LiteFold/InterPro · Datasets at Hugging Face

IPR014956

14,956

Putative ParB-like nuclease

ParBc_2

Family

1,754

false

These proteins are probably distantly related to . Suggesting these, uncharacterised proteins have a nuclease function.

[]

0

[ "PFAM", "CDD" ]

[ "PF08857", "cd16390" ]

[ "ParBc_2", "ParB_N_Srx_like" ]

[ 1754, 1739 ]

2

[]

0

[ "2hwj" ]

1

[]

0

[]

[ "IPR016932" ]

0

1

0

[ "Bacteria", "Eukaryota", "Halorubrum sodomense", "metagenomes" ]

[ 1672, 68, 1, 13 ]

4

[]

0

true

Family

Putative ParB-like nuclease

ParBc_2

9

IPR014957

14,957

IDEAL domain

IDEAL_dom

Domain

4,102

false

This short domain is found at the C terminus of proteins in the UPF0302 family. The domain is named after the sequence of the most conserved region in some members. The function of this domain is unknown.

[]

0

[ "PFAM", "SMART" ]

[ "PF08858", "SM00914" ]

[ "IDEAL", "IDEAL" ]

[ 4069, 3602 ]

2

[]

0

[ "3do9" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Rhizophagus irregularis", "human gut metagenome" ]

[ 4091, 8, 1, 2 ]

4

[]

0

true

Domain

IDEAL domain

IDEAL_dom

1

IPR014958

14,958

DGC

Family

1,559

false

This protein appears to be a zinc binding domain from the conservation of four potential chelating cysteines. The protein is named after a conserved central motif, the function is unknown. The anaerobic and virulence modulator AnvM is found in a wide range of bacteria and contains a DGC conservative sequence. AnvM func...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08859", "PIRSF037181" ]

[ "DGC", "DGC" ]

[ 1559, 983 ]

2

[]

0

[]

0

[ "PUB00093679" ]

[ "31337721" ]

[ "Pseudomonas aeruginosa Regulatory Protein AnvM Controls Pathogenicity in Anaerobic Environments and Impacts Host Defense." ]

[ 2019 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Thelohanellus kitauei", "unclassified sequences" ]

[ 333, 1186, 1, 39 ]

4

[]

0

true

Family

DGC

6

IPR014960

14,960

Domain of unknown function DUF1828

DUF1828

Domain

1,068

false

This domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08861" ]

[ "DUF1828" ]

[ 1068 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanobacteriota", "Opisthokonta", "metagenomes" ]

[ 1003, 9, 36, 2, 18 ]

5

[]

0

true

Domain

Domain of unknown function DUF1828

DUF1828

6

IPR014961

14,961

Domain of unknown function DUF1829

DUF1829

Domain

539

false

This short protein is usually associated with .

[]

0

[ "PFAM" ]

[ "PF08862" ]

[ "DUF1829" ]

[ 539 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanobacteriota", "Rhizophagus irregularis", "metagenomes" ]

[ 512, 4, 14, 1, 8 ]

5

[]

0

true

Domain

Domain of unknown function DUF1829

DUF1829

4

IPR014963

14,963

Peptidoglycan synthesis regulatory protein ReoY-like, N-terminal domain

ReoY-like_N

Domain

1,684

false

This entry represents the N-terminal domain of Peptidoglycan synthesis regulatory protein ReoY ( ) which is involved in the PASTA kinase-mediated signalling pathway regulating peptidoglycan synthesis to maintain cell wall integrity [ ]. It modulates peptidoglycan (PG) synthesis pathway committed-step enzyme MurA [ ]. R...

[]

0

[ "PFAM" ]

[ "PF08864" ]

[ "UPF0302" ]

[ 1684 ]

1

[]

0

[ "3do9" ]

1

[ "PUB00104135" ]

[ "32469310" ]

[ "PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM." ]

[ 2020 ]

1

[]

0

null

[ "Bacillota", "Bacillus phage G", "metagenomes" ]

[ 1680, 2, 2 ]

3

[]

0

true

Domain

Peptidoglycan synthesis regulatory protein ReoY-like, N-terminal domain

ReoY-like_N

7

IPR014964

14,964

Protein of unknown function DUF1830

DUF1830

Family

615

false

This entry includes Uncharacterized protein sll0944 from Synechocystis sp. and other uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08865" ]

[ "DUF1830" ]

[ 615 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 615 ]

1

[]

0

true

Family

Protein of unknown function DUF1830

DUF1830

1

IPR014965

14,965

Putative amino acid metabolism

Amino_acid_metab_prot_put

Family

1,269

false

Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The pot...

[]

0

[ "PFAM" ]

[ "PF08866" ]

[ "DUF1831" ]

[ 1269 ]

1

[]

0

[ "2iay" ]

1

[ "PUB00055862" ]

[ "20944212" ]

[ "Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1268, 1 ]

2

[]

0

true

Family

Putative amino acid metabolism

Amino_acid_metab_prot_put

9

IPR014967

14,967

Uncharacterised protein family, YugN-like

Uncharacterised_YugN-like

Family

2,561

false

This entry contains proteins related to Bacillus subtilis YugN, they are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08868" ]

[ "YugN" ]

[ 2561 ]

1

[]

0

[ "2pww", "2r5x" ]

2

[]

0

[]

0

null

[ "Bacteria" ]

[ 2561 ]

1

[]

0

true

Family

Uncharacterised protein family, YugN-like

Uncharacterised_YugN-like

3

IPR014969

14,969

DNA sulphur modification protein DndE

DNA_S_DndE

Family

1,217

false

This entry describes the DndE protein encoded by an operon associated with a sulphur-containing modification to DNA (phosphorothioation)[ ]. The operon is sporadically distributed in bacteria, much like some restriction enzyme operons. DndE is part of a protein complex that also includes IscS, DndC, and DndE, involved ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF08870", "TIGR03184" ]

[ "DndE", "DNA_S_dndE" ]

[ 1217, 829 ]

2

[ "GP" ]

[ "GenProp0701" ]

[ "GP:GenProp0701" ]

1

[ "4lrv", "5wtu", "7x4e" ]

3

[ "PUB00042946", "PUB00088239", "PUB00088240", "PUB00088241" ]

[ "16102010", "22525332", "25269084", "26539172" ]

[ "A novel DNA modification by sulphur.", "Structural insights into DndE from Escherichia coli B7A involved in DNA phosphorothioation modification.", "In vivo mutational characterization of DndE involved in DNA phosphorothioate modification.", "Interactions of Dnd proteins involved in bacterial DNA phosphorothi...

[ 2005, 2012, 2014, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "metagenomes" ]

[ 27, 1169, 1, 20 ]

4

[]

0

true

Family

DNA sulphur modification protein DndE

DNA_S_DndE

3

IPR014971

14,971

KGK

Family

444

false

This protein is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.

[]

0

[ "PFAM" ]

[ "PF08872" ]

[ "KGK" ]

[ 444 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae" ]

[ 444 ]

1

[]

0

true

Family

KGK

4

IPR014972

14,972

Bacteriophage Mu, Gp37

Phage_Mu_Gp37

Family

687

false

This entry is represented by Bacteriophage Mu, Gp37 (also known as Probable tail terminator protein) which may stop tail tube polymerisation by capping the rapidly polymerising tail tube once it has reached its requisite length and prevents its depolymerisation [ ]. This family also has prophages matches, such as the G...

[]

0

[ "PFAM" ]

[ "PF08873" ]

[ "Phage_Mu_Gp37" ]

[ 687 ]

1

[]

0

[ "9khy", "9lj8" ]

2

[ "PUB00052083" ]

[ "19426744" ]

[ "The X-ray crystal structure of the phage lambda tail terminator protein reveals the biologically relevant hexameric ring structure and demonstrates a conserved mechanism of tail termination among diverse long-tailed phages." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Glossina brevipalpis", "metagenomes" ]

[ 667, 9, 1, 10 ]

4

[]

0

true

Family

Bacteriophage Mu, Gp37

Phage_Mu_Gp37

9

IPR014973

14,973

Domain of unknown function DUF1835

DUF1835

Domain

3,244

false

This is a presumed domain found in functionally uncharacterised proteins from bacteria. It is found associated with at the C-terminal.

[]

0

[ "PFAM" ]

[ "PF08874" ]

[ "DUF1835" ]

[ 3244 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Methanomicrobiaceae", "Opisthokonta", "Siphoviridae sp. ctF2K4", "metagenomes" ]

[ 3221, 4, 3, 1, 15 ]

5

[]

0

true

Domain

Domain of unknown function DUF1835

DUF1835

1

IPR014974

14,974

Protein of unknown function DUF1833

DUF1833

Family

1,014

false

This family of proteins are functionally uncharacterised and are predicted to adopt an all-β fold [ ]. They are often found in gene neighbourhoods containing genes for an NlpC peptidase and a Ubiquitin domain predicted to be involved in tail assembly [ ].

[]

0

[ "PFAM" ]

[ "PF08875" ]

[ "DUF1833" ]

[ 1014 ]

1

[]

0

[]

0

[ "PUB00034476" ]

[ "16859499" ]

[ "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 841, 9, 151, 13 ]

4

[]

0

true

Family

Protein of unknown function DUF1833

DUF1833

7

IPR014975

14,975

Protein of unknown function DUF1836

DUF1836

Family

3,804

false

This protein family appears to be primarily involved in transcriptional regulation and cellular processes. Members of this family, such as the one represented by (gene gbs1388), exhibit high levels of transcriptional activity and may be regulated by factors like the rex gene, indicating a role in significant cellular p...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08876", "PTHR40056" ]

[ "DUF1836", "" ]

[ 3800, 3761 ]

2

[]

0

[]

0

[ "PUB00156066", "PUB00156067", "PUB00156068" ]

[ "25855127", "34370789", "36704551" ]

[ "Critical roles of arginine in growth and biofilm development by Streptococcus gordonii.", "NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.", "<i>Clostridium beijerinckii</i> strain degeneration is driven by the loss of Spo0A activity." ]

[ 2015, 2021, 2022 ]

3

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3781, 23 ]

2

[]

0

true

Family

Protein of unknown function DUF1836

DUF1836

6

IPR014976

14,976

Anti-bacteriophage protein A/HamA, nuclease domain

AbpA_HamA_nuclease

Domain

1,962

false

Hachiman antiphage defence system has been described in Ralstonia solanacearum species complex (RSSC) and in Escherichia coli, and is composed of two genes, hamAB, which encode Anti-bacteriophage protein A (also known as HamA, represented in this entry), and an helicase (HamB/AbpB). These proteins confer temperature de...

[]

0

[ "PFAM" ]

[ "PF08878" ]

[ "HamA" ]

[ 1962 ]

1

[]

0

[ "8vx9", "8vxy", "8zue" ]

3

[ "PUB00094500", "PUB00097805", "PUB00097806", "PUB00101301", "PUB00162568", "PUB00162569" ]

[ "32544385", "32508782", "29371424", "25224971", "38464307", "40097437" ]

[ "CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection.", "Diversity and Evolutionary Dynamics of Antiphage Defense Systems in <i>Ralstonia solanacearum</i> Species Complex.", "Systematic discovery of antiphage defens...

[ 2020, 2020, 2018, 2014, 2024, 2025 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctcfw7", "unclassified sequences" ]

[ 28, 1909, 2, 1, 22 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Anti-bacteriophage protein A/HamA, nuclease domain

AbpA_HamA_nuclease

9

IPR014977

14,977

WRC domain

WRC_dom

Domain

10,638

false

The plant GROWTH-REGULATING FACTOR (GRF) proteins are putative transcription factors. They contain one or two WRC (Trp, Arg, Cys) domain(s). The WRC domain has two distinctive structural features, namely many basic amino acids (Arg and Lys) and the conserved spacing of three Cys and one His residues, the C3H motif. The...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08879", "PS51667" ]

[ "WRC", "WRC" ]

[ 10288, 10612 ]

2

[]

0

[]

0

[ "PUB00035453" ]

[ "12974814" ]

[ "The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis." ]

[ 2003 ]

1

[]

0

null

[ "Desulforamulus aquiferis", "Eukaryota" ]

[ 1, 10637 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 74, 43, 163 ]

3

true

Domain

WRC domain

WRC_dom

3

IPR014978

14,978

Glutamine-Leucine-Glutamine, QLQ

Gln-Leu-Gln_QLQ

Domain

13,787

false

The QLQ domain is characterised by the conserved Gln-Leu-Gln residues. Another feature of this domain is the absolute conservation of bulky aromatic/hydrophobic and acidic amino acid residues such as Phe, Trp, Tyr, Leu, Glu, or their equivalents in terms of chemical and radial properties. The Pro residue is also absolu...

