LiteFold/InterPro · Datasets at Hugging Face

IPR014841

14,841

Rad33

Family

128

false

Rad33 is involved in nucleotide excision repair (NER). NER is the main pathway for repairing DNA lesions induced by UV. Cells deleted for RAD33 display intermediate UV sensitivity that is epistatic with NER [ ].

[]

0

[ "PFAM" ]

[ "PF08730" ]

[ "Rad33" ]

[ 128 ]

1

[]

0

[ "7k04", "7m2u" ]

2

[ "PUB00035454" ]

[ "16595192" ]

[ "Rad33, a new factor involved in nucleotide excision repair in Saccharomyces cerevisiae." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Fungi" ]

[ 4, 124 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Rad33

5

IPR014842

14,842

Iron-regulated transcriptional activator AFT

AFT

Family

1,018

false

AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis. This entry includes the paralogous pair of transcription factors AFT1 and AFT2 [ , ].

[ "GO:0000981", "GO:0010106", "GO:0045944" ]

[ "DNA-binding transcription factor activity, RNA polymerase II-specific", "cellular response to iron ion starvation", "positive regulation of transcription by RNA polymerase II" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF08731" ]

[ "AFT" ]

[ 1018 ]

1

[]

0

[ "4lmg" ]

1

[ "PUB00044902", "PUB00044903" ]

[ "9200812", "12756250" ]

[ "The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.", "Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements." ]

[ 1997, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1018 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Family

Iron-regulated transcriptional activator AFT

AFT

8

IPR014843

14,843

Protein Him1/Fmp52

Him1/Fmp52

Family

1,072

false

Him1 (high induction of mutagenesis protein 1) plays a role in the control of spontaneous and induced mutagenesis [ ]. It is thought to participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage. This entry also includes mitochondrial protein Fmp52, whose func...

[]

0

[ "PFAM" ]

[ "PF08732" ]

[ "HIM1" ]

[ 1072 ]

1

[]

0

[ "2a35" ]

1

[ "PUB00035407" ]

[ "15885712" ]

[ "HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 573, 497, 2 ]

3

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Family

Protein Him1/Fmp52

Him1/Fmp52

5

IPR014844

14,844

PalH/RIM21

PalH

Family

1,355

false

PalH (also known as RIM21) is a transmembrane protein required for proteolytic cleavage of Rim101/PacC transcription factors which are activated by C-terminal proteolytic processing. Rim101/PacC family proteins play a key role in pH-dependent responses and PalH has been implicated as a pH sensor [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08733", "PTHR35779" ]

[ "PalH", "" ]

[ 1355, 1343 ]

2

[]

0

[]

0

[ "PUB00035441" ]

[ "16099830" ]

[ "Arrestin-related proteins mediate pH signaling in fungi." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1355 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2 ]

2

true

Family

PalH/RIM21

PalH

3

IPR014845

14,845

Protein GYD/TTHA1554

GYD/TTHA1554

Family

2,904

false

This entry represents Glutamine synthetase and cystathionine beta-lyase binding protein (TTHA1554) from T. thermophilus. This protein binds to glutamine synthetase and cystathionine beta-lyase. It may be utilised for the efficient use of nitrogen in the global nitrogen regulation of T.thermophilus [ ]. This entry inclu...

[]

0

[ "PFAM" ]

[ "PF08734" ]

[ "GYD" ]

[ 2904 ]

1

[]

0

[]

0

[ "PUB00088183" ]

[ "15893507" ]

[ "Conserved protein TTHA1554 from Thermus thermophilus HB8 binds to glutamine synthetase and cystathionine beta-lyase." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 292, 2446, 17, 149 ]

4

[]

0

true

Family

Protein GYD/TTHA1554

GYD/TTHA1554

8

IPR014847

14,847

FERM adjacent

FA

Domain

29,865

false

This region is found adjacent to Band 4.1 / FERM domains ( ) in a group of animal FERM containing proteins. The region has been hypothesised to play a role in regulatory adaptation, based on similarity to other protein kinase substrates [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF08736", "SM01195" ]

[ "FA", "FA" ]

[ 29320, 29831 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6794361", "R-CEL-182971", "R-CEL-5675221", "R-DME-6794361", "R-HSA-166016", "R-HSA-399719", "R-HSA-399955", "R-HSA-6794361", "R-HSA-8980692", "R-HSA-9008059", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9022699", "R-HSA-9035034", "R-HSA-9662360", "R-HSA-9662361", "R-MMU-166016", ...

[ "REACTOME:R-BTA-6794361", "REACTOME:R-CEL-182971", "REACTOME:R-CEL-5675221", "REACTOME:R-DME-6794361", "REACTOME:R-HSA-166016", "REACTOME:R-HSA-399719", "REACTOME:R-HSA-399955", "REACTOME:R-HSA-6794361", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9008059", "REACTOME:R-HSA-9013148", "REACTOME:R-...

30

[ "6d21" ]

1

[ "PUB00035526" ]

[ "16626485" ]

[ "A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 29865 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 294, 23, 71, 67, 86 ]

7

true

Domain

FERM adjacent

FA

4

IPR014848

14,848

Reduced growth phenotype protein 1

Rgp1

Family

4,641

false

Rgp1 forms heterodimer with Ric1 ( ) which associates with Golgi membranes and functions as a guanyl-nucleotide exchange factor [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08737", "PTHR12507" ]

[ "Rgp1", "" ]

[ 4231, 4586 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6811438", "R-HSA-6811440", "R-HSA-8876198", "R-MMU-6811438", "R-MMU-6811440", "R-MMU-8876198", "R-SCE-6811440", "R-SCE-8876198", "R-SPO-6811440", "R-SPO-8876198" ]

[ "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-6811438", "REACTOME:R-MMU-6811440", "REACTOME:R-MMU-8876198", "REACTOME:R-SCE-6811440", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-6811440", "REACTOME:R-SPO-8876198" ]

10

[ "9ayr" ]

1

[ "PUB00035455" ]

[ "10990452" ]

[ "Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4641 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 3, 2, 2, 1, 4, 4, 1, 1, 12 ]

12

true

Family

Reduced growth phenotype protein 1

Rgp1

9

IPR014849

14,849

EKC/KEOPS complex, subunit Gon7

EKC/KEOPS_Gon7

Family

1,076

false

In Saccharomyces cerevisiae Gon7 is a member of the EKC/KEOPS protein complex. The complex proposed to be involved in transcription and promoting telomere uncapping and telomere elongation and is required for efficient recruitment of transcriptional coactivators [ , ].

[]

0

[ "PFAM" ]

[ "PF08738" ]

[ "Gon7" ]

[ 1076 ]

1

[]

0

[ "4wx8", "4wxa" ]

2

[ "PUB00035406", "PUB00035445" ]

[ "16564010", "16874308" ]

[ "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.", "Yeast homolog of a cancer-testis antigen defines a new transcription complex." ]

[ 2006, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1076 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

EKC/KEOPS complex, subunit Gon7

EKC/KEOPS_Gon7

9

IPR014851

14,851

BCS1, N-terminal

BCS1_N

Domain

8,608

false

This domain is found at the N-terminal of the mitochondrial ATPase BSC1. This domain is responsible for the import and intramitochondrial sorting [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF08740", "SM01024" ]

[ "BCS1_N", "BCS1_N" ]

[ 8575, 8076 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME" ]

[ "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289", "R-HSA-1268020", "R-HSA-9865881" ]

[ "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-9865881" ]

13

[ "6sh3", "6sh4", "6sh5", "6u1y", "6uko", "6ukp", "6uks", "8t14", "8t5u", "8t7u", "8tby", "8ti0", "8tp1", "8tpl", "9gs2", "9gsn", "9gu9" ]

17

[ "PUB00035361" ]

[ "12640110" ]

[ "Mitochondrial protein import: recognition of internal import signals of BCS1 by the TOM complex." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 100, 8455, 43, 10 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 2, 11, 1, 3, 3, 1, 1 ]

9

true

Domain

BCS1, N-terminal

BCS1_N

2

IPR014852

14,852

Uncharacterised protein YwhD

YwhD

Family

1,695

false

The members of this entry are currently uncharacterised. They are around 170 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF08741" ]

[ "YwhD" ]

[ 1695 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "human gut metagenome" ]

[ 1693, 1, 1 ]

3

[]

0

true

Family

Uncharacterised protein YwhD

YwhD

2

IPR014853

14,853

VWF/SSPO/Zonadhesin-like, cysteine-rich domain

VWF/SSPO/ZAN-like_Cys-rich_dom

Domain

20,576

false

The proteins in this entry contained a domain rich in positionally conserved cysteine residues. Most proteins contains 7 or 8 cysteine residues. The domain is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing and .

[]

0

[ "PFAM", "SMART" ]

[ "PF08742", "SM00832" ]

[ "C8", "C8" ]

[ 19399, 19864 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-114608", "R-CFA-216083", "R-CFA-354192", "R-CFA-354194", "R-CFA-372708", "R-CFA-430116", "R-CFA-5674135", "R-CFA-75892", "R-HSA-114608", "R-HSA-140837", "R-HSA-163125", "R-HSA-216083", "R-HSA-354192", "R-HSA-354194", "R-HSA-372708", "R-HSA-430116", "R-HSA-5083625", "R-HSA-50...

[ "REACTOME:R-CFA-114608", "REACTOME:R-CFA-216083", "REACTOME:R-CFA-354192", "REACTOME:R-CFA-354194", "REACTOME:R-CFA-372708", "REACTOME:R-CFA-430116", "REACTOME:R-CFA-5674135", "REACTOME:R-CFA-75892", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-140837", "REACTOME:R-HSA-163125", "REACTOME:R-HSA-216...

58

[ "6n29", "6rbf", "6tm2", "7a5o", "7kwo", "7pmv", "7pnf", "7pov", "7pp6", "7prl", "7qcl", "7qcn", "7qcu", "7wn3", "7wn4", "7wn6", "7wpp", "7wpq", "7wpr", "7wps", "7wqt", "7zwh", "8d3c", "8d3d", "8oer", "8oes", "8qci", "8qsp", "8qtb", "8qtv", "8r0t", "8r1u"...

36

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 20576 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 42, 6, 45, 61, 49 ]

5

true

Domain

VWF/SSPO/Zonadhesin-like, cysteine-rich domain

VWF/SSPO/ZAN-like_Cys-rich_dom

7

IPR014854

14,854

Non-structural maintenance of chromosome element 4, C-terminal

Nse4_C

Domain

4,984

false

Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6 [ ]. This entry represents the highly conserved C-terminal domain which interacts with the head domain of Smc5 [ ].

[]

0

[ "PFAM" ]

[ "PF08743" ]

[ "Nse4_C" ]

[ 4984 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3108214", "R-HSA-3108214", "R-MMU-3108214", "R-RNO-3108214", "R-SCE-3108214", "R-SPO-3108214" ]

[ "REACTOME:R-BTA-3108214", "REACTOME:R-HSA-3108214", "REACTOME:R-MMU-3108214", "REACTOME:R-RNO-3108214", "REACTOME:R-SCE-3108214", "REACTOME:R-SPO-3108214" ]

6

[ "7qcd", "7tve", "7ymd", "7yqh", "8hqs", "8i13", "8t8f", "8wjn" ]

8

[ "PUB00035433", "PUB00095747" ]

[ "15331764", "17005570" ]

[ "Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.", "The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits." ]

[ 2004, 2006 ]

2

[]

0

null

[ "Archaea", "Eukaryota" ]

[ 10, 4974 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 3, 3, 4, 3, 1, 12, 5, 1, 1, 39 ]

12

true

Domain

Non-structural maintenance of chromosome element 4, C-terminal

Nse4_C

9

IPR014855

14,855

Plant transcription factor NOZZLE

NOZZLE

Family

393

false

NOZZLE (also known as SPOROCYTELESS) is a transcription factor that plays a role in patterning the proximal-distal and adaxial-abaxial axes [ , ]. It is an essential factor for ovule development and functions as an adaptor-like transcriptional repressor, recruiting TPL/TPR co-repressors to inhibit TCP transcription fac...

