interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR017244 | 17,244 | Ribosomal RNA large subunit methyltransferase K/L | 23SrRNA_methyltr_KL | Family | 5,390 | false | false | This entry represents bacterial Ribosomal RNA large subunit methyltransferase K/L, which specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. The methylation occurs before assembly of 23S rRNA into 50S subunits. | [
"GO:0008990",
"GO:0031167",
"GO:0005737"
] | [
"rRNA (guanine-N2-)-methyltransferase activity",
"rRNA methylation",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PIRSF"
] | [
"MF_01858",
"PIRSF037618"
] | [
"23SrRNA_methyltr_KL",
"RNA_Mtase_bacteria_prd"
] | [
5156,
5384
] | 2 | [
"EC",
"EC"
] | [
"2.1.1.173",
"2.1.1.264"
] | [
"EC:2.1.1.173",
"EC:2.1.1.264"
] | 2 | [
"3v8v",
"3v97"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5357,
5,
28
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ribosomal RNA large subunit methyltransferase K/L | Ribosomal RNA large subunit methyltransferase K/L | 23SrRNA_methyltr_KL | 7 |
IPR017245 | 17,245 | BLOC-1 complex, subunit 3 | BLOC-1_complex_su-3 | Family | 873 | false | false | Lysosomes are membrane-bound organelles found in animals that are involved in degradation of endogenous and exogenous macromolecules [ ]. Lysosome-related organelles occur in specific cell types and fulfil specialised functions e.g. melanosomes which synthesise and store pigments in higher eukaryotes. Lysosome biogenes... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF15753",
"PIRSF037630",
"PTHR31974"
] | [
"BLOC1S3",
"BLOC-1_complex_subunit_3",
""
] | [
869,
221,
771
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-432722",
"R-HSA-432722",
"R-MMU-432722",
"R-SSC-432722"
] | [
"REACTOME:R-BTA-432722",
"REACTOME:R-HSA-432722",
"REACTOME:R-MMU-432722",
"REACTOME:R-SSC-432722"
] | 4 | [] | 0 | [
"PUB00043419",
"PUB00043780",
"PUB00067856"
] | [
"15261680",
"15102850",
"21998198"
] | [
"The building BLOC(k)s of lysosomes and related organelles.",
"Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).",
"The schizophrenia susceptibility factor dysbindin and its associated com... | [
2004,
2004,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Marinomonas posidonica (strain CECT 7376 / NCIMB 14433 / IVIA-Po-181)"
] | [
872,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
2,
1,
2
] | 5 | true | Family | BLOC-1 complex, subunit 3 | BLOC-1 complex, subunit 3 | BLOC-1_complex_su-3 | 6 |
IPR017248 | 17,248 | HS1-associating protein X-1 | HAX-1 | Family | 1,315 | false | false | HS1-associating protein X-1 (HAX-1) promotes cell survival [ ] and is involved in the clathrin-mediated endocytosis pathway [ ]. It has been implicated in severe congenital neutropenia (SCN), neurological disorders and cancer [ ]. The voltage-dependent Kv3.3 potassium channel has been shown to bind to HAX-1 to induce A... | [
"GO:0043066"
] | [
"negative regulation of apoptotic process"
] | [
"biological_process"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037634",
"PTHR14938"
] | [
"HS1-associating_X-1",
""
] | [
584,
1315
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00069439",
"PUB00069440",
"PUB00069442",
"PUB00089983",
"PUB00089984"
] | [
"9058808",
"17545607",
"17187068",
"26997484",
"21391832"
] | [
"HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.",
"HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.",
"HAX1 deficiency causes autosomal... | [
1997,
2007,
2007,
2016,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1315
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
12,
10,
11
] | 5 | true | Family | HS1-associating protein X-1 | HS1-associating protein X-1 | HAX-1 | 8 |
IPR017249 | 17,249 | Activator of apoptosis harakiri | Apoptosis_activator_harakiri | Family | 125 | false | false | Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF15196",
"PIRSF037635",
"PTHR15056"
] | [
"Harakiri",
"BID3",
""
] | [
125,
50,
120
] | 3 | [] | [] | [] | 0 | [
"2l58",
"2l5b",
"6xy4",
"7p0u",
"9lgu",
"9li8",
"9ugp"
] | 7 | [
"PUB00017281",
"PUB00043501",
"PUB00043502",
"PUB00043503",
"PUB00043504",
"PUB00043505"
] | [
"11341280",
"17434443",
"17535852",
"15084651",
"16907856",
"17428807"
] | [
"Apoptosis. Death of a monopoly?",
"Structure of the C-terminal domain of the pro-apoptotic protein Hrk and its interaction with model membranes.",
"Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.",
"Critical role for DP5/Harakiri, a Bc... | [
2001,
2007,
2007,
2004,
2006,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
125
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1
] | 3 | true | Family | Activator of apoptosis harakiri | Activator of apoptosis harakiri | Apoptosis_activator_harakiri | 7 |
IPR017250 | 17,250 | Histone deacetylase complex subunit SAP18 | Hist_deAcase_cplx_SAP18 | Family | 1,067 | false | false | Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors is regulated by enzymes that acetylate and deacetylate histones. The Sin3A-histone deacetylase (HDAC) co-repressor complex consists of multiple proteins and regulates ge... | [
"GO:0003714",
"GO:0045892"
] | [
"transcription corepressor activity",
"negative regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037637"
] | [
"HDAC_SAP18"
] | [
1067
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-3214815",
"R-DME-72163",
"R-HSA-3214815",
"R-HSA-427413",
"R-HSA-72163",
"R-HSA-9679191",
"R-MMU-3214815",
"R-MMU-72163"
] | [
"REACTOME:R-DME-3214815",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-3214815",
"REACTOME:R-HSA-427413",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-9679191",
"REACTOME:R-MMU-3214815",
"REACTOME:R-MMU-72163"
] | 8 | [
"2hde",
"4a6q",
"4a8x",
"4a90"
] | 4 | [
"PUB00012633",
"PUB00041370"
] | [
"9150135",
"17002296"
] | [
"Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.",
"Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly."
] | [
1997,
2006
] | 2 | [
"IPR010516"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1067
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus"
] | [
2,
1,
2,
2,
3,
2,
3
] | 7 | true | Family | Histone deacetylase complex subunit SAP18 | Histone deacetylase complex subunit SAP18 | Hist_deAcase_cplx_SAP18 | 2 |
IPR017251 | 17,251 | Apoptotic protease-activating factor 1 | Apaf-1 | Family | 1,107 | false | false | Apoptotic protease activating factor-1 (Apaf-1) is a component protein of the apoptosome [ ]. During apoptosis, cytochrome c is released from mitochondria to the cytosol and binds Apaf-1. Binding of cytochrome c to Apaf-1 allows the recruitment and activation of caspase-9 within the apoptosome [ ]. | [
"GO:0097190",
"GO:0043293"
] | [
"apoptotic signaling pathway",
"apoptosome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PIRSF"
] | [
"PIRSF037646"
] | [
"Apop_pept_activating-1"
] | [
1107
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp2021",
"R-DRE-111458",
"R-DRE-111459",
"R-DRE-6798695",
"R-DRE-9627069",
"R-HSA-111458",
"R-HSA-111459",
"R-HSA-111463",
"R-HSA-111464",
"R-HSA-6798695",
"R-HSA-6803207",
"R-HSA-8953750",
"R-HSA-9627069",
"R-MMU-111458",
"R-MMU-111459",
"R-MMU-6798695",
"R-MMU-9627069",
"R-... | [
"GP:GenProp2021",
"REACTOME:R-DRE-111458",
"REACTOME:R-DRE-111459",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-9627069",
"REACTOME:R-HSA-111458",
"REACTOME:R-HSA-111459",
"REACTOME:R-HSA-111463",
"REACTOME:R-HSA-111464",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6803207",
"REACTOME:R-HSA-895375... | 21 | [
"3j2t",
"3jbt",
"3sfz",
"3shf",
"5juy",
"5wve"
] | 6 | [
"PUB00043547",
"PUB00072002"
] | [
"18439902",
"24651435"
] | [
"PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.",
"MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis."
] | [
2008,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1107
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
3,
7
] | 4 | true | Family | Apoptotic protease-activating factor 1 | Apoptotic protease-activating factor 1 | Apaf-1 | 9 |
IPR017253 | 17,253 | Transcription factor SRY | SRY | Family | 558 | false | false | This entry represents the testis-determining factor Sry (Sex-determining Region Y). Sry is a transcriptional activator that regulates a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) ... | [
"GO:0003677",
"GO:0003700",
"GO:0030238",
"GO:0005634"
] | [
"DNA binding",
"DNA-binding transcription factor activity",
"male sex determination",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF037653"
] | [
"SRY"
] | [
558
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-3769402",
"R-HSA-3769402",
"R-HSA-9690406",
"R-SSC-3769402"
] | [
"REACTOME:R-CFA-3769402",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-9690406",
"REACTOME:R-SSC-3769402"
] | 4 | [] | 0 | [
"PUB00042789",
"PUB00042790",
"PUB00042791",
"PUB00042792",
"PUB00042793",
"PUB00042794"
] | [
"5297880",
"16504207",
"11535586",
"16106197",
"7789944",
"12793612"
] | [
"The vestibular system. Anatomic considerations.",
"SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.",
"The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through i... | [
1967,
2006,
2001,
2005,
1995,
2003
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
558
] | 1 | [
"Homo sapiens"
] | [
60
] | 1 | true | Family | Transcription factor SRY | Transcription factor SRY | SRY | 5 |
IPR017254 | 17,254 | Lipoprotein, LppL | Lipoprotein_LppL | Family | 379 | false | false | This group represents a lipoprotein, LppL type. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037657"
] | [
"Lipoprotein_LppL"
] | [
379
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonas"
] | [
379
] | 1 | [] | [] | 0 | true | Family | Lipoprotein, LppL | Lipoprotein, LppL | Lipoprotein_LppL | 5 |
IPR017255 | 17,255 | Acetyltransferase, GNAT, predicted | AcTrfase_GNAT_prd | Family | 3,844 | false | false | This group represents a predicted acetyltransferase, GNAT family type. Bacillus subtilis has a putative posttranslational modification system of the acuABC genes. Posttranslational modification is an efficient mechanism for controlling the activity of structural proteins, gene expression regulators and enzymes in respo... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037663"
] | [
"Acetyltransf_GNAT_prd"
] | [
3844
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"1mk4",
"8a9n",
"8a9o"
] | 3 | [
"PUB00043437",
"PUB00043438"
] | [
"16855235",
"18487328"
] | [
"Control of acetyl-coenzyme A synthetase (AcsA) activity by acetylation/deacetylation without NAD(+) involvement in Bacillus subtilis.",
"Biochemical and mutational analyses of AcuA, the acetyltransferase enzyme that controls the activity of the acetyl coenzyme a synthetase (AcsA) in Bacillus subtilis."
] | [
2006,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Klosneuvirinae",
"metagenomes"
] | [
204,
3615,
6,
2,
17
] | 5 | [] | [] | 0 | true | Family | Acetyltransferase, GNAT, predicted | Acetyltransferase, GNAT, predicted | AcTrfase_GNAT_prd | 2 |
IPR017256 | 17,256 | Methane monooxygenase component D | MmoD | Family | 50 | false | false | Biological oxidation of methane to methanol by aerobic bacteria is catalysed by two different enzymes, the soluble methane monooxygenase (sMMO) and the membrane-bound or particulate methane monooxygenase (pMMO). This entry represents MmoD, a component and a regulator of the sMMO [ , ]. sMMO is only expressed at very lo... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"NCBIFAM"
] | [
"PF27775",
"PIRSF037664",
"TIGR04550"
] | [
"MmoD",
"Methane_mOase_D",
"sMetMonox_MmoD"
] | [
50,
10,
44
] | 3 | [] | [] | [] | 0 | [
"6d7k"
] | 1 | [
"PUB00032461",
"PUB00074188",
"PUB00074189"
] | [
"15610020",
"11709550",
"23682956"
] | [
"Preparation and X-ray structures of metal-free, dicobalt and dimanganese forms of soluble methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath).",
"Why OrfY? Characterization of MMOD, a long overlooked component of the soluble methane monooxygenase from Methylococcus capsulatus (Bath).",
"Meth... | [
2004,
2002,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
50
] | 1 | [] | [] | 0 | true | Family | Methane monooxygenase component D | Methane monooxygenase component D | MmoD | 6 |
IPR017257 | 17,257 | Spore germination protein GerPD, predicted | Spore_germination_GerPD_prd | Family | 196 | false | false | This entry represents a predicted spore germination protein GerPD. They are required for the formation of functionally normal spores. They could be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [ ]. Members are mainly found in B... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037666"
] | [
"GerPD_prd"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044278"
] | [
"10715007"
] | [
"Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores."
