LiteFold/InterPro · Datasets at Hugging Face

IPR019615

19,615

Protein of unknown function DUF2487

DUF2487

Family

1,434

false

This entry represents proteins with unknown function that appears to be restricted to Bacillus sp.

[]

0

[ "PFAM" ]

[ "PF10673" ]

[ "DUF2487" ]

[ 1434 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli", "Physcomitrium patens" ]

[ 1433, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2487

DUF2487

2

IPR019617

19,617

Domain of unknown function DUF2489

DUF2489

Domain

1,647

false

This entry represents bacterial uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF10675" ]

[ "DUF2489" ]

[ 1647 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1638, 9 ]

2

[]

0

true

Domain

Domain of unknown function DUF2489

DUF2489

4

IPR019618

19,618

Spore germination protein GerPA/GerPF

Spore_germination_GerPA

Family

3,138

false

This is a bacterial family of proteins that are required for the formation of functionally normal spores. Proteins in this family may be involved in establishing normal coat structure and/or permeability which could control the access of germinants to their receptor [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10676", "PTHR37808" ]

[ "gerPA", "" ]

[ 3137, 2456 ]

2

[]

0

[]

0

[ "PUB00044278" ]

[ "10715007" ]

[ "Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 3136, 2 ]

2

[]

0

true

Family

Spore germination protein GerPA/GerPF

Spore_germination_GerPA

2

IPR019619

19,619

Protein of unknown function DUF2490

DUF2490

Family

4,918

false

This entry represents a bacterial family of uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF10677" ]

[ "DUF2490" ]

[ 4918 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctU4n16", "unclassified sequences" ]

[ 4870, 2, 1, 45 ]

4

[]

0

true

Family

Protein of unknown function DUF2490

DUF2490

1

IPR019620

19,620

Putative metal-binding protein

Metal-bd_prot_put

Family

1,457

false

This entry describes a family of small cytosolic proteins, about 80 amino acids in length, in which the eight invariant residues include three His residues and two Cys residues. Two pairs of these invariant residues occur in motifs HxH (where x is A or G) and CxH, both of which suggest metal-binding activity. This prot...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF10678", "TIGR03853" ]

[ "DUF2492", "matur_matur" ]

[ 1457, 1402 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Carpediemonas-like organisms", "metagenomes" ]

[ 1451, 2, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative metal-binding protein

Metal-bd_prot_put

2

IPR019621

19,621

Protein of unknown function DUF2491

DUF2491

Family

1,793

false

This entry represents a family of bacterial uncharacterised proteins, including YjfK ( ) from Escherichia coli.

[]

0

[ "PFAM" ]

[ "PF10679" ]

[ "DUF2491" ]

[ 1793 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1783, 2, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2491

DUF2491

3

IPR019622

19,622

Rrn9 domain

Rrn9_dom

Domain

1,041

false

This entry represent a domain found in the Rrn9 protein, a component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. This domain seems to be constrained to fungi, is the two highly conserved regions of p...

[]

0

[ "PFAM" ]

[ "PF10680" ]

[ "RRN9" ]

[ 1041 ]

1

[]

0

[ "7z0o" ]

1

[ "PUB00075586" ]

[ "9837969" ]

[ "Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1041 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Rrn9 domain

Rrn9_dom

7

IPR019623

19,623

Protein Rot1

Rot1

Family

1,315

false

Rot1 is a molecular chaperone involved in protein folding in ER [ ]. It is required for normal levels of the cell wall 1,6-beta-glucan [ ] and for protein N- and O-glycosylation [ ]. It also controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability [ ].

[ "GO:0006458", "GO:0005783" ]

[ "'de novo' protein folding", "endoplasmic reticulum" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF10681", "PIRSF017290", "PTHR28090" ]

[ "Rot1", "ROT1_prd", "" ]

[ 1315, 777, 1288 ]

3

[]

0

[]

0

[ "PUB00043303", "PUB00078784", "PUB00078785", "PUB00078786" ]

[ "15470097", "16567426", "22492205", "17606994" ]

[ "Rot1p of Saccharomyces cerevisiae is a putative membrane protein required for normal levels of the cell wall 1,6-beta-glucan.", "Saccharomyces cerevisiae Rot1p is an ER-localized membrane protein that may function with BiP/Kar2p in protein folding.", "The essential endoplasmic reticulum chaperone Rot1 is requi...

[ 2004, 2006, 2012, 2007 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 1312 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Protein Rot1

Rot1

7

IPR019624

19,624

Herpesvirus UL40

Herpes_UL40

Family

230

false

This entry represents glycoprotein UL40 from Human cytomegalovirus (HHV-5) (Human herpesvirus 5). HHV-5 has evolved mechanisms to interfere with a host's immune recognition, including targeting antigen presentation by MHC class I molecules. The signal sequence of the HHV-5 encoded UL40 polypeptide contains an HLA-E lig...

[]

0

[ "PFAM" ]

[ "PF10682" ]

[ "UL40" ]

[ 230 ]

1

[]

0

[]

0

[ "PUB00044525" ]

[ "10799855" ]

[ "Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis." ]

[ 2000 ]

1

[]

0

null

[ "Cytomegalovirus" ]

[ 230 ]

1

[]

0

true

Family

Herpesvirus UL40

Herpes_UL40

3

IPR019625

19,625

Biofilm-dependent modulation protein Bdm, putative

Biofilm-dep_modulation_Bdm_put

Family

458

false

This entry represents a group of tightly conserved proteins from Enterobacteriaceae which are annotated as being biofilm-dependent modulation protein homologues. This entry includes Bdm, whose expression is reduced in biofilms and is repressed by a high salt concentration [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008515", "PF10684" ]

[ "PRK11436.1", "BDM" ]

[ 448, 458 ]

2

[]

0

[]

0

[ "PUB00045436" ]

[ "10498711" ]

[ "Abiotic surface sensing and biofilm-dependent regulation of gene expression in Escherichia coli." ]

[ 1999 ]

1

[]

0

null

[ "Gammaproteobacteria", "Panagrolaimus superbus" ]

[ 457, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Biofilm-dependent modulation protein Bdm, putative

Biofilm-dep_modulation_Bdm_put

1

IPR019626

19,626

Stress-induced protein, KGG, repeat

Stress-induced_KGG_rpt

Repeat

6,555

false

This repeat contains a highly conserved, characteristic sequence motif, KGG, that is recognised by plants and lower eukaryotes. Further downstream from this motif is a Walker A, nucleotide binding motif. YciG is expressed as part of a three-gene operon, yciGFE and this operon is induced by stress and is regulated by Rp...

[]

0

[ "PFAM" ]

[ "PF10685" ]

[ "KGG" ]

[ 6555 ]

1

[]

0

[]

0

[ "PUB00045011" ]

[ "17293430" ]

[ "Physiological effects of Crl in Salmonella are modulated by sigmaS level and promoter specificity." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 5498, 14, 1023, 5, 15 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2, 1 ]

2

true

Repeat

Stress-induced protein, KGG, repeat

Stress-induced_KGG_rpt

2

IPR019627

19,627

YspA, cpYpsA-related SLOG

YAcAr

Domain

3,686

false

These proteins are related to the SLOG superfamily and show associations with NAD utilisation and ADP-ribosylation domains including NUDIX, NADAR and MACRO. They are predicted to function as sensors of nucleotides, nucleotide-derived ligands, or nucleic acids, which are potentially processed/modified by associating eff...

[]

0

[ "PFAM" ]

[ "PF10686" ]

[ "YAcAr" ]

[ 3686 ]

1

[]

0

[]

0

[ "PUB00091021" ]

[ "26590262" ]

[ "Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriati", "Opisthokonta", "Viruses", "metagenomes" ]

[ 3031, 27, 3, 530, 95 ]

5

[]

0

true

Domain

YspA, cpYpsA-related SLOG

YAcAr

4

IPR019629

19,629

Uncharacterised protein family HI1736/YgjV

Uncharacterised_HI1736/YgjV

Family

2,311

false

This entry represents inner membrane proteins, including the uncharacterised HI_1736 and YgjV proteins. Their function is unknown.