[ "GO:0003700" ]

[ "DNA-binding transcription factor activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF08744" ]

[ "NOZZLE" ]

[ 393 ]

1

[]

0

[]

0

[ "PUB00035431", "PUB00035432", "PUB00095257" ]

[ "12074197", "12183381", "25378179" ]

[ "Arabidopsis transcription factors and the regulation of flowering time: a genomic perspective.", "NOZZLE links proximal-distal and adaxial-abaxial pattern formation during ovule development in Arabidopsis thaliana.", "The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis ovule development....

[ 2002, 2002, 2015 ]

3

[ "IPR040356" ]

[]

1

0

1

[ "Eukaryota" ]

[ 393 ]

1

[ "Arabidopsis thaliana" ]

[ 2 ]

1

true

Family

Plant transcription factor NOZZLE

NOZZLE

9

IPR014856

14,856

RNA-free ribonuclease P

RNA_free_RNase_P

Family

512

false

RNase P catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. The ancient form of RNase P is a ribonucleoprotein consisting of a catalytic RNA and one or more protein subunits. This entry represents a type of protein-only RNase P found in the hyperthermophilic bacterium Aquife...

[]

0

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01078", "PF08745", "PTHR41173", "TIGR03875" ]

[ "RNA_free_RNase_P", "PIN_5", "", "RNA_lig_partner" ]

[ 431, 512, 509, 506 ]

4

[ "EC", "GP" ]

[ "3.1.26.5", "GenProp0898" ]

[ "EC:3.1.26.5", "GP:GenProp0898" ]

2

[ "7e8j", "7e8k", "7e8o", "7f3e", "7og5", "8kd9", "8kda", "8ssf", "8ssg" ]

9

[ "PUB00093747" ]

[ "29073018" ]

[ "Minimal and RNA-free RNase P in Aquifex aeolicus." ]

[ 2017 ]

1

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 345, 154, 13 ]

3

[]

0

true

Family

RNA-free ribonuclease P

RNA_free_RNase_P

1

IPR014857

14,857

Non-structural maintenance of chromosomes element 1, RING C4HC3-type

Nse1_RING_C4HC3-type

Domain

3,391

false

This entry represents the C3HC4-type RING finger domain, also known as vRING or RINGv, a variant of C3H2C3-type RING-H2 finger, found at the C-terminal of Nse1. This domain may play an important role in Rad52-dependent post-replication repair of UV-damaged DNA in Saccharomyces cerevisiae. Saccharomyces cerevisiae Nse1 ...

[]

0

[ "PFAM", "CDD" ]

[ "PF08746", "cd16493" ]

[ "zf-RING-like", "RING-CH-C4HC3_NSE1" ]

[ 3385, 2664 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-3108214", "R-MMU-3108214", "R-RNO-3108214", "R-SCE-3108214", "R-SPO-3108214" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-3108214", "REACTOME:R-MMU-3108214", "REACTOME:R-RNO-3108214", "REACTOME:R-SCE-3108214", "REACTOME:R-SPO-3108214" ]

7

[ "2ct0", "5hvq", "5wy5", "7dg2", "7qcd", "7tve", "7ymd", "7yqh", "8hqs", "8i13", "8wjn" ]

11

[ "PUB00014740", "PUB00014741" ]

[ "12966087", "11927594" ]

[ "Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.", "Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3391 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 4, 2, 2, 2, 1, 5, 4, 1, 1, 4 ]

11

true

Domain

Non-structural maintenance of chromosomes element 1, RING C4HC3-type

Nse1_RING_C4HC3-type

9

IPR014858

14,858

BREX protein BrxB

BrxB

Family

1,844

false

This family includes BREX protein BrxB from Bacillus cereus, which is part of a type 1 BREX (bacteriophage exclusion) system, a system that provides immunity against bacteriophage, which allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA [ ]. The exact function of BrxB is n...

[]

0

[ "PFAM" ]

[ "PF08747" ]

[ "BrxB" ]

[ 1844 ]

1

[]

0

[ "9nv3" ]

1

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "IncJ plasmid R391", "Methanobacteriota", "metagenomes" ]

[ 1691, 2, 2, 1, 132, 16 ]

6

[]

0

true

Family

BREX protein BrxB

BrxB

6

IPR014859

14,859

Phage tail assembly chaperone

Phage_TAC_4

Family

1,094

false

This is a family of phage tail assembly chaperone proteins largely from phage T1 Gp40 [ ].

[]

0

[ "PFAM" ]

[ "PF08748" ]

[ "Phage_TAC_4" ]

[ 1094 ]

1

[]

0

[]

0

[ "PUB00075454" ]

[ "23542344" ]

[ "A conserved spiral structure for highly diverged phage tail assembly chaperones." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "organismal metagenomes" ]

[ 610, 3, 475, 6 ]

4

[]

0

true

Family

Phage tail assembly chaperone

Phage_TAC_4

7

IPR014862

14,862

TrwC relaxase

TrwC

Domain

6,917

false

Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer. TrwC binds to the origin of transfer (oriT) and melts the double helix.

[]

0

[ "PFAM" ]

[ "PF08751" ]

[ "TrwC" ]

[ 6917 ]

1

[ "EC", "EC" ]

[ "5.6.2.-", "5.6.2.3" ]

[ "EC:5.6.2.-", "EC:5.6.2.3" ]

2

[ "1omh", "1osb", "1p4d", "1qx0", "1s6m", "1zm5", "2a0i", "2cdm", "2q7t", "2q7u", "3l57", "3l6t", "4pcb", "5n8o", "8a1b", "8a1c", "9f0x", "9f0y", "9f0z", "9f10", "9f11", "9f12" ]

22

[]

0

[]

[ "IPR014059" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6829, 19, 69 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

TrwC relaxase

TrwC

1

IPR014864

14,864

Transcription factor, NikR, nickel binding C-terminal

TF_NikR_Ni-bd_C

Domain

4,459

false

NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel. This protein corresponds to the C-terminal regulatory domain which contains four nickel binding sites at the tetramer interface [ ].

[]

0

[ "PFAM" ]

[ "PF08753" ]

[ "NikR_C" ]

[ 4459 ]

1

[]

0

[ "1q5v", "1q5y", "2bj1", "2bj3", "2bj7", "2bj8", "2bj9", "2ca9", "2cad", "2caj", "2hza", "2hzv", "2wvb", "2wvc", "2wvd", "2wve", "2wvf", "2y3y", "3bkf", "3bkt", "3bku", "3lgh", "3od2", "3pht", "3qsi", "6mrj" ]

26

[ "PUB00030137" ]

[ "12970756" ]

[ "Crystal structure of the nickel-responsive transcription factor NikR." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1510, 2851, 5, 93 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcription factor, NikR, nickel binding C-terminal

TF_NikR_Ni-bd_C

1

IPR014866

14,866

YfkB-like domain

YfkB

Domain

1,457

false

YfkB is adjacent to YfkA in Bacillus subtilis. In other bacterial species, it is fused to this protein. As YfkA contains a Radical SAM domain it suggests this domain is interacts with them.

[]

0

[ "PFAM" ]

[ "PF08756" ]

[ "YfkB" ]

[ 1457 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Eukaryota", "human gut metagenome" ]

[ 1454, 2, 1 ]

3

[]

0

true

Domain

YfkB-like domain

YfkB

6

IPR014867

14,867

Spore coat protein CotH/Invasin CotH2/3/7

Spore_coat_CotH_CotH2/3/7

Family

7,564

false

Members of this family include the Bacillus subtilis spore coat protein H (CotH). Assembly of CotH requires both CotE and GerE and is required for the correct assembly of both inner and outer layers of the coat. CotH appears to be a structural component of the coat being localised at the interface of the 2 coat layers ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF08757", "PTHR40050" ]

[ "CotH", "" ]

[ 7561, 4768 ]

2

[]

0

[ "5jd9", "5jda" ]

2

[ "PUB00035372", "PUB00035373", "PUB00035374", "PUB00085072", "PUB00099571", "PUB00099572" ]

[ "17114257", "10198031", "14762006", "27185916", "32487760", "24355926" ]

[ "Morphogenesis of the Bacillus anthracis spore.", "Assembly requirements and role of CotH during spore coat formation in Bacillus subtilis.", "Interactions among CotB, CotG, and CotH during assembly of the Bacillus subtilis spore coat.", "Phosphorylation of spore coat proteins by a family of atypical protein ...

[ 2007, 1999, 2004, 2016, 2020, 2014 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 42, 5468, 9, 1756, 289 ]

5

[]

0

true

Family

Spore coat protein CotH/Invasin CotH2/3/7

Spore_coat_CotH_CotH2/3/7

5

IPR014868

14,868

Cadherin prodomain

Cadherin_pro_dom

Domain

7,363

false

Cadherins are a group of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. The folded part of the prosequence (termed the prodomain) shows structural resemblance to cadherin adhesive domains, but lacks all the features known to be importa...

[]

0

[ "PFAM", "SMART" ]

[ "PF08758", "SM01055" ]

[ "Cadherin_pro", "Cadherin_pro" ]

[ 6909, 6965 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-1474228", "R-CFA-216083", "R-CFA-351906", "R-CFA-418990", "R-CFA-9764561", "R-CFA-9766229", "R-CFA-9768727", "R-DRE-1474228", "R-DRE-351906", "R-DRE-418990", "R-DRE-525793", "R-DRE-5626467", "R-DRE-6798695", "R-DRE-6805567", "R-DRE-6809371", "R-DRE-9764561", "R-DRE-9766229", ...

[ "REACTOME:R-CFA-1474228", "REACTOME:R-CFA-216083", "REACTOME:R-CFA-351906", "REACTOME:R-CFA-418990", "REACTOME:R-CFA-9764561", "REACTOME:R-CFA-9766229", "REACTOME:R-CFA-9768727", "REACTOME:R-DRE-1474228", "REACTOME:R-DRE-351906", "REACTOME:R-DRE-418990", "REACTOME:R-DRE-525793", "REACTOME:R-DR...

68

[ "1op4", "1q55", "1q5a", "1q5b", "1q5c" ]

5

[ "PUB00029531" ]

[ "15130472" ]

[ "Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics." ]

[ 2004 ]

1

[]

0

null

[ "Bilateria" ]

[ 7363 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 41, 24, 25 ]

4

true

Domain

Cadherin prodomain

Cadherin_pro_dom

3

IPR014869

14,869

Glycosyltransferase GT-D fold

GT-D

Domain

835

false

This domain is found at the C terminus of proteins such as the probable glycosyltransferase Gly ( ) that also contain the glycosyl transferase domain at the N terminus. It is also found N-terminal in numerous putative glycosyltransferases such as GalT1. GalT1 has been shown to catalyze the third step of Fap1 glycosylat...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF08759", "TIGR03728" ]

[ "GT-D", "glyco_access_1" ]

[ 835, 459 ]

2

[]

0

[ "4pfx", "4phr", "4phs", "5v4a" ]

4

[ "PUB00081880" ]

[ "25023666" ]

[ "The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Catovirus CTV1", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 813, 1, 8, 3, 10 ]

5

[]

0

true

Domain

Glycosyltransferase GT-D fold

GT-D

3

IPR014871

14,871

dUTPase/dCTP pyrophosphatase

dUTPase/dCTP_pyrophosphatase

Family

3,421

false

This entry represents dimeric deoxyuridine triphosphate nucleotidohydrolase (dUTPase) ( ) and phage T4 dCTP pyrophosphatase ( ). dUTPase catalyses the hydrolysis of dUTP to dUMP and pyrophosphate. There are several classes of dUTPases: trimeric dUTPases found in most organisms and homologous monomeric dUTPases, found i...

[]

0

[ "PFAM" ]

[ "PF08761" ]

[ "dUTPase_2" ]

[ 3421 ]

1

[]

0

[ "1ogk", "1ogl", "1w2y", "2cic", "2cje", "2yay", "2yaz", "2yb0", "4dk2", "4dk4", "4dkb", "4dl8", "4dlc", "5mil", "5myd", "5myf", "5myi", "6h4b" ]

18

[ "PUB00032166", "PUB00070194" ]

[ "15364583", "11420444" ]

[ "The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the \"basic module\" for dimeric d(C/U)TPases.", "Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major." ]

[ 2004, 2001 ]

2

[]

[ "IPR016947", "IPR016995" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 63, 2919, 55, 318, 66 ]

5

[]

0

true

Family

dUTPase/dCTP pyrophosphatase

dUTPase/dCTP_pyrophosphatase

5

IPR014872

14,872

Dicistrovirus, capsid-polyprotein, C-terminal

Dicistrovirus_capsid-polyPr_C

Domain

1,326

false

This domain is found in Picornaviruses that include Cripavirus capsid proteins, (which are positive stranded ssRNA viruses) such as Cricket paralysis virus (CRPV). It forms an all β sheet structure [ ].

