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string
dataset_id
string
source_dataset
string
source_file
string
source_table
string
source_sha
string
row_index
int64
split
string
subject_type
string
entry_id
int64
sequence_id
int64
target_sequence_id
int64
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int64
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string
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string
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string
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string
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string
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string
conservation
float64
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string
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string
afdb_ids
string
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string
structure_methods
string
structure_resolution_min
float64
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string
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string
residue_secondary_structures
string
residue_in_pocket_any
bool
residue_in_tunnel_any
bool
residue_asa_mean
float64
residue_bfactor_mean
float64
experiment_id
int64
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string
ph
float64
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string
method
string
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string
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string
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float64
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string
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string
tm
float64
dtm
float64
dg
float64
dg_text
string
ddg
float64
dh
float64
dcp
float64
dhvh
float64
cm
float64
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float64
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float64
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float64
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float64
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string
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float64
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float64
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float64
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float64
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
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string
fireprotdb:6559
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,559
train
mutant
8,095
117
8,822
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|V148L|I154V|I174V
V105I|V148L|I154V|I174V
4
4
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|148|154|174
A
E|H
true
false
4.395035
11.423705
17,247
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V
null
null
4.8
0.6
null
null
null
0.74
6.53
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
985
ARTICLE
Packing is a key selection factor in the evolution of protein hydrophobic cores.
2,001
10.1021/bi011776v
11735410
Biochemistry;40;15280-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63639,"numValue":4.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63640,"numValue":0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63641,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63642,"numValue":0.74,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6560
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,560
train
mutant
8,096
117
8,823
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|L107V|I154V|I174V|V181L
V105I|L107V|I154V|I174V|V181L
5
5
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|107|154|174|181
A
E|H
true
false
3.084345
10.181821
17,248
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:L25V 1STN_A:I72V 1STN_A:I92V 1STN_A:V99L
null
null
2.4
3
null
null
null
0.33
7.25
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
985
ARTICLE
Packing is a key selection factor in the evolution of protein hydrophobic cores.
2,001
10.1021/bi011776v
11735410
Biochemistry;40;15280-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63644,"numValue":2.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63645,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63646,"numValue":7.25,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63647,"numValue":0.33,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6561
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,561
train
mutant
8,097
117
8,824
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|L107V|I154V|I174V|V181I
V105I|L107V|I154V|I174V|V181I
5
5
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|107|154|174|181
A
E|H
true
false
3.084345
10.181821
17,249
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:L25V 1STN_A:I72V 1STN_A:I92V 1STN_A:V99I
null
null
2.7
2.7
null
null
null
0.39
7.05
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
985
ARTICLE
Packing is a key selection factor in the evolution of protein hydrophobic cores.
2,001
10.1021/bi011776v
11735410
Biochemistry;40;15280-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63649,"numValue":2.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63650,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63651,"numValue":7.05,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63652,"numValue":0.39,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6562
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,562
train
mutant
8,098
117
8,825
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|L107I|V148L|I154V|I174V
V105I|L107I|V148L|I154V|I174V
5
5
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|107|148|154|174
A
E|H
true
false
3.516028
11.466964
17,250
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:L25I 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V
null
null
3.1
2.3
null
null
null
0.47
6.53
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
985
ARTICLE
Packing is a key selection factor in the evolution of protein hydrophobic cores.
2,001
10.1021/bi011776v
11735410
Biochemistry;40;15280-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63654,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63655,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63656,"numValue":6.53,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63657,"numValue":0.47,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang...
fireprotdb:6563
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,563
train
mutant
8,099
117
8,826
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|L107V|V148L|I154V|I174V
V105L|L107V|V148L|I154V|I174V
5
5
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|107|148|154|174
A
E|H
true
false
3.516028
11.466964
17,251
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:L25V 1STN_A:V66L 1STN_A:I72V 1STN_A:I92V
null
null
3.2
2.2
null
null
null
0.45
7.12
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
985
ARTICLE
Packing is a key selection factor in the evolution of protein hydrophobic cores.
2,001
10.1021/bi011776v
11735410
Biochemistry;40;15280-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63659,"numValue":3.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63660,"numValue":2.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63661,"numValue":7.12,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63662,"numValue":0.45,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRang...
fireprotdb:6564
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,564
train
mutant
8,100
117
8,827
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|L107I
V105I|L107I
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|107
A
E
true
false
0.268742
12.19
17,252
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:L25I
null
null
3.7
1.7
null
null
null
0.6
0.93
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63664,"numValue":3.7,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63665,"numValue":1.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63666,"numValue":0.93,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63667,"numValue":0.6,"references":[],"st...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6565
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,565
train
mutant
8,101
117
8,828
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|L107V
V105I|L107V
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|107
A
E
true
false
0.268742
12.19
17,253
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:L25V
null
null
4
1.4
null
null
null
0.63
0.95
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63669,"numValue":4.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63670,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63671,"numValue":0.95,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63672,"numValue":0.63,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6566
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,566
train
mutant
8,102
117
8,829
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|L107I
V105L|L107I
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|107
A
E
true
false
0.268742
12.19
17,254
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:L25I
null
null
3.9
1.5
null
null
null
0.6
0.97
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63674,"numValue":3.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63675,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63676,"numValue":0.97,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63677,"numValue":0.6,"references":[],"st...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6567
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,567
train
mutant
8,103
117
8,830
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|L107V
V105L|L107V
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|107
A
E
true
false
0.268742
12.19
17,255
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:L25V
null
null
3.6
1.8
null
null
null
0.53
1.01
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6568
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,568
train
mutant
8,112
117
8,839
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|V148I