[]

0

[ "PFAM" ]

[ "PF10688" ]

[ "Imp-YgjV" ]

[ 2311 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR026267" ]

0

1

0

[ "Bacteria", "Methanobrevibacter", "unclassified sequences" ]

[ 2288, 9, 14 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family HI1736/YgjV

Uncharacterised_HI1736/YgjV

9

IPR019630

19,630

Protein of unknown function DUF2496, YbaM-related

DUF2496_YbaM-rel

Family

1,648

false

This family consists of proteins from Gammaproteobacteria species. Many members are annotated as being like the Escherichia coli protein; YbaM.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008266", "PF10689" ]

[ "PRK11038.1", "DUF2496" ]

[ 1457, 1648 ]

2

[]

0

[]

0

[ "PUB00104703" ]

[ "30872786" ]

[ "The rsmS (ybaM) mutation causes bypass suppression of the RsmAB post-transcriptional virulence regulation system in enterobacterial phytopathogens." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Callosobruchus maculatus", "marine sediment metagenome" ]

[ 1646, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2496, YbaM-related

DUF2496_YbaM-rel

3

IPR019631

19,631

Myticin preproprotein

Myticin_preproprotein

Family

228

false

Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis (Mediterranean mussel). Isoforms A and B show antibacterial activity against Gram-positive bacteria, while isoform B is additionally active against the fungus Fusarium oxysporum and a Gram-negative bacterium, Escheri...

[]

0

[ "PFAM" ]

[ "PF10690" ]

[ "Myticin-prepro" ]

[ 228 ]

1

[]

0

[ "2eem" ]

1

[ "PUB00044389" ]

[ "10491159" ]

[ "Myticin, a novel cysteine-rich antimicrobial peptide isolated from haemocytes and plasma of the mussel Mytilus galloprovincialis." ]

[ 1999 ]

1

[]

0

null

[ "Mytilinae" ]

[ 228 ]

1

[]

0

true

Family

Myticin preproprotein

Myticin_preproprotein

7

IPR019632

19,632

Protein of unknown function DUF2497

DUF2497

Family

2,282

false

Members of this family belong to the Alphaproteobacteria. The function of the family is not known.

[]

0

[ "PFAM" ]

[ "PF10691" ]

[ "DUF2497" ]

[ 2282 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 12, 2253, 17 ]

3

[]

0

true

Family

Protein of unknown function DUF2497

DUF2497

1

IPR019634

19,634

Uncharacterised protein family Ycf49

Uncharacterised_Ycf49

Family

1,325

false

This entry represents proteins found in plants, lower eukaryotes, and bacteria and the chloroplast where it is annotated as Ycf49 or Ycf49-like. The function is not known though several members are annotated as putative membrane proteins. As the family is primarily found in phototrophic organisms it may play a role in ...

[]

0

[ "PFAM" ]

[ "PF10693" ]

[ "DUF2499" ]

[ 1325 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 409, 916 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 4, 2 ]

3

true

Family

Uncharacterised protein family Ycf49

Uncharacterised_Ycf49

9

IPR019635

19,635

Protein of unknown function DUF2500

DUF2500

Family

2,813

false

This entry represents a group of proteins that is largely confined to the Gammaproteobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10694" ]

[ "DUF2500" ]

[ 2813 ]

1

[]

0

[ "2l0c", "3q6c", "3rd4" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2797, 3, 13 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2500

DUF2500

2

IPR019637

19,637

Protein of unknown function DUF2501

DUF2501

Family

1,706

false

This entry represents proteins that are found in Proteobacteria. Several are annotated as being YjjA or YjjA-like, but this protein is uncharacterised.

[]

0

[ "PFAM" ]

[ "PF10696" ]

[ "DUF2501" ]

[ 1706 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1703, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2501

DUF2501

4

IPR019638

19,638

Protein of unknown function DUF2502

DUF2502

Family

1,478

false

This entry represents proteins mainly found in Gammaproteobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10697" ]

[ "DUF2502" ]

[ 1478 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Beauveria bassiana D1-5", "Pseudomonadota" ]

[ 1, 1477 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF2502

DUF2502

4

IPR019639

19,639

Protein of unknown function DUF2505

DUF2505

Family

3,821

false

This entry represents proteins found Actinobacteria and Proteobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10698" ]

[ "DUF2505" ]

[ 3821 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3728, 48, 45 ]

3

[]

0

true

Family

Protein of unknown function DUF2505

DUF2505

2

IPR019642

19,642

Protein of unknown function DUF2507

DUF2507

Family

1,706

false

This entry represents a family of conserved proteins found primarily in Firmicutes. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10702" ]

[ "DUF2507" ]

[ 1706 ]

1

[]

0

[ "3njc" ]

1

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1705, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2507

DUF2507

7

IPR019644

19,644

Protein of unknown function DUF2508

DUF2508

Family

2,485

false

This entry represents a protein family of unknown function that is conserved in the firmicutes.

[]

0

[ "PFAM" ]

[ "PF10704" ]

[ "DUF2508" ]

[ 2485 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Oikopleura dioica", "ecological metagenomes" ]

[ 2470, 1, 14 ]

3

[]

0

true

Family

Protein of unknown function DUF2508

DUF2508

4

IPR019645

19,645

Uncharacterised protein family Ycf15

Uncharacterised_Ycf15

Family

2,844

false

In some species of plants the ycf15 gene is probably not a protein-coding gene because the protein in these species has premature stop codons. Most of the members of the family are hypothetical or uncharacterised [ ].

[]

0

[ "PFAM" ]

[ "PF10705" ]

[ "Ycf15" ]

[ 2844 ]

1

[]

0

[]

0

[ "PUB00044548" ]

[ "16303753" ]

[ "Complete nucleotide sequence of the chloroplast genome from the Tasmanian blue gum, Eucalyptus globulus (Myrtaceae)." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 9, 2835 ]

2

[ "Arabidopsis thaliana", "Zea mays" ]

[ 1, 2 ]

2

true

Family

Uncharacterised protein family Ycf15

Uncharacterised_Ycf15

5

IPR019647

19,647

PhoP regulatory network protein YrbL

PhoP_reg_network_YrbL

Family

1,532

false

This entry represents proteins that are activated by the protein PhoP. PhoP controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multi-compon...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007671", "PF10707" ]

[ "PRK10345.1", "YrbL-PhoP_reg" ]

[ 683, 1532 ]

2

[]

0

[]

0

[ "PUB00044556", "PUB00104599", "PUB00104600", "PUB00104601" ]

[ "15703297", "12813061", "15126461", "29379483" ]

[ "Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica.", "Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli.", "Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli.", "Virulence and Stress Resp...

[ 2005, 2003, 2004, 2017 ]

4

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Ecdysozoa", "metagenomes" ]

[ 1503, 1, 4, 24 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

PhoP regulatory network protein YrbL

PhoP_reg_network_YrbL

1

IPR019648

19,648

Protein YebY

YebY

Family

1,564

false

This protein family, formerly known as DUF2511, includes Protein YebY from Escherichia coli and similar proteins predominantly found in Gammaproteobacteria. YebY is a component of the AZY copper uptake system, where it functions as a negative regulator of the copper importer YebZ [ ]. At high copper concentrations, Yeb...

[]

0

[ "PFAM" ]

[ "PF10709" ]

[ "DUF2511" ]

[ 1564 ]

1

[]

0

[ "2mvo", "6qfp", "7n0j" ]

3

[ "PUB00100157", "PUB00100158", "PUB00163268" ]

[ "34822841", "25923468", "40108346" ]

[ "The copper-linked E. coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery.", "Distinct mechanisms contribute to immunity in the lantibiotic NAI-107 producer strain Microbispora ATCC PTA-5024.", "The Escherichia coli AZY operon links copper uptake to antibiotic resista...

[ 2021, 2016, 2025 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1552, 8, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein YebY

YebY

7

IPR019649

19,649

Protein of unknown function DUF2512

DUF2512

Family

1,756

false

Proteins in this entry are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.

[]

0

[ "PFAM" ]

[ "PF10710" ]

[ "DUF2512" ]

[ 1756 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "ecological metagenomes" ]

[ 1750, 1, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF2512

DUF2512

7

IPR019650

19,650

Protein of unknown function DUF2513

DUF2513

Family

1,149

false

The function of this family is not known.