] | [
2000
] | 1 | [
"IPR060762"
] | [] | 1 | 0 | 1 | [
"Bacillales"
] | [
196
] | 1 | [] | [] | 0 | true | Family | Spore germination protein GerPD, predicted | Spore germination protein GerPD, predicted | Spore_germination_GerPD_prd | 6 |
IPR017258 | 17,258 | Chloroquine resistance transporter | Transprt_Chloroquine | Family | 141 | false | false | This family consists of the chloroquine resistance transporter (CRT) from apicomplexan parasites, including the malaria parasite Plasmodium falciparum, and homologues from Dictyostelium discoideum [ ]. Mutations in this transporter are responsible for resistance to the antimalarial drug chloroquine [ , , ]. | [
"GO:0042910",
"GO:0042908"
] | [
"xenobiotic transmembrane transporter activity",
"xenobiotic transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037671"
] | [
"Transprt_Chloroquine_res"
] | [
141
] | 1 | [] | [] | [] | 0 | [
"6ukj"
] | 1 | [
"PUB00073577",
"PUB00073578",
"PUB00073579",
"PUB00073581"
] | [
"15258157",
"15883156",
"11343215",
"19779197"
] | [
"Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT.",
"Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum tra... | [
2004,
2005,
2001,
2009
] | 4 | [
"IPR013936"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
141
] | 1 | [] | [] | 0 | true | Family | Chloroquine resistance transporter | Chloroquine resistance transporter | Transprt_Chloroquine | 7 |
IPR017259 | 17,259 | Uncharacterised conserved protein UCP037672 | UCP037672 | Family | 2,215 | false | false | This group represents a uncharacterised conserved proteins from enterobacteriaceae. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF12650",
"PIRSF037672"
] | [
"DUF3784",
"UCP037672"
] | [
2215,
112
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
99,
2108,
8
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP037672 | Uncharacterised conserved protein UCP037672 | UCP037672 | 5 |
IPR017260 | 17,260 | Uncharacterised conserved protein UCP037673/Ycf91 | UCP037673/Ycf91 | Family | 384 | false | false | This entry represents a group of uncharacterised conserved proteins, including the uncharacterised protein Ycf91 from Pyropia yezoensis (Red algae) and Ycf91-like protein from Nostoc sp. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037673"
] | [
"UCP037673"
] | [
384
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
372,
12
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP037673/Ycf91 | Uncharacterised conserved protein UCP037673/Ycf91 | UCP037673/Ycf91 | 7 |
IPR017261 | 17,261 | DNA mismatch repair protein MutS/MSH | DNA_mismatch_repair_MutS/MSH | Family | 31,184 | false | false | This family of DNA mismatch repair proteins includes MutS and Msh. Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of t... | [
"GO:0030983",
"GO:0006298"
] | [
"mismatched DNA binding",
"mismatch repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037677"
] | [
"DNA_mis_repair_Msh6"
] | [
31184
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-5358565",
"R-DDI-5358606",
"R-DME-5358565",
"R-HSA-5358565",
"R-HSA-5632928",
"R-HSA-5632968",
"R-MMU-5358565",
"R-MMU-5358606",
"R-SCE-5358565",
"R-SCE-5358606",
"R-SPO-5358565",
"R-SPO-5358606"
] | [
"REACTOME:R-DDI-5358565",
"REACTOME:R-DDI-5358606",
"REACTOME:R-DME-5358565",
"REACTOME:R-HSA-5358565",
"REACTOME:R-HSA-5632928",
"REACTOME:R-HSA-5632968",
"REACTOME:R-MMU-5358565",
"REACTOME:R-MMU-5358606",
"REACTOME:R-SCE-5358565",
"REACTOME:R-SCE-5358606",
"REACTOME:R-SPO-5358565",
"REACTOM... | 12 | [
"1e3m",
"1ewq",
"1ewr",
"1fw6",
"1ng9",
"1nne",
"1oh5",
"1oh6",
"1oh7",
"1oh8",
"1w7a",
"1wb9",
"1wbb",
"1wbd",
"2o8b",
"2o8c",
"2o8d",
"2o8e",
"2o8f",
"2wtu",
"3k0s",
"3thw",
"3thx",
"3thy",
"3thz",
"3zlj",
"5akb",
"5akc",
"5akd",
"5x9w",
"5yk4",
"6i5f"... | 50 | [
"PUB00004486",
"PUB00010188",
"PUB00024413",
"PUB00042218",
"PUB00042612",
"PUB00042613",
"PUB00042614",
"PUB00042615"
] | [
"9722651",
"8036718",
"11048711",
"17426027",
"17919654",
"17599803",
"17951114",
"17965091"
] | [
"A phylogenomic study of the MutS family of proteins.",
"Colon cancer and DNA repair: have mismatches met their match?",
"The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.",
"Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramer... | [
1998,
1994,
2000,
2007,
2007,
2007,
2008,
2007
] | 8 | [
"IPR045076"
] | [
"IPR005748"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
795,
20017,
9945,
57,
370
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
13,
1,
14,
1,
1,
8,
7,
2,
8,
4,
3,
3,
22
] | 13 | true | Family | DNA mismatch repair protein MutS/MSH | DNA mismatch repair protein MutS/MSH | DNA_mismatch_repair_MutS/MSH | 7 |
IPR017262 | 17,262 | Aegyptin-like | Aegyptin-like | Family | 18 | false | false | This entry represents a group of proteins from mosquitoes, including Aegyptin from Aedes aegypti (Yellowfever mosquito) and Aegyptin-like protein (AAPP) from Anopheles stephensi (Indo-Pakistan malaria mosquito). Both proteins modulate blood feeding of female mosquitoes on vertebrate hosts [ , , ]. Aegyptin, also known ... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037682"
] | [
"Salivary_gland_allergen_Aed3"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042743",
"PUB00154488",
"PUB00155418",
"PUB00155419",
"PUB00155420",
"PUB00155421",
"PUB00155422"
] | [
"12213246",
"24778255",
"18056842",
"21986215",
"22738392",
"25173089",
"30816309"
] | [
"Toward a description of the sialome of the adult female mosquito Aedes aegypti.",
"Collagen-binding protein, Aegyptin, regulates probing time and blood feeding success in the dengue vector mosquito, Aedes aegypti.",
"Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a sali... | [
2002,
2014,
2008,
2012,
2013,
2014,
2019
] | 7 | [] | [] | 0 | 0 | null | [
"Culicidae"
] | [
18
] | 1 | [] | [] | 0 | true | Family | Aegyptin-like | Aegyptin-like | Aegyptin-like | 2 |
IPR017263 | 17,263 | Uncharacterised conserved protein UCP037692 | UCP037692 | Family | 516 | false | false | This group represents a uncharacterised conserved proteins from enterobacteriaceae. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF17277",
"PIRSF037692"
] | [
"DUF5342",
"UCP037692"
] | [
516,
425
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacilli"
] | [
516
] | 1 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP037692 | Uncharacterised conserved protein UCP037692 | UCP037692 | 3 |
IPR017264 | 17,264 | Small ribosomal subunit protein mS37, fungal-type | Ribosomal_mS37_fun | Family | 1,748 | false | false | This group represents a the small ribosomal subunit protein mS37, also known as mitochondrial ribosomal protein 10, which is involved in mitochondrial genome encoded proteins translation [ ]. | [
"GO:0003735",
"GO:0032543"
] | [
"structural constituent of ribosome",
"mitochondrial translation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037706",
"PTHR28066"
] | [
"MRP10",
""
] | [
777,
1748
] | 2 | [] | [] | [] | 0 | [
"5mrc",
"5mre",
"5mrf",
"6xyw",
"6yw5",
"6ywe",
"6ywx",
"6ywy",
"8d8k",
"8d8l",
"8om2",
"8om3",
"8om4",
"9evs",
"9gyt"
] | 15 | [
"PUB00010187"
] | [
"9065385"
] | [
"Cloning and characterization of MRP10, a yeast gene coding for a mitochondrial ribosomal protein."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1748
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
1,
4,
1,
1,
2
] | 6 | true | Family | Small ribosomal subunit protein mS37, fungal-type | Small ribosomal subunit protein mS37, fungal-type | Ribosomal_mS37_fun | 1 |
IPR017265 | 17,265 | rRNA-processing protein Fyv7, fungi | Fyv7_fungi | Family | 47 | false | false | This entry represents Fyv7 (Function required for yeast viability protein 7) from fungi. These proteins are involved in the processing of 20S pre-rRNA during the maturation of SSU-rRNA from tricistronic RNA transcripts (SSU-rRNA, 5.8S rRNA, LSU-rRNA). The SSU (small subunit) processome is required for production of the... | [
"GO:0006364",
"GO:0005730"
] | [
"rRNA processing",
"nucleolus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PIRSF"
] | [
"PIRSF037708"
] | [
"rRNA_proc_FYV7"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042733"
] | [
"12242301"
] | [
"Components of an interdependent unit within the SSU processome regulate and mediate its activity."
] | [
2002
] | 1 | [
"IPR013730"
] | [] | 1 | 0 | 1 | [
"Ascomycota"
] | [
47
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | rRNA-processing protein Fyv7, fungi | rRNA-processing protein Fyv7, fungi | Fyv7_fungi | 4 |
IPR017266 | 17,266 | Cyclin-dependent kinase 2-associated protein 1/2 | DOC_1/2 | Family | 2,563 | false | false | This group represents the cyclin-dependent kinase 2-associated protein 1/2 (DOC-1/1R). DOC-1 is a specific inhibitor of the cell-cycle kinase CDK2 [ ]. DOC-1R associates with CDK2 and inhibits CDK2 activation by obstructing its association with cyclin E and A [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF09806",
"PIRSF037709",
"PTHR22607"
] | [
"CDK2AP",
"CDK2-associated_p2",
""
] | [
2520,
694,
2453
] | 3 | [] | [] | [] | 0 | [
"2kw6",
"2m1l"
] | 2 | [
"PUB00083311",
"PUB00083312"
] | [
"10938106",
"23781148"
] | [
"p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein.",
"Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation."
] | [
2000,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa",
"bird metagenome"
] | [
2562,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
6,
5,
5,
11
] | 6 | true | Family | Cyclin-dependent kinase 2-associated protein 1/2 | Cyclin-dependent kinase 2-associated protein 1/2 | DOC_1/2 | 7 |
IPR017267 | 17,267 | Cytochrome c oxidase subunit VIIa-related, mitochondrial | Cyt_c_oxidase_su7a-rel_mt | Family | 673 | false | false | This group represents a cytochrome c oxidase subunit VIIa-related protein, mitochondrial type (also known as Cytochrome c oxidase subunit 7A2-like, mitochondrial) [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037710"
] | [
"COX7A-rel_mt"
] | [
673
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5628897",
"R-BTA-611105",
"R-BTA-9707564",
"R-BTA-9864848",
"R-DRE-5628897",
"R-DRE-611105",
"R-DRE-9707564",
"R-HSA-5628897",
"R-HSA-611105",
"R-HSA-9707564",
"R-HSA-9864848",
"R-MMU-5628897",
"R-MMU-611105",
"R-MMU-9707564",
"R-MMU-9864848"
] | [
"REACTOME:R-BTA-5628897",
"REACTOME:R-BTA-611105",
"REACTOME:R-BTA-9707564",
"REACTOME:R-BTA-9864848",
"REACTOME:R-DRE-5628897",
"REACTOME:R-DRE-611105",
"REACTOME:R-DRE-9707564",
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9707564",
"REACTOME:R-HSA-9864848",
"REACTOME:R... | 15 | [
"7o37",
"7o3c",
"7o3e",
"8pw5"
] | 4 | [
"PUB00155426"
] | [
"27545886"
] | [
"COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation."
] | [
2016
] | 1 | [
"IPR003177"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
673
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
5,
5
] | 4 | true | Family | Cytochrome c oxidase subunit VIIa-related, mitochondrial | Cytochrome c oxidase subunit VIIa-related, mitochondrial | Cyt_c_oxidase_su7a-rel_mt | 7 |
IPR017268 | 17,268 | Tax1-binding protein 3 | Tax1-binding_p3 | Family | 585 | false | false | This entry represents Tax1-binding protein 3, also known as TIP-1, which is a PDZ domain-containing protein that functions in a wide variety of biological events through selective interaction with different proteins. It interacts with the RhoA effector protein rhotekin [ ]. It also associates with glutaminase L [ ], po... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037712"
] | [
"Tax1-binding_p3"
] | [
585
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5666185",
"R-HSA-5666185",
"R-MMU-5666185"
] | [
"REACTOME:R-CEL-5666185",
"REACTOME:R-HSA-5666185",
"REACTOME:R-MMU-5666185"
] | 3 | [
"2kg2",
"2l4s",
"2l4t",
"3diw",
"3dj1",
"3dj3",
"3gj9",
"4nnm"
] | 8 | [
"PUB00036134",
"PUB00057228",
"PUB00057229",
"PUB00088070",
"PUB00088071",
"PUB00088072",
"PUB00088073"
] | [
"12874278",
"10940294",
"21139582",
"11163757",
"16855024",
"17855605",
"22564736"
] | [
"The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.",
"The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.",
"The HPV16 E6 binding protein Tip-1 interacts with ... | [
2003,
2000,
2011,
2001,
2006,
2007,
2012
] | 7 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
585
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
1,
1,
2
] | 6 | true | Family | Tax1-binding protein 3 | Tax1-binding protein 3 | Tax1-binding_p3 | 7 |
IPR017269 | 17,269 | Biopolymer transport ExbB-like protein 1 | Biopolymer_transpt_ExbB-like_1 | Family | 130 | false | false | This group represents the biopolymer transport exbB-like protein 1. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037713"
] | [
"Biopolymer_transpt_exbB-like"
] | [
130
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Campylobacterales"
] | [
130
] | 1 | [] | [] | 0 | true | Family | Biopolymer transport ExbB-like protein 1 | Biopolymer transport ExbB-like protein 1 | Biopolymer_transpt_ExbB-like_1 | 5 |
IPR017270 | 17,270 | Putative MotA/TolQ/ExbB family protein | MotA/TolQ/ExbB-rel | Family | 2,139 | false | false | This entry represents uncharacterised proteins related to TolQ and other members of the MotA/TolQ/ExbB family. TolQ and TolR have structural and functional homologies not only to ExbB and ExbD of the TonB system, but also with MotA and MotB of the flagellar motor. These three systems are thought to function as ion pote... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037714"
] | [
"TolR"
] | [
2139
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078049",
"PUB00078050"
] | [
"11722743",
"21285349"
] | [
"The TolQ-TolR proteins energize TolA and share homologies with the flagellar motor proteins MotA-MotB.",
"Mapping the interactions between Escherichia coli TolQ transmembrane segments."
] | [
2001,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Hemiselmis tepida",
"ecological metagenomes"
] | [
2107,
1,
31
] | 3 | [] | [] | 0 | true | Family | Putative MotA/TolQ/ExbB family protein | Putative MotA/TolQ/ExbB family protein | MotA/TolQ/ExbB-rel | 7 |
IPR017271 | 17,271 | Transcription regulator HTH, MJ1545 | MJ1545 | Family | 713 | false | false | This group represents a predicted HTH transcriptional regulator MJ1545, AF_2414 and similar proteins in archaea. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037724"
] | [
"TF_HTH_MJ1545_prd"
] | [
713
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"unclassified sequences"
] | [
708,
5
] | 2 | [] | [] | 0 | true | Family | Transcription regulator HTH, MJ1545 | Transcription regulator HTH, MJ1545 | MJ1545 | 4 |
IPR017273 | 17,273 | Probable cell wall amidase LytH | LytH | Family | 155 | false | false | This group represents a predicted cell-wall amidase, LytH type. LytH (YunA) has been identified as a sporulation-specific part of the cortex structure. The lytH gene is only expressed during sporulation and is controlled by the mother cell-specific sigma factor sigma(K). lytH encodes an L-Ala-D-Glu peptidase involved i... | [
"GO:0016811",
"GO:0071555",
"GO:0005576"
] | [
"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides",
"cell wall organization",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF037730"
] | [
"CWA_LytH_prd"
] | [
155
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.5.1.-",
"PWY-1822",
"PWY-5497",
"PWY-5784",
"PWY-5846",
"PWY-6409",
"PWY-6899",
"PWY-7018",
"PWY-7403",
"PWY-7430",
"PWY-7496",
"PWY-7571",
"PWY-7652",
"PWY-7771",
"PWY-7821",
"PWY-7850",
"PWY-8229",
"PWY-8293",
"PWY-8402",
"PWY-8418",
"PWY-8431",
"PWY-8432",
"PWY-8453... | [
"EC:3.5.1.-",
"METACYC:PWY-1822",
"METACYC:PWY-5497",
"METACYC:PWY-5784",
"METACYC:PWY-5846",
"METACYC:PWY-6409",
"METACYC:PWY-6899",
"METACYC:PWY-7018",
"METACYC:PWY-7403",
"METACYC:PWY-7430",
"METACYC:PWY-7496",
"METACYC:PWY-7571",
"METACYC:PWY-7652",
"METACYC:PWY-7771",
"METACYC:PWY-7... | 23 | [] | 0 | [
"PUB00044107",
"PUB00044108"
] | [
"12813075",
"18070966"
] | [
"Characterization of LytH, a differentiation-associated peptidoglycan hydrolase of Bacillus subtilis involved in endospore cortex maturation.",
"Staphylococcus aureus clinical isolate with high-level methicillin resistance with an lytH mutation caused by IS1182 insertion."
