LiteFold/InterPro · Datasets at Hugging Face

IPR017130

17,130

Cholesteryl ester transfer

Cholesteryl_ester_transfer

Family

872

false

This group represents cholesteryl ester transfer protein, also known as lipid transfer protein 1. This protein shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Thus, inhibtion o...

[ "GO:0120020", "GO:0043691", "GO:0034364" ]

[ "cholesterol transfer activity", "reverse cholesterol transport", "high-density lipoprotein particle" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF037185", "PTHR47616" ]

[ "Cholesteryl_ester_transf", "" ]

[ 740, 872 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8964041", "R-HSA-8964058", "R-HSA-9029569" ]

[ "REACTOME:R-HSA-8964041", "REACTOME:R-HSA-8964058", "REACTOME:R-HSA-9029569" ]

3

[ "2obd", "4ews", "4f2a" ]

3

[ "PUB00042145" ]

[ "17237796" ]

[ "Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules." ]

[ 2007 ]

1

[]

0

null

[ "Vertebrata" ]

[ 872 ]

1

[ "Danio rerio", "Homo sapiens" ]

[ 1, 7 ]

2

true

Family

Cholesteryl ester transfer

Cholesteryl_ester_transfer

1

IPR017131

17,131

Small ribonucleoprotein associated, SmB/SmN

snRNP-assoc_SmB/SmN

Family

2,037

false

This entry represents a group of small nuclear ribonucleoprotein associated proteins from animals and plants, including SmB and SmN. Human SmB plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome [ ,...

[]

0

[ "PIRSF" ]

[ "PIRSF037187" ]

[ "snRNP_SmB/SmN" ]

[ 2037 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111367", "R-BTA-191859", "R-BTA-72163", "R-BTA-72165", "R-BTA-73856", "R-BTA-77588", "R-DME-111367", "R-DME-72163", "R-DME-72165", "R-DME-73856", "R-DME-77588", "R-GGA-111367", "R-GGA-191859", "R-GGA-72163", "R-GGA-72165", "R-GGA-73856", "R-GGA-77588", "R-HSA-111367", "R-H...

[ "REACTOME:R-BTA-111367", "REACTOME:R-BTA-191859", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-77588", "REACTOME:R-DME-111367", "REACTOME:R-DME-72163", "REACTOME:R-DME-72165", "REACTOME:R-DME-73856", "REACTOME:R-DME-77588", "REACTOME:R-GGA-111367", ...

36

[ "3jcr", "3pgw", "5mqf", "5o9z", "5xjc", "5yzg", "5z56", "5z57", "5z58", "6ah0", "6ahd", "6ff7", "6icz", "6id0", "6id1", "6qw6", "6qx9", "6y53", "6y5q", "7a5p", "7abg", "7abi", "7b0y", "7dvq", "7evo", "7qtt", "7vpx", "7w59", "7w5a", "7w5b", "8c6j", "8ch6"...

67

[ "PUB00090272", "PUB00092514", "PUB00097019", "PUB00100665", "PUB00103470", "PUB00103471", "PUB00103472", "PUB00103473" ]

[ "28781166", "28502770", "28076346", "26912367", "25047197", "25555158", "1303277", "25504470" ]

[ "Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.", "An Atomic Structure of the Human Spliceosome.", "Cryo-EM structure of a human spliceosome activated for step 2 of splicing.", "Molecular architecture of the human U4/U6.U5 tri-snRNP.", "Disrupted auto-regulation of the spliceo...

[ 2017, 2017, 2017, 2016, 2014, 2015, 1992, 2015 ]

8

[]

0

null

[ "Eukaryota" ]

[ 2037 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 1, 10, 4, 1, 6, 4 ]

8

true

Family

Small ribonucleoprotein associated, SmB/SmN

snRNP-assoc_SmB/SmN

4

IPR017132

17,132

Sm-like protein Lsm7

Lsm7

Family

3,962

false

This entry represents Sm-like protein Lsm7. It could be found in the nuclear Lsm2-8 complex or in the cytoplasmic Lsm1-7 complex. The Lsm2-8 complex associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 snRNP, U4/U6.U5 snRNP, and free U6 snRNP). It binds and stabilizes the 3'-terminal poly(U) tract of...

[ "GO:0000398", "GO:0000956" ]

[ "mRNA splicing, via spliceosome", "nuclear-transcribed mRNA catabolic process" ]

[ "biological_process", "biological_process" ]

2

[ "CDD" ]

[ "cd01729" ]

[ "LSm7" ]

[ 3962 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-430039", "R-DRE-430039", "R-HSA-430039", "R-HSA-72163", "R-MMU-430039", "R-MMU-72163", "R-SCE-430039", "R-SPO-430039" ]

[ "REACTOME:R-DDI-430039", "REACTOME:R-DRE-430039", "REACTOME:R-HSA-430039", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-430039", "REACTOME:R-MMU-72163", "REACTOME:R-SCE-430039", "REACTOME:R-SPO-430039" ]

8

[ "3jcm", "3jcr", "3swn", "4c8q", "4c92", "4emk", "4m75", "4m77", "4m78", "4m7a", "4m7d", "5gan", "5nrl", "5o9z", "5vsu", "5zwm", "5zwo", "6ah0", "6ahd", "6aso", "6ppn", "6ppp", "6ppq", "6ppv", "6qw6", "6qx9", "7abg", "8h6e", "8h6j", "8h6k", "8h6l", "8qo9"...

39

[ "PUB00016606", "PUB00063326", "PUB00065876", "PUB00073458", "PUB00082657" ]

[ "10801455", "15916535", "22615807", "24240276", "24513854" ]

[ "Functions of Lsm proteins in mRNA degradation and splicing.", "Lsm proteins and RNA processing.", "Crystal structures of Lsm3, Lsm4 and Lsm5/6/7 from Schizosaccharomyces pombe.", "Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.", "Crystal structure and biochemica...

[ 2000, 2005, 2012, 2014, 2014 ]

5

[ "IPR044641" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3962 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 1, 8, 2, 1, 1, 2, 3, 1, 1, 5 ]

12

true

Family

Sm-like protein Lsm7

Lsm7

2

IPR017133

17,133

L-tyrosine isonitrile synthase

PvcA

Family

485

false

This protein family represents L-tyrosine isonitrile synthase (PvcA), which is involved in the biosynthesis of paerucumarin, a cyclized isocyano derivative of tyrosine [ , ].

[]

0

[ "PIRSF" ]

[ "PIRSF037196" ]

[ "Pyoverdine_chromoph_PvcA" ]

[ 485 ]

1

[]

0

[ "3e59", "9dh4", "9dhm", "9dhn" ]

4

[ "PUB00051594", "PUB00100358" ]

[ "18824174", "18689486" ]

[ "Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.", "Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa." ]

[ 2008, 2008 ]

2

[ "IPR007817" ]

[]

1

0

1

[ "Bacteria" ]

[ 485 ]

1

[]

0

true

Family

L-tyrosine isonitrile synthase

PvcA

8

IPR017134

17,134

Ubiquitin-protein ligase E3A

UBE3A

Family

1,235

false

UBE3A (also known as E6-AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. It regulates cell proliferation by promoting proteasomal degradation of p27 [ ]. It can also serve as a molecular circadian clock t...

[ "GO:0061630", "GO:0006511" ]

[ "ubiquitin protein ligase activity", "ubiquitin-dependent protein catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037201" ]

[ "Ubiquitin-protein_ligase_E6-AP" ]

[ 1235 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

2

[ "8gcr", "8jrn", "8jro", "8jrp", "8jrq", "8jrr", "8r1f", "8r1g", "9cht" ]

9

[ "PUB00078795", "PUB00078796" ]

[ "19591933", "24728990" ]

[ "UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.", "The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor." ]

[ 2009, 2014 ]

2

[]

0

null

[ "Bilateria" ]

[ 1235 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 6, 2, 3 ]

5

true

Family

Ubiquitin-protein ligase E3A

UBE3A

1

IPR017135

17,135

D-glutamate cyclase, mitochondrial

D-Glu_cyclase_mito

Family

593

false

This family includes mitochondrial D-glutamate cyclase ( ), which converts D-glutamate to 5-oxo-D-proline [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF037204" ]

[ "UCP037204" ]

[ 593 ]

1

[]

0

[]

0

[ "PUB00086027" ]

[ "28266638" ]

[ "D-Glutamate is metabolized in the heart mitochondria." ]

[ 2017 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 593 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 5 ]

3

true

Family

D-glutamate cyclase, mitochondrial

D-Glu_cyclase_mito

7

IPR017136

17,136

Uncharacterised conserved protein UCP037205

UCP037205

Family

3,820

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF10013", "PIRSF037205", "PTHR37463" ]

[ "DUF2256", "UCP037205", "" ]

[ 3819, 2320, 3630 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3586, 219, 15 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP037205

UCP037205

5

IPR017137

17,137

Arginine-tRNA-protein transferase 1, eukaryotic

Arg-tRNA-P_Trfase_1_euk

Family

4,143

false

Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the...

[ "GO:0004057", "GO:0016598" ]

[ "arginyl-tRNA--protein transferase activity", "protein arginylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037207" ]

[ "ATE1_euk" ]

[ 4143 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.8", "PWY-7799" ]

[ "EC:2.3.2.8", "METACYC:PWY-7799" ]

2

[ "8tzv", "8uau" ]

2

[ "PUB00009970", "PUB00009971", "PUB00044650" ]

[ "9858543", "7495814", "16002466" ]

[ "Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway.", "Binding of phenylarsenoxide to Arg-tRNA protein transferase is independent of vicinal thiols.", "Identification of mammalian arginy...

[ 1999, 1995, 2005 ]

3

[ "IPR030700" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4143 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 12, 5, 15, 2, 28, 5, 2, 8, 9 ]

9

true

Family

Arginine-tRNA-protein transferase 1, eukaryotic

Arg-tRNA-P_Trfase_1_euk

2

IPR017138

17,138

Aspartate/glutamate leucyltransferase

Asp_Glu_LeuTrfase

Family

7,721

false

This entry represents a family of prokaryotic aminoacyl-transferases, specifically aspartate/glutamate leucyltransferase. Aspartate/glutamate leucyltransferase (also known as bacterial protein transferase or Bpt) functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA ...

[ "GO:0008914", "GO:0071596" ]

[ "leucyl-tRNA--protein transferase activity", "ubiquitin-dependent protein catabolic process via the N-end rule pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF" ]

[ "MF_00689", "PIRSF037208" ]

[ "Bpt", "ATE_pro_prd" ]

[ 7505, 7598 ]

2

[ "EC", "METACYC" ]

[ "2.3.2.29", "PWY-7802" ]

[ "EC:2.3.2.29", "METACYC:PWY-7802" ]

2

[]

0

[ "PUB00088202" ]

[ "16492767" ]

[ "Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen." ]

[ 2006 ]

1

[ "IPR030700" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7613, 12, 96 ]

3

[]

0

true

Family

Aspartate/glutamate leucyltransferase

Asp_Glu_LeuTrfase

3

IPR017139

17,139

Uncharacterised conserved protein UCP037213

UCP037213

Family

64

false

There is currently no experimental data for members of this family of archaeal proteins, nor do they exhibit features indicative of any function.

[]

0

[ "PIRSF" ]

[ "PIRSF037213" ]

[ "UCP037213" ]

[ 64 ]

1

[]

0

[]

0

[]

0

[ "IPR019254" ]

[]

1

0

1

[ "Archaea" ]

[ 64 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP037213

UCP037213

6

IPR017140

17,140

ThermoDBP-related, archaea

ThermoDBP-RPs_arc

Domain

175

false

This entry represents a group of proteins related to archaeal non-canonical single-stranded DNA-binding proteins (ThermoDBPs) named ThermoDBP-related proteins. These proteins have been related to genome maintenance in particularly challenging environments, but their specific function is still unknown [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10015", "PIRSF037214" ]

[ "ThermoDBP-RP_arch", "UCP037214" ]

[ 175, 49 ]

2

[]

0

[ "4psl", "4psm", "4psn", "4pso" ]

4

[ "PUB00100849" ]

[ "24744237" ]

[ "Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein." ]

[ 2014 ]

1

[]

0

null

[ "Archaea" ]

[ 175 ]

1

[]

0

true

Domain

ThermoDBP-related, archaea

ThermoDBP-RPs_arc

3

IPR017141

17,141

Peptidase M20, carboxypeptidase S

Pept_M20_carboxypep

Family

2,747

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004181" ]

[ "metallocarboxypeptidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037217" ]

[ "Carboxypeptidase_S" ]

[ 2747 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9673163", "R-SCE-9673163", "R-SPO-9673163" ]

[ "REACTOME:R-DRE-9673163", "REACTOME:R-SCE-9673163", "REACTOME:R-SPO-9673163" ]

3

[]

0

[ "PUB00003579", "PUB00085108" ]

[ "7674922", "2026161" ]

[ "Evolutionary families of metallopeptidases.", "Carboxypeptidase yscS: gene structure and function of the vacuolar enzyme." ]

[ 1995, 1991 ]

2

[ "IPR047177" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "mine drainage metagenome" ]

[ 10, 2736, 1 ]

3

[ "Danio rerio", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1, 2, 1 ]

4

true

Family

Peptidase M20, carboxypeptidase S

Pept_M20_carboxypep

3

IPR017143

17,143

Uncharacterised conserved protein UCP037225

UCP037225

Family

2,662

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF037225" ]

[ "UCP037225" ]

[ 2662 ]

1

[]

0

[]

0

[]

0

[ "IPR025990" ]

[]

1

0

1

[ "Bacteria", "unclassified sequences" ]

[ 2630, 32 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP037225

UCP037225

6

IPR017144

17,144

Xaa-Arg dipeptidase

Xaa-Arg_dipeptidase

Family

9,476

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0016805" ]

[ "dipeptidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037226" ]

[ "Amidohydrolase_ACY1L2_prd" ]

[ 9476 ]

1

[]

0

[ "3ram", "7yh4", "8xzc", "8zei", "8zel" ]

5

[ "PUB00003579", "PUB00099558" ]

[ "7674922", "24891507" ]

[ "Evolutionary families of metallopeptidases.", "Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase." ]

[ 1995, 2014 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 56, 5326, 3985, 109 ]

4

[ "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 2, 1 ]

4

true

Family

Xaa-Arg dipeptidase

Xaa-Arg_dipeptidase

9

IPR017145

17,145

Aminobenzoyl-glutamate utilization protein B

Aminobenzoyl-glu_utiliz_pB

Family

3,771

false

This entry contains proteins that are related to glutamate carboxypeptidase and classed as non-peptidase homologues belonging to MEROPS peptidase family M20 (glutamate carboxypeptidase, clan MH) [ ]. The bacterial amidohydrolase abgB catalyses the cleavage of p-aminobenzoyl-glutamate, a folate catabolite in Escherichia...