[]

0

[ "PFAM" ]

[ "PF10711" ]

[ "DUF2513" ]

[ 1149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobiaceae", "Viruses", "metagenomes" ]

[ 1095, 2, 46, 6 ]

4

[]

0

true

Family

Protein of unknown function DUF2513

DUF2513

4

IPR019651

19,651

Glutamate dehydrogenase, NAD-specific

Glutamate_DH_NAD-spec

Family

733

false

The best-characterised protein in this entry is an NAD-specific glutamate dehydrogenase encoded in an antisense gene pair arrangement with a DnaK-J-like protein [ ].

[]

0

[ "PFAM" ]

[ "PF10712" ]

[ "NAD-GH" ]

[ 733 ]

1

[]

0

[]

0

[ "PUB00045338" ]

[ "8308022" ]

[ "Molecular characterization of an NAD-specific glutamate dehydrogenase gene inducible by L-glutamine. Antisense gene pair arrangement with L-glutamine-inducible heat shock 70-like protein gene." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 117, 556, 20, 40 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 7, 2 ]

3

true

Family

Glutamate dehydrogenase, NAD-specific

Glutamate_DH_NAD-spec

7

IPR019652

19,652

Protein of unknown function DUF2509

DUF2509

Family

1,422

false

This entry represents a conserved protein found in Proteobacteria. The function is not known but many of the members are annotated as protein YgdB.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008569", "PF10713" ]

[ "PRK11521.1", "DUF2509" ]

[ 825, 1422 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1422 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2509

DUF2509

7

IPR019654

19,654

NAD(P)H-quinone oxidoreductase subunit L

NADH-quinone_OxRdatse_su_L

Family

899

false

NAD(P)H-quinone oxidoreductase subunit L (NdhL) is a component of the NDH-1L complex that is one of the proton-pumping NADH:ubiquinone oxidoreductases that catalyse the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. NDH-1L is essential for photoheterotrophic cell growth....

[ "GO:0016655" ]

[ "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_01355", "PF10716" ]

[ "NDH1_NDH1L", "NdhL" ]

[ 347, 899 ]

2

[ "EC" ]

[ "7.1.1.-" ]

[ "EC:7.1.1.-" ]

1

[ "6hum", "6khi", "6khj", "6l7o", "6l7p", "6nbq", "6nbx", "6nby", "6tjv", "7eu3", "7f9o", "7wfg", "7wg5", "9grx" ]

14

[ "PUB00044393" ]

[ "15548534" ]

[ "Identification of NdhL and Ssl1690 (NdhO) in NDH-1L and NDH-1M complexes of Synechocystis sp. PCC 6803." ]

[ 2005 ]

1

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 354, 545 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 2, 6 ]

3

true

Family

NAD(P)H-quinone oxidoreductase subunit L

NADH-quinone_OxRdatse_su_L

4

IPR019655

19,655

Baculovirus occlusion-derived virus envelope, E18

Baculo_ODV-E18

Family

119

false

Baculovirus occlusion-derived virus (ODV) derives its envelope from an intranuclear membrane source. Occlusion-derived viral envelope proteins that are detected in viral-induced intranuclear microvesicles, but not detected in the plasma membrane, cytoplasmic membranes, or the nuclear envelope. This entry represents ODV...

[ "GO:0019031" ]

[ "viral envelope" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF10717" ]

[ "ODV-E18" ]

[ 119 ]

1

[]

0

[]

0

[ "PUB00019199" ]

[ "8091653" ]

[ "Transcription, translation, and cellular localization of PDV-E66: a structural protein of the PDV envelope of Autographa californica nuclear polyhedrosis virus." ]

[ 1994 ]

1

[]

0

null

[ "Baculoviridae", "Takifugu flavidus" ]

[ 118, 1 ]

2

[]

0

true

Family

Baculovirus occlusion-derived virus envelope, E18

Baculo_ODV-E18

8

IPR019656

19,656

Uncharacterised protein family Ycf34

Uncharacterised_Ycf34

Family

659

false

This entry represents Ycf34, a protein encoded in algal genomes and additionally found in cyanobacteria. The function is not known. As the family is exclusively found in phototrophic organisms it may play a role in photosynthesis.

[]

0

[ "PFAM" ]

[ "PF10718" ]

[ "Ycf34" ]

[ 659 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 364, 295 ]

2

[]

0

true

Family

Uncharacterised protein family Ycf34

Uncharacterised_Ycf34

6

IPR019657

19,657

Late competence development protein ComFB

ComFB

Family

2,596

false

Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...

[]

0

[ "PFAM" ]

[ "PF10719" ]

[ "ComFB" ]

[ 2596 ]

1

[]

0

[ "4wai", "8hja" ]

2

[ "PUB00033881", "PUB00052316", "PUB00052317" ]

[ "8412657", "8901420", "10361283" ]

[ "comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.", "Who's competent and when: regulation of natural genetic competence in bacteria.", "Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence develop...

[ 1993, 1996, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2564, 2, 30 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Late competence development protein ComFB

ComFB

9

IPR019658

19,658

Protein of unknown function DUF2515

DUF2515

Family

2,129

false

This family is conserved in Firmicutes. Several members are annotated as YppC. The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF10720" ]

[ "DUF2515" ]

[ 2129 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ricinus communis", "ecological metagenomes" ]

[ 2123, 1, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF2515

DUF2515

5

IPR019659

19,659

Protein of unknown function DUF2514

DUF2514

Family

1,957

false

This protein family is conserved in bacteria and some viruses. The function is not known. This entry includes the protein gp55 from Enterobacteria phage N15.

[]

0

[ "PFAM" ]

[ "PF10721" ]

[ "DUF2514" ]

[ 1957 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1821, 4, 121, 11 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2514

DUF2514

3

IPR019660

19,660

Putative sensory transduction regulator YbjN

Put_sensory_transdc_reg_YbjN

Family

12,806

false

YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for ...

[]

0

[ "PFAM" ]

[ "PF10722" ]

[ "YbjN" ]

[ 12806 ]

1

[]

0

[ "2plg", "4h5b", "5fr7", "5frk", "6vu7" ]

5

[ "PUB00044547" ]

[ "16701556" ]

[ "Analysis of the temperature-sensitive mutation of Escherichia coli pantothenate kinase reveals YbjN as a possible protein stabilizer." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4, 12567, 26, 209 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative sensory transduction regulator YbjN

Put_sensory_transdc_reg_YbjN

3

IPR019661

19,661

Replication regulatory protein RepA2

RepA2

Family

2,617

false

This family of proteins regulates the replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of the replication of the RCR plasmids occurs mainly at the initiation of leading strand synthesis at the dso, such that concentration of Rep protein controls pla...

[ "GO:0006276" ]

[ "plasmid maintenance" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10723" ]

[ "RepB-RCR_reg" ]

[ 2617 ]

1

[]

0

[]

0

[ "PUB00044457" ]

[ "9409148" ]

[ "Rolling-circle replication of bacterial plasmids." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Haloferax volcanii", "Viruses", "plasmids", "unclassified sequences" ]

[ 2584, 13, 1, 6, 2, 11 ]

6

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Replication regulatory protein RepA2

RepA2

9

IPR019662

19,662

Protein of unknown function DUF2516

DUF2516

Family

3,560

false

This entry represents a conserved protein in Actinobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10724" ]

[ "DUF2516" ]

[ 3560 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3532, 28 ]

2

[]

0

true

Family

Protein of unknown function DUF2516

DUF2516

2

IPR019663

19,663

Uncharacterised protein YbfA

YbfA

Family

1,197

false

This entry represents proteins conserved in Proteobacteria and includes the predicted protein YbfA. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10725" ]

[ "DUF2517" ]

[ 1197 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1196, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein YbfA

YbfA

3

IPR019664

19,664

Ycf51

Family

376

false

This entry contains the Ycf51 protein family, which is conserved in Cyanobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10726" ]

[ "DUF2518" ]

[ 376 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 365, 11 ]

2

[]

0

true

Family

Ycf51

6

IPR019665

19,665

Putative oxidoreductase/dehydrogenase, Rossmann-like domain

OxRdtase/DH_put_Rossmann_dom

Domain

6,118

false

This entry represents an NAD/NADP-binding domain with a core Rossmann-type fold, found in an uncharacterised protein family thought to be putative NADP oxidoreductase coenzyme F420-dependent proteins and/or NAD-dependent glycerol-3-phosphate dehydrogenase-like proteins. This Rossmann-fold domain consists of 3-layers α/...