] | [
2003,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Bacilli"
] | [
155
] | 1 | [] | [] | 0 | true | Family | Probable cell wall amidase LytH | Probable cell wall amidase LytH | LytH | 9 |
IPR017274 | 17,274 | Putative N-acetyltransferase YlbP | YlbP | Family | 930 | false | false | This group represents a predicted N-acetyltransferase, YlbP type. | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM",
"PIRSF"
] | [
"MF_00824",
"NF010241",
"PIRSF037732"
] | [
"Acetyltransf_YlbP",
"PRK13688.1",
"YlbP_prd"
] | [
843,
915,
928
] | 3 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"2pr1"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
930
] | 1 | [] | [] | 0 | true | Family | Putative N-acetyltransferase YlbP | Putative N-acetyltransferase YlbP | YlbP | 1 |
IPR017275 | 17,275 | Transcription factor FapR | Transcription_factor_FapR | Family | 2,082 | false | false | This entry represents the transcription factor FapR, which is involved in the regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism [ ]. FapR controls the expression of many genes involved in fatty acid and phospholipid metabolism (the fap regulon) [ ]. | [
"GO:0003700",
"GO:0045717",
"GO:0045892"
] | [
"DNA-binding transcription factor activity",
"negative regulation of fatty acid biosynthetic process",
"negative regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM",
"PIRSF"
] | [
"MF_01814",
"NF003359",
"PIRSF037733"
] | [
"Transcrip_fact_FapR",
"PRK04424.1",
"Transcription_factor_FapR"
] | [
1383,
2082,
1990
] | 3 | [] | [] | [] | 0 | [
"2f3x",
"4a0x",
"4a0y",
"4a0z",
"4a12"
] | 5 | [
"PUB00042916",
"PUB00042917"
] | [
"17919287",
"12737802"
] | [
"Regulation of fatty acid metabolism in bacteria.",
"FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis."
] | [
2007,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2073,
9
] | 2 | [] | [] | 0 | true | Family | Transcription factor FapR | Transcription factor FapR | Transcription_factor_FapR | 9 |
IPR017276 | 17,276 | Synthesis of cytochrome c oxidase, Sco1/Sco2 | Synth_of_cyt-c-oxidase_Sco1/2 | Family | 2,238 | false | false | This entry represents cytochrome c oxidase assembly factors Sco1 and Sco2 (Synthesis of Cytochrome c Oxidase, factors 1 and 2), mitochondrial inner membrane-tethered metallochaperones that have regulatory roles in the maintenance of cellular copper homeostasis. These proteins are essential for the assembly of the catal... | [
"GO:0005507",
"GO:0016531",
"GO:0006878",
"GO:0008535",
"GO:0005743"
] | [
"copper ion binding",
"copper chaperone activity",
"intracellular copper ion homeostasis",
"respiratory chain complex IV assembly",
"mitochondrial inner membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PIRSF"
] | [
"PIRSF037736"
] | [
"SCO1"
] | [
2238
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9864848",
"R-DRE-9864848",
"R-HSA-5628897",
"R-HSA-9864848",
"R-MMU-9864848"
] | [
"REACTOME:R-BTA-9864848",
"REACTOME:R-DRE-9864848",
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-9864848"
] | 5 | [] | 0 | [
"PUB00032292",
"PUB00042747",
"PUB00042748",
"PUB00042749"
] | [
"15659396",
"17189203",
"17850752",
"16728594"
] | [
"Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase \"assembly\" protein.",
"The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis.",
"A structural characterization of human SCO... | [
2005,
2007,
2007,
2006
] | 4 | [
"IPR003782"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2238
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
1,
1,
2,
3,
1,
2,
2,
1
] | 9 | true | Family | Synthesis of cytochrome c oxidase, Sco1/Sco2 | Synthesis of cytochrome c oxidase, Sco1/Sco2 | Synth_of_cyt-c-oxidase_Sco1/2 | 3 |
IPR017278 | 17,278 | TIR domain-containing adapter molecule 1 | TICAM1 | Family | 12 | false | false | TIR domain-containing adapter molecule 1 (TICAM1) is involved in innate immunity against invading pathogens. It is an adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis [ , ]. | [
"GO:0045087"
] | [
"innate immune response"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF037744"
] | [
"TIR_Ticam"
] | [
12
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-140534",
"R-HSA-166166",
"R-HSA-168164",
"R-HSA-168927",
"R-HSA-1810476",
"R-HSA-2562578",
"R-HSA-5602566",
"R-HSA-5602571",
"R-HSA-9013957",
"R-HSA-9013973",
"R-HSA-9014325",
"R-HSA-936964",
"R-HSA-937041",
"R-HSA-937072",
"R-HSA-975163",
"R-HSA-9824878",
"R-HSA-9828211",
"... | [
"REACTOME:R-HSA-140534",
"REACTOME:R-HSA-166166",
"REACTOME:R-HSA-168164",
"REACTOME:R-HSA-168927",
"REACTOME:R-HSA-1810476",
"REACTOME:R-HSA-2562578",
"REACTOME:R-HSA-5602566",
"REACTOME:R-HSA-5602571",
"REACTOME:R-HSA-9013957",
"REACTOME:R-HSA-9013973",
"REACTOME:R-HSA-9014325",
"REACTOME:R-... | 25 | [
"8rlm"
] | 1 | [
"PUB00068020",
"PUB00068021"
] | [
"12471095",
"12539043"
] | [
"Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.",
"TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction."
] | [
2002,
2003
] | 2 | [
"IPR046946"
] | [] | 1 | 0 | 1 | [
"Boreoeutheria"
] | [
12
] | 1 | [
"Homo sapiens",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | TIR domain-containing adapter molecule 1 | TIR domain-containing adapter molecule 1 | TICAM1 | 6 |
IPR017279 | 17,279 | Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap | Tol-interleuk_rcpt_adapt_Tirap | Family | 985 | false | false | This group represents a toll-interleukin 1 receptor domain-containing adaptor protein, Tirap type. | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037750",
"PTHR22662"
] | [
"TIR_Tirap",
""
] | [
225,
985
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1236974",
"R-HSA-166058",
"R-HSA-5602498",
"R-HSA-5603041",
"R-MMU-166058"
] | [
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-166058",
"REACTOME:R-HSA-5602498",
"REACTOME:R-HSA-5603041",
"REACTOME:R-MMU-166058"
] | 5 | [
"2ndh",
"2y92",
"3ub2",
"3ub3",
"3ub4",
"4fz5",
"4lqd",
"5uzb",
"8jzm",
"9fqm"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bilateria",
"Methanosarcina mazei"
] | [
8,
976,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
6,
3
] | 4 | true | Family | Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap | Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap | Tol-interleuk_rcpt_adapt_Tirap | 3 |
IPR017281 | 17,281 | Myeloid differentiation primary response protein MyD88 | Myelin_different_resp_MyD88 | Family | 1,953 | false | false | Myeloid differentiation primary response protein MyD88 is an intracellular adaptor protein that has an essential role in innate immune signalling. It is vital for the proper responses of interleukin-1 and interleukin-18 and nearly all toll-like receptors (except TLR3) in the activation of transcription factors NF-kappa... | [
"GO:0070976",
"GO:0002755",
"GO:0043123"
] | [
"TIR domain binding",
"MyD88-dependent toll-like receptor signaling pathway",
"positive regulation of canonical NF-kappaB signal transduction"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037756",
"PTHR15079"
] | [
"MyD88",
""
] | [
862,
1953
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-209543",
"R-GGA-209543",
"R-GGA-3134963",
"R-GGA-433822",
"R-GGA-451477",
"R-GGA-451514",
"R-GGA-573298",
"R-GGA-9020702",
"R-GGA-977240",
"R-HSA-1236974",
"R-HSA-1257604",
"R-HSA-166058",
"R-HSA-1810476",
"R-HSA-209543",
"R-HSA-3134963",
"R-HSA-5602498",
"R-HSA-5602680",
"R... | [
"REACTOME:R-DRE-209543",
"REACTOME:R-GGA-209543",
"REACTOME:R-GGA-3134963",
"REACTOME:R-GGA-433822",
"REACTOME:R-GGA-451477",
"REACTOME:R-GGA-451514",
"REACTOME:R-GGA-573298",
"REACTOME:R-GGA-9020702",
"REACTOME:R-GGA-977240",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-1257604",
"REACTOME:R-HSA... | 40 | [
"2js7",
"2z5v",
"3mop",
"4dom",
"4eo7",
"6i3n",
"7beq",
"7ber",
"7l6w",
"8s78",
"8w8m",
"8yym"
] | 12 | [
"PUB00063576",
"PUB00063581",
"PUB00063582",
"PUB00063583"
] | [
"22996173",
"14993454",
"11960013",
"18669862"
] | [
"The essential adaptors of innate immune signaling.",
"TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.",
"IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.",
"Pyogenic bacterial infections in humans with MyD88 defi... | [
2012,
2003,
2002,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1953
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
12,
9,
5
] | 5 | true | Family | Myeloid differentiation primary response protein MyD88 | Myeloid differentiation primary response protein MyD88 | Myelin_different_resp_MyD88 | 8 |
IPR017282 | 17,282 | Histone deposition protein Asf1 | Hist_deposition_Asf1 | Family | 1,352 | false | false | Asf1 is a histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly [ , ]. | [
"GO:0042393",
"GO:0006334",
"GO:0006337",
"GO:0005634"
] | [
"histone binding",
"nucleosome assembly",
"nucleosome disassembly",
"nucleus"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF037759"
] | [
"Histone_Asf1"
] | [
1352
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-CEL-2559584",
"R-SCE-2559584"
] | [
"REACTOME:R-CEL-2559584",
"REACTOME:R-SCE-2559584"
] | 2 | [
"6o22",
"7unk",
"8ghm",
"8ghn"
] | 4 | [
"PUB00078067",
"PUB00078068"
] | [
"26243657",
"25618846"
] | [
"MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork.",
"Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork."
] | [
2015,
2015
] | 2 | [
"IPR006818"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1352
] | 1 | [
"Caenorhabditis elegans",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1,
1
] | 4 | true | Family | Histone deposition protein Asf1 | Histone deposition protein Asf1 | Hist_deposition_Asf1 | 5 |
IPR017283 | 17,283 | Protein/nucleic acid deglycase HchA | HchA | Family | 1,226 | false | false | Escherichia coli Hsp31, the hchA gene product, has been reported to function as a chaperone that plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells [ , , , ]. It has also been reported to function as a glutathione-independent glyoxa... | [
"GO:0036524"
] | [
"protein deglycase activity"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM",
"PIRSF"
] | [
"MF_01046",
"NF003168",
"PIRSF037798"
] | [
"Deglycase_HchA",
"PRK04155.1",
"Chaperone_HchA"
] | [
150,
1215,
1179
] | 3 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METAC... | [
"3.1.2.-",
"3.5.1.-",
"3.5.1.124",
"PWY-1822",
"PWY-3602",
"PWY-5109",
"PWY-5497",
"PWY-5784",
"PWY-5846",
"PWY-6322",
"PWY-6409",
"PWY-6585",
"PWY-6899",
"PWY-6917",
"PWY-6948",
"PWY-6995",
"PWY-6997",
"PWY-7007",
"PWY-7018",
"PWY-7216",
"PWY-7292",
"PWY-7401",
"PWY-7402... | [
"EC:3.1.2.-",
"EC:3.5.1.-",
"EC:3.5.1.124",
"METACYC:PWY-1822",
"METACYC:PWY-3602",
"METACYC:PWY-5109",
"METACYC:PWY-5497",
"METACYC:PWY-5784",
"METACYC:PWY-5846",
"METACYC:PWY-6322",
"METACYC:PWY-6409",
"METACYC:PWY-6585",
"METACYC:PWY-6899",
"METACYC:PWY-6917",
"METACYC:PWY-6948",
"M... | 58 | [
"1izy",
"1izz",
"1n57",
"1ons",
"1pv2",
"4i2n",
"4i46",
"4i4n",
"5jzm",
"5jzo",
"5k4a",
"5xr2",
"5xr3"
] | 13 | [
"PUB00044118",
"PUB00044119",
"PUB00044120",
"PUB00060583",
"PUB00060584",
"PUB00060586",
"PUB00079184",
"PUB00079195",
"PUB00153445",
"PUB00159460"
] | [
"15550391",
"17158627",
"16796689",
"12235139",
"12565879",
"21696459",
"26102038",
"26774339",
"28235098",
"35483971"
] | [
"Peptidase activity of the Escherichia coli Hsp31 chaperone.",
"Chaperone Hsp31 contributes to acid resistance in stationary-phase Escherichia coli.",
"Regulation of Escherichia coli hchA, a stress-inducible gene encoding molecular chaperone Hsp31.",
"Hsp31, the Escherichia coli yedU gene product, is a molecu... | [
2005,
2007,
2006,
2002,
2003,
2011,
2015,
2016,
2017,
2022
] | 10 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta"
] | [
999,
227
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein/nucleic acid deglycase HchA | Protein/nucleic acid deglycase HchA | HchA | 3 |
IPR017284 | 17,284 | Tautomerase PptA | Tautomerase_PptA | Family | 726 | false | false | This entry represents tautomerase PptA ( ), a 4-oxalocrotonate tautomerase homologue found in bacteria such as Escherichia coli (in which it is also known as YdcE) [ ]. It functions as a homodimer. Tautomerase PptA can use enol isomers of phenylpyruvate, 2-hydroxy-2,4-pentadienoate and (p-hydroxyphenyl)pyruvate as subs... | [
"GO:0016862",
"GO:0005737"
] | [
"intramolecular oxidoreductase activity, interconverting keto- and enol-groups",
"cytoplasm"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"HAMAP",
"PIRSF"
] | [
"MF_00718",
"PIRSF037799"
] | [
"Tautomerase_PptA",
"Tautomer_YdcE_prd"
] | [
331,
723
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"5.3.2.-",
"PWY-5642",
"PWY-6550"
] | [
"EC:5.3.2.-",
"METACYC:PWY-5642",
"METACYC:PWY-6550"
] | 3 | [
"1gyj",
"1gyx",
"1gyy"
] | 3 | [
"PUB00025426"
] | [
"12356301"
] | [
"The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
724,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Tautomerase PptA | Tautomerase PptA | Tautomerase_PptA | 9 |
IPR017285 | 17,285 | Cyclin, herpesvirus | Cyclin_herpesvir | Family | 17 | false | false | Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [ ], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essenti... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037816"
] | [
"Viral_cyclin"
] | [
17
] | 1 | [] | [] | [] | 0 | [
"1bu2",
"1g3n",
"1jow",
"1xo2",
"2euf",
"2f2c",
"4tth"
] | 7 | [
"PUB00014101",
"PUB00014103"
] | [
"11056549",
"12910258"
] | [
"Cyclin' on the viral path to destruction.",
"Cell cycle regulation and neural differentiation."
