LiteFold/InterPro · Datasets at Hugging Face

IPR013466

13,466

Thymidine phosphorylase/AMP phosphorylase

Thymidine/AMP_Pase

Family

1,882

false

Proteins in this entry are closely related to characterised examples of thymidine phosphorylase ( ) and pyrimidine nucleoside phosphorylase ( ). Many examples are found in the archaea, but other examples are found in bacteria such as Legionella pneumophila (strain Paris) and Rhodopseudomonas palustris CGA009.

[ "GO:0016763" ]

[ "pentosyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02645" ]

[ "ARCH_P_rylase" ]

[ 1882 ]

1

[ "EC" ]

[ "2.4.2" ]

[ "EC:2.4.2" ]

1

[ "4ga4", "4ga5", "4ga6" ]

3

[]

0

[ "IPR000053" ]

[ "IPR017713", "IPR028579" ]

1

2

0

[ "Archaea", "Bacteria", "Neophaeococcomyces mojaviensis", "metagenomes" ]

[ 424, 1437, 1, 20 ]

4

[]

0

true

Family

Thymidine phosphorylase/AMP phosphorylase

Thymidine/AMP_Pase

3

IPR013467

13,467

Retron Ec78 putative HNH endonuclease-like

HNH78-like

Family

1,201

false

This entry represents a bacterial family of proteins that includes several putative HNH endonucleases that form part of antiviral defense systems such as Ec78, Ec83 and Vc95. These proteins confer protection against specific phages [ ]. This entry also includes Septu protein PtuB, a component of antiviral defense syste...

[]

0

[ "NCBIFAM" ]

[ "TIGR02646" ]

[ "" ]

[ 1201 ]

1

[]

0

[ "8ee7", "8eea", "9e8z", "9e90", "9kjx", "9kjy", "9kjz", "9kk1", "9kk2", "9n69", "9n6b", "9nnb", "9nnh", "9nnk", "9o4a" ]

15

[ "PUB00097806", "PUB00101106" ]

[ "29371424", "33157039" ]

[ "Systematic discovery of antiphage defense systems in the microbial pangenome.", "Bacterial Retrons Function In Anti-Phage Defense." ]

[ 2018, 2020 ]

2

[]

0

null

[ "Bacteria", "Methanomicrobia", "metagenomes" ]

[ 1186, 2, 13 ]

3

[]

0

true

Family

Retron Ec78 putative HNH endonuclease-like

HNH78-like

9

IPR013468

13,468

Conserved hypothetical protein CHP02647

CHP02647

Family

1,579

false

Proteins in this entry are found, so far, only in the Gammaproteobacteria. Their function is currently unknown. The location on the chromosome is usually not far from housekeeping genes. Some proteins have been annotated in public databases as DNA-binding protein inhibitor-related, putative transcriptional regulators, ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF18918", "TIGR02647" ]

[ "DUF5669", "DNA" ]

[ 1579, 1577 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ditylenchus dipsaci", "unclassified sequences" ]

[ 1553, 1, 25 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP02647

CHP02647

5

IPR013469

13,469

Ribonuclease BN

Rnase_BN

Family

777

false

This entry represents the ribonuclease Z (RNase Z) homologue, RNase BN, from bacteria. RNase BN was considered to be an exonuclease based on its ability to remove the 3'-terminal residue of tRNAs ending in CA, CU, CCU or even CCA [ ]. In E. coli, even though different set of enzymes are used for tRNA 3'-ends processing...

[ "GO:0016891" ]

[ "RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02649" ]

[ "true_RNase_BN" ]

[ 777 ]

1

[ "GP" ]

[ "GenProp1360" ]

[ "GP:GenProp1360" ]

1

[ "2cbn" ]

1

[ "PUB00083319", "PUB00083321" ]

[ "17363966", "8422961" ]

[ "When all's zed and done: the structure and function of RNase Z in prokaryotes.", "Multiple exoribonucleases are required for the 3' processing of Escherichia coli tRNA precursors in vivo." ]

[ 2007, 1993 ]

2

[ "IPR013471" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 777 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribonuclease BN

Rnase_BN

3

IPR013470

13,470

Ribonuclease Z, Thermotoga-type

RNase_Z_T_toga

Family

5

false

All tRNA molecules are synthesised as long precursors with extra sequence at both the 5' and 3' ends, which undergo several processing steps to form the mature tRNA molecule. In many bacteria, the tRNA precursors do not contain the CCA sequence which forms the 3' end of the mature tRNA and is essential for aminoacylati...

[]

0

[ "NCBIFAM" ]

[ "TIGR02650" ]

[ "RNase_Z_T_toga" ]

[ 5 ]

1

[]

0

[ "1ww1", "2e7y" ]

2

[ "PUB00021022", "PUB00047351" ]

[ "15701599", "17671357" ]

[ "Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.", "The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes." ]

[ 2005, 2007 ]

2

[]

0

null

[ "Thermotoga" ]

[ 5 ]

1

[]

0

true

Family

Ribonuclease Z, Thermotoga-type

RNase_Z_T_toga

9

IPR013471

13,471

Ribonuclease Z/BN

RNase_Z/BN

Family

14,999

false

This entry includes ribonuclease Z (RNase Z) and its orthologues, such as RNase BN (also known as elaC) from E.coli. They are ribonucleases that have functions in tRNA-3' processing. RNase Z orthologues are present in all eukaryotes and archaea sequenced so far, and are widely distributed in bacteria [ , ]. All tRNAs a...

[ "GO:0016891" ]

[ "RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_01818", "TIGR02651", "cd07717" ]

[ "RNase_Z_BN", "RNase_Z", "RNaseZ_ZiPD-like_MBL-fold" ]

[ 14657, 8833, 13755 ]

3

[ "EC", "GP" ]

[ "3.1.26.11", "GenProp1360" ]

[ "EC:3.1.26.11", "GP:GenProp1360" ]

2

[ "1y44", "2cbn", "2fk6", "3zwf", "4gcw" ]

5

[ "PUB00032600", "PUB00083319", "PUB00083320", "PUB00083321" ]

[ "12941704", "17363966", "12032089", "8422961" ]

[ "Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis.", "When all's zed and done: the structure and function of RNase Z in prokaryotes.", "Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes.", "Multiple exoribonucleases are required for the...

[ 2003, 2007, 2002, 1993 ]

4

[]

[ "IPR013469" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 919, 11702, 2307, 2, 69 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 2, 1, 3, 1, 2, 2, 8 ]

8

true

Family

Ribonuclease Z/BN

RNase_Z/BN

3

IPR013472

13,472

Conserved hypothetical protein CHP02652

CHP02652

Family

328

false

These conserved hypothetical proteins have so far been found only in the Cyanobacteria. They are about 170 amino acids long and contain a CxxCx(14)CxxH motif near the N terminus.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09654", "TIGR02652" ]

[ "DUF2396", "" ]

[ 328, 322 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 328 ]

1

[]

0

true

Family

Conserved hypothetical protein CHP02652

CHP02652

8

IPR013473

13,473

Lon-like protease BrxL

BrxL

Family

1,051

false

This family represents the Lon-like protease BrxL, including BrxL from Bacillus cereus, which is part of a type 1 BREX system. BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA [ ,...

[]

0

[ "NCBIFAM" ]

[ "TIGR02653" ]

[ "Lon_rel_chp" ]

[ 1051 ]

1

[]

0

[ "8emc", "8emh" ]

2

[ "PUB00093365", "PUB00097935" ]

[ "25452498", "30418590" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes.", "BREX system of Escherichia coli distinguishes self from non-self by methylation of a specific DNA site." ]

[ 2015, 2019 ]

2

[ "IPR014061" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 984, 60, 7 ]

3

[]

0

true

Family

Lon-like protease BrxL

BrxL

7

IPR013474

13,474

Circadian clock protein KaiB

Circ_KaiB

Family

394

false

The cyanobacterial circadian clock protein KaiB is encoded in the kaiABC operon that controls circadian rhythms. It is a component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria [ , , ]. KaiB forms homodimers, homotetramers, and multimeric complexes with KaiA and/or...

[ "GO:0007623", "GO:0042326" ]

[ "circadian rhythm", "negative regulation of phosphorylation" ]

[ "biological_process", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01835", "TIGR02654" ]

[ "KaiB", "circ_KaiB" ]

[ 381, 394 ]

2

[ "GP" ]

[ "GenProp0465" ]

[ "GP:GenProp0465" ]

1

[ "1r5p", "1vgl", "1wwj", "2qke", "4kso", "5jwo", "5jwq", "5jwr", "5jyt", "5jyv", "5n8y" ]

11

[ "PUB00012817", "PUB00021023", "PUB00080802", "PUB00080803", "PUB00084319", "PUB00103593" ]

[ "10064581", "15716274", "12727878", "12727879", "9727980", "31767776" ]

[ "Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria.", "Tetrameric architecture of the circadian clock protein KaiB. A novel interface for intermolecular interactions and its impact on the circadian rhythm.", "Cyanobacterial circadian clockwork: roles of KaiA, KaiB and the...

[ 1999, 2005, 2003, 2003, 1998, 2020 ]

6

[ "IPR039022" ]

[]

1

0

1

[ "Cyanobacteriota" ]

[ 394 ]

1

[]

0

true

Family

Circadian clock protein KaiB

Circ_KaiB

9

IPR013475

13,475

Amicyanin, Paracoccus/Methylobacterium

Amicyanin_Para/Methyl

Family

34

false

Amicyanin is a type I blue copper protein that accepts electrons from the tryptophan tryptophylquinone (TTQ) cofactor of the methylamine dehydrogenase light chain and then transfers them to the haem group of cytochrome c-551i. Amicyanin, methylamine dehydrogenase, and cytochrome c-551i are located in the periplasm and ...

[ "GO:0005507", "GO:0009055" ]

[ "copper ion binding", "electron transfer activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR02657" ]

[ "amicyanin" ]

[ 34 ]

1

[]

0

[ "1aac", "1aaj", "1aan", "1bxa", "1id2", "1mda", "1mg2", "1mg3", "1sf3", "1sf5", "1sfd", "1sfh", "1t5k", "2gb2", "2gba", "2gc4", "2gc7", "2idq", "2ids", "2idt", "2idu", "2j55", "2j56", "2j57", "2mta", "2ov0", "2qdv", "2qdw", "2rac", "3c75", "3ie9", "3iea"...

37

[]

0

[ "IPR035668" ]

[]

1

0

1

[ "Alphaproteobacteria" ]

[ 34 ]

1

[]

0

true

Family

Amicyanin, Paracoccus/Methylobacterium

Amicyanin_Para/Methyl

1

IPR013476

13,476

Methylamine dehydrogenase heavy chain

MeN_DH_Hvc

Family

52

false

Methylamine dehydrogenase is a periplasmic enzyme found in Gram-negative methylotrophs and consists of a heavy chain (large subunit) and a light chain (small subunit), forming a heterotetramer [ ]. It is induced when grown on methylamine as a growth substrate and catalyses the oxidative deamination of primary amines to...

[ "GO:0030058", "GO:0030416", "GO:0042597" ]

[ "aliphatic amine dehydrogenase activity", "methylamine metabolic process", "periplasmic space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR02658" ]

[ "TTQ_MADH_Hv" ]

[ 52 ]

1

[ "EC", "GP", "METACYC" ]

[ "1.4.9.1", "GenProp0860", "PWY-6967" ]

[ "EC:1.4.9.1", "GP:GenProp0860", "METACYC:PWY-6967" ]

3

[ "1mg2", "1mg3", "2bbk", "2gc4", "2gc7", "2j55", "2j56", "2j57", "2mta", "3c75", "3l4m", "3l4o", "3orv", "3pxs", "3pxt", "3pxw", "3rlm", "3rmz", "3rn0", "3rn1", "3sjl", "3sle", "3svw", "3sws", "3sxt", "4fa1", "4fa4", "4fa5", "4fa9", "4fan", "4fav", "4fb1"...

38

[ "PUB00016972" ]

[ "8021187" ]

[ "Genetic organization of the mau gene cluster in Methylobacterium extorquens AM1: complete nucleotide sequence and generation and characteristics of mau mutants." ]

[ 1994 ]

1

[ "IPR009451" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 52 ]

1

[]

0

true

Family

Methylamine dehydrogenase heavy chain

MeN_DH_Hvc

5

IPR013477

13,477

Homocitrate synthase NifV-like

NifV/FrbC

Family

1,622

false

Homocitrate synthase NifV catalyzes the condensation of acetyl coenzyme A and 2-oxoglutarate to form homocitrate and CoA. Homocitrate is a component of the FeMo-cofactor present in the catalytic centre of dinitrogenase [ ]. This family includes the NifV proteins of Heliobacterium chlorum [ ] and Gluconacetobacter diazo...

[ "GO:0046912" ]

[ "acyltransferase activity, acyl groups converted into alkyl on transfer" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "CDD" ]

[ "TIGR02660", "cd07939" ]

[ "nifV_homocitr", "DRE_TIM_NifV" ]

[ 1396, 1562 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.3.3.14", "GenProp0029", "PWY-3081", "PWY-7710" ]

[ "EC:2.3.3.14", "GP:GenProp0029", "METACYC:PWY-3081", "METACYC:PWY-7710" ]

4

[]

0

[ "PUB00081199", "PUB00081200", "PUB00081201", "PUB00081202", "PUB00088726" ]

[ "18721747", "18314963", "16403868", "11092875", "28348373" ]

[ "Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098.", "Assembly of nitrogenase MoFe protein.", "Molecular evolution of the nif gene cluster carrying nifI1 and nifI2 genes in the Gram-positive phototrophic bacter...

[ 2008, 2008, 2006, 2000, 2017 ]

5

[]

0

null

[ "Bacteria", "Methanobacteriati", "unclassified sequences" ]

[ 1587, 14, 21 ]

3

[]

0

true

Family

Homocitrate synthase NifV-like

NifV/FrbC

3

IPR013478

13,478

Methylamine dehydrogenase accessory protein MauD

MeN_DH_accessory

Family

449

false

MauD appears critical to proper formation of the small subunit of methylamine dehydrogenase, which has both an unusual tryptophan tryptophylquinone cofactor and multiple disulphide bonds. MauD shares sequence similarity, including a CPxC motif, with a number of thiol:disulphide interchange proteins. In MauD mutants, th...

[ "GO:0030416" ]

[ "methylamine metabolic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR02661" ]

[ "MauD" ]

[ 449 ]

1

[ "GP" ]

[ "GenProp0860" ]

[ "GP:GenProp0860" ]

1

[]

0

[ "PUB00013087" ]

[ "9403107" ]

[ "MauE and MauD proteins are essential in methylamine metabolism of Paracoccus denitrificans." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 441, 8 ]

2

[]

0

true

Family

Methylamine dehydrogenase accessory protein MauD

MeN_DH_accessory

4

IPR013479

13,479

ADP-ribosyl-dinitrogen reductase hydrolase

ADP-ribosyl_diN_reduct_hydro

Family

407

false

This entry represents ADP-ribosyl-dinitrogen reductase hydrolase ( ), also known as dinitrogenase reductase activating glycohydrolase (DraG). It is involved in the regulation of nitrogen fixation activity by the reversible ADP-ribosylation of the dinitrogenase reductase component of the nitrogenase enzyme complex [ ]. ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02662" ]

[ "dinitro_DRAG" ]

[ 407 ]

1

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[ "2woc", "2wod", "2woe", "3g9d", "3o5t", "5ovo" ]

6

[ "PUB00033865" ]

[ "16417510" ]

[ "Metabolic regulation of nitrogen fixation in Rhodospirillum rubrum." ]

[ 2006 ]

1

[ "IPR005502" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 396, 11 ]

2

[]

0

true

Family

ADP-ribosyl-dinitrogen reductase hydrolase

ADP-ribosyl_diN_reduct_hydro

1

IPR013480

13,480

Nitrogen fixation protein NifX

NifX

Family

1,047

false

NifX is involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-Co) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing bacteria. This complex catalyses the reduction of atmospheric dinitrogen to ammonia. The role of NifX in cofactor biosynthesis is not fully understood, though it...