[]

0

[ "PFAM" ]

[ "PF10727" ]

[ "Rossmann-like" ]

[ 6118 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5998, 5, 115 ]

3

[]

0

true

Domain

Putative oxidoreductase/dehydrogenase, Rossmann-like domain

OxRdtase/DH_put_Rossmann_dom

7

IPR019666

19,666

Cell division activator CedA

Cell_div_activator_CedA

Family

719

false

CedA is involved in the regulation of cell division in Escherichia coli and related organisms. It is structurally similar to dsDNA-binding domains and has been found to interact with dsDNA. The protein comprises four antiparallel β-strands, an α-helix, and a large unstructured N terminus. As dsDNA binding domains, it m...

[ "GO:0003677", "GO:0051301" ]

[ "DNA binding", "cell division" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01580", "NF007510", "PF10729" ]

[ "CedA", "PRK10113.1", "CedA" ]

[ 428, 715, 719 ]

3

[]

0

[ "2bn8", "2d35", "8ftd" ]

3

[ "PUB00039688", "PUB00044186" ]

[ "15865419", "9427399" ]

[ "Solution structure and interactions of the Escherichia coli cell division activator protein CedA.", "CedA is a novel Escherichia coli protein that activates the cell division inhibited by chromosomal DNA over-replication." ]

[ 2005, 1997 ]

2

[]

0

null

[ "Gammaproteobacteria", "bioreactor metagenome" ]

[ 718, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cell division activator CedA

Cell_div_activator_CedA

4

IPR019667

19,667

Uncharacterised protein family YbaK

Uncharacterised_YbaK

Family

616

false

This entry represents a protein of unknown function specific to Bacillus.

[]

0

[ "PFAM" ]

[ "PF10730" ]

[ "DUF2521" ]

[ 616 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Trichinella papuae" ]

[ 615, 1 ]

2

[]

0

true

Family

Uncharacterised protein family YbaK

Uncharacterised_YbaK

6

IPR019668

19,668

Uncharacterised protein family YtzC

Uncharacterised_YtzC

Family

608

false

This entry represents proteins with unknown function, and appear to be restricted to the Bacillaceae.

[]

0

[ "PFAM" ]

[ "PF10732" ]

[ "DUF2524" ]

[ 608 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Candidatus Nitrososphaera evergladensis SR1", "Rotaria" ]

[ 596, 1, 11 ]

3

[]

0

true

Family

Uncharacterised protein family YtzC

Uncharacterised_YtzC

5

IPR019669

19,669

Uncharacterised bacterial stress protein YodD

Uncharacterised_YodD

Family

698

false

This entry represents the uncharacterised protein family YodD which appear to be restricted to Enterobacteriaceae, and are thought to be stress-related proteins [ ].

[]

0

[ "PFAM" ]

[ "PF10733" ]

[ "DUF2525" ]

[ 698 ]

1

[]

0

[]

0

[ "PUB00054160" ]

[ "19919618" ]

[ "Identification of stress-related proteins in Escherichia coli using the pollutant cis-dichloroethylene." ]

[ 2010 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Gammaproteobacteria" ]

[ 1, 697 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised bacterial stress protein YodD

Uncharacterised_YodD

3

IPR019670

19,670

Protein of unkown function DUF2523

DUF2523

Family

1,235

false

This entry represents a family of phage-related proteins whose function is uncharacterised.

[]

0

[ "PFAM" ]

[ "PF10734" ]

[ "DUF2523" ]

[ 1235 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1154, 3, 67, 11 ]

4

[]

0

true

Family

Protein of unkown function DUF2523

DUF2523

5

IPR019671

19,671

Protein of unknown function DUF2526

DUF2526

Family

786

false

This entry represents proteins with unknown function and is a highly conserved sequence, it is restricted to Enterobacteriaceae.

[]

0

[ "PFAM" ]

[ "PF10735" ]

[ "DUF2526" ]

[ 786 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 781, 3, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2526

DUF2526

1

IPR019672

19,672

Protein of unknown function DUF2627

DUF2527

Family

593

false

This entry represents small proteins with unknown function and appear to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence. Some proteins are annotated as YobF and may be involved in stress responses in E. coli.

[]

0

[ "PFAM" ]

[ "PF10736" ]

[ "DUF2527" ]

[ 593 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 593 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2627

DUF2527

1

IPR019673

19,673

Spore germination protein GerPC

Spore_germination_GerPC

Family

1,055

false

GerPC is required for the formation of functionally normal spores. The gerP locus encodes a number of proteins which are thought to be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [ ].

[]

0

[ "PFAM" ]

[ "PF10737" ]

[ "GerPC" ]

[ 1055 ]

1

[]

0

[]

0

[ "PUB00044278" ]

[ "10715007" ]

[ "Mutations in the gerP locus of Bacillus subtilis and Bacillus cereus affect access of germinants to their targets in spores." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Halobellus clavatus", "Plasmodium fragile" ]

[ 1053, 1, 1 ]

3

[]

0

true

Family

Spore germination protein GerPC

Spore_germination_GerPC

9

IPR019674

19,674

Lipoprotein LpqN/LpqT-like

Lipoprotein_LpqN/LpqT-like

Family

1,549

false

This protein is conserved in Mycobacteriaceae and is likely to be a lipoprotein [ ]. lpqN is involved in cell envelope lipid changes during biofilm maturation. It interacts with periplasmic loop domains of the MmpL3 and MmpL11 transporters that export mycolic acid-containing cell envelope lipids. It also interacts with...

[]

0

[ "PFAM" ]

[ "PF10738" ]

[ "Lpp-LpqN" ]

[ 1549 ]

1

[]

0

[ "3lyd", "4ol4", "4pws", "6e5d", "6e5f", "6mna" ]

6

[ "PUB00044336", "PUB00095088", "PUB00095089" ]

[ "15539077", "31471317", "30118676" ]

[ "Lipoproteins of Mycobacterium tuberculosis: an abundant and functionally diverse class of cell envelope components.", "Structural and functional evidence that lipoprotein LpqN supports cell envelope biogenesis in Mycobacterium tuberculosis.", "Bacterial Protein Reshapes Host Defense toward Antiviral Responses....

[ 2004, 2019, 2018 ]

3

[]

0

null

[ "Bacteria", "Candidatus Nitrosotenuis uzonensis", "freshwater metagenome" ]

[ 1546, 1, 2 ]

3

[]

0

true

Family

Lipoprotein LpqN/LpqT-like

Lipoprotein_LpqN/LpqT-like

2

IPR019676

19,676

Domain of unknown function DUF2529

DUF2529

Domain

994

false

This domain is conserved in the Bacillales. The function is not known, but given this domains relationship to the SIS domain it may carry out a sugar isomerase reaction. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.

[]

0

[ "PFAM" ]

[ "PF10740" ]

[ "DUF2529" ]

[ 994 ]

1

[]

0

[ "3jx9" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 994 ]

1

[]

0

true

Domain

Domain of unknown function DUF2529

DUF2529

4

IPR019678

19,678

Protein of unknown function DUF2555

DUF2555

Family

361

false

This entry represents Uncharacterized protein ssl0461, a conserved proteins found in Cyanobacteria. The function is not known.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF050006", "PF10742" ]

[ "ssl0461_fam", "DUF2555" ]

[ 352, 361 ]

2

[]

0

[]

0

[ "PUB00162596", "PUB00162597" ]

[ "34019114", "32332138" ]

[ "New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation.", "Transcriptome Analysis Reveals IsiA-Regulatory Mechanisms Underlying Iron Depletion and Oxidative-Stress Acclimation in <i>Synechocystis</i> sp. Strain PCC 6803." ]

[ 2021, 2020 ]

2

[]

0

null

[ "Bacteria" ]

[ 361 ]

1

[]

0

true

Family

Protein of unknown function DUF2555

DUF2555

9

IPR019679

19,679

Regulatory phage protein Cox

Phage_P2_Cox

Family

832

false

Cox proteins are expressed by Enterobacteria phages. The Cox protein is a 79-residue basic protein with a predicted strong helix-turn-helix DNA-binding motif. It inhibits integrative recombination and it activates site-specific excision of the HP1 genome from the Haemophilus influenzae chromosome, Hp1. Cox appears to f...