[]

0

[ "PIRSF" ]

[ "PIRSF037227" ]

[ "Aminobenzoyl-glu_utiliz_pB" ]

[ 3771 ]

1

[ "GP" ]

[ "GenProp1119" ]

[ "GP:GenProp1119" ]

1

[]

0

[ "PUB00003579", "PUB00033912", "PUB00060288" ]

[ "7674922", "9829935", "17307853" ]

[ "Evolutionary families of metallopeptidases.", "Characterization of mutations that allow p-aminobenzoyl-glutamate utilization by Escherichia coli.", "Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate." ]

[ 1995, 1998, 2007 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "metagenomes" ]

[ 78, 3644, 2, 47 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Aminobenzoyl-glutamate utilization protein B

Aminobenzoyl-glu_utiliz_pB

8

IPR017147

17,147

Tricalbin

Family

1,875

false

Tricalbins constitute a synaptotagmin-like yeast protein family. Tricalbins contain several copies of C2 domains and are thought to be involved in membrane traffic [ , , ]. As extended synaptotagmins, tricalbins also possess a synaptotagmin-like mitochondrial lipid-binding protein (SMP) domain that is found in proteins...

[ "GO:0061817" ]

[ "endoplasmic reticulum-plasma membrane tethering" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF037232" ]

[ "Tricalbin" ]

[ 1875 ]

1

[]

0

[]

0

[ "PUB00074935", "PUB00074936", "PUB00074939", "PUB00087563", "PUB00087567", "PUB00087578" ]

[ "15049706", "17510957", "15141306", "28363589", "23791178", "23237950" ]

[ "The tricalbin C2 domains: lipid-binding properties of a novel, synaptotagmin-like yeast protein family.", "Beta-strand recombination in tricalbin evolution and the origin of synaptotagmin-like C2 domains.", "Characterization of the yeast tricalbins: membrane-bound multi-C2-domain proteins that form complexes i...

[ 2004, 2007, 2004, 2017, 2013, 2012 ]

6

[]

0

null

[ "Eukaryota" ]

[ 1875 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 2 ]

3

true

Family

Tricalbin

7

IPR017148

17,148

Vacuolar protein sorting-associated protein 13, fungi

VPS13_fungi

Family

1,151

false

This group represents a vacuolar protein sorting-associated protein Vps13, fungal type. It is involved in the delivery of proteins to the vacuole in vegetatively growing yeast [ ] and also regulates membrane morphogenesis during sporulation [ ]. Mediates the transfer of lipids between membranes at organelle contact sit...

[]

0

[ "PIRSF" ]

[ "PIRSF037235" ]

[ "VPS13_fungi" ]

[ 1151 ]

1

[]

0

[]

0

[ "PUB00061935", "PUB00061936", "PUB00100709", "PUB00100726", "PUB00100767", "PUB00100769", "PUB00101953" ]

[ "9314526", "22442115", "24036347", "34830155", "32690699", "30093493", "35357422" ]

[ "SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals.", "VPS13 regulates membrane morphogenesis during sporulation in Saccharomyces cerevisiae.", "SPO71 encodes a developmental stage-specific ...

[ 1997, 2012, 2013, 2021, 2020, 2018, 2022 ]

7

[ "IPR026847" ]

[]

1

0

1

[ "Fungi" ]

[ 1151 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Family

Vacuolar protein sorting-associated protein 13, fungi

VPS13_fungi

3

IPR017149

17,149

Glutathione degradosome, Dug2

GSH_degradosome_Dug2

Family

1,600

false

Glutathione (GSH), the major low-molecular-weight thiol compound in most eukaryotic cells, is normally degraded through the gamma-glutamyl cycle initiated by the action of gamma-glutamyl transpeptidase. A novel pathway for the degradation of GSH that requires the participation of three previously uncharacterised genes ...

[ "GO:0006751" ]

[ "glutathione catabolic process" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF037237" ]

[ "Peptidase_WD_repeats_DUG2" ]

[ 1600 ]

1

[]

0

[]

0

[ "PUB00035950", "PUB00085123" ]

[ "17179087", "22277648" ]

[ "The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae.", "Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransfera...

[ 2007, 2012 ]

2

[ "IPR002933" ]

[]

1

0

1

[ "Fungi" ]

[ 1600 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Glutathione degradosome, Dug2

GSH_degradosome_Dug2

3

IPR017150

17,150

Peptidase M20, glutamate carboxypeptidase

Pept_M20_glutamate_carboxypep

Family

7,234

false

Glutamate carboxypeptidase (also known as carboxypeptidase G2, CPDG2, CPG2 or folate hydrolase G2) belongs to the peptidase M20 family. It is a periplasmic enzyme that is synthesized with a signal peptide. CPDG2 is a dimeric zinc-dependent exopeptidase, with two domains, a catalytic domain, which provides the ligands f...

[]

0

[ "PIRSF" ]

[ "PIRSF037238" ]

[ "Carboxypeptidase_G2" ]

[ 7234 ]

1

[]

0

[ "1cg2", "6xj5" ]

2

[ "PUB00015203", "PUB00079941", "PUB00079942", "PUB00079944" ]

[ "9083113", "15668713", "10090777", "11912146" ]

[ "Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy.", "Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure.", "Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.", "Three ...

[ 1997, 2005, 1999, 2002 ]

4

[ "IPR002933" ]

[]

1

0

1

[ "Bacteria", "Diploscapter pachys", "Methanobacteriati", "unclassified sequences" ]

[ 7030, 2, 22, 180 ]

4

[]

0

true

Family

Peptidase M20, glutamate carboxypeptidase

Pept_M20_glutamate_carboxypep

8

IPR017151

17,151

5'-3' exoribonuclease type 2

Xrn2/3/4

Family

5,652

false

5'-3'-exoribonucleases are enzymes that degrade RNA by removing terminal nucleotides from the 5' end. Hydrolytic exoribonucleases, to which this entry belongs, produce nucleotide monosphosphates. An exosome and a 5'-3'-exoribonuclease are important in the degradation of very unstable transcripts [ ]. This entry include...

[ "GO:0004534", "GO:0006139", "GO:0005634" ]

[ "5'-3' RNA exonuclease activity", "nucleobase-containing compound metabolic process", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037239" ]

[ "Exonuclease_Xrn2" ]

[ 5652 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.13.-", "R-GGA-6791226", "R-HSA-390471", "R-HSA-6791226", "R-HSA-9930044", "R-MMU-6791226", "R-SCE-450385", "R-SCE-450513" ]

[ "EC:3.1.13.-", "REACTOME:R-GGA-6791226", "REACTOME:R-HSA-390471", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-9930044", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-450385", "REACTOME:R-SCE-450513" ]

8

[ "3fqd", "5fir", "7opk", "8jch", "8k5p", "8q6v", "8qsz", "8yf5", "8yfe", "8yfq", "8yfr", "9dso", "9e70", "9exs", "9fms" ]

15

[ "PUB00043318", "PUB00063330", "PUB00073457" ]

[ "18481995", "20188675", "17993620" ]

[ "Control of mRNA degradation in trypanosomes.", "The yeast 5'-3' exonuclease Rat1p functions during transcription elongation by RNA polymerase II.", "Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors." ]

[ 2008, 2010, 2007 ]

3

[ "IPR027073" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5652 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 2, 1, 4, 1, 1, 13, 5, 1, 1, 26 ]

12

true

Family

5'-3' exoribonuclease type 2

Xrn2/3/4

6

IPR017153

17,153

Cytosolic nonspecific dipeptidase/DUG1

CNDP/DUG1

Family

3,504

false

This peptidase M20 subfamily includes CNDP1 (beta-Ala-His dipeptidase), CNDP2 (cytosolic nonspecific dipeptidase) and DUG1 from yeast, which are metallopeptidases [ , ]. Two genes, CN1 and CN2, that degrade carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyric acid-L-histidine), two naturally occurr...

[ "GO:0070573" ]

[ "metallodipeptidase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037242" ]

[ "CNDP_dipeptidase" ]

[ 3504 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.13", "R-BTA-174403", "R-BTA-9753281", "R-HSA-174403", "R-HSA-9753281", "R-MMU-174403", "R-MMU-9753281", "R-RNO-174403", "R-RNO-9753281", "R-SCE-174403", "R-SCE-9753281", "R-SPO-174403", "R-SPO-9753281" ]

[ "EC:3.4.13", "REACTOME:R-BTA-174403", "REACTOME:R-BTA-9753281", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-9753281", "REACTOME:R-MMU-174403", "REACTOME:R-MMU-9753281", "REACTOME:R-RNO-174403", "REACTOME:R-RNO-9753281", "REACTOME:R-SCE-174403", "REACTOME:R-SCE-9753281", "REACTOME:R-SPO-174403", ...

13

[ "2zof", "2zog", "3dlj", "4g1p", "4ruh" ]

5

[ "PUB00003579", "PUB00035950", "PUB00079870", "PUB00079893", "PUB00079945", "PUB00079946", "PUB00079947", "PUB00079953", "PUB00094410" ]

[ "7674922", "17179087", "10493853", "16722645", "17012794", "16181134", "16302965", "19346245", "12473676" ]

[ "Evolutionary families of metallopeptidases.", "The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae.", "The Zn-peptidase superfamily: functional convergence after evolutionary divergence.", "Homology modeling of human ...

[ 1995, 2007, 1999, 2006, 2006, 2005, 2005, 2009, 2003 ]

9

[ "IPR002933" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3504 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 2, 2, 6, 3, 1, 5, 1, 1 ]

9

true

Family

Cytosolic nonspecific dipeptidase/DUG1

CNDP/DUG1

2

IPR017154

17,154

PC4-like

Family

1,715

false

This family includes PC4-like proteins predominantly found in bacteria, such as SP_0782 from Streptococcus pneumoniae ( ). The crystal structure of this protein has similarity with PC4 and YdbC ( ), but it binds shorter ssDNA lengths. This protein adopts a dimeric assembly in which each monomer folds into an anti-paral...

[]

0

[ "PIRSF" ]

[ "PIRSF037246" ]

[ "UCP037246" ]

[ 1715 ]

1

[]

0

[ "2l3a", "2ltd", "2ltt", "3obh", "3pm7", "4g06", "5zkl", "5zkm", "6jip", "6jiq" ]

10

[ "PUB00100700" ]

[ "31713614" ]

[ "Structural insight into the length-dependent binding of ssDNA by SP_0782 from Streptococcus pneumoniae, reveals a divergence in the DNA-binding interface of PC4-like proteins." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriati", "metagenomes" ]

[ 1681, 13, 21 ]

3

[]

0

true

Family

PC4-like

2

IPR017155

17,155

Histone-lysine N-methyltransferase SETD7

Hist-Lys_N-MeTrfase_SETD7

Family

936

false

This entry represents histone-lysine N-methyltransferase SETD7 (also known as SET7/9) ( ), which contains a SET domain [ , ]. This enzyme specifically monomethylate Lys-4 of histone H3, thereby creating a specific tag for epigenetic transcriptional activation. Methylation of lysine residues in the N-terminal tails of h...

[ "GO:0016279", "GO:0140945", "GO:0006355", "GO:0005694" ]

[ "protein-lysine N-methyltransferase activity", "histone H3K4 monomethyltransferase activity", "regulation of DNA-templated transcription", "chromosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF", "PROFILE" ]

[ "PIRSF037249", "PS51577" ]

[ "Histone_Lys_mtfrase_SET", "SAM_MT43_SET7" ]

[ 359, 936 ]

2

[ "EC", "REACTOME", "REACTOME" ]

[ "2.1.1.364", "R-HSA-3214841", "R-MMU-3214841" ]

[ "EC:2.1.1.364", "REACTOME:R-HSA-3214841", "REACTOME:R-MMU-3214841" ]

3

[ "1h3i", "1mt6", "1muf", "1n6a", "1n6c", "1o9s", "1xqh", "2f69", "3cbm", "3cbo", "3cbp", "3m53", "3m54", "3m55", "3m56", "3m57", "3m58", "3m59", "3m5a", "3os5", "3vuz", "3vv0", "4e47", "4j7f", "4j7i", "4j83", "4j8o", "4jds", "4jlg", "5ayf", "5eg2", "5ylt"...

