LiteFold/InterPro · Datasets at Hugging Face

IPR013216

13,216

Methyltransferase type 11

Methyltransf_11

Domain

215,526

false

This entry represents a methyltransferase domain found in a large variety of SAM-dependent methyltransferases including, but not limited to: Arsenite methyltransferase ( ) which converts arsenical compounds to their methylated forms [ ] Biotin synthesis protein bioC, which is involved in the early stages of biotin bios...

[ "GO:0008757" ]

[ "S-adenosylmethionine-dependent methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08241" ]

[ "Methyltransf_11" ]

[ 215526 ]

1

[ "EC", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "GenProp1337", "GenProp1594", "GenProp1609", "R-HSA-6782315", "R-HSA-6790901", "R-HSA-6791226", "R-HSA-6798695", "R-HSA-6799198", "R-MMU-6791226", "R-MMU-6799198", "R-RNO-6799198", "R-SPO-6798695" ]

[ "EC:2.1.1", "GP:GenProp1337", "GP:GenProp1594", "GP:GenProp1609", "REACTOME:R-HSA-6782315", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-6791226", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-6799198", "REACTOME:R-SPO-67...

13

[ "1vl5", "1vlm", "1xxl", "2avn", "2glu", "2gs9", "2o57", "2p8j", "2pxx", "2yqz", "2yr0", "3bkw", "3bus", "3ccf", "3dlc", "3e23", "3ege", "3i9f", "3l8d", "3sm3", "3vc1", "3vc2", "4hg2", "4ine", "4krh", "4kri", "4pne", "4qtt", "4qtu", "5bp9", "5cm2", "5fcd"...

54

[ "PUB00006319", "PUB00013843", "PUB00014680", "PUB00015329", "PUB00028118", "PUB00028119", "PUB00028120", "PUB00028121", "PUB00028122", "PUB00028123", "PUB00028124", "PUB00054125", "PUB00057957", "PUB00057958" ]

[ "7897657", "10419476", "12429089", "8501034", "11790780", "9063571", "10848611", "9593144", "1479344", "12737817", "14999102", "12826405", "16225687", "21858014" ]

[ "Universal catalytic domain structure of AdoMet-dependent methyltransferases.", "Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis.", "The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyl...

[ 1995, 1999, 2002, 1993, 2002, 1997, 2000, 1998, 1992, 2003, 2004, 2003, 2005, 2011 ]

14

[]

[ "IPR031164" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6054, 150024, 56105, 148, 3195 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 138, 9, 33, 8, 3, 18, 30, 8, 89, 17, 4, 6, 173 ]

13

true

Domain

Methyltransferase type 11

Methyltransf_11

4

IPR013217

13,217

Methyltransferase type 12

Methyltransf_12

Domain

47,717

false

Methyl transfer from the ubiquitous donor S-adenosyl-L-methionine (SAM) to either nitrogen, oxygen or carbon atoms is frequently employed in diverse organisms ranging from bacteria to plants and mammals. The reaction is catalysed by methyltransferases (Mtases) and modifies DNA, RNA, proteins and small molecules, such a...

[]

0

[ "PFAM" ]

[ "PF08242" ]

[ "Methyltransf_12" ]

[ 47717 ]

1

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METAC...

[ "2.3.1", "2.3.1.-", "GenProp1220", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679"...

[ "EC:2.3.1", "EC:2.3.1.-", "GP:GenProp1220", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "ME...

232

[ "2vz8", "2vz9", "3jwg", "3jwi", "4piv", "5c37", "5mpt", "5thy", "5thz", "5wmm", "6cca", "6d6y", "6ect", "6ecu", "6ecv", "6ecw", "6ecx", "6hp1", "6hp2", "6kjg", "6kji", "6nna", "7cpx", "7cpy", "7dmb", "7ezg", "7f1e", "8eyi", "8eyk", "8ftr", "8fts", "8ftv"...

55

[ "PUB00016741", "PUB00022593", "PUB00026061", "PUB00028117", "PUB00085066", "PUB00099616", "PUB00099673" ]

[ "8281755", "15340920", "11746687", "8810903", "26172141", "27959549", "22329759" ]

[ "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers.", "Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes.", "Crystal structure of YecO f...

[ 1993, 2004, 2001, 1996, 2015, 2016, 2012 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 373, 26341, 20715, 20, 268 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 2, 10, 3, 2, 14, 10, 3, 7, 21, 1, 4, 15 ]

13

true

Domain

Methyltransferase type 12

Methyltransf_12

2

IPR013218

13,218

Kinetochore-associated protein Dsn1/Mis13

Dsn1/Mis13

Family

2,754

false

This entry represents the kinetochore-associated protein Dsn1/Mis13. In Saccharomyces cerevisiae, Dsn1 acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joini...

[ "GO:0007059", "GO:0051301", "GO:0000444" ]

[ "chromosome segregation", "cell division", "MIS12/MIND type complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08202", "PTHR14778" ]

[ "MIS13", "" ]

[ 2536, 2647 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-6798695", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-6798695", "R-MMU-68877", "R-MMU-9648025", "R-SCE-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-...

16

[ "5lsi", "5lsj", "5lsk", "5t58", "8ppr", "8q5h" ]

6

[ "PUB00017334", "PUB00019931", "PUB00044193", "PUB00044201" ]

[ "12455957", "14633972", "16079914", "17035632" ]

[ "Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.", "Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.", "Molecular analysis of kinetochore architecture in fission yeast.", "Reconstruction of the kinetoch...

[ 2002, 2003, 2005, 2006 ]

4

[]

0

null

[ "Eukaryota", "Holtiella tumoricola", "Lactobacillus phage LpeD", "bird metagenome" ]

[ 2751, 1, 1, 1 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 6, 3, 1, 3, 1, 1 ]

7

true

Family

Kinetochore-associated protein Dsn1/Mis13

Dsn1/Mis13

9

IPR013219

13,219

Small ribosomal subunit protein mS33

Ribosomal_mS33

Family

3,814

false

This entry represents the small ribosomal subunit protein mS33 from eukaryotes, previously known as S27 in yeast and S33 in humans [ , , ]. It is a small 106 residue protein. The evolutionary history of the mitoribosomal proteome that is encoded by a diverse subset of eukaryotic genomes, reveals an ancestral ribosome o...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08293", "PTHR13362" ]

[ "MRP-S33", "" ]

[ 3800, 3592 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "3j9m", "3jd5", "5aj3", "5aj4", "5mrc", "5mre", "5mrf", "6gaw", "6gaz", "6neq", "6nf8", "6nu2", "6nu3", "6rw4", "6rw5", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6yw5", "6ywe", "6ywx", "6ywy", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse"...

92

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00019866", "PUB00044381", "PUB00044382", "PUB00080279" ]

[ "11297922", "11290319", "11114498", "11278769", "11344316", "17604309", "24524803" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues.", "Identification of four proteins from the s...

[ 2001, 2001, 2000, 2001, 2001, 2007, 2014 ]

7

[]

0

null

[ "Eukaryota" ]

[ 3814 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 4, 3, 1, 2, 2, 1, 1, 3 ]

12

true

Family

Small ribosomal subunit protein mS33

Ribosomal_mS33

2

IPR013220

13,220

E3 ubiquitin-protein ligase substrate receptor Mms22, budding yeast

Mms22_budding_yeast

Family

21

false

Mms22 is a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex Rtt101(Mms1-Mms22), a complex that promotes replication through damaged DNA [ , ]. Mms22 may play an important role for the stabilisation of protein components at the replication fork during replication stress and thereb...

[ "GO:0006281", "GO:0006974", "GO:0031297", "GO:0005634", "GO:0035361" ]

[ "DNA repair", "DNA damage response", "replication fork processing", "nucleus", "Cul8-RING ubiquitin ligase complex" ]

[ "biological_process", "biological_process", "biological_process", "cellular_component", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF007808" ]

[ "MMS22" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00074932", "PUB00074933", "PUB00074934" ]

[ "20139071", "21593207", "18704118" ]

[ "Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.", "Mms1 and Mms22 stabilize the replisome during replication stress.", "Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA." ]

[ 2010, 2011, 2008 ]

3

[ "IPR019021" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 21 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

E3 ubiquitin-protein ligase substrate receptor Mms22, budding yeast

Mms22_budding_yeast

9

IPR013221

13,221

Mur ligase, central

Mur_ligase_cen

Domain

163,580

false

This entry represents the central domain from all four stage 2 Mur enzymes: UDP-N-acetylmuramate-L-alanine ligase (MurC), UDP-N-acetylmuramoylalanine-D-glutamate ligase (MurD), UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase (MurE), and UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF)....

[ "GO:0005524", "GO:0016881", "GO:0009058" ]

[ "ATP binding", "acid-amino acid ligase activity", "biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF08245" ]

[ "Mur_ligase_M" ]

[ 163580 ]

1

[ "EC" ]

[ "6.3.2" ]

[ "EC:6.3.2" ]

1

[ "1e0d", "1e8c", "1eeh", "1fgs", "1gg4", "1gqq", "1gqy", "1j6u", "1jbv", "1jbw", "1o5z", "1p31", "1p3d", "1uag", "1w78", "1w7k", "2am1", "2am2", "2f00", "2gc5", "2gc6", "2gca", "2gcb", "2jff", "2jfg", "2jfh", "2uag", "2uuo", "2uup", "2vor", "2vos", "2vtd"...

148

[ "PUB00008020", "PUB00035788", "PUB00035789", "PUB00035790", "PUB00035791", "PUB00035792", "PUB00101154" ]

[ "9652408", "17139082", "17427948", "16595662", "16322581", "16934839", "18974047" ]

[ "Molecular characterization of cyanophycin synthetase, the enzyme catalyzing the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin).", "Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).", "Targeted molecular dynamics simulation studies of...

[ 1998, 2006, 2007, 2006, 2005, 2006, 2008 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 823, 155701, 3871, 4, 3181 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 16, 6, 7, 1, 16 ]

5

true

Domain

Mur ligase, central

Mur_ligase_cen

8

IPR013222

13,222

Glycosyl hydrolase family 98, putative carbohydrate-binding module

Glyco_hyd_98_carb-bd

Domain

5,870

false

This entry represents a putative carbohydrate binding module (NPCBM) domain found at the N terminus of glycosyl hydrolase family 98 proteins [ ]. Proteins containing this domain include CpGH98 from C. perfringens. It specifically hydrolyses fucose-containing trisaccharides from the glycotopes of blood groups A and B an...

[]

0

[ "PFAM", "SMART" ]

[ "PF08305", "SM00776" ]

[ "NPCBM", "NPCBM" ]

[ 5868, 5012 ]

2

[]

0

[ "2vmg", "2vmh", "2vmi", "2vng", "2vno", "2vnr", "2ygl", "2ygm", "7jrl", "7jrm", "7js4", "8pvs" ]

12

[ "PUB00072702", "PUB00072703", "PUB00100103" ]

[ "16212961", "15618227", "34061031" ]

[ "Analysis of glycoside hydrolase family 98: catalytic machinery, mechanism and a novel putative carbohydrate binding module.", "A clostridial endo-beta-galactosidase that cleaves both blood group A and B glycotopes: the first member of a new glycoside hydrolase family, GH98.", "Bacterial death and TRADD-N domai...

[ 2005, 2005, 2021 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 5686, 133, 5, 46 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Glycosyl hydrolase family 98, putative carbohydrate-binding module

Glyco_hyd_98_carb-bd

1

IPR013223

13,223

Ribonuclease B, N-terminal OB domain

RNase_B_OB_dom

Domain

18,647

false

This domain includes the N-terminal OB domain found in ribonuclease B proteins in one or two copies.

[]

0

[ "PFAM" ]

[ "PF08206" ]

[ "OB_RNB" ]

[ 18647 ]

1

[ "EC" ]

[ "3.1.13.1" ]

[ "EC:3.1.13.1" ]

1

[ "2id0", "2ix0", "2ix1", "5xgu", "8cdu", "8cdv", "8cec", "8ced", "8cee" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine phage" ]

[ 18462, 22, 162, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Ribonuclease B, N-terminal OB domain

RNase_B_OB_dom

1

IPR013225

13,225

Transcriptional repressor PaaX-like, C-terminal

PaaX_C

Domain

8,598

false

This entry represents the C-terminal domain of the Transcriptional repressor PaaX from Escherichia coli and similar bacterial proteins. PaaX is involved in metabolism of phenylacetic acid [ , ]. This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phe...

[]

0

[ "PFAM" ]

[ "PF08223" ]

[ "PaaX_C" ]

[ 8598 ]

1

[]

0

[ "3kfw", "8a39" ]

2

[ "PUB00010200", "PUB00015522" ]

[ "9748275", "10766858" ]

[ "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway.", "Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli." ]

[ 1998, 2000 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "Sulfolobaceae", "unclassified sequences" ]

[ 8497, 2, 33, 66 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcriptional repressor PaaX-like, C-terminal

PaaX_C

6

IPR013226

13,226

Pal1 cell morphology

Pal1

Family

2,646

false

Pal1 is a membrane associated protein that is involved in the maintenance of cylindrical cellular morphology. It localises to sites of active growth. Pal1 physically interacts and displays overlapping localisation with the Huntingtin-interacting-protein (Hip1)-related protein Sla2p/End4p [ ]. Fission yeast Pal1 is invo...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08316", "PTHR28307" ]

[ "Pal1", "" ]

[ 2602, 2616 ]

2

[]

0

[]

0

[ "PUB00017116" ]

[ "15975911" ]

[ "The novel fission yeast protein Pal1p interacts with Hip1-related Sla2p/End4p and is involved in cellular morphogenesis." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2646 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 2 ]

3

true

Family

Pal1 cell morphology

Pal1

9

IPR013228

13,228

PE-PPE, C-terminal

PE-PPE_C

Domain

3,439

false

This domain is found C-terminal to the PE ( ) and PPE ( ) domains. The secondary structure of this domain is predicted to be a mixture of α-helices and β-strands [ ]. This domain is found in a variety of proteins, including esterase PPE63, PE16 , uncharacterised PPE family protein PPE28 and related proteins containing ...

[]

0

[ "PFAM" ]

[ "PF08237" ]

[ "PE-PPE" ]

[ 3439 ]

1

[]

0

[]

0

[ "PUB00017149", "PUB00054031", "PUB00054032", "PUB00054033", "PUB00103913", "PUB00103914", "PUB00103929", "PUB00103930" ]

[ "12711809", "19602151", "18981138", "18267304", "32138343", "32139546", "25155747", "25275011" ]

[ "Sequence analysis corresponding to the PPE and PE proteins in Mycobacterium tuberculosis and other genomes.", "Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families.", "The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage respon...

[ 2003, 2009, 2008, 2007, 2020, 2020, 2014, 2014 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 3350, 2, 87 ]

3

[]

0

true

Domain

PE-PPE, C-terminal

PE-PPE_C

6

IPR013229

13,229

PEGA

Domain

7,913

false

This domain is found in both archaea and bacteria and has similarity to S-layer (surface layer) proteins. It is named after the characteristic PEGA sequence motif found in this domain. The secondary structure of this domain is predicted to be β-strands.

[]

0

[ "PFAM" ]

[ "PF08308" ]

[ "PEGA" ]

[ 7913 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctNs77", "unclassified sequences" ]

[ 654, 7008, 15, 1, 235 ]

5

[]

0

true

Domain

PEGA

6

IPR013230

13,230

Peptidase M15A, C-terminal

Peptidase_M15A_C

Domain

5,575

false

This entry represents the C-terminal domain of zinc D-Ala-D-Ala carboxypeptidases from Streptomyces species and non-peptidase homologues that belong to MEROPS peptidase family M15 (subfamily M15A, clan MD) [ ].

[]

0

[ "PFAM" ]

[ "PF08291" ]

[ "Peptidase_M15_3" ]

[ 5575 ]

1

[]

0

[ "1lbu" ]

1

[ "PUB00031641" ]

[ "15044722" ]

[ "Similar active sites in lysostaphins and D-Ala-D-Ala metallopeptidases." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 10, 4821, 15, 536, 193 ]

5

[]

0

true

Domain

Peptidase M15A, C-terminal

Peptidase_M15A_C

6

IPR013231

13,231

Periviscerokinin

Family

376

false

Perviscerokinin neuropeptides are found in the abdominal perisympathetic organs of insects. They mediate visceral muscle contractile activity (myotropic activity). CAPA, which are in the periviscerokinin and pyrokinin peptide families, has potential medical importance. This is due to its myotropic effects on, for examp...