[ "GO:0051540", "GO:0009399" ]

[ "metal cluster binding", "nitrogen fixation" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02663" ]

[ "nifX" ]

[ 1047 ]

1

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[ "1p90" ]

1

[ "PUB00016259" ]

[ "11279153" ]

[ "Accumulation of 55Fe-labeled precursors of the iron-molybdenum cofactor of nitrogenase on NifH and NifX of Azotobacter vinelandii." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1035, 12 ]

2

[]

0

true

Family

Nitrogen fixation protein NifX

NifX

1

IPR013482

13,482

Molybdenum cofactor guanylyltransferase

Molybde_CF_guanTrfase

Family

17,493

false

In many molybdopterin-containing enzymes, including nitrate reductase and dimethylsulfoxide reductase, the cofactor is molybdopterin-guanine dinucleotide (molybdopterin modified by attachment of a GMP group to the terminal phosphate). This entry represents the molybdenum cofactor guanylyltransferase MobA. In E. coli, M...

[ "GO:0003824", "GO:0006777" ]

[ "catalytic activity", "Mo-molybdopterin cofactor biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00316", "TIGR02665", "cd02503" ]

[ "MobA", "molyb_mobA", "MobA" ]

[ 13338, 7086, 17431 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC" ]

[ "2.7.7.77", "GenProp0466", "GenProp1409", "PWY-5964", "PWY-8168" ]

[ "EC:2.7.7.77", "GP:GenProp0466", "GP:GenProp1409", "METACYC:PWY-5964", "METACYC:PWY-8168" ]

5

[ "1e5k", "1fr9", "1frw", "1h4c", "1h4d", "1h4e", "1hjj", "1hjl", "2e8b", "3ngw" ]

10

[ "PUB00015694", "PUB00060606", "PUB00060607", "PUB00060608" ]

[ "8020507", "1648082", "10978348", "21081498" ]

[ "Isolation of protein FA, a product of the mob locus required for molybdenum cofactor biosynthesis in Escherichia coli.", "Molybdenum cofactor biosynthesis in Escherichia coli. Requirement of the chlB gene product for the formation of molybdopterin guanine dinucleotide.", "Mechanism of assembly of the Bis(Molyb...

[ 1994, 1991, 2000, 2011 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 812, 16180, 153, 348 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Molybdenum cofactor guanylyltransferase

Molybde_CF_guanTrfase

6

IPR013483

13,483

Molybdenum cofactor biosynthesis protein A

MoaA

Family

24,695

false

This entry represents the MoaA protein (molybdenum cofactor biosynthesis protein A), also known as cyclic pyranopterin monophosphate synthase or GTP 3',8-cyclase. MoaA is a member of the wider S-adenosylmethionine(SAM)-dependent enzyme family which catalyze the formation of protein and/or substrate radicals by reductiv...

[ "GO:0046872", "GO:0006777" ]

[ "metal ion binding", "Mo-molybdopterin cofactor biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01225_B", "TIGR02666" ]

[ "MoaA_B", "moaA" ]

[ 20918, 24630 ]

2

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.99.22", "GenProp0466", "GenProp1711", "PWY-6823", "R-BTA-947581", "R-DDI-947581", "R-DME-947581", "R-HSA-947581", "R-MMU-947581" ]

[ "EC:4.1.99.22", "GP:GenProp0466", "GP:GenProp1711", "METACYC:PWY-6823", "REACTOME:R-BTA-947581", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-HSA-947581", "REACTOME:R-MMU-947581" ]

9

[ "1tv7", "1tv8", "2fb2", "2fb3" ]

4

[ "PUB00015124", "PUB00015635", "PUB00015921", "PUB00034757", "PUB00034758", "PUB00034759", "PUB00036007" ]

[ "15317939", "12372836", "8528286", "12114025", "17198377", "16784786", "16632608" ]

[ "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.", "In vivo interactions between gene products involved in the final stages of molybdenum cofactor biosynthesis in Escherichia coli.", "Molybdenum co-factor biosynthesis: the Ar...

[ 2004, 2002, 1995, 2002, 2007, 2006, 2006 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 32, 20510, 3839, 314 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 3, 2, 1, 1, 3, 1, 1, 7, 3, 3 ]

11

true

Family

Molybdenum cofactor biosynthesis protein A

MoaA

2

IPR013484

13,484

Molybdenum cofactor biosynthesis protein B, proteobacteria

MoaB_proteobac

Family

6,448

false

MoaB is thought to be involved in molybdopterin biosynthesis, though its exact role is not known. Structural studies of this polypeptide suggest that it may play a role in substrate-shuttling during biosynthesis [ ]. MoaB was capable of binding GTP, and it was suggested that the putative active site could also bind pre...

[ "GO:0006777" ]

[ "Mo-molybdopterin cofactor biosynthetic process" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR02667" ]

[ "moaB_proteo" ]

[ 6448 ]

1

[ "GP" ]

[ "GenProp0466" ]

[ "GP:GenProp0466" ]

1

[ "1mkz", "1r2k" ]

2

[ "PUB00015825" ]

[ "15269205" ]

[ "The crystal structure of Escherichia coli MoaB suggests a probable role in molybdenum cofactor synthesis." ]

[ 2004 ]

1

[ "IPR012245" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6362, 4, 82 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Molybdenum cofactor biosynthesis protein B, proteobacteria

MoaB_proteobac

8

IPR013485

13,485

Molybdenum cofactor biosynthesis protein A, archaea

MoaA_arc

Family

732

false

This entry consists of archaeal proteins which are predicted to be functionally equivalent to MoaA (molybdenum cofactor biosynthesis protein A, cyclic pyranopterin monophosphate synthase or GTP 3',8-cyclase) from bacteria (see ).

[ "GO:0046872", "GO:0006777" ]

[ "metal ion binding", "Mo-molybdopterin cofactor biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01225_A", "TIGR02668" ]

[ "MoaA_A", "moaA_archaeal" ]

[ 719, 723 ]

2

[ "EC", "GP", "METACYC" ]

[ "4.1.99.22", "GenProp0466", "PWY-6823" ]

[ "EC:4.1.99.22", "GP:GenProp0466", "METACYC:PWY-6823" ]

3

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 725, 7 ]

2

[]

0

true

Family

Molybdenum cofactor biosynthesis protein A, archaea

MoaA_arc

7

IPR013486

13,486

Sporulation stage II protein D, amidase enhancer LytB

SpoIID/LytB

Family

8,405

false

This entry describes a region which is found, typically in two or three proteins per genome, in Cyanobacteria and Firmicutes, and sporadically in other genomes. One example is SpoIID from Bacillus subtilis. Another, also from B. subtilis, is LytB which contains this region at the C terminus. LytB is encoded immediately...

[ "GO:0030435" ]

[ "sporulation resulting in formation of a cellular spore" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR02669" ]

[ "SpoIID_LytB" ]

[ 8405 ]

1

[]

0

[ "4rwr", "5i1t", "5txu" ]

3

[ "PUB00020772" ]

[ "3129534" ]

[ "The possible DNA-binding nature of the regulatory proteins, encoded by spoIID and gerE, involved in the sporulation of Bacillus subtilis." ]

[ 1987 ]

1

[]

[ "IPR014225" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 8193, 7, 2, 203 ]

4

[]

0

true

Family

Sporulation stage II protein D, amidase enhancer LytB

SpoIID/LytB

5

IPR013487

13,487

CRISPR-associated protein Csx8

CRISPR-assoc_prot_Csx8

Family

82

false

This entry represents the Cxs8 family of Cas proteins, whose function is unknown. These proteins are encoded in the midst of a cas gene operon, immediately upstream of CRISPR-associated autoregulator, DevR family ( ) [ ]. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09657", "TIGR02670" ]

[ "Cas_Csx8", "cas_csx8" ]

[ 82, 79 ]

2

[ "GP" ]

[ "GenProp0021" ]

[ "GP:GenProp0021" ]

1

[]

0

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "16292354", "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2011, 2014 ]

6

[]

0

null

[ "Bacteria" ]

[ 82 ]

1

[]

0

true

Family

CRISPR-associated protein Csx8

CRISPR-assoc_prot_Csx8

7

IPR013488

13,488

CRISPR-associated protein Csx9/Cas8a2

CRISPR-assoc_prot_Csx9/Cas8a2

Family

20

false

This entry represents the Cxs9/Cas8a2 family of Cas proteins found in archaea. These proteins are encoded in the midst of a cas gene operon is found immediately upstream of cas3 in loci that resemble the Apern type but lack Csa1 and Csa4 genes [ ]. The CRISPR-Cas system is a prokaryotic defence mechanism against foreig...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09658", "TIGR02671" ]

[ "Cas_Csx9", "cas_csx9" ]

[ 20, 19 ]

2

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0319" ]

[ "GP:GenProp0021", "GP:GenProp0319" ]

2

[]

0

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "16292354", "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2011, 2014 ]

6

[]

0

null

[ "Archaea", "candidate division WOR-3 bacterium" ]

[ 19, 1 ]

2

[]

0

true

Family

CRISPR-associated protein Csx9/Cas8a2

CRISPR-assoc_prot_Csx9/Cas8a2

7

IPR013489

13,489

CRISPR-associated protein Csm6

CRISPR-assoc_prot_Csm6

Family

265

false

This entry represents the Csm6 family of Cas (CRISPR-associated) proteins [ ] found in bacteria, such as Streptococcus thermophilus CNRZ1066, Staphylococcus epidermidis RP62A, and Mycobacterium tuberculosis (strains CDC1551 and H37Rv), as part of Mtube-type CRISPR/Cas systems, now called type III-A. Csm6 is a CARF (CRI...

[]

0

[ "NCBIFAM" ]

[ "TIGR02672" ]

[ "cas_csm6" ]

[ 265 ]

1

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0318" ]

[ "GP:GenProp0021", "GP:GenProp0318" ]

2

[ "5yjc", "6tug", "8pcw", "8pe3" ]

4

[ "PUB00020781", "PUB00043286", "PUB00085051", "PUB00106904" ]

[ "16292354", "17442114", "24817877", "28722012" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CARF and WYL domains: ligand-binding regulators of prokaryotic defense systems.", "Type III CRISPR-Cas ...

[ 2005, 2007, 2014, 2017 ]

4

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 264, 1 ]

2

[]

0

true

Family

CRISPR-associated protein Csm6

CRISPR-assoc_prot_Csm6

4

IPR013490

13,490

CRISPR-associated RAMP Csx10

CRISPR-assoc_RAMP_Csx10

Family

93

false

This entry represents the Csx10 family of Cas proteins, which are mainly found in cyanobacteria [ ]. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA.

[]

0

[ "NCBIFAM" ]

[ "TIGR02674" ]

[ "cas_cyan_RAMP_2" ]

[ 93 ]

1

[ "GP" ]

[ "GenProp0021" ]

[ "GP:GenProp0021" ]

1

[]

0

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "16292354", "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2011, 2014 ]

6

[]

0

null

[ "Bacteria", "Odinarchaeota yellowstonii (strain LCB_4)" ]

[ 92, 1 ]

2

[]

0

true

Family

CRISPR-associated RAMP Csx10

CRISPR-assoc_RAMP_Csx10

5

IPR013491

13,491

Tape measure protein N-terminal

Tape_meas_N

Domain

8,710

false

This entry is represented by a N-terminal domain of tape measure proteins that characterises the Caudoviruses. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. Proteins containing this domain are found either in bacteriophages or in bacteria, where they are enco...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF20155", "TIGR02675" ]

[ "TMP_3", "tape_meas_nterm" ]

[ 8608, 7907 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "8rk3", "8vjh", "9cuy", "9ki1", "9mjn", "9occ" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "unclassified sequences" ]

[ 6575, 27, 1, 2050, 57 ]

5

[]

0

true

Domain

Tape measure protein N-terminal

Tape_meas_N

9

IPR013492

13,492

CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12

CRISPR-assoc_Cas9/Csx12

Family

29

false

This entry represents a family of large Cas proteins that have so far only been found in CRISPR/cas loci in Francisella tularensis, Wolinella succinogenes DSM 1740, and Legionella pneumophila (strain Paris) [ , ]. One region of this large protein shows sequence similarity to HNH endonuclease . The CRISPR-Cas system is ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03031" ]

[ "cas_csx12" ]

[ 29 ]

1

[ "GP" ]

[ "GenProp0021" ]

[ "GP:GenProp0021" ]

1

[ "5b2o", "5b2p", "5b2q", "8umf", "9ehf", "9ehg", "9ehh", "9ehr", "9ehw", "9ehx", "9ko9", "9kor", "9n6t", "9ua2" ]

14

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890", "PUB00074059" ]

[ "16292354", "17442114", "17379808", "16545108", "21699496", "24459147", "24270795" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2011, 2014, 2014 ]

7

[]

0

null

[ "Pseudomonadati" ]

[ 29 ]

1

[]

0

true

Family

CRISPR system subtype II-B RNA-guided endonuclease Cas9/Csx12

CRISPR-assoc_Cas9/Csx12

6

IPR013493

13,493

Conserved hypothetical protein CHP02677

CHP02677

Family

2,188

false

Proteins in this family are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. (strain EbN1) (...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09660", "TIGR02677" ]

[ "DUF2397", "" ]

[ 2188, 1697 ]

2

[ "GP" ]

[ "GenProp0470" ]

[ "GP:GenProp0470" ]

1

[ "9qe0", "9qe1" ]

2

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2179, 9 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP02677

CHP02677

7

IPR013494

13,494

Conserved hypothetical protein CHP02678

CHP02678

Family

2,116

false

Proteins in this family are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. (strain EbN1) (...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09661", "TIGR02678" ]

[ "DUF2398", "" ]

[ 2116, 1662 ]

2

[ "GP" ]

[ "GenProp0470" ]

[ "GP:GenProp0470" ]

1

[ "9qe0", "9qe1" ]

2

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2109, 7 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP02678

CHP02678

9

IPR013495

13,495

Conserved hypothetical protein CHP02679

CHP02679

Family

1,117

false

Proteins in this family are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. (strain EbN1) (...

[]

0

[ "NCBIFAM" ]

[ "TIGR02679" ]

[ "" ]

[ 1117 ]

1

[ "GP" ]

[ "GenProp0470" ]

[ "GP:GenProp0470" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Syncephalis pseudoplumigaleata", "hydrothermal vent metagenome" ]

[ 1115, 1, 1 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP02679

CHP02679

6

IPR013496

13,496

Conserved hypothetical protein CHP02680

CHP02680

Family

1,774

false

Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. (strain EbN1...

[]

0

[ "NCBIFAM" ]

[ "TIGR02680" ]

[ "" ]

[ 1774 ]

1

[ "GP" ]

[ "GenProp0470" ]

[ "GP:GenProp0470" ]

1

[ "9qe0", "9qe1" ]

2

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1772, 2 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP02680

CHP02680

6

IPR013497

13,497

DNA topoisomerase, type IA, central

Topo_IA_cen

Domain

60,732

false

Type IA topoisomerases are comprised of four domains that together form a toroidal structure with a central hole large enough to accommodate single- and double-stranded DNA: an N-terminal α/β Toprim domain, domain 2 and the C-terminal domain 4 are winged-helix domains, and domain 3 is a β-barrel. Domains 1 (Toprim) and...

[ "GO:0003677", "GO:0003916", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PRINTS", "PROFILE", "CDD" ]

[ "PF01131", "PR00417", "PS52039", "cd00186" ]

[ "Topoisom_bac", "PRTPISMRASEI", "TOPO_IA_2", "TOP1Ac" ]

[ 60460, 57925, 60566, 54113 ]

4

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.1", "R-CEL-5693607", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570", "R-HSA-9709603", "R...

[ "EC:5.6.2.1", "REACTOME:R-CEL-5693607", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-912446...

26

[ "1cy0", "1cy1", "1cy2", "1cy4", "1cy6", "1cy7", "1cy8", "1cy9", "1cyy", "1d6m", "1ecl", "1gku", "1gl9", "1i7d", "1mw8", "1mw9", "2gai", "2gaj", "2o19", "2o54", "2o59", "2o5c", "2o5e", "3pwt", "3px7", "4cgy", "4cht", "4ddt", "4ddu", "4ddv", "4ddw", "4ddx"...

65

[ "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020796", "PUB00020799", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705", "PUB00160232", "PUB00160233", "PUB00160234", "PUB00160235" ]

[ "9488644", "7770916", "11395412", "12596227", "12042765", "14604525", "10574789", "21087076", "20644584", "17722649", "17293019", "16647715", "17141394", "33999213", "25516844" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.",...