32

[ "PUB00018236", "PUB00027453", "PUB00027572", "PUB00032493", "PUB00040554", "PUB00044656", "PUB00103776" ]

[ "12372304", "12389038", "12514135", "15525938", "16415881", "18391193", "16141209" ]

[ "Crystal structure and functional analysis of the histone methyltransferase SET7/9.", "The active site of the SET domain is constructed on a knot.", "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.", "Regulation of p53 activity through lysine methylation.", "Structura...

[ 2002, 2002, 2003, 2004, 2006, 2008, 2005 ]

7

[]

0

null

[ "Eukaryota" ]

[ 936 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 3 ]

4

true

Family

Histone-lysine N-methyltransferase SETD7

Hist-Lys_N-MeTrfase_SETD7

4

IPR017156

17,156

Carboxysome assembly protein CcmM

CcmM

Family

300

false

This entry represents CcmM, which functions as a scaffold protein for the assembly of β-carboxysomes, initiates carboxysome assembly via its N-terminal domain binding to CcaA, CcmK and CcmL. Binds HCO3-, suggesting it may play a role in the activity or regulation of bicarbonate dehydration [ ]. Aquatic photosynthetic o...

[ "GO:0043886" ]

[ "structural constituent of carboxysome shell" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037250" ]

[ "CcmM" ]

[ 300 ]

1

[]

0

[]

0

[ "PUB00044056", "PUB00044057", "PUB00044058", "PUB00044059", "PUB00079641" ]

[ "14645730", "18405332", "12554704", "18258595", "17993516" ]

[ "Inorganic carbon limitation induces transcripts encoding components of the CO(2)-concentrating mechanism in Synechococcus sp. PCC7942 through a redox-independent pathway.", "Identification and characterization of two closely related beta-carbonic anhydrases from Chlamydomonas reinhardtii.", "CO2 concentrating ...

[ 2003, 2008, 2003, 2008, 2008 ]

5

[]

0

null

[ "Cyanophyceae" ]

[ 300 ]

1

[]

0

true

Family

Carboxysome assembly protein CcmM

CcmM

3

IPR017157

17,157

Arylacetamide deacetylase

Arylacetamide_deacetylase

Family

3,969

false

The lipase arylacetamide deacetylase is involved in the utilisation of triacylglycerol (TAG) for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte, as the process is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification [ ]. The enzyme competes wi...

[ "GO:0052689", "GO:0016020" ]

[ "carboxylic ester hydrolase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF037251" ]

[ "Arylacetamide_deacetylase" ]

[ 3969 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "3.1.1", "3.1.1.-", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", "PWY-7769", "PWY-7982", "PWY-8058", ...

[ "EC:3.1.1", "EC:3.1.1.-", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", "METACYC:PWY-7367", "METACYC:PWY-7521", ...

36

[]

0

[ "PUB00043516", "PUB00043517" ]

[ "14748713", "8063807" ]

[ "Synthesis and function of hepatic very-low-density lipoprotein.", "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase." ]

[ 2004, 1994 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 3969 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 10, 6, 6, 18 ]

5

true

Family

Arylacetamide deacetylase

Arylacetamide_deacetylase

8

IPR017158

17,158

Transcription regulator, CBS domain-containing, predicted

Tscrpt-reg_CBS-contain_prd

Family

676

false

This entry represents a family of predicted transcriptional regulators, which contain CBS domains.

[]

0

[ "PIRSF" ]

[ "PIRSF037253" ]

[ "HTH_CBS_prd" ]

[ 676 ]

1

[]

0

[]

0

[]

0

[ "IPR051257" ]

[]

1

0

1

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 636, 22, 18 ]

3

[]

0

true

Family

Transcription regulator, CBS domain-containing, predicted

Tscrpt-reg_CBS-contain_prd

9

IPR017159

17,159

Gremlin-1/2

Family

804

false

This entry includes Gremlin-1 and -2. Gremlin 1 (grem 1) is known for its antagonistic reaction with bone morphogenetic proteins (BMPs) in the TGF beta signalling pathway. Grem 1 acts as a cytokine that regulates embryonic morphogenesis via BMP family members [ , ].

[]

0

[ "PIRSF" ]

[ "PIRSF037254" ]

[ "Gremlin_precursor" ]

[ 804 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-201451", "R-HSA-9830674", "R-MMU-201451" ]

[ "REACTOME:R-HSA-201451", "REACTOME:R-HSA-9830674", "REACTOME:R-MMU-201451" ]

3

[]

0

[ "PUB00073669", "PUB00073670" ]

[ "15201225", "17522159" ]

[ "Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.", "Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis." ]

[ 2004, 2007 ]

2

[]

0

null

[ "Euteleostomi" ]

[ 804 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 4, 6 ]

4

true

Family

Gremlin-1/2

6

IPR017160

17,160

Uncharacterised conserved protein UCP037256

UCP037256

Family

602

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF037256" ]

[ "UCP037256" ]

[ 602 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 602 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP037256

UCP037256

2

IPR017162

17,162

Uncharacterised conserved protein UCP037266

UCP037266

Family

1,746

false

Members in this family are found in various hypothetical prokaryotic proteins. Their function is not clear. They contain a probable winged helix DNA-binding domain.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09904", "PIRSF037266" ]

[ "HTH_43", "UCP037266" ]

[ 1746, 1531 ]

2

[]

0

[ "3ke2" ]

1

[]

0

[]

0

null

[ "Bacteria", "Pseudomonas phage PaBG", "Steinernema glaseri", "marine sediment metagenome" ]

[ 1741, 2, 1, 2 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP037266

UCP037266

9

IPR017163

17,163

Phosphatidylinositol-4-phosphate 5-kinase, plant

PIno-4-P-5_kinase_pln

Family

4,180

false

This entry represents a group of plant-type phosphatidylinositol-4-phosphate 5-kinases (PIP5K; ), which play an essential role in coordinating plant growth, especially in response to environmental factors. This enzyme phosphorylates phosphatidylinositol-4-phosphate to produce phosphatidylinositol-4,5-bisphosphate as a ...

[ "GO:0005524", "GO:0016308" ]

[ "ATP binding", "1-phosphatidylinositol-4-phosphate 5-kinase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF037274" ]

[ "PIP5K_plant_prd" ]

[ 4180 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.1.68", "PWY-6351", "PWY-6352" ]

[ "EC:2.7.1.68", "METACYC:PWY-6351", "METACYC:PWY-6352" ]

3

[]

0

[ "PUB00044688", "PUB00044689" ]

[ "9753781", "17220200" ]

[ "A gene encoding phosphatidylinositol-4-phosphate 5-kinase is induced by water stress and abscisic acid in Arabidopsis thaliana.", "PIP5K9, an Arabidopsis phosphatidylinositol monophosphate kinase, interacts with a cytosolic invertase to negatively regulate sugar-mediated root growth." ]

[ 1998, 2007 ]

2

[ "IPR023610" ]

[]

1

0

1

[ "Viridiplantae" ]

[ 4180 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 18, 43 ]

3

true

Family

Phosphatidylinositol-4-phosphate 5-kinase, plant

PIno-4-P-5_kinase_pln

9

IPR017164

17,164

Wee1-like protein kinase

Wee1-like_protein_kinase

Family

2,291

false

This group represents a Wee1-like protein kinase ( ), which is a key regulator for G(2)-to-M progression. This enzyme phosphorylates Tyr15 on Cdc2 (cell division control protein 2) when Cdc2 is complexed to cyclin B1, which results in blocking the progression of cells into M phase [ ]. As such, it negatively regulates ...

[ "GO:0000287", "GO:0004715", "GO:0000278", "GO:0005634" ]

[ "magnesium ion binding", "non-membrane spanning protein tyrosine kinase activity", "mitotic cell cycle", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF037281" ]

[ "Wee1-like_protein_kinase" ]

[ 2291 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.2", "R-DME-156711", "R-DME-69202", "R-DME-69273", "R-DME-69478", "R-DME-69656", "R-DME-75035", "R-HSA-156711", "R-HSA-69202", "R-HSA-69273", "R-HSA-69478", "R-HSA-69656", "R-HSA-75035", "R-HSA-983231", "R-MMU-156711", "R-MMU-69202", "R-MMU-69273", "R-MMU-69478", "R-MMU-69...

[ "EC:2.7.10.2", "REACTOME:R-DME-156711", "REACTOME:R-DME-69202", "REACTOME:R-DME-69273", "REACTOME:R-DME-69478", "REACTOME:R-DME-69656", "REACTOME:R-DME-75035", "REACTOME:R-HSA-156711", "REACTOME:R-HSA-69202", "REACTOME:R-HSA-69273", "REACTOME:R-HSA-69478", "REACTOME:R-HSA-69656", "REACTOME:R...

26

[]

0

[ "PUB00042736", "PUB00044669", "PUB00044670" ]

[ "9016762", "18385244", "17480229" ]

[ "14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase.", "Human immunodeficiency virus type 1 Vpr binds to the N lobe of the Wee1 kinase domain and enhances kinase activity for CDC2.", "Cdc25 and Wee1: analogous opposites?" ]

[ 1997, 2008, 2007 ]

3

[ "IPR050339" ]

[]

1

0

1

[ "Metazoa" ]

[ 2291 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 4, 2, 8 ]

5

true

Family

Wee1-like protein kinase

Wee1-like_protein_kinase

1

IPR017166

17,166

Uncharacterised conserved protein UCP037290

UCP037290

Family

2,567

false

There is currently no experimental data for members of this group. They may be distantly related to the cell division inhibitor SulA ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF037290" ]

[ "UCP037290" ]

[ 2567 ]

1

[]

0

[]

0

[]

0

[ "IPR047610" ]

[]

1

0

1

[ "Pseudomonadota", "metagenomes" ]

[ 2547, 20 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP037290

UCP037290

3

IPR017167

17,167

Uncharacterised conserved protein UCP037291, glutaredoxin-related

UCP037291_glutaredoxin-rel

Family

220

false

This group represents a glutaredoxin-related protein, HI0926 type.

[]

0

[ "PIRSF" ]

[ "PIRSF037291" ]

[ "UCP037291_gluthr" ]

[ 220 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 220 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP037291, glutaredoxin-related

UCP037291_glutaredoxin-rel

5

IPR017168

17,168

CRH-like

CHR-like

Family

2,919

false

This entry represents the glycosidases CRH1, CRH2 and their homologues. These enzymes function as GPI-lipid anchored cell wall proteins (GPI-CWP) that are localised to sites of polarised growth, particularly chitin-rich areas [ ]. These proteins are found at the incipient bud site, as a ring at the bud neck as the bud ...

[ "GO:0016798", "GO:0071555", "GO:0005618" ]

[ "hydrolase activity, acting on glycosyl bonds", "cell wall organization", "cell wall" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037299" ]

[ "Glycosidase_CRH1_prd" ]

[ 2919 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.1.14", "PWY-6855", "PWY-6902", "PWY-7822" ]

[ "EC:3.2.1.14", "METACYC:PWY-6855", "METACYC:PWY-6902", "METACYC:PWY-7822" ]

4

[]

0

[ "PUB00044634" ]

[ "17302808" ]

[ "Crh1p and Crh2p are required for the cross-linking of chitin to beta(1-6)glucan in the Saccharomyces cerevisiae cell wall." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2919 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 4, 2 ]

2

true

Family

CRH-like

CHR-like

9

IPR017169

17,169

Anaphase-promoting complex subunit 4, metazoa

APC4_metazoa

Family

862

false

The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, there...

[ "GO:0030071", "GO:0031145", "GO:0005680" ]

[ "regulation of mitotic metaphase/anaphase transition", "anaphase-promoting complex-dependent catabolic process", "anaphase-promoting complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037303" ]

[ "APC4" ]

[ 862 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-141430", "R-HSA-174048", "R-HSA-174084", "R-HSA-174154", "R-HSA-174178", "R-HSA-174184", "R-HSA-176407", "R-HSA-176408", "R-HSA-176409", "R-HSA-176412", "R-HSA-179409", "R-HSA-2467813", "R-HSA-2559582", "R-HSA-68867", "R-HSA-69017", "R-HSA-8853884", "R-HSA-9687136", "R-HSA-9...

[ "REACTOME:R-HSA-141430", "REACTOME:R-HSA-174048", "REACTOME:R-HSA-174084", "REACTOME:R-HSA-174154", "REACTOME:R-HSA-174178", "REACTOME:R-HSA-174184", "REACTOME:R-HSA-176407", "REACTOME:R-HSA-176408", "REACTOME:R-HSA-176409", "REACTOME:R-HSA-176412", "REACTOME:R-HSA-179409", "REACTOME:R-HSA-246...

34

[ "4ui9", "5a31", "5bpt", "5bpw", "5g04", "5g05", "5khr", "5khu", "5l9t", "5l9u", "5lcw", "6q6g", "6q6h", "6tlj", "6tm5", "6tnt", "8pkp", "8tar", "8tau", "9gaw", "9n9r", "9n9s" ]

22

[ "PUB00059221" ]

[ "18485873" ]

[ "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex." ]

[ 2008 ]

1

[ "IPR024789" ]

[]

1

0

1

[ "Bilateria" ]

[ 862 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 3, 1, 3, 4 ]

5

true

Family

Anaphase-promoting complex subunit 4, metazoa

APC4_metazoa

7

IPR017170

17,170

Lhr-like ATP-dependent RNA helicase

Lhr-like

Family

6,556

false

This entry represents a family of Lhr-like ATP-dependent RNA helicases. Members include bacterial DEAD/DEAH box helicases found associated with a bacterial ATP-dependent DNA ligase, part of a four-gene system that occurs in about 12 % of prokaryotic reference genomes. Lhr is a DNA helicase that translocates in a 3'-to-...