] | [
2000,
2003
] | 2 | [
"IPR039361"
] | [] | 1 | 0 | 1 | [
"Rhadinovirus"
] | [
17
] | 1 | [] | [] | 0 | true | Family | Cyclin, herpesvirus | Cyclin, herpesvirus | Cyclin_herpesvir | 6 |
IPR017287 | 17,287 | Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit | Rhodop-sen_GMP-Pdiesterase_dsu | Family | 958 | false | false | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase ( ) is an oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and a delta chain. This protein interacts with RPGR (retinitis pigmentosa GTPase regulator) [ ], ARL2 (Arf-like-2) and ARL3. This entry represents the del... | [
"GO:0050953"
] | [
"sensory perception of light stimulus"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF037825"
] | [
"GMP-Pdiesterase_delta"
] | [
958
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5624958",
"R-BTA-9648002",
"R-CEL-9648002",
"R-CFA-5624958",
"R-CFA-9648002",
"R-DME-9648002",
"R-HSA-5624958",
"R-HSA-9648002",
"R-MMU-5624958",
"R-MMU-9648002"
] | [
"REACTOME:R-BTA-5624958",
"REACTOME:R-BTA-9648002",
"REACTOME:R-CEL-9648002",
"REACTOME:R-CFA-5624958",
"REACTOME:R-CFA-9648002",
"REACTOME:R-DME-9648002",
"REACTOME:R-HSA-5624958",
"REACTOME:R-HSA-9648002",
"REACTOME:R-MMU-5624958",
"REACTOME:R-MMU-9648002"
] | 10 | [
"1ksg",
"1ksh",
"1ksj",
"3t5g",
"3t5i",
"4jhp",
"4jv6",
"4jv8",
"4jvb",
"4jvf",
"5e80",
"5e8f",
"5f2u",
"5ml2",
"5ml3",
"5ml4",
"5ml6",
"5ml8",
"5nal",
"5t4x",
"5tar",
"5tb5",
"5x72",
"5x73",
"5x74",
"5yav",
"5yaw",
"7pac",
"7pad",
"7pae",
"7q9q",
"7q9r"... | 37 | [
"PUB00042676",
"PUB00042677",
"PUB00042678",
"PUB00094361"
] | [
"9990021",
"10452952",
"14561760",
"18503409"
] | [
"The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.",
"Molecular characterization and mapping of canine cGMP-phosphodiesterase delta subunit (PDE6D).",
"Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding... | [
1999,
1999,
2004,
2008
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
958
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
2,
3,
3
] | 6 | true | Family | Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit | Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit | Rhodop-sen_GMP-Pdiesterase_dsu | 6 |
IPR017288 | 17,288 | Bcl-2-like protein 11 | Bcl-2-like_11 | Family | 124 | false | false | Apoptosis, or programmed cell death (PCD), is a common and evolutionarily conserved property of all metazoans [ ]. In many biological processes, apoptosis is required to eliminate supernumerary or dangerous (such as pre-cancerous) cells and to promote normal development. Dysregulation of apoptosis can, therefore, contr... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037827"
] | [
"Bcl-2-like_p11"
] | [
124
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-111446",
"R-HSA-111453",
"R-HSA-193648",
"R-HSA-6802952",
"R-HSA-8862803",
"R-HSA-8952158",
"R-HSA-9607240",
"R-HSA-9614657",
"R-MMU-111446",
"R-MMU-111453",
"R-MMU-193648",
"R-RNO-111446",
"R-RNO-111453",
"R-RNO-193648"
] | [
"REACTOME:R-HSA-111446",
"REACTOME:R-HSA-111453",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-8862803",
"REACTOME:R-HSA-8952158",
"REACTOME:R-HSA-9607240",
"REACTOME:R-HSA-9614657",
"REACTOME:R-MMU-111446",
"REACTOME:R-MMU-111453",
"REACTOME:R-MMU-193648",
"REACTOME:R-RN... | 14 | [] | 0 | [
"PUB00017281",
"PUB00017291",
"PUB00017301"
] | [
"11341280",
"9735050",
"12631689"
] | [
"Apoptosis. Death of a monopoly?",
"The Bcl-2 protein family: arbiters of cell survival.",
"Cellular distribution of Bcl-2 family proteins."
] | [
2001,
1998,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
124
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2
] | 3 | true | Family | Bcl-2-like protein 11 | Bcl-2-like protein 11 | Bcl-2-like_11 | 1 |
IPR017289 | 17,289 | SH2 protein 1A | SH2_prot_1A | Family | 160 | false | false | SH2 domain-containing protein 1A (SH2D1A) is an adaptor protein that appears to regulate B-cell differentiation via switching of SLAM (CD150)-mediated signalling pathways [ ]. The SLAM receptor is expressed on activated T and B lymphocytes. SH2D1A inhibits SLAM self-association. SH2D1A acts by blocking the recruitment ... | [
"GO:0006968",
"GO:0007267",
"GO:0005737"
] | [
"cellular defense response",
"cell-cell signaling",
"cytoplasm"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF037828"
] | [
"SH2_p1A"
] | [
160
] | 1 | [
"REACTOME"
] | [
"R-HSA-198933"
] | [
"REACTOME:R-HSA-198933"
] | 1 | [
"1d1z",
"1d4t",
"1d4w",
"1ka6",
"1ka7",
"1m27"
] | 6 | [
"PUB00042795",
"PUB00042796",
"PUB00042797"
] | [
"15315965",
"11313386",
"11213803"
] | [
"The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells.",
"CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A.",
"X-linked lymphoproliferative disease is caused by deficiency... | [
2004,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
160
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1
] | 3 | true | Family | SH2 protein 1A | SH2 protein 1A | SH2_prot_1A | 8 |
IPR017290 | 17,290 | Ribonuclease H, Bacteroides-type | RNase_H_bac | Family | 1,676 | false | false | This entry represents ribonuclease H (RNase H) from bacteria, especially from Bacteroides. RNase H is an endonuclease that specifically degrades the RNA of RNA-DNA hybrids [ ]. | [
"GO:0004523"
] | [
"RNA-DNA hybrid ribonuclease activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF037839"
] | [
"Ribonuclease_H"
] | [
1676
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00038829"
] | [
"15989951"
] | [
"Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)",
"metagenomes"
] | [
1607,
37,
1,
31
] | 4 | [] | [] | 0 | true | Family | Ribonuclease H, Bacteroides-type | Ribonuclease H, Bacteroides-type | RNase_H_bac | 5 |
IPR017291 | 17,291 | Sulfofructosephosphate aldolase, YihT | SFP_aldolase_YihT | Family | 783 | false | false | This entry represents sulfofructosephosphate aldolase from Enterobacteriaceae. It cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA) [ ]. | [
"GO:0061595",
"GO:1902777"
] | [
"6-deoxy-6-sulfofructose-1-phosphate aldolase activity",
"6-sulfoquinovose(1-) catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF"
] | [
"MF_01912",
"PIRSF037840"
] | [
"SFP_aldolase",
"Aldolase_YihT"
] | [
738,
776
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"4.1.2.57",
"PWY-7446",
"PWY-8350"
] | [
"EC:4.1.2.57",
"METACYC:PWY-7446",
"METACYC:PWY-8350"
] | 3 | [
"1to3",
"7ag1",
"7ag7",
"7ne2"
] | 4 | [
"PUB00074171"
] | [
"24463506"
] | [
"Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."
] | [
2014
] | 1 | [
"IPR002915"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Trichuris trichiura"
] | [
782,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Sulfofructosephosphate aldolase, YihT | Sulfofructosephosphate aldolase, YihT | SFP_aldolase_YihT | 2 |
IPR017293 | 17,293 | N-acetylmuramoyl-L-alanine amidase, YrvJ, predicted | N-acetylmuramoyl-L-ala_amidase | Family | 1,103 | false | false | This group represents a predicted N-acetylmuramoyl-L-alanine amidase, YrvJ type. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037846"
] | [
"Autolysin_YrvJ_prd"
] | [
1103
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
1103
] | 1 | [] | [] | 0 | true | Family | N-acetylmuramoyl-L-alanine amidase, YrvJ, predicted | N-acetylmuramoyl-L-alanine amidase, YrvJ, predicted | N-acetylmuramoyl-L-ala_amidase | 5 |
IPR017294 | 17,294 | Peptidase S8A, subtilisin-related protease, kinetoplastidia | Subtilisin-like_kinetoplast | Family | 10 | false | false | Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes [ ]. The subtilisin-serine p... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037850"
] | [
"Subtilisin_rel_Euglen"
] | [
10
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035098",
"PUB00035099"
] | [
"10656993",
"9572109"
] | [
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway."
] | [
2000,
1998
] | 2 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Trypanosomatidae"
] | [
10
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related protease, kinetoplastidia | Peptidase S8A, subtilisin-related protease, kinetoplastidia | Subtilisin-like_kinetoplast | 8 |
IPR017295 | 17,295 | Peptidase S8A, subtilisin-related, cyanobacteria-1 | Pept_S8A_subtilisin_cyanobac-1 | Family | 326 | false | false | Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes [ ]. The subtilisin-serine p... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037851"
] | [
"Subtilisin_cyano"
] | [
326
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00035098",
"PUB00035099"
] | [
"10656993",
"9572109"
] | [
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway."
] | [
2000,
1998
] | 2 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
326
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, cyanobacteria-1 | Peptidase S8A, subtilisin-related, cyanobacteria-1 | Pept_S8A_subtilisin_cyanobac-1 | 9 |
IPR017296 | 17,296 | Peptidase S8A, SAM-P45 | Peptidase_S8A_SAM-P45 | Family | 847 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). They represent novel peptidases of the subtilisin family from Streptomyces spp [ , ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037852"
] | [
"Subtilisin_rel_SAV5721"
] | [
847
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042745",
"PUB00042746"
] | [
"8990295",
"12039725"
] | [
"A novel member of the subtilisin-like protease family from Streptomyces albogriseolus.",
"Streptomyces serine protease (DHP-A) as a new biocatalyst capable of forming chiral intermediates of 1,4-dihydropyridine calcium antagonists."
] | [
1997,
2002
] | 2 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacillati"
] | [
847
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, SAM-P45 | Peptidase S8A, SAM-P45 | Peptidase_S8A_SAM-P45 | 5 |
IPR017297 | 17,297 | Peptidase S8A, DPH-A | Peptidase_S8A_DPH-A | Family | 911 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037854"
] | [
"Dihydropyridine_esterase"
] | [
911
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00035098",
"PUB00035099",
"PUB00042746"
] | [
"8439290",
"7845208",
"10656993",
"9572109",
"12039725"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway.",
"Streptomyces serine protease (DHP-A) as a new ... | [
1993,
1994,
2000,
1998,
2002
] | 5 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Actinomycetes"
] | [
911
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, DPH-A | Peptidase S8A, DPH-A | Peptidase_S8A_DPH-A | 1 |
IPR017298 | 17,298 | Transcriptional regulator Ure2 | Ure2 | Family | 171 | false | false | Ure2 is a yeast transcriptional regulator that plays an important role in the regulation of nitrogen metabolism [ ]. When easily utilised nitrogen sources are present, yeast cells down-regulate the synthesis of proteins involved in utilising poor nitrogen sources. Ure2 assists this process by interacting with, and repr... | [
"GO:0003714",
"GO:0006808"
] | [
"transcription corepressor activity",
"regulation of nitrogen utilization"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037861"
] | [
"Prion_URE2"
] | [
171
] | 1 | [] | [] | [] | 0 | [
"1g6w",
"1g6y",
"1hqo",
"1jzr",
"1k0a",
"1k0b",
"1k0c",
"1k0d"
] | 8 | [
"PUB00025148",
"PUB00043594",
"PUB00043595"
] | [
"11342133",
"1990286",
"12177423"
] | [
"Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.",
"The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.",
"Conservation of a portion of the S.... | [
2001,
1991,
2002
] | 3 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Dikarya"
] | [
171
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Transcriptional regulator Ure2 | Transcriptional regulator Ure2 | Ure2 | 2 |
IPR017299 | 17,299 | DNA fragmentation factor 45 | DFF45 | Family | 184 | false | false | One of the hallmarks of the terminal stages of apoptosis is internucleosomal DNA breakdown. DNA fragmentation factor (DFF) and endonuclease G (Endo G) are responsible for this process. DFF exists in the nucleus as a heterodimer composed of a 45kDa chaperone and inhibitor subunit (DFF45, also called ICAD-L) and a 40kDa ... | [
"GO:0060703",
"GO:0006309"
] | [
"deoxyribonuclease inhibitor activity",
"apoptotic DNA fragmentation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037865"
] | [
"DFF_alpha"
] | [
184
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-140342",
"R-MMU-140342"
] | [
"REACTOME:R-HSA-140342",
"REACTOME:R-MMU-140342"
] | 2 | [] | 0 | [
"PUB00018568",
"PUB00090023"
] | [
"11371636",
"15723341"
] | [
"Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45.",
"Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G."
] | [
2001,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
184
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
3,
3
] | 5 | true | Family | DNA fragmentation factor 45 | DNA fragmentation factor 45 | DFF45 | 5 |
IPR017300 | 17,300 | Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 | NHERF-1/NHERF-2 | Family | 1,676 | false | false | This entry includes NHERF-1 and NHERF-2. These proteins, which consist of two PDZ domains and a carboxy-terminal ezrin binding domain (EBD) [ ], function as a scaffolding protein for the glutamate transporter GLAST. NHERF1 interacts with GLAST during ER export, while NHERF2 interacts with GLAST in the secretory pathway... | [
"GO:0060090"
] | [
"molecular adaptor activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF037866"
] | [
"EBP50"
] | [
1676
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075053",
"PUB00103873"
] | [
"23200831",
"23583913"
] | [
"Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST.",
"Ligand-induced dynamic changes in extended PDZ domains from NHERF1."