V105I|V148I
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|148
A
E|H
true
false
1.616692
12.914286
17,264
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:V66I
null
null
3.9
1.5
null
null
null
0.75
0.78
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6569
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,569
train
mutant
8,113
117
8,840
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|V148L
V105I|V148L
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|148
A
E|H
true
false
1.616692
12.914286
17,265
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:V66L
null
null
4.4
1
null
null
null
0.89
0.74
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63729,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63730,"numValue":1.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63731,"numValue":0.74,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63732,"numValue":0.89,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6570
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,570
train
mutant
8,114
117
8,841
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|V148I
V105L|V148I
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|148
A
E|H
true
false
1.616692
12.914286
17,266
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:V66I
null
null
3.9
1.5
null
null
null
0.67
0.86
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63734,"numValue":3.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63735,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63736,"numValue":0.86,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63737,"numValue":0.67,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6571
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,571
train
mutant
8,115
117
8,842
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|V148L
V105L|V148L
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|148
A
E|H
true
false
1.616692
12.914286
17,267
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:V66L
null
null
4.3
1.1
null
null
null
0.78
0.83
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63739,"numValue":4.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63740,"numValue":1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63741,"numValue":0.83,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63742,"numValue":0.78,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6572
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,572
train
mutant
8,120
117
8,847
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|I154L
V105I|I154L
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|154
A
E
true
false
6.971821
11.65125
17,272
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:I72L
null
null
4.9
0.5
null
null
null
0.8
0.91
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63764,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63765,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63766,"numValue":0.91,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63767,"numValue":0.8,"references":[],"st...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6573
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,573
train
mutant
8,121
117
8,848
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105I|I154V
V105I|I154V
2
2
0
0
105
V
I
6
CONSERVATION
1STN
140
null
105|154
A
E
true
false
6.971821
11.65125
17,273
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23I 1STN_A:I72V
null
null
4.3
1.1
null
null
null
0.64
1.01
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63769,"numValue":4.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63770,"numValue":1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63771,"numValue":1.01,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63772,"numValue":0.64,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6574
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,574
train
mutant
8,122
117
8,849
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|I154L
V105L|I154L
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|154
A
E
true
false
6.971821
11.65125
17,274
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:I72L
null
null
5
0.4
null
null
null
0.79
0.95
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63774,"numValue":5.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63775,"numValue":0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63776,"numValue":0.95,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63777,"numValue":0.79,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6575
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,575
train
mutant
8,123
117
8,850
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
V105L|I154V
V105L|I154V
2
2
0
0
105
V
L
6
CONSERVATION
1STN
140
null
105|154
A
E
true
false
6.971821
11.65125
17,275
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:V23L 1STN_A:I72V
null
null
4.3
1.1
null
null
null
0.62
1.04
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63779,"numValue":4.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63780,"numValue":1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63781,"numValue":1.04,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63782,"numValue":0.62,"references":[],"s...
[{"id":7875,"numValue":6.0,"position":105,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6576
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,576
train
mutant
1,603
117
1,803
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K106G
K106G
1
1
0
0
106
K
G
5
CONSERVATION
1STN
140
null
106
A
E
false
false
73.299275
23.723334
3,006
ProTherm
7
DSC
Thermal
Sodium phosphate
20 mM
null
NaCl
100 mM
1STN_A:K24G
47.9
-6.3
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
Saraboji_S2204.csv|STRUM_Q3421.csv|AUTOMUTE_S1749.csv|Saraboji_S1791.csv|AUTOMUTE_S1962.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
268
ARTICLE
Energetics of denaturation and m values of staphylococcal nuclease mutants.
1,995
10.1021/bi00006a025
7849061
Biochemistry;34;2034-41
2
Privalov P L|Carra J H
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"IO...
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fireprotdb:6577
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,577
train
mutant
1,603
117
1,803
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K106G
K106G
1
1
0
0
106
K
G
5
CONSERVATION
1STN
140
null
106
A
E
false
false
73.299275
23.723334
12,861
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K24G
null
null
4.4
1.2
null
null
null
0.51
1.23
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
827
ARTICLE
Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.
1,996
10.1021/bi960171+
8639591
Biochemistry;35;6443-9
3
Shortle D|Garcia-Moreno B|Meeker A K
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fireprotdb:6578
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,578
train
mutant
5,987
117
6,557
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K106A
K106A
1
1
0
0
106
K
A
5
CONSERVATION
1STN
140
null
106
A
E
false
false
73.299275
23.723334
12,860
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K24A
null
null
5.4
0.2
null
null
null
0.73
1.06
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
827
ARTICLE
Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.
1,996
10.1021/bi960171+
8639591
Biochemistry;35;6443-9
3
Shortle D|Garcia-Moreno B|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6579
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,579
train
mutant
6,245
117
6,840
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K106F
K106F
1
1
0
0
106
K
F
5
CONSERVATION
1STN
140
null
106
A
E
false
false
73.299275
23.723334
13,334
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K24F
null
null
4.9
0.6
null
null
null
0.8
0.93
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
845
ARTICLE
Stability effects of increasing the hydrophobicity of solvent-exposed side chains in staphylococcal nuclease.
1,998
10.1021/bi9725069
9578580
Biochemistry;37;6939-48
4
Stites W E|Schwehm J M|Kristyanne E S|Biggers C C
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[{"id":7876,"numValue":5.0,"position":106,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6581
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,581
train
mutant
107
117
118
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107A
L107A
1
1
0
0
107
L
A
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
219
ProTherm
5
DSC
Thermal
phosphate
0.05 M
null
NaCl
0.1 M
1STN_A:L25A
31.2
-15.8
null
null
63
2.5
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|DCP|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
16
ARTICLE
Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry.
1,993
10.1002/pro.5560020408
8518730
Protein Sci;2;567-76
3
Tanaka A|Sturtevant J M|Flanagan J
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fireprotdb:6582
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,582
train
mutant
107
117
118
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107A
L107A
1
1
0
0
107
L
A
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
7,603
ProTherm
7
DSC
Thermal
phosphate
0.05 M
51.4
NaCl
0.1 M
1STN_A:L25A
null
null
null
2.6
null
2.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv|khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
16
ARTICLE
Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry.
1,993
10.1002/pro.5560020408
8518730
Protein Sci;2;567-76
3
Tanaka A|Sturtevant J M|Flanagan J
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[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6583
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,583
train
mutant
107
117
118
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107A
L107A
1
1
0
0
107
L
A
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
7,790
ProTherm
5
DSC
Thermal
phosphate
0.05 M
47
NaCl
0.1 M
1STN_A:L25A
null
null
null
2.8
null
2.5
null
null
null
null
null
null
null
null
null
null
yes
DCP|DDG|REVERSIBILITY
capriotti_S1615_map.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
16
ARTICLE
Thermal unfolding of staphylococcal nuclease and several mutant forms thereof studied by differential scanning calorimetry.