[]

0

[ "PFAM" ]

[ "PF10743" ]

[ "Phage_Cox" ]

[ 832 ]

1

[]

0

[ "4lhf" ]

1

[ "PUB00044432" ]

[ "9079698" ]

[ "Purification and characterization of HP1 Cox and definition of its role in controlling the direction of site-specific recombination." ]

[ 1997 ]

1

[]

0

null

[ "Caudoviricetes", "Ecdysozoa", "Gammaproteobacteria" ]

[ 81, 3, 748 ]

3

[]

0

true

Family

Regulatory phage protein Cox

Phage_P2_Cox

3

IPR019680

19,680

Mediator complex, subunit Med1

Mediator_Med1

Domain

3,715

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF10744" ]

[ "Med1" ]

[ 3715 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-383280", "R-DME-400206", "R-DME-9018519", "R-DME-9707564", "R-DME-9841922", "R-HSA-1368108", "R-HSA-1989781", "R-HSA-212436", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-381340", "R-HSA-383280", "R-HSA-400206", "R-HSA-9018519", "R-HSA-9707564", "R-HSA-9707616", "R-HSA-9833110", ...

[ "REACTOME:R-DME-383280", "REACTOME:R-DME-400206", "REACTOME:R-DME-9018519", "REACTOME:R-DME-9707564", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-2426168", "REACTOME:R-HSA-381340", "REACTOME:R-...

24

[ "6xp5", "7emf", "7ena", "7enc", "7enj", "7ui9", "7uif", "7uig", "7uil", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

19

[ "PUB00044352" ]

[ "12150923" ]

[ "Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3715 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 5, 3, 2, 1, 5, 1, 1 ]

8

true

Domain

Mediator complex, subunit Med1

Mediator_Med1

9

IPR019681

19,681

Protein of unknown function DUF2530

DUF2530

Family

2,981

false

This entry represents proteins with unknown function found in mycobacteria and in other Actinobacteria.

[]

0

[ "PFAM" ]

[ "PF10745" ]

[ "DUF2530" ]

[ 2981 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "metagenomes" ]

[ 2894, 87 ]

2

[]

0

true

Family

Protein of unknown function DUF2530

DUF2530

6

IPR019682

19,682

Bacteriophage T7, Gp17.5, holin

Phage_T7_Gp17.5_holin

Family

620

false

This entry represents a protein conserved in Caudovirales (known as tailed bacteriophages). Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis by forming micro-pores through which endolysins and virus particles can escape from the cell. Holins accumulate in the cyt...

[ "GO:0044659" ]

[ "viral release from host cell by cytolysis" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04108", "PF10746" ]

[ "HOLIN_T7", "Phage_holin_2_2" ]

[ 415, 620 ]

2

[]

0

[]

0

[ "PUB00014565" ]

[ "11018145" ]

[ "Holins: the protein clocks of bacteriophage infections." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Viruses" ]

[ 63, 557 ]

2

[]

0

true

Family

Bacteriophage T7, Gp17.5, holin

Phage_T7_Gp17.5_holin

5

IPR019683

19,683

Sporulation inhibitor of replication protein SirA

SirA

Family

832

false

This entry represents the Sporulation inhibitor of replication (sirA) family of proteins from Bacillus sp. Induction of sporulation in rapidly growing cells inhibits replication; this is thought to be through the action of SirA protein and independent of phosphorylated Spo0A; however SirA protein synthesis is induced b...

[]

0

[ "PFAM" ]

[ "PF10747" ]

[ "SirA" ]

[ 832 ]

1

[]

0

[ "4tps" ]

1

[ "PUB00054159" ]

[ "19329632" ]

[ "The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis." ]

[ 2009 ]

1

[]

0

null

[ "Bacillota" ]

[ 832 ]

1

[]

0

true

Family

Sporulation inhibitor of replication protein SirA

SirA

9

IPR019684

19,684

HofP protein

HofP

Family

1,074

false

The Escherischia coli protein HofP is a member of this family and is one of eight genes shown to be required for the utilization of extracellular DNA as a nutrient source in starving conditions, allowing DNA to be the sole source for carbon and energy [ ]. Proteins in this entry are found only in Enterobacteriaceae.

[]

0

[ "PFAM" ]

[ "PF10748" ]

[ "HofP" ]

[ 1074 ]

1

[]

0

[]

0

[ "PUB00068649" ]

[ "16707682" ]

[ "Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrient." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 1073, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HofP protein

HofP

9

IPR019685

19,685

Protein of unknown function DUF2534

DUF2534

Family

824

false

This entry represents proteins with unknown function, and appear to be restricted to Enterobacteriaceae.

[]

0

[ "PFAM" ]

[ "PF10749" ]

[ "DUF2534" ]

[ 824 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammaproteobacteria", "Opisthokonta", "bioreactor metagenome" ]

[ 821, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2534

DUF2534

1

IPR019686

19,686

Protein of unknown function DUF2536

DUF2536

Family

601

false

This entry represents proteins with unknown function appears to be restricted to Bacillus spp.

[]

0

[ "PFAM" ]

[ "PF10750" ]

[ "DUF2536" ]

[ 601 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 601 ]

1

[]

0

true

Family

Protein of unknown function DUF2536

DUF2536

6

IPR019687

19,687

Protein of unknown function DUF2535

DUF2535

Family

419

false

This entry represents proteins with unknown function, and appear to be restricted to Bacillus spp.

[]

0

[ "PFAM" ]

[ "PF10751" ]

[ "DUF2535" ]

[ 419 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales", "Limulus polyphemus" ]

[ 417, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF2535

DUF2535

2

IPR019688

19,688

Protein of unknown function DUF2533

DUF2533

Family

545

false

This entry represents proteins with unknown function, and appear to be restricted to Bacillus spp.

[]

0

[ "PFAM" ]

[ "PF10752" ]

[ "DUF2533" ]

[ 545 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Dreissena polymorpha" ]

[ 544, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2533

DUF2533

7

IPR019689

19,689

Toxin GhoT/OrtT

Toxin_GhoT/OrtT

Family

1,130

false

GhoT is part of the GhoT-GhoS type V toxin-antitoxin (TA) system. GhoT is inhibited by antitoxin GhoS, which specifically cleaves its mRNA [ , ]. OrtT is homologous to GhoT, but it is not part of a TA pair. In this case, it acts as an independent toxin to reduce growth during stress related to amino acid and DNA synthe...

[]

0

[ "PFAM" ]

[ "PF10753" ]

[ "Toxin_GhoT_OrtT" ]

[ 1130 ]

1

[]

0

[]

0

[ "PUB00065335", "PUB00074307", "PUB00074308" ]

[ "22941047", "25643179", "23289863" ]

[ "A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS.", "Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response.", "Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS." ]

[ 2012, 2015, 2013 ]

3

[]

0

null

[ "Bacteria", "Timema californicum", "Viruses" ]

[ 1122, 1, 7 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Toxin GhoT/OrtT

Toxin_GhoT/OrtT

3

IPR019690

19,690

Protein of unknown function DUF2569

DUF2569

Family

2,245

false

This entry represents a protein that is conserved in bacteria. The function is not known, but several members are annotated as being YdgK or a homologue thereof and associated to the inner membrane. This signature also matches proteins that are described as transglutaminase-like enzymes, although this could not be conf...

[]

0

[ "PFAM" ]

[ "PF10754" ]

[ "DUF2569" ]

[ 2245 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Dikarya", "metagenomes" ]

[ 2232, 2, 11 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2569

DUF2569

9

IPR019691

19,691

Protein of unknown function DUF2585

DUF2585

Family

1,272

false

This family is conserved in Proteobacteria. The function is not known, but it is thought to be a transmembrane protein.

[ "GO:0005886" ]

[ "plasma membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01514", "NF002099", "PF10755" ]

[ "UPF0314", "PRK00944.1", "DUF2585" ]

[ 857, 1063, 1272 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Megaviricetes", "ecological metagenomes" ]

[ 1248, 15, 2, 7 ]

4

[]

0

true

Family

Protein of unknown function DUF2585

DUF2585

5

IPR019692

19,692

Low molecular weight protein antigen 6, PH domain

CFP-6_PH

Domain

8,785

false

This entry represents a domain found in prokaryotic proteins, mainly from Actinomycetales, including Low molecular weight protein antigen 6 from Mycobacterium tuberculosis (CFP-6, [ ]). The domain, previously known as DUF2581, has a bacterial type PH domain structure.