[]

0

[ "PFAM" ]

[ "PF08259" ]

[ "Periviscerokin" ]

[ 376 ]

1

[]

0

[]

0

[ "PUB00043388", "PUB00043389" ]

[ "18495123", "16952053" ]

[ "Neuropeptide discovery in Ixodoidea: an in silico investigation using publicly accessible expressed sequence tags.", "Biology of the CAPA peptides in insects." ]

[ 2008, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 16, 360 ]

2

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Family

Periviscerokinin

9

IPR013232

13,232

Bacteriophage T7, Gp1.1

Phage_T7_Gp1.1

Family

500

false

Gene 1.1 in Bacteriophage T7 encodes a 42 amino acid protein, rich in basic amino acids suggesting its interaction with nucleic acids [ ]. Many homologues are present in different T7 and T3-like bacteriophage.

[]

0

[ "PFAM" ]

[ "PF08200" ]

[ "Phage_T7_1_1" ]

[ 500 ]

1

[]

0

[]

0

[ "PUB00017170" ]

[ "6254001" ]

[ "Nucleotide sequence of the primary origin of bacteriophage T7 DNA replication: relationship to adjacent genes and regulatory elements." ]

[ 1980 ]

1

[]

0

null

[ "Pseudomonadati", "Ricinus communis", "Viruses" ]

[ 5, 1, 494 ]

3

[]

0

true

Family

Bacteriophage T7, Gp1.1

Phage_T7_Gp1.1

5

IPR013233

13,233

Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1

PIG-X/PBN1

Family

4,209

false

Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I [ ]. These enzymes are involved in the transfer of sugar molecules. They probably act by stabilizing the mannosyltransferase PIG-M (GPI14 in yeast) [ , ].

[ "GO:0006506", "GO:0005789" ]

[ "GPI anchor biosynthetic process", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF08320", "SM00780" ]

[ "PIG-X", "PIG-X" ]

[ 4207, 3493 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-162710", "R-MMU-162710", "R-RNO-162710" ]

[ "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710", "REACTOME:R-RNO-162710" ]

3

[]

0

[ "PUB00020120", "PUB00089750" ]

[ "15635094", "16418276" ]

[ "Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I.", "Pbn1p: an essential endoplasmic reticulum membrane protein required for protein processing in the endoplasmic reticulum of budding yeast." ]

[ 2005, 2006 ]

2

[]

[ "IPR040039", "IPR042322" ]

0

2

0

[ "Eukaryota" ]

[ 4209 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 6, 5, 4, 9, 4, 1, 3, 9, 1, 1, 3 ]

11

true

Family

Glycosylphosphatidylinositol-mannosyltransferase I, PIG-X/PBN1

PIG-X/PBN1

7

IPR013234

13,234

PIGA, GPI anchor biosynthesis

PIGA_GPI_anchor_biosynthesis

Domain

4,755

false

This domain is found on phosphatidylinositol N-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with the disease paroxysmal nocturnal haemoglobinuria [ ].

[ "GO:0006506" ]

[ "GPI anchor biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08288" ]

[ "PIGA" ]

[ 4755 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "2.4.1.198", "R-HSA-162710", "R-MMU-162710" ]

[ "EC:2.4.1.198", "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710" ]

3

[]

0

[ "PUB00017109" ]

[ "12488505" ]

[ "The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic cells." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4755 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 1, 75, 6, 1, 3, 3, 1, 1, 14 ]

12

true

Domain

PIGA, GPI anchor biosynthesis

PIGA_GPI_anchor_biosynthesis

8

IPR013236

13,236

M protein trans-acting positive regulator (MGA), PRD domain

Mga_PRD_dom

Domain

594

false

Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [ ]. This region corresponds to the PRD like region.

[]

0

[ "PFAM" ]

[ "PF08270" ]

[ "PRD_Mga" ]

[ 594 ]

1

[]

0

[ "5way" ]

1

[ "PUB00010185" ]

[ "11952907" ]

[ "Two DNA-binding domains of Mga are required for virulence gene activation in the group A streptococcus." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Graphocephala atropunctata" ]

[ 593, 1 ]

2

[]

0

true

Domain

M protein trans-acting positive regulator (MGA), PRD domain

Mga_PRD_dom

1

IPR013237

13,237

DNA primase/helicase Gp4, N-terminal, Bacteriophage T7-like

Phage_T7_Gp4_N

Domain

4,152

false

This entry is represented by bacteriophage T7 DNA helicase/primase (also known as Gp4), an ATP-dependent DNA helicase and primase that is essential for viral DNA replication and recombination [ , , ]. Primase activity synthesizes short RNA primers at the sequence 5'-GTC-3' on the lagging strand that the polymerase elon...

[ "GO:0004386", "GO:0008270" ]

[ "helicase activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART" ]

[ "PF08273", "SM00778" ]

[ "Zn_Ribbon_Prim", "Prim_Zn_Ribbon" ]

[ 3795, 4040 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.-", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179" ]

[ "EC:2.7.7.-", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719", "METACYC:PWY-7735", "METACYC:PWY-7737", "METACYC:PWY-7769", "METACYC:PWY-7...

18

[ "1nui", "6n7i", "6n7n", "6n7s", "6n7t", "6n7v", "6n9u", "6n9v", "6n9w", "6n9x" ]

10

[ "PUB00017335", "PUB00028395", "PUB00056008", "PUB00084200", "PUB00100558", "PUB00100559", "PUB00100560" ]

[ "8253092", "10892646", "9185573", "21606333", "22977246", "32009150", "9139692" ]

[ "Phage P4 alpha protein is multifunctional with origin recognition, helicase and primase activities.", "Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides.", "Characterization and crystallization of the helicase domain of bacteriophage T7 gene 4 protein."...

[ 1993, 2000, 1997, 2011, 2012, 2020, 1997 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Natrialbaceae", "Viruses", "metagenomes" ]

[ 3367, 6, 2, 758, 19 ]

5

[]

0

true

Domain

DNA primase/helicase Gp4, N-terminal, Bacteriophage T7-like

Phage_T7_Gp4_N

6

IPR013238

13,238

RNA polymerase III, subunit Rpc25

RNA_pol_III_Rbc25

Domain

4,483

false

Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III [ ].

[]

0

[ "PFAM" ]

[ "PF08292" ]

[ "RNA_pol_Rbc25" ]

[ 4483 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-76061", "R-DDI-76066", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071", "R-SCE-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-DDI-76061", "REACTOME:R-DDI-76066", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-MMU-76071", "...

15

[ "2ckz", "3ayh", "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7ast", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l", "7z1m"...

56

[ "PUB00017156" ]

[ "15612920" ]

[ "Rpc25, a conserved RNA polymerase III subunit, is critical for transcription initiation." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4483 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 1, 3, 1, 8, 5, 1, 1, 5 ]

12

true

Domain

RNA polymerase III, subunit Rpc25

RNA_pol_III_Rbc25

1

IPR013239

13,239

RNA polymerase I, subunit Rpa14, fungi

RNA_polI_Rpa14

Family

172

false

Saccharomyces cerevisiae RNA polymerase I (Pol I) is a complex consisting of 14 subunits. Subunit Rpa14 forms part of a Pol I subcomplex consisting of Rpa14 and and Rpa43. The Rpa14 and Rpa43 heterodimer is proposed to play a role in the recruitment of Pol I to the promoter [ ]. This protein contains a HRDC domain homo...

[]

0

[ "PFAM" ]

[ "PF08203" ]

[ "RNA_polI_A14" ]

[ 172 ]

1

[]

0

[ "2rf4", "4c2m", "4c3h", "4c3i", "4c3j", "4ym7", "5g5l", "5lmx", "5m3f", "5m3m", "5m5w", "5m5x", "5m5y", "5m64", "5n5y", "5n5z", "5n60", "5n61", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6h67", "6h68", "6hko", "6hlq", "6hlr", "6hls", "6rqh", "6rql", "6rqt"...

48

[ "PUB00017151", "PUB00092063" ]

[ "15647272", "12888498" ]

[ "The fission yeast protein Ker1p is an ortholog of RNA polymerase I subunit A14 in Saccharomyces cerevisiae and is required for stable association of Rrn3p and RPA21 in RNA polymerase I.", "Structural and functional homology between the RNAP(I) subunits A14/A43 and the archaeal RNAP subunits E/F." ]

[ 2005, 2003 ]

2

[]

0

null

[ "Dikarya" ]

[ 172 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

RNA polymerase I, subunit Rpa14, fungi

RNA_polI_Rpa14

7

IPR013240

13,240

DNA-directed RNA polymerase I, subunit RPA34

DNA-dir_RNA_pol1_su_RPA34

Family

2,367

false

This is a family of proteins conserved from yeasts to human. Subunit A34 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription [ ]. It forms a heterodimer with RPA49 which stimulates transcript elongati...

[ "GO:0006360" ]

[ "transcription by RNA polymerase I" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08208", "PTHR15484" ]

[ "RNA_polI_A34", "" ]

[ 2281, 470 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427413", "R-HSA-5250924", "R-HSA-73762", "R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-MMU-73772", "R-MMU-73863" ]

[ "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73772", "REACTOME:R-HSA-73863", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-73762", "REACTOME:R-MMU-73772", "REACTOME:R-MMU-73863" ]

9

[ "3nff", "3nfg", "4c2m", "4c3h", "4c3i", "4c3j", "4ym7", "5g5l", "5lmx", "5m3f", "5m3m", "5m5w", "5m5x", "5m5y", "5m64", "5n5y", "5n5z", "5n60", "5n61", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6h67", "6h68", "6hko", "6rqh", "6rql", "6rqt", "6rrd", "6rui"...

48

[ "PUB00017113", "PUB00076664" ]

[ "9121426", "24153182" ]

[ "A34.5, a nonessential component of yeast RNA polymerase I, cooperates with subunit A14 and DNA topoisomerase I to produce a functional rRNA synthesis machine.", "RNA polymerase I structure and transcription regulation." ]

[ 1997, 2013 ]

2

[]

0

null

[ "Candidatus Cardinium hertigii", "Eukaryota" ]

[ 1, 2366 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 9, 4, 2, 1, 2, 1, 1 ]

7

true

Family

DNA-directed RNA polymerase I, subunit RPA34

DNA-dir_RNA_pol1_su_RPA34

4

IPR013241

13,241

RNase P, subunit Pop3

RNase_P_Pop3

Family

1,331

false

This family of fungal proteins form a subunit of RNase P, the ribonucleoprotein enzyme that cleaves the leader sequence of precursor tRNAs to generate mature tRNAs. The structure of Pop3 has been assigned the L7Ae/L30e fold [ ]. This RNA-binding fold is also present in human RNase P subunit Rpp38, raising the possibili...

[ "GO:0006364", "GO:0008033" ]

[ "rRNA processing", "tRNA processing" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08228", "PTHR28272" ]

[ "RNase_P_pop3", "" ]

[ 1006, 1283 ]

2

[]

0

[ "6agb", "6ah3", "7c79", "7c7a" ]

4

[ "PUB00017150" ]

[ "15613537" ]

[ "3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1331 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

RNase P, subunit Pop3

RNase_P_Pop3

2

IPR013246

13,246

SAGA complex, Sgf11 subunit

SAGA_su_Sgf11

Family

1,692

false

The Sgf11 (SAGA-associated factor 11) family is a SAGA complex subunit in Saccharomyces cerevisiae (Baker's yeast). The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well...

[]

0

[ "HAMAP" ]

[ "MF_03047" ]

[ "Sgf11" ]

[ 1692 ]

1

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "3m99", "3mhh", "3mhs", "4fjc", "4fk5", "4w4u", "4wa6", "4zux", "6aqr", "6t9l" ]

10

[ "PUB00017172" ]

[ "15657441" ]

[ "H2B ubiquitin protease Ubp8 and Sgf11 constitute a discrete functional module within the Saccharomyces cerevisiae SAGA complex." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 1691, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 1, 4, 2, 4, 1, 1 ]

7

true

Family

SAGA complex, Sgf11 subunit

SAGA_su_Sgf11

4

IPR013248

13,248

Secretory component protein Psh3/Shr3

Psh3/Shr3

Family

1,927

false

This family of proteins are membrane localised chaperones that are required for correct plasma membrane localisation of amino acid permeases (AAPs) [ ]. Shr3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of Shr3, AAPs are retained in the ER.

[]

0

[ "PFAM", "PIRSF", "PANTHER", "SMART" ]

[ "PF08229", "PIRSF029187", "PTHR28228", "SM00786" ]

[ "SHR3_chaperone", "Shr3_AAP_chap", "", "SHR3_chaperone" ]

[ 1912, 1048, 1846, 1860 ]

4

[]

0

[]

0

[ "PUB00017155" ]

[ "15623581" ]

[ "Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "Mycobacteriales", "freshwater metagenome" ]

[ 1921, 4, 2 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Secretory component protein Psh3/Shr3

Psh3/Shr3

1

IPR013249

13,249

RNA polymerase sigma factor 70, region 4 type 2

RNA_pol_sigma70_r4_t2

Domain

294,209

false

This entry represents region 4 of sigma-70 like sigma-factors involved in binding to the -35 promoter element via a helix-turn-helix motif [ ]. The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. ...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "PFAM" ]

[ "PF08281" ]

[ "Sigma70_r4_2" ]

[ 294209 ]

1

[]

0

[ "1or7", "2h27", "2o8x", "3vep", "3vfz", "4cxf", "5fgm", "5uxx", "5wuq", "5wur", "5xe7", "5zx2", "5zx3", "6dxo", "6in7", "6jbq", "6jcx", "6jcy", "6jhe", "6kon", "6koo", "6kop", "6koq", "7qh5", "8z6g" ]

25

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "11931761", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Structure of the bacterial RNA polymerase promoter specificity sigma subunit.", "...

[ 1988, 1992, 1986, 2002, 2015 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 113, 290853, 227, 207, 2809 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 2 ]

2

true

Domain

RNA polymerase sigma factor 70, region 4 type 2

RNA_pol_sigma70_r4_t2

5

IPR013251

13,251

DASH complex subunit Spc19

DASH_Spc19

Family

1,587

false

Spc19 is a component of the DASH complex, which is a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and...

[ "GO:0008608", "GO:0005876", "GO:0042729" ]

[ "attachment of spindle microtubules to kinetochore", "spindle microtubule", "DASH complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF08287", "PTHR28262" ]

[ "DASH_Spc19", "" ]

[ 1586, 1532 ]

2

[]

0

[ "6cfz", "8q84", "8q85" ]

3

[ "PUB00017114", "PUB00017174" ]

[ "11782438", "11799062" ]

[ "Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation.", "The mitotic spindle is required for loading of the DASH complex onto the kinetochore." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Fungi" ]

[ 1587 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

DASH complex subunit Spc19

DASH_Spc19

8

IPR013252

13,252

Kinetochore-Ndc80 subunit Spc24

Ndc80_Spc24

Family

2,477

false

Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08286", "PTHR22142" ]

[ "Spc24", "" ]

[ 2383, 2157 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025", "R-XTR-141444", "R-XTR-2467813", "R-XTR-2500257", "R-XTR-5663220", "R-XTR-68877", "R...

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-MMU-68877", "REACTOME:R-MM...

18

[ "2ftx", "2fv4", "2ve7", "3iz0", "3vz9", "3vza", "4geq", "5t6j", "5tcs", "5td8", "7kdf", "8ppr", "8q5h", "8v10", "8v11" ]

15

[ "PUB00008439", "PUB00088195" ]

[ "11266451", "17521635" ]

[ "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.", "The Ndc80 complex: hub of kinetochore activity." ]

[ 2001, 2007 ]

2

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 2, 2475 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 7, 4, 1, 2, 1, 1 ]

7

true

Family

Kinetochore-Ndc80 subunit Spc24

Ndc80_Spc24

2

IPR013253

13,253

Spc7 kinetochore protein domain

Spc7_domain

Domain

1,759

false

This domain is found in cell division proteins which are required for kinetochore-spindle association [ ]. Proteins containing this domain include budding yeast Spc105 and fission yeast Spc7. Spc7 is a component of the NMS (Ndc80-MIND-Spc7) super complex, which has a role in kinetochore function during late meiotic pro...