1,993
10.1002/pro.5560020408
8518730
Protein Sci;2;567-76
3
Tanaka A|Sturtevant J M|Flanagan J
[{"numValue":5.0,"strValue":null,"type":"PH"},{"numValue":47.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"0.05 M","type":"BUFFER...
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[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6584
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,584
train
mutant
107
117
118
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107A
L107A
1
1
0
0
107
L
A
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,407
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25A
null
null
2.78
2.7
null
null
null
0.3
1.12
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":49383,"numValue":2.78,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49384,"numValue":2.7,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49385,"numValue":1.12,"references":[],"strValue":n...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6585
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,585
train
mutant
5,915
117
6,485
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I
L107I
1
1
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
12,759
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I
null
null
3.7
1.7
null
null
null
0.52
7.05
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
821
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines.
2,001
10.1021/bi011267t
11705391
Biochemistry;40;13998-4003
6
Chen J|Stites W E|Spencer D S|Byrne M P|Holder J B|Bennett A F
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6586
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,586
train
mutant
5,916
117
6,486
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107V
L107V
1
1
0
0
107
L
V
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
12,760
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V
null
null
3.6
1.8
null
null
null
0.53
6.89
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
821
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by exchange of valines, isoleucines, and leucines.
2,001
10.1021/bi011267t
11705391
Biochemistry;40;13998-4003
6
Chen J|Stites W E|Spencer D S|Byrne M P|Holder J B|Bennett A F
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":46327,"numValue":3.6,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":46328,"numValue":1.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46329,"numValue":6.89,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46330,"numValue":0.53,...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6587
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,587
train
mutant
6,203
117
6,797
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107E
L107E
1
1
0
0
107
L
E
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,165
ProTherm
3.9
Fluorescence
GdnHCl
HEPES
10 mM
20
NaCl
100 mM
1STN_A:L25E
null
null
3.5
5.9
null
null
null
0.7
5
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
840
ARTICLE
Charges in the hydrophobic interior of proteins.
2,010
10.1073/pnas.1004213107
20798341
Proc Natl Acad Sci U S A;107;16096-100
5
Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D
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fireprotdb:6588
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,588
train
mutant
6,203
117
6,797
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107E
L107E
1
1
0
0
107
L
E
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,166
ProTherm
5
Fluorescence
GdnHCl
HEPES
10 mM
20
NaCl
100 mM
1STN_A:L25E
null
null
5.4
6.4
null
null
null
0.9
5.8
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
840
ARTICLE
Charges in the hydrophobic interior of proteins.
2,010
10.1073/pnas.1004213107
20798341
Proc Natl Acad Sci U S A;107;16096-100
5
Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D
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[{"datasets":[],"id":48212,"numValue":5.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48213,"numValue":6.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48214,"numValue":5.8,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48215,"numValue":0.9,"references":[],"str...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6589
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,589
train
mutant
6,203
117
6,797
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107E
L107E
1
1
0
0
107
L
E
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,167
ProTherm
6
Fluorescence
GdnHCl
HEPES
10 mM
20
NaCl
100 mM
1STN_A:L25E
null
null
4.1
7.6
null
null
null
0.8
5.5
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
840
ARTICLE
Charges in the hydrophobic interior of proteins.
2,010
10.1073/pnas.1004213107
20798341
Proc Natl Acad Sci U S A;107;16096-100
5
Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D
[{"numValue":6.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF...
[{"datasets":[],"id":48217,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48218,"numValue":7.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48219,"numValue":5.5,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48220,"numValue":0.8,"references":[],"str...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6590
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,590
train
mutant
6,203
117
6,797
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107E
L107E
1
1
0
0
107
L
E
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,168
ProTherm
8
Fluorescence
GdnHCl
HEPES
10 mM
20
NaCl
100 mM
1STN_A:L25E
null
null
2.1
9.8
null
null
null
0.5
4.3
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
840
ARTICLE
Charges in the hydrophobic interior of proteins.
2,010
10.1073/pnas.1004213107
20798341
Proc Natl Acad Sci U S A;107;16096-100
5
Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D
[{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF...
[{"datasets":[],"id":48222,"numValue":2.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48223,"numValue":9.8,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48224,"numValue":4.3,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48225,"numValue":0.5,"references":[],"str...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6591
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,591
train
mutant
6,203
117
6,797
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107E
L107E
1
1
0
0
107
L
E
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,169
ProTherm
9
Fluorescence
GdnHCl
HEPES
10 mM
20
NaCl
100 mM
1STN_A:L25E
null
null
2.1
9.5
null
null
null
0.5
4.4
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
840
ARTICLE
Charges in the hydrophobic interior of proteins.
2,010
10.1073/pnas.1004213107
20798341
Proc Natl Acad Sci U S A;107;16096-100
5
Isom Daniel G|Garc?a-Moreno E Bertrand|Casta?eda Carlos A|Cannon Brian R|Velu Priya D
[{"numValue":9.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"HEPES","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUF...
[{"datasets":[],"id":48227,"numValue":2.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":48228,"numValue":9.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":48229,"numValue":4.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":48230,"numValue":0.5,"references":[],"str...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6592
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,592
train
mutant
6,285
117
6,885
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107G
L107G
1
1
0
0
107
L
G
7
CONSERVATION
1STN
140
null
107
A
E
true
false
0
11.64
13,408
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25G
null
null
0.98
4.5
null
null
null
0.1
1.18
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":49388,"numValue":0.98,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49389,"numValue":4.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49390,"numValue":1.18,"references":[],"strValue":n...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6593
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,593
train
mutant
7,197
117
7,852
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107A|M108A
L107A|M108A
2
2
0
0
107
L
A
7
CONSERVATION
1STN
140
null
107|108
A
E
true
false
35.465714
17.290625
15,502
ProTherm
7
CD
GdnHCl
NaH2PO4
10 mM
20
NaCl
100 mM
1STN_A:L25A 1STN_A:M26A
null
null
null
4.4
null
null
null
null
1.2
null
null
null
null
null
null
null
Unknown
DDG|M|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
935
ARTICLE
Structural and energetic differences between insertions and substitutions in staphylococcal nuclease.