[]

0

[ "PFAM" ]

[ "PF08762" ]

[ "CRPV_capsid" ]

[ 1326 ]

1

[]

0

[ "1b35", "3nap", "5cdc", "5cdd", "5g52", "5j96", "5j98", "5l7o", "5l7q", "5l8q", "5lk7", "5lk8", "5lsf", "5lwg", "5lwi", "5mqc", "5mup", "5mv5", "5mv6", "5oyp", "6egv", "6egx", "6eh1", "6eiw", "6f5j", "6iic", "6shl", "7al3", "7bc3", "7be9", "7bg8", "7bgk"...

34

[ "PUB00035375" ]

[ "10426956" ]

[ "The crystal structure of cricket paralysis virus: the first view of a new virus family." ]

[ 1999 ]

1

[]

0

null

[ "Arthropoda", "Viruses", "organismal metagenomes" ]

[ 27, 1295, 4 ]

3

[]

0

true

Domain

Dicistrovirus, capsid-polyprotein, C-terminal

Dicistrovirus_capsid-polyPr_C

9

IPR014874

14,874

Staphylocoagulase, N-terminal, subdomain 1

Staphylocoagulase_N

Domain

228

false

This entry represents the N-terminal domain of staphylocoagulase. The C terminus contains a tandem repeat ( ) which does not seem to be required for the procoagulant activity. Staphylococcus aureus secretes a cofactor called staphylocoagulase. Staphylocoagulase is an extracellular protein that forms a complex with huma...

[]

0

[ "PFAM" ]

[ "PF08764" ]

[ "Coagulase" ]

[ 228 ]

1

[]

0

[ "1nu7", "1nu9", "2a1d" ]

3

[ "PUB00029224" ]

[ "14523451" ]

[ "Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria" ]

[ 228 ]

1

[]

0

true

Domain

Staphylocoagulase, N-terminal, subdomain 1

Staphylocoagulase_N

1

IPR014875

14,875

Mor transcription activator

Mor_transcription_activator

Domain

3,823

false

Mor (Middle operon regulator) is a sequence specific DNA binding protein. It mediates transcription activation through its interactions with the C-terminal domains of the alpha and sigma subunits of bacterial RNA polymerase. The N-terminal region of Mor is the dimerisation region, and the C-terminal contains a helix-tu...

[]

0

[ "PFAM" ]

[ "PF08765" ]

[ "Mor" ]

[ 3823 ]

1

[]

0

[ "1rr7" ]

1

[ "PUB00030775" ]

[ "14729670" ]

[ "Crystal structure of the Mor protein of bacteriophage Mu, a member of the Mor/C family of transcription activators." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3696, 5, 79, 43 ]

4

[]

0

true

Domain

Mor transcription activator

Mor_transcription_activator

3

IPR014876

14,876

DEK, C-terminal

DEK_C

Domain

17,873

false

DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C-terminal of human DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [ , ]. This domain...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08766", "PS51998" ]

[ "DEK_C", "DEK_C" ]

[ 17184, 17120 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5250924", "R-HSA-8864260", "R-HSA-9616222", "R-MMU-5250924", "R-MMU-8864260", "R-RNO-5250924", "R-RNO-8864260" ]

[ "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-8864260", "REACTOME:R-HSA-9616222", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-8864260", "REACTOME:R-RNO-5250924", "REACTOME:R-RNO-8864260" ]

7

[ "1q1v", "7z0o", "8kcy", "8kd1", "9l1x", "9l22" ]

6

[ "PUB00030081", "PUB00035379", "PUB00063291", "PUB00095488", "PUB00150946", "PUB00155060", "PUB00155061" ]

[ "15238633", "7504406", "16230460", "25765544", "25387881", "19547974", "27725723" ]

[ "Solution NMR structure of the C-terminal domain of the human protein DEK.", "Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts.", "Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directi...

[ 2004, 1993, 2005, 2015, 2014, 2009, 2016 ]

7

[]

0

null

[ "Eukaryota", "Gelidibacter salicanalis", "organismal metagenomes" ]

[ 17870, 1, 2 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 70, 20, 8, 16, 11, 3, 21, 20, 2, 1, 61 ]

11

true

Domain

DEK, C-terminal

DEK_C

8

IPR014877

14,877

Exportin-1, C-terminal

XPO1_C_dom

Domain

6,315

false

CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This entry represents the C-terminal domain of CRM1. It forms an α helical structure formed by six helical hairpin mot...

[ "GO:0005049" ]

[ "nuclear export signal receptor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF08767", "SM01102" ]

[ "CRM1_C", "CRM1_C" ]

[ 6313, 6120 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-5687128", "R-DME-3769402", "R-DME-450520", "R-DME-69273", "R-DME-9634638", "R-DME-9707616", "R-DME-9856649", "R-HSA-141444", "R-HSA-165054", "R-HSA-168333", "R-HSA-2173788", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-3769402", "R-HSA-450520", "R-HSA-5663220", "R-HSA-5687128", ...

[ "REACTOME:R-DDI-5687128", "REACTOME:R-DME-3769402", "REACTOME:R-DME-450520", "REACTOME:R-DME-69273", "REACTOME:R-DME-9634638", "REACTOME:R-DME-9707616", "REACTOME:R-DME-9856649", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-165054", "REACTOME:R-HSA-168333", "REACTOME:R-HSA-2173788", "REACTOME:R-HS...

54

[ "1w9c", "3gb8", "3gjx", "3m1i", "3nby", "3nbz", "3nc0", "3nc1", "3vyc", "3wyf", "3wyg", "4bsm", "4bsn", "4fgv", "4gmx", "4gpt", "4hat", "4hau", "4hav", "4haw", "4hax", "4hay", "4haz", "4hb0", "4hb2", "4hb3", "4hb4", "4hzk", "4wvf", "5dh9", "5dha", "5dhf"...

95

[ "PUB00032215" ]

[ "15574331" ]

[ "Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 6315 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 2, 6, 3, 13, 4, 1, 5, 7, 1, 1, 39 ]

12

true

Domain

Exportin-1, C-terminal

XPO1_C_dom

2

IPR014878

14,878

THAP4-like, heme-binding domain

THAP4-like_heme-bd

Domain

8,766

false

Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-β-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs) [ ]. This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis...

[]

0

[ "PFAM", "CDD" ]

[ "PF08768", "cd07828" ]

[ "THAP4_heme-bd", "lipocalin_heme-bd-THAP4-like" ]

[ 8765, 7432 ]

2

[]

0

[ "2a13", "2fr2", "2fwv", "2q4n", "3emm", "3ia8", "3wjb", "3wjc", "3wjd", "3wje", "3wjf", "3wjg", "4ymy", "6r3w", "6r3y", "7bbm" ]

16

[ "PUB00040845", "PUB00063678", "PUB00095798", "PUB00095799" ]

[ "17172346", "19938152", "30524950", "17959165" ]

[ "The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.", "The structure and NO binding properties of the nitrophorin-like heme-binding protein from Arabidopsis thaliana gene locus At1g79260.1.", "Human nitrobindin: the firs...

[ 2007, 2010, 2018, 2007 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5696, 2909, 161 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 11, 1, 4, 3, 4, 5, 5 ]

8

true

Domain

THAP4-like, heme-binding domain

THAP4-like_heme-bd

9

IPR014879

14,879

Sporulation initiation factor Spo0A, C-terminal

Spo0A_C

Domain

3,861

false

The response regulator Spo0A is comprised of a phosphoacceptor domain and a transcription activation domain. This domain corresponds to the transcription activation domain and forms an α helical structure comprising of 6 α helices. The structure contains a helix-turn-helix and binds DNA [ , ].

[ "GO:0003700", "GO:0005509", "GO:0006355", "GO:0042173", "GO:0005737" ]

[ "DNA-binding transcription factor activity", "calcium ion binding", "regulation of DNA-templated transcription", "regulation of sporulation resulting in formation of a cellular spore", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF08769" ]

[ "Spo0A_C" ]

[ 3861 ]

1

[]

0

[ "1fc3", "1lq1" ]

2

[ "PUB00014650", "PUB00014659" ]

[ "11069648", "12176382" ]

[ "The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography.", "DNA complexed structure of the key transcription factor initiating development in sporulating bacteria." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Viruses", "metagenomes" ]

[ 3793, 1, 16, 51 ]

4

[]

0

true

Domain

Sporulation initiation factor Spo0A, C-terminal

Spo0A_C

8

IPR014880

14,880

Sulphur oxidation protein SoxZ

SoxZ_dom

Domain

4,208

false

SoxZ forms an anti parallel β structure and forms a complex with SoxY. Sulphur oxidation occurs at the thiol of a conserved cysteine residue of the SoxY subunit [ ].

[]

0

[ "PFAM" ]

[ "PF08770" ]

[ "SoxZ" ]

[ 4208 ]

1

[]

0

[ "1v8h", "2ox5", "2oxg", "2oxh", "4uwq" ]

5

[ "PUB00035468" ]

[ "11513876" ]

[ "The cysteine residue of the SoxY protein as the active site of protein-bound sulfur oxidation of Paracoccus pantotrophus GB17." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured virus" ]

[ 4097, 5, 105, 1 ]

4

[]

0

true

Domain

Sulphur oxidation protein SoxZ

SoxZ_dom

3

IPR014881

14,881

Nin one binding (NOB1), Zn-ribbon-like domain

NOB1_Zn-bd

Domain

4,468

false

This entry corresponds to a zinc ribbon and is found on the RNA binding protein NOB1.

[]

0

[ "PFAM" ]

[ "PF08772" ]

[ "Zn_ribbon_NOB1" ]

[ 4468 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226" ]

[ "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226" ]

3

[ "2con", "6g18", "6g4s", "6g51", "6g53", "6g5i", "6zuo", "6zxd", "6zxe", "6zxf", "7wtw", "7wtx", "7wtz", "7wu0", "8c01", "8cbj", "8zdc" ]

17

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 4466 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 3, 1, 2, 2, 1, 3, 4, 1, 1, 10 ]

12

true

Domain

Nin one binding (NOB1), Zn-ribbon-like domain

NOB1_Zn-bd

4

IPR014882

14,882

Cathepsin C exclusion

CathepsinC_exc

Domain

1,884

false

Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases. This protein corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini and confers its exopeptidase specificity [ ]. It forms an enclosed β barrel structure compose...

[]

0

[ "PFAM" ]

[ "PF08773" ]

[ "CathepsinC_exc" ]

[ 1884 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.14.1", "R-HSA-204005", "R-HSA-2132295", "R-HSA-5694530", "R-HSA-6798695", "R-MMU-204005", "R-MMU-2132295", "R-MMU-5694530", "R-MMU-6798695", "R-PFA-114608", "R-PFA-2132295", "R-RNO-204005", "R-RNO-2132295", "R-RNO-5694530", "R-RNO-6798695" ]

[ "EC:3.4.14.1", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-2132295", "REACTOME:R-HSA-5694530", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-5694530", "REACTOME:R-MMU-6798695", "REACTOME:R-PFA-114608", "REACTOME:R-PFA-2132295", "REACTOME:R-RNO-204005...

15

[ "1jqp", "1k3b", "2djf", "2djg", "3pdf", "4cdc", "4cdd", "4cde", "4cdf", "4oel", "4oem", "6ic5", "6ic6", "6ic7", "6rn6", "6rn7", "6rn9", "6rne", "6rni" ]

19

[ "PUB00021965", "PUB00097375" ]

[ "11726493", "30978322" ]

[ "Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.", "Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin...