[]

0

[ "PFAM", "SMART" ]

[ "PF08317", "SM00787" ]

[ "Spc7", "Spc7" ]

[ 1733, 1695 ]

2

[]

0

[]

0

[ "PUB00017166", "PUB00069741", "PUB00069742" ]

[ "15371542", "19893618", "22711988" ]

[ "The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.", "Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.", "Sos7, an essential component of the conserved...

[ 2004, 2009, 2012 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1759 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Spc7 kinetochore protein domain

Spc7_domain

4

IPR013254

13,254

Sperm-activating peptide

Sperm_act_pept

Family

21

false

The sperm-activating peptides (SAPs) are isolated in egg-conditioned media (egg jelly) of sea urchins. SAPs have several effects on sea urchin spermatozoa: stimulate sperm respiration and motility through intracellular alkalinization, transient elevation of cAMP, cGMP and Ca 2+ levels in sperm cells [ , ].

[]

0

[ "PFAM" ]

[ "PF08250" ]

[ "Sperm_act_pep" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00017138", "PUB00017173" ]

[ "1756858", "2059627" ]

[ "Determination of the amino acid sequence of an intramolecular disulfide linkage-containing sperm-activating peptide by tandem mass spectrometry.", "Identification of a novel amino acid, o-bromo-L-phenylalanine, in egg-associated peptides that activate spermatozoa." ]

[ 1991, 1991 ]

2

[]

0

null

[ "Echinacea" ]

[ 21 ]

1

[]

0

true

Family

Sperm-activating peptide

Sperm_act_pept

7

IPR013255

13,255

Chromosome segregation protein Spc25, C-terminal

Spc25_C

Domain

3,916

false

The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [ , , ]. This entry represents the C-terminal domain of Spc25 [ ].

[ "GO:0007059", "GO:0031262" ]

[ "chromosome segregation", "Ndc80 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08234" ]

[ "Spindle_Spc25" ]

[ 3916 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-141444", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-5663220", "R-BTA-68877", "R-BTA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R...

[ "REACTOME:R-BTA-141444", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-68877", "REACTOME:R-BTA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HS...

30

[ "2ve7", "3iz0", "3vz9", "3vza", "8ppr", "8q5h" ]

6

[ "PUB00008439", "PUB00017148", "PUB00088195", "PUB00097440" ]

[ "11266451", "14738735", "17521635", "28502666" ]

[ "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.", "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.", "The Ndc80 complex: hub o...

[ 2001, 2004, 2007, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3916 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 1, 3, 1, 9, 3, 1, 14 ]

9

true

Domain

Chromosome segregation protein Spc25, C-terminal

Spc25_C

1

IPR013256

13,256

Chromatin SPT2

Chromatin_SPT2

Family

4,628

false

This entry includes the Saccharomyces cerevisiae (Baker's yeast) protein SPT2 which is a chromatin protein involved in transcriptional regulation [ ]. These proteins shows conservation of several domains across numerous species, including having a cluster of positively charged amino acids. This cluster probably functio...

[]

0

[ "PFAM", "SMART" ]

[ "PF08243", "SM00784" ]

[ "SPT2", "SPT2" ]

[ 4492, 4402 ]

2

[]

0

[ "5bs7", "5bsa" ]

2

[ "PUB00017105", "PUB00044600", "PUB00044601" ]

[ "15563464", "16788068", "16449659" ]

[ "Functional domains of the yeast chromatin protein Sin1p/Spt2p can bind four-way junction and crossing DNA structures.", "Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p.", "Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, ch...

[ 2005, 2006, 2006 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4628 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 14, 3, 2, 2, 1, 1, 10, 2, 1, 1, 17 ]

11

true

Family

Chromatin SPT2

Chromatin_SPT2

2

IPR013257

13,257

Set2 Rpb1 interacting domain

SRI

Domain

5,165

false

The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3K36 methylation with transcript elongation [ ]. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices a...

[ "GO:0006355", "GO:0005694" ]

[ "regulation of DNA-templated transcription", "chromosome" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08236" ]

[ "SRI" ]

[ 5165 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.359", "R-HSA-3214841", "R-MMU-3214841", "R-SCE-3214841", "R-SCE-5693565", "R-SPO-3214841", "R-SPO-5693565" ]

[ "EC:2.1.1.359", "REACTOME:R-HSA-3214841", "REACTOME:R-MMU-3214841", "REACTOME:R-SCE-3214841", "REACTOME:R-SCE-5693565", "REACTOME:R-SPO-3214841", "REACTOME:R-SPO-5693565" ]

7

[ "2a7o", "2c5z", "6nzo", "6px3", "9egz", "9eh0", "9eh2", "9ei1", "9ei2", "9ei3", "9ei4", "9gw2", "9hvo", "9hvq", "9hwg", "9rtn", "9rzc", "9rzd", "9s0u", "9s3g" ]

20

[ "PUB00017167", "PUB00035470", "PUB00039899", "PUB00154376" ]

[ "15798214", "16314571", "16286474", "28100692" ]

[ "A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.", "Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.", "Structure and carboxyl-terminal...

[ 2005, 2005, 2006, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5165 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 8, 8, 15, 4, 1, 8, 1, 1 ]

8

true

Domain

Set2 Rpb1 interacting domain

SRI

8

IPR013258

13,258

Striatin, N-terminal

Striatin_N

Domain

7,570

false

This domain is associated with the N terminus of striatin. Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD ( ) repeat domain [ ]. It acts as a scaffold protein [ ] and is involved in signalling pathways [ , ].

[]

0

[ "PFAM" ]

[ "PF08232" ]

[ "Striatin" ]

[ 7570 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1257604", "R-HSA-2219530", "R-HSA-6811558", "R-HSA-9009391", "R-HSA-9673766", "R-HSA-9700645", "R-HSA-9725370", "R-MMU-1257604", "R-MMU-6811558", "R-MMU-9009391", "R-RNO-1257604", "R-RNO-6811558", "R-RNO-9009391" ]

[ "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-9009391", "REACTOME:R-HSA-9673766", "REACTOME:R-HSA-9700645", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-1257604", "REACTOME:R-MMU-6811558", "REACTOME:R-MMU-9009391", "REACTOME:R-RNO-1257604", "REACTOM...

13

[ "4n6j", "6iur", "7k36" ]

3

[ "PUB00017099", "PUB00017100", "PUB00017160" ]

[ "12610732", "10748158", "15569929" ]

[ "Expression and distribution of phocein and members of the striatin family in neurones of rat peripheral ganglia.", "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain.", "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic acti...

[ 2003, 2000, 2004 ]

3

[]

0

null

[ "Eukaryota" ]

[ 7570 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 7, 5, 18, 10, 1, 16, 1, 1 ]

9

true

Domain

Striatin, N-terminal

Striatin_N

3

IPR013259

13,259

Sulfakinin

Family

273

false

The sulfakinin (SK) family of neuropeptides have only been identified in crustaceans and insects. For most species there is the potential for producing two sulfakinin peptides, one has a short sulfakinin sequence. The function of the sulfakinins is difficult to assess. For the Periplaneta americana (American cockroach)...

[]

0

[ "PFAM" ]

[ "PF08257" ]

[ "Sulfakinin" ]

[ 273 ]

1

[]

0

[]

0

[ "PUB00020387", "PUB00094352" ]

[ "10672025", "17632121" ]

[ "Sulfakinin neuropeptides in a crustacean. Isolation, identification andtissue localization in the tiger prawn Penaeus monodon.", "The drosulfakinin 0 (DSK 0) peptide encoded in the conserved Dsk gene affects adult Drosophila melanogaster crop contractions." ]

[ 2000, 2007 ]

2

[]

0

null

[ "Panarthropoda" ]

[ 273 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Family

Sulfakinin

1

IPR013260

13,260

mRNA splicing factor SYF2

mRNA_splic_SYF2

Family

4,770

false

Proteins in this entry are involved in cell cycle progression and pre-mRNA splicing [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08231", "PTHR13264" ]

[ "SYF2", "" ]

[ 4565, 4432 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-DME-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163", "R-SPO-72163", "R-XTR-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163", "REACTOME:R-SPO-72163", "REACTOME:R-XTR-72163" ]

8

[ "5gm6", "5gmk", "5mps", "5mq0", "5mqf", "5wsg", "5xjc", "5y88", "5ylz", "5yzg", "6bk8", "6exn", "6icz", "6id0", "6id1", "6j6g", "6j6h", "6j6n", "6j6q", "6qdv", "7a5p", "7b9v", "7w59", "7w5a", "7w5b", "8c6j", "8i0u", "8i0v", "8i0w", "8ro0", "8ro1", "8ro2"...

40

[ "PUB00017141", "PUB00017145" ]

[ "11102353", "12384582" ]

[ "Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae.", "Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4770 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 3, 1, 1, 7, 3, 1, 1, 21 ]

12

true

Family

mRNA splicing factor SYF2

mRNA_splic_SYF2

6

IPR013261

13,261

Mitochondrial import inner membrane translocase subunit Tim21

Tim21

Family

4,184

false

Tim21 is an essential component of the TIM23 complex, which mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Tim21 is required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translo...

[ "GO:0030150", "GO:0005744" ]

[ "protein import into mitochondrial matrix", "TIM23 mitochondrial import inner membrane translocase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF08294", "PTHR13032" ]

[ "TIM21", "" ]

[ 4150, 4089 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1268020", "R-HSA-9864848", "R-MMU-9864848", "R-RNO-9864848" ]

[ "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848", "REACTOME:R-RNO-9864848" ]

4

[ "2ciu", "2mf7", "6k7d", "6k7e", "6k7f", "6k8q" ]

6

[ "PUB00017154", "PUB00062936" ]

[ "15797382", "15878866" ]

[ "Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.", "Role of Tim21 in mitochondrial translocation contact sites." ]

[ 2005, 2005 ]

2

[]

0

null

[ "Candidatus Altarchaeum hamiconexum", "Eukaryota" ]

[ 1, 4183 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 1, 4, 2, 1, 5, 4, 1, 1, 3 ]

12

true

Family

Mitochondrial import inner membrane translocase subunit Tim21

Tim21

7

IPR013262

13,262

Outer membrane protein, MIM1/TOM13, mitochondrial

OMP_MIM1/TOM13_mt

Family

1,566

false

The TOM13 family of proteins are mitochondrial outer membrane proteins that mediate the assembly of β-barrel proteins [ ].

[ "GO:0005741" ]

[ "mitochondrial outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF08219", "PTHR28241" ]

[ "TOM13", "" ]

[ 1565, 1393 ]

2

[]

0

[]

0

[ "PUB00016442" ]

[ "15326197" ]

[ "Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota", "Parabacteroides distasonis" ]

[ 1565, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Outer membrane protein, MIM1/TOM13, mitochondrial

OMP_MIM1/TOM13_mt

7

IPR013264

13,264

DNA primase DNAG, catalytic core, N-terminal

DNAG_N

Domain

28,918

false

DNA primase (DNAG) is a a nucleotidyltransferase which synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork. It can also prime the leading strand and has been implicated in cell division [ ]. Primases comprise three domains: a zinc-binding domain at the ...

[]

0

[ "PFAM" ]

[ "PF08275" ]

[ "DNAG_N" ]

[ 28918 ]

1

[ "EC" ]

[ "2.7.7.101" ]

[ "EC:2.7.7.101" ]

1

[ "1dd9", "1dde", "1eqn", "2au3", "3b39", "4e2k", "4edg", "4edk", "4edr", "4edt", "4edv", "4ee1", "5guj", "5vaz", "5w33", "5w34", "5w35", "5w36" ]

18

[ "PUB00001839", "PUB00020176" ]

[ "8294018", "12769857" ]

[ "The Haemophilus influenzae dnaG sequence and conserved bacterial primase motifs.", "Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis." ]

[ 1993, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 27891, 147, 21, 251, 608 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA primase DNAG, catalytic core, N-terminal

DNAG_N

7

IPR013265

13,265

TRI9, Fusarium species

TRI9_FUSspp

Family

29

false

This entry contains putative genes, of 129 bp, from the Trichothecene gene cluster of Fusarium sporotrichioides and Gibberella zeae (Fusarium graminearum) that encode a predicted protein of 43 amino acids whose function is unknown [ , ].

[]

0

[ "PFAM" ]

[ "PF08195" ]

[ "TRI9" ]

[ 29 ]

1

[]

0

[]

0

[ "PUB00017111", "PUB00017163" ]

[ "11352533", "12080147" ]

[ "A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum.", "Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Fusarium" ]

[ 29 ]

1

[]

0

true

Family

TRI9, Fusarium species

TRI9_FUSspp

1

IPR013266

13,266

Tryptophyllin skin active peptide

Tryptophillin

Family

10

false

PdT-3 or Tryptophyllin-3 peptide is a subfamily of the family Tryptophyllin and of the superfamily FSAP (Frog Skin Active Peptide). Originally identified in skin extracts of Neotropical leaf frogs, Phyllomedusa sp. This subfamily has an average length of 13 amino acids. The pharmacological activity of the tryptophyllin...

[]

0

[ "PFAM" ]

[ "PF08248" ]

[ "Tryp_FSAP" ]

[ 10 ]

1

[]

0

[]

0

[ "PUB00017136", "PUB00017143", "PUB00053770" ]

[ "3831963", "14687697", "15134346" ]

[ "Isolation and primary structure determination of amphibian skin tryptophyllins.", "Pachymedusa dacnicolor tryptophyllin-1: structural characterization, pharmacological activity and cloning of precursor cDNA.", "Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including ...

[ 1985, 2004, 2004 ]

3

[]

0

null

[ "Anura" ]

[ 10 ]

1

[]

0

true

Family

Tryptophyllin skin active peptide

Tryptophillin

6

IPR013267

13,267

Hepatitis TT virus, Orf2a

Hepatitis_TTV_Orf2a

Family

66

false

Most isolated ORF2 of TT virus (TTV) encode a 49 amino acid protein (pORF2a) because of an in-frame stop codon. ORF2s isolated from G1 TTV encode a 202 amino acid protein (pORF2ab) [ ].

[]

0

[ "PFAM" ]

[ "PF08197" ]

[ "TT_ORF2a" ]

[ 66 ]

1

[]

0

[]

0

[ "PUB00017098" ]

[ "10963344" ]

[ "Identification of a novel 23kDa protein encoded by putative open reading frame 2 of TT virus (TTV) genotype 1 different from the other genotypes." ]

[ 2000 ]

1

[]

0

null

[ "Anelloviridae" ]

[ 66 ]

1

[]

0

true

Family

Hepatitis TT virus, Orf2a

Hepatitis_TTV_Orf2a

7

IPR013268

13,268

U3 small nucleolar RNA-associated protein 16

UTP16

Family

991

false

This family of proteins is associated with U3 snoRNA [ ]. U3 snoRNA is required for nucleolar processing of pre-18S ribosomal RNA. Proteins in this family include U3 small nucleolar RNA-associated protein 16 (UTP16, also known as Bud21) from S. cerevisiae. Bud21 is a component of small ribosomal subunit (SSU) processos...

[ "GO:0030515", "GO:0006364" ]

[ "snoRNA binding", "rRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08297" ]

[ "U3_snoRNA_assoc" ]

[ 991 ]

1

[]

0

[ "5wlc", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqu", "6lqv", "6nd4", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "7ajt", "7aju", "7d4i", "7d5s", "7d63", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z"...

40

[ "PUB00008496", "PUB00035364", "PUB00153395" ]

[ "12068309", "11452010", "28945246" ]

[ "A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.", "A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae.", "The complete structure of the small-subunit processome." ]

[ 2002, 2001, 2017 ]

3

[]

0

null

[ "Eukaryota" ]

[ 991 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

U3 small nucleolar RNA-associated protein 16

UTP16

9

IPR013269

13,269

Herpesvirus UL2

Herpes_UL2

Family

35

false

This entry contains Orf UL2 of Human cytomegalovirus (HHV-5) (Human herpesvirus 5), which is a short protein of unknown function [ ].

[]

0

[ "PFAM" ]

[ "PF08196" ]

[ "UL2" ]

[ 35 ]

1

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[]

0

[ "PUB00017146" ]

[ "12533697" ]

[ "The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." ]

[ 2003 ]

1

[]

0

null

[ "Cytomegalovirus" ]

[ 35 ]

1

[]

0

true

Family

Herpesvirus UL2

Herpes_UL2

6

IPR013270

13,270

CD47 immunoglobulin-like

CD47_Vset

Domain

1,615

false

This entry represents the V-set like Ig domain found at the N-terminal end of Leukocyte surface antigen CD47 proteins from chordates and CD47-like proteins A38, also known as Protein OPG166, from Poxvirus. Human CD47 is an adhesive protein that mediates cell-to-cell interactions [ , ]. It is involved in signal transduc...