[ 1998, 1995, 2001, 2003, 2002, 2003, 1999, 2010, 2010, 2007, 2007, 2006, 2007, 2021, 2014 ]

15

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 1301, 48059, 10134, 60, 10, 1168 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 19, 4, 3, 6, 2, 12, 14, 1, 11, 3, 1, 1, 72 ]

13

true

Domain

DNA topoisomerase, type IA, central

Topo_IA_cen

4

IPR013498

13,498

DNA topoisomerase, type IA, zn finger

Topo_IA_Znf

Domain

27,886

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003916", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase activity", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF01396" ]

[ "Zn_ribbon_Top1" ]

[ 27886 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.1", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9701192", "R-HSA-9704331", "R-HSA-9704646", "R-HSA-9709570", "R-HSA-9709603", "R-HSA-9913635", "R...

[ "EC:5.6.2.1", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA-912446", "REACTOME:R-HSA-9701192...

25

[ "4cgy", "4cht", "4rul", "9gda", "9gdb", "9gdc", "9gdd", "9gde", "9gdh" ]

9

[ "PUB00005230", "PUB00005437", "PUB00016842", "PUB00017144", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "9488644", "7770916", "11395412", "10873443", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "C-terminal domains of Escherichia coli topoisomerase I belong to the zinc-ribbon superfamily.", "Phylogenomics o...

[ 1998, 1995, 2001, 2000, 2003, 2002, 2010, 2010, 2007, 2007 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 909, 23757, 3, 2902, 3, 312 ]

6

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 1, 2, 3, 8, 4, 2, 21 ]

9

true

Domain

DNA topoisomerase, type IA, zn finger

Topo_IA_Znf

5

IPR013499

13,499

DNA topoisomerase I, eukaryotic-type

TopoI_euk

Domain

11,245

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003917", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "SMART" ]

[ "SM00435" ]

[ "TOPEUc" ]

[ 11245 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.1", "R-CEL-4615885", "R-DDI-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885" ]

[ "EC:5.6.2.1", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-HSA-4615885", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615885" ]

8

[ "1a31", "1a35", "1a36", "1ej9", "1k4s", "1k4t", "1lpq", "1nh3", "1r49", "1rr8", "1rrj", "1sc7", "1seu", "1t8i", "1tl8", "2b9s", "6z01", "6z03" ]

18

[ "PUB00004398", "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "1849260", "9488644", "7770916", "11395412", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.", "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mecha...

[ 1991, 1998, 1995, 2001, 2003, 2002, 2010, 2010, 2007, 2007 ]

10

[]

0

null

[ "Archaea", "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 94, 11093, 34, 24 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 7, 7, 14, 5, 2, 2, 10, 1, 1, 19 ]

12

true

Domain

DNA topoisomerase I, eukaryotic-type

TopoI_euk

4

IPR013500

13,500

DNA topoisomerase I, catalytic core, eukaryotic-type

TopoI_cat_euk

Domain

18,452

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003917", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "CDD" ]

[ "PF01028", "cd00659" ]

[ "Topoisom_I", "Topo_IB_C" ]

[ 18448, 7515 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.1", "R-CEL-4615885", "R-DDI-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885" ]

[ "EC:5.6.2.1", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-HSA-4615885", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615885" ]

8

[ "1a31", "1a35", "1a36", "1a41", "1ej9", "1k4s", "1k4t", "1lpq", "1nh3", "1r49", "1rr8", "1rrj", "1sc7", "1seu", "1t8i", "1tl8", "2b9s", "2f4q", "2h7f", "2h7g", "3igc", "3m4a", "6z01", "6z03" ]

24

[ "PUB00004398", "PUB00005230", "PUB00005437", "PUB00006312", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "1849260", "9488644", "7770916", "7994576", "11395412", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites.", "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "Crystal structure of the amino-terminal fragment o...

[ 1991, 1998, 1995, 1994, 2001, 2003, 2002, 2010, 2010, 2007, 2007 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 100, 6945, 11122, 200, 85 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 7, 7, 13, 5, 2, 2, 10, 1, 1, 20 ]

12

true

Domain

DNA topoisomerase I, catalytic core, eukaryotic-type

TopoI_cat_euk

3

IPR013501

13,501

Ethanolamine utilization microcompartment shell protein, Lmo1185-like

Lmo1185-like

Family

46

false

This entry represents a family of proteins from firmicutes, including Lmo1185 from Listeria monocytogenes ( ). Members are trimeric shell proteins encoded in ethanolamine utilization microcompartment operons [ ]. This family is closely related to the PduT protein encoded in propane-diol operons.

[]

0

[ "NCBIFAM" ]

[ "TIGR02526" ]

[ "eut_PduT" ]

[ 46 ]

1

[ "GP" ]

[ "GenProp0292" ]

[ "GP:GenProp0292" ]

1

[]

0

[ "PUB00106006" ]

[ "33850044" ]

[ "Bacterial Microcompartments Coupled with Extracellular Electron Transfer Drive the Anaerobic Utilization of Ethanolamine in Listeria monocytogenes." ]

[ 2021 ]

1

[ "IPR011238" ]

[]

1

0

1

[ "Bacillota" ]

[ 46 ]

1

[]

0

true

Family

Ethanolamine utilization microcompartment shell protein, Lmo1185-like

Lmo1185-like

7

IPR013502

13,502

Uncharacterised protein AF0941

Uncharacterised_AF0941

Family

94

false

This entry represents the hypothetical protein AF_0941 from the hyperthermophilic sulphate-reducing archaeon Archaeoglobus fulgidus. The structure of this protein consists of several α-helices arranged in an orthogonal bundle.

[]

0

[ "PFAM" ]

[ "PF14591" ]

[ "AF0941-like" ]

[ 94 ]

1

[]

0

[ "1yoz" ]

1

[]

0

[]

0

null

[ "Archaeoglobus", "Campylobacterales", "Hibiscus sabdariffa", "Terrestrivirus sp.", "metagenomes" ]

[ 10, 65, 1, 1, 17 ]

5

[]

0

true

Family

Uncharacterised protein AF0941

Uncharacterised_AF0941

9

IPR013503

13,503

Circadian clock KaiC, bacteria

Circadian_KaiC_bact

Family

544

false

The circadian clock protein KaiC, is encoded in the kaiABC operon that forms the KaiABC oscillator complex which controls circadian rhythms and may be universal in Cyanobacteria [ , , ]. Each member contains two copies of the KaiC domain, which is also found in other proteins. KaiC performs autophosphorylation and acts...

[ "GO:0000287", "GO:0003677", "GO:0004674", "GO:0005524", "GO:0006355", "GO:0042752" ]

[ "magnesium ion binding", "DNA binding", "protein serine/threonine kinase activity", "ATP binding", "regulation of DNA-templated transcription", "regulation of circadian rhythm" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

6

[ "HAMAP", "NCBIFAM" ]

[ "MF_01836", "TIGR02655" ]

[ "KaiC", "circ_KaiC" ]

[ 365, 544 ]

2

[ "EC", "EC", "GP", "METACYC" ]

[ "2.7.11.1", "3.6.4.-", "GenProp0465", "PWY-7250" ]

[ "EC:2.7.11.1", "EC:3.6.4.-", "GP:GenProp0465", "METACYC:PWY-7250" ]

4

[ "1tf7", "1u9i", "2gbl", "3dvl", "3jzm", "3k09", "3k0a", "3k0c", "3k0e", "3k0f", "3s1a", "4dug", "4ijm", "4o0m", "5jwq", "5n8y", "7dxq", "7dy1", "7dy2", "7dye", "7dyi", "7dyj", "7dyk", "7s65", "7s66", "7s67", "7v3x", "7wdc", "7x1y", "7x1z", "8jon", "8wv8"...

39

[ "PUB00033187", "PUB00103592", "PUB00103593", "PUB00103606" ]

[ "16628225", "25139948", "31767776", "23449916" ]

[ "Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods.", "Deletion of the Synechocystis sp. PCC 6803 kaiAB1C1 gene cluster causes impaired cell growth under light-dark conditions.", "Synechocystis KaiC3 Displays Temperature- and KaiB-Dependent ATPase ...

[ 2006, 2014, 2020, 2013 ]

4

[ "IPR030665" ]

[]

1

0

1

[ "Bacteria", "metagenome" ]

[ 542, 2 ]

2

[]

0

true

Family

Circadian clock KaiC, bacteria

Circadian_KaiC_bact

3

IPR013504

13,504

Methylamine/Aralkylamine dehydrogenase light chain, C-terminal domain

MADH/AADH_Ltc_C_dom

Domain

795

false

Aralkylamine dehydrogenase light chain and methylamine dehydrogenase light chain are aromatic amine dehydrogenases that form heterotetramers with their respective heavy chains, and catalyse the oxidative deamination of amines to their corresponding aldehydes. This entry represents a conserved domain found towards the C...

[ "GO:0016638", "GO:0009308", "GO:0042597" ]

[ "oxidoreductase activity, acting on the CH-NH2 group of donors", "amine metabolic process", "periplasmic space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF02975" ]

[ "Me-amine-dh_L" ]

[ 795 ]

1

[ "EC", "METACYC" ]

[ "1.4.9.1", "PWY-6967" ]

[ "EC:1.4.9.1", "METACYC:PWY-6967" ]

2

[ "1mae", "1maf", "1mda", "1mg2", "1mg3", "2agl", "2agw", "2agx", "2agy", "2agz", "2ah0", "2ah1", "2bbk", "2gc4", "2gc7", "2h3x", "2h47", "2hj4", "2hjb", "2hkm", "2hkr", "2hxc", "2i0r", "2i0s", "2i0t", "2iaa", "2iup", "2iuq", "2iur", "2iuv", "2j55", "2j56"...

69

[]

0

[]

0

null

[ "Bacteria", "Steinernema glaseri", "unclassified sequences" ]

[ 777, 1, 17 ]

3

[]

0

true

Domain

Methylamine/Aralkylamine dehydrogenase light chain, C-terminal domain

MADH/AADH_Ltc_C_dom

7

IPR013506

13,506

DNA topoisomerase, type IIA, subunit B, domain 2

Topo_IIA_bsu_dom2

Domain

76,528

false

Type IIA topoisomerases together manage chromosome integrity and topology in cells. Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, t...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PFAM" ]

[ "PF00204" ]

[ "DNA_gyraseB" ]

[ 76528 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.2", "R-CEL-4615885", "R-DDI-4615885", "R-DME-4615885", "R-HSA-1362277", "R-HSA-4615885", "R-HSA-9638771", "R-HSA-9913143", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885", "R-SSC-4615885" ]

[ "EC:5.6.2.2", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-DME-4615885", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-4615885", "REACTOME:R-HSA-9638771", "REACTOME:R-HSA-9913143", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615...

13

[ "1ei1", "1kij", "1pvg", "1qzr", "1s16", "1zxm", "1zxn", "3cwv", "3lnu", "3lps", "3zkb", "3zkd", "3zm7", "4gfh", "4hxz", "4hy1", "4hym", "4i3h", "4juo", "4kqv", "4prv", "4prx", "4pu9", "4r1f", "4url", "4wub", "4wuc", "4wud", "4xtj", "4zvi", "5j5p", "5j5q"...

86

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020802", "PUB00020803" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "16023670", "8982450" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "The structural basis for substrate...

[ 1995, 2001, 2003, 2002, 1994, 2005, 1996 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 588, 65061, 9062, 660, 1157 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 21, 3, 5, 1, 2, 8, 5, 2, 8, 7, 1, 1, 57 ]

13

true

Domain

DNA topoisomerase, type IIA, subunit B, domain 2

Topo_IIA_bsu_dom2

1

IPR013507

13,507

DNA mismatch repair protein, S5 domain 2-like

DNA_mismatch_S5_2-like

Domain

37,234

false

This domain is found in MutL and homologues and is characterised by a ribosomal protein S5 domain 2-like fold [ ]. The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF01119", "SM01340" ]

[ "DNA_mis_repair", "DNA_mis_repair" ]

[ 35450, 36954 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-5358565", "R-GGA-5358565", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5545483", "R-HSA-5632987", "R-HSA-6796648", "R-HSA-912446", "R-MMU-5358565", "R-RNO-5358565", "R-SCE-5358565", "R-SPO-5358565" ]

[ "REACTOME:R-DDI-5358565", "REACTOME:R-GGA-5358565", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5545483", "REACTOME:R-HSA-5632987", "REACTOME:R-HSA-6796648", "REACTOME:R-HSA-912446", "REACTOME:R-MMU-5358565", "REACTOME:R-RNO-5358565", "REACTOME:R-SCE-5358565", "REACTOME...

12

[ "1b62", "1b63", "1bkn", "1ea6", "1h7s", "1h7u", "1nhh", "1nhi", "1nhj", "3h4l", "4p7a", "5akb", "5akc", "5akd", "5x9y", "6lzi", "6lzj", "6lzk", "6mfq", "7aib", "7aic", "7p8v", "7rcb", "7rci", "7rck" ]

25

[ "PUB00020815", "PUB00088626" ]

[ "14527292", "26249686" ]

[ "DNA mismatch repair: molecular mechanisms and biological function.", "Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome." ]

[ 2003, 2015 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 638, 20379, 15927, 290 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 21, 2, 20, 7, 1, 55, 15, 3, 8, 21, 4, 2, 21 ]

13

true

Domain

DNA mismatch repair protein, S5 domain 2-like

DNA_mismatch_S5_2-like

8

IPR013509

13,509

Ribonucleotide reductase large subunit, N-terminal

RNR_lsu_N

Domain

38,150

false

Ribonucleotide reductase (RNR, ) [ , ] catalyses the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs divide into three classes on the basis of their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, bact...

[ "GO:0004748", "GO:0005524", "GO:0009263" ]

[ "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "ATP binding", "deoxyribonucleotide biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF00317" ]

[ "Ribonuc_red_lgN" ]

[ 38150 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.17.4.1", "PWY-6545", "PWY-7184", "PWY-7198", "PWY-7210", "PWY-7220", "PWY-7222", "PWY-7226", "PWY-7227", "R-CEL-499943", "R-DDI-499943", "R-DME-499943", "R-DRE-499943", "R-HSA-499943", "R-HSA-5213460", "R-HSA-9686347", "R-MMU-499943", "R-SCE-499943", "R-SPO-499943" ]

[ "EC:1.17.4.1", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7198", "METACYC:PWY-7210", "METACYC:PWY-7220", "METACYC:PWY-7222", "METACYC:PWY-7226", "METACYC:PWY-7227", "REACTOME:R-CEL-499943", "REACTOME:R-DDI-499943", "REACTOME:R-DME-499943", "REACTOME:R-DRE-499943", "REACTOME:R-HSA...

19

[ "1pem", "1peo", "1peq", "1peu", "1r1r", "1rlr", "1xje", "1xjf", "1xjg", "1xjj", "1xjk", "1xjm", "1xjn", "1zyz", "1zzd", "2bq1", "2cvs", "2cvt", "2cvu", "2cvv", "2cvw", "2cvx", "2cvy", "2eud", "2r1r", "2wgh", "2x0x", "2xak", "2xap", "2xav", "2xaw", "2xax"...

139

[ "PUB00000559", "PUB00005164", "PUB00005953", "PUB00005954", "PUB00007088" ]

[ "3286319", "8511586", "9309223", "8052308", "11875520" ]

[ "Structure-function studies of the large subunit of ribonucleotide reductase from Escherichia coli.", "From RNA to DNA, why so many ribonucleotide reductases?", "Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding.", "Structure ...

[ 1988, 1993, 1997, 1994, 2002 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 893, 27571, 6498, 2526, 662 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 1, 2, 1, 2, 6, 3, 1, 5, 4, 2, 1, 5 ]

13

true

Domain

Ribonucleotide reductase large subunit, N-terminal

RNR_lsu_N

3

IPR013512

13,512

1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal

DXP_reductoisomerase_N

Domain

23,209

false

This domain is found at the N terminus of bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases. It is responsible for the binding to NADPH [ ]. 1-deoxy-D-xylulose 5-phosphate reductoisomerase synthesises 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose 5-phosphate in a single step by intramol...

[ "GO:0070402" ]

[ "NADPH binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02670" ]

[ "DXP_reductoisom" ]

[ 23209 ]

1

[ "EC", "METACYC" ]

[ "1.1.1.267", "PWY-7560" ]

[ "EC:1.1.1.267", "METACYC:PWY-7560" ]

2

[ "1jvs", "1k5h", "1onn", "1ono", "1onp", "1q0h", "1q0l", "1q0q", "1r0k", "1r0l", "1t1r", "1t1s", "2c82", "2egh", "2jcv", "2jcx", "2jcy", "2jd0", "2jd1", "2jd2", "2y1c", "2y1d", "2y1e", "2y1f", "2y1g", "3a06", "3a14", "3anl", "3anm", "3ann", "3au8", "3au9"...