[ "GO:0005524", "GO:0016818" ]

[ "ATP binding", "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF037307" ]

[ "Lhr-like_helic_prd" ]

[ 6556 ]

1

[ "EC" ]

[ "5.6.2.4" ]

[ "EC:5.6.2.4" ]

1

[ "5v9x" ]

1

[ "PUB00160772" ]

[ "32706021" ]

[ "Mechanistic insights into Lhr helicase function in DNA repair." ]

[ 2020 ]

1

[]

[ "IPR026362" ]

0

1

0

[ "Archaea", "Bacteria", "Russula earlei", "metagenomes" ]

[ 1439, 5078, 1, 38 ]

4

[]

0

true

Family

Lhr-like ATP-dependent RNA helicase

Lhr-like

6

IPR017171

17,171

Signal transduction histidine kinase, MctS

Sig_transdc_His_kinase_MctS

Family

1,760

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[]

0

[ "PIRSF" ]

[ "PIRSF037314" ]

[ "STHK_MctS" ]

[ 1760 ]

1

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[ "IPR050482" ]

[]

1

0

1

[ "Pseudomonadota", "metagenomes" ]

[ 1751, 9 ]

2

[]

0

true

Family

Signal transduction histidine kinase, MctS

Sig_transdc_His_kinase_MctS

4

IPR017172

17,172

Lipopolysaccharide core heptose(I) kinase RfaP

Lsacc_core_hep_kinase_RfaP

Family

2,002

false

This entry represents the lipopolysaccharide core heptose(I) kinase RfaP (also known as Lipopolysaccharide core heptose(I) kinase WaaP), which is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that RfaP is necess...

[ "GO:0016301", "GO:0009103" ]

[ "kinase activity", "lipopolysaccharide biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "PIRSF" ]

[ "NF011703", "PIRSF037318" ]

[ "PRK15123.1", "RfaP" ]

[ 2002, 1940 ]

2

[ "EC" ]

[ "2.7.1.235" ]

[ "EC:2.7.1.235" ]

1

[ "6dfl" ]

1

[ "PUB00005115", "PUB00010443", "PUB00015362", "PUB00020114", "PUB00034898", "PUB00034899" ]

[ "3291115", "11069912", "12368087", "12471243", "15078142", "15320712" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Purification and characterization of WaaP from Escherichia coli, a lipopolysaccharide kinase essential for outer membrane stability.", "Evolution of protein kinase signaling from yeast to man.", "The protein kina...

[ 1988, 2001, 2002, 2002, 2004, 2004 ]

6

[]

0

null

[ "Bacteria", "Candidatus Nitrosopumilus salarius BD31", "Eukaryota", "metagenomes" ]

[ 1985, 1, 3, 13 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipopolysaccharide core heptose(I) kinase RfaP

Lsacc_core_hep_kinase_RfaP

6

IPR017173

17,173

Nuclear mRNA export protein Sac3

Sac3

Family

153

false

This entry represents a mRNA export factor Sac3 from budding yeasts. Sac3 is a component of the TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p), which functions in transcription elongation and transcription-coupled mRNA export from the nucleus to the cytoplasm [ , , ]. Its N terminus associates with Thp1 and Sem1 to form an ...

[ "GO:0006406", "GO:0070390" ]

[ "mRNA export from nucleus", "transcription export complex 2" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF037320" ]

[ "mRNA_export_factor_Sac3" ]

[ 153 ]

1

[]

0

[ "5g5p", "5l3t" ]

2

[ "PUB00056186", "PUB00073512", "PUB00078005", "PUB00078008" ]

[ "12411502", "12702719", "18667528", "25294824" ]

[ "The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.", "Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism.", "The THP1-SAC3-SUS1-CDC31 complex works in transcription elongati...

[ 2002, 2003, 2008, 2014 ]

4

[ "IPR045107" ]

[]

1

0

1

[ "Dikarya" ]

[ 153 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Nuclear mRNA export protein Sac3

Sac3

7

IPR017174

17,174

Transcription factor TFIIIB component B'', fungi

Bdp1_fungi

Family

253

false

Transcription by RNA polymerase III (pol III) is a complex molecular process orchestrated by the two main transcription factors, TFIIIB and TFIIIC. The TFIIIB complex can be recruited by TFIIIC to upstream DNA and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic com...

[ "GO:0000995", "GO:0006383", "GO:0000126" ]

[ "RNA polymerase III general transcription initiation factor activity", "transcription by RNA polymerase III", "transcription factor TFIIIB complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037327" ]

[ "TFIIIB_Bdp1_fun" ]

[ 253 ]

1

[ "REACTOME" ]

[ "R-SCE-76066" ]

[ "REACTOME:R-SCE-76066" ]

1

[ "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6f40", "6f41", "6f42", "6f44", "7q5b" ]

10

[ "PUB00056255", "PUB00072595" ]

[ "11433012", "11419933" ]

[ "Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.", "The RNA polymerase III transcription apparatus." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Dikarya" ]

[ 253 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Transcription factor TFIIIB component B'', fungi

Bdp1_fungi

3

IPR017175

17,175

Inhibin, alpha subunit

Inhibin_asu

Family

754

false

Inhibins and activins are glycoproteins, secreted by the gonads, that belong to the transforming growth factor beta family [ ]. Inhibin inhibits secretion of follicle-stimulating hormone (FSH) by the pituitary [ ], and regulates ovarian folliculogenesis [ ] and steroidogenesis [ ]. Inhibin has two isoforms, A and B, wi...

[]

0

[ "PIRSF" ]

[ "PIRSF037328" ]

[ "Inhibin_alpha_subunit" ]

[ 754 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1502540", "R-BTA-201451", "R-BTA-209822", "R-BTA-9839406", "R-HSA-1502540", "R-HSA-201451", "R-HSA-209822", "R-HSA-9839406", "R-MMU-1502540", "R-MMU-201451", "R-MMU-209822", "R-MMU-9839406", "R-RNO-1502540", "R-RNO-201451", "R-RNO-209822", "R-RNO-9839406", "R-SSC-1502540", "...

[ "REACTOME:R-BTA-1502540", "REACTOME:R-BTA-201451", "REACTOME:R-BTA-209822", "REACTOME:R-BTA-9839406", "REACTOME:R-HSA-1502540", "REACTOME:R-HSA-201451", "REACTOME:R-HSA-209822", "REACTOME:R-HSA-9839406", "REACTOME:R-MMU-1502540", "REACTOME:R-MMU-201451", "REACTOME:R-MMU-209822", "REACTOME:R-MM...

20

[]

0

[ "PUB00003992", "PUB00004621", "PUB00082552", "PUB00082553" ]

[ "2417121", "3016724", "2123449", "3474640" ]

[ "Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta.", "Inhibin A-subunit cDNAs from porcine ovary and human placenta.", "Inhibin and activin locally regulate rat ovarian folliculogenesis.", "Heterodimers and homodimers of...

[ 1985, 1986, 1990, 1987 ]

4

[ "IPR015615" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 754 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 2 ]

4

true

Family

Inhibin, alpha subunit

Inhibin_asu

6

IPR017176

17,176

Alpha-(1, 3)-fucosyltransferase, metazoan

Alpha-1_3-FUT_met

Family

1,601

false

This group represents an alpha-(1,3)-fucosyltransferase, metazoan type. Helicobacter pylori is a prevalent bacterial, gastroduodenal pathogen of humans that can express Lewis (Le) and related antigens in the O-chains of its surface lipopolysaccharide. The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme ...

[ "GO:0046920", "GO:0009101", "GO:0000139" ]

[ "alpha-(1->3)-fucosyltransferase activity", "glycoprotein biosynthetic process", "Golgi membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037332" ]

[ "Alpha1_3FUT_met" ]

[ 1601 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.221", "R-HSA-5173105", "R-MMU-5173105", "R-RNO-5173105", "R-XTR-5173105" ]

[ "EC:2.4.1.221", "REACTOME:R-HSA-5173105", "REACTOME:R-MMU-5173105", "REACTOME:R-RNO-5173105", "REACTOME:R-XTR-5173105" ]

5

[]

0

[ "PUB00043799", "PUB00043800", "PUB00043801", "PUB00043802" ]

[ "18274891", "18279843", "18607721", "18491404" ]

[ "Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.", "Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori.", "Core saccharide dependence of sialyl Lewis X biosynthesis.", "Expression and enzyme activi...

[ 2008, 2008, 2008, 2008 ]

4

[ "IPR001503" ]

[]

1

0

1

[ "Bilateria" ]

[ 1601 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 5, 3, 7 ]

5

true

Family

Alpha-(1, 3)-fucosyltransferase, metazoan

Alpha-1_3-FUT_met

2

IPR017177

17,177

Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, plant

Alpha-1_3/4-FUT_pln

Family

496

false

Helicobacter pylori is a prevalent bacterial, gastroduodenal pathogen of humans that can express Lewis (Le) and related antigens in the O-chains of its surface lipopolysaccharide. The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme for synthesis of sialyl Lewis X and Lewis X in epithelial cells [ ]. Des...

[]

0

[ "PIRSF" ]

[ "PIRSF037334" ]

[ "Alpha1_3/4FUT_pln" ]

[ 496 ]

1

[]

0

[ "7yro" ]

1

[ "PUB00043799", "PUB00043800", "PUB00043801", "PUB00043802" ]

[ "18274891", "18279843", "18607721", "18491404" ]

[ "Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.", "Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori.", "Core saccharide dependence of sialyl Lewis X biosynthesis.", "Expression and enzyme activi...

[ 2008, 2008, 2008, 2008 ]

4

[ "IPR001503" ]

[]

1

0

1

[ "Eukaryota" ]

[ 496 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 4, 3 ]

3

true

Family

Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, plant

Alpha-1_3/4-FUT_pln

1

IPR017178

17,178

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical

IspG_atypical

Family

2,755

false

This entry includes 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, which converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4CPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate in the sixth step of nonmevalonate terpenoid biosynthesis. It is essential in Escherichia coli. The enzyme is described ...

[ "GO:0005506", "GO:0046429", "GO:0008299" ]

[ "iron ion binding", "4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin)", "isoprenoid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF037336" ]

[ "IspG_like" ]

[ 2755 ]

1

[ "EC" ]

[ "1.17.7.3" ]

[ "EC:1.17.7.3" ]

1

[]

0

[ "PUB00085129", "PUB00085130", "PUB00085131" ]

[ "15133149", "16167903", "15650872" ]

[ "CHLOROPLAST BIOGENESIS genes act cell and noncell autonomously in early chloroplast development.", "The Arabidopsis csb3 mutant reveals a regulatory link between salicylic acid-mediated disease resistance and the methyl-erythritol 4-phosphate pathway.", "Isoprenoid biosynthesis in chloroplasts via the methyler...

[ 2004, 2005, 2005 ]

3

[ "IPR004588" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "virus sp. ctVE78" ]

[ 1763, 956, 35, 1 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 7 ]

3

true

Family

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, atypical

IspG_atypical

4

IPR017179

17,179

Spastin

Family

1,205

false

Spastin is an ATP-dependent microtubule severing protein. Microtubule severing may promote reorganisation of cellular microtubule arrays and the release of microtubules from the microtubule organising centre following nucleation [ , , ].

[ "GO:0008568" ]

[ "microtubule severing ATPase activity" ]

[ "molecular_function" ]

1

[ "HAMAP" ]

[ "MF_03021" ]

[ "Spastin" ]

[ 1205 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.1.1", "R-BTA-9668328", "R-DDI-9668328", "R-DME-9668328", "R-DRE-9668328", "R-GGA-9668328", "R-HSA-9668328", "R-MMU-9668328", "R-RNO-9668328", "R-SSC-9668328", "R-XTR-9668328" ]

[ "EC:5.6.1.1", "REACTOME:R-BTA-9668328", "REACTOME:R-DDI-9668328", "REACTOME:R-DME-9668328", "REACTOME:R-DRE-9668328", "REACTOME:R-GGA-9668328", "REACTOME:R-HSA-9668328", "REACTOME:R-MMU-9668328", "REACTOME:R-RNO-9668328", "REACTOME:R-SSC-9668328", "REACTOME:R-XTR-9668328" ]

11

[ "6p07", "6pek", "6pen" ]

3

[ "PUB00053590", "PUB00063869", "PUB00063870", "PUB00063871" ]

[ "12676568", "11809724", "15716377", "10610178" ]

[ "The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia.", "Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.", "Linking axonal degeneration to microtubule remodeling by Spastin-mediated ...