1,992
10.1002/prot.340130206
1620695
Proteins;13;132-40
2
Shortle D|Sondek J
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"NaH2PO4","type":"BUFFER"},{"numValue":null,"strValue":"10 mM","type":"BUFFER_CONC...
[{"datasets":[],"id":56918,"numValue":4.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":56919,"numValue":1.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":56920,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6594
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,594
train
mutant
8,037
117
8,764
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148I|I154L
L107I|V148I|I154L
3
3
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|148|154
A
E|H
true
false
5.367353
11.76369
17,189
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66I 1STN_A:I72L
null
null
2.4
3
null
null
null
0.38
6.33
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63349,"numValue":2.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63350,"numValue":3.0,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63351,"numValue":6.33,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63352,"numValue":0.38,"references":[],"s...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6595
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,595
train
mutant
8,038
117
8,765
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148I|I154V
L107I|V148I|I154V
3
3
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|148|154
A
E|H
true
false
5.367353
11.76369
17,190
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66I 1STN_A:I72V
null
null
2.2
3.2
null
null
null
0.32
6.99
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63354,"numValue":2.2,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63355,"numValue":3.2,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63356,"numValue":6.99,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63357,"numValue":0.32,"references":[],"s...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6596
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,596
train
mutant
8,039
117
8,766
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148L|I154L
L107I|V148L|I154L
3
3
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|148|154
A
E|H
true
false
5.367353
11.76369
17,191
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66L 1STN_A:I72L
null
null
3.1
2.3
null
null
null
0.49
6.2
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63359,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63360,"numValue":2.3,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63361,"numValue":6.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63362,"numValue":0.49,"references":[],"st...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7918,"numValue":8.0,"position":148,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRang...
fireprotdb:6597
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,597
train
mutant
8,040
117
8,767
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148L|I154V
L107I|V148L|I154V
3
3
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|148|154
A
E|H
true
false
5.367353
11.76369
17,192
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66L 1STN_A:I72V
null
null
3.2
2.2
null
null
null
0.51
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null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6598
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
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231
231
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Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
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ProTherm
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Fluorescence
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Sodium phosphate
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20
NaCl
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null
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null
null
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DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6599
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,599
train
mutant
8,042
117
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231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
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ProTherm
7
Fluorescence
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Sodium phosphate
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20
NaCl
100 mM
1STN_A:L25V 1STN_A:V66I 1STN_A:I72V
null
null
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null
null
null
0.32
7.12
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
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fireprotdb:6600
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,600
train
mutant
8,043
117
8,770
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
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ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:V66L 1STN_A:I72L
null
null
3.2
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null
null
null
0.51
6.33
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6601
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,601
train
mutant
8,044
117
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231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
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ProTherm
7
Fluorescence
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Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:V66L 1STN_A:I72V
null
null
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null
null
null
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null
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null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
984
ARTICLE
Higher-order packing interactions in triple and quadruple mutants of staphylococcal nuclease.
2,001
10.1021/bi011269d
11705393
Biochemistry;40;14012-9
2
Chen J|Stites W E
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fireprotdb:6602
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,602
train
mutant
8,116
117
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231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148I
L107I|V148I
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2
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0
107
L
I
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CONSERVATION
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140
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ProTherm
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Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66I
null
null
2.4
3
null
null
null
0.38
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null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
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fireprotdb:6603
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,603
train
mutant
8,117
117
8,844
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|V148L
L107I|V148L
2
2
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|148
A
E|H
true
false
1.34795
12.364286
17,269
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:V66L
null
null
3.5
1.9
null
null
null
0.6
0.88
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
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fireprotdb:6604
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,604
train
mutant
8,118
117
8,845
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107V|V148I
L107V|V148I
2
2
0
0
107
L
V
7
CONSERVATION
1STN
140
null
107|148
A
E|H
true
false
1.34795
12.364286
17,270
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:V66I
null
null
2.5
2.9
null
null
null
0.4
0.94
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
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fireprotdb:6605
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,605
train
mutant
8,119
117
8,846
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107V|V148L
L107V|V148L
2
2
0
0
107
L
V
7
CONSERVATION
1STN
140
null
107|148
A
E|H
true
false
1.34795
12.364286
17,271
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:V66L
null
null
3.6
1.8
null
null
null
0.6
0.89
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6607
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,607
train
mutant
8,125
117
8,852
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107I|I154V
L107I|I154V
2
2
0
0
107
L
I
7
CONSERVATION
1STN
140
null
107|154
A
E
true
false
6.703079
11.10125
17,277
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25I 1STN_A:I72V
null
null
2.4
3
null
null
null
0.32
1.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
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fireprotdb:6608
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,608
train
mutant
8,126
117
8,853
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107V|I154L
L107V|I154L
2
2
0
0
107
L
V
7
CONSERVATION
1STN
140
null
107|154
A
E
true
false
6.703079
11.10125
17,278
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:I72L
null
null
3.8
1.6
null
null
null
0.56
1.03
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63794,"numValue":3.8,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63795,"numValue":1.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63796,"numValue":1.03,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63797,"numValue":0.56,"references":[],"s...
[{"id":7877,"numValue":7.0,"position":107,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":7924,"numValue":8.0,"position":154,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6609
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,609
train
mutant
8,127
117
8,854
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
L107V|I154V
L107V|I154V
2
2
0
0
107
L
V
7
CONSERVATION
1STN
140
null
107|154
A
E
true
false
6.703079
11.10125
17,279
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:L25V 1STN_A:I72V
null
null
2.5
2.9
null
null
null
0.35
1.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
986
ARTICLE
Energetics of side chain packing in staphylococcal nuclease assessed by systematic double mutant cycles.
2,001
10.1021/bi011268l
11705392
Biochemistry;40;14004-11
2
Chen J|Stites W E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":63799,"numValue":2.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":63800,"numValue":2.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":63801,"numValue":1.09,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":63802,"numValue":0.35,"references":[],"s...