[]

0

[ "PFAM" ]

[ "PF10756" ]

[ "bPH_6" ]

[ 8785 ]

1

[]

0

[]

0

[ "PUB00052311" ]

[ "10812229" ]

[ "Isolation, purification and immunological characterization of novel low molecular weight protein antigen CFP 6 from culture filtrate of M. tuberculosis." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "Monascus purpureus", "metagenomes" ]

[ 8745, 21, 1, 18 ]

4

[]

0

true

Domain

Low molecular weight protein antigen 6, PH domain

CFP-6_PH

9

IPR019693

19,693

Biofilm formation regulator YbaJ

Biofilm_formation_reg_YbaJ

Family

1,124

false

YbaJ regulates biofilm formation. It also has an important role in the regulation of motility in the biofilm. YbaJ functions in increasing conjugation, aggregation and decreasing the motility, resulting in an increase of biofilm [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007948", "PF10757" ]

[ "PRK10667.1", "YbaJ" ]

[ 1071, 1124 ]

2

[]

0

[ "2mn2" ]

1

[ "PUB00044546" ]

[ "16317765" ]

[ "Hha, YbaJ, and OmpA regulate Escherichia coli K12 biofilm formation and conjugation plasmids abolish motility." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1123, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Biofilm formation regulator YbaJ

Biofilm_formation_reg_YbaJ

8

IPR019694

19,694

Bacteriophage HP1, Orf23

Phage_HP1_Orf23

Family

1,686

false

This entry is represented by Bacteriophage HP1, Orf23. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family of proteins is a component of a contractile injection system related to phage sheath proteins [ ].

[]

0

[ "PFAM" ]

[ "PF10758" ]

[ "DUF2586" ]

[ 1686 ]

1

[]

0

[]

0

[ "PUB00097484" ]

[ "30905475" ]

[ "Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Lophotrochozoa", "Viruses", "metagenomes" ]

[ 1584, 4, 80, 18 ]

4

[]

0

true

Family

Bacteriophage HP1, Orf23

Phage_HP1_Orf23

1

IPR019695

19,695

Bacterial proteasome activator

Proteasome_act

Family

3,216

false

This is a family of bacterial proteasome cofactors. The family member from Mycobacterium tuberculosis, protein Rv3780, was shown to form rings and cap proteasome core particles. It enhanced peptide and protein degradation by proteasomes in an adenosine triphosphate (ATP)-independent manner, promoting degradation of the...

[ "GO:0061136" ]

[ "regulation of proteasomal protein catabolic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10759" ]

[ "BPA" ]

[ 3216 ]

1

[]

0

[ "5iet", "5ieu", "5lfj", "5lfp", "5lfq", "5lzp", "6bgl", "6bgo", "8rgx" ]

9

[ "PUB00076684" ]

[ "25831519" ]

[ "An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis." ]

[ 2015 ]

1

[]

0

null

[ "Actinomycetota", "Mesorhabditis spiculigera", "metagenomes" ]

[ 3155, 1, 60 ]

3

[]

0

true

Family

Bacterial proteasome activator

Proteasome_act

7

IPR019698

19,698

Protein of unknown function DUF2583

DUF2583

Family

1,089

false

Some members in this entry are annotated as YchH however currently no function is known.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007968", "PF10762" ]

[ "PRK10692.1", "DUF2583" ]

[ 1030, 1089 ]

2

[]

0

[]

0

[ "PUB00054160", "PUB00104644" ]

[ "19919618", "17608696" ]

[ "Identification of stress-related proteins in Escherichia coli using the pollutant cis-dichloroethylene.", "New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome." ]

[ 2010, 2007 ]

2

[]

0

null

[ "Bacteria", "Timema californicum", "bioreactor metagenome" ]

[ 1087, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2583

DUF2583

3

IPR019699

19,699

Protein of unknown function DUF2584

DUF2584

Family

676

false

This entry represents a group of proteins mainly found in Bacilli, including Uncharacterized protein YtmB from Bacillus subtilis. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF10763" ]

[ "DUF2584" ]

[ 676 ]

1

[]

0

[ "2nwa" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 676 ]

1

[]

0

true

Family

Protein of unknown function DUF2584

DUF2584

2

IPR019700

19,700

Anti-sigma-G factor Gin

Sigma-G_inhibitor_Gin

Family

1,531

false

Gin allows sigma-F to delay late forespore transcription by preventing sigma-G to take over before the cell has reached a critical stage of development. Gin is also known as CsfB [ ].

[]

0

[ "PFAM" ]

[ "PF10764" ]

[ "Gin" ]

[ 1531 ]

1

[]

0

[ "5n7y" ]

1

[ "PUB00044279" ]

[ "18208527" ]

[ "How the early sporulation sigma factor sigmaF delays the switch to late development in Bacillus subtilis." ]

[ 2008 ]

1

[]

0

null

[ "Bacillota", "bioreactor metagenome" ]

[ 1528, 3 ]

2

[]

0

true

Family

Anti-sigma-G factor Gin

Sigma-G_inhibitor_Gin

2

IPR019703

19,703

Inner membrane protein YbjO, dehydrogenase-like

YbjO_DH-like

Family

1,052

false

This entry includes the Inner membrane protein YbjO which appears to be restricted to Enterobacteriaceae. From AlphaFold structure predictions, it has been suggested that these proteins may function as dehydrogenases, accounting in its structural similarity with the C-terminal region of Acyl-CoA dehydrogenases.

[]

0

[ "PFAM" ]

[ "PF10767" ]

[ "YbjO_DH-like" ]

[ 1052 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Trichuris trichiura", "human gut metagenome" ]

[ 1050, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YbjO, dehydrogenase-like

YbjO_DH-like

4

IPR019704

19,704

Flagellar assembly regulator FliX, class II

Flagellar_assmbl_FliX_class2

Family

802

false

The FliX protein is possibly a transient component of the flagellum that is required for the assembly process. FliX may contribute to the targeting or assembly of the P- and L-ring protein monomers at the cell pole. The family carries a potential N-terminal signal sequence and at least one transmembrane domain indicati...

[ "GO:0044781" ]

[ "bacterial-type flagellum organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10768" ]

[ "FliX" ]

[ 802 ]

1

[]

0

[]

0

[ "PUB00044265" ]

[ "9555902" ]

[ "A membrane-associated protein, FliX, is required for an early step in Caulobacter flagellar assembly." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Symbiodinium", "metagenomes" ]

[ 789, 2, 11 ]

3

[]

0

true

Family

Flagellar assembly regulator FliX, class II

Flagellar_assmbl_FliX_class2

2

IPR019707

19,707

MJ1608-like

MJ1608

Family

1,212

false

This entry represents Uncharacterized protein MJ1608 and related uncharacterised proteins found in prokaryotes. The structure of two proteins ( and ) in this family were solved using NMR and shown to adopt a winged helix-turn-helix fold [ ]. Structural analysis shows that these proteins form an unusual dimeric conforma...

[]

0

[ "PFAM" ]

[ "PF10771" ]

[ "DUF2582" ]

[ 1212 ]

1

[]

0

[ "2l01", "2l02" ]

2

[ "PUB00075673" ]

[ "22223187" ]

[ "Solution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 56, 1111, 45 ]

3

[]

0

true

Family

MJ1608-like

MJ1608

2

IPR019708

19,708

Bacteriophage HP1, Orf24

Phage_HP1_Orf24

Family

788

false

This entry represents proteins with unknown function found in tailed bacteriophages and Proteobacteria, including Putative tail tube protein from Haemophilus phage HP1 (Orf24). The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF10772" ]

[ "Phage_HP1_Orf24" ]

[ 788 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Capitella teleta", "Caudoviricetes", "metagenomes" ]

[ 758, 1, 26, 3 ]

4

[]

0

true

Family

Bacteriophage HP1, Orf24

Phage_HP1_Orf24

2

IPR019710

19,710

Protein of unknown function DUF4226

DUF4226

Family

767

false

This entry represents an uncharacterised family of proteins belonging to Mycobacteria. It was previously incorrectly annotated as biofilm regulator BssS (also known as YliH).