[ 2003, 2002, 2005, 1999 ]

4

[]

[ "IPR035106" ]

0

1

0

[ "Eukaryota" ]

[ 1205 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 6, 3, 5 ]

5

true

Family

Spastin

2

IPR017180

17,180

Phosphotransferase system component IIBC, sugar-specific, predicted

PTS_IIBC_sugar_specific

Family

381

false

This group represents a predicted phosphotransferase system component IIBC, sugar-specific.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF007094", "PIRSF037343" ]

[ "PRK09548.1", "PTSIIBC_sugar_prd" ]

[ 381, 278 ]

2

[]

0

[ "5zov" ]

1

[]

0

[]

0

null

[ "Bacteria", "invertebrate metagenome" ]

[ 380, 1 ]

2

[]

0

true

Family

Phosphotransferase system component IIBC, sugar-specific, predicted

PTS_IIBC_sugar_specific

2

IPR017182

17,182

Methyltransferase METTL16/PsiM

METTL16/PsiM

Family

2,420

false

METTL16 is an U6 snRNA methyltransferase that methylates adenosine residues of a subset of RNAs. It plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts [ ]. This entry also includes PsiM from Psilocybe cubensis. PsiM is part of the gene cluster that mediates the biosynt...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037350" ]

[ "Mtase_ZK1128_prd" ]

[ 2420 ]

1

[ "EC" ]

[ "2.1.1.346" ]

[ "EC:2.1.1.346" ]

1

[ "2h00", "6b91", "6b92", "6du4", "6du5", "6gfk", "6gfn", "6gt5", "8gu3", "8pb3", "8pb4", "8pb5", "8pb6", "8pb7", "8pb8", "8qxq", "8zie", "8zig", "8zih", "8zii", "8zim", "8zio", "9fmh", "9fmi", "9fmj", "9fmk", "9gfs", "9gr6", "9gr7", "9u47", "9u48" ]

31

[ "PUB00086421", "PUB00086873" ]

[ "28525753", "28763571" ]

[ "The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention.", "Enzymatic Synthesis of Psilocybin." ]

[ 2017, 2017 ]

2

[ "IPR010286" ]

[]

1

0

1

[ "Eukaryota", "Pedobacter cryophilus" ]

[ 2419, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 9, 2, 2, 2, 2, 3, 3, 4, 1, 6 ]

10

true

Family

Methyltransferase METTL16/PsiM

METTL16/PsiM

6

IPR017183

17,183

Sigma54-dependent transcriptional activator, RtcR

Sigma54_dep_tscrpt_act_RtcR

Family

1,976

false

This entry represents sigma54-dependent transcriptional activators, such as RtcR from Escherichia coli. RtcR is a transcriptional repressor of rtcBA genes and directly interacts with sigma54 factor [ , ]. Bacterial transcription relies on the binding of dissociable sigma (sigma) factors to RNA polymerase (RNAP) for pro...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "PIRSF" ]

[ "NF038308", "PIRSF037354" ]

[ "RNA_repair_RtcR", "Txn_actvtr_RtcR" ]

[ 1968, 1930 ]

2

[]

0

[]

0

[ "PUB00012945", "PUB00042799", "PUB00042800" ]

[ "9738023", "14757243", "17157497" ]

[ "Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon.", "In silico analysis of the sigma54-dependent enhancer-binding proteins in Pirellula species strain 1.", "Bacterial enhancer-binding proteins: unlocking sigma54-dependent gene transcription." ]

[ 1998, 2004, 2007 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1970, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sigma54-dependent transcriptional activator, RtcR

Sigma54_dep_tscrpt_act_RtcR

9

IPR017184

17,184

Serine/threonine-protein kinase Unc-51

Ser/Thr_kinase_Unc51

Family

157

false

This entry represents serine/threonine-protein kinases ( ) such as Unc-51 from Caenorhabditis elegans. Unc-51 is important for axonal elongation and axonal guidance [ ]. It is required for either the maintenance of axons (membrane turnover) or for an unknown neuronal function. C elegans worms lacking Unc-51 exhibit var...

[ "GO:0004672", "GO:0010506" ]

[ "protein kinase activity", "regulation of autophagy" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037369" ]

[ "Ser/Thr_PK_unc51" ]

[ 157 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-1632852", "R-CEL-8854214", "R-CEL-8934903" ]

[ "REACTOME:R-CEL-1632852", "REACTOME:R-CEL-8854214", "REACTOME:R-CEL-8934903" ]

3

[]

0

[ "PUB00042769", "PUB00042770" ]

[ "16887826", "17890369" ]

[ "The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans.", "Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans." ]

[ 2006, 2007 ]

2

[ "IPR045269" ]

[]

1

0

1

[ "Protostomia" ]

[ 157 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 1, 2 ]

2

true

Family

Serine/threonine-protein kinase Unc-51

Ser/Thr_kinase_Unc51

2

IPR017185

17,185

Uncharacterised conserved protein UCP037373

UCP037373

Family

352

false

This group represents a predicted transcriptional regulator, AF0674 type such as .

[]

0

[ "PIRSF" ]

[ "PIRSF037373" ]

[ "UCP037373_trxn_reg" ]

[ 352 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Candidatus Woesebacteria bacterium RBG_16_34_12", "Methanobacteriati", "ecological metagenomes" ]

[ 1, 339, 12 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP037373

UCP037373

3

IPR017186

17,186

Lipase, autotransporter EstA

Lipase_autotranspt_EstA

Family

2,264

false

This group represents an autotransporting lipolytic enzyme, EstA type.

[]

0

[ "PIRSF" ]

[ "PIRSF037375" ]

[ "Autotrns_EstA" ]

[ 2264 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.1.1", "PWY-6303", "PWY-6857", "PWY-8454" ]

[ "EC:3.1.1.1", "METACYC:PWY-6303", "METACYC:PWY-6857", "METACYC:PWY-8454" ]

4

[ "3kvn" ]

1

[]

0

[]

[ "IPR048099" ]

0

1

0

[ "Opisthokonta", "Pseudomonadati", "mine drainage metagenome", "uncultured Caudovirales phage" ]

[ 2, 2258, 3, 1 ]

4

[]

0

true

Family

Lipase, autotransporter EstA

Lipase_autotranspt_EstA

5

IPR017187

17,187

Ethylene-insensitive protein 2

EIN2

Family

959

false

This entry represents ethylene-insensitive protein 2. This protein plays a central role in signalling pathways regulated by ethylene (ET), and involved in various processes including development, plant defence, senescence, nucleotide sugar flux, and tropisms [ , , , ].

[ "GO:0009873" ]

[ "ethylene-activated signaling pathway" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF037378" ]

[ "EIN2" ]

[ 959 ]

1

[]

0

[]

0

[ "PUB00042859", "PUB00042860", "PUB00042861", "PUB00042862" ]

[ "7770519", "12953109", "9351240", "14973160" ]

[ "Cytokinin action is coupled to ethylene in its effects on the inhibition of root and hypocotyl elongation in Arabidopsis thaliana seedlings.", "Analysis of combinatorial loss-of-function mutants in the Arabidopsis ethylene receptors reveals that the ers1 etr1 double mutant has severe developmental defects that a...

[ 1995, 2003, 1997, 2004 ]

4

[ "IPR001046" ]

[]

1

0

1

[ "Embryophyta" ]

[ 959 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 23 ]

3

true

Family

Ethylene-insensitive protein 2

EIN2

4

IPR017189

17,189

CTP:phosphocholine cytidylyltransferase

CTP-phospocholine_CTT

Family

404

false

This family includes CTP:phosphocholine cytidylyltransferase from Streptococcus pneumoniae, also known as Choline-phosphate cytidylyltransferase, which is involved in the biosynthesis of the phosphocholine containing cell wall constituents, teichoic acid and lipoteichoic acid, which are essential for cell separation an...

[]

0

[ "PIRSF" ]

[ "PIRSF037382" ]

[ "CCT_LicC" ]

[ 404 ]

1

[]

0

[ "1jyk", "1jyl" ]

2

[ "PUB00153402", "PUB00153403" ]

[ "31420548", "8837483" ]

[ "The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis.", "Investigation of a choline phosphate synthesis pathway in Streptococcus pneumoniae: evidence for choline phosphate cytidylyltransferase activity." ]

[ 2019, 1996 ]

2

[ "IPR050065" ]

[]

1

0

1

[ "Bacteria", "human gut metagenome" ]

[ 403, 1 ]

2

[]

0

true

Family

CTP:phosphocholine cytidylyltransferase

CTP-phospocholine_CTT

2

IPR017190

17,190

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase

Bifunc_CCT/choline_kinase

Family

106

false

This group represents uncharacterised proteins that may be involved in LPS biosynthesis. All proteins in this group possess a choline/ethanolamine kinase domain and many also have a MobA-like NTP transferase domain.

[]

0

[ "PIRSF" ]

[ "PIRSF037383" ]

[ "LicCA" ]

[ 106 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 105, 1 ]

2

[]

0

true

Family

Bifunctional CTP:phosphocholine cytidylyltransferase/choline kinase

Bifunc_CCT/choline_kinase

5

IPR017191

17,191

Junctophilin

Family

4,835

false

This entry includes junctophilin 1-4 from animals.

[ "GO:0030314" ]

[ "junctional membrane complex" ]

[ "cellular_component" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF037387", "PTHR23085" ]

[ "Junctophilin", "" ]

[ 1559, 4835 ]

2

[]

0

[ "7rw4", "7rxe", "7rxq" ]

3

[ "PUB00078069", "PUB00078071" ]

[ "12729900", "24636942" ]

[ "Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1.", "The junctophilin family of proteins: from bench to bedside." ]

[ 2003, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4835 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 3, 16, 7, 10 ]

6

true

Family

Junctophilin

4

IPR017192

17,192

Thiosulphate:quinone oxidoreductase, fused subunit DoxA/ DoxD

ThioSO4-Q_OxRdtase_DoxA/D

Family

634

false

This group represents a putative thiosulphate:quinone oxidoreductase, fused subunits DoxA and DoxD.

[]

0

[ "PIRSF" ]

[ "PIRSF037390" ]

[ "Thiosulph_Quin_oxidored_DoxA-D" ]

[ 634 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 629, 5 ]

2

[]

0

true

Family

Thiosulphate:quinone oxidoreductase, fused subunit DoxA/ DoxD

ThioSO4-Q_OxRdtase_DoxA/D

9

IPR017194

17,194

Transforming growth factor-beta receptor, type II

Transform_growth_fac-b_typ-2

Family

2,136

false

This entry represents the transforming growth factor (TGF)-beta receptor type-2, which has serine/threonion kinase activity ( ) and uses magnesium or manganese as a cofactor. These proteins are the receptors for TGF-beta, a large family of growth and differentiation factors that mobilise complex signalling networks to ...

[ "GO:0004674", "GO:0038023", "GO:0046872", "GO:0007178", "GO:0016020", "GO:0043235" ]

[ "protein serine/threonine kinase activity", "signaling receptor activity", "metal ion binding", "cell surface receptor protein serine/threonine kinase signaling pathway", "membrane", "receptor complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF037393" ]

[ "TGFRII" ]

[ 2136 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.30", "R-GGA-2173788", "R-GGA-2173789", "R-GGA-2173791", "R-GGA-9839389", "R-HSA-2173788", "R-HSA-2173789", "R-HSA-2173791", "R-HSA-3304356", "R-HSA-3642279", "R-HSA-3645790", "R-HSA-3656532", "R-HSA-3656535", "R-HSA-5689603", "R-HSA-9839389", "R-MMU-2173788", "R-MMU-2173789",...

[ "EC:2.7.11.30", "REACTOME:R-GGA-2173788", "REACTOME:R-GGA-2173789", "REACTOME:R-GGA-2173791", "REACTOME:R-GGA-9839389", "REACTOME:R-HSA-2173788", "REACTOME:R-HSA-2173789", "REACTOME:R-HSA-2173791", "REACTOME:R-HSA-3304356", "REACTOME:R-HSA-3642279", "REACTOME:R-HSA-3645790", "REACTOME:R-HSA-36...

23

[]

0

[ "PUB00044617", "PUB00044618", "PUB00044619", "PUB00044620", "PUB00044621" ]

[ "18310276", "9500552", "11078757", "15731757", "16791849" ]

[ "Transforming growth factor-beta signaling and ubiquitinators in cancer.", "Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.", "Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.", "A syndrome of altered cardi...

[ 2008, 1998, 2000, 2005, 2006 ]

5

[ "IPR000333" ]

[]

1

0

1

[ "Metazoa" ]

[ 2136 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 30, 1, 5, 7, 6 ]

5

true

Family

Transforming growth factor-beta receptor, type II

Transform_growth_fac-b_typ-2

4

IPR017195

17,195

ABC-type thiamin-related transport system, permease component 1, predicted

ABC_thiamin-permease_prd

Family

4,827

false

This group represents a predicted ABC-type thiamin-related transport system, permease component 1. It is probably part of the ABC transporter complex ykoCDEF that could transport hydroxymethylpyrimidine (HMP) and/or thiamine. It could also transport other HMP-containing products. The complex is composed of two ATP-bind...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09819", "PIRSF037394" ]

[ "ABC_cobalt", "ABC_thiamine-permease_YkoE_prd" ]

[ 4827, 3805 ]

2

[ "GP" ]

[ "GenProp1094" ]

[ "GP:GenProp1094" ]

1

[ "5edl" ]

1

[ "PUB00070815" ]

[ "16291685" ]

[ "Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 60, 4748, 19 ]

3

[]

0

true

Family

ABC-type thiamin-related transport system, permease component 1, predicted

ABC_thiamin-permease_prd

7

IPR017196

17,196

ECF transporter, predicted substrate-specific component UCP037395

ECF_substrate-spec_UCP037395

Family

2,134

false

Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module [ ]. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-couplin...