88

[ "PUB00020977", "PUB00099840", "PUB00099841" ]

[ "9707569", "24998420", "30278288" ]

[ "A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis.", "Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.", "Structural characterization of 1-deoxy-D-xylul...

[ 1998, 2014, 2018 ]

3

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "unclassified sequences" ]

[ 21309, 2, 1353, 545 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 1, 11 ]

4

true

Domain

1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal

DXP_reductoisomerase_N

8

IPR013514

13,514

Protein of unknown function DUF3199, YqbG

DUF3199_YqbG

Family

322

false

This entry represents the hypothetical protein YqbG from Bacillus species, as well as related proteins from other bacteria. YqbG exists as a monomer, consisting of four α-helices with a right-handed twist, arranged in a left-handed superhelix [ ].

[]

0

[ "NCBIFAM", "PFAM", "CDD" ]

[ "NF050002", "PF11436", "cd08053" ]

[ "YqbG", "DUF3199", "Yqbg" ]

[ 132, 144, 302 ]

3

[]

0

[ "1xn8", "1zts" ]

2

[ "PUB00035945" ]

[ "16281282" ]

[ "NMR structure of protein yqbG from Bacillus subtilis reveals a novel alpha-helical protein fold." ]

[ 2006 ]

1

[]

0

null

[ "Bacillati", "Viruses" ]

[ 281, 41 ]

2

[]

0

true

Family

Protein of unknown function DUF3199, YqbG

DUF3199_YqbG

2

IPR013516

13,516

Phytochrome chromophore binding site

Phyto_chromo_BS

Binding_site

10,495

false

Phytochrome [ , , ] is a plant protein that acts as a regulatory photoreceptor and which mediates red-light effects on a wide variety of physiological and molecular responses. Phytochrome can undergo a reversible photochemical conversion between a biologically inactive red light-absorbing form and the active far-red li...

[]

0

[ "PROSITE" ]

[ "PS00245" ]

[ "PHYTOCHROME_1" ]

[ 10495 ]

1

[ "PROSITEDOC" ]

[ "PDOC00218" ]

[ "PROSITEDOC:PDOC00218" ]

1

[ "4our", "6tby", "6tc5", "6tc7", "6tl4", "7rzw", "8f5z", "8iff", "8isi", "8isj", "8isk", "8r44", "8r45", "8yb4", "9er4", "9f4i", "9irk", "9itf", "9iuz", "9jlb", "9qzt" ]

21

[ "PUB00000104", "PUB00000736", "PUB00097030" ]

[ "1812812", "9230690", "27789797" ]

[ "Phytochrome: a light-activated molecular switch that regulates plant gene expression.", "The phytochromes: a biochemical mechanism of signaling in sight?", "Phytochromes function as thermosensors in Arabidopsis." ]

[ 1991, 1997, 2016 ]

3

[]

0

null

[ "Bifidobacterium pseudolongum subsp. globosum", "Eukaryota" ]

[ 1, 10494 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 74, 35, 18 ]

3

true

Binding_site

Phytochrome chromophore binding site

Phyto_chromo_BS

6

IPR013518

13,518

Potassium channel, inwardly rectifying, Kir, cytoplasmic

K_chnl_inward-rec_Kir_cyto

Homologous_superfamily

21,842

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.40.1400" ]

[ "" ]

[ 21842 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1296041", "R-BTA-1296053", "R-BTA-5576886", "R-BTA-997272", "R-CEL-1296041", "R-CEL-1296053", "R-CEL-1296067", "R-CEL-5576886", "R-CEL-997272", "R-CFA-1296041", "R-CFA-1296053", "R-CFA-5576886", "R-CFA-997272", "R-GGA-1296041", "R-GGA-1296053", "R-GGA-5576886", "R-GGA-997272",...

[ "REACTOME:R-BTA-1296041", "REACTOME:R-BTA-1296053", "REACTOME:R-BTA-5576886", "REACTOME:R-BTA-997272", "REACTOME:R-CEL-1296041", "REACTOME:R-CEL-1296053", "REACTOME:R-CEL-1296067", "REACTOME:R-CEL-5576886", "REACTOME:R-CEL-997272", "REACTOME:R-CFA-1296041", "REACTOME:R-CFA-1296053", "REACTOME:...

51

[ "1n9p", "1p7b", "1u4e", "1u4f", "1xl4", "1xl6", "2e4f", "2gix", "2qks", "2wlh", "2wli", "2wlj", "2wlk", "2wll", "2wlm", "2wln", "2wlo", "2x6a", "2x6b", "2x6c", "2xky", "3agw", "3at8", "3at9", "3ata", "3atb", "3atd", "3ate", "3atf", "3auw", "3jyc", "3k6n"...

110

[ "PUB00001055", "PUB00001069", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00009378", "PUB00009410", "PUB00009411" ]

[ "1772658", "7580148", "1879548", "1373731", "2448635", "2451788", "2555158", "11178249", "10102275", "10449331" ]

[ "The molecular biology of K+ channels.", "The inward rectifier potassium channel family.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced ...

[ 1991, 1995, 1991, 1992, 1988, 1988, 1989, 2000, 1999, 1999 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1604, 20225, 13 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 49, 19, 52, 55, 70 ]

6

true

Homologous_superfamily

Potassium channel, inwardly rectifying, Kir, cytoplasmic

K_chnl_inward-rec_Kir_cyto

8

IPR013519

13,519

Integrin alpha beta-propellor

Int_alpha_beta-p

Repeat

36,417

false

Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a β-propeller fold. Some of these domains contain an inserted von Willebrand factor ...

[]

0

[ "PROFILE", "SMART" ]

[ "PS51470", "SM00191" ]

[ "FG_GAP", "Int_alpha" ]

[ 33102, 35345 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1566948", "R-BTA-1566977", "R-BTA-198933", "R-BTA-202733", "R-BTA-210991", "R-BTA-216083", "R-BTA-3000157", "R-BTA-6798695", "R-BTA-8874081", "R-BTA-9634597", "R-BTA-9860927", "R-CEL-114608", "R-CEL-1236973", "R-CEL-1566977", "R-CEL-198933", "R-CEL-202733", "R-CEL-210991", "...

[ "REACTOME:R-BTA-1566948", "REACTOME:R-BTA-1566977", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-202733", "REACTOME:R-BTA-210991", "REACTOME:R-BTA-216083", "REACTOME:R-BTA-3000157", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8874081", "REACTOME:R-BTA-9634597", "REACTOME:R-BTA-9860927", "REACTOME:R-...

133

[ "1jv2", "1l5g", "1m1x", "1tye", "1u8c", "2vc2", "2vdk", "2vdl", "2vdm", "2vdn", "2vdo", "2vdp", "2vdq", "2vdr", "3fcs", "3fcu", "3ije", "3k6s", "3k71", "3k72", "3nid", "3nif", "3nig", "3t3m", "3t3p", "3v4p", "3v4v", "3vi3", "3vi4", "3zdx", "3zdy", "3zdz"...

159

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 130, 8038, 28086, 31, 132 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 64, 10, 86, 98, 93, 1 ]

7

true

Repeat

Integrin alpha beta-propellor

Int_alpha_beta-p

7

IPR013520

13,520

Ribonuclease H-like domain

Ribonucl_H

Domain

133,773

false

This entry includes a variety of exonuclease proteins, such as Oligoribonuclease, ribonuclease T [ ] and the epsilon subunit of DNA polymerase III. Ribonuclease T ( ) is an enzyme found so far only in gamma-subdivision proteobacteria such as Escherichia coli and Xylella fastidiosa. Ribonuclease T is homologous to the D...

[]

0

[ "PFAM", "SMART" ]

[ "PF00929", "SM00479" ]

[ "RNase_T", "EXOIII" ]

[ 124752, 128142 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-GGA-429947", "R-HSA-3248023", "R-HSA-3270619", "R-HSA-429947", "R-HSA-6791226", "R-HSA-909733", "R-HSA-9836573", "R-MMU-429947", "R-MMU-6791226", "R-RNO-429947", "R-RNO-6791226", "R-SCE-429947" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-GGA-429947", "REACTOME:R-HSA-3248023", "REACTOME:R-HSA-3270619", "REACTOME:R-HSA-429947", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9836573", "REACTOME:R-MMU-429947", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-429947", "REACTOME:R-R...

13

[ "1fxx", "1j53", "1j54", "1j9a", "1w0h", "1wlj", "1y97", "1yta", "1zbh", "1zbu", "2f96", "2gbz", "2gui", "2ido", "2igi", "2ioc", "2is3", "2o4g", "2o4i", "2oa8", "2p1j", "2qxf", "2xri", "2xy8", "3b6o", "3b6p", "3c94", "3c95", "3cg7", "3cm5", "3cm6", "3hl8"...

163

[ "PUB00004421", "PUB00017662", "PUB00053942", "PUB00121666", "PUB00160781" ]

[ "8506149", "9857048", "9573169", "10200269", "26305928" ]

[ "RNase T shares conserved sequence motifs with DNA proofreading exonucleases.", "Identification of a potent DNase activity associated with RNase T of Escherichia coli.", "Oligoribonuclease is encoded by a highly conserved gene in the 3'-5' exonuclease superfamily.", "Oligoribonuclease is an essential componen...

[ 1993, 1998, 1998, 1999, 2015 ]

5

[]

[ "IPR006054", "IPR034922", "IPR037431", "IPR037433", "IPR047201" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 147, 90392, 41007, 642, 2, 1583 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 77, 13, 20, 18, 9, 53, 47, 7, 51, 57, 5, 6, 79 ]

13

true

Domain

Ribonuclease H-like domain

Ribonucl_H

8

IPR013523

13,523

Histone acetyltransferase HAT1, C-terminal

Hist_AcTrfase_HAT1_C

Homologous_superfamily

2,881

false

Histone acetylation is carried out by a class of enzymes known as histone acetyltransferases (HATs), which catalyse the transfer of an acetyl group from acetyl-CoA to the lysine E -amino groups on the N-terminal tails of histones [ , ]. Early indication that HATs were involved in transcription came from the observation...

[ "GO:0042393" ]

[ "histone binding" ]

[ "molecular_function" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.10.390" ]

[ "" ]

[ 2881 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1.48", "R-HSA-3214847", "R-MMU-3214847", "R-RNO-3214847", "R-SCE-3214847", "R-SPO-3214847" ]

[ "EC:2.3.1.48", "REACTOME:R-HSA-3214847", "REACTOME:R-MMU-3214847", "REACTOME:R-RNO-3214847", "REACTOME:R-SCE-3214847", "REACTOME:R-SPO-3214847" ]

6

[ "1bob", "2p0w", "4psw", "4psx", "6vo5", "7xay", "9mjg" ]

7

[ "PUB00005463", "PUB00006420", "PUB00006453", "PUB00011790", "PUB00097474" ]

[ "9175471", "9727486", "10430873", "12801725", "22615379" ]

[ "GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.", "Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.", "Crystal structure and mechanism of histone acetylation of the yeast GCN5 trans...

[ 1997, 1998, 1999, 2003, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2881 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 2, 2, 2, 1, 6, 1, 1 ]

9

true

Homologous_superfamily

Histone acetyltransferase HAT1, C-terminal

Hist_AcTrfase_HAT1_C

7

IPR013524

13,524

Runt domain

Runt_dom

Domain

6,209

false

null

[ "GO:0003677", "GO:0003700", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PROFILE" ]

[ "PF00853", "PS51062" ]

[ "Runt", "RUNT" ]

[ 6119, 6194 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC51062", "R-CEL-549127", "R-CEL-8877330", "R-CEL-8878166", "R-CEL-8934593", "R-CEL-8936459", "R-CEL-8939236", "R-CEL-8939243", "R-CEL-8939245", "R-CEL-8939246", "R-CEL-8939247", "R-CEL-8939902", "R-CEL-8941326", "R-CEL-8941855", "R-CEL-8941858", "R-CEL-8951430", "R-CEL-8951671", ...

[ "PROSITEDOC:PDOC51062", "REACTOME:R-CEL-549127", "REACTOME:R-CEL-8877330", "REACTOME:R-CEL-8878166", "REACTOME:R-CEL-8934593", "REACTOME:R-CEL-8936459", "REACTOME:R-CEL-8939236", "REACTOME:R-CEL-8939243", "REACTOME:R-CEL-8939245", "REACTOME:R-CEL-8939246", "REACTOME:R-CEL-8939247", "REACTOME:R...

104

[ "1cmo", "1co1", "1e50", "1ean", "1eao", "1eaq", "1h9d", "1hjb", "1hjc", "1io4", "1ljm", "2j6w", "3wts", "3wtt", "3wtu", "3wtv", "3wtw", "3wtx", "3wty", "3wu1", "4l0y", "4l0z", "4l18", "6vg8", "6vgd", "6vge", "6vgg" ]

27

[ "PUB00004459" ]

[ "7651838" ]

[ "Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 3, 37, 6168, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 62, 12, 24, 18, 21 ]

6

true

Domain

Runt domain

Runt_dom

6

IPR013525

13,525

ABC-2 type transporter, transmembrane domain

ABC2_TM

Domain

272,530

false

ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) [ ]. But...

[ "GO:0140359", "GO:0016020" ]

[ "ABC-type transporter activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PFAM" ]

[ "PF01061", "PF12698" ]

[ "ABC2_membrane", "ABC2_membrane_3" ]

[ 171094, 101975 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp1398", "GenProp1756", "R-BTA-2453902", "R-BTA-382556", "R-DDI-1369062", "R-DDI-1660661", "R-DDI-189451", "R-DDI-189483", "R-DDI-2453902", "R-DDI-382556", "R-DDI-5683826", "R-DDI-6798695", "R-DDI-8963896", "R-DDI-8964058", "R-DDI-917937", "R-DDI-9753281", "R-DDI-9793528", "R...

[ "GP:GenProp1398", "GP:GenProp1756", "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-382556", "REACTOME:R-DDI-1369062", "REACTOME:R-DDI-1660661", "REACTOME:R-DDI-189451", "REACTOME:R-DDI-189483", "REACTOME:R-DDI-2453902", "REACTOME:R-DDI-382556", "REACTOME:R-DDI-5683826", "REACTOME:R-DDI-6798695", ...

86

[ "3cni", "5do7", "5nj3", "5njg", "5xjy", "6eti", "6feq", "6ffc", "6hbu", "6hco", "6hij", "6hzm", "6jbh", "6m96", "6oih", "6vxf", "6vxh", "6vxi", "6vxj", "7e7i", "7e7o", "7e7q", "7fdv", "7jr7", "7k2t", "7lkp", "7lkz", "7m1p", "7m1q", "7neq", "7nez", "7nfd"...

120

[ "PUB00003808", "PUB00004290", "PUB00004998", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "1659649", "9872322", "1303751", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270" ]

[ "Evidence for a common molecular origin of the capsule gene loci in gram-negative bacteria expressing group II capsular polysaccharides.", "Crystal structure of the ATP-binding subunit of an ABC transporter.", "A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates....

[ 1991, 1998, 1992, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001 ]

13

[]

[ "IPR047817" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3637, 158888, 107741, 9, 2255 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 239, 24, 41, 66, 5, 63, 61, 7, 158, 81, 10, 2, 423 ]

13

true

Domain

ABC-2 type transporter, transmembrane domain

ABC2_TM

2

IPR013527

13,527

Endoribonuclease YicC-like, N-terminal

YicC-like_N

Domain

15,048

false

This entry represents the N-terminal region of Endoribonuclease YicC from Escherichia coli and similar bacterial sequences. YicC has been shown to be important for cells in the stationary phase, and essential for growth at high temperatures [ ]. This protein contributes to degradation of the small RNA (sRNA) RhyB by 3'...

[]

0

[ "PFAM" ]

[ "PF03755" ]

[ "YicC-like_N" ]

[ 15048 ]

1

[ "EC" ]

[ "3.1.26.-" ]

[ "EC:3.1.26.-" ]

1

[ "8hvj", "8ver", "8ves" ]

3

[ "PUB00020576", "PUB00151088", "PUB00151089" ]

[ "1925027", "34815358", "34210798" ]

[ "Three genes preceding pyrE on the Escherichia coli chromosome are essential for survival and normal cell morphology in stationary culture and at high temperature.", "Discovery and initial characterization of YloC, a novel endoribonuclease in <i>Bacillus subtilis</i>.", "A fluorescence-based genetic screen reve...