[ "GO:0005524", "GO:0006355", "GO:0005634" ]

[ "ATP binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PROFILE", "SMART" ]

[ "PF08880", "PS51666", "SM00951" ]

[ "QLQ", "QLQ", "QLQ" ]

[ 12774, 13289, 13316 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1266695", "R-BTA-201722", "R-BTA-3214858", "R-BTA-3247509", "R-BTA-8939243", "R-BTA-9764725", "R-BTA-9933937", "R-BTA-9933939", "R-BTA-9933946", "R-BTA-9933947", "R-BTA-9934037", "R-CEL-8939243", "R-CEL-9764725", "R-CEL-9933939", "R-CEL-9934037", "R-DME-1266695", "R-DME-321485...

[ "REACTOME:R-BTA-1266695", "REACTOME:R-BTA-201722", "REACTOME:R-BTA-3214858", "REACTOME:R-BTA-3247509", "REACTOME:R-BTA-8939243", "REACTOME:R-BTA-9764725", "REACTOME:R-BTA-9933937", "REACTOME:R-BTA-9933939", "REACTOME:R-BTA-9933946", "REACTOME:R-BTA-9933947", "REACTOME:R-BTA-9934037", "REACTOME...

62

[ "6lth", "6ltj", "6uxv", "6uxw", "7c4j", "7vdt", "7vdv", "7vrb", "7vrc", "7y8r" ]

10

[ "PUB00035453" ]

[ "12974814" ]

[ "The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Larkinella terrae" ]

[ 13786, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 55, 1, 10, 3, 23, 16, 1, 22, 12, 1, 1, 105 ]

12

true

Domain

Glutamine-Leucine-Glutamine, QLQ

Gln-Leu-Gln_QLQ

3

IPR014981

14,981

Flagellin D3

Flagellin_D3

Domain

1,865

false

This domain is found in the central portion bacterial flagellin FliC, it contains a structural motif called a β-folium fold [ ]. Although no specific function is assigned its deletion leads to a reduction in filament stability [ ].

[]

0

[ "PFAM" ]

[ "PF08884" ]

[ "Flagellin_D3" ]

[ 1865 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-433822", "R-GGA-451534", "R-GGA-977240", "R-HSA-168176", "R-HSA-5602680", "R-HSA-5603037", "R-HSA-844623", "R-HSA-975871" ]

[ "REACTOME:R-GGA-433822", "REACTOME:R-GGA-451534", "REACTOME:R-GGA-977240", "REACTOME:R-HSA-168176", "REACTOME:R-HSA-5602680", "REACTOME:R-HSA-5603037", "REACTOME:R-HSA-844623", "REACTOME:R-HSA-975871" ]

8

[ "1io1", "1ucu", "3a5x", "6jy0", "6rgv", "8cxm", "8fml", "9gnz", "9go6", "9m6h" ]

10

[ "PUB00026074", "PUB00035400" ]

[ "11268201", "7860589" ]

[ "Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling.", "Flagellar filament structure and cell motility of Salmonella typhimurium mutants lacking part of the outer domain of flagellin." ]

[ 2001, 1995 ]

2

[]

0

null

[ "Bacteria" ]

[ 1865 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellin D3

Flagellin_D3

5

IPR014982

14,982

GSCFA

Domain

3,516

false

This group of proteins are functionally uncharacterised. They have been named GSCFA after a highly conserved N-terminal motif in the alignment, they are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08885" ]

[ "GSCFA" ]

[ 3516 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3432, 25, 59 ]

3

[]

0

true

Domain

GSCFA

4

IPR014983

14,983

GAD-related

GAD-rel

Domain

1,796

false

This entry represents the N-terminal domain of the type VI secretion system (T6SS) immunity protein Tdi1 from Agrobacterium tumefaciens (Atu4351, ) and other bacterial proteins. This domain, which appears to be distantly related to the GAD domain , folds into a a seven-stranded twisted antiparallel β-sheet, a two-stran...

[]

0

[ "PFAM" ]

[ "PF08887" ]

[ "GAD-like" ]

[ 1796 ]

1

[]

0

[ "6itw", "8fzz", "8g0k" ]

3

[ "PUB00100858" ]

[ "30839288" ]

[ "Crystal structure of the type VI immunity protein Tdi1 (Atu4351) from Agrobacterium tumefaciens." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Microviridae sp. ctoGr7", "Opisthokonta", "metagenomes" ]

[ 1769, 1, 4, 22 ]

4

[]

0

true

Domain

GAD-related

GAD-rel

7

IPR014984

14,984

HopJ type III effector protein

HopJ

Family

2,914

false

Pathovars of Pseudomonas syringae interact with their plant hosts via the action of Hrp outer protein (Hop) effector proteins, injected into plant cells by the type III secretion system. The proteins are called HopJ after the original member HopPmaJ [ ].

[]

0

[ "PFAM" ]

[ "PF08888" ]

[ "HopJ" ]

[ 2914 ]

1

[]

0

[ "2qhq", "2qm2" ]

2

[ "PUB00035409" ]

[ "15828679" ]

[ "Proposed guidelines for a unified nomenclature and phylogenetic analysis of type III Hop effector proteins in the plant pathogen Pseudomonas syringae." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2798, 74, 42 ]

3

[]

0

true

Family

HopJ type III effector protein

HopJ

4

IPR014985

14,985

WbqC-like protein family

WbqC

Family

5,485

false

This family of proteins are functionally uncharacterised. However, it is found in an O-antigen gene cluster in Escherichia coli [ ] and other bacteria [ ] suggesting a role in O-antigen production. It has been suggested that wbnG may code for a glycine transferase [ ].

[]

0

[ "PFAM" ]

[ "PF08889" ]

[ "WbqC" ]

[ 5485 ]

1

[]

0

[]

0

[ "PUB00035484", "PUB00035485" ]

[ "12843098", "14687563" ]

[ "Sequence of the Escherichia coli O121 O-antigen gene cluster and detection of enterohemorrhagic E. coli O121 by PCR amplification of the wzx and wzy genes.", "Structure of the Shigella dysenteriae 7 O antigen gene cluster and identification of its antigen specific genes." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 61, 5276, 5, 2, 141 ]

5

[]

0

true

Family

WbqC-like protein family

WbqC

3

IPR014986

14,986

Phage-like element PBSX protein XkdN-like

XkdN-like

Family

1,449

false

This entry is represents Phage-like element PBSX protein XkdN from Bacillus subtilis (strain 168) and similar proteins predominantly found in Firmicutes and some tailed bacteriophages. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. Members of this group of pro...

[]

0

[ "PFAM" ]

[ "PF08890" ]

[ "Phage_TAC_5" ]

[ 1449 ]

1

[]

0

[ "3klu" ]

1

[ "PUB00048232", "PUB00075454", "PUB00075672" ]

[ "19251647", "23542344", "23542343" ]

[ "The phage lambda major tail protein structure reveals a common evolution for long-tailed phages and the type VI bacterial secretion system.", "A conserved spiral structure for highly diverged phage tail assembly chaperones.", "Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster."...

[ 2009, 2013, 2013 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolapillus millepedarum", "Viruses", "ecological metagenomes" ]

[ 1342, 3, 1, 91, 12 ]

5

[]

0

true

Family

Phage-like element PBSX protein XkdN-like

XkdN-like

3

IPR014988

14,988

Uncharacterised protein family, YqcI/YcgG

Uncharacterised_YqcI/YcgG

Family

3,092

false

This group of proteins are functionally uncharacterised. They include YqcI and YcgG from Bacillus subtilis. The alignment contains a conserved FPC motif at the N terminus and CPF at the C terminus.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08892", "PTHR40045" ]

[ "YqcI_YcgG", "" ]

[ 3092, 2941 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 259, 2537, 295, 1 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Uncharacterised protein family, YqcI/YcgG

Uncharacterised_YqcI/YcgG

3

IPR014989

14,989

Protein of unknown function DUF1839

DUF1839

Family

945

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08893" ]

[ "DUF1839" ]

[ 945 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 941, 4 ]

2

[]

0

true

Family

Protein of unknown function DUF1839

DUF1839

6

IPR014991

14,991

Protein of unknown function DUF1840

DUF1840

Family

1,844

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08895" ]

[ "DUF1840" ]

[ 1844 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Pentapetalae", "Pseudomonadati", "metagenomes" ]

[ 2, 1823, 19 ]

3

[]

0

true

Family

Protein of unknown function DUF1840

DUF1840

9

IPR014992

14,992

Domain of unknown function DUF1842

DUF1842

Domain

557

false

This domain is found at the N terminus of proteins that are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08896" ]

[ "DUF1842" ]

[ 557 ]

1

[]

0

[ "8t0b", "8t1m", "8t1n" ]

3

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 556, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF1842

DUF1842

9

IPR014993

14,993

Protein of unknown function DUF1841

DUF1841

Family

1,920

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08897" ]

[ "DUF1841" ]

[ 1920 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "miscellaneous Crenarchaeota group-1 archaeon SG8-32-3", "unclassified sequences" ]

[ 1855, 2, 1, 62 ]

4

[]

0

true

Family

Protein of unknown function DUF1841

DUF1841

2

IPR014994

14,994

Domain of unknown function DUF1843

DUF1843

Domain

479

false

This domain is found in functionally uncharacterised proteins. It can be found independently or at the C terminus of the protein.

[]

0

[ "PFAM" ]

[ "PF08898" ]

[ "DUF1843" ]

[ 479 ]

1

[ "GP" ]

[ "GenProp0920" ]

[ "GP:GenProp0920" ]

1

[ "8t0b", "8t1m", "8t1n" ]

3

[]

0

[]

0

null

[ "Bacteria" ]

[ 479 ]

1

[]

0

true

Domain

Domain of unknown function DUF1843

DUF1843

8

IPR014995

14,995

Protein of unknown function DUF1844

DUF1844

Family

3,454

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08899" ]

[ "DUF1844" ]

[ 3454 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes", "environmental samples" ]

[ 3341, 2, 108, 3 ]

4

[]

0

true

Family

Protein of unknown function DUF1844

DUF1844

2

IPR014997

14,997

Protein of unknown function DUF1847

DUF1847

Family

965

false

This entry represents Uncharacterized protein MJ0455 and related uncharacterised proteins from prokaryotes. They contain 4 N-terminal cysteines that may form a zinc-binding domain.

[]

0

[ "PFAM" ]

[ "PF08901" ]

[ "DUF1847" ]

[ 965 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 121, 800, 44 ]

3

[]

0

true

Family

Protein of unknown function DUF1847

DUF1847

1

IPR014998

14,998

Protein of unknown function DUF1848

DUF1848

Family

1,693

false

This group of proteins are functionally uncharacterised. The C terminus contains a cluster of cysteines that are similar to the iron-sulphur cluster found at the N terminus of .

[]

0

[ "PFAM" ]

[ "PF08902" ]

[ "DUF1848" ]

[ 1693 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Symbiodiniaceae", "Viruses", "unclassified sequences" ]

[ 61, 1560, 13, 9, 50 ]

5

[]

0

true

Family

Protein of unknown function DUF1848

DUF1848

1

IPR014999

14,999

Family of unknown function DUF1846

DUF1846

Family

1,632

false

This entry represents the uncharacterised protein family DUF1846 (also kwon as UPF0371). Some members of the family are annotated as ATP-dependent peptidases. This is a P-loop-like domain .