[]

0

[ "PFAM" ]

[ "PF10774" ]

[ "DUF4226" ]

[ 767 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycobacteriales" ]

[ 767 ]

1

[]

0

true

Family

Protein of unknown function DUF4226

DUF4226

9

IPR019711

19,711

ATP synthase, F0 complex, subunit H

ATP_synth_F0_suH

Family

1,669

false

This entry represents subunit H found in the F0 complex of F-ATPases from fungal mitochondria. Subunit H is homologous to the mammalian factor F6 [ ], and is essential for the correct assembly and/or functioning of F-ATPases, since yeast cells lacking it are not able to grow on non-fermentable carbon sources [ , ]. Sub...

[ "GO:0015986" ]

[ "proton motive force-driven ATP synthesis" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10775", "PTHR28207" ]

[ "ATP_sub_h", "" ]

[ 1669, 1591 ]

2

[]

0

[ "6cp3", "6cp6", "7tjy", "7tjz", "7tk0", "7tk1", "7tk2", "7tk3", "7tk4", "7tk5", "7tk6", "7tk7", "7tk8", "7tk9", "7tka", "7tkb", "7tkc", "7tkd", "7tke", "7tkf", "7tkg", "7tkh", "7tki", "7tkj", "7tkk", "7tkl", "7tkm", "7tkn", "7tko", "7tkp", "7tkq", "7tkr"...

37

[ "PUB00009752", "PUB00020603", "PUB00020604", "PUB00044161", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00081960", "PUB00081961" ]

[ "11309608", "15473999", "15078220", "14556635", "20450191", "18937357", "1385979", "9741106", "18252710", "11083870" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Topological and functional ...

[ 2001, 2004, 2004, 2003, 2010, 2008, 1992, 1998, 2008, 2001 ]

10

[]

0

null

[ "Eukaryota" ]

[ 1669 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

ATP synthase, F0 complex, subunit H

ATP_synth_F0_suH

5

IPR019712

19,712

Tetraprenyl-beta-curcumene synthase YtpB-like

YtpB-like

Family

1,471

false

In Bacillus subtilis, YtpB catalyses the transformation of a linear C35 prenyl diphosphate chain to form tetraprenyl-beta-curcumene [ ]. This entry also contains trifunctional sesterterpene/triterpene/sesquarterpene synthase which catalyses the conversion of geranylfarnesyl diphosphate (GFPP) into beta-geranylfarnesene...

[]

0

[ "PFAM" ]

[ "PF10776" ]

[ "DUF2600" ]

[ 1471 ]

1

[]

0

[ "5yo8", "6loo", "6lop" ]

3

[ "PUB00092485", "PUB00094232", "PUB00094233" ]

[ "21627333", "25882275", "23554321" ]

[ "Sesquarterpenes (C35 terpenes) biosynthesized via the cyclization of a linear C35 isoprenoid by a tetraprenyl-β-curcumene synthase and a tetraprenyl-β-curcumene cyclase: identification of a new terpene cyclase.", "Biosynthesis of Sesterterpenes, Head-to-Tail Triterpenes, and Sesquarterpenes in Bacillus clausii: ...

[ 2011, 2015, 2013 ]

3

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1462, 1, 8 ]

3

[]

0

true

Family

Tetraprenyl-beta-curcumene synthase YtpB-like

YtpB-like

1

IPR019713

19,713

Inner membrane protein YlaC

Memb_YlaC

Family

1,175

false

Members of this family include proteins annotated as inner membrane protein YlaC in E. coli and Salmonella. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF10777" ]

[ "YlaC" ]

[ 1175 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1171, 3, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YlaC

Memb_YlaC

3

IPR019714

19,714

2-haloacid dehalogenase, DehI

2-haloacid_dehalogenase_DehI

Family

155

false

Haloacid dehalogenases catalyse the removal of halides from organic haloacids. The 2-haloacid dehalogenase DehI can process both L- and D-substrates. A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuratio...

[ "GO:0019120" ]

[ "hydrolase activity, acting on halide bonds, in C-halide compounds" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10778" ]

[ "DehI" ]

[ 155 ]

1

[]

0

[ "3bjx", "5gzx", "5gzy", "5h00", "5h01" ]

5

[ "PUB00044223" ]

[ "18353360" ]

[ "The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "marine metagenome" ]

[ 102, 52, 1 ]

3

[]

0

true

Family

2-haloacid dehalogenase, DehI

2-haloacid_dehalogenase_DehI

3

IPR019715

19,715

Haemolysin XhlA

Haemolysin_XhlA

Family

1,372

false

Haemolysin XhlA from Bacillus subtilis is a cell-surface associated haemolysin that lyses the two most prevalent types of insect immune cells (granulocytes and plasmatocytes) as well as rabbit and horse erythrocytes [ ]. This entry also includes Holin-like protein 24.1 from Bacillus phage SPP1. Protein 24.1 may act lik...

[]

0

[ "PFAM" ]

[ "PF10779" ]

[ "XhlA" ]

[ 1372 ]

1

[]

0

[]

0

[ "PUB00044543", "PUB00084988" ]

[ "15659065", "27328857" ]

[ "Expression and activity of a Xenorhabdus nematophila haemolysin required for full virulence towards Manduca sexta insects.", "More than a hole: the holin lethal function may be required to fully sensitize bacteria to the lytic action of canonical endolysins." ]

[ 2005, 2016 ]

2

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 1278, 90, 4 ]

3

[]

0

true

Family

Haemolysin XhlA

Haemolysin_XhlA

9

IPR019716

19,716

Large ribosomal subunit protein mL53

Ribosomal_mL53

Family

3,040

false

This entry represents the large ribosomal subunit protein mL53, previously known as L53 (also known as L44), which is part of the 39S ribosome [ ]. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This l...

[]

0

[ "PFAM" ]

[ "PF10780" ]

[ "MRP_L53" ]

[ 3040 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "3j7y", "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g"...

96

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00044382" ]

[ "11297922", "11290319", "11114498", "17604309" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Reconstructing the evolution of the mitochondrial ribosomal proteome." ]

[ 2001, 2001, 2000, 2007 ]

4

[]

[ "IPR042776" ]

0

1

0

[ "Eukaryota" ]

[ 3040 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain ...

[ 3, 1, 2, 1, 1, 1, 1, 1, 1 ]

9

true

Family

Large ribosomal subunit protein mL53

Ribosomal_mL53

8

IPR019717

19,717

Dextransucrase DSRB

Dextransucrase_DSRB

Family

1,115

false

DSRB is a novel dextransucrase which produces a dextran different from the typical dextran, as it contains (1-6) and (1-2) linkages, when this strain is grown in the presence of sucrose [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01549", "NF007981", "PF10781" ]

[ "DsrB", "PRK10708.1", "DSRB" ]

[ 977, 1099, 1115 ]

3

[]

0

[]

0

[ "PUB00044230", "PUB00104651" ]

[ "9503626", "8670904" ]

[ "Cloning and sequencing of a gene coding for an extracellular dextransucrase (DSRB) from Leuconostoc mesenteroides NRRL B-1299 synthesizing only a alpha (1-6) glucan.", "The small RNA, DsrA, is essential for the low temperature expression of RpoS during exponential growth in Escherichia coli." ]

[ 1998, 1996 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 1113, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Dextransucrase DSRB

Dextransucrase_DSRB

2

IPR019718

19,718

Protein of unknown function DUF2602

DUF2602

Family

897

false

This entry represents a family of proteins predominantly found in Firmicutes, including Uncharacterized protein YpeQ from Bacillus subtilis. Members of this group adopt the structure of a zinc-finger domain of the C2HC type with an additional cysteine. They have no known function.

[]

0

[ "PFAM" ]

[ "PF10782" ]

[ "zf-C2HCIx2C" ]

[ 897 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Strongyloides stercoralis", "human gut metagenome" ]

[ 895, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF2602

DUF2602

3

IPR019719

19,719

Protein of unknown function DUF2599

DUF2599

Family

1,202

false

The function of the bacterial proteins in this entry is not known.

[]

0

[ "PFAM" ]

[ "PF10783" ]

[ "DUF2599" ]

[ 1202 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Brachionus", "bioreactor metagenome" ]

[ 1199, 2, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF2599

DUF2599

5

IPR019720

19,720

Plasmid stability protein, StbB

Plasmid_stability_protein_StbB

Family

1,061

false

This family is conserved in the Enterobacteriales. It is a putative plasmid stability protein in that it is expressed from the operon involved in stability, but its actual function has not yet been characterised but it may be involved in the control of plasmid partition.