[ 1991, 2022, 2021 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14757, 31, 260 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Endoribonuclease YicC-like, N-terminal

YicC-like_N

3

IPR013529

13,529

Glycoside hydrolase, family 42, N-terminal

Glyco_hydro_42_N

Domain

16,742

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0004565", "GO:0005975", "GO:0009341" ]

[ "beta-galactosidase activity", "carbohydrate metabolic process", "beta-galactosidase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF02449" ]

[ "Glyco_hydro_42" ]

[ 16742 ]

1

[ "EC", "GP", "METACYC" ]

[ "3.2.1.23", "GenProp1522", "PWY-6807" ]

[ "EC:3.2.1.23", "GP:GenProp1522", "METACYC:PWY-6807" ]

3

[ "1kwg", "1kwk", "3tts", "3tty", "3u7v", "4bq2", "4bq3", "4bq4", "4bq5", "4d1i", "4d1j", "4oif", "4ucf", "4uni", "4uoq", "4uoz", "4uzs", "5dfa", "5e9a", "5gsl", "5gsm", "5jaw", "5xb7", "5z6p", "6jow", "6lvw", "6ptm", "6tbf", "6tbg", "6tbh", "6tbi", "6tbj"...

43

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 133, 15559, 953, 97 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Glycoside hydrolase, family 42, N-terminal

Glyco_hydro_42_N

4

IPR013530

13,530

Protein-arginine deiminase, C-terminal

PAD_C

Domain

4,231

false

This domain is found at the C-terminal end of protein-arginine deiminases. In the presence of calcium ions, Protein-arginine deiminase (PAD) enzymes catalyse the post-translational modification reaction responsible for the formation of citrulline residues from protein-bound arginine residues [ ]. Four PAD isotypes of P...

[ "GO:0004668", "GO:0005509", "GO:0005737" ]

[ "protein-arginine deiminase activity", "calcium ion binding", "cytoplasm" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM" ]

[ "PF03068" ]

[ "PAD" ]

[ 4231 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.3.15", "PWY-4921", "R-HSA-3247509", "R-HSA-6798695", "R-MMU-3247509", "R-MMU-6798695", "R-RNO-3247509", "R-RNO-6798695" ]

[ "EC:3.5.3.15", "METACYC:PWY-4921", "REACTOME:R-HSA-3247509", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-3247509", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-3247509", "REACTOME:R-RNO-6798695" ]

8

[ "1wd8", "1wd9", "1wda", "2dew", "2dex", "2dey", "2dw5", "3apm", "3apn", "3b1t", "3b1u", "4dkt", "4n20", "4n22", "4n24", "4n25", "4n26", "4n28", "4n2a", "4n2b", "4n2c", "4n2d", "4n2e", "4n2f", "4n2g", "4n2h", "4n2i", "4n2k", "4n2l", "4n2m", "4n2n", "4x8c"...

62

[ "PUB00007480", "PUB00100949", "PUB00100950", "PUB00100951" ]

[ "10092850", "27545678", "28549415", "30044909" ]

[ "Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.", "Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.", "Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration....

[ 1999, 2016, 2017, 2018 ]

4

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 471, 3756, 4 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 11, 11, 20 ]

4

true

Domain

Protein-arginine deiminase, C-terminal

PAD_C

8

IPR013531

13,531

Pro-opiomelanocortin/corticotropin, ACTH, central region

Mcrtin_ACTH_cent

Domain

5,571

false

Pro-opiomelanocortin is present in high levels in the pituitary and is processed into 3 major peptide families: adrenocorticotrophin (ACTH); alpha-, beta- and gamma-melanocyte- stimulating hormones (MSH); and beta-endorphin [ ]. ACTH regulates the synthesis and release of glucocorticoids and, to some extent, aldosteron...

[]

0

[ "PFAM", "SMART" ]

[ "PF00976", "SM01363" ]

[ "ACTH_domain", "ACTH_domain" ]

[ 5553, 5386 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111885", "R-BTA-193048", "R-BTA-194002", "R-BTA-202040", "R-BTA-209952", "R-BTA-211976", "R-BTA-375276", "R-BTA-418555", "R-BTA-418594", "R-HSA-111885", "R-HSA-193048", "R-HSA-194002", "R-HSA-202040", "R-HSA-209952", "R-HSA-211976", "R-HSA-375276", "R-HSA-418555", "R-HSA-418...

[ "REACTOME:R-BTA-111885", "REACTOME:R-BTA-193048", "REACTOME:R-BTA-194002", "REACTOME:R-BTA-202040", "REACTOME:R-BTA-209952", "REACTOME:R-BTA-211976", "REACTOME:R-BTA-375276", "REACTOME:R-BTA-418555", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-111885", "REACTOME:R-HSA-193048", "REACTOME:R-HSA-194...

39

[ "7f4d", "7f53", "8gy7", "8inr", "8w8w", "8w8x" ]

6

[ "PUB00000465", "PUB00002596" ]

[ "2839146", "2266117" ]

[ "Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary.", "Post-translational modification of bovine pro-opiomelanocortin. Tyrosine sulfation and pyroglutamate formation, a mass spectrometric study." ]

[ 1988, 1990 ]

2

[]

0

null

[ "Cohnella phaseoli", "Eumetazoa" ]

[ 1, 5570 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 15, 1, 4 ]

4

true

Domain

Pro-opiomelanocortin/corticotropin, ACTH, central region

Mcrtin_ACTH_cent

7

IPR013532

13,532

Opiodes neuropeptide

Opioid_neuropept

Domain

2,456

false

Pro-opiomelanocortin is present in high levels in the pituitary and is processed into 3 major peptide families: adrenocorticotrophin (ACTH); alpha-, beta- and gamma-melanocyte- stimulating hormones (MSH); and beta-endorphin [ ]. ACTH regulates the synthesis and release of glucocorticoids and, to some extent, aldosteron...

[]

0

[ "PFAM", "SMART" ]

[ "PF08035", "SM01365" ]

[ "Op_neuropeptide", "Op_neuropeptide" ]

[ 2451, 1934 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111885", "R-BTA-193048", "R-BTA-194002", "R-BTA-202040", "R-BTA-209952", "R-BTA-211976", "R-BTA-375276", "R-BTA-418555", "R-BTA-418594", "R-HSA-111885", "R-HSA-193048", "R-HSA-194002", "R-HSA-202040", "R-HSA-209952", "R-HSA-211976", "R-HSA-375276", "R-HSA-418555", "R-HSA-418...

[ "REACTOME:R-BTA-111885", "REACTOME:R-BTA-193048", "REACTOME:R-BTA-194002", "REACTOME:R-BTA-202040", "REACTOME:R-BTA-209952", "REACTOME:R-BTA-211976", "REACTOME:R-BTA-375276", "REACTOME:R-BTA-418555", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-111885", "REACTOME:R-HSA-193048", "REACTOME:R-HSA-194...

39

[ "6tub", "8f7q" ]

2

[ "PUB00000465", "PUB00002596" ]

[ "2839146", "2266117" ]

[ "Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary.", "Post-translational modification of bovine pro-opiomelanocortin. Tyrosine sulfation and pyroglutamate formation, a mass spectrometric study." ]

[ 1988, 1990 ]

2

[]

0

null

[ "Vertebrata" ]

[ 2456 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 12, 1, 4 ]

4

true

Domain

Opiodes neuropeptide

Opioid_neuropept

7

IPR013534

13,534

Starch synthase, catalytic domain

Starch_synth_cat_dom

Domain

30,124

false

This region represents the catalytic domain of glycogen (or starch) synthases that use ADP-glucose ( ), rather than UDP-glucose ( ) as in animals, as the glucose donor. This enzyme is found in bacteria and plants. Whether the name given is glycogen synthase or starch synthase depends on context, and therefore on substr...

[]

0

[ "PFAM" ]

[ "PF08323" ]

[ "Glyco_transf_5" ]

[ 30124 ]

1

[ "EC", "EC", "METACYC" ]

[ "2.4.1", "2.4.1.21", "PWY-622" ]

[ "EC:2.4.1", "EC:2.4.1.21", "METACYC:PWY-622" ]

3

[ "1rzu", "1rzv", "2bis", "2qzs", "2r4t", "2r4u", "3cop", "3cx4", "3d1j", "3fro", "3guh", "3l01", "3vue", "3vuf", "4hln", "6gne", "6gnf", "6gng" ]

18

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 186, 16834, 12861, 2, 241 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 39, 1, 2, 83, 5, 124 ]

6

true

Domain

Starch synthase, catalytic domain

Starch_synth_cat_dom

1

IPR013535

13,535

PUL domain

PUL_dom

Domain

6,546

false

The PUL (after PLAP, UFD3 and lub1) domain is a predicted predominantly α helical globular domain found in eukaryotes. It is found in association with either WD repeats (see ) and the PFU domain (see ) or PPPDE and thioredoxin (see ) domains. The PUL domain is a protein-protein interaction domain [ , ]. Some proteins k...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08324", "PS51396" ]

[ "PUL", "PUL" ]

[ 6480, 6337 ]

2

[]

0

[ "3ebb", "3gae", "3l3f", "3psp", "3pst", "5h7c" ]

6

[ "PUB00020916", "PUB00035448" ]

[ "15483401", "16428438" ]

[ "Novel predicted peptidases with a potential role in the ubiquitin signaling pathway.", "Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain." ]

[ 2004, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacterium formicicum (strain DSM 3637 / PP1)" ]

[ 27, 6518, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 1, 2, 4, 2, 2, 4, 5, 1, 1, 12 ]

12

true

Domain

PUL domain

PUL_dom

8

IPR013536

13,536

WLM domain

WLM_dom

Domain

6,546

false

The WLM (WSS1-like metalloprotease) domain is a globular domain related to the zincin-like superfamily of Zn-dependent peptidase. Since the WLM domain contains all known active site residues of zincins, it is predicted to be a catalytically active peptidase domain. The WLM domain is a eukaryotic domain represented in p...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08325", "PS51397" ]

[ "WLM", "WLM" ]

[ 6508, 6303 ]

2

[ "EC", "METACYC" ]

[ "3.4.24.-", "PWY-8119" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119" ]

2

[ "5jig", "5ln5", "5xbn", "5xbv" ]

4

[ "PUB00020916", "PUB00095664" ]

[ "15483401", "24998930" ]

[ "Novel predicted peptidases with a potential role in the ubiquitin signaling pathway.", "A DNA-dependent protease involved in DNA-protein crosslink repair." ]

[ 2004, 2014 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3, 6, 6374, 36, 127 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 15, 3, 6, 1, 2, 11 ]

6

true

Domain

WLM domain

WLM_dom

9

IPR013537

13,537

Acetyl-CoA carboxylase, central domain

AcCoA_COase_cen

Domain

9,866

false

This region is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain. Enzymes containing this domain ( ) are involved in the synthesis of long-chain fatty acids, as they catalyses the rate limiting step in this process.

[ "GO:0003989", "GO:0005524", "GO:0006633" ]

[ "acetyl-CoA carboxylase activity", "ATP binding", "fatty acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF08326" ]

[ "ACC_central" ]

[ 9866 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME",...

[ "6.3.4.14", "6.4.1.2", "PWY-5743", "PWY-5744", "PWY-5789", "PWY-5966", "PWY-6679", "R-DDI-196780", "R-DDI-200425", "R-DDI-75105", "R-HSA-163765", "R-HSA-196780", "R-HSA-200425", "R-HSA-2426168", "R-HSA-3371599", "R-HSA-75105", "R-MMU-196780", "R-MMU-200425", "R-MMU-75105", "R-R...

[ "EC:6.3.4.14", "EC:6.4.1.2", "METACYC:PWY-5743", "METACYC:PWY-5744", "METACYC:PWY-5789", "METACYC:PWY-5966", "METACYC:PWY-6679", "REACTOME:R-DDI-196780", "REACTOME:R-DDI-200425", "REACTOME:R-DDI-75105", "REACTOME:R-HSA-163765", "REACTOME:R-HSA-196780", "REACTOME:R-HSA-200425", "REACTOME:R-...

28

[ "1od2", "1od4", "5cs0", "5cs4", "5csa", "5csk", "5csl", "5i6e", "5i6f", "5i6g", "5i6h", "5i6i", "5trc", "6g2d", "6g2h", "6g2i", "8xkz", "8xl0", "8xl1", "8xl2" ]

20

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenome" ]

[ 1207, 8658, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 4, 50, 3, 10, 5, 1, 2, 15, 2, 1, 142 ]

12

true

Domain

Acetyl-CoA carboxylase, central domain

AcCoA_COase_cen

5

IPR013538

13,538

Activator of Hsp90 ATPase homologue 1/2-like, C-terminal

ASHA1/2-like_C

Domain

60,446

false

This entry represents a domain found in eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90kDa heat shock protein ATPase homologue 1 (AHSA1/p38, ) and Aha1 from yeast [ , ]. This is a START-like domain (also referred to as SRPBCC domain which stands for STA...

[]

0

[ "PFAM" ]

[ "PF08327" ]

[ "AHSA1" ]

[ 60446 ]

1

[]

0

[ "1x53", "1xfs", "1xn5", "1xn6", "1xuv", "1z94", "1zxf", "2gkd", "2il5", "2k5g", "2kew", "2kte", "2l65", "2l8o", "2l9p", "2lak", "2lcg", "2ldk", "2leq", "2lf2", "2lgh", "2luz", "2m89", "2n4a", "2n4b", "2nn5", "3eli", "3ni8", "3otl", "3pu2", "3put", "3q63"...

51

[ "PUB00020832", "PUB00020879", "PUB00020903", "PUB00102522", "PUB00102523", "PUB00102524" ]

[ "11554768", "12504007", "12604615", "20818668", "20177068", "33808352" ]

[ "p38: A novel protein that associates with the vesicular stomatitis virus glycoprotein.", "Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.", "Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecul...

[ 2001, 2002, 2003, 2010, 2010, 2021 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 211, 54790, 5218, 227 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 4, 2, 5, 4, 1, 3, 8, 1, 1, 4 ]

12

true

Domain

Activator of Hsp90 ATPase homologue 1/2-like, C-terminal

ASHA1/2-like_C

8

IPR013539

13,539

Adenylosuccinate lyase PurB, C-terminal

PurB_C

Domain

12,458

false

This domain is found at the C terminus of adenylosuccinate lyase (ASL; PurB in Escherichia coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain . ASL catalyses the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and ...

[ "GO:0004018", "GO:0006188" ]

[ "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity", "IMP biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08328" ]

[ "ASL_C" ]

[ 12458 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.3.2.2", "PWY-6123", "PWY-6124", "PWY-7219", "PWY-7234", "PWY-8289" ]

[ "EC:4.3.2.2", "METACYC:PWY-6123", "METACYC:PWY-6124", "METACYC:PWY-7219", "METACYC:PWY-7234", "METACYC:PWY-8289" ]

6

[ "2hvg", "2ptq", "2ptr", "2pts", "2qga", "3bhg", "3gzh", "4efc", "4mx2", "4nsl", "5e3v", "7t24", "7t29", "9bpl" ]

14

[ "PUB00020906" ]

[ "8530047" ]

[ "Characterization of the cDNA and the gene encoding murine adenylosuccinate lyase." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 367, 10705, 1185, 6, 195 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 1, 4, 24 ]

4

true

Domain

Adenylosuccinate lyase PurB, C-terminal

PurB_C

9

IPR013540

13,540

Chitinase A N-terminal

ChitinaseA_N

Domain

1,478

false

This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only β strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [ , ]. It is separated by a hinge region from...

[ "GO:0004568", "GO:0006032" ]

[ "chitinase activity", "chitin catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08329" ]

[ "ChitinaseA_N" ]

[ 1478 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.1.14", "PWY-6855", "PWY-6902", "PWY-7822" ]

[ "EC:3.2.1.14", "METACYC:PWY-6855", "METACYC:PWY-6902", "METACYC:PWY-7822" ]

4

[ "1ctn", "1edq", "1ehn", "1eib", "1ffq", "1ffr", "1k9t", "1nh6", "1rd6", "1x6l", "1x6n", "2wk2", "2wly", "2wlz", "2wm0", "3aro", "3arp", "3arq", "3arr", "3ars", "3art", "3aru", "3arv", "3arw", "3arx", "3ary", "3arz", "3as0", "3as1", "3as2", "3as3", "3b8s"...