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_01567", "PIRSF033132" ]

[ "UPF0371", "DUF1846" ]

[ 1088, 1631 ]

2

[]

0

[ "3bh1", "7f00" ]

2

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1628, 4 ]

2

[]

0

true

Family

Family of unknown function DUF1846

DUF1846

5

IPR015000

15,000

EipB-like

Family

1,506

false

This entry includes a group of bacterial proteins, including EipB from Brucella. EipB is a periplasmic protein that functions as part of a system required for cell envelope homeostasis. It adopts a β-spiral fold, consisting of 14 β-strands and 2 α-helices [ ].

[]

0

[ "PFAM" ]

[ "PF08904" ]

[ "EipB_like" ]

[ 1506 ]

1

[]

0

[ "6ntr" ]

1

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Pseudomonadati", "Symbiodiniaceae", "metagenomes" ]

[ 1495, 3, 8 ]

3

[]

0

true

Family

EipB-like

7

IPR015001

15,001

Protein of unknown function DUF1850

DUF1850

Family

2,898

false

This entry contains proteins, which are functionally uncharacterised. Some members of this family appear to be miss-annotated as RocC an amino acid transporter from Bacillus subtilis.

[]

0

[ "PFAM" ]

[ "PF08905" ]

[ "DUF1850" ]

[ 2898 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014451" ]

0

1

0

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "unclassified sequences" ]

[ 247, 2615, 1, 35 ]

4

[]

0

true

Family

Protein of unknown function DUF1850

DUF1850

7

IPR015002

15,002

T6SS immunity protein Tdi1, C-terminal

T6SS_Tdi1_C

Domain

2,235

false

This entry represents a domain found at the C-terminal region of the type VI secretion system (T6SS) immunity protein Tdi1 from Agrobacterium tumefaciens (Atu4351, ) and similar bacterial proteins. Tdi1 is organised into a N-terminal GAD-related domain ( ) and a C-terminal domain likely to exist as an insertion in the ...

[]

0

[ "PFAM" ]

[ "PF08906" ]

[ "T6SS_Tdi1_C" ]

[ 2235 ]

1

[]

0

[ "6itw", "8fzz", "8g0k" ]

3

[ "PUB00100858" ]

[ "30839288" ]

[ "Crystal structure of the type VI immunity protein Tdi1 (Atu4351) from Agrobacterium tumefaciens." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Microviridae sp. ctoGr7", "Opisthokonta", "metagenomes" ]

[ 2208, 1, 4, 22 ]

4

[]

0

true

Domain

T6SS immunity protein Tdi1, C-terminal

T6SS_Tdi1_C

6

IPR015003

15,003

Protein of unknown function DUF1853

DUF1853

Family

3,520

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08907" ]

[ "DUF1853" ]

[ 3520 ]

1

[]

0

[]

0

[ "PUB00092848" ]

[ "30936371" ]

[ "Brucella periplasmic protein EipB is a molecular determinant of cell envelope integrity and virulence." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3343, 164, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF1853

DUF1853

9

IPR015004

15,004

MesX

Family

2,528

false

This family represents the putative oxygenase component of the oxygen-dependent methionine synthase MesD, called MesX, present in aerobic bacteria [ ]. MesX is required for MesD for its activity. MesD/MesX has the advantage of not requiring cobalamin for methionine synthesis.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08908", "PIRSF034367" ]

[ "MesX", "DUF1852" ]

[ 2528, 2195 ]

2

[]

0

[]

0

[ "PUB00097274" ]

[ "33534785" ]

[ "Four families of folate-independent methionine synthases." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2509, 8, 11 ]

3

[]

0

true

Family

MesX

8

IPR015005

15,005

Domain of unknown function DUF1854

DUF1854

Domain

1,108

false

These protein is functionally uncharacterised. It is found at the C terminus of a number of ATP transporter proteins suggesting it may be involved in ligand binding.

[]

0

[ "PFAM" ]

[ "PF08909" ]

[ "DUF1854" ]

[ 1108 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "metagenomes" ]

[ 43, 1042, 1, 22 ]

4

[]

0

true

Domain

Domain of unknown function DUF1854

DUF1854

2

IPR015007

15,007

Nuclear pore complex, NUP2/50/61

NUP2/50/61

Domain

3,293

false

This entry represents a domain found in Nup2, 50 and 61, which are components of the nuclear pore complex. NUP2 encodes a non-essential nuclear pore protein that has a central domain similar to those of Nsp1 and Nup1[ , ]. Transport of macromolecules between the nucleus and the cytoplasm of eukaryotic cells occurs thro...

[ "GO:0005643" ]

[ "nuclear pore" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF08911" ]

[ "NUP50" ]

[ 3293 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

84

[ "1un0", "2c1m", "2c1t", "3tj3" ]

4

[ "PUB00019946", "PUB00035440", "PUB00053733", "PUB00053734", "PUB00053735", "PUB00053736", "PUB00053737", "PUB00053738", "PUB00053739", "PUB00053740", "PUB00053741", "PUB00053742", "PUB00053743", "PUB00053744", "PUB00053745", "PUB00053746" ]

[ "9442897", "16222336", "8443417", "9640541", "9630243", "8311839", "8740526", "7574503", "7537513", "8227139", "9659919", "8045927", "7638224", "9159086", "7638906", "7688974" ]

[ "Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking.", "Nup50/Npap60 function in nuclear protein import complex disassembly and importin recycling.", "NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.", "Transport routes ...

[ 1997, 2005, 1993, 1998, 1998, 1994, 1996, 1995, 1994, 1993, 1998, 1994, 1995, 1997, 1995, 1993 ]

16

[]

0

null

[ "Eukaryota", "Thalassomonas viridans" ]

[ 3292, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 2, 1, 5, 2, 2, 8, 1, 1, 9 ]

10

true

Domain

Nuclear pore complex, NUP2/50/61

NUP2/50/61

7

IPR015008

15,008

ROCK, Rho binding domain

ROCK_Rho-bd_dom

Domain

4,484

false

The Rho-ROCK pathway modulates the phosphorylation level of a variety of important signalling proteins and is thereby involved in miscellaneous cellular processes including cell migration, neurite outgrowth, and smooth muscle contraction. The enzyme activity of the two ROCK isoforms, ROCKI/ ROKbeta/p160(ROCK) and ROCKI...

[ "GO:0031267" ]

[ "small GTPase binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF08912", "PS51859" ]

[ "Rho_Binding", "RHO_BD" ]

[ 4417, 4261 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.11.39", "R-CEL-111465", "R-CEL-3928662", "R-CEL-416482", "R-CEL-416572", "R-CEL-4420097", "R-CEL-5627117", "R-CEL-6798695", "R-CEL-8980692", "R-CEL-9013026", "R-CEL-9013407", "R-HSA-111465", "R-HSA-3928662", "R-HSA-3928663", "R-HSA-416482", "R-HSA-416572", "R-HSA-4420097", "R-...

[ "EC:2.7.11.39", "REACTOME:R-CEL-111465", "REACTOME:R-CEL-3928662", "REACTOME:R-CEL-416482", "REACTOME:R-CEL-416572", "REACTOME:R-CEL-4420097", "REACTOME:R-CEL-5627117", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8980692", "REACTOME:R-CEL-9013026", "REACTOME:R-CEL-9013407", "REACTOME:R-HSA-11146...

61

[ "1s1c", "1uix" ]

2

[ "PUB00022662", "PUB00031791" ]

[ "14660612", "12954645" ]

[ "Structural insights into the interaction of ROCKI with the switch regions of RhoA.", "Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase." ]

[ 2004, 2003 ]

2

[]

0

null

[ "Eukaryota", "Paenibacillus lautus" ]

[ 4482, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 36, 6, 10, 8, 10 ]

6

true

Domain

ROCK, Rho binding domain

ROCK_Rho-bd_dom

2

IPR015009

15,009

Vinculin-binding site-containing domain

Vinculin-bd_dom

Domain

5,135

false

Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions [ ]. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a se...

[]

0

[ "PFAM" ]

[ "PF08913" ]

[ "VBS" ]

[ 5135 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-114608", "R-HSA-354192", "R-HSA-354194", "R-HSA-372708", "R-HSA-381038", "R-HSA-399955", "R-HSA-445355", "R-HSA-5674135", "R-HSA-6802946", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-6802955", "R-HSA-9649948", "R-HSA-9656223", "R-HSA-9856530", "R-MMU-114608", "R-MMU-354192", "R...

[ "REACTOME:R-HSA-114608", "REACTOME:R-HSA-354192", "REACTOME:R-HSA-354194", "REACTOME:R-HSA-372708", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-399955", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-5674135", "REACTOME:R-HSA-6802946", "REACTOME:R-HSA-6802948", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA...

22

[ "1rkc", "1xwj", "2b0h", "2kvp", "6r9t", "8vdo", "8vdp", "8vdq", "8vdr" ]

9

[ "PUB00035479", "PUB00075415" ]

[ "16460027", "20399778" ]

[ "Structural and dynamic characterization of a vinculin binding site in the talin rod.", "The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site." ]

[ 2006, 2010 ]

2

[]

0

null

[ "Methylomonas aurea", "Opisthokonta" ]

[ 1, 5134 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 17, 6, 7, 14, 15 ]

6

true

Domain

Vinculin-binding site-containing domain

Vinculin-bd_dom

8

IPR015010

15,010

TERF2-interacting telomeric protein 1, Myb domain

TERF2IP_Myb

Domain

2,869

false

TERF2-interacting telomeric protein 1 (TERF2IP) is the homologous of Rap1 from yeast (not included in this entry). These proteins are involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE) [ , ]. TERF2IP is required for repression of homology-directed repair ...

[]

0

[ "PFAM" ]

[ "PF08914" ]

[ "Myb_Rap1" ]

[ 2869 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-110330", "R-BTA-110331", "R-BTA-171306", "R-BTA-171319", "R-BTA-174411", "R-BTA-174414", "R-BTA-174417", "R-BTA-174430", "R-BTA-174437", "R-BTA-2559586", "R-BTA-9670095", "R-GGA-418124", "R-HSA-110328", "R-HSA-110329", "R-HSA-110330", "R-HSA-110331", "R-HSA-1221632", "R-HSA-...

[ "REACTOME:R-BTA-110330", "REACTOME:R-BTA-110331", "REACTOME:R-BTA-171306", "REACTOME:R-BTA-171319", "REACTOME:R-BTA-174411", "REACTOME:R-BTA-174414", "REACTOME:R-BTA-174417", "REACTOME:R-BTA-174430", "REACTOME:R-BTA-174437", "REACTOME:R-BTA-2559586", "REACTOME:R-BTA-9670095", "REACTOME:R-GGA-4...

52

[ "1fex", "8rd4" ]

2

[ "PUB00021585", "PUB00066683", "PUB00128653", "PUB00154828" ]

[ "11545594", "16166375", "8194531", "19763083" ]

[ "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains.", "Shelterin: the protein complex that shapes and safeguards human telomeres.", "The yeast telomere-binding protein RAP1 binds to and promotes the formation of DNA...

[ 2001, 2005, 1994, 2009 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2869 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 11, 3, 2, 1, 3, 1 ]

6

true

Domain

TERF2-interacting telomeric protein 1, Myb domain

TERF2IP_Myb

3

IPR015011

15,011

Threonyl-tRNA synthetase, editing domain, archaea

Threonyl-tRNA_syn_edit_dom_arc

Domain

778

false

Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA...

[ "GO:0004829", "GO:0005524", "GO:0008270", "GO:0005737" ]

[ "threonine-tRNA ligase activity", "ATP binding", "zinc ion binding", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "cellular_component" ]

4

[ "PFAM" ]

[ "PF08915" ]

[ "tRNA-Thr_ED" ]

[ 778 ]

1

[ "EC" ]

[ "6.1.1.3" ]

[ "EC:6.1.1.3" ]

1

[ "1y2q", "2hkz", "2hl0", "2hl1", "2hl2", "3pd2", "3pd3", "3pd4", "3pd5", "4rr6", "4rr7", "4rr8", "4rr9", "4rra", "4rrb", "4rrc", "4rrd", "4rrf", "4rrg", "4rrh", "4rri", "4rrj", "4rrk", "4rrl", "4rrm", "4rrq", "4rrr", "4s02", "4s03", "4s0i", "4s0j", "4s0k"...