[ 2001, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1884 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 21, 9, 5 ]

4

true

Domain

Cathepsin C exclusion

CathepsinC_exc

8

IPR014883

14,883

VRR-NUC domain

VRR_NUC

Domain

12,057

false

This entry contains proteins with the VRR-NUC domain, such as FAN1, a structure-selective DNA repair nuclease with 5' flap endonuclease activity, involved in the repair of interstrand DNA crosslinks. FAN1 is the only eukaryotic protein with a VRR-NUC domain [ , , ]. This domain is a member of the PD-(D/E)XK nuclease su...

[ "GO:0016788" ]

[ "hydrolase activity, acting on ester bonds" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF08774", "SM00990" ]

[ "VRR_NUC", "VRR_NUC" ]

[ 10320, 10274 ]

2

[ "EC", "REACTOME", "REACTOME" ]

[ "3.1.4.1", "R-HSA-6783310", "R-MMU-6783310" ]

[ "EC:3.1.4.1", "REACTOME:R-HSA-6783310", "REACTOME:R-MMU-6783310" ]

3

[ "4qbl", "4qbn", "4qbo", "4r89", "4r8a", "4rea", "4reb", "4rec", "4ri8", "4ri9", "4ria", "4rib", "4ric", "4rid", "4ry3", "5y7g", "5y7q", "5z6w", "8s5a", "9cl7", "9cma", "9eo1", "9eoa", "9gy0" ]

24

[ "PUB00020736", "PUB00078404", "PUB00103836", "PUB00103838", "PUB00103839" ]

[ "15972856", "24981866", "36226828", "25430771", "29514982" ]

[ "Identification of novel restriction endonuclease-like fold families among hypothetical proteins.", "FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.", "Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific n...

[ 2005, 2014, 2022, 2014, 2018 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 14, 6663, 4207, 1034, 139 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea...

[ 6, 2, 15, 3, 1, 1, 1, 2, 1, 17 ]

10

true

Domain

VRR-NUC domain

VRR_NUC

8

IPR014884

14,884

ParB protein family, C-terminal

ParB_fam_C

Domain

1,143

false

ParB is a component of the par system which mediates accurate DNA partition during cell division. It recognises A-box and B-box DNA motifs. ParB forms an asymmetric dimer with 2 extended helix-turn-helix (HTH) motifs that bind to A-boxes. The HTH motifs emanate from a β sheet coiled coil DNA binding module [ ]. Both DN...

[]

0

[ "PFAM" ]

[ "PF08775" ]

[ "ParB" ]

[ 1143 ]

1

[]

0

[ "1zx4", "2ntz", "3vwb", "3w2a", "3w3c" ]

5

[ "PUB00035443" ]

[ "16306995" ]

[ "Structures of ParB bound to DNA reveal mechanism of partition complex formation." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Punavirus", "metagenomes" ]

[ 1130, 3, 8, 2 ]

4

[]

0

true

Domain

ParB protein family, C-terminal

ParB_fam_C

8

IPR014885

14,885

VASP tetramerisation

VASP_tetra

Domain

4,779

false

Vasodilator-stimulated phosphoprotein (VASP) is an actin cytoskeletal regulatory protein. This region corresponds to the tetramerisation domain which forms a right handed α helical coiled coil structure [ ].

[]

0

[ "PFAM" ]

[ "PF08776" ]

[ "VASP_tetra" ]

[ 4779 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-446353", "R-DDI-5658442", "R-DME-446353", "R-HSA-202433", "R-HSA-376176", "R-HSA-446353", "R-HSA-5663220", "R-MMU-376176", "R-MMU-446353", "R-MMU-5663220", "R-RNO-5663220" ]

[ "REACTOME:R-DDI-446353", "REACTOME:R-DDI-5658442", "REACTOME:R-DME-446353", "REACTOME:R-HSA-202433", "REACTOME:R-HSA-376176", "REACTOME:R-HSA-446353", "REACTOME:R-HSA-5663220", "REACTOME:R-MMU-376176", "REACTOME:R-MMU-446353", "REACTOME:R-MMU-5663220", "REACTOME:R-RNO-5663220" ]

11

[ "1usd", "1use", "6v4n", "6v4o", "7fgb", "7fgc", "7fgd", "7fge", "8e6j", "8e6k", "8gat", "8gau", "8gav", "8yvl", "9cye", "9cyf", "9cyg", "9cyh", "9cyi", "9cyj", "9ejf", "9md2", "9md3", "9md4", "9md5", "9md6", "9o4n", "9o4o", "9o4p", "9o4q", "9o9v" ]

31

[ "PUB00031887" ]

[ "15569942" ]

[ "The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4778, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 54, 2, 22, 13, 28 ]

5

true

Domain

VASP tetramerisation

VASP_tetra

7

IPR014886

14,886

La protein, xRRM domain

La_xRRM

Domain

5,035

false

This entry represents the atypical RRM, named xRRM, found in La and La-related proteins (LaRPs). They belong to an ancient superfamily of proteins that are conserved in nearly all eukaryotes, except Plasmodium. These proteins are broadly involved in critical processes of RNA use and metabolism in the nucleus and the cy...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF08777", "PS51939" ]

[ "RRM_3", "XRRM" ]

[ 4545, 4812 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-73980", "R-HSA-749476" ]

[ "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476" ]

2

[ "1owx", "2lsl", "4erd", "4eyt", "5knw", "6d12", "6d6v", "6tzn", "6u7v", "7lma", "7lmb", "7slp", "7slq", "7uy5", "7uy6", "8gap" ]

16

[ "PUB00029626", "PUB00065263", "PUB00097538", "PUB00097539", "PUB00097540" ]

[ "12842046", "22705372", "23328630", "27679474", "31752575" ]

[ "Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element.", "Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.", "xRRM: a new class of RRM found in the telomerase La family...

[ 2003, 2012, 2013, 2016, 2021 ]

5

[ "IPR000504" ]

[ "IPR034910", "IPR045537" ]

1

2

0

[ "Eukaryota" ]

[ 5035 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 6, 5, 12, 9, 5, 11, 1, 9 ]

10

true

Domain

La protein, xRRM domain

La_xRRM

1

IPR014887

14,887

HIF-1 alpha, C-terminal transactivation domain

HIF-1_CTAD

Domain

3,168

false

This entry corresponds to the C-terminal transactivation domain of HIF1A [ ] and similar sequences from vertebrates. Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays a key role in cellular response to low oxygen tension, as well as in embryonic vascularisation, tumour angiogenesis and pathophysiology of ischaemic d...

[]

0

[ "PFAM" ]

[ "PF08778" ]

[ "HIF-1a_CTAD" ]

[ 3168 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1234158", "R-HSA-1234174", "R-HSA-1234176", "R-HSA-2122947", "R-HSA-452723", "R-HSA-5689880", "R-HSA-6785807", "R-HSA-8849473", "R-HSA-8857538", "R-HSA-8951664", "R-HSA-9664873", "R-HSA-9701898", "R-MMU-1234158", "R-MMU-1234174", "R-MMU-1234176", "R-MMU-5689880", "R-MMU-885753...

[ "REACTOME:R-HSA-1234158", "REACTOME:R-HSA-1234174", "REACTOME:R-HSA-1234176", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-452723", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8849473", "REACTOME:R-HSA-8857538", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9664873", "REACTOME...

24

[ "1h2k", "1h2l", "1h2m", "1l3e", "1l8c", "2ilm", "3d8c", "5jwp", "7lvs", "7qgs" ]

10

[ "PUB00103874", "PUB00103875", "PUB00103876", "PUB00103877" ]

[ "22009797", "30125331", "18658046", "27815979" ]

[ "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.", "A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein.", "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling.", "The facial triad in the α-ke...

[ 2012, 2018, 2008, 2017 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 3168 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 11, 5, 7 ]

4

true

Domain

HIF-1 alpha, C-terminal transactivation domain

HIF-1_CTAD

9

IPR014888

14,888

Structural accessory protein ORF7a, SARS-CoV-like

ORF7a_SARS-CoV-like

Family

528

false

This entry represents the structural accessory protein ORF7a from SARS-CoV-like virus, including SARS-CoV, SARS-CoV-2 and bat SARS-like coronavirus. This entry includes the structural accessory protein ORF7a, also called NS7a, X4 and U122, of Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV) from betacoronavir...

[]

0

[ "PFAM" ]

[ "PF08779" ]

[ "bCoV_NS7A" ]

[ 528 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9678110", "R-HSA-9679509", "R-HSA-9692913", "R-HSA-9692916", "R-HSA-9694322", "R-HSA-9694614", "R-HSA-9705671", "R-HSA-9727281", "R-HSA-9733458", "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9678110", "REACTOME:R-HSA-9679509", "REACTOME:R-HSA-9692913", "REACTOME:R-HSA-9692916", "REACTOME:R-HSA-9694322", "REACTOME:R-HSA-9694614", "REACTOME:R-HSA-9705671", "REACTOME:R-HSA-9727281", "REACTOME:R-HSA-9733458", "REACTOME:R-HSA-9754560" ]

10

[ "1xak", "1yo4", "6w37", "7ci3" ]

4

[ "PUB00032366", "PUB00035458", "PUB00094073", "PUB00095949", "PUB00100395" ]

[ "15642263", "16328780", "17112601", "24995382", "33930332" ]

[ "Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein.", "Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.", "Inhibition of SARS-CoV replication cycle by small in...

[ 2005, 2006, 2007, 2014, 2021 ]

5

[]

[ "IPR044390" ]

0

1

0

[ "Orthocoronavirinae" ]

[ 528 ]

1

[]

0

true

Family

Structural accessory protein ORF7a, SARS-CoV-like

ORF7a_SARS-CoV-like

4

IPR014889

14,889

Transcription factor DP, C-terminal

Transc_factor_DP_C

Domain

5,381

false

The transcription factor DP (dimerization partner) forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [ ] and negatively regulates the G1-S transition.

[]

0

[ "PFAM", "SMART", "CDD" ]

[ "PF08781", "SM01138", "cd14458" ]

[ "DP", "DP", "DP_DD" ]

[ 5375, 5244, 5007 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1538133", "R-BTA-2173796", "R-BTA-69231", "R-BTA-8953750", "R-CEL-1538133", "R-CEL-2173796", "R-DME-1538133", "R-DME-2173796", "R-DME-69231", "R-DME-8953750", "R-HSA-111448", "R-HSA-113501", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-139915", "R-HSA-1538133", "R-HSA-1912408", ...

[ "REACTOME:R-BTA-1538133", "REACTOME:R-BTA-2173796", "REACTOME:R-BTA-69231", "REACTOME:R-BTA-8953750", "REACTOME:R-CEL-1538133", "REACTOME:R-CEL-2173796", "REACTOME:R-DME-1538133", "REACTOME:R-DME-2173796", "REACTOME:R-DME-69231", "REACTOME:R-DME-8953750", "REACTOME:R-HSA-111448", "REACTOME:R-H...

32

[ "2aze", "5tuu", "5tuv" ]

3

[ "PUB00035382", "PUB00088208" ]

[ "16360038", "27825926" ]

[ "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.", "The Interaction Mode of the Acidic Region of the Cell Cycle Transcription Factor DP1 with TFIIH." ]

[ 2005, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5381 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 4, 2, 9, 18, 9, 16, 15 ]

9

true

Domain

Transcription factor DP, C-terminal

Transc_factor_DP_C

2

IPR014891

14,891

DWNN domain

DWNN_domain

Domain

6,687

false

The ~75-residue DWNN (Domain With No Name) domain is highly conserved through eukaryotic species but is absent in prokaryotes. The DWNN domain is found only at the N terminus of the RBBP6 family of proteins which includes: Mammalian RBBP6, a splicing-associated protein that plays a role in the induction of apoptosis an...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF08783", "PS51282", "SM01180" ]

[ "DWNN", "DWNN", "DWNN" ]

[ 6272, 6591, 6246 ]

3

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-9013422", "R-HSA-983168", "R-MMU-9013422", "R-MMU-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-9013422", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-9013422", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

8

[ "2c7h", "6i1d", "7zgp", "7zgr" ]

4

[ "PUB00035393", "PUB00043690" ]

[ "16396680", "15733535" ]

[ "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways.", "SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis." ]

[ 2006, 2005 ]

2

[]

0

null

[ "Eukaryota", "Variovorax guangxiensis" ]

[ 6685, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 2, 488, 2, 4, 4, 1, 12, 7, 1, 1, 18 ]

12

true

Domain

DWNN domain

DWNN_domain

1

IPR014892

14,892

Replication protein A, C-terminal

RPA_C

Domain

5,106

false

This protein corresponds to the C-terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.