] | [
2013,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1676
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
5,
7
] | 4 | true | Family | Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 | Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 | NHERF-1/NHERF-2 | 3 |
IPR017302 | 17,302 | Neuronal migration protein doublecortin, chordates | DCX_chordates | Family | 810 | false | false | This family represents the neuronal migration protein doublecortin found in chordates. Neuronal migration protein doublecortin (DCX; also known as Lissencephalin-X) is a microtubule-associated protein required for the initial steps of neuronal dispersion and cortex lamination during cerebral cortex development [ , ]. T... | [
"GO:0008017",
"GO:0001764",
"GO:0035082",
"GO:0060041",
"GO:0043005"
] | [
"microtubule binding",
"neuron migration",
"axoneme assembly",
"retina development in camera-type eye",
"neuron projection"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PIRSF"
] | [
"PIRSF037870"
] | [
"Doublin"
] | [
810
] | 1 | [
"REACTOME"
] | [
"R-HSA-447043"
] | [
"REACTOME:R-HSA-447043"
] | 1 | [
"4atu"
] | 1 | [
"PUB00006669",
"PUB00053143",
"PUB00053144",
"PUB00153029"
] | [
"9489699",
"9489700",
"18231966",
"22359282"
] | [
"A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome.",
"Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.",
"Doublecortin (DCX) and double... | [
1998,
1998,
2008,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
810
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
10,
6
] | 3 | true | Family | Neuronal migration protein doublecortin, chordates | Neuronal migration protein doublecortin, chordates | DCX_chordates | 3 |
IPR017303 | 17,303 | Mitochondrial import inner membrane translocase subunit Tim44 | Tim44 | Family | 2,583 | false | false | Tim44 is an essential component of the PAM complex, which is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. It recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy sourc... | [
"GO:0051087",
"GO:0030150"
] | [
"protein-folding chaperone binding",
"protein import into mitochondrial matrix"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF037871",
"TIGR00984"
] | [
"TIM44",
"3a0801s03tim44"
] | [
2561,
571
] | 2 | [
"REACTOME"
] | [
"R-HSA-1268020"
] | [
"REACTOME:R-HSA-1268020"
] | 1 | [
"8e1m",
"8scx"
] | 2 | [
"PUB00062935"
] | [
"10339406"
] | [
"Genetic and structural characterization of the human mitochondrial inner membrane translocase."
] | [
1999
] | 1 | [
"IPR039544"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2583
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
6,
3,
2,
6,
1,
1
] | 8 | true | Family | Mitochondrial import inner membrane translocase subunit Tim44 | Mitochondrial import inner membrane translocase subunit Tim44 | Tim44 | 6 |
IPR017304 | 17,304 | Cytoplasmic protein NCK | NCK | Family | 1,747 | false | false | Cytoplasmic proteins Nck are non-enzymatic adaptor proteins composed of three SH3 (Src homology 3) domains and a C-terminal SH2 domain [ ]. They regulate actin cytoskeleton dynamics by linking proline-rich effector molecules to protein tyrosine kinases and phosphorylated signaling intermediates [ ]. They function downs... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037874"
] | [
"Cytoplasmic_NCK"
] | [
1747
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-186763",
"R-HSA-202433",
"R-HSA-2029482",
"R-HSA-373753",
"R-HSA-3928664",
"R-HSA-418885",
"R-HSA-428540",
"R-HSA-4420097",
"R-HSA-5663213",
"R-HSA-8985801",
"R-HSA-9013420",
"R-HSA-9013424",
"R-HSA-9664422",
"R-HSA-9679191",
"R-HSA-9833482",
"R-HSA-983695",
"R-MMU-186763",
... | [
"REACTOME:R-HSA-186763",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-2029482",
"REACTOME:R-HSA-373753",
"REACTOME:R-HSA-3928664",
"REACTOME:R-HSA-418885",
"REACTOME:R-HSA-428540",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-5663213",
"REACTOME:R-HSA-8985801",
"REACTOME:R-HSA-9013420",
"REACTOME:R-H... | 28 | [] | 0 | [
"PUB00042787",
"PUB00042788",
"PUB00068630",
"PUB00068632",
"PUB00085584"
] | [
"9344857",
"11240126",
"21600986",
"12034353",
"18765673"
] | [
"A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.",
"Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.",
"The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology.",
"The Nck family of ada... | [
1997,
2001,
2011,
2002,
2008
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1747
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
19,
6,
4,
6
] | 5 | true | Family | Cytoplasmic protein NCK | Cytoplasmic protein NCK | NCK | 7 |
IPR017305 | 17,305 | Leupaxin/Paxillin/TGFB1I1 | Tgfb1i1/Leupaxin/TGFB1I1 | Family | 1,548 | false | false | This entry includes the transforming growth factor beta-1-induced transcript 1 (TGFB1I1, also known as Hic-5) protein, paxillin and leupaxin. Hic-5 functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus [ ]. Leupaxin is a transcriptional coac... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037881"
] | [
"Leupaxin"
] | [
1548
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002943",
"PUB00003091",
"PUB00069080",
"PUB00069081"
] | [
"7534286",
"7525621",
"9597752",
"19917054"
] | [
"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL.",
"Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region.",
"Forced expression of hic-5, a senescence-relate... | [
1995,
1994,
1998,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1548
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
4,
6,
11
] | 4 | true | Family | Leupaxin/Paxillin/TGFB1I1 | Leupaxin/Paxillin/TGFB1I1 | Tgfb1i1/Leupaxin/TGFB1I1 | 5 |
IPR017306 | 17,306 | Peptidase S8A, fervidolysin-like | Peptidase_S8A_fervidolysi-like | Family | 68 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). They show protein sequence similarity with Fervidolysin. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037882"
] | [
"Subtilisin_rel_fervidolysin"
] | [
68
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00030557"
] | [
"14687574"
] | [
"Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin."
] | [
2004
] | 1 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Deinococci"
] | [
68
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, fervidolysin-like | Peptidase S8A, fervidolysin-like | Peptidase_S8A_fervidolysi-like | 1 |
IPR017308 | 17,308 | Peptidase S8A, subtilisin-related, bacteroidetes | Pept_S8_subtilisin_bacteroid | Family | 874 | false | false | This entry contains predicted serine peptidases from bacteroidetes belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037892"
] | [
"Subtilisin_rel_SRU_0565"
] | [
874
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacteroidota/Chlorobiota group",
"ecological metagenomes"
] | [
869,
5
] | 2 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, bacteroidetes | Peptidase S8A, subtilisin-related, bacteroidetes | Pept_S8_subtilisin_bacteroid | 9 |
IPR017309 | 17,309 | Peptidase S8A, subtilisin-related, proteobacteria | Pept_S8A_subtilisin_proteobac | Family | 144 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037893"
] | [
"Subtilisin_rel_Maqu_2796"
] | [
144
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00035098",
"PUB00035099"
] | [
"8439290",
"7845208",
"10656993",
"9572109"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway."
] | [
1993,
1994,
2000,
1998
] | 4 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati",
"ecological metagenomes"
] | [
137,
7
] | 2 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, proteobacteria | Peptidase S8A, subtilisin-related, proteobacteria | Pept_S8A_subtilisin_proteobac | 8 |
IPR017310 | 17,310 | Peptidase S8A, subtilisin-related, clostridia | Pept_S8A_subtilisin_clostridia | Family | 1,571 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB), which include unassigned and non-peptidase homologues related to the peptidase CspB from Clostridium perfringens. The CspA, CspB and CspC gene products are encoded by genes that are immediately upstream of two c... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037894"
] | [
"Subtilisin_rel_CspABC"
] | [
1571
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00042764"
] | [
"17038794"
] | [
"Expression of germination-related enzymes, CspA, CspB, CspC, SleC, and SleM, of Clostridium perfringens S40 in the mother cell compartment of sporulating cells."
] | [
2006
] | 1 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacillota",
"bioreactor metagenome"
] | [
1568,
3
] | 2 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, clostridia | Peptidase S8A, subtilisin-related, clostridia | Pept_S8A_subtilisin_clostridia | 2 |
IPR017311 | 17,311 | Peptidase S8A, subtilisin-related, Sama-2696-type | Sama-2696 | Family | 102 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). They represent unassigned subtilisin-related serine peptidases mainly from Shewanella and Pseudoalteromonas, including . | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037895"
] | [
"Subtilisin_rel_Sama_2696"
] | [
102
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR045051"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
102
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, Sama-2696-type | Peptidase S8A, subtilisin-related, Sama-2696-type | Sama-2696 | 3 |
IPR017312 | 17,312 | Peptidase S8A, subtilisin-related, Alteromonadales | Subtilisin_Alteromonadales | Family | 153 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). They represent unassigned subtilisin-related serine peptidases mostly from Alteromonadales. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037898"
] | [
"Subtilisin_rel_Sputw3181_3341"
] | [
153
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR045051"
] | [] | 1 | 0 | 1 | [
"Gammaproteobacteria",
"marine sediment metagenome"
] | [
152,
1
] | 2 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, Alteromonadales | Peptidase S8A, subtilisin-related, Alteromonadales | Subtilisin_Alteromonadales | 7 |
IPR017314 | 17,314 | Peptidase S8A, subtilisin-like peptidase 1, plasmodium | Pept_S8A_PfSUB_1 | Family | 21 | false | false | This entry contains serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB). All of the peptidases in this entry derive from Plasmodium spp. and are called 'subtilisin-like peptidase 1'. The peptidase in Plasmodium falciparum (isolate 3D7) termed pfSUB1 is a component of the exoneme [ ].... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037900"
] | [
"Subtilisin_rel_PfSUB_1"
] | [
21
] | 1 | [
"EC",
"REACTOME"
] | [
"3.4.21.62",
"R-PFA-2173796"
] | [
"EC:3.4.21.62",
"REACTOME:R-PFA-2173796"
] | 2 | [
"8pol"
] | 1 | [
"PUB00042776",
"PUB00042777"
] | [
"18083092",
"18083098"
] | [
"The exoneme helps malaria parasites to break out of blood cells.",
"Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes."
] | [
2007,
2007
] | 2 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Plasmodium"
] | [
21
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-like peptidase 1, plasmodium | Peptidase S8A, subtilisin-like peptidase 1, plasmodium | Pept_S8A_PfSUB_1 | 1 |
IPR017315 | 17,315 | Peptidase S8A, subtilisin-related, proteobacteria-2 | Pep_S8A_subtilisin_pbac-2 | Family | 133 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037901"
] | [
"Subtilisin_rel_Nmul_A1891"
] | [
133
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00035098",
"PUB00035099"
] | [
"8439290",
"7845208",
"10656993",
"9572109"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway."
] | [
1993,
1994,
2000,
1998
] | 4 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati"
] | [
133
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, proteobacteria-2 | Peptidase S8A, subtilisin-related, proteobacteria-2 | Pep_S8A_subtilisin_pbac-2 | 4 |
IPR017316 | 17,316 | Peptidase S8A, subtilisin-related, cyanobacteria-2 | Pept_S8A_subtilisin_cyanobac-2 | Family | 3 | false | false | This entry contains predicted subtilisin-related peptidases, predominantly found in cyanobacterial species. The peptides belong to MEROPS peptidase family S8A (subtilisin family, clan SB), and are unassigned. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037902"
] | [
"Subtilisin_rel_Ava_4226"
] | [
3
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Nostocaceae"
] | [
3
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, cyanobacteria-2 | Peptidase S8A, subtilisin-related, cyanobacteria-2 | Pept_S8A_subtilisin_cyanobac-2 | 9 |
IPR017317 | 17,317 | Peptidase S8A, subtilisin-related, bacteroidetes-2 | Pept_S8_subtilisin_bacteroid-2 | Family | 1,489 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037903"
] | [
"Subtilisin_rel_GFO_2223"
] | [
1489
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00035098",
"PUB00035099"
] | [
"8439290",
"7845208",
"10656993",
"9572109"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway."
] | [
1993,
1994,
2000,
1998
] | 4 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
1462,
27
] | 2 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, bacteroidetes-2 | Peptidase S8A, subtilisin-related, bacteroidetes-2 | Pept_S8_subtilisin_bacteroid-2 | 7 |
IPR017318 | 17,318 | Peptidase S8A, subtilisin-related, campylobacter | Pept_S8A_subtilisin_campylobac | Family | 94 | false | false | This entry contains unassigned serine peptidases belonging to MEROPS peptidase family S8A (subtilisin family, clan SB) from Campylobacter. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037905"
] | [
"Subtilisin_rel_CJE1557"
] | [
94
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Pseudomonadati"
] | [
94
] | 1 | [] | [] | 0 | true | Family | Peptidase S8A, subtilisin-related, campylobacter | Peptidase S8A, subtilisin-related, campylobacter | Pept_S8A_subtilisin_campylobac | 7 |
IPR017319 | 17,319 | Subtilisin-like serine protease TK1689-type | Subtilisin_TK1689 | Family | 34 | false | false | Limited proteolysis of most large protein precursors is carried out in vivo by the subtilisin-like pro-protein convertases. Many important biological processes such as peptide hormone synthesis, viral protein processing and receptor maturation involve proteolytic processing by these enzymes [ ]. The subtilisin-serine p... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037907"
] | [
"Subtilisin_rel_TK1689"
] | [
34
] | 1 | [] | [] | [] | 0 | [
"3afg"
] | 1 | [
"PUB00035098",
"PUB00035099",
"PUB00073588"
] | [
"10656993",
"9572109",
"20100702"
] | [
"Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications.",
"Subtilisin-related serine proteases in the mammalian constitutive secretory pathway.",
"Subtilisin-like serine protease from hyperthermophilic archaeon Thermococcus kodakaraensis with N- and C-terminal propeptide... | [
2000,
1998,
2010
] | 3 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Thermoanaerobacteraceae",
"Thermococcaceae"
] | [
15,
19
] | 2 | [] | [] | 0 | true | Family | Subtilisin-like serine protease TK1689-type | Subtilisin-like serine protease TK1689-type | Subtilisin_TK1689 | 5 |
IPR017321 | 17,321 | Histone deacetylase class II, yeast | Hist_deAcase_II_yeast | Family | 1,106 | false | false | This group represents a histone deacetylase class II from yeast. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037919"
] | [
"HDAC_II_yeast"
] | [
1106
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1.98",
"R-SCE-3214815",
"R-SCE-3371511",
"R-SCE-4551638",
"R-SPO-3214815",
"R-SPO-3371511",
"R-SPO-4551638"
] | [
"EC:3.5.1.98",
"REACTOME:R-SCE-3214815",
"REACTOME:R-SCE-3371511",
"REACTOME:R-SCE-4551638",
"REACTOME:R-SPO-3214815",
"REACTOME:R-SPO-3371511",
"REACTOME:R-SPO-4551638"
] | 7 | [
"5ikk",
"6z6f",
"6z6h",
"6z6o",
"6z6p"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
1106
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Histone deacetylase class II, yeast | Histone deacetylase class II, yeast | Hist_deAcase_II_yeast | 5 |
IPR017322 | 17,322 | Receptor-interacting serine/threonine-protein kinase 2 | Rcpt-int_Ser/Thr_kinase-2 | Family | 354 | false | false | This entry represents receptor-interacting serine/threonine-protein kinase 2 (RIP2), which functions in the phosphorylation ( ) of its protein target. This enzyme activates pro-caspase-1 and pro-caspase-8, and it thought to potentiate CASP8-mediated apoptosis [ ]. It also activates NF-kappa-B. RIP2 undergoes autophosph... | [
"GO:0004674",
"GO:0043065",
"GO:0005737"
] | [
"protein serine/threonine kinase activity",
"positive regulation of apoptotic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF037921"
] | [
"STPK_RIP2"
] | [
354
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.10.2",
"2.7.11.1",
"R-BTA-168638",
"R-BTA-202424",
"R-BTA-209543",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5689896",
"R-HSA-168638",
"R-HSA-202424",
"R-HSA-209543",
"R-HSA-445989",
"R-HSA-450302",
"R-HSA-450321",
"R-HSA-5689896",
"R-HSA-9020702",
"R-HSA-9705671",
"R-MMU-168638"... | [
"EC:2.7.10.2",
"EC:2.7.11.1",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-209543",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-5689896",
"REACTOME:R-HSA-168638",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-209543",
"REACTOME:R-HSA-445989",
"REACTOME:R... | 23 | [] | 0 | [
"PUB00044623"
] | [
"17186025"
] | [
"Regulation of Nod1-mediated signaling pathways."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
354
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
2,
2
] | 4 | true | Family | Receptor-interacting serine/threonine-protein kinase 2 | Receptor-interacting serine/threonine-protein kinase 2 | Rcpt-int_Ser/Thr_kinase-2 | 5 |
IPR017324 | 17,324 | Transmembrane protease serine 9 | Tmprss9 | Family | 9 | false | false | This entry represents transmembrane serine protease 9 (also known as polyserase-1) ( ), which belongs to MEROPS peptidase family S1A (clan PA(S)). It is encoded by the TMPRSS9 gene on chromosome 19p13 in Homo sapiens. This protein is synthesised as a membrane-associated polyprotein which undergoes post-translational cl... | [
"GO:0004252",
"GO:0005886"
] | [
"serine-type endopeptidase activity",
"plasma membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PIRSF"
] | [
"PIRSF037931"
] | [
"TMPRSS9_polyserase-1"
] | [
9
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [
"PUB00035951",
"PUB00044624",
"PUB00044625"
] | [
"12886014",
"16872279",
"17655505"
] | [
"Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.",
"Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminogl... | [
2003,
2006,
2007
] | 3 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Euarchontoglires"
] | [
9
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2
] | 3 | true | Family | Transmembrane protease serine 9 | Transmembrane protease serine 9 | Tmprss9 | 5 |
IPR017325 | 17,325 | RNA binding protein fox-1 homolog 1-3 | RBFOX1-3 | Family | 6,349 | false | false | This entry represents RNA binding protein fox-1 homologue 1-3 (RBFOX1-3) and its homologues predominantly found in vertebrates. Members of this family regulate alternative splicing events by binding to 5'-UGCAUGU-3' elements [ , ]. | [
"GO:0003723",
"GO:0043484"
] | [
"RNA binding",
"regulation of RNA splicing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037932"
] | [
"Ataxin_2_bd_A2BP"
] | [
6349
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803529",
"R-HSA-9022707",
"R-HSA-9768919"
] | [
"REACTOME:R-HSA-6803529",
"REACTOME:R-HSA-9022707",
"REACTOME:R-HSA-9768919"
] | 3 | [] | 0 | [
"PUB00057858",
"PUB00057859"
] | [
"16537540",
"15824060"
] | [
"Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16.",
"Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities."