33

[ "PUB00035475" ]

[ "15908961" ]

[ "A D-amino acid editing module coupled to the translational apparatus in archaea." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 611, 122, 45 ]

3

[]

0

true

Domain

Threonyl-tRNA synthetase, editing domain, archaea

Threonyl-tRNA_syn_edit_dom_arc

1

IPR015012

15,012

Phenylalanine zipper

Phe_ZIP

Domain

3,070

false

The phenylalanine zipper consists of aromatic side chains from ten phenylalanine residues that are stacked within a hydrophobic core. This zipper mediates dimerisation of various proteins, such as APS, SH2-B and Lnk [ ].

[]

0

[ "PFAM" ]

[ "PF08916" ]

[ "Phe_ZIP" ]

[ 3070 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1170546", "R-HSA-1433559", "R-HSA-2586552", "R-HSA-9706369", "R-HSA-982772", "R-HSA-983231", "R-MMU-1170546", "R-MMU-1433559", "R-MMU-9706369", "R-MMU-982772", "R-MMU-983231", "R-RNO-1170546", "R-RNO-1433559", "R-RNO-982772", "R-RNO-983231" ]

[ "REACTOME:R-HSA-1170546", "REACTOME:R-HSA-1433559", "REACTOME:R-HSA-2586552", "REACTOME:R-HSA-9706369", "REACTOME:R-HSA-982772", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-1170546", "REACTOME:R-MMU-1433559", "REACTOME:R-MMU-9706369", "REACTOME:R-MMU-982772", "REACTOME:R-MMU-983231", "REACTOME:R-...

15

[ "1q2h" ]

1

[ "PUB00030088" ]

[ "15378031" ]

[ "A phenylalanine zipper mediates APS dimerization." ]

[ 2004 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 3070 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 7, 10, 18 ]

5

true

Domain

Phenylalanine zipper

Phe_ZIP

3

IPR015013

15,013

Transforming growth factor beta receptor 2 ectodomain

Transforming_GF_b_rcpt_2_ecto

Domain

2,033

false

The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine β-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel β-sheet, eight-residues long at its centre, covered by a second lay...

[ "GO:0005026", "GO:0005524", "GO:0046872", "GO:0006468", "GO:0016020" ]

[ "transforming growth factor beta receptor activity, type II", "ATP binding", "metal ion binding", "protein phosphorylation", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PFAM", "CDD" ]

[ "PF08917", "cd23538" ]

[ "ecTbetaR2", "TFP_LU_ECD_TGFR2" ]

[ 2033, 1912 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.30", "R-GGA-2173788", "R-GGA-2173789", "R-GGA-2173791", "R-GGA-9839389", "R-HSA-2173788", "R-HSA-2173789", "R-HSA-2173791", "R-HSA-3304356", "R-HSA-3642279", "R-HSA-3645790", "R-HSA-3656532", "R-HSA-3656535", "R-HSA-5689603", "R-HSA-9839389", "R-MMU-2173788", "R-MMU-2173789",...

[ "EC:2.7.11.30", "REACTOME:R-GGA-2173788", "REACTOME:R-GGA-2173789", "REACTOME:R-GGA-2173791", "REACTOME:R-GGA-9839389", "REACTOME:R-HSA-2173788", "REACTOME:R-HSA-2173789", "REACTOME:R-HSA-2173791", "REACTOME:R-HSA-3304356", "REACTOME:R-HSA-3642279", "REACTOME:R-HSA-3645790", "REACTOME:R-HSA-36...

23

[ "1ks6", "1ktz", "1m9z", "1plo", "2pjy", "3kfd", "4p7u", "4xjj", "5tx4", "5ty4", "8g4k", "9b9f", "9e9g", "9fdy", "9fk5", "9fkp" ]

16

[ "PUB00022449", "PUB00026815", "PUB00027273", "PUB00042868", "PUB00061298", "PUB00066094", "PUB00131065", "PUB00144010", "PUB00147296", "PUB00157949", "PUB00157965", "PUB00157968", "PUB00157973", "PUB00157978", "PUB00157979", "PUB00157980", "PUB00157981", "PUB00157982", "PUB001579...

[ "12939140", "11850637", "12121646", "9865696", "21441952", "18243111", "19533785", "12202987", "16982625", "8555189", "12941698", "9472030", "7774578", "20207738", "16251899", "20358619", "21949523", "15235604", "11212236", "10789724", "9590282", "11483955", "8973329", ...

[ "Solution structure and backbone dynamics of the TGFbeta type II receptor extracellular domain.", "Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.", "The 1.1 A crystal structure of human TGF-beta type II receptor ligand binding domain.", "SARA, a FYVE domain protein that recruits Smad2 t...

[ 2003, 2002, 2002, 1998, 2011, 2008, 2009, 2002, 2006, 1996, 2003, 1998, 1995, 2010, 2006, 2010, 2011, 2004, 2001, 2000, 1998, 2001, 1996, 1996, 1996, 1994, 1992, 1992 ]

28

[]

0

null

[ "Chordata" ]

[ 2033 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 32, 14, 6, 4 ]

4

true

Domain

Transforming growth factor beta receptor 2 ectodomain

Transforming_GF_b_rcpt_2_ecto

8

IPR015014

15,014

PhoQ Sensor domain

PhoQ_Sensor

Domain

1,420

false

The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, wh...

[ "GO:0004673", "GO:0005524", "GO:0046872", "GO:0000160", "GO:0018106", "GO:0016020" ]

[ "protein histidine kinase activity", "ATP binding", "metal ion binding", "phosphorelay signal transduction system", "peptidyl-histidine phosphorylation", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

6

[ "PFAM" ]

[ "PF08918" ]

[ "PhoQ_Sensor" ]

[ 1420 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.7.13.3", "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531...

[ "EC:2.7.13.3", "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720",...

37

[ "1yax", "3bq8", "3bqa", "4uey", "6a8u", "6a8v" ]

6

[ "PUB00035449", "PUB00099685" ]

[ "16406409", "34424339" ]

[ "Metal bridges between the PhoQ sensor domain and the membrane regulate transmembrane signaling.", "A catalogue of signal molecules that interact with sensor kinases, chemoreceptors and transcriptional regulators." ]

[ 2006, 2021 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 1414, 5, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

PhoQ Sensor domain

PhoQ_Sensor

9

IPR015015

15,015

F-actin binding

F-actin-binding

Domain

3,729

false

The F-actin binding domain forms a compact bundle of four antiparallel α-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [ ]. Protei...

[ "GO:0004715", "GO:0005524", "GO:0006468" ]

[ "non-membrane spanning protein tyrosine kinase activity", "ATP binding", "protein phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF08919", "SM00808" ]

[ "F_actin_bind", "FABD" ]

[ 3727, 3609 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.2", "R-CEL-2029482", "R-CEL-5663213", "R-CEL-8939236", "R-CEL-9013149", "R-CEL-9013423", "R-CEL-9841922", "R-CEL-9860927", "R-DME-2029482", "R-DME-428890", "R-DME-525793", "R-DME-5663213", "R-DME-5693565", "R-DME-69231", "R-DME-9013149", "R-DME-9013423", "R-DME-9841922", "R...

[ "EC:2.7.10.2", "REACTOME:R-CEL-2029482", "REACTOME:R-CEL-5663213", "REACTOME:R-CEL-8939236", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013423", "REACTOME:R-CEL-9841922", "REACTOME:R-CEL-9860927", "REACTOME:R-DME-2029482", "REACTOME:R-DME-428890", "REACTOME:R-DME-525793", "REACTOME:R-DME-56632...

47

[ "1zzp", "2kk1" ]

2

[ "PUB00035395", "PUB00066794", "PUB00066795" ]

[ "16109371", "9037071", "11971963" ]

[ "Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl.", "Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.", "c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage." ]

[ 2005, 1997, 2002 ]

3

[]

0

null

[ "Abelson murine leukemia virus", "Eikenella", "Eukaryota" ]

[ 1, 2, 3726 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 7, 10, 13, 6, 12 ]

6

true

Domain

F-actin binding

F-actin-binding

8

IPR015016

15,016

Splicing factor 3B subunit 1

SF3b_su1

Domain

4,783

false

This group of proteins consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C terminus β-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) β-sheet, which is in turn connected to an α-helix by a loop that makes extensive contacts with both the sh...

[]

0

[ "PFAM" ]

[ "PF08920" ]

[ "SF3b1" ]

[ 4783 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5250924", "R-HSA-72163", "R-HSA-72165", "R-MMU-5250924", "R-MMU-72163", "R-MMU-72165" ]

[ "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165" ]

6

[ "2f9d", "2f9j", "2fho", "3lqv", "5ife", "5o9z", "5z56", "5z57", "5z58", "5zya", "6ah0", "6ahd", "6ff4", "6ff7", "6qx9", "6y50", "6y53", "6y5q", "7abg", "7abh", "7abi", "7dvq", "7evo", "7onb", "7q3l", "7q4o", "7q4p", "7qtt", "7vpx", "8ch6", "8h6e", "8h6j"...

50

[ "PUB00035461" ]

[ "16432215" ]

[ "Crystal structure of a core spliceosomal protein interface." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4783 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 3, 2, 5, 5, 1, 7, 3, 1, 12 ]

11

true

Domain

Splicing factor 3B subunit 1

SF3b_su1

4

IPR015017

15,017

Protein of unknown function DUF1904

DUF1904

Family

1,165

false

This entry represents a family of hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08921" ]

[ "DUF1904" ]

[ 1165 ]

1

[]

0

[ "1u9d", "4m1a" ]

2

[]

0

[]

0

null

[ "Arabidopsis thaliana", "Bacteria", "metagenomes" ]

[ 1, 1156, 8 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1904

DUF1904

1

IPR015018

15,018

Protein of unknown function DUF1905

DUF1905

Family

7,451

false

This family consist of hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08922" ]

[ "DUF1905" ]

[ 7451 ]

1

[]

0

[ "2d9r" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 7373, 5, 7, 66 ]

4

[]

0

true

Family

Protein of unknown function DUF1905

DUF1905

4

IPR015019

15,019

Ragulator complex protein LAMTOR3

LAMTOR3

Family

2,018

false

Ragulator complex protein LAMTOR3 (for lysosomal adaptor and MAPK and MTOR activator 3) is a regulator of the TOR pathway, which is a signalling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids [ ].

[ "GO:0032006" ]

[ "regulation of TOR signaling" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER", "SMART" ]

[ "PF08923", "PTHR13378", "SM01278" ]

[ "MAPKK1_Int", "", "MAPKK1_Int" ]

[ 1988, 1838, 1910 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2031", "R-BTA-1632852", "R-BTA-165159", "R-BTA-166208", "R-BTA-380972", "R-BTA-5628897", "R-BTA-5674135", "R-BTA-6798695", "R-BTA-8943724", "R-BTA-9639288", "R-DDI-1632852", "R-DDI-165159", "R-DDI-166208", "R-DDI-380972", "R-DDI-5628897", "R-DDI-5674135", "R-DDI-6798695", "...

[ "GP:GenProp2031", "REACTOME:R-BTA-1632852", "REACTOME:R-BTA-165159", "REACTOME:R-BTA-166208", "REACTOME:R-BTA-380972", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-5674135", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8943724", "REACTOME:R-BTA-9639288", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-165...

70

[ "1sko", "1vet", "1veu", "2zl1", "3cpt", "5x6u", "5x6v", "5y39", "5y3a", "5yk3", "6b9x", "6ehp", "6ehr", "6nzd", "6u62", "6ulg", "6wj2", "6wj3", "7t3a", "7t3b", "7t3c", "7ux2", "7uxc", "7uxh", "8dhb", "9ed4", "9ed6" ]

27

[ "PUB00059150" ]

[ "19539012" ]

[ "The TOR pathway comes of age." ]

[ 2009 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 9, 9, 2000 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 2, 2, 4, 2 ]

6

true

Family

Ragulator complex protein LAMTOR3

LAMTOR3

9

IPR015020

15,020

Rv2525c-like, glycoside hydrolase-like domain

Rv2525c-like_Glyco_Hydro-like

Domain

4,958

false

This domain is found in uncharacterised bacterial proteins, including the putative peptidoglycan hydrolase Rv2525c from Mycobacterium tuberculosis [ , ]. Rv2525c may function as a peptidoglycan hydrolase with glycosidase activity as this domain has a typical TIM barrel-like fold characteristic of glycoside hydrolases [...

