V | I | 6 | CONSERVATION | 1STN | 140 | null | 105|107|148|154|174 | A | E|H | true | false | 3.516028 | 11.466964 | 17,246 | ProTherm | 7 | Fluorescence | GdnHCl | Sodium phosphate | 25 mM | 20 | NaCl | 100 mM | 1STN_A:V23I 1STN_A:L25V 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V | null | null | 3.5 | 1.9 | null | null | null | 0.53 | 6.53 | null | null | null | null | null | null | null | yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 985 | ARTICLE | Packing is a key selection factor in the evolution of protein hydrophobic cores. | 2,001 | 10.1021/bi011776v | 11735410 | Biochemistry;40;15280-9 | 2 | Chen J|Stites W E | [{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",... | [{"datasets":[],"id":63634,"numValue":3.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63635,"numValue":1.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63636,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63637,"numValue":0.53,"references":[],"s... | [{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang... |
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