] | [
2006,
2005
] | 2 | [
"IPR047131"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
6349
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
118,
33,
11,
21
] | 4 | true | Family | RNA binding protein fox-1 homolog 1-3 | RNA binding protein fox-1 homolog 1-3 | RBFOX1-3 | 5 |
IPR017326 | 17,326 | Peptidase S1A, polyserase-2 | Pept_S1A_polyserase-2 | Family | 151 | false | false | This entry represents serine peptidases that belong to MEROPS petidase family S1A (clan PA(S)). They are a novel enzyme with three tandem serine protease domains in a single polypeptide chain. Polyserase-2 (polyserine protease-2) is the second identified human enzyme with several tandem serine protease domains. The fir... | [
"GO:0004252"
] | [
"serine-type endopeptidase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF037933"
] | [
"Polyserase-2"
] | [
151
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [
"PUB00035952"
] | [
"15536082"
] | [
"Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain."
] | [
2005
] | 1 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Eutheria"
] | [
151
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
4
] | 3 | true | Family | Peptidase S1A, polyserase-2 | Peptidase S1A, polyserase-2 | Pept_S1A_polyserase-2 | 3 |
IPR017327 | 17,327 | Peptidase S1A, TMPRSS13 | Peptidase_S1A_TMPRSS13 | Family | 26 | false | false | This group represents type II transmembrane serine proteases or TTSPs that belong to MEROPS peptidase family S1A (clan PA(S)). They proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037935"
] | [
"TMPRSS13"
] | [
26
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054062"
] | [
"2021990"
] | [
"Diphenhydramine prevents the haemodynamic changes of cimetidine in ICU patients."
] | [
1991
] | 1 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Euarchontoglires"
] | [
26
] | 1 | [
"Homo sapiens",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | Peptidase S1A, TMPRSS13 | Peptidase S1A, TMPRSS13 | Peptidase_S1A_TMPRSS13 | 4 |
IPR017328 | 17,328 | Sirtuin, class I | Sirtuin_class_I | Family | 2,808 | false | false | This entry represents eukaryotic type sirtuin-2 (Sir2, or silent information regulator) family of NAD-dependent deacetylases, which are nicotinamide adenine dinucleotide (NAD+)-dependent enzymes that hydrolyse one molecule of NAD+ for every lysine residue that is deacetylated [ ]. The sirtuins are phylogenetically cons... | [
"GO:0017136",
"GO:0051287"
] | [
"histone deacetylase activity, NAD-dependent",
"NAD binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF"
] | [
"PIRSF037938"
] | [
"SIR2_euk"
] | [
2808
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.1.286",
"R-DME-2995383",
"R-DRE-2995383",
"R-HSA-2995383",
"R-MMU-2151201",
"R-MMU-2995383",
"R-MMU-9617629",
"R-MMU-9841251",
"R-MMU-9854311",
"R-RNO-2995383",
"R-SCE-2151201",
"R-SPO-2151201"
] | [
"EC:2.3.1.286",
"REACTOME:R-DME-2995383",
"REACTOME:R-DRE-2995383",
"REACTOME:R-HSA-2995383",
"REACTOME:R-MMU-2151201",
"REACTOME:R-MMU-2995383",
"REACTOME:R-MMU-9617629",
"REACTOME:R-MMU-9841251",
"REACTOME:R-MMU-9854311",
"REACTOME:R-RNO-2995383",
"REACTOME:R-SCE-2151201",
"REACTOME:R-SPO-21... | 12 | [
"1j8f",
"1q14",
"1q17",
"1q1a",
"1szc",
"1szd",
"2od2",
"2od7",
"2od9",
"2qqf",
"2qqg",
"3glr",
"3gls",
"3glt",
"3glu",
"3zgo",
"3zgv",
"4bn4",
"4bn5",
"4bv3",
"4bvb",
"4bve",
"4bvf",
"4bvg",
"4bvh",
"4c78",
"4c7b",
"4fvt",
"4fz3",
"4hd8",
"4jsr",
"4jt8"... | 131 | [
"PUB00044690",
"PUB00044691"
] | [
"14742637",
"18729382"
] | [
"Diversity in the Sir2 family of protein deacetylases.",
"Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase."
] | [
2004,
2008
] | 2 | [
"IPR003000"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2808
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
8,
3,
4,
6,
1,
9,
1,
1
] | 8 | true | Family | Sirtuin, class I | Sirtuin, class I | Sirtuin_class_I | 8 |
IPR017330 | 17,330 | Sperm-associated antigen 7 | SPAG7 | Family | 1,137 | false | false | The function of SPAG7 is not clear. It has been linked to an auto-inflammatory disease-periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome [ ]. | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037943",
"PTHR13498"
] | [
"Sperm-assoc_antigen_PAG7",
""
] | [
724,
1137
] | 2 | [] | [] | [] | 0 | [
"2cpm"
] | 1 | [
"PUB00074895"
] | [
"24452265"
] | [
"SPAG7 is a candidate gene for the periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1137
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
4,
2,
4
] | 5 | true | Family | Sperm-associated antigen 7 | Sperm-associated antigen 7 | SPAG7 | 4 |
IPR017331 | 17,331 | Peptidoglycan recognition protein, PGRP-S | Peptidoglycan_recognition | Family | 1,755 | false | false | PGRP-S (peptidoglycan recognition protein short, also known as peptidoglycan recognition protein 1) is a innate immunity pattern recognition protein conserved from insects to mammals, recognising bacterial cell wall peptidoglycan and activates two antimicrobial defense systems, prophenoloxidase cascade and antimicrobia... | [
"GO:0042834",
"GO:0045087"
] | [
"peptidoglycan binding",
"innate immune response"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF037945"
] | [
"PGRPs"
] | [
1755
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-6803157",
"R-DME-6798695",
"R-DME-6803157",
"R-HSA-6798695",
"R-HSA-6803157",
"R-MMU-6798695",
"R-MMU-6803157",
"R-RNO-6798695",
"R-RNO-6803157"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6803157",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-6803157",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6803157",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-6803157",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-6803157"
] | 10 | [
"1oht",
"1s2j",
"1sk3",
"1sk4",
"1sxr",
"1twq",
"1yck",
"2aph",
"2cb3",
"2f2l",
"2r2k",
"2r90",
"2rkq",
"2xz4",
"2z9n",
"3c2x",
"3cg9",
"3cor",
"3cxa",
"3ng4",
"3nno",
"3nw3",
"3o4k",
"3ogx",
"3qj1",
"3qs0",
"3qv4",
"3rt4",
"3t2v",
"3t39",
"3tru",
"3uil"... | 59 | [
"PUB00083895",
"PUB00083896"
] | [
"12649138",
"23149273"
] | [
"Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice.",
"Structural basis of the binding of fatty acids to peptidoglycan recognition protein, PGRP-S through second binding site."
] | [
2003,
2013
] | 2 | [
"IPR015510"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1755
] | 1 | [
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
1,
2,
3
] | 4 | true | Family | Peptidoglycan recognition protein, PGRP-S | Peptidoglycan recognition protein, PGRP-S | Peptidoglycan_recognition | 6 |
IPR017333 | 17,333 | Uncharacterised conserved protein UCP037948, zinc finger MYND-type | UCP037948_Znf-MYND | Family | 221 | false | false | This group represents an uncharacterised protein with a C-terminal zinc finger MYND domain. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037948"
] | [
"UCP037948_Znf_MYND10"
] | [
221
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
221
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
1,
1
] | 5 | true | Family | Uncharacterised conserved protein UCP037948, zinc finger MYND-type | Uncharacterised conserved protein UCP037948, zinc finger MYND-type | UCP037948_Znf-MYND | 7 |
IPR017335 | 17,335 | E3 ubiquitin-protein ligase RNF8 | RNF8 | Family | 983 | false | false | This entry represents E3 ubiquitin-protein ligase RNF8, which may be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. This enzyme promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-... | [
"GO:0004842",
"GO:0006302",
"GO:0006974",
"GO:0016567",
"GO:0005634"
] | [
"ubiquitin-protein transferase activity",
"double-strand break repair",
"DNA damage response",
"protein ubiquitination",
"nucleus"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"HAMAP",
"PIRSF"
] | [
"MF_03067",
"PIRSF037950"
] | [
"RNF8",
"E3_ubiquit_lig_RNF8"
] | [
983,
194
] | 2 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-BTA-5693565",
"R-BTA-5693571",
"R-BTA-5693607",
"R-BTA-69473",
"R-HSA-5693565",
"R-HSA-5693571",
"R-HSA-5693607",
"R-HSA-69473",
"R-MMU-5693565",
"R-MMU-5693571",
"R-MMU-5693607",
"R-MMU-69473",
"R-RNO-5693565",
"R-RNO-5693571",
"R-RNO-5693607",
"R-RNO-69... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-5693565",
"REACTOME:R-BTA-5693571",
"REACTOME:R-BTA-5693607",
"REACTOME:R-BTA-69473",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-69473",
"REACTOME:R-MMU-5693565",
"REACTOME:R-MMU-5693571",
"... | 18 | [] | 0 | [
"PUB00015623",
"PUB00015624",
"PUB00044635",
"PUB00044636",
"PUB00044637",
"PUB00044638"
] | [
"12646216",
"15564047",
"18793138",
"18202552",
"16488448",
"14976165"
] | [
"U-box proteins as a new family of ubiquitin ligases.",
"The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.",
"Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking.",
"Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/... | [
2003,
2004,
2008,
2008,
2006,
2004
] | 6 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
983
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
3,
2
] | 4 | true | Family | E3 ubiquitin-protein ligase RNF8 | E3 ubiquitin-protein ligase RNF8 | RNF8 | 4 |
IPR017336 | 17,336 | Snurportin-1 | Snurportin-1 | Family | 3,042 | false | false | Snurportin-1 is a nuclear import receptor that contains an N-terminal importin beta binding domain which is essential for its function as an snRNP-specific nuclear import receptor [ ]. Snurportin-1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and di... | [
"GO:0061015",
"GO:0005634",
"GO:0005737"
] | [
"snRNA import into nucleus",
"nucleus",
"cytoplasm"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF037955",
"PTHR13403"
] | [
"Snurportin-1",
""
] | [
649,
3042
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-191859",
"R-HSA-191859",
"R-MMU-191859",
"R-RNO-191859"
] | [
"REACTOME:R-BTA-191859",
"REACTOME:R-HSA-191859",
"REACTOME:R-MMU-191859",
"REACTOME:R-RNO-191859"
] | 4 | [
"1xk5",
"2qna",
"3gb8",
"3gjx",
"3nby",
"3nbz",
"3nc0",
"5dis"
] | 8 | [
"PUB00033726"
] | [
"9670026"
] | [
"Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3042
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
1,
12,
1,
6,
1,
4,
6,
5
] | 9 | true | Family | Snurportin-1 | Snurportin-1 | Snurportin-1 | 5 |
IPR017337 | 17,337 | Zinc finger Ran-binding domain-containing protein 2 | ZRANB2 | Family | 1,561 | false | false | ZRANB2 is a splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. It may interfere with constitutive 5'-splice site selection [ ]. | [
"GO:0006396"
] | [
"RNA processing"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF037956"
] | [
"UCP037956_ZnF_Ran"
] | [
1561
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098086"
] | [
"11448987"
] | [
"ZNF265--a novel spliceosomal protein able to induce alternative splicing."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1561
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
1,
4,
6
] | 6 | true | Family | Zinc finger Ran-binding domain-containing protein 2 | Zinc finger Ran-binding domain-containing protein 2 | ZRANB2 | 2 |
IPR017339 | 17,339 | Lytic switch protein BZLF1, human herpesvirus 4 | BZLF1_HHV-4 | Family | 57 | false | false | This family represents thelytic switch protein BZLF1 from Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4). It is a transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle of infection in cells containing a highly met... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037966"
] | [
"BZLF1"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00101892",
"PUB00101893",
"PUB00101894"
] | [
"30926617",
"34893887",
"15361873"
] | [
"BZLF1 interacts with chromatin remodelers promoting escape from latent infections with EBV.",
"Structural basis of DNA methylation-dependent site selectivity of the Epstein-Barr virus lytic switch protein ZEBRA/Zta/BZLF1.",
"The EBV lytic switch protein, Z, preferentially binds to and activates the methylated ... | [
2019,
2022,
2004
] | 3 | [] | [] | 0 | 0 | null | [
"Lymphocryptovirus"
] | [
57
] | 1 | [] | [] | 0 | true | Family | Lytic switch protein BZLF1, human herpesvirus 4 | Lytic switch protein BZLF1, human herpesvirus 4 | BZLF1_HHV-4 | 4 |
IPR017340 | 17,340 | U1 small nuclear ribonucleoprotein C | U1_snRNP-C | Family | 4,434 | false | false | This group represents U1 small nuclear ribonucleoprotein C. It is a component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative... | [
"GO:0030627",
"GO:0000395",
"GO:0000398",
"GO:0005685"
] | [
"pre-mRNA 5'-splice site binding",
"mRNA 5'-splice site recognition",
"mRNA splicing, via spliceosome",
"U1 snRNP"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PIRSF",
"PANTHER"
] | [
"MF_03153",
"PIRSF037969",
"PTHR31148"
] | [
"U1_C",
"U1_snRNP-C",
""
] | [
3666,
2894,
4328
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-72163",
"R-CFA-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163"
] | [
"REACTOME:R-BTA-72163",
"REACTOME:R-CFA-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163"
] | 5 | [
"2vrd",
"3cw1",
"4pjo",
"5zwn",
"6g90",
"6n7p",
"6n7r",
"6n7x",
"6qx9",
"7oqc",
"7oqe",
"7vpx",
"8w2o"
] | 13 | [
"PUB00018162",
"PUB00064751",
"PUB00064752"
] | [
"8798632",
"2136774",
"1826349"
] | [
"Involvement of U1 small nuclear ribonucleoproteins (snRNP) in 5' splice site-U1 snRNP interaction.",
"U1-specific protein C needed for efficient complex formation of U1 snRNP with a 5' splice site.",
"Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP."