[]

0

[ "PIRSF" ]

[ "PIRSF037395" ]

[ "UCP037395_ABCper" ]

[ 2134 ]

1

[]

0

[]

0

[ "PUB00056162" ]

[ "18931129" ]

[ "A novel class of modular transporters for vitamins in prokaryotes." ]

[ 2009 ]

1

[ "IPR024529" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriati", "metagenomes" ]

[ 2013, 4, 117 ]

3

[]

0

true

Family

ECF transporter, predicted substrate-specific component UCP037395

ECF_substrate-spec_UCP037395

3

IPR017197

17,197

Bone morphogenetic protein 3/3B

BMP3/BMP3B

Family

861

false

This group includes two members of the TGF-beta superfamily: bone morphogenetic protein 3 (BMP3) and bone morphogenetic protein 3B (BMP3B), also known as growth differentiation factor 10 (GDF10). Together they represent a subgroup of the BMP family. They are involved in development and organogenesis. In developing embr...

[ "GO:0001649" ]

[ "osteoblast differentiation" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF037403" ]

[ "BMP3/GDF10" ]

[ 861 ]

1

[]

0

[]

0

[ "PUB00073607", "PUB00073608", "PUB00073609" ]

[ "11138004", "22155034", "14977563" ]

[ "Bone morphogenetic protein-3 is a negative regulator of bone density.", "Bone morphogenetic protein-3b (BMP-3b) inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling.", "Bone morphogenetic protein-3 family members and their biological functions." ]

[ 2001, 2012, 2004 ]

3

[ "IPR015615" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 861 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 5, 6 ]

4

true

Family

Bone morphogenetic protein 3/3B

BMP3/BMP3B

2

IPR017199

17,199

Uncharacterised conserved protein UCP037409, membrane transporter, MTH672

UCP037409_transporter

Family

257

false

This group represents a predicted membrane transporter, MTH672 type.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09930", "PIRSF037409" ]

[ "DUF2162", "UCP037409_transporter" ]

[ 257, 192 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 55, 194, 8 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP037409, membrane transporter, MTH672

UCP037409_transporter

5

IPR017200

17,200

Coenzyme PQQ synthesis protein E-like

PqqE-like

Family

11,312

false

This entry represents coenzyme PQQ biosynthesis protein E, which is a prototypical peptide-cyclising radical SAM enzyme. It links a Tyr to a Glu as the first step in the biosynthesis of pyrrolo-quinoline-quinone (coenzyme PQQ) from the precursor peptide PqqA. PQQ is required for some glucose dehydrogenases and alcohol ...

[]

0

[ "PIRSF" ]

[ "PIRSF037420" ]

[ "PQQ_syn_pqqE" ]

[ 11312 ]

1

[ "EC", "METACYC" ]

[ "1.21.98.4", "PWY-6420" ]

[ "EC:1.21.98.4", "METACYC:PWY-6420" ]

2

[ "6c8v" ]

1

[ "PUB00083604" ]

[ "24669201" ]

[ "The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri." ]

[ 2014 ]

1

[]

[ "IPR011843", "IPR023913", "IPR023992", "IPR026344", "IPR026346", "IPR026404", "IPR026482", "IPR027570", "IPR027583", "IPR027626", "IPR027633", "IPR034479", "IPR034480" ]

0

13

0

[ "Archaea", "Bacteria", "Eukaryota", "Methanophagales virus PBV082", "unclassified sequences" ]

[ 1180, 9937, 5, 1, 189 ]

5

[]

0

true

Family

Coenzyme PQQ synthesis protein E-like

PqqE-like

4

IPR017201

17,201

Uncharacterised conserved protein UCP037429

UCP037429

Family

106

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF037429" ]

[ "UCP037429" ]

[ 106 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Nitrobacteraceae" ]

[ 106 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP037429

UCP037429

6

IPR017203

17,203

Signal transduction histidine kinase, NreB

Sig_transdc_His_kinase_NreB

Family

580

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[ "GO:0000155", "GO:0004673", "GO:0005506", "GO:0005524", "GO:0018106", "GO:0005737" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "iron ion binding", "ATP binding", "peptidyl-histidine phosphorylation", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF037432" ]

[ "STHK_NreB" ]

[ 580 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[]

0

[ "PUB00010651", "PUB00011096", "PUB00042804", "PUB00042805", "PUB00042810" ]

[ "12372152", "10966457", "16176121", "18076326", "15101978" ]

[ "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.", "Specificity in two-component signal transduction pathways....

[ 2002, 2000, 2005, 2007, 2004 ]

5

[ "IPR050482" ]

[]

1

0

1

[ "Bacteria", "bioreactor metagenome" ]

[ 579, 1 ]

2

[]

0

true

Family

Signal transduction histidine kinase, NreB

Sig_transdc_His_kinase_NreB

7

IPR017204

17,204

Signal transduction histidine kinase, STH3221, predicted

Sig_transdc_His_kin_STH3221

Family

57

false

This entry represents proteins predicted to act as signal transduction histidine kinases, such as STH3221 from Symbiobacterium thermophilum. Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in mi...

[]

0

[ "PIRSF" ]

[ "PIRSF037433" ]

[ "STHK_STH3221_prd" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[ "IPR050482" ]

[]

1

0

1

[ "Bacteria", "bioreactor metagenome" ]

[ 55, 2 ]

2

[]

0

true

Family

Signal transduction histidine kinase, STH3221, predicted

Sig_transdc_His_kin_STH3221

2

IPR017205

17,205

Signal transduction histidine kinase, ChrS

Sig_transdc_His_kinase_ChrS

Family

5,842

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[]

0

[ "PIRSF" ]

[ "PIRSF037434" ]

[ "STHK_ChrS" ]

[ 5842 ]

1

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[ "IPR050482" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 5836, 6 ]

2

[]

0

true

Family

Signal transduction histidine kinase, ChrS

Sig_transdc_His_kinase_ChrS

1

IPR017206

17,206

Signal transduction histidine kinase, hybrid-type, BC3207, predicted

Sig_transdc_His_kin_hyb_BC3207

Family

135

false

This entry represents predicted hybrid signal transduction histidine kinases, BC3207 type. Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems th...

[]

0

[ "PIRSF" ]

[ "PIRSF037435" ]

[ "Hybr_HK_BC3207_prd" ]

[ 135 ]

1

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[]

0

null

[ "Bacillaceae" ]

[ 135 ]

1

[]

0

true

Family

Signal transduction histidine kinase, hybrid-type, BC3207, predicted

Sig_transdc_His_kin_hyb_BC3207

4

IPR017207

17,207

Mitochondrial translation factor Atp22, Saccharomycetaceae

Atp22_saccharomyc

Family

20

false

This entry represents the mitochondrial translation factor Atp22, which is specific for subunit 6 of the mitochondrial ATPase [ , ]. Atp22 is a component of the mitochondrial inner membrane required for the expression of the CF(0) component of the ATPase [ ]. Members of this entry are found in Saccharomycetales.

[ "GO:0045182", "GO:0006417", "GO:0005743" ]

[ "translation regulator activity", "regulation of translation", "mitochondrial inner membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037437" ]

[ "Atp22" ]

[ 20 ]

1

[]

0

[]

0

[ "PUB00044703", "PUB00044704" ]

[ "12646576", "17110482" ]

[ "ATP22, a nuclear gene required for expression of the F0 sector of mitochondrial ATPase in Saccharomyces cerevisiae.", "The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6-specific translation factor." ]

[ 2003, 2007 ]

2

[ "IPR060761" ]

[]

1

0

1

[ "Saccharomycetaceae" ]

[ 20 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial translation factor Atp22, Saccharomycetaceae

Atp22_saccharomyc

6

IPR017209

17,209

Alpha/beta hydrolase, predicted

Abhydr

Family

80

false

This group represents a predicted alpha/beta hydrolase.

[]

0

[ "PIRSF" ]

[ "PIRSF037445" ]

[ "UCP037445_abhydr" ]

[ 80 ]

1

[]

0

[]

0

[]

0

[ "IPR000639" ]

[]

1

0

1

[ "Leptospira" ]

[ 80 ]

1

[]

0

true

Family

Alpha/beta hydrolase, predicted

Abhydr

2

IPR017210

17,210

Actin patch protein 1

APP1

Family

833

false

This entry includes phosphatidate phosphatase App1 from budding yeasts. It is a Mg2+-dependent phosphatidate (PA) phosphatase which catalyses the dephosphorylation of PA to yield diacylglycerol. It may play a role in vesicular trafficking through its PAP activity at cortical actin patches [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF037464" ]

[ "UCP037464_APP1" ]

[ 833 ]

1

[]

0

[]

0

[ "PUB00071676" ]

[ "23071111" ]

[ "The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme." ]

[ 2012 ]

1

[]

0

null

[ "Dikarya" ]

[ 833 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Actin patch protein 1

APP1

7

IPR017211

17,211

Uncharacterised conserved protein UCP037465, zinc finger protein, AF1427

UCP037465_Znf

Family

442

false

This group represents a predicted zinc finger protein, AF1427 type.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09947", "PIRSF037465" ]

[ "DUF2180", "UCP037465_Znf" ]

[ 442, 146 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Hucho hucho", "Methanobacteriota", "ecological metagenomes" ]

[ 238, 1, 198, 5 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP037465, zinc finger protein, AF1427

UCP037465_Znf

1

IPR017212

17,212

Clathrin heavy chain linker domain-containing protein 1

CLHC1

Family

474

false

This group represents a clathrin heavy chain-related protein.

[]

0

[ "PIRSF" ]

[ "PIRSF037469" ]

[ "Clathrin_H-chain-rel" ]

[ 474 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 474 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3 ]

3

true

Family

Clathrin heavy chain linker domain-containing protein 1

CLHC1

8

IPR017213

17,213

Peptidase S54, rhomboid, metazoan

Peptidase_S54_rhomboid_met

Family

2,795

false

This entry represents metazoan rhomboid proteins ( ), integral membrane proteins thought to be involved in regulated intra-membrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors [ ]. Rhomboid proteins cleave type-1 transmembrane domains using a catalytic triad composed of...

[ "GO:0004252", "GO:0016020" ]

[ "serine-type endopeptidase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF037470" ]

[ "Rhomboid" ]

[ 2795 ]

1

[ "EC" ]

[ "3.4.21.105" ]

[ "EC:3.4.21.105" ]

1

[]

0

[ "PUB00042686" ]

[ "17114579" ]

[ "Rhomboid proteins: conserved membrane proteases with divergent biological functions." ]

[ 2006 ]

1

[]

0

null

[ "Bilateria", "bird metagenome" ]

[ 2794, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 27, 9, 3, 5, 6 ]

6

true

Family

Peptidase S54, rhomboid, metazoan

Peptidase_S54_rhomboid_met

6

IPR017214

17,214

Cytochrome b561 and DOMON domain-containing protein

UCP037471

Family

3,885

false

This entry represents a group of DOMON domain (named after DOpamine beta-MOnooxygenase N-terminal domain) containing proteins from plants. They also contain a cytochrome b561 domain C-terminal to the DOMON domain. DOMON domain could bind catecholamines and thereby could regulate the cytochrome b561 domain function. Pro...

[]

0

[ "PIRSF" ]

[ "PIRSF037471" ]

[ "UCP037471" ]

[ 3885 ]

1

[]

0

[]

0

[ "PUB00072923" ]

[ "15022831" ]

[ "Analysis of an Arabidopsis thaliana protein family, structurally related to cytochromes b561 and potentially involved in catecholamine biochemistry in plants." ]

[ 2004 ]

1

[]

0

null

[ "Streptophytina" ]

[ 3885 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 34, 16, 36 ]

3

true

Family

Cytochrome b561 and DOMON domain-containing protein

UCP037471

1

IPR017215

17,215

5-methyltetrahydrofolate-homocysteine S-methyltransferase, bacterial

MetH_bac

Family

1,386

false

This group represents a bacterial form of the 5-methyltetrahydrofolate-homocysteine S-methyltransferase MetH.

[]

0

[ "PIRSF" ]

[ "PIRSF037472" ]

[ "DHPS_mtfrase" ]

[ 1386 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Promethearchaeum syntrophicum", "ecological metagenomes" ]

[ 1374, 1, 11 ]

3

[]

0

true

Family

5-methyltetrahydrofolate-homocysteine S-methyltransferase, bacterial

MetH_bac

8

IPR017216

17,216

Hermansky-Pudlak syndrome 3 protein

HPS3

Family

1,862

false

The Hermansky-Pudlak syndrome 3 protein, also known as BLOC-2 complex member HPS3, is involved in early stages of melanosome biogenesis and maturation [ ]. Hermansky-Pudlak syndrome 3 (HPS3) is a form of Hermansky-Pudlak syndrome, a genetically heterogeneous autosomal recessive disorder characterised by oculocutaneous ...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF037473", "PTHR28633" ]

[ "BLOC-2_complex_Hps3", "" ]

[ 383, 1862 ]

2

[]

0

[]

0

[ "PUB00067608", "PUB00067609" ]

[ "11455388", "11590544" ]

[ "Mutation of a new gene causes a unique form of Hermansky-Pudlak syndrome in a genetic isolate of central Puerto Rico.", "Hermansky-Pudlak syndrome type 3 in Ashkenazi Jews and other non-Puerto Rican patients with hypopigmentation and platelet storage-pool deficiency." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1862 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 8, 3 ]

5

true

Family

Hermansky-Pudlak syndrome 3 protein

HPS3

7

IPR017218

17,218

BLOC-2 complex, Hps6 subunit

BLOC-2_complex_Hps6_subunit

Family

884

false

Lysosome-related organelles comprise a group of specialised intracellular compartments that include melanosomes and platelet dense granules in mammals and eye pigment granules in insects. Hermansky-Pudlak syndrome (HPS) is a disorder of lysosome-related organelle biogenesis. Genes associated with HPS encode subunits of...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF037476", "PTHR14696" ]

[ "BLOC-2_complex_Hps6", "" ]

[ 128, 884 ]

2

[]

0

[]

0

[ "PUB00043620", "PUB00043621", "PUB00043622", "PUB00043623", "PUB00043624", "PUB00101253", "PUB00101254" ]

[ "17156100", "17365864", "17182842", "16837549", "15030569", "17041891", "25189619" ]

[ "The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5).", "Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome.", "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles.", ...