[]

0

[ "PFAM" ]

[ "PF08924" ]

[ "Rv2525c_GlyHyd-like" ]

[ 4958 ]

1

[]

0

[ "1sfs", "4pmn", "4pmo", "4pmq", "4pmr" ]

5

[ "PUB00100886", "PUB00100887" ]

[ "25869294", "25260828" ]

[ "Expression, Purification and Characterisation of Secreted Esterase Rv2525c from Mycobacterium tuberculosis.", "Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c." ]

[ 2015, 2014 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 4906, 36, 8, 8 ]

4

[]

0

true

Domain

Rv2525c-like, glycoside hydrolase-like domain

Rv2525c-like_Glyco_Hydro-like

6

IPR015021

15,021

Ester hydrolase C11orf54, Domain of unknown function DUF1907

C11orf54_DUF1907

Domain

2,570

false

This entry represents a domain found in Ester hydrolase C11orf54 (also known as PTD012) and similar proteins predominantly found in animals and fungi. The structure of this domain displays an α-β-β-α four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "SMART", "CDD" ]

[ "PF08925", "PTHR13204", "SM01168", "cd17298" ]

[ "DUF1907", "", "DUF1907", "DUF1907" ]

[ 2554, 2463, 2489, 2055 ]

4

[ "EC", "METACYC" ]

[ "4.1.1.34", "PWY-5525" ]

[ "EC:4.1.1.34", "METACYC:PWY-5525" ]

2

[ "1xcr", "3w6q", "3w6w", "6ju4", "6ju5", "6jua", "6jub", "6juc", "6jud" ]

9

[ "PUB00035389" ]

[ "16522806" ]

[ "Crystal structure of Homo sapiens PTD012 reveals a zinc-containing hydrolase fold." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota", "marine metagenome", "unclassified Caldilineaceae" ]

[ 2566, 1, 3 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 13, 3, 7 ]

6

true

Domain

Ester hydrolase C11orf54, Domain of unknown function DUF1907

C11orf54_DUF1907

5

IPR015024

15,024

PoNi, N-terminal

PoNi_N

Domain

900

false

This entry represents the N-terminal domain of the PoNe immunity proteins (PoNi), which antagonise the DNAse toxin PoNe (Polymorphic Nuclease effector) [ ]. PoNi proteins may directly interact with PoNe.

[]

0

[ "PFAM" ]

[ "PF08928" ]

[ "PoNi_N" ]

[ 900 ]

1

[]

0

[]

0

[ "PUB00099821" ]

[ "31399579" ]

[ "A modular effector with a DNase domain and a marker for T6SS substrates." ]

[ 2019 ]

1

[]

0

null

[ "Anaeromyces robustus", "Bacteria", "Methanimicrococcus stummii" ]

[ 1, 898, 1 ]

3

[]

0

true

Domain

PoNi, N-terminal

PoNi_N

8

IPR015025

15,025

PoNi, C-terminal

PoNi_C

Domain

1,556

false

This entry represents the C-terminal domain of the PoNe immunity proteins (PoNi) which antagonise the DNAse toxin PoNe (Polymorphic Nuclease effector) [ ]. PoNi proteins may directly interact with PoNe [ ].

[]

0

[ "PFAM" ]

[ "PF08929" ]

[ "PoNi_C" ]

[ 1556 ]

1

[]

0

[ "2fef" ]

1

[ "PUB00099821" ]

[ "31399579" ]

[ "A modular effector with a DNase domain and a marker for T6SS substrates." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Methanimicrococcus stummii", "Opisthokonta", "human gut metagenome" ]

[ 1551, 1, 3, 1 ]

4

[]

0

true

Domain

PoNi, C-terminal

PoNi_C

9

IPR015026

15,026

Protein of unknown function DUF1912

DUF1912

Family

398

false

This protein has no known function. It is found in various Streptococcal proteins.

[]

0

[ "PFAM" ]

[ "PF08930" ]

[ "DUF1912" ]

[ 398 ]

1

[]

0

[ "1z0p" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 398 ]

1

[]

0

true

Family

Protein of unknown function DUF1912

DUF1912

1

IPR015027

15,027

Receptor-binding protein of phage tail base-plate Siphoviridae, head

Caudo_bapla_RBP

Domain

159

false

This domain (caudo_bapla_RBP) can be found in a family of proteins expressed from ORF18 of the Lactococcus P2-like phage. This is one of three protein species, shoulders, neck, and head, that form the phage tail base-plate. In the overall structure this head domain exists as six trimers, and is necessary for specific r...

[]

0

[ "PFAM" ]

[ "PF08931" ]

[ "Caudo_bapla_RBP" ]

[ 159 ]

1

[]

0

[ "1zru", "2bsd", "2bse", "2f0c", "2fsd", "2wzp", "2x53", "3d8m", "3da0", "3ejc", "3hg0", "3u6x", "4hem", "4hep", "4ios", "4v5i", "4v96", "6zig", "6zih", "6zjj" ]

20

[ "PUB00054437" ]

[ "20351260" ]

[ "Structure of lactococcal phage p2 baseplate and its mechanism of activation." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 27, 132 ]

2

[]

0

true

Domain

Receptor-binding protein of phage tail base-plate Siphoviridae, head

Caudo_bapla_RBP

6

IPR015029

15,029

Monodechloroaminopyrrolnitrin synthase PrnB

PrnB

Family

472

false

This protein family includes Monodechloroaminopyrrolnitrin synthase PrnB from Pseudomonas fluorescens and similar bacterial proteins. PrnB is involved in the biosynthesis of the antifungal compound pyrrolnitrin. It is organised into two domains: a small N-terminal capping domain that consists of 7 α-helices and the cor...

[]

0

[ "PFAM" ]

[ "PF08933" ]

[ "PrnB" ]

[ 472 ]

1

[]

0

[ "1zee", "2nwb", "2v7i", "2v7j", "2v7k", "2v7l", "2v7m", "2x66", "2x67", "2x68", "9dfg", "9dfi", "9dfl", "9dfm", "9ea1" ]

15

[ "PUB00049615", "PUB00054440" ]

[ "17924666", "20421301" ]

[ "The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily.", "The ternary complex of PrnB (the second enzyme in the pyrrolnitrin biosynthesis pathway), tryptophan, and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily." ]

[ 2007, 2010 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 468, 4 ]

2

[]

0

true

Family

Monodechloroaminopyrrolnitrin synthase PrnB

PrnB

5

IPR015030

15,030

Retinoblastoma-associated protein, C-terminal

RB_C

Domain

3,881

false

The RB C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and D...

[]

0

[ "PFAM", "SMART" ]

[ "PF08934", "SM01369" ]

[ "Rb_C", "Rb_C" ]

[ 2079, 3735 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-113501", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-174178", "R-HSA-2173796", "R-HSA-2299718", "R-HSA-2559584", "R-HSA-2559585", "R-HSA-6804114", "R-HSA-69200", "R-HSA-69202", "R-HSA-69205", "R-HSA-69231", "R-HSA-69656", "R-HSA-8940973", "R-HSA-9617828", "R-HS...

[ "REACTOME:R-HSA-113501", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-1362300", "REACTOME:R-HSA-1538133", "REACTOME:R-HSA-174178", "REACTOME:R-HSA-2173796", "REACTOME:R-HSA-2299718", "REACTOME:R-HSA-2559584", "REACTOME:R-HSA-2559585", "REACTOME:R-HSA-6804114", "REACTOME:R-HSA-69200", "REACTOME:R-...

45

[ "1gux", "1o9k", "2aze", "2r7g", "3pom", "9dgk", "9dhc", "9dhf" ]

8

[ "PUB00035382" ]

[ "16360038" ]

[ "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3881 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 15, 13, 2, 13, 8 ]

6

true

Domain

Retinoblastoma-associated protein, C-terminal

RB_C

6

IPR015032

15,032

Thoeris protein ThsB, TIR-like domain

ThsB__TIR-like_domain

Domain

3,647

false

This is the TIR-like domain of ThsB proteins, which adopts a Rossmann-like fold [ ]. ThsB is responsible for recognizing phage infection [ ]. Thoeris is a bacterial antiphage defense system, which consists of two genes, thsA and thsB, via NAD+ degradation [ , , , ]. ThsA has robust NAD+ cleavage activity and a two-doma...

[]

0

[ "PFAM" ]

[ "PF08937" ]

[ "ThsB_TIR" ]

[ 3647 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.2.-", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-7342", "PWY-7564", "PWY-8106" ]

[ "EC:3.2.2.-", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-8106" ]

7

[ "3hyn", "6lhy", "8fz9", "8v6t", "8wcf", "9b7d" ]

6

[ "PUB00044760", "PUB00097806", "PUB00101117", "PUB00101118", "PUB00160037" ]

[ "18327267", "29371424", "32499527", "34853457", "38924412" ]

[ "Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins.", "Systematic discovery of antiphage defense systems in the microbial pangenome.", "Structural and functional evidence of bacterial antiphage protection by Thoeris defense system v...

[ 2008, 2018, 2020, 2021, 2024 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 132, 3405, 14, 16, 80 ]

5

[]

0

true

Domain

Thoeris protein ThsB, TIR-like domain

ThsB__TIR-like_domain

8

IPR015033

15,033

HBS1-like protein, N-terminal

HBS1-like_N

Domain

3,661

false

This domain is found at the N terminus of HBS1 proteins. It interacts with the ribosomal protein rpS3 at the mRNA entry site [ ].

[]

0

[ "PFAM" ]

[ "PF08938" ]

[ "HBS1_N" ]

[ 3661 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.5.-", "R-DME-429958", "R-HSA-429958", "R-MMU-429958", "R-RNO-429958", "R-SCE-156842", "R-SCE-3371511", "R-SCE-6798695", "R-SCE-8876725", "R-SPO-156842", "R-SPO-3371511", "R-SPO-6798695", "R-SPO-8876725" ]

[ "EC:3.6.5.-", "REACTOME:R-DME-429958", "REACTOME:R-HSA-429958", "REACTOME:R-MMU-429958", "REACTOME:R-RNO-429958", "REACTOME:R-SCE-156842", "REACTOME:R-SCE-3371511", "REACTOME:R-SCE-6798695", "REACTOME:R-SCE-8876725", "REACTOME:R-SPO-156842", "REACTOME:R-SPO-3371511", "REACTOME:R-SPO-6798695", ...

13

[ "1ufz", "3izq", "3mca", "5lzw", "5lzx", "5lzy", "5lzz", "5m1j" ]

8

[ "PUB00066737" ]

[ "21623367" ]

[ "Structure of the no-go mRNA decay complex Dom34-Hbs1 bound to a stalled 80S ribosome." ]

[ 2011 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3661 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1, 10, 7, 2, 10, 1, 1 ]

8

true

Domain

HBS1-like protein, N-terminal

HBS1-like_N

8

IPR015034

15,034

Basophilic leukemia-expressed protein Bles03-like

Bles03

Family

2,303

false

This family includes Basophilic leukemia-expressed protein Bles03 (also known as UPF0696 protein C11orf68, ) and various uncharacterised proteins of unknown function from eukaryotes, bacteria and archaea. Bles03 shows a two-layer sandwich architecture with a a nine-stranded β-sheet, three α-helices on each side and one...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08939", "PTHR31977" ]

[ "Bles03", "" ]

[ 2260, 2131 ]

2

[]

0

[ "1ztp", "2q4k" ]

2

[ "PUB00039014", "PUB00100679" ]

[ "16511166", "25062915" ]

[ "The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03.", "Genome-wide search for eliminylating domains reveals novel function for BLES03-like proteins." ]

[ 2005, 2014 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Fadolivirus FV1/VV64", "metagenomes" ]

[ 100, 73, 2118, 1, 11 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 7, 1, 1, 2, 1 ]

5

true

Family

Basophilic leukemia-expressed protein Bles03-like

Bles03

6

IPR015035

15,035

Domain of unknown function DUF1918

DUF1918

Domain

3,146

false

This domain is found in various hypothetical bacterial proteins, and has no known function. It adopts SH3-like β-barrel with an additional C-terminal α-helix that packs on one side of the barrel [ ].