] | [
1996,
1990,
1991
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4434
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
2,
5,
4,
1,
2,
5,
1,
1,
5
] | 12 | true | Family | U1 small nuclear ribonucleoprotein C | U1 small nuclear ribonucleoprotein C | U1_snRNP-C | 4 |
IPR017341 | 17,341 | Membrane cofactor protein CD46 | CD46 | Family | 828 | false | false | This entry represents a group of membrane cofactor proteins (also known as CD46 or TLX). Human CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue [ ]. Rat CD46 may be involved in the fusio... | [
"GO:0009986"
] | [
"cell surface"
] | [
"cellular_component"
] | 1 | [
"PIRSF"
] | [
"PIRSF037971"
] | [
"TLX_CD46"
] | [
828
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-977606",
"R-MMU-977606",
"R-RNO-977606"
] | [
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-977606",
"REACTOME:R-RNO-977606"
] | 3 | [
"8cjv",
"8qk3"
] | 2 | [
"PUB00073657",
"PUB00073658"
] | [
"10843656",
"15215199"
] | [
"Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation.",
"Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3."
] | [
2000,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
828
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
3
] | 3 | true | Family | Membrane cofactor protein CD46 | Membrane cofactor protein CD46 | CD46 | 6 |
IPR017342 | 17,342 | S-adenosyl-L-methionine dependent methionine synthase, predicted | S-AdoMet-dep_Met_synth_prd | Family | 704 | false | false | This entry represents proteins predicted to function as S-adenosyl-L-methionine dependent methionine synthases, such as the uncharacterised protein TM0269 from Thermotoga maritima. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037984"
] | [
"Met_synth_TM0269_prd"
] | [
704
] | 1 | [] | [] | [] | 0 | [
"1j6r"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Promethearchaeum syntrophicum",
"metagenomes"
] | [
697,
1,
6
] | 3 | [] | [] | 0 | true | Family | S-adenosyl-L-methionine dependent methionine synthase, predicted | S-adenosyl-L-methionine dependent methionine synthase, predicted | S-AdoMet-dep_Met_synth_prd | 8 |
IPR017343 | 17,343 | Uncharacterised conserved protein UCP037987 | UCP037987 | Family | 17 | false | false | This group represents a uncharacterised conserved proteins from enterobacteriaceae. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037987"
] | [
"UCP037987"
] | [
17
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Diptera"
] | [
17
] | 1 | [
"Drosophila melanogaster"
] | [
3
] | 1 | true | Family | Uncharacterised conserved protein UCP037987 | Uncharacterised conserved protein UCP037987 | UCP037987 | 2 |
IPR017344 | 17,344 | Uncharacterised conserved protein UCP037988,TerD, trypsin | UCP037988 | Family | 47 | false | false | This group represents an uncharacterised protein with partial TerD and trypsin domains. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037988"
] | [
"UCP037988"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR008256"
] | [] | 1 | 0 | 1 | [
"Pseudomonas syringae group"
] | [
47
] | 1 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP037988,TerD, trypsin | Uncharacterised conserved protein UCP037988,TerD, trypsin | UCP037988 | 2 |
IPR017345 | 17,345 | Peptidase S1A, Tysnd1 | Pept_S1A_Tysnd1 | Family | 2 | false | false | Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037989"
] | [
"Peptidase_S1B_Tysnd1"
] | [
2
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9033241",
"R-HSA-9033500",
"R-MMU-9033241",
"R-MMU-9033500"
] | [
"REACTOME:R-HSA-9033241",
"REACTOME:R-HSA-9033500",
"REACTOME:R-MMU-9033241",
"REACTOME:R-MMU-9033500"
] | 4 | [] | 0 | [
"PUB00000522",
"PUB00003576",
"PUB00043397"
] | [
"8439290",
"7845208",
"17255948"
] | [
"Evolutionary families of peptidases.",
"Families of serine peptidases.",
"Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids."
] | [
1993,
1994,
2007
] | 3 | [
"IPR039245"
] | [] | 1 | 0 | 1 | [
"Euarchontoglires"
] | [
2
] | 1 | [
"Homo sapiens",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | Peptidase S1A, Tysnd1 | Peptidase S1A, Tysnd1 | Pept_S1A_Tysnd1 | 9 |
IPR017346 | 17,346 | UBX domain-containing protein 2/7 | UBX_7/2 | Family | 1,423 | false | false | This entry represents UBX domain-containing proteins 2 (Ubx2) and 7 (UBXN7). VCP/p97 or Cdc48 is a eukaryotic ATPase involved in membrane fusion, protein transport, and protein degradation. Ubx2 interacts with Cdc48 in fission yeast [ ]. UBXN7 is a ubiquitin-binding adapter that links a subset of NEDD8-associated culli... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037991"
] | [
"UCP037991_UBX7/2"
] | [
1423
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-8951664",
"R-DDI-9755511",
"R-HSA-8951664",
"R-HSA-9755511",
"R-MMU-8951664",
"R-MMU-9755511",
"R-SPO-8951664",
"R-SPO-9755511"
] | [
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9755511",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-9755511",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-9755511",
"REACTOME:R-SPO-8951664",
"REACTOME:R-SPO-9755511"
] | 8 | [] | 0 | [
"PUB00020518",
"PUB00073651"
] | [
"15120077",
"22537386"
] | [
"The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes.",
"UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation."
] | [
2004,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1423
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
5,
2,
2,
2,
3,
3,
5,
1,
6
] | 9 | true | Family | UBX domain-containing protein 2/7 | UBX domain-containing protein 2/7 | UBX_7/2 | 2 |
IPR017347 | 17,347 | Heterogeneous nuclear ribonucleoprotein C | hnRNP_C | Family | 2,682 | false | false | This entry represents heterogeneous nuclear ribonucleoproteins C and C-like. The physiologically active form of human heterogeneous nuclear ribonucleoprotein C (hnRNPC) is a tetramer of isoforms hnRNPC1 and C2. It binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single hnRNPC tetramers bind 230-240 nuc... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF037992"
] | [
"hnRNP-C_Raly"
] | [
2682
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-4570464",
"R-HSA-72163",
"R-HSA-72203",
"R-HSA-9013418",
"R-HSA-9013422",
"R-MMU-4570464",
"R-MMU-72163",
"R-MMU-72203",
"R-MMU-9013418",
"R-MMU-9013422",
"R-RNO-4570464",
"R-RNO-72163",
"R-RNO-72203",
"R-RNO-9013418",
"R-RNO-9013422"
] | [
"REACTOME:R-HSA-4570464",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-9013418",
"REACTOME:R-HSA-9013422",
"REACTOME:R-MMU-4570464",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72203",
"REACTOME:R-MMU-9013418",
"REACTOME:R-MMU-9013422",
"REACTOME:R-RNO-4570464",
"REACTOME:R-RNO-... | 15 | [] | 0 | [
"PUB00072919",
"PUB00072920",
"PUB00072921",
"PUB00072922",
"PUB00073767"
] | [
"8264621",
"7567451",
"12509468",
"16010978",
"10500250"
] | [
"The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.",
"A T to G mutation in the polypyrimidine tract of the second intron of the human beta-globin gene reduces in vitro splicing efficiency: evidence for an increased ... | [
1994,
1995,
2003,
2005,
1999
] | 5 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2682
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
21,
7,
12
] | 4 | true | Family | Heterogeneous nuclear ribonucleoprotein C | Heterogeneous nuclear ribonucleoprotein C | hnRNP_C | 2 |
IPR017348 | 17,348 | Serine/threonine-protein kinase pim-1/2/3 | PIM1/2/3 | Family | 2,790 | false | false | This entry represents serine/threonine-protein kinase Pim-1/2/3. They are a group of proto-oncogenes with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation [ , , ]. | [
"GO:0004674",
"GO:0006468",
"GO:0043066"
] | [
"protein serine/threonine kinase activity",
"protein phosphorylation",
"negative regulation of apoptotic process"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PIRSF"
] | [
"PIRSF037993"
] | [
"STPK_Pim-1"
] | [
2790
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-HSA-6785807",
"R-HSA-9702518",
"R-HSA-9703465"
] | [
"EC:2.7.11.1",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-9702518",
"REACTOME:R-HSA-9703465"
] | 4 | [
"1xqz",
"1xr1",
"1xws",
"1yhs",
"1yi3",
"1yi4",
"1ywv",
"1yxs",
"1yxt",
"1yxu",
"1yxv",
"1yxx",
"2bik",
"2bil",
"2bzh",
"2bzi",
"2bzj",
"2bzk",
"2c3i",
"2iwi",
"2j2i",
"2o3p",
"2o63",
"2o64",
"2o65",
"2obj",
"2oi4",
"2xix",
"2xiy",
"2xiz",
"2xj0",
"2xj1"... | 192 | [
"PUB00073463",
"PUB00073464",
"PUB00073465"
] | [
"19749799",
"20307683",
"17270021"
] | [
"PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis.",
"Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.",
"Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can pr... | [
2009,
2010,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Armadillidium vulgare iridescent virus",
"Eukaryota",
"viral metagenome"
] | [
1,
2787,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
33,
4,
6,
9
] | 4 | true | Family | Serine/threonine-protein kinase pim-1/2/3 | Serine/threonine-protein kinase pim-1/2/3 | PIM1/2/3 | 3 |
IPR017351 | 17,351 | LIM and senescent cell antigen-like-containing domain protein 1-4-like | PINCH-1-4-like | Family | 5,278 | false | false | This group represents LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1, also known as PINCH-1), and its homologues LIMS2-4, LIM domain-containing protein unc-97 and LIM domain-containing protein pin-2. LIMS1 is LIM domain adapter protein that functions in the integrin and growth factor signal tran... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24210"
] | [
""
] | [
5278
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-446353",
"R-CEL-446353",
"R-CEL-446388",
"R-DDI-8849471",
"R-HSA-446353",
"R-HSA-446388",
"R-MMU-446353",
"R-MMU-446388"
] | [
"REACTOME:R-BTA-446353",
"REACTOME:R-CEL-446353",
"REACTOME:R-CEL-446388",
"REACTOME:R-DDI-8849471",
"REACTOME:R-HSA-446353",
"REACTOME:R-HSA-446388",
"REACTOME:R-MMU-446353",
"REACTOME:R-MMU-446388"
] | 8 | [
"1g47",
"1nyp",
"1u5s",
"2cor",
"2d8x",
"2kbx",
"3f6q",
"3ixe",
"4hi8",
"4hi9",
"6mif",
"7d2s",
"7d2t",
"7d2u",
"7lt9"
] | 15 | [
"PUB00028536",
"PUB00042822",
"PUB00101471",
"PUB00101472",
"PUB00151215"
] | [
"11078733",
"18187956",
"12808046",
"22253611",
"12651156"
] | [
"Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain.",
"Expression of PINCH protein in gliomas and its clinicopathological significance.",
"Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a ... | [
2001,
2007,
2003,
2012,
2003
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5278
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
4,
26,
13,
16
] | 6 | true | Family | LIM and senescent cell antigen-like-containing domain protein 1-4-like | LIM and senescent cell antigen-like-containing domain protein 1-4-like | PINCH-1-4-like | 4 |
IPR017352 | 17,352 | Methyl-CpG-binding domain protein 4 | MBD4 | Family | 492 | false | false | Methyl-CpG-binding domain protein 4 (MBD4) is a mismatch-specific DNA N-glycosylase involved in DNA repair. It has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites [ , ]. | [
"GO:0003677",
"GO:0008263",
"GO:0006281"
] | [
"DNA binding",
"pyrimidine-specific mismatch base pair DNA N-glycosylase activity",
"DNA repair"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF"
] | [
"PIRSF038005"
] | [
"Methyl_CpG_bd_MBD4"
] | [
492
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110357",
"R-MMU-110329",
"R-MMU-110357"
] | [
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110357",
"REACTOME:R-MMU-110329",
"REACTOME:R-MMU-110357"
] | 5 | [] | 0 | [
"PUB00046572",
"PUB00073665"
] | [
"9774669",
"10930409"
] | [
"Identification and characterization of a family of mammalian methyl-CpG binding proteins.",
"Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase."