[]

0

[ "PFAM" ]

[ "PF10784" ]

[ "Plasmid_stab_B" ]

[ 1061 ]

1

[]

0

[ "2jd3" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 1058, 3 ]

2

[]

0

true

Family

Plasmid stability protein, StbB

Plasmid_stability_protein_StbB

9

IPR019721

19,721

NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal

NADH-UbQ_OxRdtase_su21_N

Domain

2,443

false

This domain is found in the N-terminal region of NADH-ubiquinone oxidoreductase 21kDa subunits from plants and fungi [ ].

[]

0

[ "PFAM" ]

[ "PF10785" ]

[ "NADH-u_ox-rdase" ]

[ 2443 ]

1

[]

0

[ "6gcs", "6rfq", "6rfr", "6rfs", "6x89", "6y79", "6yj4", "7a23", "7a24", "7aqq", "7ar7", "7ar8", "7ar9", "7arb", "7ard", "7b0n", "7o6y", "7o71", "7tgh", "7zkp", "7zm7", "7zm8", "7zmb", "7zme", "7zmg", "7zmh", "8b6f", "8bef", "8bpx", "8bq5", "8bq6", "8bqs"...

42

[ "PUB00055569" ]

[ "1445273" ]

[ "Primary structure and mitochondrial import in vitro of the 20.9 kDa subunit of complex I from Neurospora crassa." ]

[ 1992 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2443 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 1, 6, 4 ]

4

true

Domain

NADH-ubiquinone oxidoreductase, 21kDa subunit, N-terminal

NADH-UbQ_OxRdtase_su21_N

7

IPR019723

19,723

Uncharacterised protein, YfmQ

Uncharacterised_YfmQ

Family

643

false

This family of proteins is uncharacterised.

[]

0

[ "PFAM" ]

[ "PF10787" ]

[ "YfmQ" ]

[ 643 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 643 ]

1

[]

0

true

Family

Uncharacterised protein, YfmQ

Uncharacterised_YfmQ

3

IPR019724

19,724

Uncharacterised protein family UPF0763

UPF0763

Family

285

false

This entry represents a conserved protein in epsilonproteobacteria. The function is not known.

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_02110", "PF10788" ]

[ "UPF0763", "DUF2603" ]

[ 250, 285 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Epsilonproteobacteria" ]

[ 285 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0763

UPF0763

9

IPR019725

19,725

Bacteriophage T4, P15K, RNA polymerase binding

Phage_T4_P15K_Rpol-bd

Family

308

false

Upon infection, the RpbA encoded phage protein binds to the ADP-ribosylated core RNA polymerase and modulates function to preferentially bind T4 promoters. This is a non-essential protein to the phage life cycle.

[]

0

[ "PFAM" ]

[ "PF10789" ]

[ "Phage_RpbA" ]

[ 308 ]

1

[]

0

[ "8k58", "8k59", "8k5a" ]

3

[]

0

[]

0

null

[ "Flagellimonas marina", "Viruses" ]

[ 1, 307 ]

2

[]

0

true

Family

Bacteriophage T4, P15K, RNA polymerase binding

Phage_T4_P15K_Rpol-bd

3

IPR019726

19,726

Protein of unknown function DUF2604

DUF2604

Family

76

false

This entry represents Uncharacterized protein y4jI and related bacterial proteins with undetermined function.

[]

0

[ "PFAM" ]

[ "PF10790" ]

[ "DUF2604" ]

[ 76 ]

1

[]

0

[ "8tyx", "8tyy", "8tyz", "8tz0", "8u38", "9d5b" ]

6

[]

0

[]

0

null

[ "Bacteria", "Cirrhinus molitorella", "metagenomes" ]

[ 70, 1, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF2604

DUF2604

9

IPR019727

19,727

ATP synthase, F0 complex, subunit F, mitochondria, fungi

ATP_synth_F0_fsu_mt_fun

Family

1,693

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0015986" ]

[ "proton motive force-driven ATP synthesis" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10791", "PTHR28161" ]

[ "F1F0-ATPsyn_F", "" ]

[ 1692, 1641 ]

2

[]

0

[ "6b2z", "6b8h", "6cp3", "6cp5", "6cp6", "6cp7", "6wtd", "7tjy", "7tjz", "7tk0", "7tk1", "7tk2", "7tk3", "7tk4", "7tk5", "7tk6", "7tk7", "7tk8", "7tk9", "7tka", "7tkb", "7tkc", "7tkd", "7tke", "7tkf", "7tkg", "7tkh", "7tki", "7tkj", "7tkk", "7tkl", "7tkm"...

42

[ "PUB00009752", "PUB00020603", "PUB00020604", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00081962", "PUB00081963" ]

[ "11309608", "15473999", "15078220", "20450191", "18937357", "1385979", "9741106", "9288937", "10449235" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Regulation and isoform func...

[ 2001, 2004, 2004, 2010, 2008, 1992, 1998, 1997, 1999 ]

9

[]

0

null

[ "Eukaryota" ]

[ 1693 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

ATP synthase, F0 complex, subunit F, mitochondria, fungi

ATP_synth_F0_fsu_mt_fun

9

IPR019728

19,728

Protein of unknown function DUF2605

DUF2605

Family

310

false

This entry represents Uncharacterized protein slr0270, a protein conserved in Cyanobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10792" ]

[ "DUF2605" ]

[ 310 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 310 ]

1

[]

0

true

Family

Protein of unknown function DUF2605

DUF2605

7

IPR019729

19,729

Gloverin-like protein

Gloverin-like_protein

Family

158

false

This entry represents proteins that are Gloverin-like. Gloverin is a 13.8kDa inducible antibacterial insect protein which inhibits the synthesis of vital outer membrane proteins leading to a permeable outer membrane. Gloverin contains a large number of glycine residues [ ].

[]

0

[ "PFAM" ]

[ "PF10793" ]

[ "Gloverin" ]

[ 158 ]

1

[]

0

[]

0

[ "PUB00044280" ]

[ "18076111" ]

[ "Functional analysis of four Gloverin-like genes in the silkworm, Bombyx mori." ]

[ 2008 ]

1

[]

0

null

[ "Ditrysia" ]

[ 158 ]

1

[]

0

true

Family

Gloverin-like protein

Gloverin-like_protein

8

IPR019730

19,730

Protein of unknown function DUF2606

DUF2606

Family

107

false

This entry represents bacterial proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF10794" ]

[ "DUF2606" ]

[ 107 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 107 ]

1

[]

0

true

Family

Protein of unknown function DUF2606

DUF2606

5

IPR019731

19,731

Protein of unknown function DUF2607

DUF2607

Family

178

false

This entry represents conserved protein found in in Gammaproteobacteria. The function is not known.

[]

0

[ "PFAM" ]

[ "PF10795" ]

[ "DUF2607" ]

[ 178 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine metagenome" ]

[ 177, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2607

DUF2607

7

IPR019732

19,732

Sigma-S stabilisation anti-adaptor protein

SigmaS_Anti-adapt_IraP

Family

1,084

false

This entry is conserved in Enterobacteriaceae. It is one of a series of proteins, expressed by these bacteria in response to stress, that help to regulate Sigma-S, the stationary phase sigma factor of Escherichia coli and Salmonella. IraP is essential for Sigma-S stabilisation in some but not all starvation conditions ...

[ "GO:0005737" ]

[ "cytoplasm" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01198", "NF007598", "PF10796" ]

[ "Anti_adapt_IraP", "PRK10244.1", "Anti-adapt_IraP" ]

[ 589, 950, 1084 ]

3

[]

0

[ "8gkv" ]

1

[ "PUB00044149" ]

[ "18383615" ]

[ "Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors." ]

[ 2008 ]

1

[]

0

null

[ "Erwinia phage vB_EhrS_49", "Eumetazoa", "Pseudomonadati", "human gut metagenome" ]

[ 1, 2, 1080, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sigma-S stabilisation anti-adaptor protein

SigmaS_Anti-adapt_IraP

5

IPR019733

19,733

Uncharacterised protein family YhfT

Uncharacterised_YhfT

Family

872

false

This entry represents a group of proteins from Firmicutes, Proteobacteria and Actinobacteria, including Uncharacterized protein YhfT from Escherichia coli, which is predicted to be a membrane protein. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF10797" ]

[ "YhfT" ]

[ 872 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 864, 2, 6 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family YhfT

Uncharacterised_YhfT

2