[]

0

[ "PFAM" ]

[ "PF08784" ]

[ "RPA_C" ]

[ 5106 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-110312", "R-HSA-110314", "R-HSA-110320", "R-HSA-174437", "R-HSA-176187", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5651801", "R-HSA-5655862", "R-HSA-5656121", "R-HSA-5656169", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693607", "R-HSA-5693616", ...

[ "REACTOME:R-HSA-110312", "REACTOME:R-HSA-110314", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-174437", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-3371511", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5651801", "REACTOME:R-HSA-5655862", "REACTOME:R-H...

126

[ "1dpu", "1z1d", "2pi2", "2z6k", "4mqv", "4ou0", "8rk2", "9mj5" ]

8

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 18, 32, 5053, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 3, 1, 6, 7, 3, 1, 5, 4, 1, 1, 29 ]

12

true

Domain

Replication protein A, C-terminal

RPA_C

7

IPR014893

14,893

Ku, C-terminal

Ku_PK_bind

Domain

4,112

false

The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired. Ku is a component of a multi-protein complex that is involved in the NHEJ. Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Ku also binds R...

[]

0

[ "PFAM" ]

[ "PF08785" ]

[ "Ku_PK_bind" ]

[ 4112 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.4.12", "R-DDI-5693571", "R-DDI-6798695", "R-HSA-164843", "R-HSA-1834949", "R-HSA-3270619", "R-HSA-5693571", "R-HSA-6798695", "R-MMU-5693571", "R-MMU-6798695", "R-SPO-6798695" ]

[ "EC:3.6.4.12", "REACTOME:R-DDI-5693571", "REACTOME:R-DDI-6798695", "REACTOME:R-HSA-164843", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-3270619", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5693571", "REACTOME:R-MMU-6798695", "REACTOME:R-SPO-6798695" ]

11

[ "1q2z", "1rw2", "3ism", "6zh6", "6zha", "6zhe", "7axz", "7k0y", "7k17", "7k1j", "7k1k", "7k1n", "7lsy", "7lt3", "7nfc", "7nfe", "7sgl", "7su3", "7sud", "7z6o", "7z87", "7z88", "7zt6", "7zvt", "7zwa", "7zyg", "8ag4", "8ag5", "8bh3", "8bhv", "8bhy", "8bot"...

45

[ "PUB00030095", "PUB00094626" ]

[ "14672664", "32103174" ]

[ "The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR).", "DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis." ]

[ 2004, 2020 ]

2

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 4, 4108 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 7, 3, 3, 11, 2, 1, 1, 1, 6, 1, 6 ]

11

true

Domain

Ku, C-terminal

Ku_PK_bind

7

IPR014894

14,894

Inner membrane lipoprotein DcrB/EagT6

DcrB/EagT6

Family

3,596

false

DcrB is a bacterial protein required for phages C1 and C6 adsorption [ , ]. It may be involved in the opening or formation of diffusion channels in the outer membrane [ ]. It plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis [ , ]. DcbrB is essential for lipoprote...

[]

0

[ "PFAM" ]

[ "PF08786" ]

[ "DcrB" ]

[ 3596 ]

1

[]

0

[ "1tu1", "6e8a", "6xrb", "6xrf", "6xrr" ]

5

[ "PUB00063631", "PUB00063632", "PUB00094751", "PUB00099567", "PUB00099568", "PUB00100580" ]

[ "8752353", "12558182", "30177742", "30368949", "33431434", "33320089" ]

[ "Genetic control of the resistance to phage C1 of Escherichia coli K-12.", "DcrA and dcrB Escherichia coli genes can control DNA injection by phages specific for BtuB and FhuA receptors.", "Mechanism of loading and translocation of type VI secretion system effector Tse6.", "A synergistic role for two predicte...

[ 1996, 2002, 2018, 2019, 2021, 2020 ]

6

[]

[ "IPR046406" ]

0

1

0

[ "Bacteria", "Candidatus Methanocrinis natronophilus", "Myoviridae sp. ct4xW4", "Opisthokonta", "ecological metagenomes" ]

[ 3589, 1, 1, 2, 3 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane lipoprotein DcrB/EagT6

DcrB/EagT6

5

IPR014895

14,895

Alginate lyase 2

Alginate_lyase_2

Domain

5,593

false

Alginate lyases are enzymes that degrade the linear polysaccharide alignate. They cleave the glycosidic linkage of alignate through a beta-elimination reaction. This region forms an all β fold, which is different to the all α fold of .

[]

0

[ "PFAM" ]

[ "PF08787" ]

[ "Alginate_lyase2" ]

[ 5593 ]

1

[]

0

[ "1j1t", "1uai", "1vav", "2cws", "2z42", "2za9", "2zaa", "2zab", "2zac", "3zpy", "4be3", "4ozx", "4q8k", "4q8l", "5xnr", "5y33", "5zqi", "5zu5", "6ywf", "7c8f", "7c8g", "7ncz", "7nde", "7nl3", "7nm6", "7npp", "7ny3", "7o6h", "7oof", "7ory", "7p25", "7p90"...

59

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "ecological metagenomes" ]

[ 3648, 1925, 11, 9 ]

4

[ "Oryza sativa subsp. japonica" ]

[ 6 ]

1

true

Domain

Alginate lyase 2

Alginate_lyase_2

3

IPR014896

14,896

NHR2-like

NHR2

Domain

5,154

false

Transcriptional activation and repression are required for control of cell proliferation and differentiation during embryonic development and homeostasis in the adult organism. Perturbations of these processes can lead to the development of cancer [ ]. The Eight-Twenty-One (ETO) gene product is able to form complexes w...

[]

0

[ "PFAM" ]

[ "PF08788" ]

[ "NHR2" ]

[ 5154 ]

1

[ "REACTOME" ]

[ "R-HSA-9827857" ]

[ "REACTOME:R-HSA-9827857" ]

1

[ "1wq6", "4jol" ]

2

[ "PUB00017006", "PUB00017256", "PUB00035427" ]

[ "12559562", "11150306", "16616331" ]

[ "The ETO (MTG8) gene family.", "Multiple regions of ETO cooperate in transcriptional repression.", "The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity." ]

[ 2003, 2001, 2006 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 5154 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 61, 4, 23, 12, 17 ]

5

true

Domain

NHR2-like

NHR2

9

IPR014897

14,897

PBCV-specific basic adaptor domain

PBCV_basic_adap

Domain

154

false

The small PBCV-specific basic adaptor protein is found fused to S/T protein kinases and the 2-Cysteine domain [ ].

[]

0

[ "PFAM" ]

[ "PF08789" ]

[ "PBCV_basic_adap" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00035352" ]

[ "16494962" ]

[ "Evolutionary genomics of nucleo-cytoplasmic large DNA viruses." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati", "Viruses", "metagenomes" ]

[ 12, 79, 57, 6 ]

4

[]

0

true

Domain

PBCV-specific basic adaptor domain

PBCV_basic_adap

5

IPR014898

14,898

Zinc finger, C2H2, LYAR-type

Znf_C2H2_LYAR

Domain

3,855

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[]

0

[ "PFAM" ]

[ "PF08790" ]

[ "zf-LYAR" ]

[ 3855 ]

1

[]

0

[ "1wjv", "6zmi", "6zmo" ]

3

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3855 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 2, 5, 3, 6, 1, 6, 4, 1, 1, 4 ]

12

true

Domain

Zinc finger, C2H2, LYAR-type

Znf_C2H2_LYAR

3

IPR014901

14,901

2-cysteine adaptor

2-cysteine_adaptor

Domain

206

false

The virus-specific 2-cysteine adaptor is found fused to OTU/A20-like peptidases and S/T protein kinases. The associations to these proteins indicate that they might function as viral adaptors connecting the kinases and OTU/A20 peptidases to specific targets [ ].

[]

0

[ "PFAM" ]

[ "PF08793" ]

[ "2C_adapt" ]

[ 206 ]

1

[ "EC" ]

[ "2.7.11.1" ]

[ "EC:2.7.11.1" ]

1

[]

0

[ "PUB00035352" ]

[ "16494962" ]

[ "Evolutionary genomics of nucleo-cytoplasmic large DNA viruses." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota", "Megaviricetes", "Pseudomonadota", "metagenomes" ]

[ 6, 165, 3, 32 ]

4

[]

0

true

Domain

2-cysteine adaptor

2-cysteine_adaptor

3

IPR014902

14,902

Factor H binding protein-like, C-terminal

FHBP-like_C

Domain

1,007

false

Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [ ]. The structure of the C-terminal domain consists of an anti-parallel β-barrel overlaid by a short α-helical regio...

[]

0

[ "PFAM" ]

[ "PF08794" ]

[ "FHBP_C" ]

[ 1007 ]

1

[]

0

[ "1ys5", "2kc0", "2kdy", "2w80", "2w81", "2y7s", "2ypv", "3kvd", "4ayd", "4aye", "4ayi", "4aym", "4ayn", "4z3t", "5nqp", "5nqx", "5nqy", "5nqz", "5o14", "5t5f", "6h2y", "6tik", "6xzw", "7ket", "7lcv", "7nru", "7sa6", "7sbz", "8bk2", "8up2" ]

30

[ "PUB00035413", "PUB00065762" ]

[ "16407174", "23133374" ]

[ "Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis.", "Design and evaluation of meningococcal vaccines through structure-based modification of host and pathogen molecules." ]

[ 2006, 2012 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 1007 ]

1

[]

0

true

Domain

Factor H binding protein-like, C-terminal

FHBP-like_C

2

IPR014903

14,903

Protein of unknown function DUF1796

DUF1796

Family

1,635

false

The proteins in this entry are uncharacterised; but are related to papain-like cysteine peptidases.

[]

0

[ "PFAM" ]

[ "PF08795" ]

[ "DUF1796" ]

[ 1635 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Nucleocytoviricota", "metagenomes" ]

[ 1089, 389, 5, 57, 95 ]

5

[]

0

true

Family

Protein of unknown function DUF1796

DUF1796

4

IPR014904

14,904

YkuJ-like

Family

1,359

false

YkuJ is a mixed α/β fold protein consisting of an antiparallel β-sheet with C- and N-terminal helices packed against one side (PDBe: 2ffg) [ ]. The function of YkuJ is not clear.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08796", "PIRSF037356" ]

[ "DUF1797", "DUF1797" ]

[ 1359, 1026 ]

2

[]

0

[ "2ffg" ]

1

[ "PUB00088199" ]

[ "18436958" ]

[ "RDC-assisted modeling of symmetric protein homo-oligomers." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1358, 1 ]

2

[]

0

true

Family

YkuJ-like

9

IPR014905

14,905

HIRAN domain

HIRAN

Domain

9,763

false

The HIRAN domain (HIP116 Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA p...

[ "GO:0003676", "GO:0008270", "GO:0016818" ]

[ "nucleic acid binding", "zinc ion binding", "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM", "SMART" ]

[ "PF08797", "SM00910" ]

[ "HIRAN", "HIRAN" ]

[ 9739, 7822 ]

2

[ "EC", "EC", "METACYC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "3.6.4.-", "PWY-7250", "PWY-7511", "R-HSA-8866654", "R-MMU-8866654" ]

[ "EC:2.3.2.27", "EC:3.6.4.-", "METACYC:PWY-7250", "METACYC:PWY-7511", "REACTOME:R-HSA-8866654", "REACTOME:R-MMU-8866654" ]

6

[ "2mzn", "3k2y", "4s0n", "4xzf", "4xzg", "5bnh", "5k5f", "6kcs", "6l8n", "6l8o" ]

10

[ "PUB00035408" ]

[ "16627993" ]

[ "The HIRAN domain and recruitment of chromatin remodeling and repair activities to damaged DNA." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 39, 2530, 7064, 57, 73 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 31, 9, 7, 6, 3, 11, 7, 1, 1, 33 ]

10

true

Domain

HIRAN domain

HIRAN

1

IPR014906

14,906

Pre-mRNA processing factor 4 (PRP4)-like

PRP4-like

Domain

8,713

false

This small domain is found on PRP4 ribonuleoproteins. PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing [ ]. It is also found in pre-mRNA-splicing factor 18 [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF08799", "SM00500" ]

[ "PRP4", "SFM" ]

[ 8647, 7949 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

5

[ "1mzw", "2dk4", "3jcm", "3jcr", "5gan", "5gap", "5nrl", "5o9z", "5zwm", "5zwo", "6ah0", "6ahd", "6qw6", "6qx9", "8h6e", "8h6j", "8h6k", "8h6l", "8q7n", "8qo9", "8qoz", "8qpa", "8qpb", "8qpe", "8qxd", "8qzs", "8r08", "8r09", "8r0a", "8r0b", "8rm5", "8y6o"...