[]

0

[ "PFAM" ]

[ "PF08204" ]

[ "V-set_CD47" ]

[ 1615 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-202733", "R-HSA-216083", "R-HSA-391160", "R-HSA-6798695", "R-MMU-202733", "R-MMU-216083", "R-MMU-391160", "R-MMU-6798695", "R-RNO-202733", "R-RNO-216083", "R-RNO-391160", "R-RNO-6798695", "R-SSC-202733", "R-SSC-216083", "R-SSC-391160", "R-SSC-6798695" ]

[ "REACTOME:R-HSA-202733", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-391160", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-202733", "REACTOME:R-MMU-216083", "REACTOME:R-MMU-391160", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-202733", "REACTOME:R-RNO-216083", "REACTOME:R-RNO-391160", "REACTOME:R-RNO-6...

16

[ "2jjs", "2jjt", "2vsc", "4cmm", "4kjy", "5iwl", "5tz2", "5tzt", "5tzu", "7myz", "7wn8", "7xjf", "7ygg", "8rp8", "8zca" ]

15

[ "PUB00017115", "PUB00017128", "PUB00088077", "PUB00095391", "PUB00103704", "PUB00103705", "PUB00103706", "PUB00103707" ]

[ "8794870", "12124426", "15383453", "8551630", "19004835", "11509594", "32679764", "27742621" ]

[ "Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding.", "Expression of CD47/integrin-associated protein induces death of cultured cerebral cortical neurons.", "Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates ...

[ 1996, 2002, 2005, 1996, 2009, 2001, 2020, 2017 ]

8

[]

[ "IPR037805" ]

0

1

0

[ "Bamfordvirae", "Eumetazoa" ]

[ 108, 1507 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 10, 13 ]

3

true

Domain

CD47 immunoglobulin-like

CD47_Vset

3

IPR013272

13,272

Vps72/YL1, C-terminal

Vps72/YL1_C

Domain

7,513

false

This domain is found at the C terminus in proteins of the Vps72/YL1 family [ , ], in which it represents a proline-rich domain [ ]. These proteins are involved in chromatin remodelling [ , ]. This domain is also found in proteins that do not belong to the Vps72/YL1 family.

[]

0

[ "PFAM", "SMART" ]

[ "PF08265", "SM00993" ]

[ "YL1_C", "YL1_C" ]

[ 7426, 7331 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3214847", "R-HSA-5689603", "R-HSA-5696394", "R-MMU-5689603", "R-MMU-5696394", "R-RNO-5689603", "R-RNO-5696394" ]

[ "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-5689603", "REACTOME:R-HSA-5696394", "REACTOME:R-MMU-5689603", "REACTOME:R-MMU-5696394", "REACTOME:R-RNO-5689603", "REACTOME:R-RNO-5696394" ]

7

[ "6fhs", "6fml", "7zi4", "8av6", "8ets", "8etu", "8etw", "8eu9", "8euf", "8oo7", "8ooc", "8oof", "8oop", "8oor", "8oot", "8qr1", "8qyv", "8qz0", "8x15", "8x19", "8x1c", "8xvg", "8xvt", "9b1d", "9b1e", "9c57", "9c62", "9c9g", "9c9s", "9c9t", "9c9z", "9ca7"...

46

[ "PUB00017178", "PUB00075531", "PUB00075532", "PUB00101224" ]

[ "7702631", "23580526", "15528408", "26974126" ]

[ "Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability.", "A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.", "Acetylation by Tip60 is required for selective histone variant exchange at DNA lesi...

[ 1995, 2013, 2004, 2016 ]

4

[]

0

null

[ "Eukaryota", "Flavobacterium crocinum" ]

[ 7512, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 10, 3, 4, 4, 2, 7, 5, 3, 2, 10 ]

12

true

Domain

Vps72/YL1, C-terminal

Vps72/YL1_C

6

IPR013273

13,273

ADAMTS/ADAMTS-like

Family

28,997

false

This entry includes ADAM-TS and ADAM-TS-like proteins, which are closely related to the ADAM family (A Disintegrin and Metalloproteinase) [ , , ]. ADAM-TS proteases are zinc metalloendopeptidases, most of whose substrates are extracellular matrix (ECM) components, whereas ADAM-TS-like proteins lack a metalloprotease do...

[ "GO:0030198" ]

[ "extracellular matrix organization" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01857" ]

[ "ADAMTSFAMILY" ]

[ 28997 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24", "R-BTA-1650814", "R-BTA-5173214", "R-CEL-5173214", "R-HSA-1474228", "R-HSA-1650814", "R-HSA-5083635", "R-HSA-5173214", "R-HSA-75892", "R-HSA-9845619", "R-HSA-9845621", "R-MMU-1474228", "R-MMU-1650814", "R-MMU-5173214", "R-MMU-75892", "R-RNO-1474228", "R-RNO-5173214" ]

[ "EC:3.4.24", "REACTOME:R-BTA-1650814", "REACTOME:R-BTA-5173214", "REACTOME:R-CEL-5173214", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-HSA-75892", "REACTOME:R-HSA-9845619", "REACTOME:R-HSA-9845621", "REACTOME:R-MMU-1474228...

17

[ "3ghm", "3ghn", "3vn4", "6qig" ]

4

[ "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017286", "PUB00017294", "PUB00085073", "PUB00090139", "PUB00090140", "PUB00098754", "PUB00098761", "PUB00098762", "PUB00098764", "PUB00098765" ]

[ "8995297", "10356395", "10464288", "9390552", "10417273", "11076767", "29885460", "11805097", "15987500", "30905657", "17265492", "32150898", "34268335" ]

[ "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.", "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new fam...

[ 1997, 1999, 1999, 1997, 1999, 2000, 2018, 2002, 2005, 2019, 2007, 2020, 2021 ]

13

[]

[ "IPR013274", "IPR013275", "IPR013276", "IPR013277" ]

0

4

0

[ "Eukaryota" ]

[ 28997 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 86, 18, 57, 64, 69 ]

6

true

Family

ADAMTS/ADAMTS-like

7

IPR013274

13,274

Peptidase M12B, ADAM-TS1

Pept_M12B_ADAM-TS1

Family

758

false

This entry represents the ADAM-TS1 family of metallopeptidases that belong to MEROPS peptidase family M12, subfamily M12B: adamalysin (clan MA). Proteolysis of the extracellular matrix plays a critical role in establishing tissue architecture during development and in tissue degradation in diseases such as cancer, arth...

[ "GO:0008237", "GO:0008270", "GO:0031012" ]

[ "metallopeptidase activity", "zinc ion binding", "extracellular matrix" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01858" ]

[ "ADAMTS1" ]

[ 758 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-HSA-1474228", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214", "R-RNO-5173214" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214", "REACTOME:R-RNO-5173214" ]

7

[]

0

[ "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017286", "PUB00017294" ]

[ "8995297", "10356395", "10464288", "9390552", "10417273" ]

[ "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.", "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new fam...

[ 1997, 1999, 1999, 1997, 1999 ]

5

[ "IPR013273" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 758 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 6, 3 ]

3

true

Family

Peptidase M12B, ADAM-TS1

Pept_M12B_ADAM-TS1

7

IPR013275

13,275

Peptidase M12B, ADAM-TS2

Pept_M12B_ADAM-TS2

Family

851

false

This entry contains members of the ADAM-TS2 family of metallopeptidases that belong to MEROPS peptidase family M12, subfamily M12B: adamalysin (clan MA). Proteolysis of the extracellular matrix plays a critical role in establishing tissue architecture during development and in tissue degradation in diseases such as can...

[ "GO:0008237", "GO:0008270", "GO:0031012" ]

[ "metallopeptidase activity", "zinc ion binding", "extracellular matrix" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01859" ]

[ "ADAMTS2" ]

[ 851 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.14", "R-BTA-1650814", "R-BTA-5173214", "R-HSA-1650814", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-1650814", "R-MMU-5173214" ]

[ "EC:3.4.24.14", "REACTOME:R-BTA-1650814", "REACTOME:R-BTA-5173214", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-1650814", "REACTOME:R-MMU-5173214" ]

8

[]

0

[ "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017284", "PUB00017286", "PUB00017294" ]

[ "8995297", "10356395", "10464288", "9122202", "9390552", "10417273" ]

[ "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.", "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new fam...

[ 1997, 1999, 1999, 1997, 1997, 1999 ]

6

[ "IPR013273" ]

[]

1

0

1

[ "Eukaryota" ]

[ 851 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 3, 3, 2, 1 ]

4

true

Family

Peptidase M12B, ADAM-TS2

Pept_M12B_ADAM-TS2

8

IPR013276

13,276

Peptidase M12B, ADAM-TS5

Pept_M12B_ADAM-TS5

Family

548

false

This entry represents members of the ADAM-TS5 family of metallopeptidases that belong to MEROPS peptidase family M12, subfamily M12B: adamalysin (clan MA), M12.225. Proteolysis of the extracellular matrix plays a critical role in establishing tissue architecture during development and in tissue degradation in diseases ...

[ "GO:0008237", "GO:0008270", "GO:0031012" ]

[ "metallopeptidase activity", "zinc ion binding", "extracellular matrix" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01860" ]

[ "ADAMTS5" ]

[ 548 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1474228", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-1474228", "R-MMU-5173214" ]

[ "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-1474228", "REACTOME:R-MMU-5173214" ]

5

[]

0

[ "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017280", "PUB00017286", "PUB00017294" ]

[ "8995297", "10356395", "10464288", "12392761", "9390552", "10417273" ]

[ "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.", "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new fam...

[ 1997, 1999, 1999, 2002, 1997, 1999 ]

6

[ "IPR013273" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 548 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3 ]

4

true

Family

Peptidase M12B, ADAM-TS5

Pept_M12B_ADAM-TS5

9

IPR013277

13,277

Peptidase M12B, ADAM-TS8

Pept_M12B_ADAM-TS8

Family

1,917

false

This entry contains members of the ADAM-TS8 family of metallopeptidases that belong to MEROPS peptidase family M12, subfamily M12B: adamalysin (clan MA). Proteolysis of the extracellular matrix plays a critical role in establishing tissue architecture during development and in tissue degradation in diseases such as can...

[ "GO:0008237", "GO:0008270", "GO:0031012" ]

[ "metallopeptidase activity", "zinc ion binding", "extracellular matrix" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01861" ]

[ "ADAMTS8" ]

[ 1917 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-HSA-1474228", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

6

[]

0

[ "PUB00017255", "PUB00017264", "PUB00017271", "PUB00017277", "PUB00017286", "PUB00017294" ]

[ "10438512", "8995297", "10356395", "10464288", "9390552", "10417273" ]

[ "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity.", "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.", "Purification and cloning ...

[ 1999, 1997, 1999, 1999, 1997, 1999 ]

6

[ "IPR013273" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1917 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 4, 4 ]

4

true

Family

Peptidase M12B, ADAM-TS8

Pept_M12B_ADAM-TS8

1

IPR013278

13,278

Apoptosis regulator, Bcl-2

Apop_reg_Bcl2

Family

638

false

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr...

[ "GO:0043066" ]

[ "negative regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01863" ]

[ "APOPREGBCL2" ]

[ 638 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-111453", "R-GGA-844455", "R-HSA-111447", "R-HSA-111453", "R-HSA-6785807", "R-HSA-844455", "R-HSA-9018519", "R-HSA-9634638", "R-HSA-9818030", "R-HSA-9824594", "R-MMU-111447", "R-MMU-111453", "R-MMU-844455" ]

[ "REACTOME:R-GGA-111453", "REACTOME:R-GGA-844455", "REACTOME:R-HSA-111447", "REACTOME:R-HSA-111453", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-844455", "REACTOME:R-HSA-9018519", "REACTOME:R-HSA-9634638", "REACTOME:R-HSA-9818030", "REACTOME:R-HSA-9824594", "REACTOME:R-MMU-111447", "REACTOME:R-MM...

13

[ "1g5m", "1gjh", "2xa0", "4man", "5agw", "5agx", "5fcg", "5jsn", "6iwb", "6o0k", "6o0l", "6o0m", "6o0o", "6o0p", "7y90", "7ya5", "8fy1", "8fy2", "8htr", "8hts", "8iql", "8u27", "9o14", "9o15", "9o16" ]

25

[ "PUB00017281", "PUB00017291", "PUB00017301" ]

[ "11341280", "9735050", "12631689" ]

[ "Apoptosis. Death of a monopoly?", "The Bcl-2 protein family: arbiters of cell survival.", "Cellular distribution of Bcl-2 family proteins." ]

[ 2001, 1998, 2003 ]

3

[ "IPR004725" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 10, 628 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 8 ]

3

true

Family

Apoptosis regulator, Bcl-2

Apop_reg_Bcl2

9

IPR013279

13,279

Apoptosis regulator, Bcl-X

Apop_reg_BclX

Family

1,335

false

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr...

[ "GO:0042981" ]

[ "regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01864" ]

[ "APOPREGBCLX" ]

[ 1335 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-111453", "R-GGA-844455", "R-GGA-9648002", "R-HSA-111453", "R-HSA-6785807", "R-HSA-844455", "R-HSA-9648002", "R-HSA-9692913", "R-HSA-9702518", "R-HSA-9818030", "R-MMU-111453", "R-MMU-844455", "R-MMU-9648002", "R-RNO-111453", "R-RNO-844455", "R-RNO-9648002" ]

[ "REACTOME:R-GGA-111453", "REACTOME:R-GGA-844455", "REACTOME:R-GGA-9648002", "REACTOME:R-HSA-111453", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-844455", "REACTOME:R-HSA-9648002", "REACTOME:R-HSA-9692913", "REACTOME:R-HSA-9702518", "REACTOME:R-HSA-9818030", "REACTOME:R-MMU-111453", "REACTOME:R-M...

16

[ "1af3", "1bxl", "1g5j", "1lxl", "1maz", "1pq0", "1pq1", "1r2d", "1r2e", "1r2g", "1r2h", "1r2i", "1ysg", "1ysi", "1ysn", "1ysw", "2b48", "2bzw", "2lp8", "2lpc", "2m03", "2m04", "2me8", "2me9", "2mej", "2o1y", "2o21", "2o22", "2o2m", "2o2n", "2p1l", "2pon"...

132

[ "PUB00015851", "PUB00017281", "PUB00017291", "PUB00017301" ]

[ "12209154", "11341280", "9735050", "12631689" ]

[ "The Bcl2 family: regulators of the cellular life-or-death switch.", "Apoptosis. Death of a monopoly?", "The Bcl-2 protein family: arbiters of cell survival.", "Cellular distribution of Bcl-2 family proteins." ]

[ 2002, 2001, 1998, 2003 ]

4

[ "IPR004725" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1335 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 9, 10, 10 ]

4

true

Family

Apoptosis regulator, Bcl-X

Apop_reg_BclX

2

IPR013280

13,280

Apoptosis regulator, Bcl-W

Apop_reg_BclW

Family

310

false

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr...

[ "GO:0042981" ]

[ "regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01865" ]

[ "APOPREGBCLW" ]

[ 310 ]

1

[]

0

[ "1mk3", "1o0l", "1zy3", "2y6w", "4cim", "4k5a", "4k5b" ]

7

[ "PUB00015851", "PUB00017281", "PUB00017291", "PUB00017301" ]

[ "12209154", "11341280", "9735050", "12631689" ]

[ "The Bcl2 family: regulators of the cellular life-or-death switch.", "Apoptosis. Death of a monopoly?", "The Bcl-2 protein family: arbiters of cell survival.", "Cellular distribution of Bcl-2 family proteins." ]

[ 2002, 2001, 1998, 2003 ]

4

[ "IPR026298" ]

[]

1

0

1

[ "Bilateria" ]

[ 310 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 5 ]

3

true

Family

Apoptosis regulator, Bcl-W

Apop_reg_BclW

8

IPR013281

13,281

Apoptosis regulator, Mcl-1

Apop_reg_Mc1

Family

990

false

Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr...

[]

0

[ "PRINTS" ]

[ "PR01866" ]

[ "APOPREGMCL1" ]

[ 990 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6785807", "R-HSA-9725370" ]

[ "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9725370" ]

2

[ "1wsx", "2jm6", "2kbw", "2mhs", "2nl9", "2nla", "2pqk", "2roc", "2rod", "3d7v", "3io9", "3kj0", "3kj1", "3kj2", "3kz0", "3mk8", "3pk1", "3wix", "3wiy", "4bpi", "4bpj", "4g35", "4hw2", "4hw3", "4hw4", "4oq5", "4oq6", "4wmr", "4zbf", "4zbi", "5c3f", "5c6h"...