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fireprotdb:6610
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,610
train
mutant
4,694
117
5,232
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108G
M108G
1
1
0
0
108
M
G
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
11,076
ProTherm
5.6
Fluorescence
GdnHCl
Sodium acetate
50 mM
25
NaCl
100 mM
1STN_A:M26G
null
null
2.5
null
null
null
null
null
7.9
null
null
null
null
null
null
null
Unknown
DG|M|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
741
ARTICLE
A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease.
1,999
10.1038/12338
10467101
Nat Struct Biol;6;876-83
2
Wrabl J|Shortle D
[{"numValue":5.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","t...
[{"datasets":[],"id":38131,"numValue":2.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38132,"numValue":7.9,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38133,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6611
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,611
train
mutant
4,694
117
5,232
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108G
M108G
1
1
0
0
108
M
G
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
11,077
ProTherm
5.2
Fluorescence
GdnHCl
Sodium acetate
50 mM
25
NaCl
100 mM
1STN_A:M26G
null
null
3.1
null
null
null
null
null
7.4
null
null
null
null
null
null
null
Unknown
DG|M|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
741
ARTICLE
A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease.
1,999
10.1038/12338
10467101
Nat Struct Biol;6;876-83
2
Wrabl J|Shortle D
[{"numValue":5.2,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium acetate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","t...
[{"datasets":[],"id":38134,"numValue":3.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38135,"numValue":7.4,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":38136,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6613
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,613
train
mutant
4,694
117
5,232
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108G
M108G
1
1
0
0
108
M
G
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
13,543
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M26G
null
null
3.3
null
null
null
null
null
7.6
null
null
null
null
null
null
null
Unknown
DG|M|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
741
ARTICLE
A model of the changes in denatured state structure underlying m value effects in staphylococcal nuclease.
1,999
10.1038/12338
10467101
Nat Struct Biol;6;876-83
2
Wrabl J|Shortle D
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":50051,"numValue":3.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":50052,"numValue":7.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":50053,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6614
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,614
train
mutant
5,879
117
6,449
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108I
M108I
1
1
0
0
108
M
I
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
12,721
ProTherm
7
Fluorescence
GdnHCl
sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M26I
null
null
4.5
0.9
null
null
null
0.7
0.99
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
820
ARTICLE
Comparing the effect on protein stability of methionine oxidation versus mutagenesis: steps toward engineering oxidative resistance in proteins.
2,001
10.1093/protein/14.5.343
11438757
Protein Eng;14;343-7
4
Stites W E|Spencer D S|Kim Y H|Berry A H
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":46132,"numValue":4.5,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv"],"id":46133,"numValue":0.9,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46134,"numValue":0.99,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46135,"numValue":0.7,"...
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6615
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,615
train
mutant
5,882
117
6,452
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108L
M108L
1
1
0
0
108
M
L
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
12,724
ProTherm
7
Fluorescence
GdnHCl
sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M26L
null
null
4.9
0.5
null
null
null
0.8
0.93
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
820
ARTICLE
Comparing the effect on protein stability of methionine oxidation versus mutagenesis: steps toward engineering oxidative resistance in proteins.
2,001
10.1093/protein/14.5.343
11438757
Protein Eng;14;343-7
4
Stites W E|Spencer D S|Kim Y H|Berry A H
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":46147,"numValue":4.9,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S1262.csv","SAAFEC_S983.csv"],"id":46148,"numValue":0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46149,"numValue":0.93,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":4615...
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6616
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,616
train
mutant
6,315
117
6,915
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M108A
M108A
1
1
0
0
108
M
A
3
CONSERVATION
1STN
140
null
108
A
E
true
false
70.931428
22.94125
13,449
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M26A
null
null
3.98
1.5
null
null
null
0.5
1.07
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":49592,"numValue":3.98,"references":[],"strValue":null,"type":"DG"},{"datasets":["guerios_625_map.csv","potapov_with_uniprot_mapping.csv","SAAFEC_S1262.csv"],"id":49593,"numValue":1.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49594,"numValue":1.07,"references":[],"strValue":n...
[{"id":7878,"numValue":3.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6618
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,618
train
mutant
1,230
117
1,380
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109F
Y109F
1
1
0
0
109
Y
F
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
2,488
ProTherm
7
Fluorescence
Thermal
Phosphate
25 mM
null
NaCl
100 mM
1STN_A:Y27F
51
-2
null
null
null
null
82
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
PoPMuSiC-2.0_S2648.csv|STRUM_Q3421.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
225
ARTICLE
Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation.
2,007
10.1016/j.bpc.2006.10.014
17134819
Biophys Chem;125;490-6
2
Byrne Michael P|Stites Wesley E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"...
[{"datasets":["PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":9162,"numValue":51.0,"references":[],"strValue":null,"type":"TM"},{"datasets":["PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":9163,"numValue":-2.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9164,"numValue":82.0,"references":[],"strV...
[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6619
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,619
train
mutant
1,230
117
1,380
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109F
Y109F
1
1
0
0
109
Y
F
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,280
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27F
null
null
5
0
null
null
null
0.77
1.1
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6620
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,620
train
mutant
1,230
117
1,380
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109F
Y109F
1
1
0
0
109
Y
F
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,496
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27F
null
null
5
0.6
null
null
null
0.74
1.01
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
853
ARTICLE
Energetic contribution of side chain hydrogen bonding to the stability of staphylococcal nuclease.