32

[ "PUB00067984", "PUB00067985" ]

[ "9000057", "528687" ]

[ "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor.", "Plate assay for detection of Leptospira interrogans serovar pomona hemolysin." ]

[ 1997, 1979 ]

2

[]

0

null

[ "Eukaryota" ]

[ 8713 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 3, 2, 9, 5, 3, 13, 6, 1, 2, 26 ]

12

true

Domain

Pre-mRNA processing factor 4 (PRP4)-like

PRP4-like

1

IPR014907

14,907

BT4734-like, N-terminal

BT4734-like_N

Domain

3,034

false

This domain is found mainly in bacteroidetes. In some instances, it is at the N-terminal of , such as in the product of BT4734 , which is incorrectly named Virulence protein E. The function of the domain is unknown.

[]

0

[ "PFAM" ]

[ "PF08800" ]

[ "BT4734-like_N" ]

[ 3034 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Meripilus lineatus", "unclassified sequences" ]

[ 2944, 50, 1, 39 ]

4

[]

0

true

Domain

BT4734-like, N-terminal

BT4734-like_N

9

IPR014910

14,910

Putative monooxygenase YdhR

YdhR

Family

1,993

false

YdhR is a homodimeric protein that comprises of a central four-stranded β sheet and four surrounding α helices [ ]. It shows structural homology to the ActVA-Orf6 and YgiN proteins which indicates it could be a mono-oxygenase.

[]

0

[ "NCBIFAM", "PFAM", "PANTHER" ]

[ "NF008333", "PF08803", "PTHR39169" ]

[ "PRK11118.1", "ydhR", "" ]

[ 1542, 1991, 1683 ]

3

[]

0

[ "1wd6", "2asy", "2hiq" ]

3

[ "PUB00035490" ]

[ "16260765" ]

[ "Solution structure of the Escherichia coli protein ydhR: a putative mono-oxygenase." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 1943, 15, 11, 24 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative monooxygenase YdhR

YdhR

4

IPR014911

14,911

Type 4 secretion system, PilS, N-terminal

PilS_N

Domain

2,039

false

Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator [ ]. Mutagenesis studies suggest that residues on an α-β loop and the C-terminal disulph...

[]

0

[ "PFAM" ]

[ "PF08805" ]

[ "PilS" ]

[ 2039 ]

1

[]

0

[ "1q5f", "3fhu", "3fhv" ]

3

[ "PUB00030128", "PUB00035450" ]

[ "15159389", "14500527" ]

[ "NMR structure of a type IVb pilin from Salmonella typhi and its assembly into pilus.", "The type IVB pili of Salmonella enterica serovar Typhi bind to the cystic fibrosis transmembrane conductance regulator." ]

[ 2004, 2003 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes", "plasmids" ]

[ 10, 2007, 20, 2 ]

4

[]

0

true

Domain

Type 4 secretion system, PilS, N-terminal

PilS_N

8

IPR014912

14,912

Selenoprotein F/M domain

Sep15_SelM_dom

Domain

2,925

false

SelM and Sep15 consists of one catalytic a-domain that assumes a thioredoxin-like fold composed of a mixed four-stranded β-sheet and three interspersed α-helices. The active-site redox motifs of SelM and Sep15 are located between the C terminus of strand beta1 and the N terminus of helix alpha1. SelM and Sep15 may func...

[]

0

[ "PFAM" ]

[ "PF08806" ]

[ "Sep15_SelM" ]

[ 2925 ]

1

[]

0

[ "2a2p", "2a4h" ]

2

[ "PUB00035459" ]

[ "16319061" ]

[ "NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2925 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 2, 4, 6, 4, 3, 2, 5, 5 ]

9

true

Domain

Selenoprotein F/M domain

Sep15_SelM_dom

5

IPR014913

14,913

YppE-like

Family

1,205

false

This family includes the uncharacterised protein YppE, which consists of a four α-helical up-and-down bundle [ ].

[]

0

[ "PFAM" ]

[ "PF08807" ]

[ "DUF1798" ]

[ 1205 ]

1

[]

0

[ "2ets", "2hfi", "2huj", "2im8" ]

4

[ "PUB00047405" ]

[ "18324683" ]

[ "Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold." ]

[ 2008 ]

1

[]

0

null

[ "Bacillati", "marine sediment metagenome" ]

[ 1204, 1 ]

2

[]

0

true

Family

YppE-like

5

IPR014915

14,915

Bacteriophage TLS, TfmB

Phage_TLS_TfmB

Family

1,119

false

This entry is represented by the Bacteriophage TLS, TfmB. The characteristics of the protein distribution suggest prophage matches.

[]

0

[ "PFAM" ]

[ "PF08809" ]

[ "DUF1799" ]

[ 1119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Gibberella intermedia", "Viruses", "metagenomes" ]

[ 854, 1, 255, 9 ]

4

[]

0

true

Family

Bacteriophage TLS, TfmB

Phage_TLS_TfmB

5

IPR014916

14,916

Kinase associated protein B

KapB

Family

1,078

false

Kinase associated protein B (KapB) is one of the major histidine kinases that provide phosphate input in the phosphorelay to produce SpoOA approximately P, the key transcription factor controlling the initiation of sporulation in Bacillus subtilis [ ]. It forms an anti-parallel β sheet with an extending α helical regio...

[]

0

[ "PFAM", "SMART" ]

[ "PF08810", "SM01298" ]

[ "KapB", "KapB" ]

[ 1078, 1075 ]

2

[]

0

[ "1y71" ]

1

[ "PUB00070728" ]

[ "9426145" ]

[ "KapB is a lipoprotein required for KinB signal transduction and activation of the phosphorelay to sporulation in Bacillus subtilis." ]

[ 1997 ]

1

[]

0

null

[ "Bacillales" ]

[ 1078 ]

1

[]

0

true

Family

Kinase associated protein B

KapB

1

IPR014917

14,917

Protein of unknown function DUF1800

DUF1800

Family

8,668

false

This is an entry of large bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF08811" ]

[ "DUF1800" ]

[ 8668 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 7823, 544, 300, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1800

DUF1800

2

IPR014918

14,918

Phage tail tube protein 3

Phage_tail_3

Family

1,328

false

Proteins of this entry include phage tail proteins. They probably include bacterial Ig-like domains related to . Which also includes a number of phage tail invasin proteins.

[]

0

[ "PFAM" ]

[ "PF08813" ]

[ "Phage_tail_3" ]

[ 1328 ]

1

[]

0

[ "9jlf", "9kmh", "9l0f", "9lbn" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 884, 5, 432, 7 ]

4

[]

0

true

Family

Phage tail tube protein 3

Phage_tail_3

9

IPR014919

14,919

XisH protein

XisH

Family

1,685

false

This family contains XisI proteins, also known as FdxN element excision controlling factors, and similar proteins. FdxN element is excised from the chromosome during heterocyst differentiation in cyanobacteria. This is accomplished by the large serine recombinase XisF (fdxN element site-specific recombinase). The xisH ...

[]

0

[ "PFAM", "CDD" ]

[ "PF08814", "cd22366" ]

[ "XisH", "XisH-like" ]

[ 1685, 1333 ]

2

[]

0

[ "2inb", "2okf" ]

2

[ "PUB00035486" ]

[ "9106215" ]

[ "Cell-type specificity of the Anabaena fdxN-element rearrangement requires xisH and xisI." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria" ]

[ 1685 ]

1

[]

0

true

Family

XisH protein

XisH

1

IPR014920

14,920

Nuclear receptor coactivator, Ncoa-type, interlocking

Nuc_rcpt_coact_Ncoa-typ

Domain

4,228

false

This entry represents the interlocking domain of the eukaryotic nuclear receptor coactivators Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target. Nuclear receptors are ligand-activated transcription factors involved in the regulation ...

[ "GO:0003713", "GO:0016922", "GO:0006355", "GO:0005634" ]

[ "transcription coactivator activity", "nuclear receptor binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF08815" ]

[ "Nuc_rec_co-act" ]

[ 4228 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-159418", "R-DRE-3214847", "R-DRE-400206", "R-DRE-5625886", "R-DRE-9707564", "R-HSA-1368108", "R-HSA-159418", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-1989781", "R-HSA-211976", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-3214847", "R-HSA-381340", "R-HSA-3899300", "...

[ "REACTOME:R-DRE-159418", "REACTOME:R-DRE-3214847", "REACTOME:R-DRE-400206", "REACTOME:R-DRE-5625886", "REACTOME:R-DRE-9707564", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-192105", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-193807", "REACTOME:R-HSA-1989781", "REACTOME:R-HS...

63

[ "1kbh", "2c52", "6es5", "6es6", "6es7", "6sqc" ]

6

[ "PUB00029464", "PUB00035991" ]

[ "14757047", "15145939" ]

[ "Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain.", "The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Vertebrata" ]

[ 4228 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 12, 13, 13 ]

4

true

Domain

Nuclear receptor coactivator, Ncoa-type, interlocking

Nuc_rcpt_coact_Ncoa-typ

7

IPR014921

14,921

EsaB

Family

294

false

This group represents an EsaB protein. EsaB seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. It is a negative regulator of EsaC, which is a secretion substrate of the Ess pathway in some Staphylococcus aureus strains [ ]. This entry also includes the uncharac...

[]

0

[ "PIRSF" ]

[ "PIRSF037793" ]

[ "DUF_ubiquitin-like_YukD" ]

[ 294 ]

1

[]

0

[ "2bps" ]

1

[ "PUB00055111" ]

[ "18554323" ]

[ "EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus." ]

[ 2008 ]

1

[ "IPR024962" ]

[]

1

0

1

[ "Bacilli" ]

[ 294 ]

1

[]

0

true

Family

EsaB

8

IPR014922

14,922

YdhG-like domain

YdhG-like

Domain

21,333

false

This α/β domain is found in the Intracellular iron chaperone frataxin from Bacillus subtilis (formerly known as YdhG) [ , ] and the uncharacterised protein YdeI from Bacillus subtilis. Frataxin plays an essential role in iron intracellular trafficking to iron cofactor biogenesis systems including iron-sulfur cluster (F...

[]

0

[ "PFAM" ]

[ "PF08818" ]

[ "DUF1801" ]

[ 21333 ]

1

[]

0

[ "2i8d", "2kl4", "2oc6" ]

3

[ "PUB00061992", "PUB00098100", "PUB00101530", "PUB00101531" ]

[ "17010160", "21744456", "25826316", "27382962" ]

[ "The Rcs phosphorelay system is specific to enteric pathogens/commensals and activates ydeI, a gene important for persistent Salmonella infection of mice.", "The frataxin homologue Fra plays a key role in intracellular iron channeling in Bacillus subtilis.", "Molecular insights into frataxin-mediated iron suppl...

[ 2006, 2011, 2015, 2016 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 81, 20931, 20, 301 ]

4

[]

0

true

Domain

YdhG-like domain

YdhG-like

5

IPR014923

14,923

Protein of unknown function DUF1802

DUF1802

Family

1,355

false

The function of this family is unknown. This region is found associated with a suggesting they could be part of a restriction modification system.