49

[ "PUB00005240", "PUB00020836" ]

[ "7704527", "9377712" ]

[ "Crystal structure of a bacterial chitinase at 2.3 A resolution.", "Evolution of immunoglobulin-like modules in chitinases: their structural flexibility and functional implications." ]

[ 1994, 1997 ]

2

[]

0

null

[ "Bacteria", "Baculoviridae", "Methanoplanus endosymbiosus", "Protostomia", "ecological metagenomes" ]

[ 1239, 160, 1, 74, 4 ]

5

[]

0

true

Domain

Chitinase A N-terminal

ChitinaseA_N

2

IPR013542

13,542

Epoxyqueuosine reductase QueG, DUF1730

QueG_DUF1730

Domain

15,475

false

This domain of unknown function occurs in Epoxyqueuosine reductase QueG, an iron-sulphur cluster-binding protein, together with the 4Fe-4S binding domain ( ). QueG catalyses the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(...

[]

0

[ "PFAM" ]

[ "PF08331" ]

[ "QueG_DUF1730" ]

[ 15475 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.17.99.6", "PWY-6700", "PWY-8106" ]

[ "EC:1.17.99.6", "METACYC:PWY-6700", "METACYC:PWY-8106" ]

3

[ "5d08", "5d0a", "5d0b", "5d6s", "5t8y" ]

5

[ "PUB00058202" ]

[ "21502530" ]

[ "Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanophaga sp. ANME-1 ERB7", "Eukaryota", "unclassified sequences" ]

[ 15167, 1, 57, 250 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Epoxyqueuosine reductase QueG, DUF1730

QueG_DUF1730

2

IPR013543

13,543

Calcium/calmodulin-dependent protein kinase II, association-domain

Ca/CaM-dep_prot_kinase-assoc

Domain

16,978

false

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra...

[ "GO:0004683", "GO:0005516", "GO:0006468" ]

[ "calcium/calmodulin-dependent protein kinase activity", "calmodulin binding", "protein phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF08332" ]

[ "CaMKII_AD" ]

[ 16978 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.11.17", "R-BTA-3371571", "R-BTA-399719", "R-BTA-438066", "R-BTA-5576892", "R-BTA-5578775", "R-BTA-5673000", "R-BTA-5673001", "R-BTA-877300", "R-BTA-936837", "R-CEL-3371571", "R-CEL-4086398", "R-CEL-438066", "R-CEL-5578775", "R-CEL-936837", "R-DME-3371571", "R-DME-4086398", "R-...

[ "EC:2.7.11.17", "REACTOME:R-BTA-3371571", "REACTOME:R-BTA-399719", "REACTOME:R-BTA-438066", "REACTOME:R-BTA-5576892", "REACTOME:R-BTA-5578775", "REACTOME:R-BTA-5673000", "REACTOME:R-BTA-5673001", "REACTOME:R-BTA-877300", "REACTOME:R-BTA-936837", "REACTOME:R-CEL-3371571", "REACTOME:R-CEL-408639...

71

[ "1hkx", "2f86", "2ux0", "2w2c", "3h51", "3soa", "5ig0", "5ig3", "5ig4", "5ig5", "5u6y", "6of8", "6of9", "6w4o", "6w4p", "7rec", "7urw", "7ury", "7urz", "8syg", "8t15", "8t17", "8t18", "8t6k", "8t6q", "8uso", "9eoy" ]

27

[ "PUB00005115", "PUB00015362", "PUB00020114", "PUB00020846", "PUB00020889", "PUB00034898", "PUB00034899" ]

[ "3291115", "12368087", "12471243", "14993460", "12603201", "15078142", "15320712" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Evolution of protein kinase signaling from yeast to man.", "The protein kinase complement of the human genome.", "CaMKII, an enzyme on the move: regulation of temporospatial localization.", "Differential functi...

[ 1988, 2002, 2002, 2003, 2003, 2004, 2004 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 15, 1687, 15259, 17 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 177, 9, 59, 32, 45 ]

6

true

Domain

Calcium/calmodulin-dependent protein kinase II, association-domain

Ca/CaM-dep_prot_kinase-assoc

6

IPR013548

13,548

Plexin, cytoplasmic RasGAP domain

Plexin_cytoplasmic_RasGAP_dom

Domain

15,478

false

This domain is found at C terminus of various plexins (e.g. ). Plexins are receptors for semaphorins, and plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels [ , ]. The cytoplasmic region, which has been called a SEX domain [ ], is involved in downstream signalling ...

[ "GO:0017154" ]

[ "semaphorin receptor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08337" ]

[ "Plexin_cytopl" ]

[ 15478 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-416482", "R-CEL-416550", "R-CEL-416572", "R-CEL-9013405", "R-DME-416482", "R-DME-416572", "R-DME-416700", "R-DME-9013405", "R-DRE-399954", "R-DRE-399956", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-416482", "R-HSA-416550", "R-HSA-416572", "R-HSA-416700", "R-HSA-9...

[ "REACTOME:R-CEL-416482", "REACTOME:R-CEL-416550", "REACTOME:R-CEL-416572", "REACTOME:R-CEL-9013405", "REACTOME:R-DME-416482", "REACTOME:R-DME-416572", "REACTOME:R-DME-416700", "REACTOME:R-DME-9013405", "REACTOME:R-DRE-399954", "REACTOME:R-DRE-399956", "REACTOME:R-HSA-399954", "REACTOME:R-HSA-3...

36

[ "3hm6", "3ig3", "3ryt", "3su8", "3sua", "4m8m", "4m8n", "5e6p", "5v6r", "5v6t", "6vxk" ]

11

[ "PUB00020833", "PUB00020835", "PUB00020921", "PUB00020942" ]

[ "12559962", "11959816", "8570614", "15239959" ]

[ "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.", "Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis.", "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.", "Semaphorin...

[ 2003, 2002, 1996, 2004 ]

4

[]

0

null

[ "Opisthokonta" ]

[ 15478 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 44, 8, 35, 21, 22 ]

6

true

Domain

Plexin, cytoplasmic RasGAP domain

Plexin_cytoplasmic_RasGAP_dom

5

IPR013549

13,549

Domain of unknown function DUF1731

DUF1731

Domain

20,017

false

This domain of unknown function appears towards the C terminus of proteins of the NAD dependent epimerase/dehydratase family ( ) in bacteria, eukaryotes and archaea.

[]

0

[ "PFAM" ]

[ "PF08338" ]

[ "DUF1731" ]

[ 20017 ]

1

[]

0

[ "3oh8", "4b4o" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 22, 17382, 2322, 291 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 10, 1, 6, 1, 3, 5, 5 ]

9

true

Domain

Domain of unknown function DUF1731

DUF1731

3

IPR013550

13,550

RTX, C-terminal

RTX_C

Domain

273

false

This domain describes the C-terminal region of RTX toxins, which contains a secretion signal [ ]. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes [ ]. This region is found in association with the RTX N-terminal domain ( ) and multiple hemolysin-type calcium-bi...

[]

0

[ "PFAM" ]

[ "PF08339" ]

[ "RTX_C" ]

[ 273 ]

1

[ "REACTOME" ]

[ "R-HSA-9760173" ]

[ "REACTOME:R-HSA-9760173" ]

1

[]

0

[ "PUB00007655", "PUB00007656", "PUB00007657", "PUB00007658", "PUB00007659", "PUB00100829", "PUB00100830" ]

[ "1558765", "8800842", "10470043", "9521785", "8808931", "33260488", "30405113" ]

[ "Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria.", "Biological effects of RTX toxins: the possible role of lipopolysaccharide.", "The interaction between RTX toxins and target cells.", "The biochemistry of hemolysin toxin activation: characterization of HlyC...

[ 1992, 1995, 1999, 1998, 1996, 2020, 2018 ]

7

[]

0

null

[ "Pseudomonadota" ]

[ 273 ]

1

[]

0

true

Domain

RTX, C-terminal

RTX_C

7

IPR013551

13,551

Endoribonuclease YicC-like, C-terminal

YicC-like_C

Domain

15,060

false

This entry represents the C-terminal region of Endoribonuclease YicC from Escherichia coli and similar bacterial sequences. YicC has been shown to be important for cells in the stationary phase, and essential for growth at high temperatures [ ]. This protein contributes to degradation of the small RNA (sRNA) RhyB by 3'...

[]

0

[ "PFAM" ]

[ "PF08340" ]

[ "YicC-like_C" ]

[ 15060 ]

1

[ "EC" ]

[ "3.1.26.-" ]

[ "EC:3.1.26.-" ]

1

[ "8hvj", "8ver", "8ves" ]

3

[ "PUB00020576", "PUB00151088", "PUB00151089" ]

[ "1925027", "34815358", "34210798" ]

[ "Three genes preceding pyrE on the Escherichia coli chromosome are essential for survival and normal cell morphology in stationary culture and at high temperature.", "Discovery and initial characterization of YloC, a novel endoribonuclease in <i>Bacillus subtilis</i>.", "A fluorescence-based genetic screen reve...

[ 1991, 2022, 2021 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14750, 38, 272 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Endoribonuclease YicC-like, C-terminal

YicC-like_C

7

IPR013552

13,552

Thioester domain

Thioester_dom

Domain

3,500

false

This domain is found near the N terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue [ ].

[]

0

[ "PFAM" ]

[ "PF08341" ]

[ "TED" ]

[ 3500 ]

1

[]

0

[ "2xi9", "2xic", "2xid", "4bug", "4c0z", "5a0d", "5a0g", "5a0l", "5dcq", "6fwv", "6fwy", "6fx6" ]

12

[ "PUB00078721" ]

[ "20729215" ]

[ "A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction." ]

[ 2010 ]

1

[]

0

null

[ "Arabidopsis thaliana", "Bacteria", "Methanobacteriaceae", "metagenomes" ]

[ 1, 3485, 4, 10 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Thioester domain

Thioester_dom

6

IPR013555

13,555

Transient receptor ion channel domain

TRP_dom

Domain

11,680

false

This domain is found in a group of Trp proteins from animals, generally located C-terminal to ankyrin repeats ( ). There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors [ ]. Transient receptor potential (TRP) channels can be described a...

[]

0

[ "PFAM", "SMART" ]

[ "PF08344", "SM01420" ]

[ "TRP_2", "TRP_2" ]

[ 11592, 11664 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114508", "R-BTA-139853", "R-BTA-3295583", "R-CEL-114508", "R-CEL-139853", "R-CEL-3295583", "R-DME-3295583", "R-DME-5578775", "R-DME-983695", "R-HSA-114508", "R-HSA-139853", "R-HSA-3295583", "R-HSA-418890", "R-HSA-5578775", "R-HSA-9022699", "R-HSA-983695", "R-MMU-114508", "R-...

[ "REACTOME:R-BTA-114508", "REACTOME:R-BTA-139853", "REACTOME:R-BTA-3295583", "REACTOME:R-CEL-114508", "REACTOME:R-CEL-139853", "REACTOME:R-CEL-3295583", "REACTOME:R-DME-3295583", "REACTOME:R-DME-5578775", "REACTOME:R-DME-983695", "REACTOME:R-HSA-114508", "REACTOME:R-HSA-139853", "REACTOME:R-HSA...

26

[ "5yx9", "5z96", "5zbg", "6aei", "6cud", "6cv9", "6d7l", "6djs", "6g1k", "6jzo", "6uz8", "6uza", "6ysn", "7a6u", "7b05", "7b0j", "7b0s", "7b16", "7b1g", "7d4p", "7d4q", "7dxb", "7dxc", "7dxd", "7dxe", "7dxf", "7dxg", "7e4t", "7wdb", "7x6c", "7x6i", "8gvw"...

54

[ "PUB00007856", "PUB00054048", "PUB00054049", "PUB00054050" ]

[ "10051594", "18535090", "20025796", "20861159" ]

[ "Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel.", "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation cha...

[ 1999, 2008, 2009, 2010 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 11680 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 48, 6, 23, 34, 41 ]

6

true

Domain

Transient receptor ion channel domain

TRP_dom

5

IPR013557

13,557

AntA/AntB antirepressor

AntA/B_antirep

Domain

2,593

false

In Escherichia coli the two proteins AntA and AntB have 62% amino acid identities near their N termini [ ]. AntA appears to be encoded by a truncated and divergent copy of AntB. The two proteins are homologous to putative antirepressors found in numerous bacteriophages, such as the hypothetical antirepressor protein en...

[]

0

[ "PFAM" ]

[ "PF08346" ]

[ "AntA" ]

[ 2593 ]

1

[]

0

[]

0

[ "PUB00021035" ]

[ "12057959" ]

[ "Activation of prophage eib genes for immunoglobulin-binding proteins by genes from the IbrAB genetic island of Escherichia coli ECOR-9." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 2311, 7, 260, 15 ]

4

[]

0

true

Domain

AntA/AntB antirepressor

AntA/B_antirep

7

IPR013558

13,558

CTNNB1 binding, N-teminal

CTNNB1-bd_N

Domain

9,642

false

This region tends to appear at the N terminus of proteins also containing DNA-binding HMG (high mobility group) boxes ( ) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signalling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, c...

[]

0

[ "PFAM" ]

[ "PF08347" ]

[ "CTNNB1_binding" ]

[ 9642 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-209421", "R-DME-209441", "R-DRE-201722", "R-DRE-3769402", "R-DRE-4641265", "R-HSA-201722", "R-HSA-3769402", "R-HSA-381771", "R-HSA-4086398", "R-HSA-4411364", "R-HSA-4641265", "R-HSA-5339700", "R-HSA-8853884", "R-HSA-8951430", "R-HSA-9616222", "R-HSA-9733709", "R-HSA-9754189", ...

[ "REACTOME:R-DME-209421", "REACTOME:R-DME-209441", "REACTOME:R-DRE-201722", "REACTOME:R-DRE-3769402", "REACTOME:R-DRE-4641265", "REACTOME:R-HSA-201722", "REACTOME:R-HSA-3769402", "REACTOME:R-HSA-381771", "REACTOME:R-HSA-4086398", "REACTOME:R-HSA-4411364", "REACTOME:R-HSA-4641265", "REACTOME:R-H...

38

[ "1g3j", "1jdh", "1jpw", "2gl7", "3ouw", "3oux" ]

6

[ "PUB00020853", "PUB00020874", "PUB00020946" ]

[ "10080941", "9783587", "15765502" ]

[ "Identification of Tcf4 residues involved in high-affinity beta-catenin binding.", "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.", "Expression pattern of zebrafish tcf7 suggests unexplored domains of Wnt/beta-catenin activity." ]

[ 1999, 1998, 2005 ]

3

[]

0

null

[ "Bilateria", "bird metagenome" ]

[ 9641, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 80, 3, 44, 29, 34 ]

5

true

Domain

CTNNB1 binding, N-teminal

CTNNB1-bd_N

3

IPR013560

13,560

Domain of unknown function DUF1722

DUF1722

Domain

6,084

false

This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from Escherichia coli.

[]

0

[ "PFAM" ]

[ "PF08349" ]

[ "DUF1722" ]

[ 6084 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Escherichia phage 1H12", "Eukaryota", "unclassified sequences" ]

[ 171, 5860, 1, 12, 40 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF1722

DUF1722

5

IPR013561

13,561

Methanogenesis regulatory protein FilR1, middle domain

FilR1_middle_dom

Domain

2,864

false

This archaeal domain of unknown function has been found at the middle of Methanogenesis regulatory protein FilR1 [ , ] and at the C-terminal of several transcriptional regulators of the ArsR family (see ). FilR1 is a member of the two-component regulatory system FilI/FilRs which is involved in the regulation of methano...

[]

0

[ "PFAM" ]

[ "PF08350" ]

[ "FilR1_middle" ]

[ 2864 ]

1

[]

0

[]

0

[ "PUB00091155", "PUB00098067" ]

[ "29263101", "24748383" ]

[ "Phyletic Distribution and Lineage-Specific Domain Architectures of Archaeal Two-Component Signal Transduction Systems.", "Characterization of an archaeal two-component system that regulates methanogenesis in Methanosaeta harundinacea." ]

[ 2018, 2014 ]

2

[]

0

null

[ "Archaea", "Kribbella hippodromi", "ecological metagenomes" ]

[ 2843, 1, 20 ]

3

[]

0

true

Domain

Methanogenesis regulatory protein FilR1, middle domain

FilR1_middle_dom

7

IPR013562

13,562

TmcA/NAT10, N-terminal

TmcA/NAT10_N

Domain

8,877

false

This entry represents a domain found at the N-terminal of TmcA from bacteria and NAT10 from eukaryotes. The bacterial tRNA(Met) cytidine acetyltransferase (TmcA) catalyses the formation of N(4)-acetylcytidine (ac4C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and either ATP or GTP [ ]. T...