1,995
10.1021/bi00042a029
7577991
Biochemistry;34;13949-60
4
Stites W E|Byrne M P|Manuel R L|Lowe L G
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6621
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,621
train
mutant
6,225
117
6,819
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109A
Y109A
1
1
0
0
109
Y
A
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,277
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27A
null
null
2.2
2.8
null
null
null
0.29
1.07
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6622
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,622
train
mutant
6,225
117
6,819
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109A
Y109A
1
1
0
0
109
Y
A
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,457
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27A
null
null
1.28
4.2
null
null
null
0.1
1.1
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6623
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,623
train
mutant
6,226
117
6,820
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109C
Y109C
1
1
0
0
109
Y
C
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,278
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27C
null
null
2.1
2.9
null
null
null
0.41
1.02
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6624
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,624
train
mutant
6,227
117
6,821
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109E
Y109E
1
1
0
0
109
Y
E
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,279
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27E
null
null
0
5
null
null
null
null
null
null
null
null
null
null
null
null
yes
DG|DDG|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6625
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,625
train
mutant
6,228
117
6,822
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109H
Y109H
1
1
0
0
109
Y
H
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,281
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27H
null
null
3.4
1.6
null
null
null
0.48
1.19
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6626
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,626
train
mutant
6,229
117
6,823
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109I
Y109I
1
1
0
0
109
Y
I
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,282
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27I
null
null
2.5
2.5
null
null
null
0.49
0.81
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6627
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,627
train
mutant
6,230
117
6,824
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109K
Y109K
1
1
0
0
109
Y
K
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,283
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27K
null
null
1.1
3.9
null
null
null
0.22
1.07
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6628
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,628
train
mutant
6,231
117
6,825
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109L
Y109L
1
1
0
0
109
Y
L
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,284
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27L
null
null
3.5
1.5
null
null
null
0.57
1.07
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6630
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,630
train
mutant
6,232
117
6,826
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109M
Y109M
1
1
0
0
109
Y
M
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,285
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27M
null
null
3
2
null
null
null
0.52
0.98
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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fireprotdb:6631
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,631
train
mutant
6,233
117
6,827
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109N
Y109N
1
1
0
0
109
Y
N
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,286
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27N
null
null
1
4
null
null
null
0.22
1.15
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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fireprotdb:6632
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,632
train
mutant
6,234
117
6,828
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109Q
Y109Q
1
1
0
0
109
Y
Q
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,287
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27Q
null
null
1.8
3.2
null
null
null
0.26
1.27
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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fireprotdb:6633
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,633
train
mutant
6,235
117
6,829
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109R
Y109R
1
1
0
0
109
Y
R
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,288
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27R
null
null
2.1
2.9
null
null
null
0.3
1.29
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6634
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,634
train
mutant
6,236
117
6,830
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109S
Y109S
1
1
0
0
109
Y
S
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,289
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27S
null
null
2
3
null
null
null
0.26
1.32
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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fireprotdb:6635
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,635
train
mutant
6,237
117
6,831
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109T
Y109T
1
1
0
0
109
Y
T
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,290
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27T
null
null
1.7
3.3
null
null
null
0.32
1.07
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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fireprotdb:6636
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,636
train
mutant
6,238
117
6,832
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109V
Y109V
1
1
0
0
109
Y
V
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,291
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27V
null
null
2
3
null
null
null
0.45
0.76
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6637
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,637
train
mutant
6,239
117
6,833
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Y109W
Y109W
1
1
0
0
109
Y
W
3
CONSERVATION
1STN
140
null
109
A
E
true
false
24.339552
18.9775
13,292
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Y27W
null
null
4.4
0.6
null
null
null
0.7
1.08
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
841
ARTICLE
Stability studies of amino acid substitutions at tyrosine 27 of the staphylococcal nuclease beta-barrel.
1,997
10.1021/bi970876r
9315853
Biochemistry;36;12167-74
5
Fox R O|Bhat M G|Ganley L M|Ledman D W|Goodman M A
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[{"id":7879,"numValue":3.0,"position":109,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6638
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,638
train
mutant
1,276
117
1,426
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110F
K110F
1
1
0
0
110
K
F
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
2,440
ProTherm
7
CD
Thermal
Phosphate
25 mM
null
NaCl
100 mM
1STN_A:K28F
48.5
-4.2
null
null
null
null
91
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1962.csv|Broom_S605.csv|Saraboji_S2204.csv|STRUM_Q3421.csv|EASE-MM_S543.csv|PoPMuSiC-2.0_S2648.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
225
ARTICLE
Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation.
2,007
10.1016/j.bpc.2006.10.014
17134819
Biophys Chem;125;490-6
2
Byrne Michael P|Stites Wesley E
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[{"datasets":["AUTOMUTE_S1962.csv","Broom_S605.csv","Saraboji_S2204.csv","STRUM_Q3421.csv"],"id":8970,"numValue":48.5,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1962.csv","EASE-MM_S543.csv","PoPMuSiC-2.0_S2648.csv","STRUM_Q3421.csv"],"id":8971,"numValue":-4.2,"references":[],"strValue":null,"t...
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fireprotdb:6640
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,640
train
mutant
1,276
117
1,426
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110F
K110F
1
1
0
0
110
K
F
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
13,335
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K28F
null
null
4.6
0.9
null
null
null
0.71
0.99
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
845
ARTICLE
Stability effects of increasing the hydrophobicity of solvent-exposed side chains in staphylococcal nuclease.
1,998
10.1021/bi9725069
9578580
Biochemistry;37;6939-48
4
Stites W E|Schwehm J M|Kristyanne E S|Biggers C C
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6641
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,641
train
mutant
5,988
117
6,558
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110A
K110A
1
1
0
0
110
K
A
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
12,862
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K28A
null
null
4.9
0.7
null
null
null
0.7
1.02
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
827
ARTICLE
Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.
1,996
10.1021/bi960171+
8639591
Biochemistry;35;6443-9
3
Shortle D|Garcia-Moreno B|Meeker A K
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fireprotdb:6642
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,642
train
mutant
5,988
117
6,558
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110A
K110A
1
1
0
0
110
K
A
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
13,554
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K28A
null
null
4.7
0.7
null
null
null
0.7
1.02
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
856
ARTICLE
Evidence for strained interactions between side-chains and the polypeptide backbone.
1,994
10.1016/s0022-2836(05)80008-7
8289248
J Mol Biol;235;27-32
3
Shortle D|Stites W E|Meeker A K
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6643
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,643
train
mutant
5,989
117
6,559
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110G
K110G
1
1
0
0
110
K
G
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
12,863
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K28G
null
null
4.9
0.7
null
null
null
0.67
1.04
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
827
ARTICLE
Contributions of the ionizable amino acids to the stability of staphylococcal nuclease.
1,996
10.1021/bi960171+
8639591
Biochemistry;35;6443-9
3
Shortle D|Garcia-Moreno B|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6644
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,644
train
mutant
5,989
117
6,559
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110G
K110G
1
1
0
0
110
K
G
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
13,555
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:K28G
null
null
4.7
0.7
null
null
null
0.67
1.04
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
856
ARTICLE
Evidence for strained interactions between side-chains and the polypeptide backbone.