[]

0

[ "PFAM" ]

[ "PF08819" ]

[ "DUF1802" ]

[ 1355 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR008307" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 92, 1183, 57, 23 ]

4

[]

0

true

Family

Protein of unknown function DUF1802

DUF1802

1

IPR014924

14,924

Protein of unknown function DUF1803

DUF1803

Family

707

false

This small domain is found in one or two copies in bacteria. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF08820" ]

[ "DUF1803" ]

[ 707 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanococcus voltae", "bioreactor metagenome" ]

[ 704, 2, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF1803

DUF1803

3

IPR014925

14,925

CGGC domain

CGGC_dom

Domain

1,014

false

This putative domain contains a quite highly conserved sequence of CGGC in its central region. The domain has many conserved cysteines and histidines, suggesting it may have a zinc binding function.

[]

0

[ "PFAM", "SMART" ]

[ "PF08821", "SM01078" ]

[ "CGGC", "CGGC" ]

[ 1014, 996 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 162, 806, 46 ]

3

[]

0

true

Domain

CGGC domain

CGGC_dom

2

IPR014926

14,926

Bacteriophage D3112, Orf24

Phage_D3112_Orf24

Family

652

false

This entry is represented by Bacteriophage D3112, Orf24. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF08822" ]

[ "DUF1804" ]

[ 652 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Glossina brevipalpis", "Viruses", "ecological metagenomes" ]

[ 605, 1, 42, 4 ]

4

[]

0

true

Family

Bacteriophage D3112, Orf24

Phage_D3112_Orf24

9

IPR014927

14,927

Putative peptidoglycan binding

PG-bd_2

Domain

930

false

This entry may be a peptidoglycan binding domain.

[]

0

[ "PFAM" ]

[ "PF08823" ]

[ "PG_binding_2" ]

[ 930 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 165, 756, 9 ]

3

[]

0

true

Domain

Putative peptidoglycan binding

PG-bd_2

8

IPR014928

14,928

Serine rich protein interaction domain

Serine_rich_dom

Domain

4,605

false

This is a serine rich protein that is found in the docking protein p130(cas) (Crk-associated substrate). The protein folds into a four helix bundle which is associated with protein-protein interactions [ ].

[]

0

[ "PFAM" ]

[ "PF08824" ]

[ "Serine_rich" ]

[ 4605 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-186763", "R-HSA-372708", "R-HSA-4420097", "R-HSA-8849471", "R-MMU-186763", "R-MMU-372708", "R-MMU-4420097", "R-MMU-8849471", "R-RNO-186763", "R-RNO-372708", "R-RNO-4420097", "R-RNO-8849471" ]

[ "REACTOME:R-HSA-186763", "REACTOME:R-HSA-372708", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-8849471", "REACTOME:R-MMU-186763", "REACTOME:R-MMU-372708", "REACTOME:R-MMU-4420097", "REACTOME:R-MMU-8849471", "REACTOME:R-RNO-186763", "REACTOME:R-RNO-372708", "REACTOME:R-RNO-4420097", "REACTOME:R-RN...

12

[ "1z23", "2l81" ]

2

[ "PUB00035460" ]

[ "15795225" ]

[ "The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle." ]

[ 2005 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 4605 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 12, 10, 15 ]

5

true

Domain

Serine rich protein interaction domain

Serine_rich_dom

3

IPR014929

14,929

E2 binding

E2-binding

Domain

4,988

false

E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The protein resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with...

[ "GO:0019781", "GO:0045116" ]

[ "NEDD8 activating enzyme activity", "protein neddylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF08825", "SM01181" ]

[ "E2_bind", "E2_bind" ]

[ 4938, 4973 ]

2

[ "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTO...

[ "6.2.1.64", "GenProp1311", "PWY-7899", "R-CEL-8951664", "R-CEL-983168", "R-DDI-8951664", "R-DDI-983168", "R-DME-8951664", "R-DME-983168", "R-DRE-8951664", "R-DRE-983168", "R-HSA-5607761", "R-HSA-5676590", "R-HSA-8951664", "R-HSA-983168", "R-MMU-5607761", "R-MMU-5676590", "R-MMU-895...

[ "EC:6.2.1.64", "GP:GenProp1311", "METACYC:PWY-7899", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-983168", "REACTOME:R-DME-8951664", "REACTOME:R-DME-983168", "REACTOME:R-DRE-8951664", "REACTOME:R-DRE-983168", "REACTOME:R-HSA-5607761", "REACTOME...

25

[ "1r4m", "1r4n", "1tt5", "1y8x", "1yov", "2lq7", "2nvu", "3dbh", "3dbl", "3dbr", "3fn1", "3gzn" ]

12

[ "PUB00032601" ]

[ "15694336" ]

[ "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4988 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 3, 1, 5, 3, 2, 2, 6, 1, 7 ]

11

true

Domain

E2 binding

E2-binding

7

IPR014930

14,930

Myotonic dystrophy protein kinase, coiled coil

Myotonic_dystrophy_kinase_coil

Domain

5,933

false

This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure. It plays a role in dimerisation [ ].

[ "GO:0004674", "GO:0005524", "GO:0006468" ]

[ "protein serine/threonine kinase activity", "ATP binding", "protein phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF08826" ]

[ "DMPK_coil" ]

[ 5933 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-HSA-5578775", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013406", "R-HSA-9013409", "R-MMU-5578775", "R-MMU-9013149", "R-MMU-9013406", "R-RNO-9013149", "R-RNO-9013406" ]

[ "EC:2.7.11.1", "REACTOME:R-HSA-5578775", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013406", "REACTOME:R-HSA-9013409", "REACTOME:R-MMU-5578775", "REACTOME:R-MMU-9013149", "REACTOME:R-MMU-9013406", "REACTOME:R-RNO-9013149", "REACTOME:R-RNO-9013406" ]

11

[ "1wt6", "3cve" ]

2

[ "PUB00035380" ]

[ "12832055" ]

[ "Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Paenibacillus agri", "marine metagenome" ]

[ 5931, 1, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 43, 24, 19, 28 ]

4

true

Domain

Myotonic dystrophy protein kinase, coiled coil

Myotonic_dystrophy_kinase_coil

9

IPR014931

14,931

Protein of unknown function DUF1805

DUF1805

Family

1,495

false

This protein is found in bacteria and archaea and has an N-terminal tetramerisation region that is composed of β sheets.

[]

0

[ "PFAM" ]

[ "PF08827" ]

[ "DUF1805" ]

[ 1495 ]

1

[]

0

[ "1qw2" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 160, 1313, 10, 12 ]

4

[]

0

true

Family

Protein of unknown function DUF1805

DUF1805

1

IPR014932

14,932

Doublesex dimerisation

DSX_dimer

Domain

499

false

Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila. The structure has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF08828", "SM01143" ]

[ "DSX_dimer", "DSX_dimer" ]

[ 496, 492 ]

2

[]

0

[ "1zv1", "2jz0", "2jz1" ]

3

[ "PUB00035383" ]

[ "16049008" ]

[ "Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation." ]

[ 2005 ]

1

[]

0

null

[ "Neoptera" ]

[ 499 ]

1

[ "Drosophila melanogaster" ]

[ 5 ]

1

true

Domain

Doublesex dimerisation

DSX_dimer

1

IPR014933

14,933

Alpha C protein, N-terminal

AlphaC_N

Domain

53

false

The alpha C protein (ACP) is found in Streptococcus and acts as an invasin which plays a role in the internalisation and translocation of the organism across human epithelial surfaces. Group B Streptococcus is the leading cause of diseases including bacterial pneumonia, sepsis and meningitis. The N-terminal of ACP is a...

[]

0

[ "PFAM" ]

[ "PF08829" ]

[ "AlphaC_N" ]

[ 53 ]

1

[]

0

[ "1ywm", "2o0i" ]

2

[ "PUB00032716", "PUB00035356", "PUB00035357" ]

[ "15753100", "12427097", "9371832" ]

[ "Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein.", "The alpha C protein mediates internalization of group B Streptococcus within human cervical epithelial cells.", "Inactivation of the alpha C protein antigen gene, bca, by a novel shuttle/suicide vector results in attenu...

[ 2005, 2002, 1997 ]

3

[]

0

null

[ "Streptococcus" ]

[ 53 ]

1

[]

0

true

Domain

Alpha C protein, N-terminal

AlphaC_N

4

IPR014934

14,934

Protein of unknown function DUF1806

DUF1806

Family

1,500

false

This entry consists of bacterial uncharacterised proteins. The structure of one of the proteins has been solved and it adopts a β barrel-like structure.

[]

0

[ "PFAM" ]

[ "PF08830" ]

[ "DUF1806" ]

[ 1500 ]

1

[]

0

[ "1njh" ]

1

[]

0

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432" ]

[ 1499, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF1806

DUF1806

8

IPR014935

14,935

Nuclear receptor coactivator, receptor-binding domain

SRC/p160_LXXLL

Domain

4,451

false

This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding [ ] and includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1 [ , ].

[]

0

[ "PFAM" ]

[ "PF08832" ]

[ "SRC-1" ]

[ 4451 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-159418", "R-DRE-3214847", "R-DRE-400206", "R-DRE-5625886", "R-DRE-9707564", "R-HSA-1368108", "R-HSA-159418", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-1989781", "R-HSA-211976", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-3214847", "R-HSA-381340", "R-HSA-3899300", "...

[ "REACTOME:R-DRE-159418", "REACTOME:R-DRE-3214847", "REACTOME:R-DRE-400206", "REACTOME:R-DRE-5625886", "REACTOME:R-DRE-9707564", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-192105", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-193807", "REACTOME:R-HSA-1989781", "REACTOME:R-HS...

63

[ "1fm6", "1fm9", "1k4w", "1k74", "1k7l", "1kv6", "1n4h", "1nrl", "1p8d", "1rdt", "1tfc", "1wm0", "1xiu", "2hbh", "2hc4", "2hcd", "2hfp", "2npa", "2o9i", "2prg", "3bej", "3ctb", "3cwd", "3dr1", "3et1", "3et3", "3hvl", "3ipq", "3ips", "3ipu", "3kmg", "3lmp"...

178

[ "PUB00029969", "PUB00069384", "PUB00083149" ]

[ "9744270", "9430642", "9482670" ]

[ "Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.", "The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.", "Nuclear receptor-binding sites of coactivators glucoc...

[ 1998, 1998, 1998 ]

3

[]

0

null

[ "Vertebrata" ]

[ 4451 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 11, 13, 13 ]

4

true

Domain

Nuclear receptor coactivator, receptor-binding domain

SRC/p160_LXXLL

7

IPR014936

14,936

Axin beta-catenin binding

Axin_b-cat-bd

Domain

3,074

false

Proteins in this entry are found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex. It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin [ ].

[]

0

[ "PFAM" ]

[ "PF08833" ]

[ "Axin_b-cat_bind" ]

[ 3074 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-195253", "R-DME-196299", "R-DME-209155", "R-DME-209190", "R-DME-209214", "R-DME-209360", "R-DME-209396", "R-DME-209413", "R-DME-209440", "R-DME-209461", "R-DME-432553", "R-DME-4641257", "R-DME-4641262", "R-DRE-4641257", "R-DRE-4641262", "R-HSA-195253", "R-HSA-196299", "R-HSA...

[ "REACTOME:R-DME-195253", "REACTOME:R-DME-196299", "REACTOME:R-DME-209155", "REACTOME:R-DME-209190", "REACTOME:R-DME-209214", "REACTOME:R-DME-209360", "REACTOME:R-DME-209396", "REACTOME:R-DME-209413", "REACTOME:R-DME-209440", "REACTOME:R-DME-209461", "REACTOME:R-DME-432553", "REACTOME:R-DME-464...