[ 2007, 2007, 2007, 2006, 2004, 2006, 2014 ]

7

[]

0

null

[ "Eukaryota" ]

[ 884 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3 ]

4

true

Family

BLOC-2 complex, Hps6 subunit

BLOC-2_complex_Hps6_subunit

4

IPR017219

17,219

Peptidoglycan GlcNAc deacetylase

Peptidoglycan_deacetylase

Family

315

false

This entry represents peptidoglycan GlcNAc deacetylases, including Peptidoglycan-N-acetylglucosamine deacetylase (PgdA) from Streptococcus pneumoniae, which confers host lysozyme resistance and contributes to pneumococcal virulence [ , ]. Structural analysis from S. pneumoniae revealed that PGDA is a metalloenzyme usin...

[]

0

[ "PIRSF" ]

[ "PIRSF037479" ]

[ "PG_GlcNAc_deacetylase" ]

[ 315 ]

1

[ "EC" ]

[ "3.5.1.104" ]

[ "EC:3.5.1.104" ]

1

[ "2c1g", "2c1i" ]

2

[ "PUB00039846", "PUB00084363", "PUB00096675" ]

[ "16221761", "22277649", "25157076" ]

[ "Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.", "Identification and characterization of a novel polysaccharide deacetylase C (PdaC) from Bacillus subtilis.", "Listeria monocytogenes is resistant to lysozyme through the regulation, not the acquisition, o...

[ 2005, 2012, 2014 ]

3

[]

0

null

[ "Bacteria" ]

[ 315 ]

1

[]

0

true

Family

Peptidoglycan GlcNAc deacetylase

Peptidoglycan_deacetylase

9

IPR017220

17,220

Sulphite reductase, assimilatory

Sulphite_reductase_assimil

Family

641

false

This group represents a sulphite reductase, assimilatory type.

[]

0

[ "PIRSF" ]

[ "PIRSF037487" ]

[ "Sulfite_red_assimil" ]

[ 641 ]

1

[]

0

[]

0

[]

0

[ "IPR052034" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 443, 185, 13 ]

3

[]

0

true

Family

Sulphite reductase, assimilatory

Sulphite_reductase_assimil

7

IPR017221

17,221

DUF34/NIF3, bacteria

DUF34/NIF3_bac

Family

6,532

false

This family represents DUF34/metal-binding proteins (previously known as GTP cyclohydrolase 1 type 2) from bacteria. This entry includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 [ ] and, recently, thro...

[]

0

[ "PIRSF" ]

[ "PIRSF037489" ]

[ "UCP037489_NIF3_YqfO" ]

[ 6532 ]

1

[]

0

[ "2gx8", "2nyd", "3lnl" ]

3

[ "PUB00002954", "PUB00019927", "PUB00070175", "PUB00100327" ]

[ "8663102", "11124544", "23825549", "34572495" ]

[ "Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p.", "Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals.", "Biochemical Characterization of Hypothetical Proteins from Helicobacter pylo...

[ 1996, 2000, 2013, 2021 ]

4

[ "IPR002678" ]

[]

1

0

1

[ "Bacteria", "Myoviridae sp. ct2th6", "Opisthokonta", "metagenomes" ]

[ 6417, 1, 73, 41 ]

4

[]

0

true

Family

DUF34/NIF3, bacteria

DUF34/NIF3_bac

4

IPR017222

17,222

DUF34/NIF3, animal

DUF34/NIF3_animal

Family

1,049

false

This entry represents DUF34/metal-binding proteins (also referred to as NIF3-like protein 1) from animals. They share protein sequence similarity with budding yeast NIF3, which interacts with the yeast transcriptional coactivator Ngg1p that is part of the ADA complex [ , ]. This entry includes the DUF34/metal-binding p...

[]

0

[ "PIRSF" ]

[ "PIRSF037490" ]

[ "UCP037490_NIF3_euk" ]

[ 1049 ]

1

[]

0

[]

0

[ "PUB00002954", "PUB00019927", "PUB00070175", "PUB00100327" ]

[ "8663102", "11124544", "23825549", "34572495" ]

[ "Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p.", "Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals.", "Biochemical Characterization of Hypothetical Proteins from Helicobacter pylo...

[ 1996, 2000, 2013, 2021 ]

4

[ "IPR002678" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1049 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 5, 7 ]

4

true

Family

DUF34/NIF3, animal

DUF34/NIF3_animal

7

IPR017223

17,223

Predicted hydrolase of the HAD superfamily, SPs0319-type

HAD_SPs0319-typ

Family

264

false

This group represents a predicted hydrolase of the HAD superfamily, SPs0319-type ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF037492" ]

[ "UCP037492_HAD" ]

[ 264 ]

1

[]

0

[]

0

[]

0

[ "IPR000150" ]

[]

1

0

1

[ "Streptococcaceae" ]

[ 264 ]

1

[]

0

true

Family

Predicted hydrolase of the HAD superfamily, SPs0319-type

HAD_SPs0319-typ

1

IPR017224

17,224

Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B

Opine_Oxase_asu/HCN_bsu

Family

5,916

false

This entry represents subunit A of opine oxidase, which is involved in the oxidative cleavage of octopine into L-arginine and pyruvate during octopine degradation as part of opine metabolism in bacteria. Opine oxidase exists as a heterodimer of one subunit A and one subunit B.

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF037495" ]

[ "Opine_OX_OoxA/HcnB" ]

[ 5916 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5862, 4, 50 ]

3

[]

0

true

Family

Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B

Opine_Oxase_asu/HCN_bsu

2

IPR017225

17,225

Cell shape-determining protein MreD, predicted

Cell_shape_determin_MreD_prd

Family

813

false

The MreD (murein formation D) protein is involved in bacterial cell shape determination. Most rod-shaped bacteria depend on MreB and RodA to achieve either a rod shape or some other non-spherical morphology such as coil or stalk formation. MreD is encoded in an operon with MreB, and often with RodA and PBP-2 as well. I...

[]

0

[ "PIRSF" ]

[ "PIRSF037497" ]

[ "MreD_Clostridium/Treponema_prd" ]

[ 813 ]

1

[]

0

[]

0

[]

0

[ "IPR007227" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 794, 19 ]

2

[]

0

true

Family

Cell shape-determining protein MreD, predicted

Cell_shape_determin_MreD_prd

1

IPR017226

17,226

Betaine-homocysteine S-methyltransferase-like

BHMT-like

Family

10,873

false

Betaine-homocysteine methyltransferase (BHMT) is involved in the regulation of homocysteine metabolism. It converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. BHMT requires a thiol reducing agent for its activity. T...

[ "GO:0008168", "GO:0008270" ]

[ "methyltransferase activity", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF037505" ]

[ "Betaine_HMT" ]

[ 10873 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "R-DRE-1614635", "R-DRE-6798163", "R-HSA-1614635", "R-HSA-6798163", "R-MMU-1614635", "R-MMU-6798163", "R-RNO-1614635", "R-RNO-6798163", "R-XTR-1614635", "R-XTR-6798163" ]

[ "EC:2.1.1", "REACTOME:R-DRE-1614635", "REACTOME:R-DRE-6798163", "REACTOME:R-HSA-1614635", "REACTOME:R-HSA-6798163", "REACTOME:R-MMU-1614635", "REACTOME:R-MMU-6798163", "REACTOME:R-RNO-1614635", "REACTOME:R-RNO-6798163", "REACTOME:R-XTR-1614635", "REACTOME:R-XTR-6798163" ]

11

[ "1lt7", "1lt8", "1umy", "4m3p", "5dml", "5dmm", "5dmn", "8d45" ]

8

[ "PUB00043610", "PUB00043611", "PUB00043612", "PUB00043613", "PUB00085090", "PUB00085091" ]

[ "18262489", "17705221", "18498552", "18230605", "11013242", "15863700" ]

[ "Liver betaine-homocysteine S-methyltransferase activity undergoes a redox switch at the active site zinc.", "Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes.", "Effect of transgenic extrahepatic expression of betaine-homocystein...

[ 2008, 2007, 2008, 2008, 2000, 2005 ]

6

[]

[ "IPR051524" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 29, 6132, 4497, 215 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", ...

[ 14, 1, 11, 1, 7, 2, 8, 7, 1, 1, 12 ]

11

true

Family

Betaine-homocysteine S-methyltransferase-like

BHMT-like

1

IPR017227

17,227

Nucleoside-triphosphatase, alveolata

NTPase_alveloata

Family

14

false

This entry represents nucleoside-triphosphatase ( ) from parasites such as Toxoplasma gondii [ ]. This enzyme acts as a heterotetramer. It is secreted and has been detected in host cell parasitophorous vacuoles, where it may perform an important processing step in the conversion of high energy nucleotides prior to upta...

[ "GO:0017111", "GO:0005576" ]

[ "ribonucleoside triphosphate phosphatase activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF037506" ]

[ "NTPase" ]

[ 14 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.15", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:3.6.1.15", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

6

[ "3agr", "4a57", "4a59", "4a5a", "4a5b", "4jep", "4kh4", "4kh5", "4kh6" ]

9

[ "PUB00044622" ]

[ "12850206" ]

[ "The relationship between nucleoside triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis." ]

[ 2003 ]

1

[ "IPR000407" ]

[]

1

0

1

[ "Sarcocystidae" ]

[ 14 ]

1

[]

0

true

Family

Nucleoside-triphosphatase, alveolata

NTPase_alveloata

9

IPR017229

17,229

Multidomain scavenger receptor-like protein PxSR

Scavenger_rcpt_PxSR

Family

124

false

This group represents a multidomain scavenger receptor-like protein only found in Apicomplexa parasites. PxSR from the malaria parasite has not only a role in sporogonic development, it may also have a multiplicity of functions [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF037512" ]

[ "PxSR" ]

[ 124 ]

1

[]

0

[]

0

[ "PUB00072701" ]

[ "12354219" ]

[ "A malaria scavenger receptor-like protein essential for parasite development." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 124 ]

1

[]

0

true

Family

Multidomain scavenger receptor-like protein PxSR

Scavenger_rcpt_PxSR

3

IPR017230

17,230

Rab geranylgeranyltransferase complex component A

Mrs6

Family

1,192

false

This group represents the substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex from fungi [ , ].

[ "GO:0007264" ]

[ "small GTPase-mediated signal transduction" ]

[ "biological_process" ]

1

[ "PIRSF", "PRINTS" ]

[ "PIRSF037514", "PR00894" ]

[ "Rab_ger_ger_transf_A_fun", "YEASTMRS6P" ]

[ 1153, 275 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-6803205", "R-SCE-8873719", "R-SCE-8876198", "R-SPO-6803205", "R-SPO-8873719", "R-SPO-8876198" ]

[ "REACTOME:R-SCE-6803205", "REACTOME:R-SCE-8873719", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-6803205", "REACTOME:R-SPO-8873719", "REACTOME:R-SPO-8876198" ]

6

[]

0

[ "PUB00074966", "PUB00078876" ]

[ "8132658", "7750142" ]

[ "The Saccharomyces cerevisiae MSI4 gene encodes the yeast counterpart of component A of Rab geranylgeranyltransferase.", "Mrs6p, the yeast homologue of the mammalian choroideraemia protein: immunological evidence for its function as the Ypt1p Rab escort protein." ]

[ 1994, 1994 ]

2

[ "IPR018203" ]

[]

1

0

1

[ "Eukaryota", "Nonomuraea solani" ]

[ 1191, 1 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1, 1, 1 ]

4

true

Family

Rab geranylgeranyltransferase complex component A

Mrs6

7

IPR017231

17,231

Small GTPase Tem1/Spg1

Small_GTPase_Tem1/Spg1

Family

2,389

false

Small GTPases form an independent superfamily within the larger class of regulatory GTP hydrolases. This superfamily contains proteins that control a vast number of important processes and possess a common, structurally preserved GTP-binding domain [ , ]. Sequence comparisons of small G proteins from various species ha...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF037527", "cd04128" ]

[ "Small_GTPase_Tem1", "Spg1" ]

[ 1786, 2055 ]

2

[]

0

[]

0

[ "PUB00000348", "PUB00004087", "PUB00015117", "PUB00023196", "PUB00052600", "PUB00085367", "PUB00085368", "PUB00085699" ]

[ "2029511", "1898771", "11995995", "2196171", "2122258", "18252797", "16431930", "9203579" ]

[ "The ras protein family: evolutionary tree and role of conserved amino acids.", "The GTPase superfamily: conserved structure and molecular mechanism.", "Structure of small G proteins and their regulators.", "Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implicat...