[]

0

[ "PFAM" ]

[ "PF08940" ]

[ "DUF1918" ]

[ 3146 ]

1

[]

0

[ "2a7y" ]

1

[ "PUB00039180" ]

[ "16885468" ]

[ "Solution structure of the conserved hypothetical protein Rv2302 from Mycobacterium tuberculosis." ]

[ 2006 ]

1

[]

0

null

[ "Aspergillaceae", "Bacteria", "Halobacteriales", "metagenomes" ]

[ 22, 3115, 4, 5 ]

4

[]

0

true

Domain

Domain of unknown function DUF1918

DUF1918

5

IPR015036

15,036

E3 ubiquitin-protein ligase NRDP1

NRDP1

Domain

1,479

false

NRDP1 acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins [ , ].

[ "GO:0061630", "GO:0016567" ]

[ "ubiquitin protein ligase activity", "protein ubiquitination" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF08941" ]

[ "USP8_interact" ]

[ 1479 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-DRE-1358803", "R-DRE-983168", "R-HSA-1358803", "R-HSA-983168", "R-MMU-1358803", "R-MMU-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-DRE-1358803", "REACTOME:R-DRE-983168", "REACTOME:R-HSA-1358803", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-1358803", "REACTOME:R-MMU-983168" ]

8

[ "2fzp", "2gwf", "2ogb" ]

3

[ "PUB00086629", "PUB00086630" ]

[ "19483718", "12411582" ]

[ "The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon.", "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3." ]

[ 2009, 2002 ]

2

[]

0

null

[ "Chitinophagaceae", "Metazoa" ]

[ 4, 1475 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 7, 2, 4 ]

5

true

Domain

E3 ubiquitin-protein ligase NRDP1

NRDP1

8

IPR015037

15,037

Protein of unknown function DUF1919

DUF1919

Family

582

false

This protein has no known function. It is found in various hypothetical and putative bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08942" ]

[ "DUF1919" ]

[ 582 ]

1

[]

0

[ "2g6t" ]

1

[]

0

[]

0

null

[ "Bacteria", "Methanosarcina mazei", "Pycnococcus provasolii", "metagenomes" ]

[ 572, 1, 1, 8 ]

4

[]

0

true

Family

Protein of unknown function DUF1919

DUF1919

3

IPR015038

15,038

Glutarate 2-hydroxylase GlaH

GlaH

Family

1,517

false

GlaH (also known as CsiD) acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG) in the stationary phase of E.coli. It functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. Other dicarboxylic ...

[ "GO:0005506", "GO:0050498" ]

[ "iron ion binding", "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01083", "NF002814", "PF08943" ]

[ "glutarate_hydroxylase", "PRK02963.1", "CsiD" ]

[ 1020, 1426, 1517 ]

3

[ "EC" ]

[ "1.14.11.64" ]

[ "EC:1.14.11.64" ]

1

[ "1jr7", "2r6s", "6gpe", "6gpn", "6hl8", "6hl9", "8cdf", "9bwu" ]

8

[ "PUB00035377", "PUB00092438" ]

[ "9512707", "30498244" ]

[ "Molecular analysis of the regulation of csiD, a carbon starvation-inducible gene in Escherichia coli that is exclusively dependent on sigma s and requires activation by cAMP-CRP.", "Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate." ]

[ 1998, 2018 ]

2

[]

0

null

[ "Bacteria", "Dikarya", "ecological metagenomes" ]

[ 1507, 2, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutarate 2-hydroxylase GlaH

GlaH

7

IPR015039

15,039

Neutrophil cytosol factor 1, C-terminal

NCF1_C

Domain

1,060

false

NCF1 (also known as NADPH oxidase subunit p47Phox) is one of the cytosolic regulatory components of NADPH oxidase and consists of a PX domain at the N-terminal, two tandem SH3 domains, a polybasic or autoinhibitory region (PBR/AIR, an arginine/lysine rich region) and a proline-rich region at the C-terminal. In the rest...

[]

0

[ "PFAM" ]

[ "PF08944" ]

[ "p47_phox_C" ]

[ 1060 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1222556", "R-HSA-1236973", "R-HSA-3299685", "R-HSA-4420097", "R-HSA-5668599", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013423", "R-MMU-1222556", "R-MMU-1236973", "R-MMU-3299685", "R-MMU-4420097", "R-MMU-5668599", "R-MMU-9013149", "R-MMU-9013404", "R-MMU-9013423", "R-RNO-12225...

[ "REACTOME:R-HSA-1222556", "REACTOME:R-HSA-1236973", "REACTOME:R-HSA-3299685", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-5668599", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013423", "REACTOME:R-MMU-1222556", "REACTOME:R-MMU-1236973", "REACTOME:R-MMU-3299685", "REACTOM...

23

[ "1k4u" ]

1

[ "PUB00020333", "PUB00036164" ]

[ "12169629", "16326715" ]

[ "Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p.", "NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide." ]

[ 2002, 2006 ]

2

[]

0

null

[ "Euteleostomi" ]

[ 1060 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 6, 6 ]

4

true

Domain

Neutrophil cytosol factor 1, C-terminal

NCF1_C

8

IPR015040

15,040

Bcl-x interacting, BH3 domain

Bcl-x_interacting_BH3_dom

Domain

926

false

This domain is a long α helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11 [ ]. This domain is also known as the BH3 domain between residues 146 and 161.

[]

0

[ "PFAM" ]

[ "PF08945" ]

[ "Bclx_interact" ]

[ 926 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-111446", "R-HSA-111453", "R-HSA-193648", "R-HSA-6802952", "R-HSA-8862803", "R-HSA-8952158", "R-HSA-9607240", "R-HSA-9614657", "R-MMU-111446", "R-MMU-111453", "R-MMU-193648", "R-RNO-111446", "R-RNO-111453", "R-RNO-193648" ]

[ "REACTOME:R-HSA-111446", "REACTOME:R-HSA-111453", "REACTOME:R-HSA-193648", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-8862803", "REACTOME:R-HSA-8952158", "REACTOME:R-HSA-9607240", "REACTOME:R-HSA-9614657", "REACTOME:R-MMU-111446", "REACTOME:R-MMU-111453", "REACTOME:R-MMU-193648", "REACTOME:R-RN...

14

[ "1pq1", "2k7w", "2nl9", "2pqk", "2v6q", "2vm6", "2wh6", "2yq6", "2yq7", "3d7v", "3fdl", "3io8", "3io9", "3kj0", "3kj1", "3kj2", "3kz0", "4a1u", "4a1w", "4b4s", "4d2m", "4qvf", "4uf3", "4yj4", "4yk9", "4zie", "4zif", "4zih", "5agw", "5agx", "5c3g", "5vmo"...

49

[ "PUB00029958" ]

[ "14499110" ]

[ "The structure of a Bcl-xL/Bim fragment complex: implications for Bim function." ]

[ 2003 ]

1

[]

0

null

[ "Deuterostomia" ]

[ 926 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 3, 10 ]

4

true

Domain

Bcl-x interacting, BH3 domain

Bcl-x_interacting_BH3_dom

5

IPR015042

15,042

BPS (Between PH and SH2) domain

BPS-dom

Domain

4,527

false

The BPS (Between PH and SH2) domain, comprised of 2 β strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate pept...

[]

0

[ "PFAM" ]

[ "PF08947" ]

[ "BPS" ]

[ 4527 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1306955", "R-BTA-1433557", "R-BTA-186763", "R-BTA-210993", "R-BTA-8853659", "R-BTA-9696273", "R-HSA-1306955", "R-HSA-1433557", "R-HSA-186763", "R-HSA-210993", "R-HSA-74713", "R-HSA-74749", "R-HSA-74751", "R-HSA-8853659", "R-HSA-9607240", "R-HSA-9648895", "R-HSA-9696273", "R-...

[ "REACTOME:R-BTA-1306955", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-186763", "REACTOME:R-BTA-210993", "REACTOME:R-BTA-8853659", "REACTOME:R-BTA-9696273", "REACTOME:R-HSA-1306955", "REACTOME:R-HSA-1433557", "REACTOME:R-HSA-186763", "REACTOME:R-HSA-210993", "REACTOME:R-HSA-74713", "REACTOME:R-HS...

43

[ "2auh" ]

1

[ "PUB00035363" ]

[ "16246733" ]

[ "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14." ]

[ 2005 ]

1

[]

0

null

[ "Bilateria", "Roseburia inulinivorans DSM 16841" ]

[ 4526, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 25, 9, 9, 17 ]

4

true

Domain

BPS (Between PH and SH2) domain

BPS-dom

9

IPR015043

15,043

Bacteriophage PRD1, P5, spike N-terminal

Phage_PRD1_P5_spike_N

Domain

16

false

This domain is found at the N terminus of bacteriophage PRD1 spike protein P5. The spike structure of bacteriophage PRD1 is comprised of proteins P2, P5, and P31. P5 is an elongated multidomain trimer. The C-terminal fragment of P5 appears to contain the residues responsible for the trimerization of the protein, wherea...

[]

0

[ "PFAM" ]

[ "PF08948" ]

[ "PRD1_P5_spike_N" ]

[ 16 ]

1

[]

0

[ "1w8x", "6q5u" ]

2

[ "PUB00032209", "PUB00088279" ]

[ "15525981", "10956048" ]

[ "Insights into assembly from structural analysis of bacteriophage PRD1.", "Assembly of bacteriophage PRD1 spike complex: role of the multidomain protein P5." ]

[ 2004, 2000 ]

2

[]

0

null

[ "Alphatectivirus" ]

[ 16 ]

1

[]

0

true

Domain

Bacteriophage PRD1, P5, spike N-terminal

Phage_PRD1_P5_spike_N

2

IPR015044

15,044

Bacteriophage PRD1, spike protein P5, C-terminal

Phage_PRD1_P5_C

Domain

8

false

This domain is found at the C terminus of bacteriophage PRD1 spike protein P5. The spike structure of bacteriophage PRD1 is comprised of proteins P2, P5, and P31. P5 is an elongated multidomain trimer. The C-terminal fragment of P5 appears to contain the residues responsible for the trimerization of the protein, wherea...

[]

0

[ "PFAM" ]

[ "PF08949" ]

[ "PRD1_P5_C" ]

[ 8 ]

1

[]

0

[ "1yq5", "1yq6", "1yq8", "6q5u" ]

4

[ "PUB00032209", "PUB00088279" ]

[ "15525981", "10956048" ]

[ "Insights into assembly from structural analysis of bacteriophage PRD1.", "Assembly of bacteriophage PRD1 spike complex: role of the multidomain protein P5." ]

[ 2004, 2000 ]

2

[]

0

null

[ "Alphatectivirus" ]

[ 8 ]

1

[]

0

true

Domain

Bacteriophage PRD1, spike protein P5, C-terminal

Phage_PRD1_P5_C

3

IPR015045

15,045

Mannosyltransferase/phosphorylase 1-like, Leishmania

MPT-1-like_LmxM

Family

783

false

This entry represents a group of proteins predominantly found in bacteria and in the eukaryote Leishmania, including a dual-activity mannosyltransferase/phosphorylases MTP-1 from Leishmania mexicana ( ). MTPs catalyse both the sugar nucleotide-dependent biosynthesis and phosphorolytic turnover of mannogen. These protei...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08950", "PTHR37036" ]

[ "DUF1861", "" ]

[ 783, 777 ]

2

[]

0

[ "2b4w", "6q4w", "6q4x", "6q4y", "6q4z", "6q50" ]

6

[ "PUB00100957" ]

[ "31513773" ]

[ "A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 608, 169, 6 ]

3

[]

0

true

Family

Mannosyltransferase/phosphorylase 1-like, Leishmania

MPT-1-like_LmxM

9

IPR015046

15,046

Lactococcin-A immunity protein-like

LciA_Immunity-like

Family

2,581

false

Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species [ ]. To protect themselves from the bactericidal activity of this molecule they co-express an immunity protein. This entry represents Lactococcin-A immunity protein from Lactococcus lactis and similar proteins predominantly found...