[]

0

[ "PFAM" ]

[ "PF08351" ]

[ "TmcA_N" ]

[ 8877 ]

1

[ "EC", "REACTOME" ]

[ "2.3.1.193", "R-HSA-6790901" ]

[ "EC:2.3.1.193", "REACTOME:R-HSA-6790901" ]

2

[ "2zpa", "5jpq", "5oql", "5wlc", "6ke6", "6lqp", "6lqq", "6lqr", "6lqu", "6lqv", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqb", "6zqc", "7ajt", "7d63", "7mq8", "7mq9", "7suk", "9aym", "9b0e", "9b0i", "9g33", "9j3c", "9n6v", "9n6w", "9n6x", "9n6y"...

36

[ "PUB00050413", "PUB00056806", "PUB00076725", "PUB00076726", "PUB00107449" ]

[ "19322199", "18668122", "25653167", "25402480", "31491951" ]

[ "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon.", "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon.", "Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor...

[ 2009, 2008, 2015, 2014, 2019 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 600, 3453, 4799, 25 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 1, 2, 3, 1, 4, 2, 1, 1, 8, 1, 1, 3 ]

13

true

Domain

TmcA/NAT10, N-terminal

TmcA/NAT10_N

9

IPR013563

13,563

Oligopeptide/dipeptide ABC transporter, C-terminal

Oligopep_ABC_C

Domain

162,544

false

This entry represents the C-terminal of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain ( ). All characterised members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide t...

[ "GO:0000166", "GO:0005524", "GO:0015833" ]

[ "nucleotide binding", "ATP binding", "peptide transport" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "NCBIFAM" ]

[ "PF08352", "TIGR01727" ]

[ "oligo_HPY", "oligo_HPY" ]

[ 162487, 112280 ]

2

[ "EC", "REACTOME", "REACTOME" ]

[ "7.4.2", "R-HSA-1222538", "R-HSA-9927020" ]

[ "EC:7.4.2", "REACTOME:R-HSA-1222538", "REACTOME:R-HSA-9927020" ]

3

[ "4fwi", "7z15", "7z16", "7z17", "7z18", "7z19", "8j5q", "8j5r", "8j5s", "8j5t", "8wd9", "8wda", "8wdb", "8xfc", "8z1v", "8z1w", "8z1x", "8z1y", "8z1z", "8z21" ]

20

[ "PUB00073663", "PUB00163227" ]

[ "16109926", "30250240" ]

[ "The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.", "Subjective age and adiposity: evidence from five samples." ]

[ 2005, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5452, 154579, 318, 2195 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 10 ]

2

true

Domain

Oligopeptide/dipeptide ABC transporter, C-terminal

Oligopep_ABC_C

8

IPR013564

13,564

Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT, C-terminal

MurT_C

Domain

6,744

false

This entry represents the C-terminal domain of MurT ligase mostly from bacteria. MurT is part of the bi-enzymatic complex MurT-GatD involved in the amidation of the α-carboxyl group of the D-isoglutamate residue in Lipid II in the peptidoglycan layer to produce D-isoglutamine. This domain contains an aspartate at posit...

[]

0

[ "PFAM" ]

[ "PF08353" ]

[ "MurT_C" ]

[ 6744 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "6.3.5.13", "PWY-5265", "PWY-6471" ]

[ "EC:6.3.5.13", "METACYC:PWY-5265", "METACYC:PWY-6471" ]

3

[ "6fqb", "6gs2", "6h5e", "7q8e", "9sq9", "9sqj" ]

6

[ "PUB00094480" ]

[ "30154570" ]

[ "Structural basis of cell wall peptidoglycan amidation by the GatD/MurT complex of Staphylococcus aureus." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriales", "metagenomes" ]

[ 6609, 30, 105 ]

3

[]

0

true

Domain

Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT, C-terminal

MurT_C

2

IPR013565

13,565

Fatty acid synthase beta subunit AflB /Fas1-like, central domain

Fas1/AflB-like_central

Domain

4,196

false

The domain has been identified in fungi and bacteria. This domain can be found in fatty acid synthase beta subunit from fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synth...

[ "GO:0004318" ]

[ "enoyl-[acyl-carrier-protein] reductase (NADH) activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08354" ]

[ "Fas1-AflB-like_hel" ]

[ 4196 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "1.3.1.9", "2.3.1.38", "2.3.1.39", "2.3.1.86", "3.1.2.14", "4.2.1.59", "GenProp1436", "PWY-4381", "PWY-5142", "PWY-5147", "PWY-5366", "PWY-5367", "PWY-5966", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-5994", "PWY-6113", "PWY-6282", "PWY-6519", "PWY-6799", "PWY-7388", "PWY-7...

[ "EC:1.3.1.9", "EC:2.3.1.38", "EC:2.3.1.39", "EC:2.3.1.86", "EC:3.1.2.14", "EC:4.2.1.59", "GP:GenProp1436", "METACYC:PWY-4381", "METACYC:PWY-5142", "METACYC:PWY-5147", "METACYC:PWY-5366", "METACYC:PWY-5367", "METACYC:PWY-5966", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989",...

39

[ "2uv8", "2vkz", "3hmj", "4v58", "4v59", "4v8l", "4v8v", "4v8w", "6gjc", "6ql5", "6ql6", "6ql7", "6ql9", "6ta1", "6u5t", "6u5u", "6u5v", "6u5w", "6wc7", "7bc4", "7q5s", "7tui", "8prv", "8prw", "8ps1", "8ps2", "8ps8", "8ps9", "8psa", "8psf", "8psg", "8psj"...

42

[ "PUB00006544", "PUB00083132" ]

[ "3528750", "15006741" ]

[ "The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains.", "Clustered pathway genes in aflatoxin biosynthesis." ]

[ 1986, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured organism" ]

[ 1384, 2811, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Fatty acid synthase beta subunit AflB /Fas1-like, central domain

Fas1/AflB-like_central

8

IPR013566

13,566

Mitochondrial Rho GTPase 1/3, EF hand associated, type-1

EF_hand_assoc_1

Domain

8,115

false

This entry represents a region that typically appears on the C terminus of EF hands in eukaryotic GTP-binding proteins such as Mitochondrial Rho GTPase 1 from Bos taurus (MIRO-1), the product of the gene Arht, which may be involved in mitochondrial homeostasis and apoptosis[ ]. The EF hand domains of these proteins may...

[]

0

[ "PFAM" ]

[ "PF08355" ]

[ "EF_assoc_1" ]

[ 8115 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.5.-", "R-BTA-5689880", "R-BTA-9013419", "R-BTA-9013425", "R-CEL-5689880", "R-CEL-9013419", "R-CEL-9013425", "R-DDI-9013419", "R-DDI-9013425", "R-DME-5689880", "R-DME-9013419", "R-DME-9013425", "R-DRE-5689880", "R-DRE-9013419", "R-DRE-9013425", "R-HSA-5689880", "R-HSA-9013419", ...

[ "EC:3.6.5.-", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-9013419", "REACTOME:R-BTA-9013425", "REACTOME:R-CEL-5689880", "REACTOME:R-CEL-9013419", "REACTOME:R-CEL-9013425", "REACTOME:R-DDI-9013419", "REACTOME:R-DDI-9013425", "REACTOME:R-DME-5689880", "REACTOME:R-DME-9013419", "REACTOME:R-DME-9013...

28

[ "4c0j", "4c0k", "4c0l", "5ksz", "5kty", "5ku1", "9e2p" ]

7

[ "PUB00020991", "PUB00099839" ]

[ "15218247", "26729171" ]

[ "Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase.", "MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology." ]

[ 2004, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 8115 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 12, 4, 5, 6, 1, 9, 12, 1, 1, 23 ]

12

true

Domain

Mitochondrial Rho GTPase 1/3, EF hand associated, type-1

EF_hand_assoc_1

3

IPR013567

13,567

EF hand associated, type-2

EF_hand_assoc_2

Domain

8,485

false

This region predominantly appears near EF-hands ( ) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.

[]

0

[ "PFAM" ]

[ "PF08356" ]

[ "EF_assoc_2" ]

[ 8485 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.5.-", "R-BTA-5689880", "R-BTA-9013419", "R-BTA-9013425", "R-CEL-5689880", "R-CEL-9013419", "R-CEL-9013425", "R-DDI-9013419", "R-DDI-9013425", "R-DME-5689880", "R-DME-9013419", "R-DME-9013425", "R-DRE-5689880", "R-DRE-9013419", "R-DRE-9013425", "R-HSA-5689880", "R-HSA-9013419", ...

[ "EC:3.6.5.-", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-9013419", "REACTOME:R-BTA-9013425", "REACTOME:R-CEL-5689880", "REACTOME:R-CEL-9013419", "REACTOME:R-CEL-9013425", "REACTOME:R-DDI-9013419", "REACTOME:R-DDI-9013425", "REACTOME:R-DME-5689880", "REACTOME:R-DME-9013419", "REACTOME:R-DME-9013...

28

[ "4c0j", "4c0k", "4c0l", "5ksz", "5kty", "5ku1", "9e2p" ]

7

[]

0

[]

0

null

[ "Eukaryota" ]

[ 8485 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 12, 4, 5, 5, 1, 12, 12, 1, 1, 31 ]

12

true

Domain

EF hand associated, type-2

EF_hand_assoc_2

2

IPR013568

13,568

SEFIR domain

SEFIR_dom

Domain

8,997

false

The SEFIR domain (after SEFs and IL17Rs) is a conserved sequence segment identified in transmembrane receptors (including SEFs, IL17Rs) and soluble factors (including CIKS/ACT1) in eukaryotes and bacteria. In addition to the SEFIR sequence homology, SEFs and IL17Rs share the same architecture. Their extracellular regio...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08357", "PS51534" ]

[ "SEFIR", "SEFIR" ]

[ 8293, 7778 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5674135", "R-DRE-5674135", "R-HSA-448424", "R-HSA-5674135", "R-HSA-9705671", "R-MMU-5674135" ]

[ "REACTOME:R-CEL-5674135", "REACTOME:R-DRE-5674135", "REACTOME:R-HSA-448424", "REACTOME:R-HSA-5674135", "REACTOME:R-HSA-9705671", "REACTOME:R-MMU-5674135" ]

6

[ "3vbc", "4nux", "5y8e", "5y8f" ]

4

[ "PUB00020849", "PUB00095140", "PUB00095141" ]

[ "12765832", "19825828", "24120361" ]

[ "The STIR-domain superfamily in signal transduction, development and immunity.", "Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.", "An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis." ]

[ 2003, 2009, 2013 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Klebsiella phage ST15-OXA48phi14.1", "Metazoa", "ecological metagenomes" ]

[ 12, 1265, 1, 7711, 8 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 56, 19, 15, 17 ]

5

true

Domain

SEFIR domain

SEFIR_dom

2

IPR013569

13,569

Carlavirus coat

Carlavirus_coat_N

Domain

1,126

false

This domain is found together with the viral coat protein domain ( ) in coat/capsid proteins of the plant infecting Carlavirus. It is required for genome encapsidation by forming ribonucleoprotein complexes along with TGB1 helicase and viral RNA. The N- and the C terminus of this coat protein can be exposed on the surf...

[]

0

[ "PFAM" ]

[ "PF08358" ]

[ "Flexi_CP_N" ]

[ 1126 ]

1

[]

0

[]

0

[ "PUB00044053", "PUB00044054", "PUB00044055" ]

[ "18192032", "17006596", "16279199" ]

[ "A degenerate primer allows amplification of part of the 3'-terminus of three distinct carlavirus species.", "Coat protein gene diversity among Chrysanthemum virus B isolates from India.", "[Complete sequence analysis on potato virus M infecting Solanum muricatum]" ]

[ 2008, 2007, 2003 ]

3

[]

0

null

[ "Eukaryota", "Riboviria" ]

[ 3, 1123 ]

2

[]

0

true

Domain

Carlavirus coat

Carlavirus_coat_N

4

IPR013570

13,570

Transcription regulator YsiA, C-terminal

Tscrpt_reg_YsiA_C

Domain

2,831

false

The members of this family are thought to be TetR-type (tetracycline resistance) transcriptional regulators that bear particular similarity to YsiA ( ). This entry represents the C-terminal domain.

[]

0

[ "PFAM" ]

[ "PF08359" ]

[ "TetR_C_4" ]

[ 2831 ]

1

[]

0

[ "1vi0", "3whb", "3whc", "5gp9", "5gpa", "5gpc" ]

6

[]

0

[]

0

null

[ "Bacteria", "Ignelater luminosus", "Methanolobus", "ecological metagenomes" ]

[ 2786, 1, 3, 41 ]

4

[]

0

true

Domain

Transcription regulator YsiA, C-terminal

Tscrpt_reg_YsiA_C

1

IPR013571

13,571

Transcription regulator QacR, C-terminal

Tscrpt_reg_QacR_C

Domain

883

false

This entry represents the C-terminal domain found in the multidrug-binding transcription regulator QacR ( ) from Staphylococcus aureus, which is a member of the TetR (tetracycline-resistance) transcriptional regulator family of proteins. QacR is able to bind various environmental agents, which include a number of catio...

[ "GO:0003700", "GO:0045892" ]

[ "DNA-binding transcription factor activity", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08360" ]

[ "TetR_C_5" ]

[ 883 ]

1

[]

0

[ "1jt0", "1jt6", "1jtx", "1jty", "1jum", "1jup", "1jus", "1qvt", "1qvu", "1rkw", "1rpw", "2dtz", "2g0e", "2gby", "2hq5", "3bqz", "3br0", "3br1", "3br2", "3br3", "3br5", "3br6", "3bt9", "3btc", "3bti", "3btj", "3btl", "3pm1" ]

28

[ "PUB00014320", "PUB00020943" ]

[ "11739955", "9660841" ]

[ "Structural mechanisms of QacR induction and multidrug recognition.", "QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA." ]

[ 2001, 1998 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Pocillopora meandrina", "ecological metagenomes" ]

[ 8, 872, 1, 2 ]

4

[]

0

true

Domain

Transcription regulator QacR, C-terminal

Tscrpt_reg_QacR_C

4

IPR013572

13,572

Transcription regulator MAATS, C-terminal

Tscrpt_reg_MAATS_C

Domain

5,431

false

This entry is named after the various transcriptional regulatory proteins that it contains, including MtrR ( ), AcrR ( ), ArpR ( ), TtgR ( ) and SmeT ( ). These are members of the TetR (tetracycline resistance) family of transcriptional repressors, that are involved in the control of expression of multidrug resistance ...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08361" ]

[ "TetR_C_2" ]

[ 5431 ]

1

[]

0

[ "2qop", "2uxh", "2uxi", "2uxo", "2uxp", "2uxu", "2xdn", "3bcg", "3lhq", "3vib", "5daj", "5h9t", "6of0", "7jnp", "7ju3", "7k1a", "7k1c", "7kd8", "8fw0", "8fw3", "8fw8", "8ssh", "8v90" ]

23

[ "PUB00020860", "PUB00020913", "PUB00020934" ]

[ "1720861", "11160799", "12384340" ]

[ "Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli.", "Identification and molecular characterization of an efflux system involved in Pseudomonas putida S12 multidrug resistance.", "Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug ef...

[ 1991, 2001, 2002 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanocella", "unclassified sequences" ]

[ 5406, 8, 2, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Transcription regulator MAATS, C-terminal

Tscrpt_reg_MAATS_C

9

IPR013573

13,573

Transcription regulator YcdC, C-terminal

Tscrpt_reg_YcdC_C

Domain

7,238

false

This entry represents the C-terminal domain found in the hypothetical transcriptional regulators RutR and YcdC ( ) from Escherichia coli. Both of these proteins are member of the TetR (tetracycline resistance) transcriptional regulator family of proteins. RutR negatively controls the transcription of the rut operon inv...

[ "GO:0045892" ]

[ "negative regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08362" ]

[ "TetR_C_3" ]

[ 7238 ]

1

[]

0

[ "3loc", "4jyk", "4x1e", "4xk4", "6z1b" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 7198, 8, 32 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcription regulator YcdC, C-terminal

Tscrpt_reg_YcdC_C

2

IPR013574

13,574

Glucan-binding protein C/Surface antigen I/II, V-domain

Glucan-bd_C/Surface_Ag-I/II_V

Domain

911

false

This domain is found in glucan-binding protein C (GbpC) and in the V-region of surface protein antigen; both these proteins belong to the Spa family of Streptococcal proteins [ ]. This domain consists of a β-supersandwich of 18 β-strands in two sheets.