[ 1991, 1991, 2001, 1990, 1990, 2008, 2006, 1997 ]

8

[ "IPR001806" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2389 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 1, 2, 1, 1, 5 ]

6

true

Family

Small GTPase Tem1/Spg1

Small_GTPase_Tem1/Spg1

3

IPR017232

17,232

Nitrogen regulation protein NtrY

NtrY

Family

5,280

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[]

0

[ "PIRSF" ]

[ "PIRSF037532" ]

[ "STHK_NtrY" ]

[ 5280 ]

1

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807", "PUB00042816", "PUB00042817" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844", "16926392", "12045829" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001, 2006, 2002 ]

15

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5184, 5, 91 ]

3

[]

0

true

Family

Nitrogen regulation protein NtrY

NtrY

9

IPR017233

17,233

WD repeat protein 35

WDR35

Family

1,641

false

WD repeat protein 35 (WDR35) is a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport [ ]. Mutations in the WDR35 gene cause diseases such as cranioectodermal dysplasia 2 [ ] and short-rib thoracic dysplasia 7 with or without polydactyly [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF037536" ]

[ "WD_repeat_p35" ]

[ 1641 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-RNO-5610787", "R-RNO-5620924" ]

[ "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924", "REACTOME:R-RNO-5610787", "REACTOME:R-RNO-5620924" ]

6

[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8fh3", "8hmc", "8hmd", "8ruy" ]

10

[ "PUB00083313", "PUB00083314", "PUB00083315" ]

[ "27806291", "20817137", "21473986" ]

[ "Role for the IFT-A Complex in Selective Transport to the Primary Cilium.", "Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome.", "Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis." ]

[ 2016, 2010, 2011 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1641 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 1, 3 ]

6

true

Family

WD repeat protein 35

WDR35

8

IPR017234

17,234

RNA-directed RNA polymerase, rhabdovirus

RNA-dir_pol_rhabdovirus

Family

1,667

false

RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw...

[ "GO:0016740", "GO:0006139" ]

[ "transferase activity", "nucleobase-containing compound metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037546" ]

[ "RNA_pol_RhabdoV_sub" ]

[ 1667 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.48", "2.7.7.88", "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289" ]

[ "EC:2.7.7.48", "EC:2.7.7.88", "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

13

[ "5a22", "6u1x", "6ueb" ]

3

[ "PUB00009392", "PUB00030617", "PUB00033622", "PUB00033623", "PUB00033624", "PUB00033625", "PUB00042722" ]

[ "9878607", "9309225", "2759231", "8709232", "11531403", "10827187", "17218273" ]

[ "Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.", "Structure of the RNA-dependent RNA polymerase of poliovirus.", "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat...

[ 1998, 1997, 1989, 1996, 2001, 2000, 2007 ]

7

[]

0

null

[ "Riboviria" ]

[ 1667 ]

1

[]

0

true

Family

RNA-directed RNA polymerase, rhabdovirus

RNA-dir_pol_rhabdovirus

8

IPR017235

17,235

RNA-directed RNA polymerase L, filovirus

RNA-dir_pol_L_filovirus

Family

752

false

RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw...

[ "GO:0016740", "GO:0006139" ]

[ "transferase activity", "nucleobase-containing compound metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF037548" ]

[ "RNA_pol_Filoviridae" ]

[ 752 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.48", "2.7.7.88", "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289" ]

[ "EC:2.7.7.48", "EC:2.7.7.88", "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

13

[ "7yer", "7yes", "7yet", "8jsl", "8jsm", "8jsn" ]

6

[ "PUB00009392", "PUB00030617", "PUB00033622", "PUB00033623", "PUB00033624", "PUB00033625", "PUB00042717" ]

[ "9878607", "9309225", "2759231", "8709232", "11531403", "10827187", "1546452" ]

[ "Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.", "Structure of the RNA-dependent RNA polymerase of poliovirus.", "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat...

[ 1998, 1997, 1989, 1996, 2001, 2000, 1992 ]

7

[]

0

null

[ "Filoviridae" ]

[ 752 ]

1

[]

0

true

Family

RNA-directed RNA polymerase L, filovirus

RNA-dir_pol_L_filovirus

9

IPR017236

17,236

Glycine/sarcosine/betaine reductase, component C, beta

Gly/sarc/bet/_Rdtase_C_bsu

Family

236

false

This group represents a glycine/sarcosine/betaine reductase complexes, C component, beta subunit.

[]

0

[ "PIRSF" ]

[ "PIRSF037559" ]

[ "Gly_sarc_betain_red_a" ]

[ 236 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 235, 1 ]

2

[]

0

true

Family

Glycine/sarcosine/betaine reductase, component C, beta

Gly/sarc/bet/_Rdtase_C_bsu

1

IPR017237

17,237

RLMG

Family

4,057

false

This entry represents rRNA (guanine-N(2)-)-methyltransferase G (RlmG; ). RlmG is a specific S-adenosylmethionine (AdoMet)-dependent methyltransferase responsible for N2-methylation of guanine at position 1835 (m2G1835) in 23S rRNA. The modified G1835 is located on the 50S subunit side of the intersubunit bridge B2, a f...

[ "GO:0008990", "GO:0031167", "GO:0005737" ]

[ "rRNA (guanine-N2-)-methyltransferase activity", "rRNA methylation", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_01859", "PIRSF037565" ]

[ "23SrRNA_methyltr_G", "RRNA_m2G_Mtase_RsmD_prd" ]

[ 3803, 4051 ]

2

[ "EC" ]

[ "2.1.1.174" ]

[ "EC:2.1.1.174" ]

1

[ "4dcm" ]

1

[ "PUB00101544", "PUB00101545" ]

[ "17010380", "22753782" ]

[ "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA.", "Structural insights into the function of 23S rRNA methyltransferase RlmG (m²G1835) from Escherichia coli." ]

[ 2006, 2012 ]

2

[ "IPR046977" ]

[]

1

0

1

[ "Bacteria", "Bracon brevicornis", "metagenomes" ]

[ 4042, 1, 14 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RLMG

9

IPR017238

17,238

Squamosa promoter-binding protein

SBP_fam

Family

407

false

This entry represents a group of DNA binding proteins, known as SBP (SQUAMOSA-pROMOTER BINDING PROTEIN) family. They are putative transcription factors characterised by a highly conserved SBP-box of 76 amino acids involved in DNA binding and nuclear localisation [ ]. They are involved in the control of early flower dev...

[ "GO:0003677", "GO:0003700", "GO:0009908" ]

[ "DNA binding", "DNA-binding transcription factor activity", "flower development" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF037575" ]

[ "SBP" ]

[ 407 ]

1

[]

0

[]

0

[ "PUB00007522", "PUB00074902", "PUB00074903", "PUB00074904" ]

[ "8569690", "20202170", "16914499", "24508602" ]

[ "A new family of DNA binding proteins includes putative transcriptional regulators of the Antirrhinum majus floral meristem identity gene SQUAMOSA.", "SQUAMOSA-PROMOTER BINDING PROTEIN 1 initiates flowering in Antirrhinum majus through the activation of meristem identity genes.", "Temporal regulation of shoot d...

[ 1996, 2010, 2006, 2014 ]

4

[ "IPR044817" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 407 ]

1

[ "Arabidopsis thaliana" ]

[ 6 ]

1

true

Family

Squamosa promoter-binding protein

SBP_fam

9

IPR017240

17,240

Mitogen-activated protein (MAP) kinase kinase kinase Ssk2/Ssk22

MAPKKK_Ssk2/Ssk22

Family

1,054

false

This entry includes a group of MAP kinase kinase kinase from fungi, including Ssk2/Ssk22 from budding yeasts and Win1/Wis4 from fission yeasts. They are kinases involved in a signal transduction pathway that is activated by environmental stress [ , , ].

[ "GO:0004709", "GO:0005524", "GO:0051403", "GO:0005737" ]

[ "MAP kinase kinase kinase activity", "ATP binding", "stress-activated MAPK cascade", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF037579" ]

[ "MAPKKK_SSK22" ]

[ 1054 ]

1

[ "EC" ]

[ "2.7.11.25" ]

[ "EC:2.7.11.25" ]

1

[]

0

[ "PUB00075294", "PUB00075295", "PUB00075296" ]

[ "9693384", "12853477", "9136929" ]

[ "The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.", "A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway.", "The Mcs4 response regulator coordina...

[ 1998, 2003, 1997 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1054 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2 ]

3

true

Family

Mitogen-activated protein (MAP) kinase kinase kinase Ssk2/Ssk22

MAPKKK_Ssk2/Ssk22

6

IPR017241

17,241

Toll-like receptor

Toll-like_receptor

Family

7,282

false

This entry represents toll-like receptors (TLRs), which are key regulators of immune responses. They recognise pathogen-associated molecular patterns (PAMPs) such as bacterial lipopeptides (TLR1/2/6), bacterial flagellin (TLR5), and lipopolysaccharide (TLR4) [ ]. In higher vertebrates, TLRs are essential not only for s...

[ "GO:0004888", "GO:0002224", "GO:0006955", "GO:0016020" ]

[ "transmembrane signaling receptor activity", "toll-like receptor signaling pathway", "immune response", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF037595" ]

[ "Toll-like_receptor" ]

[ 7282 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-168142", "R-GGA-433822", "R-GGA-451514", "R-GGA-517856", "R-HSA-1236974", "R-HSA-140534", "R-HSA-1461957", "R-HSA-166016", "R-HSA-166058", "R-HSA-166166", "R-HSA-168142", "R-HSA-168176", "R-HSA-168179", "R-HSA-168188", "R-HSA-2562578", "R-HSA-5602498", "R-HSA-5602680", "R-HS...

[ "REACTOME:R-BTA-168142", "REACTOME:R-GGA-433822", "REACTOME:R-GGA-451514", "REACTOME:R-GGA-517856", "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-140534", "REACTOME:R-HSA-1461957", "REACTOME:R-HSA-166016", "REACTOME:R-HSA-166058", "REACTOME:R-HSA-166166", "REACTOME:R-HSA-168142", "REACTOME:R-HSA-1...

56

[ "3j0a", "3w3g", "3w3j", "3w3k", "3w3l", "3w3m", "3w3n", "3wn4", "3wpb", "3wpc", "3wpd", "3wpe", "4qbz", "4qc0", "4r07", "4r08", "4r09", "4r0a", "4r6a", "5awa", "5awb", "5awc", "5awd", "5az5", "5gmf", "5gmg", "5gmh", "5hdh", "5wyx", "5wyz", "5y3j", "5y3k"...

76

[ "PUB00042888", "PUB00042889", "PUB00063166", "PUB00063167", "PUB00063168", "PUB00063170", "PUB00063193", "PUB00063194", "PUB00063195", "PUB00063196", "PUB00063199", "PUB00063200" ]

[ "18227810", "17457343", "16822173", "9039775", "16675322", "21741580", "2449285", "2124970", "8808632", "12872120", "11135568", "12888789" ]

[ "Toll-like receptors--taking an evolutionary approach.", "The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.", "Recognition and signaling by toll-like receptors.", "Innate immunity: impact on the adaptive immune response.", "Toll-like receptor function and signaling.", "T...

[ 2008, 2007, 2006, 1997, 2006, 2011, 1988, 1990, 1996, 2003, 2001, 2003 ]

12

[]

0

null

[ "Eukaryota" ]

[ 7282 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 31, 1, 62, 24, 25 ]

5

true

Family

Toll-like receptor

Toll-like_receptor

7

IPR017242

17,242

BLOC-1 complex, pallidin subunit

BLOC-1_pallidin

Family

964

false

Lysosomes are membrane-bound organelles found in animals that are involved in degradation of endogenous and exogenous macromolecules [ ]. Lysosome-related organelles occur in specific cell types and fulfil specialised functions e.g. melanosomes which synthesise and store pigments in higher eukaryotes. Lysosome biogenes...

[]

0

[ "PIRSF" ]

[ "PIRSF037609" ]

[ "BLOC-1_complex_pallidin" ]

[ 964 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-432722", "R-HSA-432722", "R-MMU-432722", "R-RNO-432722" ]

[ "REACTOME:R-BTA-432722", "REACTOME:R-HSA-432722", "REACTOME:R-MMU-432722", "REACTOME:R-RNO-432722" ]

4

[]

0

[ "PUB00043419", "PUB00043421", "PUB00067856" ]

[ "15261680", "10610180", "21998198" ]

[ "The building BLOC(k)s of lysosomes and related organelles.", "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency.", "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse." ]

[ 2004, 1999, 2011 ]

3

[ "IPR028119" ]

[]

1

0

1

[ "Metazoa" ]

[ 964 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4, 2, 2 ]

5

true

Family

BLOC-1 complex, pallidin subunit

BLOC-1_pallidin

6

IPR017243

17,243

Biogenesis of lysosome-related organelles complex 1 subunit 5

Bloc1s5

Family

1,502

false

Lysosomes are membrane-bound organelles found in animals that are involved in degradation of endogenous and exogenous macromolecules [ ]. Lysosome-related organelles occur in specific cell types and fulfil specialised functions e.g. melanosomes which synthesise and store pigments in higher eukaryotes. Lysosome biogenes...

[ "GO:0030133", "GO:0031083" ]

[ "transport vesicle", "BLOC-1 complex" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF14942", "PIRSF037610", "PTHR31784" ]

[ "Muted", "BLOC-1_complex_muted_subunit", "" ]

[ 1502, 590, 1325 ]

3

[]

0

[]

0

[ "PUB00043419", "PUB00043420", "PUB00067856" ]

[ "15261680", "11912185", "21998198" ]

[ "The building BLOC(k)s of lysosomes and related organelles.", "The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking.", "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to t...

[ 2004, 2002, 2011 ]

3

[]

0

null

[ "Eukaryota", "Marixanthomonas ophiurae" ]

[ 1501, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 5, 2, 2 ]

6

true

Family

Biogenesis of lysosome-related organelles complex 1 subunit 5

Bloc1s5

8