[ "GO:0030153" ]

[ "bacteriocin immunity" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08951" ]

[ "EntA_Immun" ]

[ 2581 ]

1

[]

0

[ "1tdp", "2bl7", "2bl8", "2fu2", "2k19", "2zrr", "5lfi", "8hfs" ]

8

[ "PUB00032784", "PUB00033829", "PUB00044975", "PUB00044976", "PUB00099932" ]

[ "15753083", "15611086", "12427956", "17586105", "27808503" ]

[ "1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A.", "The C-terminal domain of pediocin-like antimicrobial peptides (class IIa bacteriocins) is involved in specific recognition of the C-terminal ...

[ 2005, 2005, 2002, 2007, 2016 ]

5

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 2578, 3 ]

2

[]

0

true

Family

Lactococcin-A immunity protein-like

LciA_Immunity-like

2

IPR015047

15,047

Synaptojanin-1/2, RNA recognition motif

SYNJ1/2_RRM

Domain

4,140

false

This domain represents the RNA recognition motif found in Synaptojanin proteins. Synaptojanins are phosphoinositide phosphatases known to play an important role in vesicle recycling by promoting the uncoating of clathrin following synaptic vesicle uptake [ , , , , ]. Synaptojanin-1 contains an N-terminal domain homolog...

[]

0

[ "PFAM", "SMART" ]

[ "PF08952", "SM01165" ]

[ "DUF1866", "DUF1866" ]

[ 4136, 4106 ]

2

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.36", "GenProp1229", "GenProp1395", "GenProp1509", "GenProp1605", "PWY-6368", "R-CEL-1660499", "R-CEL-1855183", "R-CEL-1855204", "R-CEL-8856828", "R-HSA-1660499", "R-HSA-1855183", "R-HSA-1855204", "R-HSA-8856828", "R-MMU-1660499", "R-MMU-1855183", "R-MMU-1855204", "R-MMU-8856...

[ "EC:3.1.3.36", "GP:GenProp1229", "GP:GenProp1395", "GP:GenProp1509", "GP:GenProp1605", "METACYC:PWY-6368", "REACTOME:R-CEL-1660499", "REACTOME:R-CEL-1855183", "REACTOME:R-CEL-1855204", "REACTOME:R-CEL-8856828", "REACTOME:R-HSA-1660499", "REACTOME:R-HSA-1855183", "REACTOME:R-HSA-1855204", "...

22

[ "1ufw", "2dnr" ]

2

[ "PUB00084648", "PUB00084649", "PUB00084747", "PUB00084748", "PUB00084749", "PUB00084750", "PUB00084752", "PUB00084754" ]

[ "10931870", "27559170", "9428629", "10542231", "21932368", "21316588", "9788876", "12699622" ]

[ "Mutations in synaptojanin disrupt synaptic vesicle recycling.", "Phosphorylation of Synaptojanin Differentially Regulates Endocytosis of Functionally Distinct Synaptic Vesicle Pools.", "Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with...

[ 2000, 2016, 1997, 1999, 2012, 2011, 1998, 2003 ]

8

[ "IPR000504" ]

[ "IPR034971", "IPR034973" ]

1

2

0

[ "Eukaryota" ]

[ 4140 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 50, 2, 8, 12, 24 ]

6

true

Domain

Synaptojanin-1/2, RNA recognition motif

SYNJ1/2_RRM

1

IPR015049

15,049

Trimerisation motif

Trimer_CC

Domain

330

false

This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins [ ]. Coronins are evoluntionarily conserved proteins, mainly involved in actin cytoskeleton organisation [ ].

[]

0

[ "PFAM" ]

[ "PF08954" ]

[ "Trimer_CC" ]

[ 330 ]

1

[ "REACTOME" ]

[ "R-HSA-9636383" ]

[ "REACTOME:R-HSA-9636383" ]

1

[ "2akf" ]

1

[ "PUB00035387", "PUB00063896" ]

[ "16172398", "18925370" ]

[ "A conserved trimerization motif controls the topology of short coiled coils.", "Molecular phylogeny and evolution of the coronin gene family." ]

[ 2005, 2008 ]

2

[]

0

null

[ "Bilateria" ]

[ 330 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 6, 5 ]

3

true

Domain

Trimerisation motif

Trimer_CC

6

IPR015050

15,050

Bypass of forespore C, C-terminal

BofC_C

Domain

1,469

false

BofC (bypass of forespore C) protein acts negatively on inter-compartmental signalling of pro-sigma(K) processing in the sigma(K)-checkpoint of Bacillus subtilis. This is achieved through its interaction with SpoIV inhibiting autoproteolysis of the latter which leads to a delay in proteolytic cleavage of pro-sigma(K) [...

[]

0

[ "PFAM" ]

[ "PF08955" ]

[ "BofC_C" ]

[ 1469 ]

1

[]

0

[ "2bw2", "7xt1" ]

2

[ "PUB00035362", "PUB00097433" ]

[ "16049010", "10931291" ]

[ "The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus.", "BofC negatively regulates SpoIVB-mediated signalling in the Bacillus subtilis sigmaK-checkpoint." ]

[ 2005, 2000 ]

2

[]

0

null

[ "Bacteria", "Myoviridae sp. ctLx49", "bioreactor metagenome" ]

[ 1462, 1, 6 ]

3

[]

0

true

Domain

Bypass of forespore C, C-terminal

BofC_C

4

IPR015051

15,051

Protein YoaG

YoaG

Family

745

false

This entry represents a group of uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08956" ]

[ "DUF1869" ]

[ 745 ]

1

[]

0

[ "1nei" ]

1

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "metagenomes" ]

[ 742, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein YoaG

YoaG

8

IPR015053

15,053

Protein of unknown function DUF1871

DUF1871

Family

789

false

This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.

[]

0

[ "PFAM" ]

[ "PF08958" ]

[ "DUF1871" ]

[ 789 ]

1

[]

0

[ "1u84", "3r2x" ]

2

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "bioreactor metagenome" ]

[ 787, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF1871

DUF1871

1

IPR015055

15,055

STIV B116-like

STIV_B116-like

Family

220

false

The sulfolobus turreted icosahedral virus (STIV) infects Sulfolobus species found in the hot springs of Yellowstone National Park. It has 37 ORFs including B116, whose function is unknown. The structure of B116 reveals a fold consisting of a five-stranded β-sheet flanked on one side by three α helices. Two subunits com...

[]

0

[ "PFAM" ]

[ "PF08960" ]

[ "STIV_B116-like" ]

[ 220 ]

1

[]

0

[ "2j6b", "2j6c", "2j85", "2x4i", "6scf", "8y6z", "8y7f", "8y7g" ]

8

[ "PUB00041899" ]

[ "17336360" ]

[ "A new DNA binding protein highly conserved in diverse crenarchaeal viruses." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Viruses", "metagenomes" ]

[ 20, 168, 27, 5 ]

4

[]

0

true

Family

STIV B116-like

STIV_B116-like

5

IPR015056

15,056

Nuclear receptor-binding factor 2, C-terminal

NRBF2_C

Domain

1,070

false

Nuclear receptor-binding factor 2 (NRBF2) plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosph...

[ "GO:0006914" ]

[ "autophagy" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF08961" ]

[ "NRBF2" ]

[ 1070 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-383280", "R-MMU-383280", "R-RNO-383280" ]

[ "REACTOME:R-HSA-383280", "REACTOME:R-MMU-383280", "REACTOME:R-RNO-383280" ]

3

[ "9wt3" ]

1

[ "PUB00078727", "PUB00078728" ]

[ "10786636", "24849286" ]

[ "Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.", "NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity." ]

[ 2000, 2014 ]

2

[]

0

null

[ "Chordata" ]

[ 1070 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 1, 5 ]

4

true

Domain

Nuclear receptor-binding factor 2, C-terminal

NRBF2_C

8

IPR015057

15,057

Rv2632c-like

Family

2,719

false

This entry includes a set of Actinobacterial proteins, including Rv2632c from Mycobacterium tuberculosis that is strongly implicated in the onset of non-replicating persistence, and thereby latent tuberculosis. Rv2632c contains a dsRBD-like (2 layers α/β) fold (PDBe:2fgg). It shares remarkable similarity with bacterial...

[]

0

[ "PFAM" ]

[ "PF08962" ]

[ "Rv2632c-like" ]

[ 2719 ]

1

[]

0

[ "2fgg", "4wpy", "4wsp" ]

3

[ "PUB00097447" ]

[ "25831534" ]

[ "A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2717, 2 ]

2

[]

0

true

Family

Rv2632c-like

5

IPR015059

15,059

Calcium-dependent cell adhesion molecule, N-terminal

Ca_cell_adhesion_N_dom

Domain

269

false

This entry represents the N-terminal domain of the calcium-dependent cell adhesion molecule 1 (CAD-1) from Dictyostelium. CAD-1 mediates calcium-dependent cell-cell adhesion during the early stage of development [ ]. This domain is also found in Spherulin-3A protein from Physarum polycephalum [ ].

[ "GO:0098609", "GO:0016020" ]

[ "cell-cell adhesion", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF08964" ]

[ "Crystall_3" ]

[ 269 ]

1

[]

0

[ "1ag4", "1hdf", "1yhp", "2b1o", "3ent", "3enu", "5z6d", "5z6e" ]

8

[ "PUB00021124", "PUB00053894" ]

[ "9281431", "8663243" ]

[ "Ca2+-loaded spherulin 3a from Physarum polycephalum adopts the prototype gamma-crystallin fold in aqueous solution.", "Molecular cloning and characterization of DdCAD-1, a Ca2+-dependent cell-cell adhesion molecule, in Dictyostelium discoideum." ]

[ 1997, 1996 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 210, 58, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Calcium-dependent cell adhesion molecule, N-terminal

Ca_cell_adhesion_N_dom

4

IPR015060

15,060

Aca2/YdiL-like

Aca2_YdiL-like

Family

711

false

This family includes Aca2 repressor from Pectobacterium phage ZF40, the uncharacterised protein YdiL from Escherichia coli and similar sequences found in tailed bacteriophages, proteobacteria and actinomycetes. Aca2 regulates the transcription and translation of phage anti-CRISPR acrIF8 gene through DNA binding to 2 in...

[]

0

[ "PFAM" ]

[ "PF08965" ]

[ "Aca2_YdiL" ]

[ 711 ]

1

[]

0

[ "1s4k", "7b5j", "7ezy", "7vjo", "7vjp", "7vjq", "8w35" ]

7

[ "PUB00158950", "PUB00158951", "PUB00158952" ]

[ "31428783", "34756887", "38987591" ]

[ "The autoregulator Aca2 mediates anti-CRISPR repression.", "Structural basis for anti-CRISPR repression mediated by bacterial operon proteins Aca1 and Aca2.", "Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein." ]

[ 2019, 2021, 2024 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "unclassified sequences" ]

[ 704, 5, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Aca2/YdiL-like

Aca2_YdiL-like

3

IPR015061

15,061

Domain of unknown function DUF1882

DUF1882

Domain

290

false

This domain is found in a set of hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08966" ]

[ "DUF1882" ]

[ 290 ]

1

[]

0

[ "2atz" ]

1

[]

0

[]

0

null

[ "Epsilonproteobacteria", "ecological metagenomes" ]

[ 283, 7 ]

2

[]

0

true

Domain

Domain of unknown function DUF1882

DUF1882

8

IPR015062

15,062

Protein of unknown function DUF1885

DUF1885

Family

665

false

This family consists of hypothetical proteins produced by Bacilli.

[]

0

[ "PFAM" ]

[ "PF08968" ]

[ "DUF1885" ]

[ 665 ]

1

[]

0

[ "1t6a" ]

1

[]

0

[]

0

null

[ "Bacillales" ]

[ 665 ]

1

[]

0

true

Family

Protein of unknown function DUF1885

DUF1885

8

IPR015063

15,063

USP8 dimerisation domain

USP8_dimer

Domain

7,557

false

This domain is found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises [ ]. It is also found in other proteins, including AMSH-like protease and STAM-binding protein.