[]

0

[ "PFAM" ]

[ "PF08363" ]

[ "GbpC" ]

[ 911 ]

1

[]

0

[ "1jmm", "2wd6", "3iox", "3ipk", "5uqz", "6cam", "6e36", "6evu", "6ged", "6q2k", "6q2l", "6tzl", "6ubv" ]

13

[ "PUB00020918", "PUB00028752", "PUB00042622", "PUB00042623" ]

[ "9009329", "12054777", "17241168", "16390340" ]

[ "Cloning and sequence analysis of the gbpC gene encoding a novel glucan-binding protein of Streptococcus mutans.", "Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site.", "Comparison of glucan-binding proteins in cariogenicity of Str...

[ 1997, 2002, 2007, 2006 ]

4

[]

0

null

[ "Bacillati", "Mus musculus", "human gut metagenome", "unclassified Caudoviricetes" ]

[ 904, 1, 4, 2 ]

4

[ "Mus musculus" ]

[ 1 ]

1

true

Domain

Glucan-binding protein C/Surface antigen I/II, V-domain

Glucan-bd_C/Surface_Ag-I/II_V

6

IPR013575

13,575

Initiation factor 2 associated domain, bacterial

IF2_assoc_dom_bac

Domain

8,941

false

This entry represents a small conserved domain found towards the N terminus of bacterial translation initiation factor IF-2 family proteins. The domain is also found in the eukaryotic translation initiation factor 4 gamma in yeast and in a hypothetical Euglenozoa protein of unknown function.

[]

0

[ "PFAM" ]

[ "PF08364" ]

[ "IF2_assoc" ]

[ 8941 ]

1

[]

0

[ "3jcj", "3jcn", "5me0", "5me1", "7uiu", "7unq", "7unr", "7unt", "7unu", "7unv", "7unw", "9h9h" ]

12

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8828, 21, 92 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Initiation factor 2 associated domain, bacterial

IF2_assoc_dom_bac

6

IPR013576

13,576

Insulin-like growth factor II E-peptide, C-terminal

IGF2_C

Domain

1,182

false

Insulin is found in many animals, and is involved in the regulation of normal glucose homeostasis. It also has other specific physiological effects, such as increasing the permeability of cells to monosaccharides, amino acids and fatty acids, and accelerating glycolysis and glycogen synthesis in the liver [ ]. Insulin ...

[]

0

[ "PFAM" ]

[ "PF08365" ]

[ "IGF2_C" ]

[ 1182 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-2404192", "R-BTA-2428928", "R-BTA-2428933", "R-BTA-381426", "R-GGA-114608", "R-GGA-2404192", "R-GGA-2428928", "R-GGA-2428933", "R-GGA-381426", "R-HSA-114608", "R-HSA-2404192", "R-HSA-2428928", "R-HSA-2428933", "R-HSA-381426", "R-MMU-114608", "R-MMU-2404192", ...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-2404192", "REACTOME:R-BTA-2428928", "REACTOME:R-BTA-2428933", "REACTOME:R-BTA-381426", "REACTOME:R-GGA-114608", "REACTOME:R-GGA-2404192", "REACTOME:R-GGA-2428928", "REACTOME:R-GGA-2428933", "REACTOME:R-GGA-381426", "REACTOME:R-HSA-114608", "REACTOME:R-H...

30

[ "8u4c", "8u4e", "8vjb", "8vjc", "8ysz" ]

5

[ "PUB00003970", "PUB00003972", "PUB00003973", "PUB00013535", "PUB00013536", "PUB00013537", "PUB00013538", "PUB00013539", "PUB00013540", "PUB00013541", "PUB00013542", "PUB00020909", "PUB00020923", "PUB00023078", "PUB00037375", "PUB00053639", "PUB00053640", "PUB00053641", "PUB000536...

[ "503234", "6243748", "6107857", "11874691", "9822601", "9725901", "7519375", "9660801", "12379487", "12379489", "7504269", "12324491", "8215015", "2036417", "9141131", "10601981", "8735594", "8683595", "1319992" ]

[ "Nucleotide sequence of a cDNA clone encoding human preproinsulin.", "Sequence of the human insulin gene.", "Hormone families: pancreatic hormones and homologous growth factors.", "IGF-binding protein-5: flexible player in the IGF system and effector on its own.", "Structure of the IGF-binding domain of the...

[ 1979, 1980, 1980, 2002, 1998, 1998, 1994, 1998, 2002, 2002, 1993, 2002, 1993, 1991, 1997, 1999, 1996, 1996, 1992 ]

19

[]

0

null

[ "Bilateria", "Marinobacter guineae" ]

[ 1181, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 10 ]

4

true

Domain

Insulin-like growth factor II E-peptide, C-terminal

IGF2_C

3

IPR013577

13,577

Lethal giant larvae homologue 2

LLGL2

Domain

9,642

false

This domain is found in lethal giant larvae homologue 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn [ ]. It has been identified in eukaryotes and tends to be found together with WD repeats ( ).

[]

0

[ "PFAM" ]

[ "PF08366" ]

[ "LLGL" ]

[ 9642 ]

1

[]

0

[ "6n8p", "6n8q", "6n8r", "6n8s", "8r3y", "9ejk", "9ejl", "9ejm" ]

8

[ "PUB00020936" ]

[ "14767561" ]

[ "Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 9642 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 52, 6, 20, 12, 29 ]

6

true

Domain

Lethal giant larvae homologue 2

LLGL2

2

IPR013578

13,578

Peptidase M16C associated

Peptidase_M16C_assoc

Domain

8,254

false

This domain appears in eukaryotes as well as bacteria and tends to be found near the C terminus of metalloproteases and related sequences belonging to MEROPS peptidase family M16 (subfamily M16C, clan ME), PreP subfamily. PREP is an ATP-independent protease that degrades both mitochondrial and chloroplastic transit pep...

[ "GO:0006508" ]

[ "proteolysis" ]

[ "biological_process" ]

1

[ "PFAM", "SMART" ]

[ "PF08367", "SM01264" ]

[ "M16C_assoc", "M16C_associated" ]

[ 8012, 8058 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-DME-1268020", "R-DRE-1268020", "R-HSA-1268020", "R-MMU-1268020", "R-SCE-1268020", "R-SPO-1268020", "R-XTR-1268020" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-DME-1268020", "REACTOME:R-DRE-1268020", "REACTOME:R-HSA-1268020", "REACTOME:R-MMU-1268020", "REACTOME:R-SCE-1268020", "REACTOME:R-SPO-1268020", "REACTOME:R-XTR-1268020" ]

9

[ "2fge", "3s5h", "3s5i", "3s5k", "3s5m", "4l3t", "4nge", "4rpu", "6xos", "6xot", "6xou", "6xov", "6xow", "7di7", "7dia", "7dij", "7vpe", "8ho4", "8ho5", "8wxw", "8wxz", "8wyt", "8wyu", "8wyx", "8wyy" ]

25

[ "PUB00063594" ]

[ "12138166" ]

[ "Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Podoviridae sp. ctAmM4", "unclassified sequences" ]

[ 2854, 5346, 1, 53 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 14, 2, 2, 17, 1, 2, 1, 5, 1, 1, 3 ]

11

true

Domain

Peptidase M16C associated

Peptidase_M16C_assoc

2

IPR013579

13,579

FAST kinase-like protein, subdomain 2

FAST_2

Domain

5,924

false

This domain represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases ( ) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector ...

[]

0

[ "PFAM" ]

[ "PF08368" ]

[ "FAST_2" ]

[ 5924 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6793080", "R-HSA-9837092", "R-HSA-9937008" ]

[ "REACTOME:R-HSA-6793080", "REACTOME:R-HSA-9837092", "REACTOME:R-HSA-9937008" ]

3

[ "9gek" ]

1

[ "PUB00012815" ]

[ "7544399" ]

[ "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis." ]

[ 1995 ]

1

[]

0

null

[ "Metazoa" ]

[ 5924 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 2, 19, 13, 19 ]

5

true

Domain

FAST kinase-like protein, subdomain 2

FAST_2

3

IPR013580

13,580

Light-independent protochlorophyllide reductase subunit B-like, C-terminal

LI-POR_suB-like_C

Domain

3,515

false

This domain is found in Light-independent protochlorophyllide reductase subunit B (LI-POR subunit B, also known as DPOR subunit B) and similar bacterial and plant chloroplast proteins. It often appears at the C-terminal of nitrogenase component 1 type oxidoreductases ( ) and sometimes independently in certain bacterial...

[ "GO:0016491", "GO:0015979", "GO:0015995" ]

[ "oxidoreductase activity", "photosynthesis", "chlorophyll biosynthetic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF08369" ]

[ "PCP_red" ]

[ 3515 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.3.7.7", "PWY-5531", "PWY-7159" ]

[ "EC:1.3.7.7", "METACYC:PWY-5531", "METACYC:PWY-7159" ]

3

[ "2kru", "2l09", "2xdq", "2ynm", "3aek", "3aeq", "3aer", "3aes", "3aet", "3aeu", "8vqh", "8vqi", "8vqj", "9buo", "9e7h" ]

15

[ "PUB00099822", "PUB00099825" ]

[ "23341615", "16571720" ]

[ "Structure of ADP-aluminium fluoride-stabilized protochlorophyllide oxidoreductase complex.", "A second nitrogenase-like enzyme for bacteriochlorophyll biosynthesis: reconstitution of chlorophyllide a reductase with purified X-protein (BchX) and YZ-protein (BchY-BchZ) from Rhodobacter capsulatus." ]

[ 2013, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 2086, 1340, 6, 83 ]

4

[]

0

true

Domain

Light-independent protochlorophyllide reductase subunit B-like, C-terminal

LI-POR_suB-like_C

1

IPR013581

13,581

Plant PDR ABC transporter associated

PDR_assoc

Domain

12,876

false

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o...

[]

0

[ "PFAM" ]

[ "PF08370" ]

[ "PDR_assoc" ]

[ 12876 ]

1

[]

0

[]

0

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00020871", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "12430018", "11080142", "11532960", "11421270" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2002, 2000, 2001, 2001 ]

12

[]

0

null

[ "Eukaryota" ]

[ 12876 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 73, 48, 235 ]

3

true

Domain

Plant PDR ABC transporter associated

PDR_assoc

8

IPR013583

13,583

Multiple C2 domain and Transmembrane region Proteins, C-terminal

MCTP_C

Domain

10,146

false

This domain is found at the C terminus of a group of animal and plant proteins that belong to the family Multiple C2 domain and Transmembrane region Proteins (MCTPs), including Protein QUIRKY and FT-interacting protein 1/3/4 from Arabidopsis thaliana [ , , , and Multiple C2 and transmembrane domain-containing protein 1...

[]

0

[ "PFAM" ]

[ "PF08372" ]

[ "PRT_C" ]

[ 10146 ]

1

[]

0

[]

0

[ "PUB00102365", "PUB00102366", "PUB00103911", "PUB00103936", "PUB00103937", "PUB00103938" ]

[ "22529749", "29742441", "29259105", "28485711", "23773997", "24173806" ]

[ "FTIP1 is an essential regulator required for florigen transport.", "FTIP-Dependent STM Trafficking Regulates Shoot Meristem Development in Arabidopsis.", "Characterization of Multiple C2 Domain and Transmembrane Region Proteins in Arabidopsis.", "MCTP is an ER-resident calcium sensor that stabilizes synaptic...

[ 2012, 2018, 2018, 2017, 2013, 2013 ]

6

[]

0

null

[ "Eukaryota" ]

[ 10146 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 67, 17, 2, 3, 3, 36, 3, 48 ]

8

true

Domain

Multiple C2 domain and Transmembrane region Proteins, C-terminal

MCTP_C

9

IPR013584

13,584

RAP domain

RAP

Domain

10,632

false

The ~60-residue RAP (an acronym for RNA-binding domain abundant in Apicomplexans) domain is found in various proteins in eukaryotes. It is particularly abundant in apicomplexans and might mediate a range of cellular functions through its potential interactions with RNA [ ]. The RAP domain consists of multiple blocks of...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF08373", "PS51286", "SM00952" ]

[ "RAP", "RAP", "RAP" ]

[ 9063, 9575, 9409 ]

3

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6793080", "R-HSA-9837092", "R-HSA-9937008" ]

[ "REACTOME:R-HSA-6793080", "REACTOME:R-HSA-9837092", "REACTOME:R-HSA-9937008" ]

3

[ "9g6k", "9gek", "9i05" ]

3

[ "PUB00020843" ]

[ "15501674" ]

[ "RAP--a putative RNA-binding domain." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 54, 276, 10297, 4, 1 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 10, 5, 16, 14, 1, 23, 2 ]

8

true

Domain

RAP domain

RAP

3

IPR013586

13,586

26S proteasome non-ATPase regulatory subunit 3, C-terminal

PSMD3_C

Domain

6,311

false

This eukaryotic domain is found at the C-terminal of 26S proteasome regulatory subunits including the non-ATPase regulatory subunit 3 (PSMD3), which is essential for proteasomal function [ ]. It occurs together with the PCI/PINT domain ( ). Intracellular proteins, including short-lived proteins such as cyclin, Mos, Myc...

[ "GO:0030234", "GO:0042176", "GO:0000502" ]

[ "enzyme regulator activity", "regulation of protein catabolic process", "proteasome complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF08375" ]

[ "Rpn3_C" ]

[ 6311 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA-4608870", "R-B...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA...

300

[ "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz", "5vhf", "5vhh", "5vhi", "5vhs"...

110

[ "PUB00016866", "PUB00020915", "PUB00034667", "PUB00034668", "PUB00043308", "PUB00086026" ]

[ "15571806", "10490625", "15890341", "9741626", "16566573", "28583440" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.", "Functional characterization of rpn3 uncovers a distinct 19S proteasomal subunit requirement for ubiquitin-dependent proteolysis of cell cycle regulatory proteins in budding yeast.", "Proteasome plasticity.", "A subcomplex of ...

[ 2004, 1999, 2005, 1998, 2006, 2017 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6311 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 9, 4, 1, 9, 2, 1, 1, 18 ]

12

true

Domain

26S proteasome non-ATPase regulatory subunit 3, C-terminal

PSMD3_C

3

IPR013587

13,587

Nitrate/nitrite sensing protein

Nitrate/nitrite_sensing

Domain

15,851

false

The nitrate and nitrite-sensing (NIT) domain is a (~250 aa) sensor domain found in various receptor components of signal transduction pathways from different bacterial lineages [ ]. The NIT domain is predicted to be all α-helical in structure [ ].

[]

0

[ "PFAM" ]

[ "PF08376" ]

[ "NIT" ]

[ 15851 ]

1

[]

0

[ "4akk" ]

1

[ "PUB00013947" ]

[ "12633990" ]

[ "The NIT domain: a predicted nitrate-responsive module in bacterial sensory receptors." ]

[ 2003 ]

1

[]

[ "IPR010910" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 14822, 939, 90 ]

3

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Domain

Nitrate/nitrite sensing protein

Nitrate/nitrite_sensing

4

IPR013588

13,588

MAP2/Tau projection

MAP2_projctn

Domain

1,702

false

This domain is found in the microtubule-associated protein 2 (MAP2)/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologues. All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats ( ), and a N-terminal projection domain of varying size. This domain has a net negative c...

[]

0

[ "PFAM" ]

[ "PF08377" ]

[ "MAP2_projctn" ]

[ 1702 ]

1

[]

0

[]

0

[ "PUB00020508", "PUB00020854" ]

[ "15642108", "11576531" ]

[ "The MAP2/Tau family of microtubule-associated proteins.", "AFM force measurements on microtubule-associated proteins: the projection domain exerts a long-range repulsive force." ]

[ 2005, 2001 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 1702 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 50, 5, 8, 7 ]

4

true

Domain

MAP2/Tau projection

MAP2_projctn

7

IPR013589

13,589

Bacterial transglutaminase-like, N-terminal

Bac_transglu_N

Domain

17,405

false

This region is found towards the N terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain ( ).

[]

0

[ "PFAM" ]

[ "PF08379" ]

[ "Bact_transglu_N" ]

[ 17405 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati", "metagenomes" ]

[ 17285, 13, 24, 83 ]

4

[]

0

true

Domain

Bacterial transglutaminase-like, N-terminal

Bac_transglu_N

2