109

[ "PUB00017281", "PUB00017291", "PUB00017301" ]

[ "11341280", "9735050", "12631689" ]

[ "Apoptosis. Death of a monopoly?", "The Bcl-2 protein family: arbiters of cell survival.", "Cellular distribution of Bcl-2 family proteins." ]

[ 2001, 1998, 2003 ]

3

[ "IPR026298" ]

[]

1

0

1

[ "Bilateria", "Lymphocystivirus", "bird metagenome" ]

[ 986, 3, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 8, 1, 5 ]

4

true

Family

Apoptosis regulator, Mcl-1

Apop_reg_Mc1

5

IPR013282

13,282

Bcl-2-related protein A1

Bcl2A1

Family

620

false

Bcl-2-related protein A1 is a proapoptotic member of the Bcl-2 family. It retards apoptosis induced by IL-3 deprivation [ ]. It may function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection

[ "GO:0043066" ]

[ "negative regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PRINTS" ]

[ "PR01867" ]

[ "BCL2RLATEDA1" ]

[ 620 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9725371", "R-HSA-9824594" ]

[ "REACTOME:R-HSA-9725371", "REACTOME:R-HSA-9824594" ]

2

[ "2vm6", "2vof", "2vog", "2voh", "2voi", "3i1h", "3mqp", "4zeq", "5uuk", "5uul", "5uup", "5whh", "5whi", "6e3i", "6e3j", "6mbb", "6mbc", "6rjp", "6vo4", "8rpo", "9ew8", "9fky", "9fkz", "9fl0", "9gip", "9giq", "9gir", "9gis", "9git" ]

29

[ "PUB00060393" ]

[ "8562970" ]

[ "A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation." ]

[ 1996 ]

1

[ "IPR026298" ]

[]

1

0

1

[ "Amniota" ]

[ 620 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 11, 3 ]

3

true

Family

Bcl-2-related protein A1

Bcl2A1

3

IPR013284

13,284

Beta-catenin

Family

6,390

false

Three different forms of catenin (designated alpha, beta and gamma) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex [ ]. Beta-catenin forms a cadherin/beta-catenin/alphaE-catenin complex that can tether the tripartite adhesion complex and regulate actin dynamics [ ]. This entry represents the...

[ "GO:0045296", "GO:0007155" ]

[ "cadherin binding", "cell adhesion" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01869", "PTHR45976" ]

[ "BCATNINFAMLY", "" ]

[ 5747, 6369 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-195253", "R-BTA-196299", "R-BTA-201681", "R-BTA-201722", "R-BTA-3134973", "R-BTA-351906", "R-BTA-3769402", "R-BTA-4086398", "R-BTA-418990", "R-BTA-4641262", "R-BTA-5218920", "R-BTA-525793", "R-BTA-5626467", "R-BTA-6798695", "R-BTA-6805567", "R-BTA-6809371", "R-BTA-8951430", ...

[ "REACTOME:R-BTA-195253", "REACTOME:R-BTA-196299", "REACTOME:R-BTA-201681", "REACTOME:R-BTA-201722", "REACTOME:R-BTA-3134973", "REACTOME:R-BTA-351906", "REACTOME:R-BTA-3769402", "REACTOME:R-BTA-4086398", "REACTOME:R-BTA-418990", "REACTOME:R-BTA-4641262", "REACTOME:R-BTA-5218920", "REACTOME:R-BT...

210

[ "1g3j", "1i7w", "1i7x", "1jdh", "1jpp", "1jpw", "1luj", "1m1e", "1qz7", "1t08", "1th1", "1v18", "2bct", "2gl7", "2z6g", "2z6h", "3bct", "3ifq", "3ouw", "3oux", "3sl9", "3sla", "3tx7", "4djs", "4ev8", "4ev9", "4eva", "4evp", "4evt", "4ons", "4r0z", "4r10"...

51

[ "PUB00000237", "PUB00000843", "PUB00000951", "PUB00011781", "PUB00017308", "PUB00017318", "PUB00017323", "PUB00017324", "PUB00071468" ]

[ "7945318", "2261639", "9298899", "11136974", "9425166", "1397690", "11491282", "10679188", "23739176" ]

[ "Molecular cloning reveals alternative splice forms of human alpha(E)-catenin.", "The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.", "Three-dimensional structure of the armadillo repeat region of beta-catenin.", "Crystal structure ...

[ 1994, 1990, 1997, 2000, 1998, 1992, 2001, 2000, 2013 ]

9

[]

0

null

[ "Eukaryota" ]

[ 6390 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 15, 2, 33, 9, 11 ]

6

true

Family

Beta-catenin

2

IPR013287

13,287

Claudin-12

Claudin12

Family

813

false

Zona occludens (ZO), or tight junctions (TJ), are specialised membrane domains found at the most apical region of polarised epithelial and endothelial cells. They create a primary barrier, preventing paracellular transport of solutes, and restricting the lateral diffusion of membrane lipids and proteins, thus maintaini...

[]

0

[ "PRINTS", "PANTHER" ]

[ "PR01872", "PTHR16703" ]

[ "CLAUDIN12", "" ]

[ 800, 809 ]

2

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[]

0

[ "PUB00003085", "PUB00003087", "PUB00004927", "PUB00005988", "PUB00009408", "PUB00017299", "PUB00017303" ]

[ "9647647", "9786950", "9892664", "10370242", "11283726", "11247307", "11517306" ]

[ "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.", "A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts.", "Claudin multigene family encoding four-transmembrane domain protein ...

[ 1998, 1998, 1999, 1999, 2001, 2001, 2001 ]

7

[]

0

null

[ "Vertebrata" ]

[ 813 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 1, 2 ]

4

true

Family

Claudin-12

Claudin12

2

IPR013288

13,288

Cytochrome c oxidase subunit IV

Cyt_c_oxidase_su4

Family

2,507

false

Cytochrome c oxidase (COX) subunit IV is a mitochondrial inner membrane protein that forms part of the 13-subunit COX complex, the terminal oxidase in the mitochondrial electron transport chain. The enzyme catalyses the reaction: 4 ferrocytochrome c + O(2) = 4 ferricytochrome c + 2 H(2)O This polypeptide belongs to a w...

[]

0

[ "PRINTS" ]

[ "PR01873" ]

[ "CYTCOXIDASE4" ]

[ 2507 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-HSA-611105", "R-HSA-9707564", "R-HSA-9837999", "R-HSA-9864848", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9707564", "R-MMU-9864848", "R-RNO-5628897", "R-RNO-611105", "R-RNO-9707564", "R-RNO-9864848" ...

[ "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9864848", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9707564", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-5628897", "REACTOME:R-MMU-611105", "REACTOME:R...

17

[ "1occ", "1oco", "1ocr", "1ocz", "1v54", "1v55", "2dyr", "2dys", "2eij", "2eik", "2eil", "2eim", "2ein", "2occ", "2y69", "2ybb", "2zxw", "3abk", "3abl", "3abm", "3ag1", "3ag2", "3ag3", "3ag4", "3asn", "3aso", "3wg7", "3x2q", "5b1a", "5b1b", "5b3s", "5gpn"...

109

[ "PUB00005218", "PUB00017275" ]

[ "8638158", "10089392" ]

[ "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A.", "Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution." ]

[ 1996, 1999 ]

2

[ "IPR004203" ]

[]

1

0

1

[ "Bilateria" ]

[ 2507 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 3, 6, 4, 9 ]

6

true

Family

Cytochrome c oxidase subunit IV

Cyt_c_oxidase_su4

8

IPR013289

13,289

CBFA2T family

CBFA2T1/2/3

Family

5,903

false

This entry represents the CBFA2T family, whose members include CBFA2T1/2/3. They are transcriptional corepressors which facilitate transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes [ , ].

[ "GO:0003714", "GO:0045892" ]

[ "transcription corepressor activity", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01875", "PTHR10379" ]

[ "ETOFAMILY", "" ]

[ 5412, 5770 ]

2

[ "REACTOME" ]

[ "R-HSA-9827857" ]

[ "REACTOME:R-HSA-9827857" ]

1

[ "1wq6", "2dj8", "2h7b", "2knh", "2kyg", "2od1", "2odd", "2pp4", "4jol", "5ecj", "9de2" ]

11

[ "PUB00017006", "PUB00077026" ]

[ "12559562", "15203199" ]

[ "The ETO (MTG8) gene family.", "The MTG proteins: chromatin repression players with a passion for networking." ]

[ 2003, 2004 ]

2

[]

[ "IPR013290", "IPR013291", "IPR013292", "IPR013293" ]

0

4

0

[ "Eukaryota" ]

[ 5903 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 62, 4, 53, 15, 18 ]

5

true

Family

CBFA2T family

CBFA2T1/2/3

2

IPR013291

13,291

Myeloid transforming gene-related protein-1 (MTGR1)

MTGR1

Family

881

false

Transcriptional activation and repression is required for control of cell proliferation and differentiation during embryonic development and homeostasis in the adult organism. Perturbations of these processes can lead to the development of cancer [ ]. The Eight-Twenty-One (ETO) gene product is able to form complexes wi...

[]

0

[ "PRINTS" ]

[ "PR01877" ]

[ "MTGR1PROTEIN" ]

[ 881 ]

1

[ "REACTOME" ]

[ "R-HSA-9827857" ]

[ "REACTOME:R-HSA-9827857" ]

1

[]

0

[ "PUB00017006", "PUB00017248", "PUB00017256" ]

[ "12559562", "9787195", "11150306" ]

[ "The ETO (MTG8) gene family.", "EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias.", "Multiple regions of ETO cooperate in transcriptional repression." ]

[ 2003, 1998, 2001 ]

3

[ "IPR013289" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 881 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 4 ]

3

true

Family

Myeloid transforming gene-related protein-1 (MTGR1)

MTGR1

1

IPR013292

13,292

Protein CBFA2T3

CBFA2T3

Family

358

false

CBFA2T3 is a transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes [ , ].

[ "GO:0003714", "GO:0045892" ]

[ "transcription corepressor activity", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS" ]

[ "PR01878" ]

[ "MTG16PROTEIN" ]

[ 358 ]

1

[]

0

[]

0

[ "PUB00017006", "PUB00077026" ]

[ "12559562", "15203199" ]

[ "The ETO (MTG8) gene family.", "The MTG proteins: chromatin repression players with a passion for networking." ]

[ 2003, 2004 ]

2

[ "IPR013289" ]

[]

1

0

1

[ "Bilateria" ]

[ 358 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 5 ]

3

true

Family

Protein CBFA2T3

CBFA2T3

9

IPR013293

13,293

Nervy

Family

40

false

Transcriptional activation and repression is required for control of cell proliferation and differentiation during embryonic development and homeostasis in the adult organism. Perturbations of these processes can lead to the development of cancer [ ]. The Eight-Twenty-One (ETO) gene product is able to form complexes wi...

[]

0

[ "PRINTS" ]

[ "PR01879" ]

[ "NERVYPROTEIN" ]

[ 40 ]

1

[]

0

[]

0

[ "PUB00015104", "PUB00017006", "PUB00017256" ]

[ "7498738", "12559562", "11150306" ]

[ "Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue.", "The ETO (MTG8) gene family.", "Multiple regions of ETO cooperate in transcriptional repression." ]

[ 1995, 2003, 2001 ]

3

[ "IPR013289" ]

[]

1

0

1

[ "Schizophora" ]

[ 40 ]

1

[ "Drosophila melanogaster" ]

[ 4 ]

1

true

Family

Nervy

2

IPR013294

13,294

Protein LBH

LBH

Family

959

false

LBH (limb-bud and heart) protein may act as a transcriptional activator in mitogen-activated protein kinase signalling pathway to mediate cellular functions. It has been shown to regulate cardiac gene expression by modulating the combinatorial activities of key cardiac transcription factors, as well as their individual...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PIRSF", "PRINTS" ]

[ "PIRSF008130", "PR01881" ]

[ "LBH", "LBHPROTEIN" ]

[ 818, 952 ]

2

[]

0

[]

0

[ "PUB00077034" ]

[ "17390236" ]

[ "A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway." ]

[ 2008 ]

1

[ "IPR042945" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 959 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 4 ]

4

true

Family

Protein LBH

LBH

3

IPR013295

13,295

Myelin and lymphocyte (MAL) protein

MAL

Family

4,679

false

Myelin is a product of myelinating cells: Schawnn cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). The processes of these myelinating cells wrap around axon segments to form a sheath. This sheath possesses insulating properties, allowing rapid propagation of action ...

[]

0

[ "PRINTS" ]

[ "PR01884" ]

[ "MALPROTEIN" ]

[ 4679 ]

1

[]

0

[]

0

[ "PUB00017245", "PUB00017250", "PUB00017297" ]

[ "9842910", "10339572", "10739088" ]

[ "MAL, a novel integral membrane protein of human T lymphocytes, associates with glycosylphosphatidylinositol-anchored proteins and Src-like tyrosine kinases.", "VIP17/MAL, a lipid raft-associated protein, is involved in apical transport in MDCK cells.", "MAL, a proteolipid in glycosphingolipid enriched domains:...

[ 1998, 1999, 2000 ]

3

[]

0

null

[ "Bilateria" ]

[ 4679 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 11, 6, 16 ]

4

true

Family

Myelin and lymphocyte (MAL) protein

MAL

9

IPR013296

13,296

HSPB1-associated protein 1

HSPB1-associated_protein_1

Family

793

false

The small heat shock proteins of vertebrates are thought to play a major role in the cellular response to stress, and appear to play a role in a range of other physiological activities. Indeed, in response to many forms of stress, including heat, the expression of heat shock proteins is increased, and coincidentally th...

[]

0

[ "PRINTS" ]

[ "PR01886" ]

[ "PASS1" ]

[ 793 ]

1

[]

0

[]

0

[ "PUB00017253" ]

[ "10751411" ]

[ "Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27." ]

[ 2000 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 793 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 5 ]

3

true

Family

HSPB1-associated protein 1

HSPB1-associated_protein_1

1

IPR013297

13,297

Neuropeptide B/W precursor family

Neuropept_BW_pre

Family

844

false

Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified and named preproneuropeptide B and preproneuropeptide W [ , , ]. In humans, each precursor contains a signal sequence and two dibasic cleavage sites. Alternative clea...

[ "GO:0001664" ]

[ "G protein-coupled receptor binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF15180", "PR01888", "PTHR28553" ]

[ "NPBW", "NROPEPTIDEBW", "" ]

[ 836, 804, 831 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-375276", "R-BTA-418594", "R-HSA-375276", "R-HSA-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594", "R-SSC-375276", "R-SSC-418594" ]

[ "REACTOME:R-BTA-375276", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594", "REACTOME:R-SSC-375276", "REACTOME:R-SSC-418594" ]

10

[]

0

[ "PUB00013914", "PUB00013915", "PUB00013916" ]

[ "12130646", "12401809", "12118011" ]

[ "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.", "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.", "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7." ]

[ 2002, 2003, 2002 ]

3

[]

[ "IPR013298", "IPR013299" ]

0

2

0

[ "Vertebrata" ]

[ 844 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 6, 5 ]

4

true

Family

Neuropeptide B/W precursor family

Neuropept_BW_pre

4

IPR013298

13,298

Neuropeptide B precursor

Neuropept_B_pre

Family

494

false

Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified and named preproneuropeptide B and preproneuropeptide W [ , , ]. In humans, each precursor contains a signal sequence and two dibasic cleavage sites. Alternative clea...

[]

0

[ "PRINTS" ]

[ "PR01889" ]

[ "PPNRPEPTIDEB" ]

[ 494 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-375276", "R-BTA-418594", "R-HSA-375276", "R-HSA-418594", "R-MMU-375276", "R-MMU-418594", "R-RNO-375276", "R-RNO-418594" ]

[ "REACTOME:R-BTA-375276", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594" ]

8

[]

0

[ "PUB00013914", "PUB00013915", "PUB00013916" ]

[ "12130646", "12401809", "12118011" ]

[ "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.", "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.", "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7." ]

[ 2002, 2003, 2002 ]

3

[ "IPR013297" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 494 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2 ]

3

true

Family

Neuropeptide B precursor

Neuropept_B_pre

4

IPR013299

13,299

Neuropeptide W precursor

Neuropept_W_pre

Family

124

false

Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified and named preproneuropeptide B and preproneuropeptide W [ , , ]. In humans, each precursor contains a signal sequence and two dibasic cleavage sites. Alternative clea...