1,994
10.1016/s0022-2836(05)80008-7
8289248
J Mol Biol;235;27-32
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6645
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,645
train
mutant
6,045
117
6,630
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110E
K110E
1
1
0
0
110
K
E
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
12,922
ProTherm
7
Fluorescence
GdnHCl
sodium phosphate
25 mM
20
sodium chloride
100 mM
1STN_A:K28E
null
null
4.6
0.8
null
null
null
0.7
6.53
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
828
ARTICLE
Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects.
2,003
10.1021/bi0266434
12549934
Biochemistry;42;1118-28
5
Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6646
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,646
train
mutant
6,046
117
6,631
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
K110Q
K110Q
1
1
0
0
110
K
Q
5
CONSERVATION
1STN
140
null
110
A
T
false
false
156.829734
35.44
12,923
ProTherm
7
Fluorescence
GdnHCl
sodium phosphate
25 mM
20
sodium chloride
100 mM
1STN_A:K28Q
null
null
5.1
0.3
null
null
null
0.78
6.53
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
828
ARTICLE
Changes in stability upon charge reversal and neutralization substitution in staphylococcal nuclease are dominated by favorable electrostatic effects.
2,003
10.1021/bi0266434
12549934
Biochemistry;42;1118-28
5
Stites Wesley E|Schwehm Jeffery M|Fitch Carolyn A|Dang Bao N|Garc?a-Moreno E Bertrand
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7880,"numValue":5.0,"position":110,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6647
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,647
train
mutant
1,277
117
1,427
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111F
G111F
1
1
0
0
111
G
F
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
2,441
ProTherm
7
CD
Thermal
Phosphate
25 mM
null
NaCl
100 mM
1STN_A:G29F
46.3
-6.4
null
null
null
null
87
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
225
ARTICLE
Thermal denaturations of staphylococcal nuclease wild-type and mutants monitored by fluorescence and circular dichroism are similar: lack of evidence for other than a two state thermal denaturation.
2,007
10.1016/j.bpc.2006.10.014
17134819
Biophys Chem;125;490-6
2
Byrne Michael P|Stites Wesley E
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","type":"ION"},{"nu...
[{"datasets":[],"id":8974,"numValue":46.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":8975,"numValue":-6.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":8976,"numValue":87.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":8977,"numValue":null,"references":[],"...
[{"id":7881,"numValue":7.0,"position":111,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6649
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,649
train
mutant
1,277
117
1,427
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111F
G111F
1
1
0
0
111
G
F
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
4,262
ProTherm
7
Fluorescence
Thermal
Sodium phosphate
25 mM
null
NaCl
100 mM
1STN_A:G29F
47.3
-5.7
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
407
ARTICLE
Chemically crosslinked protein dimers: stability and denaturation effects.
1,995
10.1002/pro.5560041211
8580845
Protein Sci;4;2545-58
2
Stites W E|Byrne M P
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"NaCl","...
[{"datasets":[],"id":15800,"numValue":47.3,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":15801,"numValue":-5.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":15802,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":7881,"numValue":7.0,"position":111,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6650
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,650
train
mutant
1,277
117
1,427
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111F
G111F
1
1
0
0
111
G
F
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
13,336
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:G29F
null
null
4.1
1.4
null
null
null
0.57
1.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
845
ARTICLE
Stability effects of increasing the hydrophobicity of solvent-exposed side chains in staphylococcal nuclease.
1,998
10.1021/bi9725069
9578580
Biochemistry;37;6939-48
4
Stites W E|Schwehm J M|Kristyanne E S|Biggers C C
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":49035,"numValue":4.1,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":49036,"numValue":1.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":49037,"numValue":1.09,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":49038,"numValue":0.57,"references":[],"s...
[{"id":7881,"numValue":7.0,"position":111,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6651
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,651
train
mutant
1,277
117
1,427
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111F
G111F
1
1
0
0
111
G
F
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
13,611
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:G29F
null
null
4.4
1.1
null
null
null
0.59
7.43
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
407
ARTICLE
Chemically crosslinked protein dimers: stability and denaturation effects.
1,995
10.1002/pro.5560041211
8580845
Protein Sci;4;2545-58
2
Stites W E|Byrne M P
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
[{"datasets":[],"id":50353,"numValue":4.4,"references":[],"strValue":null,"type":"DG"},{"datasets":["SAAFEC_S983.csv"],"id":50354,"numValue":1.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":50355,"numValue":7.43,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":50356,"numValue":0.59,"...
[{"id":7881,"numValue":7.0,"position":111,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6652
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,652
train
mutant
2,160
117
2,454
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111C
G111C
1
1
0
0
111
G
C
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
4,253
ProTherm
7
Fluorescence
Thermal
Sodium phosphate
25 mM
null
NaCl
100 mM
1STN_A:G29C
48.4
-4.6
null
null
null
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
407
ARTICLE
Chemically crosslinked protein dimers: stability and denaturation effects.
1,995
10.1002/pro.5560041211
8580845
Protein Sci;4;2545-58
2
Stites W E|Byrne M P
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fireprotdb:6653
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,653
train
mutant
2,160
117
2,454
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111C
G111C
1
1
0
0
111
G
C
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
13,602
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:G29C
null
null
4.4
1.1
null
null
null
0.62
7.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
407
ARTICLE
Chemically crosslinked protein dimers: stability and denaturation effects.
1,995
10.1002/pro.5560041211
8580845
Protein Sci;4;2545-58
2
Stites W E|Byrne M P
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6654
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,654
train
mutant
6,126
117
6,714
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111A
G111A
1
1
0
0
111
G
A
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
13,038
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:G29A
null
null
4.2
1.3
null
null
null
0.57
1.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
833
ARTICLE
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.
1,992
10.1021/bi00140a005
1610820
Biochemistry;31;5717-28
3
Shortle D|Meeker A K|Green S M
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6655
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,655
train
mutant
6,126
117
6,714
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
G111A
G111A
1
1
0
0
111
G
A
7
CONSERVATION
1STN
140
null
111
A
T
false
false
72.719287
26.38
13,561
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:G29A
null
null
4.2
1.2
null
null
null
0.57
1.09
null
null
null
null
null
null
null
Unknown
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
856
ARTICLE
Evidence for strained interactions between side-chains and the polypeptide backbone.