[]

0

[ "PFAM" ]

[ "PF08969" ]

[ "USP8_dimer" ]

[ 7557 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.-", "R-DDI-5689901", "R-HSA-1358803", "R-HSA-4641263", "R-HSA-5689880", "R-HSA-5689901", "R-HSA-6807004", "R-MMU-1358803", "R-MMU-4641263", "R-MMU-5689880", "R-MMU-5689901", "R-MMU-6807004", "R-RNO-5689901", "R-SPO-5689901" ]

[ "EC:3.4.19.-", "REACTOME:R-DDI-5689901", "REACTOME:R-HSA-1358803", "REACTOME:R-HSA-4641263", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-5689901", "REACTOME:R-HSA-6807004", "REACTOME:R-MMU-1358803", "REACTOME:R-MMU-4641263", "REACTOME:R-MMU-5689880", "REACTOME:R-MMU-5689901", "REACTOME:R-MMU-680...

14

[ "2a9u", "2xze", "8y9a", "9le4" ]

4

[ "PUB00039203" ]

[ "17035239" ]

[ "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota", "Streptomyces javensis" ]

[ 7556, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Ze...

[ 5, 15, 5, 32, 9, 1, 8, 9, 1, 14 ]

10

true

Domain

USP8 dimerisation domain

USP8_dimer

2

IPR015067

15,067

Protein of unknown function DUF1893, TM1506-like

DUF1893_TM1506-like

Family

565

false

This group of functionally uncharacterised bacterial proteins includes TM1506 from Thermotoga maritima ( ), which has a cytidine deaminase-like fold. It binds an unknown ligand in the crystal structure. The protein is ADP-ribosylated at a conserved aspartate [ ].

[]

0

[ "PFAM" ]

[ "PF08973" ]

[ "TM1506" ]

[ 565 ]

1

[]

0

[ "1vk9", "9e9a" ]

2

[ "PUB00046766" ]

[ "18275082" ]

[ "Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Tritrichomonas musculus", "ecological metagenomes" ]

[ 3, 550, 2, 10 ]

4

[]

0

true

Family

Protein of unknown function DUF1893, TM1506-like

DUF1893_TM1506-like

7

IPR015068

15,068

Protein of unknown function DUF1877

DUF1877

Family

2,372

false

This entry represents Protein YfbM from Escherichia coli (strain K12) and similar proteins mainly found in bacteria. The structure of YfbM has been solved, showing α/β/α layers with an antiparallel β-sheet. Although this protein is been suggested to be a binding site for peptide nucleic acids (PNAs, species-selective a...

[]

0

[ "PFAM" ]

[ "PF08974" ]

[ "DUF1877" ]

[ 2372 ]

1

[]

0

[ "1ryl" ]

1

[ "PUB00099930" ]

[ "24558473" ]

[ "Species-selective killing of bacteria by antimicrobial peptide-PNAs." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanimicrococcus", "metagenomes" ]

[ 2357, 5, 4, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1877

DUF1877

7

IPR015069

15,069

2H-phosphodiesterase-like, Domain of unknown function DUF1868

2H-PEstase_DUF1868

Domain

1,083

false

This presumed domain is found in a group of 2H-phosphodiesterases predominantly from bacteria. Its presence in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses and these appe...

[]

0

[ "PFAM" ]

[ "PF08975" ]

[ "2H-phosphodiest" ]

[ 1083 ]

1

[]

0

[ "2fsq" ]

1

[ "PUB00013642" ]

[ "12466548" ]

[ "Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 805, 260, 12, 6 ]

4

[]

0

true

Domain

2H-phosphodiesterase-like, Domain of unknown function DUF1868

2H-PEstase_DUF1868

6

IPR015070

15,070

DJBP, EF-hand domain

EF_hand_DJBP

Domain

1,266

false

This domain is found in DJ binding protein DJBP. This domain is found in DJ binding protein DJBP. DJBP or EF-hand calcium-binding domain-containing protein 6 is a DJ-1-binding protein that negatively regulates the androgen receptor by recruiting the histone deacetylase complex. Protein DJ-1 antagonises this inhibition ...

[]

0

[ "PFAM" ]

[ "PF08976" ]

[ "EF-hand_11" ]

[ 1266 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3928664", "R-BTA-445355", "R-BTA-5627123", "R-HSA-3928663", "R-HSA-3928664", "R-HSA-416572", "R-HSA-445355", "R-HSA-5625740", "R-HSA-5625900", "R-HSA-5627117", "R-HSA-5627123", "R-MMU-445355", "R-MMU-5627123", "R-RNO-445355", "R-RNO-5627123" ]

[ "REACTOME:R-BTA-3928664", "REACTOME:R-BTA-445355", "REACTOME:R-BTA-5627123", "REACTOME:R-HSA-3928663", "REACTOME:R-HSA-3928664", "REACTOME:R-HSA-416572", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-5625740", "REACTOME:R-HSA-5625900", "REACTOME:R-HSA-5627117", "REACTOME:R-HSA-5627123", "REACTOME:R...

15

[ "1wlz", "5d67", "7rro", "8i7o", "8i7r", "8iyj", "8otz", "8to0", "9cpb", "9cpc", "9fqr", "9syu", "9szr" ]

13

[ "PUB00053434" ]

[ "12612053" ]

[ "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1266 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 6, 3, 7 ]

4

true

Domain

DJBP, EF-hand domain

EF_hand_DJBP

3

IPR015071

15,071

Bypass-of-forespore C, N-terminal

BOFC_N

Domain

727

false

Bypass of forespore C (BofC) is a monomer made up of two domains, an N-terminal and a C-terminal domain. The N-terminal domain of BofC is composed of a four-stranded β-sheet covered by an α-helix. The β-sheet has a beta2-beta1-beta4-beta3 topology, where strands beta1 and beta2 and strands beta3 and beta4 are connected...

[]

0

[ "PFAM" ]

[ "PF08977" ]

[ "BOFC_N" ]

[ 727 ]

1

[]

0

[ "2bw2", "7xt1" ]

2

[ "PUB00035362" ]

[ "16049010" ]

[ "The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria" ]

[ 727 ]

1

[]

0

true

Domain

Bypass-of-forespore C, N-terminal

BOFC_N

7

IPR015072

15,072

Outer capsid protein VP9/VP10/VP11

VP9/VP10/VP11

Family

120

false

The entry represents proteins with various designations in the seadornavirus group: VP9 in Banna virus, VP10 in Liao ning virus, and VP11 in Kadipiro virus. VP9 is a spike-forming protein that mediates virion attachment to the host cell receptors and plays a major role in cell penetration [ ].

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF08978", "TIGR04237" ]

[ "Reoviridae_Vp9", "seadorna_VP9" ]

[ 38, 120 ]

2

[ "GP" ]

[ "GenProp1016" ]

[ "GP:GenProp1016" ]

1

[ "1w9z", "8k42", "8k44", "8k49", "8w9p", "8w9q" ]

6

[ "PUB00038053" ]

[ "15642258" ]

[ "The structure and function of the outer coat protein VP9 of Banna virus." ]

[ 2005 ]

1

[]

0

null

[ "Seadornavirus", "viral metagenome" ]

[ 119, 1 ]

2

[]

0

true

Family

Outer capsid protein VP9/VP10/VP11

VP9/VP10/VP11

9

IPR015073

15,073

Domain of unknown function DUF1883

DUF1883

Domain

1,491

false

This domain corresponds to a predicted ligand-binding domain of the PPC-like β-sandwich fold. It has been observed in conserved gene neighbourhoods with diverse nucleotide-activated effector and related conflict systems, which potentially recognises invasive molecules and initiates system responses or directly triggers...

[]

0

[ "PFAM" ]

[ "PF08980" ]

[ "DUF1883" ]

[ 1491 ]

1

[]

0

[ "2b1y" ]

1

[ "PUB00097693" ]

[ "32868406" ]

[ "Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Streblomastix strix", "metagenomes" ]

[ 1486, 1, 4 ]

3

[]

0

true

Domain

Domain of unknown function DUF1883

DUF1883

4

IPR015074

15,074

Protein of unknown function DUF1867

DUF1867

Family

457

false

This entry represents Uncharacterized protein MJ0504 and related hypothetical proteins found in various bacteria and archaea. The structure of MTH1675 from Methanobacterium thermoautotrophicum has a three-layer α/β/α structure, similar to that found in the C-terminal domain of pyruvate kinase.

[]

0

[ "PIRSF" ]

[ "PIRSF016138" ]

[ "UCP016138" ]

[ 457 ]

1

[]

0

[ "1t57", "1vp8" ]

2

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 212, 228, 17 ]

3

[]

0

true

Family

Protein of unknown function DUF1867

DUF1867

1

IPR015075

15,075

Acetylaranotin biosynthesis cluster protein L

AtaL

Family

2,223

false

This entry includes acetylaranotin biosynthesis cluster protein L (AtaL) from Aspergillus terreus, which is a non-ribosomal peptide synthetase. It is required for the biosynthesis of the toxin acetylaranotin, which is a disulfide bridged cyclic dipeptide [ ]. There are a number of steps in the biosyntheis of this epipo...

[]

0

[ "PFAM" ]

[ "PF08982" ]

[ "AtaL" ]

[ 2223 ]

1

[]

0

[ "2ffs" ]

1

[ "PUB00086035" ]

[ "23586797" ]

[ "Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Nitrososphaerota", "ecological metagenomes" ]

[ 1154, 1065, 2, 2 ]

4

[]

0

true

Family

Acetylaranotin biosynthesis cluster protein L

AtaL

3

IPR015076

15,076

Vasopressin V1 receptor, C-terminal

V1R_C

Domain

1,255

false

This is the conserved C-terminal domain of Vasopressin V1a/b receptors (V1R), which is involved in receptor trafficking and facilitates the interaction between the intracellular loops of the receptor, the G proteins and coupling to phospholipase C [ , ]. This domain is unstructured and may reflect a conformational plas...

[]

0

[ "PFAM", "SMART" ]

[ "PF08983", "SM01164" ]

[ "V1R_C", "DUF1856" ]

[ 1021, 1195 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-388479", "R-HSA-416476", "R-HSA-5619099", "R-MMU-388479", "R-MMU-416476", "R-RNO-388479", "R-RNO-416476" ]

[ "REACTOME:R-HSA-388479", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-5619099", "REACTOME:R-MMU-388479", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-388479", "REACTOME:R-RNO-416476" ]

7

[ "1ytv" ]

1

[ "PUB00038629", "PUB00098105" ]

[ "16511036", "23830982" ]

[ "A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein.", "Expression of arginine vasotocin receptors in the developing zebrafish CNS." ]

[ 2005, 2013 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 1255 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 5, 5 ]

4

true

Domain

Vasopressin V1 receptor, C-terminal

V1R_C

8

IPR015077

15,077

Domain of unknown function DUF1858

DUF1858

Domain

4,551

false

This protein has no known function. It is found in various hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08984" ]

[ "DUF1858" ]

[ 4551 ]

1

[]

0

[ "2fi0", "2k53", "2k5e" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Trichomonas vaginalis", "metagenomes" ]

[ 121, 4306, 2, 122 ]

4

[]

0

true

Domain

Domain of unknown function DUF1858

DUF1858

3

IPR015078

15,078

DP-EP family

DP-EP

Family

250

false

The DP-EP family of proteins, formerly known as DUF1888 have been shown to catalyse a cleavage of an internal peptide bond [ ].

[]

0

[ "PFAM" ]

[ "PF08985" ]

[ "DP-EP" ]

[ 250 ]

1

[]

0

[ "3n55", "3njf", "3njg", "3njh", "3nji", "3njj", "3njk", "3njl", "3njm", "3njn" ]

10

[ "PUB00062632" ]

[ "22493430" ]

[ "Characterization of member of DUF1888 protein family, self-cleaving and self-assembling endopeptidase." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 249, 1 ]

2

[]

0

true

Family

DP-EP family

DP-EP

1