[]

0

[ "PRINTS" ]

[ "PR01890" ]

[ "PPNRPEPTIDEW" ]

[ 124 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-375276", "R-HSA-418594", "R-RNO-375276", "R-RNO-418594", "R-SSC-375276", "R-SSC-418594" ]

[ "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-418594", "REACTOME:R-SSC-375276", "REACTOME:R-SSC-418594" ]

6

[]

0

[ "PUB00013914", "PUB00013915", "PUB00013916" ]

[ "12130646", "12401809", "12118011" ]

[ "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.", "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.", "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7." ]

[ 2002, 2003, 2002 ]

3

[ "IPR013297" ]

[]

1

0

1

[ "Amniota" ]

[ 124 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 3 ]

3

true

Family

Neuropeptide W precursor

Neuropept_W_pre

3

IPR013300

13,300

Wnt-7 protein

Wnt7

Family

2,580

false

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions...

[ "GO:0005102", "GO:0007275", "GO:0016055", "GO:0005576" ]

[ "signaling receptor binding", "multicellular organism development", "Wnt signaling pathway", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01891" ]

[ "WNT7PROTEIN" ]

[ 2580 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-3238698", "R-HSA-3238698", "R-HSA-373080", "R-MMU-3238698" ]

[ "REACTOME:R-GGA-3238698", "REACTOME:R-HSA-3238698", "REACTOME:R-HSA-373080", "REACTOME:R-MMU-3238698" ]

4

[ "8tzo", "8tzp" ]

2

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011562", "PUB00013890", "PUB00013894", "PUB00055528" ]

[ "9891778", "10967351", "10733430", "9192851", "10508601", "2279700", "21536746" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "Human dishevelled genes constitute a DHR-containing multigene family.", "Wnt signalling shows its versatility.", "Expression of m...

[ 1998, 2000, 2000, 1997, 1999, 1990, 2011 ]

7

[ "IPR005817" ]

[]

1

0

1

[ "Bilateria", "Lymphocystis disease virus 4" ]

[ 2579, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 5, 6, 8 ]

4

true

Family

Wnt-7 protein

Wnt7

2

IPR013301

13,301

Wnt-8 protein

Wnt8

Family

1,984

false

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions...

[ "GO:0005102", "GO:0007275", "GO:0016055", "GO:0005576" ]

[ "signaling receptor binding", "multicellular organism development", "Wnt signaling pathway", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01892" ]

[ "WNT8PROTEIN" ]

[ 1984 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-3238698", "R-DRE-4641262", "R-HSA-201681", "R-HSA-3238698", "R-HSA-373080", "R-HSA-4641262", "R-MMU-3238698", "R-MMU-4641262" ]

[ "REACTOME:R-DRE-3238698", "REACTOME:R-DRE-4641262", "REACTOME:R-HSA-201681", "REACTOME:R-HSA-3238698", "REACTOME:R-HSA-373080", "REACTOME:R-HSA-4641262", "REACTOME:R-MMU-3238698", "REACTOME:R-MMU-4641262" ]

8

[ "4f0a", "7kc4", "8ctg" ]

3

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011562", "PUB00013890", "PUB00017285", "PUB00055528" ]

[ "9891778", "10967351", "10733430", "9192851", "10508601", "1879349", "21536746" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "Human dishevelled genes constitute a DHR-containing multigene family.", "Wnt signalling shows its versatility.", "Xwnt-8, a Xenop...

[ 1998, 2000, 2000, 1997, 1999, 1991, 2011 ]

7

[ "IPR005817" ]

[]

1

0

1

[ "Bilateria" ]

[ 1984 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 6, 4 ]

4

true

Family

Wnt-8 protein

Wnt8

5

IPR013302

13,302

Wnt-10 protein

Wnt10

Family

1,184

false

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions...

[ "GO:0005102", "GO:0007275", "GO:0016055", "GO:0005576" ]

[ "signaling receptor binding", "multicellular organism development", "Wnt signaling pathway", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01893" ]

[ "WNT10PROTEIN" ]

[ 1184 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-3238698", "R-HSA-3238698", "R-HSA-373080", "R-HSA-381340", "R-MMU-3238698" ]

[ "REACTOME:R-DRE-3238698", "REACTOME:R-HSA-3238698", "REACTOME:R-HSA-373080", "REACTOME:R-HSA-381340", "REACTOME:R-MMU-3238698" ]

5

[]

0

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011562", "PUB00013890", "PUB00017240", "PUB00017266", "PUB00055528" ]

[ "9891778", "10967351", "10733430", "9192851", "10508601", "11350055", "8875992", "21536746" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "Human dishevelled genes constitute a DHR-containing multigene family.", "Wnt signalling shows its versatility.", "WNT10A and WNT6...

[ 1998, 2000, 2000, 1997, 1999, 2001, 1996, 2011 ]

8

[ "IPR005817" ]

[]

1

0

1

[ "Bilateria" ]

[ 1184 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 9, 7, 6 ]

4

true

Family

Wnt-10 protein

Wnt10

1

IPR013304

13,304

Wnt-16 protein

Wnt16

Family

762

false

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions...

[ "GO:0005102", "GO:0007275", "GO:0016055", "GO:0005576" ]

[ "signaling receptor binding", "multicellular organism development", "Wnt signaling pathway", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01895" ]

[ "WNT16PROTEIN" ]

[ 762 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3238698", "R-HSA-373080", "R-MMU-3238698" ]

[ "REACTOME:R-HSA-3238698", "REACTOME:R-HSA-373080", "REACTOME:R-MMU-3238698" ]

3

[]

0

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011562", "PUB00013890", "PUB00017279", "PUB00055528" ]

[ "9891778", "10967351", "10733430", "9192851", "10508601", "10500199", "21536746" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "Human dishevelled genes constitute a DHR-containing multigene family.", "Wnt signalling shows its versatility.", "Oncogenic homeo...

[ 1998, 2000, 2000, 1997, 1999, 1999, 2011 ]

7

[ "IPR005817" ]

[]

1

0

1

[ "Bilateria" ]

[ 762 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 4, 4 ]

4

true

Family

Wnt-16 protein

Wnt16

9

IPR013305

13,305

ABC transporter Tap-like

ABC_Tap-like

Family

675

false

The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembra...

[ "GO:0005524", "GO:1904680", "GO:0015833", "GO:0016020" ]

[ "ATP binding", "peptide transmembrane transporter activity", "peptide transport", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR00958" ]

[ "3a01208" ]

[ 675 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.4.2.14", "R-HSA-1236974", "R-HSA-983170", "R-MMU-1236974", "R-MMU-983170", "R-RNO-1236974", "R-RNO-983170" ]

[ "EC:7.4.2.14", "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-983170", "REACTOME:R-MMU-1236974", "REACTOME:R-MMU-983170", "REACTOME:R-RNO-1236974", "REACTOME:R-RNO-983170" ]

7

[ "5u1d", "8t46", "8t4e", "8t4f", "8t4g", "8t4h", "8t4i", "8t4j", "9n61", "9n62", "9n63", "9n64", "9n65", "9n66", "9o94", "9o9d", "9ocg", "9och", "9oci", "9ocj" ]

20

[ "PUB00072081", "PUB00072082", "PUB00072552" ]

[ "7912468", "11251115", "11441126" ]

[ "Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily.", "Role of the ABC transporter Mdl1 in peptide export from mitochondria.", "The human ATP-binding cassette (ABC) transporter superfamily." ]

[ 1994, 2001, 2001 ]

3

[ "IPR039421" ]

[ "IPR005293" ]

1

0

[ "Opisthokonta" ]

[ 675 ]

1

[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 5, 31, 18, 19, 1 ]

5

true

Family

ABC transporter Tap-like

ABC_Tap-like

5

IPR013307

13,307

Superantigen, staphylococcal/streptococcal toxin, bacterial

Superantigen_bac

Family

1,101

false

The prokaryote Staphylococcus aureus is a well-characterised and specialised human pathogen, expressing a variety of virulence factors to allow successful infection of the host [ ]. Symptoms usually manifest in cases of food poisoning, pyrogenic fever and toxic shock syndrome, and can prove lethal in immunocompromised ...

[]

0

[ "PRINTS", "PRINTS" ]

[ "PR01501", "PR01898" ]

[ "TOXICSSTOXIN", "SAGSUPRFAMLY" ]

[ 345, 1061 ]

2

[]

0

[ "1an8", "1aw7", "1b1z", "1bxt", "1ck1", "1cqv", "1d5m", "1d5x", "1d5z", "1d6e", "1dyq", "1enf", "1esf", "1et6", "1et9", "1eu3", "1eu4", "1ewc", "1f77", "1fnu", "1fnv", "1fnw", "1goz", "1ha5", "1hqr", "1hxy", "1i4g", "1i4h", "1i4p", "1i4q", "1i4r", "1i4x"...

142

[ "PUB00007937", "PUB00011606", "PUB00011608", "PUB00017314" ]

[ "9514739", "10627489", "11544350", "11944185" ]

[ "Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.", "Exotoxins of Staphylococcus aureus.", "Toxic shock syndrome and bacterial superantigens: an update.", "Superantigens: micr...

[ 1998, 2000, 2001, 2002 ]

4

[]

[ "IPR006177", "IPR008375" ]

0

2

0

[ "Bacteria", "Caudoviricetes", "Plasmid pIB485" ]

[ 1093, 7, 1 ]

3

[]

0

true

Family

Superantigen, staphylococcal/streptococcal toxin, bacterial

Superantigen_bac

7

IPR013309

13,309

Wnt inhibitory factor (WIF)-1

Wnt-inh

Family

992

false

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions...

[]

0

[ "PRINTS" ]

[ "PR01901" ]

[ "WIFPROTEIN" ]

[ 992 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-201681", "R-HSA-3772470" ]

[ "REACTOME:R-HSA-201681", "REACTOME:R-HSA-3772470" ]

2

[ "2d3j", "2ygn", "2ygo", "2ygp", "2ygq" ]

5

[ "PUB00011232", "PUB00011233", "PUB00011234", "PUB00011562", "PUB00013890", "PUB00017269", "PUB00055528" ]

[ "9891778", "10967351", "10733430", "9192851", "10508601", "10201374", "21536746" ]

[ "Mechanisms of Wnt signaling in development.", "Wnt signaling function in Alzheimer's disease.", "Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.", "Human dishevelled genes constitute a DHR-containing multigene family.", "Wnt signalling shows its versatility.", "A new secreted ...

[ 1998, 2000, 2000, 1997, 1999, 1999, 2011 ]

7

[]

0

null

[ "Bilateria" ]

[ 992 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 4, 3, 4 ]

5

true

Family

Wnt inhibitory factor (WIF)-1

Wnt-inh

3

IPR013310

13,310

Cysteinyl leukotriene receptor 1

CLT1_recept

Family

611

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine, para-crine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term cla...

[]

0

[ "PRINTS" ]

[ "PR01902" ]

[ "CYSLT1RECPTR" ]

[ 611 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "269", "R-HSA-391906", "R-HSA-416476", "R-HSA-9664535", "R-HSA-9679191", "R-MMU-391906", "R-MMU-416476", "R-RNO-391906", "R-RNO-416476" ]

[ "IUPHAR:269", "REACTOME:R-HSA-391906", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-9664535", "REACTOME:R-HSA-9679191", "REACTOME:R-MMU-391906", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-391906", "REACTOME:R-RNO-416476" ]

9

[ "6rz4", "6rz5" ]

2

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007334", "PUB00007335", "PUB00007336", "PUB00007337", "PUB00017265" ]

[ "2111655", "2830256", "8386361", "8170923", "11093801", "11208650", "10462554", "10851239", "10391245" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: di...

[ 1990, 1988, 1993, 1994, 2000, 2001, 1999, 2000, 1999 ]

9

[ "IPR004071" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 611 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3 ]

3

true

Family

Cysteinyl leukotriene receptor 1

CLT1_recept

7

IPR013311

13,311

Cysteinyl leukotriene receptor 2

CLT2_recept

Family

197

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine, para-crine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term cla...

[]

0

[ "PRINTS" ]

[ "PR01903" ]

[ "CYSLT2RECPTR" ]

[ 197 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "270", "R-HSA-391906", "R-HSA-416476", "R-HSA-418555", "R-HSA-9664535", "R-MMU-391906", "R-MMU-416476", "R-RNO-391906", "R-RNO-416476" ]

[ "IUPHAR:270", "REACTOME:R-HSA-391906", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418555", "REACTOME:R-HSA-9664535", "REACTOME:R-MMU-391906", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-391906", "REACTOME:R-RNO-416476" ]

9

[ "6rz6", "6rz7", "6rz8", "6rz9", "9ixx", "9jh5", "9jh6" ]

7

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007334", "PUB00007335", "PUB00007336", "PUB00007337", "PUB00017306" ]

[ "2111655", "2830256", "8386361", "8170923", "11093801", "11208650", "10462554", "10851239", "10913337" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: di...

[ 1990, 1988, 1993, 1994, 2000, 2001, 1999, 2000, 2000 ]

9

[ "IPR004071" ]

[]

1

0

1

[ "Amniota" ]

[ 197 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1 ]

3

true

Family

Cysteinyl leukotriene receptor 2

CLT2_recept

8

IPR013313

13,313

GPR40 receptor fatty acid

GPR40_recept_FA

Family

374

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups. We use the term clan...

[ "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor signaling pathway", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01905" ]

[ "FATTYACIDR" ]

[ 374 ]

1

[ "GP", "GP", "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2096", "GenProp2098", "225", "R-HSA-381771", "R-HSA-400511", "R-HSA-416476", "R-HSA-434316", "R-HSA-444209", "R-MMU-381771", "R-MMU-400511", "R-MMU-416476", "R-MMU-434316", "R-MMU-444209", "R-RNO-381771", "R-RNO-400511", "R-RNO-416476", "R-RNO-434316", "R-RNO-444209" ]

[ "GP:GenProp2096", "GP:GenProp2098", "IUPHAR:225", "REACTOME:R-HSA-381771", "REACTOME:R-HSA-400511", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-434316", "REACTOME:R-HSA-444209", "REACTOME:R-MMU-381771", "REACTOME:R-MMU-400511", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-434316", "REACTOME:R-MMU-4...

18

[ "8t3v", "9k1c" ]

2

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00017311", "PUB00017317", "PUB00017322" ]

[ "2111655", "2830256", "8386361", "8170923", "9344866", "12496284", "12629551" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity...

[ 1990, 1988, 1993, 1994, 1997, 2003, 2003 ]

7

[ "IPR013312" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 374 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 2 ]

3

true

Family

GPR40 receptor fatty acid

GPR40_recept_FA

4

IPR013314

13,314

Globin, lamprey/hagfish type

Globin_lamprey/hagfish

Family

2,029

false

Globins are haem-containing proteins involved in binding and/or transporting oxygen. They belong to a very large and well studied family that is widely distributed in many organisms [ ]. Globins have evolved from a common ancestor and can be divided into three groups: single-domain globins, and two types of chimeric gl...

[ "GO:0005506", "GO:0019825", "GO:0020037", "GO:0015671" ]

[ "iron ion binding", "oxygen binding", "heme binding", "oxygen transport" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PRINTS", "PANTHER" ]

[ "PR01906", "PTHR46783" ]

[ "FISHGLOBIN", "" ]

[ 1473, 1972 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-203615", "R-DRE-8981607", "R-HSA-203615", "R-HSA-8981607", "R-MMU-203615", "R-MMU-8981607", "R-RNO-203615", "R-RNO-8981607" ]

[ "REACTOME:R-DRE-203615", "REACTOME:R-DRE-8981607", "REACTOME:R-HSA-203615", "REACTOME:R-HSA-8981607", "REACTOME:R-MMU-203615", "REACTOME:R-MMU-8981607", "REACTOME:R-RNO-203615", "REACTOME:R-RNO-8981607" ]

8

[ "1dm1", "1f5o", "1f5p", "1it2", "1it3", "1mba", "1uc3", "1umo", "1urv", "1ury", "1ut0", "1ux9", "1v5h", "2dc3", "2fal", "2fam", "2lhb", "3ag0", "3lhb", "3mba", "4b3w", "4mba", "5mba", "6q6p" ]

24

[ "PUB00016016", "PUB00017305", "PUB00017312", "PUB00017313", "PUB00029465", "PUB00035865", "PUB00035866", "PUB00035867", "PUB00035868", "PUB00035869", "PUB00035870", "PUB00035871", "PUB00035872", "PUB00035873", "PUB00035877", "PUB00055462", "PUB00055463", "PUB00153677" ]

[ "15096613", "10788466", "10378271", "2039605", "12962627", "16600051", "17540514", "11092893", "11481493", "15598488", "16888280", "15598493", "15339940", "15804833", "17084861", "17540516", "17701548", "21495624" ]

[ "Ancestral hemoglobins in Archaea.", "Lamprey hemoglobin. Structural basis of the bohr effect.", "The 2.7 A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect.", "The primary structure of the hemoglobins of a s...