] | [
1998,
2000
] | 2 | [
"IPR045138"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
492
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4
] | 3 | true | Family | Methyl-CpG-binding domain protein 4 | Methyl-CpG-binding domain protein 4 | MBD4 | 8 |
IPR017353 | 17,353 | Methyl-CpG binding protein MeCP2 | Me_CpG-bd_MeCP2 | Family | 312 | false | false | Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [ , ]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifica... | [
"GO:0010385",
"GO:0000122",
"GO:0005634"
] | [
"double-stranded methylated DNA binding",
"negative regulation of transcription by RNA polymerase II",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF038006"
] | [
"Methyl_CpG_bd_MeCP2"
] | [
312
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8986944",
"R-HSA-9022534",
"R-HSA-9022535",
"R-HSA-9022537",
"R-HSA-9022538",
"R-HSA-9022692",
"R-HSA-9022699",
"R-HSA-9022702",
"R-HSA-9022707",
"R-HSA-9022927",
"R-HSA-9725371",
"R-MMU-9022692",
"R-RNO-9022692"
] | [
"REACTOME:R-HSA-8986944",
"REACTOME:R-HSA-9022534",
"REACTOME:R-HSA-9022535",
"REACTOME:R-HSA-9022537",
"REACTOME:R-HSA-9022538",
"REACTOME:R-HSA-9022692",
"REACTOME:R-HSA-9022699",
"REACTOME:R-HSA-9022702",
"REACTOME:R-HSA-9022707",
"REACTOME:R-HSA-9022927",
"REACTOME:R-HSA-9725371",
"REACTOM... | 13 | [] | 0 | [
"PUB00015391",
"PUB00015393",
"PUB00046573",
"PUB00073628",
"PUB00073629",
"PUB00073630",
"PUB00073631",
"PUB00073632"
] | [
"12787239",
"12529184",
"9620804",
"25527496",
"9620779",
"25165434",
"25227661",
"11738839"
] | [
"Characterization of Arabidopsis thaliana methyl-CpG-binding domain (MBD) proteins.",
"Comparative study of methyl-CpG-binding domain proteins.",
"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.",
"The methyl-CpG binding protein 2 (MeCP2) localizes at... | [
2003,
2003,
1998,
2014,
1998,
2014,
2014,
2001
] | 8 | [
"IPR045138"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
312
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
10,
1,
4
] | 4 | true | Family | Methyl-CpG binding protein MeCP2 | Methyl-CpG binding protein MeCP2 | Me_CpG-bd_MeCP2 | 1 |
IPR017354 | 17,354 | Vasodilator-stimulated phosphoprotein/ENA/VASP-like | VASP/EVL | Family | 1,387 | false | false | Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity, such as axon guidance and lamellipodial and filopodial dynamics in migrating cells [ , ]. Ena/VASP proteins possess a modular domain organization, including a conserved tetramerizatio... | [
"GO:0003779",
"GO:0017124",
"GO:0008154",
"GO:0051289",
"GO:0005856"
] | [
"actin binding",
"SH3 domain binding",
"actin polymerization or depolymerization",
"protein homotetramerization",
"cytoskeleton"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PIRSF"
] | [
"PIRSF038010"
] | [
"Vasodilator_Phospo"
] | [
1387
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-446353",
"R-DDI-5658442",
"R-HSA-202433",
"R-HSA-376176",
"R-HSA-446353",
"R-HSA-5663220",
"R-MMU-376176",
"R-MMU-446353",
"R-MMU-5663220",
"R-RNO-5663220"
] | [
"REACTOME:R-DDI-446353",
"REACTOME:R-DDI-5658442",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-376176",
"REACTOME:R-HSA-446353",
"REACTOME:R-HSA-5663220",
"REACTOME:R-MMU-376176",
"REACTOME:R-MMU-446353",
"REACTOME:R-MMU-5663220",
"REACTOME:R-RNO-5663220"
] | 10 | [] | 0 | [
"PUB00018221",
"PUB00083357",
"PUB00083359"
] | [
"14570581",
"11295557",
"26221026"
] | [
"Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration.",
"Actin-based motility: stop and go with Ena/VASP proteins.",
"Selectivity in subunit composition of Ena/VASP tetramers."
] | [
2003,
2001,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1387
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
6,
6,
16
] | 4 | true | Family | Vasodilator-stimulated phosphoprotein/ENA/VASP-like | Vasodilator-stimulated phosphoprotein/ENA/VASP-like | VASP/EVL | 8 |
IPR017355 | 17,355 | Tumour necrosis factor ligand 10/11 | TNF_ligand_10/11 | Family | 1,642 | false | false | This group represents a tumour necrosis factor ligand superfamily member, 10/11 types. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF038013"
] | [
"TNF10_TNF11"
] | [
1642
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140534",
"R-HSA-3371378",
"R-HSA-5213460",
"R-HSA-5218900",
"R-HSA-5668541",
"R-HSA-5669034",
"R-HSA-5676594",
"R-HSA-69416",
"R-HSA-75158",
"R-HSA-9856649",
"R-MMU-3371378",
"R-MMU-5218900",
"R-MMU-5668541",
"R-MMU-5669034",
"R-MMU-5676594",
"R-MMU-69416",
"R-MMU-75158",
"R... | [
"REACTOME:R-HSA-140534",
"REACTOME:R-HSA-3371378",
"REACTOME:R-HSA-5213460",
"REACTOME:R-HSA-5218900",
"REACTOME:R-HSA-5668541",
"REACTOME:R-HSA-5669034",
"REACTOME:R-HSA-5676594",
"REACTOME:R-HSA-69416",
"REACTOME:R-HSA-75158",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-3371378",
"REACTOME:R-M... | 22 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chordata",
"Pteropox virus"
] | [
1641,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
7,
10
] | 4 | true | Family | Tumour necrosis factor ligand 10/11 | Tumour necrosis factor ligand 10/11 | TNF_ligand_10/11 | 4 |
IPR017356 | 17,356 | Chimaerin | CHN1/CHN2 | Family | 1,564 | false | false | Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer [ ]. This entry includes alpha-chimaerin (Chn1) and beta-chimaerin (Chn2) from animals. | [
"GO:0005096",
"GO:0051056"
] | [
"GTPase activator activity",
"regulation of small GTPase mediated signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF038015"
] | [
"N-chimaerin"
] | [
1564
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013148",
"R-HSA-9013149",
"R-MMU-9013148",
"R-MMU-9013149"
] | [
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-MMU-9013148",
"REACTOME:R-MMU-9013149"
] | 4 | [
"1xa6",
"3cxl"
] | 2 | [
"PUB00032364",
"PUB00073311",
"PUB00077022",
"PUB00077023"
] | [
"15507211",
"17785183",
"23673634",
"22726444"
] | [
"Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin.",
"alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.",
"Coordinated activation of the Rac-GAP β2-chimaerin by an atypical proline-rich domain and diacylglycerol.",
"The RacGAP β2-... | [
2004,
2007,
2013,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1564
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
8,
2,
7
] | 6 | true | Family | Chimaerin | Chimaerin | CHN1/CHN2 | 5 |
IPR017357 | 17,357 | Telomeric repeat-binding factor 1/2 | TERF1/2 | Family | 1,332 | false | false | This group represents telomeric repeat-binding factors 1 (TERF1, also known as TRF1). Telomeres function to shield chromosome ends from degradation and end-to-end fusions, as well as preventing the activation of DNA damage checkpoints. Telomeric repeat binding factor (TRF) proteins TRF1 and TRF2 are major components of... | [
"GO:0042162",
"GO:0000723",
"GO:0000781",
"GO:0005634"
] | [
"telomeric DNA binding",
"telomere maintenance",
"chromosome, telomeric region",
"nucleus"
] | [
"molecular_function",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF038016"
] | [
"Telomere_bd-1_Pin2"
] | [
1332
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-1221632",
"R-HSA-171306",
"R-HSA-171319",
"R-HSA-174411",
"R-HSA-174414",
"R-HSA-174417",
"R-HSA-174430",
"R-HSA-174437",
"R-HSA-2559586",
"R-HSA-9670095",
"R-MMU-110330",
"R-MMU-110331",
"R-MMU-171319",
"R-MMU-... | [
"REACTOME:R-HSA-110328",
"REACTOME:R-HSA-110329",
"REACTOME:R-HSA-110330",
"REACTOME:R-HSA-110331",
"REACTOME:R-HSA-1221632",
"REACTOME:R-HSA-171306",
"REACTOME:R-HSA-171319",
"REACTOME:R-HSA-174411",
"REACTOME:R-HSA-174414",
"REACTOME:R-HSA-174417",
"REACTOME:R-HSA-174430",
"REACTOME:R-HSA-17... | 24 | [
"8ox1",
"9q9m"
] | 2 | [
"PUB00013264",
"PUB00033335",
"PUB00033336"
] | [
"11545737",
"15316005",
"9034194"
] | [
"Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.",
"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.",
"Regulation of telomere length and function by a Myb-domain protein in fission yeast."
] | [
2001,
2004,
1997
] | 3 | [] | [
"IPR030657"
] | 0 | 1 | 0 | [
"Bilateria"
] | [
1332
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
8,
5,
5
] | 4 | true | Family | Telomeric repeat-binding factor 1/2 | Telomeric repeat-binding factor 1/2 | TERF1/2 | 5 |
IPR017358 | 17,358 | Ras-related small G protein, RGK family | RGK | Family | 2,241 | false | false | This entry includes Rad, Rem, and Gem/Kir. They belong to the Ras superfamily of monomeric G-proteins. They are the most potent known intracellular inhibitors of high-voltage-activated Ca2+(Ca(V)1 and Ca(V)2) channels [ ]. Similar to other Ras superfamily proteins, RGKs contain a guanine nucleotide binding domain (G-do... | [
"GO:1901842"
] | [
"negative regulation of high voltage-gated calcium channel activity"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF038017"
] | [
"GTP-binding_GEM"
] | [
2241
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9031628",
"R-HSA-9768919"
] | [
"REACTOME:R-HSA-9031628",
"REACTOME:R-HSA-9768919"
] | 2 | [] | 0 | [
"PUB00085110"
] | [
"23063948"
] | [
"Regulation of voltage-dependent calcium channels by RGK proteins."
] | [
2013
] | 1 | [
"IPR001806"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
2241
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
6,
6,
7
] | 5 | true | Family | Ras-related small G protein, RGK family | Ras-related small G protein, RGK family | RGK | 2 |
IPR017359 | 17,359 | Phomoidride biosynthesis cluster protein F-like | Phi-like | Family | 3,582 | false | false | This entry represents a family of animal and fungal proteins, including Phomoidride biosynthesis cluster protein F (PhiF), part of the gene cluster that mediates the biosynthesis of the antihypercholesterolemic agents phomoidrides which are dimeric anhydrides [ ]. Many members of this group have a N-terminal RWD domain... | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF038021",
"PTHR15955"
] | [
"UCP038021_RWDD2",
""
] | [
2416,
3582
] | 2 | [
"REACTOME"
] | [
"R-MMU-3065678"
] | [
"REACTOME:R-MMU-3065678"
] | 1 | [
"2daw",
"2dax"
] | 2 | [
"PUB00152818"
] | [
"26558485"
] | [
"Biosynthetic Study on Antihypercholesterolemic Agent Phomoidride: General Biogenesis of Fungal Dimeric Anhydrides."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3582
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
5,
3,
6
] | 5 | true | Family | Phomoidride biosynthesis cluster protein F-like | Phomoidride biosynthesis cluster protein F-like | Phi-like | 3 |
IPR017361 | 17,361 | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | Bifunc_PIno_P3_Pase/Pase_PTEN | Family | 1,319 | false | false | This entry represents the magnesium-dependent bifunctional phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase/dual-specificity protein phosphatase PTEN ( ; ; ), which possesses the following catalytic activities: Phosphatidylinositol 3,4,5-trisphosphate + H(2)O = phosphatidylinositol 4,5-bisphosphate + phosphate. A... | [
"GO:0016314",
"GO:0051717",
"GO:0051800",
"GO:0008285",
"GO:0046856"
] | [
"phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity",
"inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity",
"phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity",
"negative regulation of cell population proliferation",
"phosphatidylinositol dephosphorylation"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 5 | [
"PIRSF"
] | [
"PIRSF038025"
] | [
"PTEN"
] | [
1319
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
... | [
"3.1.3.-",
"3.1.3.16",
"3.1.3.48",
"3.1.3.67",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119... | [
"EC:3.1.3.-",
"EC:3.1.3.16",
"EC:3.1.3.48",
"EC:3.1.3.67",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACY... | 67 | [
"7jtx",
"7juk",
"7jul",
"7jvx"
] | 4 | [
"PUB00044639",
"PUB00044640",
"PUB00044641"
] | [
"17324556",
"18794879",
"18838554"
] | [
"PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation.",
"PTEN: a new guardian of the genome.",
"Akt inhibition promotes autopha... | [
2007,
2008,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1319
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
1,
12,
5,
3
] | 5 | true | Family | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | Bifunc_PIno_P3_Pase/Pase_PTEN | 2 |
IPR017362 | 17,362 | DNA-binding, RFXANK | DNA-bd_RFXANK | Family | 372 | false | false | This group represents the DNA-binding protein RFXANK which activates transcription from class II MHC promoters, requiring the activity of the MHC class II transactivator/CIITA. Deficiency is the commonest cause of bare lymphocyte syndrome (the absence of MHC class II transcription and humoral- and cellular-mediated imm... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF038034"
] | [
"DNA-binding_RFXANK"
] | [
372
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070258",
"PUB00079375"
] | [
"10072068",
"9806546"
] | [
"RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.",
"A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients."
] | [
1999,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
372
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
2
] | 3 | true | Family | DNA-binding, RFXANK | DNA-binding, RFXANK | DNA-bd_RFXANK | 6 |
IPR017363 | 17,363 | Cdc42 effector protein 2 | Cdc42_effector_prot_2 | Family | 168 | false | false | This entry represents Cdc42 effector protein 2 (also known as Binder of Rho GTPases 1). It is probably involved in the organisation of the actin cytoskeleton [ , ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF038036"
] | [
"Cdc42_effector_p2"
] | [
168
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5687128",
"R-BTA-9013406",
"R-HSA-5687128",
"R-HSA-9013148",
"R-HSA-9013406",
"R-MMU-5687128",
"R-MMU-9013406",
"R-RNO-5687128",
"R-RNO-9013406"
] | [
"REACTOME:R-BTA-5687128",
"REACTOME:R-BTA-9013406",
"REACTOME:R-HSA-5687128",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013406",
"REACTOME:R-MMU-5687128",
"REACTOME:R-MMU-9013406",
"REACTOME:R-RNO-5687128",
"REACTOME:R-RNO-9013406"
] | 9 | [] | 0 | [
"PUB00069960",
"PUB00069961"
] | [
"11035016",
"10490598"
] | [
"A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.",
"The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins."
] | [
2001,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
168
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2
] | 3 | true | Family | Cdc42 effector protein 2 | Cdc42 effector protein 2 | Cdc42_effector_prot_2 | 9 |
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