1,994
10.1016/s0022-2836(05)80008-7
8289248
J Mol Biol;235;27-32
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6657
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,657
train
mutant
6,151
117
6,739
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Q112G
Q112G
1
1
0
0
112
Q
G
5
CONSERVATION
1STN
140
null
112
A
E
false
false
102.706926
45.907778
13,064
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Q30G
null
null
4.6
0.9
null
null
null
0.66
1.01
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
833
ARTICLE
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.
1,992
10.1021/bi00140a005
1610820
Biochemistry;31;5717-28
3
Shortle D|Meeker A K|Green S M
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7882,"numValue":5.0,"position":112,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6658
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,658
train
mutant
6,152
117
6,740
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
Q112A
Q112A
1
1
0
0
112
Q
A
5
CONSERVATION
1STN
140
null
112
A
E
false
false
102.706926
45.907778
13,065
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:Q30A
null
null
5.2
0.3
null
null
null
0.77
0.99
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
833
ARTICLE
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.
1,992
10.1021/bi00140a005
1610820
Biochemistry;31;5717-28
3
Shortle D|Meeker A K|Green S M
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7882,"numValue":5.0,"position":112,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6659
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,659
train
mutant
6,115
117
6,703
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
P113G
P113G
1
1
0
0
113
P
G
4
CONSERVATION
1STN
140
null
113
A
E
false
false
76.508395
22.568571
13,026
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:P31G
null
null
3.9
1.6
null
null
null
0.59
0.98
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
833
ARTICLE
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.
1,992
10.1021/bi00140a005
1610820
Biochemistry;31;5717-28
3
Shortle D|Meeker A K|Green S M
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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[{"id":7883,"numValue":4.0,"position":113,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6660
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,660
train
mutant
6,116
117
6,704
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
P113A
P113A
1
1
0
0
113
P
A
4
CONSERVATION
1STN
140
null
113
A
E
false
false
76.508395
22.568571
13,027
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:P31A
null
null
5
0.5
null
null
null
0.77
0.95
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
833
ARTICLE
Contributions of the polar, uncharged amino acids to the stability of staphylococcal nuclease: evidence for mutational effects on the free energy of the denatured state.
1,992
10.1021/bi00140a005
1610820
Biochemistry;31;5717-28
3
Shortle D|Meeker A K|Green S M
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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fireprotdb:6662
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,662
train
mutant
2,096
117
2,337
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114L
M114L
1
1
0
0
114
M
L
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
4,123
ProTherm
7
Fluorescence
Thermal
NaOH
25 mM
null
1STN_A:M32L
50.3
-3.2
null
null
null
null
81
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
382
ARTICLE
The M32L substitution of staphylococcal nuclease: disagreement between theoretical prediction and experimental protein stability.
1,996
10.1006/jmbi.1996.0180
8648619
J Mol Biol;257;497-9
2
Stites W E|Spencer D S
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaOH","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1STN_A:M32L","type"...
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fireprotdb:6663
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,663
train
mutant
2,096
117
2,337
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114L
M114L
1
1
0
0
114
M
L
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
13,545
ProTherm
7
Fluorescence
GdnHCl
NaOH
25 mM
20
1STN_A:M32L
null
null
4.7
0.8
null
null
null
0.72
6.47
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
382
ARTICLE
The M32L substitution of staphylococcal nuclease: disagreement between theoretical prediction and experimental protein stability.
1,996
10.1006/jmbi.1996.0180
8648619
J Mol Biol;257;497-9
2
Stites W E|Spencer D S
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"NaOH","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFF...
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[{"id":7884,"numValue":5.0,"position":114,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6664
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,664
train
mutant
2,097
117
2,338
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114I
M114I
1
1
0
0
114
M
I
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
4,124
ProTherm
7
Fluorescence
Thermal
NaOH
25 mM
null
1STN_A:M32I
51.2
-2.3
null
null
null
null
87
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
382
ARTICLE
The M32L substitution of staphylococcal nuclease: disagreement between theoretical prediction and experimental protein stability.
1,996
10.1006/jmbi.1996.0180
8648619
J Mol Biol;257;497-9
2
Stites W E|Spencer D S
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaOH","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1STN_A:M32I","type"...
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fireprotdb:6665
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,665
train
mutant
2,097
117
2,338
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114I
M114I
1
1
0
0
114
M
I
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
13,546
ProTherm
7
Fluorescence
GdnHCl
NaOH
25 mM
20
1STN_A:M32I
null
null
4.9
0.6
null
null
null
0.75
6.57
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
SAAFEC_S1262.csv|SAAFEC_S983.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
382
ARTICLE
The M32L substitution of staphylococcal nuclease: disagreement between theoretical prediction and experimental protein stability.
1,996
10.1006/jmbi.1996.0180
8648619
J Mol Biol;257;497-9
2
Stites W E|Spencer D S
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"NaOH","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFF...
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fireprotdb:6666
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,666
train
mutant
6,316
117
6,916
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114A
M114A
1
1
0
0
114
M
A
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
13,451
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M32A
null
null
3.78
1.7
null
null
null
0.5
1.06
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
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[{"id":7884,"numValue":5.0,"position":114,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:6667
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
6,667
train
mutant
6,317
117
6,917
231
231
11
Thermonuclease
Staphylococcus aureus
1
11
Thermonuclease
Staphylococcus aureus
1
P00644
IPR035437|IPR016071|IPR002071
3.1.31.1
M114G
M114G
1
1
0
0
114
M
G
5
CONSERVATION
1STN
140
null
114
A
E
true
false
40.390885
25.83125
13,452
ProTherm
7
Fluorescence
GdnHCl
Sodium phosphate
25 mM
20
NaCl
100 mM
1STN_A:M32G
null
null
3.08
2.4
null
null
null
0.4
1.09
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
guerios_625_map.csv|potapov_with_uniprot_mapping.csv|SAAFEC_S1262.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
850
ARTICLE
Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease.
1,990
10.1021/bi00487a007
2261461
Biochemistry;29;8033-41
3
Shortle D|Stites W E|Meeker A K
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":20.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM",...
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