[ 2004, 2000, 1999, 1991, 2003, 2006, 2007, 2001, 2001, 2005, 2006, 2005, 2004, 2004, 2007, 2007, 2007, 2011 ]

18

[]

0

null

[ "Eukaryota" ]

[ 2029 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 4, 3, 3 ]

5

true

Family

Globin, lamprey/hagfish type

Globin_lamprey/hagfish

1

IPR013317

13,317

Chromosomal replication initiator protein DnaA, ATPAse domain

DnaA_dom

Domain

33,201

false

This entry represents the central domain of bacterial DnaA proteins [ , , ] which play an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replica...

[]

0

[ "PFAM" ]

[ "PF00308" ]

[ "Bac_DnaA" ]

[ 33201 ]

1

[]

0

[ "1l8q", "2hcb", "2qgz", "2w58", "2z4r", "2z4s", "3bos", "3r8f", "3sc3", "4m4w", "5he8", "5he9", "5x06", "8btg", "8bv3" ]

15

[ "PUB00000665", "PUB00001793", "PUB00003815", "PUB00005517", "PUB00042952" ]

[ "8110826", "2172087", "1779750", "2558436", "16882985" ]

[ "The initiator protein DnaA: evolution, properties and function.", "Nucleotide sequence of a Proteus mirabilis DNA fragment homologous to the 60K-rnpA-rpmH-dnaA-dnaN-recF-gyrB region of Escherichia coli.", "Structure and function of DnaA and the DnaA-box in eubacteria: evolutionary relationships of bacterial re...

[ 1994, 1990, 1991, 1989, 2006 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 32395, 77, 7, 21, 701 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Chromosomal replication initiator protein DnaA, ATPAse domain

DnaA_dom

7

IPR013320

13,320

Concanavalin A-like lectin/glucanase domain superfamily

ConA-like_dom_sf

Homologous_superfamily

651,999

false

This superfamily represents the concanavalin A-like domain, which has a sandwich structure of 12-14 β-strands in two sheets with a complex topology. Proteins containing this domain include: Legume lectins Glycosyl hydrolases family 16 Galectin (animal S-lectin) Laminin G-like module Pentraxin Clostridium neurotoxins Ex...

[]

0

[ "SSF" ]

[ "SSF49899" ]

[ "" ]

[ 651999 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-140837", "R-BTA-140875", "R-BTA-159740", "R-BTA-159763", "R-BTA-159782", "R-BTA-202733", "R-BTA-204005", "R-BTA-216083", "R-BTA-3000178", "R-BTA-3134975", "R-BTA-381426", "R-BTA-5694530", "R-BTA-8951664", "R-BTA-8957275", "R-BTA-9755511", "R-BTA-983168", "R-C...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-140837", "REACTOME:R-BTA-140875", "REACTOME:R-BTA-159740", "REACTOME:R-BTA-159763", "REACTOME:R-BTA-159782", "REACTOME:R-BTA-202733", "REACTOME:R-BTA-204005", "REACTOME:R-BTA-216083", "REACTOME:R-BTA-3000178", "REACTOME:R-BTA-3134975", "REACTOME:R-BTA-3...

432

[ "1a39", "1a3k", "1a78", "1a8d", "1af9", "1ajk", "1ajo", "1apn", "1avb", "1ax0", "1ax1", "1ax2", "1axk", "1axy", "1axz", "1azd", "1b09", "1bcx", "1bjq", "1bk1", "1bkz", "1bqp", "1bvv", "1bxh", "1byh", "1bzw", "1c1f", "1c1l", "1c4r", "1c57", "1c5h", "1c5i"...

2,504

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1322, 122582, 507415, 16564, 4116 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 590, 145, 2503, 292, 1, 894, 612, 39, 533, 848, 15, 13, 571 ]

13

true

Homologous_superfamily

Concanavalin A-like lectin/glucanase domain superfamily

ConA-like_dom_sf

2

IPR013321

13,321

Arc-type ribbon-helix-helix

Arc_rbn_hlx_hlx

Homologous_superfamily

67,520

false

This superfamily represents a domain with a ribbon-helix-helix topology consisting of four helices in an open array of two hairpins. This domain is found in Mnt and Arc, two structurally homologous repressors encoded by bacteriophage P22 [ , ]. This entry also includes nickel-responsive regulator [ ] and protein CopG [...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "CATHGENE3D" ]

[ "G3DSA:1.10.1220.10" ]

[ "" ]

[ 67520 ]

1

[]

0

[ "1arq", "1arr", "1b01", "1b28", "1baz", "1bdt", "1bdv", "1ea4", "1irq", "1mnt", "1myk", "1myl", "1nla", "1p94", "1par", "1q5v", "1qtg", "1u9p", "1x93", "1xrx", "1y9b", "2ay0", "2ba3", "2bj1", "2bj3", "2bj7", "2bj8", "2bj9", "2bnw", "2bnz", "2bsq", "2ca9"...

93

[ "PUB00001322", "PUB00014001", "PUB00017238", "PUB00041555" ]

[ "9857196", "7999761", "12646376", "16945905" ]

[ "The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator.", "Solution structure of dimeric Mnt repressor (1-76).", "Role of an N(cap) residue in determining the stability and operator-binding affinity of Arc repressor.", "NikR-operator complex structure and the mec...

[ 1998, 1994, 2003, 2006 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 4126, 61847, 61, 369, 6, 1111 ]

6

[ "Escherichia coli (strain K12)" ]

[ 8 ]

1

true

Homologous_superfamily

Arc-type ribbon-helix-helix

Arc_rbn_hlx_hlx

6

IPR013324

13,324

RNA polymerase sigma factor, region 3/4-like

RNA_pol_sigma_r3/r4-like

Homologous_superfamily

464,884

false

This entry represents regions 3 and 4 (or sigma3 and sigma4 domains) found in several sigma factors, often in conjunction with the sigma2 domain ( ). Both regions 3 and 4 are present in Sigma70 [ ], Sigma28 (FliA), and SigA [ ], while region4 is also found in SigmaF [ ] and RpoE. Regions 3 and 4 have a nucleotide-bindi...

[]

0

[ "SSF" ]

[ "SSF88659" ]

[ "" ]

[ 464884 ]

1

[]

0

[ "1iw7", "1ku2", "1ku3", "1ku7", "1l0o", "1l9u", "1l9z", "1or7", "1rio", "1rp3", "1s7o", "1sc5", "1smy", "1tlh", "1tty", "1xsv", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2h27", "2lfw", "2o8x", "2p7v", "2q1z", "2z2s", "3dxj", "3eql", "3hug"...

407

[ "PUB00000061", "PUB00000942", "PUB00002181", "PUB00004340", "PUB00010042", "PUB00011848", "PUB00088319" ]

[ "3052291", "8858155", "1597408", "3092189", "11931761", "11955433", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "...

[ 1988, 1996, 1992, 1986, 2002, 2002, 2015 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3098, 449981, 5474, 1132, 5199 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 7, 23, 39 ]

4

true

Homologous_superfamily

RNA polymerase sigma factor, region 3/4-like

RNA_pol_sigma_r3/r4-like

2

IPR013325

13,325

RNA polymerase sigma factor, region 2

RNA_pol_sigma_r2

Homologous_superfamily

442,635

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003700", "GO:0006352", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "SSF" ]

[ "SSF88946" ]

[ "" ]

[ 442635 ]

1

[]

0

[ "1h3l", "1iw7", "1ku2", "1l0o", "1l9u", "1l9z", "1or7", "1rp3", "1sc5", "1sig", "1smy", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2mao", "2map", "2o7g", "2q1z", "2z2s", "3dxj", "3eql", "3iyd", "3les", "3lev", "3mzy", "3ugo", "3ugp", "3wod"...

388

[ "PUB00000061", "PUB00000942", "PUB00010042" ]

[ "3052291", "8858155", "11931761" ]

[ "Structure and function of bacterial sigma factors.", "Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.", "Structure of the bacterial RNA polymerase promoter specificity sigma subunit." ]

[ 1988, 1996, 2002 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 22, 432129, 5428, 482, 4574 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 22, 6, 26, 51 ]

4

true

Homologous_superfamily

RNA polymerase sigma factor, region 2

RNA_pol_sigma_r2

3

IPR013328

13,328

6-phosphogluconate dehydrogenase, domain 2

6PGD_dom2

Homologous_superfamily

277,546

false

This superfamily represents a multi-helical domain found in several NAD or NADP-utilizing dehydrogenases, including 6-phosphogluconate dehydrogenase [ ], classes I and II ketol-acid reductoisomerases [ ], L-3-hydroxyacyl CoA dehydrogenase [ ], UDP-glucose dehydrogenase [ ], glycerol-3-phosphate dehydrogenase [ ], ketop...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.10.1040.10" ]

[ "" ]

[ 277546 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "1.1.1", "R-BTA-5661270", "R-BTA-70895", "R-CEL-1483166", "R-CEL-70895", "R-CEL-71336", "R-CEL-77310", "R-CEL-77346", "R-CEL-77348", "R-CEL-77350", "R-CEL-77352", "R-CEL-9837999", "R-DDI-70895", "R-DDI-71336", "R-DME-1483166", "R-DME-70895", "R-DME-71336", "R-DRE-1483166", "R-HSA...

[ "EC:1.1.1", "REACTOME:R-BTA-5661270", "REACTOME:R-BTA-70895", "REACTOME:R-CEL-1483166", "REACTOME:R-CEL-70895", "REACTOME:R-CEL-71336", "REACTOME:R-CEL-77310", "REACTOME:R-CEL-77346", "REACTOME:R-CEL-77348", "REACTOME:R-CEL-77350", "REACTOME:R-CEL-77352", "REACTOME:R-CEL-9837999", "REACTOME:...

60

[ "1bg6", "1dli", "1dlj", "1evy", "1evz", "1f0y", "1f12", "1f14", "1f17", "1i36", "1il0", "1jdj", "1ks9", "1lj8", "1lsj", "1lso", "1m2w", "1m66", "1m67", "1m75", "1m76", "1n1e", "1n1g", "1pgj", "1pgn", "1pgo", "1pgp", "1pgq", "1qmg", "1txg", "1vpd", "1wp4"...

293

[ "PUB00016267", "PUB00021840", "PUB00034452", "PUB00034453", "PUB00034454", "PUB00034455", "PUB00034456", "PUB00034457", "PUB00085448", "PUB00153317" ]

[ "9665174", "11451959", "16803886", "16322583", "15898741", "16460752", "15966718", "16608840", "23260659", "30970244" ]

[ "Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase.", "Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme.", "Importance in catalysis of the 6-phosphate-binding ...

[ 1998, 2001, 2006, 2005, 2005, 2006, 2005, 2006, 2013, 2019 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3314, 209334, 61765, 114, 3019 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 67, 12, 23, 27, 14, 37, 16, 20, 37, 33, 12, 7, 126 ]

13

true

Homologous_superfamily

6-phosphogluconate dehydrogenase, domain 2

6PGD_dom2

8

IPR013332

13,332

Ketopantoate reductase, N-terminal domain

KPR_N

Domain

38,003

false

This entry represents the N-terminal domain of KPR and related proteins, including ketoisovalerate reductase. This domain contains an α/β-fold of the Rossmann type. Ketopantoate reductase (KPR; ), also known as 2-dehydropantoate 2-reductase or ApbA/PanE, catalyses the NADPH-dependent reduction of ketopantoate to pantoa...

[]

0

[ "PFAM" ]

[ "PF02558" ]

[ "ApbA" ]

[ 38003 ]

1

[ "EC", "METACYC" ]

[ "1.1.1.169", "PWY-6654" ]

[ "EC:1.1.1.169", "METACYC:PWY-6654" ]

2

[ "1bg6", "1ks9", "1yjq", "1yon", "2ew2", "2ofp", "2qyt", "3ego", "3g17", "3ghy", "3hn2", "3hwr", "3i83", "3wfi", "3wfj", "4ol9", "4s3m", "4yca", "5ayv", "5hws", "5x20", "5zik", "5zix", "6k1r", "8iwg", "8iwq", "8ix9", "8ixh", "8ixm", "8wl1", "8wl3", "8wl4"...

32

[ "PUB00020970", "PUB00020974", "PUB00028857", "PUB00104842" ]

[ "9488683", "9721324", "11724562", "25946571" ]

[ "ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway.", "The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium.", "Crystal structure of Escher...

[ 1998, 1998, 2001, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 690, 28587, 8349, 377 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 7, 2, 3 ]

4

true

Domain

Ketopantoate reductase, N-terminal domain

KPR_N

2

IPR013333

13,333

Ryanodine receptor

Ryan_recept

Family

6,437

false

Ryanodine receptors are involved in communication between transverse-tubules and the sarcoplamic reticulum of cardiac and skeletal muscle. The proteins function as a Ca 2+ -release channels following depolarisation of transverse-tubules [ ]. The function is modulated by Ca 2+ , Mg2+, ATP and calmodulin. Deficiency in t...

[ "GO:0005219", "GO:0006816" ]

[ "ryanodine-sensitive calcium-release channel activity", "calcium ion transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS" ]

[ "PR00795" ]

[ "RYANODINER" ]

[ 6437 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2672351", "R-HSA-5578775", "R-MMU-2672351", "R-MMU-5578775", "R-RNO-2672351", "R-RNO-5578775" ]

[ "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-5578775", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-5578775", "REACTOME:R-RNO-2672351", "REACTOME:R-RNO-5578775" ]

6

[ "2mc2", "2xoa", "3hsm", "3ila", "3im5", "3im6", "3im7", "3j8h", "3qr5", "4i0y", "4i1e", "4i2s", "4i37", "4i3n", "4i6i", "4i7i", "4i8m", "4jkq", "4kei", "4kej", "4kek", "4l4h", "4l4i", "4uwa", "4uwe", "5c30", "5c33", "5gky", "5gkz", "5gl0", "5gl1", "5go9"...

216

[ "PUB00001957", "PUB00002597", "PUB00002638" ]

[ "7829078", "2298749", "1645727" ]

[ "Mutation screening of the RYR1 gene in malignant hyperthermia: detection of a novel Tyr to Ser mutation in a pedigree with associated central cores.", "Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.", "Unique...

[ 1994, 1990, 1991 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6436, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 52, 7, 20, 11, 14 ]

6

true

Family

Ryanodine receptor

Ryan_recept

5

IPR013335

13,335

Trp repressor, bacterial

Trp_repress_bac

Family

2,112

false

The Trp repressor (TrpR) binds to at least five operators in the Escherichia coli genome, repressing gene expression. The operators at which it binds vary considerably in DNA sequence and location within the promoter; when bound to the Trp operon it recognises the sequence 5'-ACTAGT-3' and acts to prevent the initiatio...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00475", "PIRSF003196", "PTHR38025", "TIGR01321" ]

[ "Trp_repressor", "Trp_repressor", "", "TrpR" ]

[ 1696, 1746, 2112, 1821 ]

4

[ "GP" ]

[ "GenProp0037" ]

[ "GP:GenProp0037" ]

1

[ "1co0", "1jhg", "1mi7", "1rcs", "1tro", "1trr", "1wrp", "1wrs", "1wrt", "1zt9", "2oz9", "2xdi", "3ssw", "3ssx", "3wrp", "5tm0", "6ejw", "6ejz", "6ekp", "6elb", "6elf", "6elg", "6eni", "6enn", "6f7f", "6f7g", "6f9k", "6fal", "6st6", "6st7", "7os9" ]

31

[ "PUB00013953" ]

[ "12475235" ]

[ "Trp repressor-operator binding: NMR and electrophoretic mobility shift studies of the effect of DNA sequence and corepressor binding on two Trp repressor-operator complexes." ]

[ 2002 ]

1

[ "IPR000831" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2107, 5 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Trp repressor, bacterial

Trp_repress_bac

8

IPR013341

13,341

Mandelate racemase, N-terminal domain

Mandelate_racemase_N

Domain

71,616

false

This entry represents the N-terminal domain in mandelate racemase enzymes, including L-rhamnonate dehydratase, D-galactonate dehydratase and related proteins. These enzymes share a bidomain structure containing a capping domain and a C-terminal barrel domain. The N-terminal domain forms part of the capping domain [ ]. ...