45

[ "1qz7", "8ru3" ]

2

[ "PUB00030459" ]

[ "14600025" ]

[ "Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex." ]

[ 2003 ]

1

[]

0

null

[ "Bilateria" ]

[ 3074 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 8, 9, 8, 10 ]

5

true

Domain

Axin beta-catenin binding

Axin_b-cat-bd

1

IPR014937

14,937

Protein of unknown function DUF1810

DUF1810

Family

3,799

false

This is a family of uncharacterised proteins. The structure of one of the members in this family, Rv1873 from Mycobacterium tuberculosis ( ), has been solved and it adopts a mainly α-helical structure [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08837", "PIRSF008546" ]

[ "DUF1810", "UCP008546" ]

[ 3799, 3124 ]

2

[]

0

[ "2jek" ]

1

[ "PUB00041922" ]

[ "17142896" ]

[ "The molecular structure of Rv1873, a conserved hypothetical protein from Mycobacterium tuberculosis, at 1.38 A resolution." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Imitervirales", "Methanobacteriota", "metagenomes" ]

[ 3535, 202, 2, 34, 26 ]

5

[]

0

true

Family

Protein of unknown function DUF1810

DUF1810

4

IPR014938

14,938

YfhH-like

Family

1,288

false

This entry consists of a group of proteins predominantly found in Firmicutes, including Uncharacterized protein YfhH from Bacillus subtilis and protein GK0453 from Geobacillus kaustophilus. GK0453 shows two small domains: an helix-turn-helix like motif is found in its N-terminal domain while an SH3-like β-barrel like s...

[]

0

[ "PFAM" ]

[ "PF08838" ]

[ "DUF1811" ]

[ 1288 ]

1

[]

0

[ "1sf9", "2yxy" ]

2

[ "PUB00100670" ]

[ "23545635" ]

[ "Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426." ]

[ 2013 ]

1

[]

0

null

[ "Bacilli", "human gut metagenome" ]

[ 1287, 1 ]

2

[]

0

true

Family

YfhH-like

1

IPR014939

14,939

CDT1 Geminin-binding domain-like

CDT1_Gemini-bd-like

Domain

4,086

false

This entry represents the geminin-binding domain of the DNA replication factor CDT1 and related domains whose functions are not known [ ].

[]

0

[ "PFAM", "SMART", "CDD" ]

[ "PF08839", "SM01075", "cd08674" ]

[ "CDT1", "CDT1", "Cdt1_m" ]

[ 3996, 3433, 2569 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-HSA-69205", "R-MMU-68867", "R-MMU-68949", "R-MMU-68962", "R-MMU-69052", "R-SPO-68949", "R-SPO-68962" ]

[ "REACTOME:R-HSA-68867", "REACTOME:R-HSA-68949", "REACTOME:R-HSA-68962", "REACTOME:R-HSA-69052", "REACTOME:R-HSA-69205", "REACTOME:R-MMU-68867", "REACTOME:R-MMU-68949", "REACTOME:R-MMU-68962", "REACTOME:R-MMU-69052", "REACTOME:R-SPO-68949", "REACTOME:R-SPO-68962" ]

11

[ "2wvr", "2zxx", "8rwv", "8s0e", "8s0f" ]

5

[ "PUB00032264" ]

[ "15286659" ]

[ "Structural basis for inhibition of the replication licensing factor Cdt1 by geminin." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4086 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 8, 1, 2, 1, 3, 1, 1, 5, 2, 2, 25 ]

11

true

Domain

CDT1 Geminin-binding domain-like

CDT1_Gemini-bd-like

4

IPR014940

14,940

BAAT/Acyl-CoA thioester hydrolase C-terminal

BAAT_C

Domain

8,085

false

Acyl-CoA thioesterases are a group of enzymes that catalyse the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Bile acid-CoA:amino acid N-acetyltransferase (BAAT) is involved in bile acid metabolis...

[]

0

[ "PFAM" ]

[ "PF08840" ]

[ "BAAT_C" ]

[ 8085 ]

1

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "3.1.2", "3.1.2.2", "GenProp1587", "PWY-1121", "PWY-321", "PWY-5972", "PWY-5996", "PWY-6733", "PWY-7723", "R-HSA-159418", "R-HSA-193368", "R-HSA-390247", "R-HSA-77289", "R-HSA-9033241", "R-HSA-9837999", "R-MMU-159418", "R-MMU-193368", "R-MMU-390247", "R-MMU-77289", "R-MMU-90332...

[ "EC:3.1.2", "EC:3.1.2.2", "GP:GenProp1587", "METACYC:PWY-1121", "METACYC:PWY-321", "METACYC:PWY-5972", "METACYC:PWY-5996", "METACYC:PWY-6733", "METACYC:PWY-7723", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-390247", "REACTOME:R-HSA-77289", "REACTOME:R-HSA-9033241", ...

26

[ "3hlk", "3k2i" ]

2

[ "PUB00055595" ]

[ "12810727" ]

[ "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 91, 2417, 5557, 20 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 38, 15, 17, 25 ]

5

true

Domain

BAAT/Acyl-CoA thioester hydrolase C-terminal

BAAT_C

9

IPR014941

14,941

Fimbrium subunit FimB/Mfa2/Mfa3

FimB/Mfa2/Mfa3

Family

2,645

false

Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins [ ]. Normally, FimA fimbriae are long filaments that are easily detached from c...

[]

0

[ "PFAM" ]

[ "PF08842" ]

[ "Mfa2" ]

[ 2645 ]

1

[]

0

[ "3gf8", "3pay", "4qdg", "5nf4", "5nfi" ]

5

[ "PUB00055567", "PUB00055568", "PUB00080708", "PUB00080709" ]

[ "15972485", "19589838", "20530728", "24118823" ]

[ "Short fimbriae of Porphyromonas gingivalis and their role in coadhesion with Streptococcus gordonii.", "Anchoring and length regulation of Porphyromonas gingivalis Mfa1 fimbriae by the downstream gene product Mfa2.", "FimB regulates FimA fimbriation in Porphyromonas gingivalis.", "Localization and function o...

[ 2005, 2009, 2010, 2013 ]

4

[]

0

null

[ "Bacteria", "Popillia japonica", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 2602, 2, 1, 40 ]

4

[]

0

true

Family

Fimbrium subunit FimB/Mfa2/Mfa3

FimB/Mfa2/Mfa3

3

IPR014942

14,942

Nucleotidyl transferase AbiEii toxin, Type IV TA system

AbiEii

Family

18,067

false

This family was recently identified as belonging to the nucleotidyltransferase superfamily [ ]. AbiEii is the cognate toxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection w...

[]

0

[ "PFAM" ]

[ "PF08843" ]

[ "AbiEii" ]

[ 18067 ]

1

[]

0

[ "4o8s", "4ok0", "5uvd", "6j7n", "6j7o", "6j7p", "6j7q", "6j7r", "6j7s", "6j7t", "6y56", "6y5u", "7c46", "7c48", "8an4", "8an5", "8rr5", "8rr6", "8xhr" ]

19

[ "PUB00066751", "PUB00075538" ]

[ "19833706", "24465005" ]

[ "Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.", "A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism." ]

[ 2009, 2014 ]

2

[]

[ "IPR014513" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 231, 16945, 257, 5, 629 ]

5

[]

0

true

Family

Nucleotidyl transferase AbiEii toxin, Type IV TA system

AbiEii

7

IPR014943

14,943

Protein of unknown function DUF1815

DUF1815

Family

336

false

This entry represents uncharacterised proteins found in bacteria. They contain a β-sheet connected to a α-helix.

[]

0

[ "PFAM" ]

[ "PF08844" ]

[ "DUF1815" ]

[ 336 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 336 ]

1

[]

0

true

Family

Protein of unknown function DUF1815

DUF1815

5

IPR014944

14,944

Toxin SymE-like

Toxin_SymE-like

Domain

4,704

false

SymE (SOS-induced yjiW gene with similarity to MazE) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. Its translation is repressed by the antisense RNA SymR, which acts...

[ "GO:0003723", "GO:0016788", "GO:0016070", "GO:0005737" ]

[ "RNA binding", "hydrolase activity, acting on ester bonds", "RNA metabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF08845" ]

[ "SymE_toxin" ]

[ 4704 ]

1

[ "GP" ]

[ "GenProp1091" ]

[ "GP:GenProp1091" ]

1

[]

0

[ "PUB00053151", "PUB00064452", "PUB00064453" ]

[ "17462020", "17376733", "23131729" ]

[ "An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin.", "RNA antitoxins.", "Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR." ]

[ 2007, 2007, 2012 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "ecological metagenomes" ]

[ 4683, 13, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Toxin SymE-like

Toxin_SymE-like

5

IPR014945

14,945

Protein of unknown function DUF1816

DUF1816

Family

620

false

is associated with the domain suggesting this protein could have a role in phycobilisomes.

[]

0

[ "PFAM" ]

[ "PF08846" ]

[ "DUF1816" ]

[ 620 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Paulinella" ]

[ 615, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF1816

DUF1816

3

IPR014946

14,946

Protein chlororespiratory reduction 6

CRR6

Family

946

false

Chlororespiratory reduction 6 is a factor required for the assembly or stabilisation of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis [ ].

[]

0

[ "NCBIFAM", "PFAM", "PANTHER" ]

[ "NF038024", "PF08847", "PTHR35724" ]

[ "CRR6_slr1097", "Crr6", "" ]

[ 846, 933, 903 ]

3

[]

0

[]

0

[ "PUB00075334" ]

[ "16648216" ]

[ "Chlororespiratory reduction 6 is a novel factor required for accumulation of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 387, 559 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 5 ]

3

true

Family

Protein chlororespiratory reduction 6

CRR6

8

IPR014947

14,947

Protein of unknown function DUF1818

DUF1818

Family

403

false

This entry represents a small family of uncharacterised cyanobacterial proteins.

[]

0

[ "PFAM" ]

[ "PF08848" ]

[ "DUF1818" ]

[ 403 ]

1

[]

0

[ "2it9", "2nvn" ]

2

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 363, 40 ]

2

[]

0

true

Family

Protein of unknown function DUF1818

DUF1818

6

IPR014948

14,948

BrxA

Family

1,802

false

BrxA is part of the phage resistance system BREX (Bacteriophage Exclusion). It shares structural homology with the RNA-binding antitermination protein NusB [ ].

[]

0

[ "PFAM" ]

[ "PF08849" ]

[ "BrxA" ]

[ 1802 ]

1

[]

0

[ "3bhw", "7zge" ]

2

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanobacteriota", "metagenomes" ]

[ 1705, 3, 73, 21 ]

4

[]

0

true

Family

BrxA

9

IPR014949

14,949

Protein of unknown function DUF1820

DUF1820

Family

1,823

false

This protein includes small functionally uncharacterised proteins of around 100 amino acids in length.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08850", "PIRSF028538" ]

[ "DUF1820", "DUF1820" ]

[ 1823, 1373 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1777, 4, 42 ]

3

[]

0

true

Family

Protein of unknown function DUF1820

DUF1820

4

IPR014951

14,951

Protein of unknown function DUF1822

DUF1822

Family

1,311

false

This entry includes cyanobacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF08852" ]

[ "DUF1822" ]

[ 1311 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1311 ]

1

[]

0

true

Family

Protein of unknown function DUF1822

DUF1822

8

IPR014952

14,952

Protein of unknown function DUF1823

DUF1823

Family

440

false

These proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08853" ]

[ "DUF1823" ]

[ 440 ]

1

[]

0

[ "2l1n" ]

1

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 342, 98 ]

2

[]

0

true

Family

Protein of unknown function DUF1823

DUF1823

8

IPR014953

14,953

Protein of unknown function DUF1824

DUF1824

Family

416

false

This uncharacterised group of proteins are principally found in cyanobacteria.

[]

0

[ "PFAM" ]

[ "PF08854" ]

[ "DUF1824" ]

[ 416 ]

1

[]

0

[ "2q22" ]

1

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 325, 91 ]

2

[]

0

true

Family

Protein of unknown function DUF1824

DUF1824

6

IPR014954

14,954

Protein of unknown function DUF1825

DUF1825

Family

603

false

These roteins are uncharacterised and are principally found in cyanobacteria.

[]

0

[ "PFAM" ]

[ "PF08855" ]

[ "DUF1825" ]

[ 603 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes", "Cyanobacteriota", "Eukaryota", "marine metagenome" ]

[ 91, 368, 143, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1825

DUF1825

4

IPR014955

14,955

Protein of unknown function DUF1826

DUF1826

Family

2,374

false

These proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF08856" ]

[ "DUF1826" ]

[ 2374 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2124, 242, 8 ]

3

[]

0

true

Family

Protein of unknown function DUF1826

DUF1826

5