[]

0

[ "PFAM" ]

[ "PF02746" ]

[ "MR_MLE_N" ]

[ 71616 ]

1

[ "EC", "GP", "GP" ]

[ "4.2.1", "GenProp1242", "GenProp1566" ]

[ "EC:4.2.1", "GP:GenProp1242", "GP:GenProp1566" ]

3

[ "1bkh", "1bqg", "1dtn", "1f9c", "1jpd", "1jpm", "1mdl", "1mdr", "1mns", "1mra", "1muc", "1nu5", "1r0m", "1rvk", "1sja", "1sjb", "1sjc", "1sjd", "1tkk", "1wue", "1wuf", "1xpy", "1xs2", "1yey", "2chr", "2fkp", "2gdq", "2gge", "2ggg", "2ggh", "2ggi", "2ggj"...

258

[ "PUB00047672", "PUB00069767" ]

[ "18754693", "15581566" ]

[ "Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.", "Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity." ]

[ 2008, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Oenococcus phage fOg30", "unclassified sequences" ]

[ 2454, 62244, 5594, 1, 1323 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 2, 5, 5, 1, 3, 9 ]

7

true

Domain

Mandelate racemase, N-terminal domain

Mandelate_racemase_N

4

IPR013342

13,342

Mandelate racemase, C-terminal domain

Mandelate_racemase_C

Domain

91,854

false

This entry represents the C-terminal domain in Mandelate racemase related proteins. L-rhamnonate dehydratase (RhamD; ) catalyses the Mg2+-dependent dehydration of L-rhamnonate (6-deoxy-L-mannonate) to 2-keto-3-deoxy-L-rhamnonate (KDR) via a syn-dehydration mechanism [ ]. The enzyme displays promiscuous substrate specif...

[]

0

[ "PFAM", "SMART" ]

[ "PF13378", "SM00922" ]

[ "MR_MLE_C", "MR_MLE" ]

[ 91828, 88855 ]

2

[ "EC" ]

[ "4.2.1" ]

[ "EC:4.2.1" ]

1

[ "1bkh", "1bqg", "1dtn", "1ec7", "1ec8", "1ec9", "1ecq", "1f9c", "1fhu", "1fhv", "1jct", "1jdf", "1jpd", "1jpm", "1mdl", "1mdr", "1mns", "1mra", "1muc", "1nu5", "1r0m", "1r6w", "1rvk", "1sja", "1sjb", "1sjc", "1sjd", "1tkk", "1tzz", "1wue", "1wuf", "1xpy"...

301

[ "PUB00003121", "PUB00004081", "PUB00005187", "PUB00005404", "PUB00047672" ]

[ "8277241", "2215699", "7545940", "8256284", "18754693" ]

[ "Analysis of genome instability in Streptomyces ambofaciens.", "Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous.", "Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.", "On the origin of enzymatic species.", ...

[ 1993, 1990, 1994, 1993, 2008 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2796, 78971, 8315, 2, 1770 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 2, 7, 3, 2, 5, 19 ]

7

true

Domain

Mandelate racemase, C-terminal domain

Mandelate_racemase_C

5

IPR013343

13,343

CRISPR-associated protein Cas4

CRISPR-assoc_prot_Cas4

Family

4,841

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. This entry represents the Cas4 family of proteins. Cas4 proteins resembles the RecB family of exonucleases ( ) and contains a cysteine-rich motif in...

[]

0

[ "NCBIFAM" ]

[ "TIGR00372" ]

[ "cas4" ]

[ 4841 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "3.1.12.1", "GenProp0021", "GenProp0313", "GenProp0317", "GenProp0319", "GenProp0320", "GenProp0469", "GenProp0768", "GenProp0922" ]

[ "EC:3.1.12.1", "GP:GenProp0021", "GP:GenProp0313", "GP:GenProp0317", "GP:GenProp0319", "GP:GenProp0320", "GP:GenProp0469", "GP:GenProp0768", "GP:GenProp0922" ]

9

[ "4ic1", "4r5q", "7mi4", "7mi5", "7mi9", "7mib", "7mid", "8d3l", "8d3m", "8d3p", "8d3q" ]

11

[ "PUB00014786", "PUB00020736", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00063905", "PUB00071890" ]

[ "11788711", "15972856", "17442114", "17379808", "16545108", "21699496", "23056615", "24459147" ]

[ "A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis.", "Identification of novel restriction endonuclease-like fold families among hypothetical proteins.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides...

[ 2002, 2005, 2007, 2007, 2006, 2011, 2012, 2014 ]

8

[]

0

null

[ "Alveolata", "Archaea", "Bacteria", "unclassified sequences" ]

[ 2, 702, 4062, 75 ]

4

[]

0

true

Family

CRISPR-associated protein Cas4

CRISPR-assoc_prot_Cas4

6

IPR013344

13,344

Ribonucleotide reductase, adenosylcobalamin-dependent

RNR_NrdJ/NrdZ

Family

13,076

false

Ribonucleotide reductase (also known as ribonucleoside-diphosphate reductase) catalyses the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides providing the precursors necessary for DNA synthesis. Three main classes of ribonucleotide reductases (RNR) have been discovered that depend on differen...

[ "GO:0000166", "GO:0004748", "GO:0031419" ]

[ "nucleotide binding", "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "cobalamin binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR02504", "cd02888" ]

[ "NrdJ_Z", "RNR_II_dimer" ]

[ 12913, 12687 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.17.4.1", "GenProp0290", "PWY-6545", "PWY-7184", "PWY-7198", "PWY-7210", "PWY-7220", "PWY-7222", "PWY-7226", "PWY-7227" ]

[ "EC:1.17.4.1", "GP:GenProp0290", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7198", "METACYC:PWY-7210", "METACYC:PWY-7220", "METACYC:PWY-7222", "METACYC:PWY-7226", "METACYC:PWY-7227" ]

10

[ "1xje", "1xjf", "1xjg", "1xjj", "1xjk", "1xjm", "1xjn", "3o0n", "3o0o", "3o0q", "7b9p", "7b9q" ]

12

[ "PUB00016697", "PUB00020749", "PUB00020776", "PUB00020792", "PUB00060768" ]

[ "6986368", "9012808", "8990160", "9391052", "15158709" ]

[ "The purification and characterization of an adenosylcobalamin-dependent ribonucleoside diphosphate reductase from Corynebacterium nephridii.", "Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes?", "The B12-dependent ribonucleotide reductase from the...

[ 1980, 1997, 1997, 1997, 2004 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 828, 11807, 31, 75, 335 ]

5

[]

0

true

Family

Ribonucleotide reductase, adenosylcobalamin-dependent

RNR_NrdJ/NrdZ

7

IPR013345

13,345

Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent

RTP_Rdtase_AdoCbl-dep

Family

1,058

false

This entry represents a group of adenosylcobalamin (AdoCbl or coenzymeB12)-dependent ribonucleotide reductases (RNR) related to the characterised species from Lactococcus leichmannii [ ]. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting ste...

[ "GO:0000166", "GO:0004748", "GO:0008998", "GO:0031419", "GO:0006260" ]

[ "nucleotide binding", "ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor", "ribonucleoside-triphosphate reductase (thioredoxin) activity", "cobalamin binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02505" ]

[ "RTPR" ]

[ 1058 ]

1

[ "EC", "GP" ]

[ "1.17.4.2", "GenProp0290" ]

[ "EC:1.17.4.2", "GP:GenProp0290" ]

2

[ "1l1l" ]

1

[ "PUB00020745" ]

[ "8397403" ]

[ "Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "bioreactor metagenome" ]

[ 685, 13, 358, 2 ]

4

[]

0

true

Family

Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent

RTP_Rdtase_AdoCbl-dep

4

IPR013346

13,346

Ribonucleotide reductase, class I, alpha subunit, C-terminal

NrdE_NrdA_C

Domain

30,309

false

This entry represents the C-terminal region of the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on...

[]

0

[ "PROSITE", "NCBIFAM" ]

[ "PS00089", "TIGR02506" ]

[ "RIBORED_LARGE", "NrdE_NrdA" ]

[ 28152, 29360 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.17.4.1", "GenProp0289", "GenProp1191", "PWY-6545", "PWY-7184", "PWY-7198", "PWY-7210", "PWY-7220", "PWY-7222", "PWY-7226", "PWY-7227", "R-CEL-499943", "R-DDI-499943", "R-DME-499943", "R-DRE-499943", "R-HSA-499943", "R-HSA-5213460", "R-HSA-9609690", "R-HSA-9610379", "R-HSA-96...

[ "EC:1.17.4.1", "GP:GenProp0289", "GP:GenProp1191", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7198", "METACYC:PWY-7210", "METACYC:PWY-7220", "METACYC:PWY-7222", "METACYC:PWY-7226", "METACYC:PWY-7227", "REACTOME:R-CEL-499943", "REACTOME:R-DDI-499943", "REACTOME:R-DME-499943", "R...

23

[ "1pem", "1peo", "1peq", "1peu", "1r1r", "1rlr", "1zyz", "1zzd", "2bq1", "2cvs", "2cvt", "2cvu", "2cvv", "2cvw", "2cvx", "2cvy", "2eud", "2r1r", "2wgh", "2x0x", "2xak", "2xap", "2xav", "2xaw", "2xax", "2xay", "2xaz", "2xo4", "2xo5", "2zlf", "2zlg", "3hnc"...

129

[ "PUB00005954", "PUB00020744", "PUB00020990" ]

[ "8052308", "11807048", "8820648" ]

[ "Structure of ribonucleotide reductase protein R1.", "Aerobic-type ribonucleotide reductase in the anaerobe Bacteroides fragilis.", "Promoter identification and expression analysis of Salmonella typhimurium and Escherichia coli nrdEF operons encoding one of two class I ribonucleotide reductases present in both ...

[ 1994, 2002, 1996 ]

3

[ "IPR000788" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 226, 20730, 6628, 2319, 406 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 2, 1, 2, 9, 3, 1, 5, 4, 2, 1, 11 ]

13

true

Domain

Ribonucleotide reductase, class I, alpha subunit, C-terminal

NrdE_NrdA_C

4

IPR013347

13,347

Tetrahydromethanopterin S-methyltransferase, F subunit

MeTrfase_F_su

Domain

231

false

Many archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This domain is mostly found in MtrF, where it covers the entire length of the protein. This polypeptide is one of eight subunits of the N5-methyltetrahydromethanopterin: coenzyme M methyltransfera...

[ "GO:0030269", "GO:0015948", "GO:0016020" ]

[ "tetrahydromethanopterin S-methyltransferase activity", "methanogenesis", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "NCBIFAM" ]

[ "PF09472", "TIGR02507" ]

[ "MtrF", "MtrF" ]

[ 227, 231 ]

2

[ "EC", "GP", "GP" ]

[ "7.2.1.4", "GenProp0288", "GenProp0722" ]

[ "EC:7.2.1.4", "GP:GenProp0288", "GP:GenProp0722" ]

3

[ "8q3v", "8q54" ]

2

[ "PUB00005738", "PUB00020728", "PUB00020729" ]

[ "7737157", "15466049", "15353801" ]

[ "The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits.", "Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis.", "Reverse methanogenesi...

[ 1995, 2004, 2004 ]

3

[]

0

null

[ "Archaea", "Cylicocyclus nassatus", "ecological metagenomes" ]

[ 225, 1, 5 ]

3

[]

0

true

Domain

Tetrahydromethanopterin S-methyltransferase, F subunit

MeTrfase_F_su

9

IPR013348

13,348

Type 3 secretion system chaperone YscG/PscG

T3SS_YscG_PscG

Family

167

false

YscG is a molecular chaperone for YscE, where both are part of the type III secretion system that in Yersinia is designated Ysc (Yersinia secretion). The secretion system delivers effector proteins, designated Yops (Yersinia outer proteins), in Yersinia [ , , ]. This entry family includes YscG from Yersinia, and simila...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09477", "TIGR02508" ]

[ "Type_III_YscG", "type_III_yscG" ]

[ 167, 153 ]

2

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "2p58", "2uwj", "3ph0" ]

3

[ "PUB00048615", "PUB00049490", "PUB00106879", "PUB00151528" ]

[ "18281060", "16115870", "35861543", "29458689" ]

[ "Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG.", "The PscE-PscF-PscG complex controls type III secretion needle biogenesis in Pseudomonas aeruginosa.", "Secreted in a Type III Secretion System-Dependent Man...

[ 2008, 2005, 2022, 2018 ]

4

[]

0

null

[ "Bacteria" ]

[ 167 ]

1

[]

0

true

Family

Type 3 secretion system chaperone YscG/PscG

T3SS_YscG_PscG

3

IPR013349

13,349

Type III secretion system effector YopR

T3SS_YopR

Family

142

false

Proteins in this entry are type III secretion system effectors, named differently in different species and designated YopR in Yersinia and AscH in Aeromonas salmonicida subsp. salmonicida [ , ]. Yersinia employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mam...

[ "GO:0030254", "GO:0030257" ]

[ "protein secretion by the type III secretion system", "type III protein secretion system complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "NCBIFAM" ]

[ "PF09025", "TIGR02509" ]

[ "T3SS_needle_reg", "type_III_yopR" ]

[ 142, 125 ]

2

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "1z21" ]

1

[ "PUB00021003", "PUB00021004", "PUB00035493", "PUB00106696" ]

[ "10209737", "8709853", "15930010", "24119189" ]

[ "Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu.", "Mutational analysis of the Yersinia enterocolitica virC operon: characterization of yscE, F, G, I, J, K required for Yop secretion and yscH encoding YopR.", "Crystal structure of the protease-resistant core do...

[ 1999, 1995, 2005, 2014 ]

4

[]

0

null

[ "Bacteria" ]

[ 142 ]

1

[]

0

true

Family

Type III secretion system effector YopR

T3SS_YopR

7

IPR013350

13,350

Ribonucleotide reductase alpha chain

RNR_alpha

Family

862

false

Proteins in this entry represent a small clade of ribonucleoside-diphosphate reductase alpha chains which are sufficiently divergent from the usual Class I ribonucleotide reductase (RNR) alpha chains (NrdE or NrdA, ) to form a distinct group. The genes from Thermus thermophilus, Dichelobacter and Salinibacter are adjac...

[]

0

[ "NCBIFAM" ]

[ "TIGR02510" ]

[ "NrdE-prime" ]

[ 862 ]

1

[ "GP" ]

[ "GenProp0289" ]

[ "GP:GenProp0289" ]

1

[ "6dqw", "6dqx" ]

2

[]

0

[ "IPR039718" ]

[]

1

0

1

[ "Bacteria", "Halobacteria", "Viruses", "ecological metagenomes" ]

[ 749, 49, 62, 2 ]

4

[]

0

true

Family

Ribonucleotide reductase alpha chain

RNR_alpha

5

IPR013351

13,351

Type III secretion system effector delivery regulator TyeA-related

T3SS_TyeA-rel

Domain

1,398

false

This entry represents a sequence region found in both small proteins of about 90 amino acids where it covers the whole sequence, and longer proteins of about 360 residues where it occurs in the C-terminal region. Some of the longer proteins (HrpJ) have N-terminal regions that contain . These proteins belong to bacteria...

[]

0

[ "NCBIFAM" ]

[ "TIGR02511" ]

[ "type_III_tyeA" ]

[ 1398 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "1xl3", "5c9e", "7yyg" ]

3

[ "PUB00021005" ]

[ "12614462" ]

[ "TyeA of Yersinia pseudotuberculosis is involved in regulation of Yop expression and is required for polarized translocation of Yop effectors." ]

[ 2003 ]

1

[]

[ "IPR015144" ]

0

1

0

[ "Bacteria", "metagenomes" ]

[ 1396, 2 ]

2

[]

0

true

Domain

Type III secretion system effector delivery regulator TyeA-related

T3SS_TyeA-rel

4